Tuesday, October 17, 2023

 

Thermosensation is critical for the survival of animals, but the mechanisms by which this is modulated by nutritional status remain unclear


Behavioral and live brain imaging studies reveal why food-sated fruit flies prefer to stay at relatively higher temperatures compared to hungry flies

Peer-Reviewed Publication

PLOS

Thermosensation is critical for the survival of animals, but the mechanisms by which this is modulated by nutritional status remain unclear 

IMAGE: 

DIFFERENT INTERNAL FEEDING STATES ALTER Α´Β´ MUSHROOM BODY’S (GREEN, UPPER PANEL) NEURONAL ACTIVITIES IN THE BRAIN OF FRUIT FLY, WHICH CONTRIBUTE TO MODERATE AND STRONG HOT AVOIDANCE BEHAVIORS DURING SATIETY AND HUNGER, RESPECTIVELY. THE BOTTOM PANEL SHOWING THE NEUROPIL OF A WHOLE FLY BRAIN (MAGENTA, BRAIN WAS STAINED WITH ANTI-DISCS LARGE ANTIBODY) WHERE THE Α´Β´ MUSHROOM BODY NEURONS ARE GENETICALLY LABELED WITH GREEN FLUORESCENT PROTEIN (GREEN).

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CREDIT: MENG-HSUAN CHIANG & CHIA-LIN WU, CHIANG M-H ET AL., 2023, PLOS BIOLOGY, CC-BY 4.0 (HTTPS://CREATIVECOMMONS.ORG/LICENSES/BY/4.0/)




Thermosensation is critical for the survival of animals, but the mechanisms by which this is modulated by nutritional status remain unclear; here, behavioral and live brain imaging studies reveal why food-sated fruit flies prefer to stay at relatively higher temperatures compared to hungry flies.

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In your coverage, please use this URL to provide access to the freely available paper in PLOS Biologyhttp://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002332

Article Title: Independent insulin signaling modulators govern hot avoidance under different feeding states

Author Countries: Taiwan

Funding: This work was supported by grants from the National Science and Technology Council (112-2311-B-182-002-MY3 and 109-2326-B-182-001-MY3) to C-LW, Chang Gung Memorial Hospital (CMRPD1M0301-3, CMRPD1M0761-3, and BMRPC75) to C-LW. The funders had no role in the study design, data collection and analysis, decision to publish, or manuscript preparation.

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