Monday, November 11, 2024

The monkeys that science has experimented on for over a century

Daniel Bellamy
Sun, November 10, 2024 
EURONEWS 


The rhesus macaque monkeys that managed to escape lab this week are among the most studied animals on the planet.

So far just one of the 43 that were bred for medical research - and that escaped from the lab - has been recovered unharmed, officials said on Saturday.

Many of the others are still located a few yards from away, jumping back and forth over the facility’s fence, police said in a statement.

An employee at the Alpha Genesis facility in Yemassee hadn't fully locked a door as she fed and checked on them, officials said.

For more than a century, they have held a mirror to humanity, revealing our strengths and weaknesses through their own clever behaviours, organ systems and genetic code.

The bare-faced primates with expressive eyes have been launched on rockets into space. Their genome has been mapped. They have even been stars of a reality TV show.

Animal rights groups point out that the species has been subjected to studies on vaccines, organ transplants and the impact of separating infants from mothers. At the same time, many in the scientific community will tell you just how vital their research is to fighting AIDS, polio and COVID-19.


FILE - In this May 13, 2019, photo, a mirror is held up to Izzle, a rhesus macaque, at Primates Inc., in Westfield, Wis. - Carrie Antlfinger/Copyright 2019 The AP. All rights reserved

In 2003, a nationwide shortage of rhesus macaques threatened to slow down studies and scientists were paying up to 9,000 euros per animal to continue their work.

“Every large research university in the United States probably has some rhesus macaques hidden somewhere in the basement of its medical school,” according to the 2007 book, “Macachiavellian Intelligence: How Rhesus Macaques and Humans Have Conquered the World."

“The U.S. Army and NASA have rhesus macaques too,” wrote the book's author, Dario Maestripieri, a behavioural scientist at the University of Chicago, “and for years they trained them to play computer video games to see whether the monkeys could learn to pilot planes and launch missiles.”

Research begins in the 1890s


Humans have been using the rhesus macaque for scientific research since the late 1800s when the theory of evolution gained more acceptance, according to a 2022 research paper by the journal eLife.

The first study on the species was published in 1893 and described the “anatomy of advanced pregnancy," according to the eLife paper. By 1925, the Carnegie Science Institute had set up a breeding population of the monkeys to study embryology and fertility in a species that was similar to humans.

One reason for the animal's popularity was its abundance. These monkeys have the largest natural range of any non-human primate, stretching from Afghanistan and India to Vietnam and China.

“The other reason is because rhesus macaques, as primates go, are a pretty hardy species,” said Eve Cooper, the eLife research paper's lead author and a biology professor at the University of Colorado-Boulder. “They can live under conditions and they can be bred under conditions that are relatively easy to maintain.”
NASA rockets and the Salk polio vaccine

In the 1950s, the monkey's kidneys were used to make the Salk polio vaccine. NASA also used the animals during the space race, according to a brief history of animals in space on the agency's website.

For example, a rhesus monkey named “Miss Sam” was launched in 1960 in a Mercury capsule that attained a velocity of 1,900 kph and an altitude of 14.5 kilometres . She was retrieved in overall good condition.

“She was also returned to her training colony until her death on an unknown date,” NASA wrote.

Mapping the human genome


In 2007, scientists unravelled the DNA of the rhesus macaque. The species shared about 93% of its DNA with humans, even though macaques branched off from the ape family about 25 million years ago.

In comparison, humans and chimpanzees have evolved separately since splitting from a common ancestor about six million years ago, but still have almost 99% of their gene sequences in common.

The mapping of the human genome in 2001 sparked an explosion of work to similarly decipher the DNA of other animals. The rhesus macaque was the third primate genome to be completed,

‘They’re very political'

For those who have studied the behaviour of rhesus macaques, the research is just as interesting.

“They share some striking similarities to ourselves in terms of their social intelligence,” said Maestripieri, the University of Chicago professor who wrote a book on the species.

For example, the animals are very family oriented, siding with relatives when fights break out, he told The Associated Press on Friday. But they also recruit allies when they're attacked.

“They're very political,” Maestripieri said. “Most of their daily lives are spent building political alliances with each other. Does that sound familiar?"

Maestripieri was a consultant for a reality show about some rhesus macaques in India called “Monkey Thieves.”

“They basically started following large groups of these rhesus macaques and naming them,” the professor said. “It was beautifully done because these monkeys essentially act like people occasionally. So it’s fascinating to follow their stories.”

43 lab monkeys escaped in South Carolina. They have a legal claim to freedom.


