Decline of mpox antibody responses after modified vaccinia Ankara–Bavarian Nordic vaccination

JAMA Network

About The Study: 

The modified vaccinia Ankara–Bavarian Nordic (MVA-BN) vaccination generated mpox antibodies that waned by 6 to 12 months. In participants who received 2 doses of MVA-BN vaccine, mpox antibody responses at 12 months were comparable to or lower than peak antibody responses in people receiving 1 dose, which provided limited protection.

Quote from corresponding author Dan H. Barouch, MD, PhD:

“In this observational study, we show that mpox antibody responses decline 6-12 months following Jynneos (MVA-BN) vaccination. Our data suggest that protective immunity may be waning in individuals who were vaccinated with this vaccine in 2022.”

Contact information for Dan H. Barouch, MD, PhD: email dbarouch@bidmc.harvard.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jama.2024.20951)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Journal

JAMA