Association of long-term exposure to particulate air pollution with cardiovascular events
JAMA Network Open
Peer-Reviewed PublicationAbout The Study: In this study including 3.7 million adults in California, long-term fine particulate air pollution (PM2.5) exposure at moderate concentrations was associated with increased risks of heart attack, ischemic heart disease mortality and cardiovascular disease mortality. The findings add to the evidence that the current regulatory standard is not sufficiently protective.
Authors: Stacey E. Alexeeff, Ph.D., of the Kaiser Permanente Division of Research in Oakland, California, is the corresponding author.
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
JOURNAL
JAMA Network Open
Current air pollution standards tied to higher heart risks
Kaiser Permanente study of 3.7 million adults provides support for strengthening air quality standards.
Peer-Reviewed PublicationOAKLAND, Calif. — Long-term exposure to air pollution is tied to an increased risk of having a heart attack or dying from heart disease — with the greatest harms impacting under-resourced communities, new Kaiser Permanente research shows.
The study, published February 24 in JAMA Network Open, is one of the largest to date to look at the effects of long-term exposure to fine particle air pollution, which is emitted from sources such as vehicles, smokestacks, and fires. Fine particle air pollution, also known as PM2.5, are fine particles that are 2.5 micrometers in diameter or smaller. The research lends support to current efforts to make the country’s air pollution standards more stringent.
“We found that people exposed to fine particulate air pollution have an increased risk of experiencing a heart attack or dying from coronary heart disease — even when those exposure levels are at or below our current U.S. air quality standards,” said lead author Stacey E. Alexeeff, PhD, a research scientist and biostatistician at the Kaiser Permanente Division of Research. “Our work has the potential to play an important role in ongoing national conversations led by the Environmental Protection Agency on whether — and how much — to tighten air quality standards to protect the public from pollution’s effects.”
The study included 3.7 million adults who were members of Kaiser Permanente in Northern California from 2007 to 2016 and had lived in California for at least one year. The researchers tied each adult’s address to a specific geographical location — a process known as geocoding — to establish annual average exposure to fine particle pollution so it could be linked to annual PM2.5 exposure data. Then they identified the patients diagnosed with a heart attack or who had died from heart disease or cardiovascular disease.
The Environmental Protection Agency’s current annual regulatory standard for fine particle air pollution PM2.5 is 12 micrograms per cubic meter, on average, over a year. Long-term exposure to fine particle air pollution PM2.5, is a known risk factor for cardiovascular disease. That’s why the EPA initially instituted air quality standards.
The study found that PM2.5 exposure at a concentration between 12.0 and 13.9 micrograms per cubic meter was associated with a 10% increased risk of experiencing a heart attack and a 16% increased risk of dying from heart disease or cardiovascular disease compared to concentrations less than 8 micrograms per cubic meter. Heart disease is a condition that develops when cholesterol builds up inside the heart’s arteries, preventing the heart from getting the blood and oxygen it needs. Cardiovascular disease is a broad category covering all the diseases that can affect the heart and blood vessels, such as heart failure, stroke, and peripheral artery disease.
In January 2023, the EPA announced a proposal to tighten the annual PM2.5 standard by reducing the acceptable level to between 9.0 to 10.0 micrograms per cubic meter. The EPA said it was advising this change because the current standard did not adequately protect public health under the guidelines required by the Clean Air Act.
The study also looked at diagnoses of heart attacks and deaths from heart disease and cardiovascular disease in people whose exposures were below the current standard of 12 micrograms per cubic meter. The study showed a 6% increased risk of heart attack and a 7% increased risk of death from heart disease in adults exposed to air pollution at moderate concentrations of 10.0 to 11.9 micrograms per cubic meter compared to low concentrations of less than 8.0 micrograms per cubic meter. This suggests people would see health benefits if the new standard were 10.0 micrograms per cubic meter or less.
Additional analyses found that the increased risk of heart attacks persisted even at concentrations of 8.0 to 9.9 micrograms per cubic meter compared to concentrations below 8.0 micrograms per cubic meter. This suggests the U.S. would see fewer heart attacks if the new standard were reduced to 8.0 micrograms per cubic meter.
“This is one of the largest studies to date to look at the impact of air pollution on heart disease,” said senior author Stephen Sidney, MD, MPH, a research scientist at the Division of Research. “Importantly, Kaiser Permanente’s electronic health records made it possible for us to account for other factors that might increase a person’s risk of having a heart attack or developing cardiovascular disease, such as smoking status, body mass index, or having other illnesses, such as diabetes. This allows us to be confident in our conclusion that fine particle air pollution has adverse associations with cardiovascular health.”
The study also showed that neighborhood socioeconomic status was tied to pollution exposure and the risk of cardiovascular disease. “We found strong evidence that neighborhood matters when it comes to exposures to this type of air pollution,” said co-author Stephen Van Den Eeden, PhD, a research scientist at the Division of Research. “The strongest association between exposure to air pollution and risk of cardiovascular events in our study was seen in people who live in low socioeconomic areas, where there is often more industry, busier streets, and more highways.”
The researchers say their findings add important new information to ongoing policy discussions. “Our study clearly adds to the evidence that the current regulatory standards are not sufficient to protect the public,” said Dr. Alexeeff. “Our findings support the EPA’s analysis that lowering the standard to at least 10.0 micrograms per cubic meter is needed to protect the public. Our findings also suggest that lowering the standard to 8.0 micrograms per cubic meter may be needed to reduce the risk of heart attacks.”
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About Kaiser Permanente
Kaiser Permanente is committed to helping shape the future of health care. We are recognized as one of America’s leading health care providers and not-for-profit health plans. Founded in 1945, Kaiser Permanente has a mission to provide high-quality, affordable health care services and to improve the health of our members and the communities we serve. We currently serve 12.6 million members in 8 states and the District of Columbia. Care for members and patients is focused on their total health and guided by their personal Permanente Medical Group physicians, specialists, and team of caregivers. Our expert and caring medical teams are empowered and supported by industry-leading technology advances and tools for health promotion, disease prevention, state-of-the-art care delivery, and world-class chronic disease management. Kaiser Permanente is dedicated to care innovations, clinical research, health education, and the support of community health. For more information, go to about.kp.org
JOURNAL
JAMA Network Open
ARTICLE TITLE
Particulate air pollution and cardiovascular events: a retrospective cohort study of 3.7 million adults using electronic health records
ARTICLE PUBLICATION DATE
24-Feb-2023
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