Who owns the escaped monkeys now? It’s more complicated than you might think.



by Angela Fernandez and Justin Marceau
Nov 11, 2024
VOX

Monkeys at the Alpha Genesis research facility in Yemassee, South Carolina. Anadolu via Getty Images

Last week, 43 monkeys, all of them young female rhesus macaques, escaped from the Alpha Genesis research laboratory in Yemassee, South Carolina, when an employee failed to properly secure the door to their enclosure.


It wasn’t the first time something like this happened at Alpha Genesis, a company that breeds and uses thousands of monkeys for biomedical testing and supplies nonhuman primate products and bio-research services to researchers worldwide. In 2018, the US Department of Agriculture (USDA) fined the facility $12,600 in part for other incidents in which monkeys had escaped. “We’re not strangers to seeing monkeys randomly,” a nearby resident and member of the Yemassee town council told the New York Times.


Alpha Genesis is now working to recapture the macaques, who are each about the size of a cat; over the weekend, 25 of them were recovered. Meanwhile, the animal protection group Stop Animal Exploitation Now, which for years has filed federal complaints against the facility, has called on the USDA to prosecute Alpha Genesis as a repeat violator of its duty to keep the animals secure.


“The recovery process is slow, but the team is committed to taking as much time as necessary to safely recover all remaining animals,” a Facebook post from the Yemassee Police Department said, attributing the comment to Alpha Genesis CEO Greg Westergaard.


In one way, this is a story about what looks like a corporate failure. But there is another way to understand this situation, both legally and morally. What if these intrepid macaques, who the lab has said pose no threat to the public and carry no infectious diseases, have a legal claim to freedom?


The legal status of wild animals is more contested and malleable than ever, evident in the recent court case arguing that Happy, an elephant living at the Bronx Zoo, was a legal person entitled to freedom, the phasing out of animal use at entertainment venues like circuses, and the end of US lab experimentation on chimpanzees. While Alpha Genesis may have a strong financial incentive to recapture the escaped monkeys, longstanding legal doctrines suggest that the 18 monkeys still at large may not belong to the company as long as they remain free and outside of its custody. State officials, or perhaps even members of the public, might even be legally protected in rescuing these monkeys from a fate of cage confinement and invasive experimentation and bringing them to a sanctuary. Such an outcome would matter not just for these monkeys but also for the rights of captive animals more broadly.

When a captive animal becomes free


For many people, the idea of a lost animal becoming the property of another person might seem absurd. Certainly, no one would imagine forfeiting the companionship of a beloved dog or cat because the animal got out of the yard and was found by someone else. Neither law nor morality treats the escape of a domesticated animal as tantamount to a forfeiture of all claims to the animal.


But when it comes to wild animals, the law is different.


When a captive wild animal escapes, their captor generally remains liable for any damage the escaped animal creates to persons or property, but they may lose ownership of the animal, especially if the creature integrates into an existing wild population (sometimes called “reverting to the common stock”). That might sound unlikely for rhesus macaques in the US — the species is native to South and Southeast Asia and has been exported around the world for lab testing. But it turns out that it’s perfectly possible to live as a free-roaming rhesus macaque in South Carolina, where a more than four-decade-old population of the monkeys resides on the state’s Morgan Island, also known as “Monkey Island.”


Originally relocated from Puerto Rico between 1979 and 1980, the Morgan Island macaques now serve as a kind of reservoir of lab monkeys for the US government. Last year, Alpha Genesis won a federal contract to oversee the monkey colony there — in fact, the 43 escaped macaques had originally lived as “free-range” monkeys on the island before they were taken to be used for testing and research purposes, the US Centers for Disease Control and Prevention told CBS News in a statement. While these monkeys may not be able to rejoin the Morgan Island colony on their own, the fact that they came from a wild population strengthens the view of them as animals who not only can live in the wild but who deserve to be free.

Rhesus macaques on Morgan Island. The State/Getty Images

A macaque sits in a cage in a University of Muenster laboratory in Muenster, Germany, on November 24, 2017. Friso Gentsch/picture alliance via Getty Images


Our modern understanding of animals’ legal status derives from 19th-century American common law cases, which adopted the classical Roman legal approach to wild animals, or ferae naturae. Under that system, wild animals were a special type of property known as “fugitive” property because they could move freely and weren’t owned by anyone before being captured by a human. This created unique legal challenges — for example, conflicts between two hunters claiming the same animal — that can help us understand the case of the escaped monkeys.


