In utero exposure to tiny air pollution particles is linked to asthma in preschoolers
Mount Sinai researchers are first to find ultrafine particles from traffic pollution influences asthma risk in US children
New York, NY (May 21, 2021) --Women who were highly exposed to ultra-fine particles in air pollution during their pregnancy were more likely to have children who developed asthma, according to a study published in the American Journal of Respiratory and Critical Care Medicine in May. This is the first time asthma has been linked with prenatal exposure to this type of air pollution, which is named for its tiny size and which is not regulated or routinely monitored in the United States.
Slightly more than 18 percent of the children born to these mothers developed asthma in their preschool years, compared to 7 percent of children overall in the United States identified as having asthma by the Centers for Disease Control and Prevention.
Other types of pollutants are routinely monitored and regulated to reduce potential health effects, such as larger-size particulate pollution and gaseous pollutants such as nitrogen dioxide. These have been associated with asthma risk in children in prior research. This study controlled for exposure to these other types of pollution and exposure to pollutants following birth, and it still found an elevated risk of asthma in children born to mothers with heightened exposure to ultra-fine particles in pregnancy.
Ultra-fine particulate pollution--particles that are smaller than the width of an average human hair--can get deeper into our lungs and pass into our circulation to cause various health effects. Because of this, the researchers said their toxic effects may actually be greater.
"One reason ultra-fine particulates are not routinely monitored is that there have been a number of unique challenges to measuring them accurately. Fortunately, recent methods have been developed to provide such exposure data which allowed us to conduct this study," said lead author Rosalind Wright, MD, MPH, Horace W. Goldsmith Professor in Children's Health Research, Professor of Environmental Medicine and Public Health and Co-director of the Institute for Exposomic Research at the Icahn School of Medicine at Mount Sinai.
This study included 376 mothers and their children, most of them Black or Latinx, who live in the Boston metropolitan area and were already being followed to assess their health. Mount Sinai researchers partnered with a group of scientists at Tufts University in the Boston area who had developed a way to provide valid daily estimations of ultra-fine particulate exposure which could be linked to the area of the mothers' and children's homes. Many of these women were more likely to live near major roadways with higher traffic density where exposure to these tiny particles tends to be higher.
The researchers followed up with the mothers to find out whether the children were diagnosed with asthma. Most of the diagnoses of asthma occurred just after three years of age.
Pollution's effect in utero can alter lung development and respiratory health. This can lead to pediatric disorders like asthma. How this happens is not completely understood but pollution can alter certain bodily regulatory systems like neuroendocrine and immune function that have been linked with asthma in other studies.
While both boys and girls were affected by prenatal ultrafine particle exposure, this study found that girl babies were more sensitive to ultra-fine particle pollution's effects on asthma risk when exposed in late pregnancy. The reason for this phenomenon is also unclear, but studies show it is possibly due to endocrine-disrupting effects of the pollution exposure.
"This research is an important early step in building the evidence base that can lead to better monitoring of exposure to ultrafine particles in the United States and ultimately to regulation. As we advance methods for measuring these tiny particles, we hope for replication of these findings, both within different geographic areas across the United States as well as globally. Childhood asthma remains a global epidemic that is likely to grow with the anticipated rise in particulate air pollution exposures due to effects of climate change," Dr. Wright said.
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This research was funded by grants from the National Institutes of Health including the Environmental Influences on Child Health Outcomes (ECHO) Program.
About The Institute for Exposomic Research
The Institute for Exposomic Research at the Icahn School of Medicine at Mount Sinai is the world's first research institute devoted to the intensive study of the exposome, or the totality of environmental influences on human health. The mission of the Institute is to understand how the complex mix of nutritional, chemical, and social environments affect health, disease, and development later in life and to translate those findings into new strategies for prevention and treatment. For more information, visit http://icahn.
About the Mount Sinai Health System
The Mount Sinai Health System is New York City's largest academic medical system, encompassing eight hospitals, a leading medical school, and a vast network of ambulatory practices throughout the greater New York region. Mount Sinai is a national and international source of unrivaled education, translational research and discovery, and collaborative clinical leadership ensuring that we deliver the highest quality care--from prevention to treatment of the most serious and complex human diseases. The Health System includes more than 7,200 physicians and features a robust and continually expanding network of multispecialty services, including more than 400 ambulatory practice locations throughout the five boroughs of New York City, Westchester, and Long Island. The Mount Sinai Hospital is ranked No. 14 on U.S. News & World Report's "Honor Roll" of the Top 20 Best Hospitals in the country and the Icahn School of Medicine as one of the Top 20 Best Medical Schools in country. Mount Sinai Health System hospitals are consistently ranked regionally by specialty and our physicians in the top 1% of all physicians nationally by U.S. News & World Report.
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