The 1805 New York Supreme Court case Pierson v. Post, sometimes considered the most famous property case in American law (and about which one of us has written a book), is the starting point for understanding who legally owns a wild animal. In a dispute between two hunters, one who had been in hot pursuit of a fox and one who swooped in to kill the animal, the case held that the property interest of the latter was stronger. The court made clear that a definitive capture, and not pursuit alone, was necessary to establish and retain ownership of a wild animal.


In 1898, another New York case, Mullett v. Bradley, went further by recognizing that capture alone is not sufficient to claim ownership of a wild animal if the animal is able to escape and regain their liberty. The court found that a sea lion who had been brought by rail from the Pacific Ocean to the East Coast and later escaped from an enclosure in Long Island Sound was legally free until he was captured by a different person two weeks later. Cases like these gave rise to a doctrine that legal scholars now call “the law of capture,” which holds that if a captive wild animal escapes and control over them is lost, they no longer necessarily belong to the party who had previously captured them.


This line of legal reasoning generally works to the detriment of animals, ensuring that each generation of law students learns that animals are ours to possess and use for our own ends. But in the case of the escaped South Carolina monkeys, the law of capture raises doubt about whether the lab retains ownership of the animals unless and until it recaptures them.


A more recent Canadian case suggests that the law of capture may indeed offer a path to rescue for escaped animals like the South Carolina lab monkeys. In 2012, Darwin, a Japanese snow macaque, became a worldwide media sensation when he was found roaming through an Ontario Ikea store wearing a shearling coat and a diaper. While Darwin had been kept as a pet, a Canadian court ruled that he was a wild animal, and his owner lost her rights to him after he escaped from her car. Toronto Animal Services captured Darwin inside the store and transferred him to a primate sanctuary, where he could live among other macaques.


Still, one could argue that the escaped lab monkeys in South Carolina are effectively domestic animals who belong to their owner. Alpha Genesis has put resources into housing and raising them, including managing the monkey population on Morgan Island. But unlike pets who have been domesticated over many generations to live safely among humans, these rhesus macaques retain their wild instincts — they’ve been described as skittish, and food is being used to lure them into traps.


If the monkeys were to return on their own, like a house cat coming home after a day of adventure, the legal case for viewing them as domestic animals would be stronger because wild animals, once they stray, must have no animus revertendi, or intention to return. So long as these monkeys express their desire to remain free by evading capture, they should be considered wild animals. A 1917 Ontario court case, Campbell v. Hedley, involving a fox who had escaped a fur farm, established a similar principle, finding that the animal remained wild and thereby became free after fleeing the farm because they belonged to a species that “require[d] the exercise of art, force, or skill to keep them in subjection.”


There are, to be sure, cases in which common law courts have found losing control of an animal does not result in a loss of ownership. A 1927 Colorado case, Stephens v. Albers, held that a semi-domesticated silver fox who escaped from a fur farm still remained the property of that owner. And questions about the ownership of wild animals are infinitely debatable, as any good student of Pierson v. Post will tell you.


While these past cases offer important insight into the treatment of wild animals under common law, none of them took place in South Carolina, so courts in that state could consider them for guidance but wouldn’t be required to follow them when deciding who owns the escaped Alpha Genesis monkeys (and nothing in this piece should be construed as legal advice).

The moral meaning of animal escapes


Yet the law of capture aside, the plight of these monkeys is also interesting to us as legal scholars because it highlights one of many disconnects between the law and our moral intuitions about animals who have escaped and who are seeking or being afforded sanctuary. As journalist Tove Danovich has written, there is often great public sympathy and compassion for animals who escape painful confinement or slaughter at zoos, factory farms, or research labs — even among people who might otherwise tolerate the very systems that normalize those animals’ suffering. The public’s outrage when a single cow who escapes slaughter is gunned down by authorities is palpable and crosses ideological lines.


There is something enchanting and powerful, even romantic, about the idea of an animal escape, especially if it results in the animal’s rescue from confinement. Yet the law generally fails to recognize the moral tug that these escapes place on our collective conscience.


In a recent high-profile case in upstate New York, two cows wandered onto an animal sanctuary after escaping from a neighboring ranch. Unlike the South Carolina monkeys, these were straightforwardly domesticated animals, and the response from local law enforcement was harsh.


The sanctuary owner, Tracy Murphy, was arrested, shackled, and faced criminal liability for taking the cows in and refusing to immediately turn them over for slaughter (one of us, Justin, was defense counsel for Murphy, whose case was dismissed last month after a two-year legal battle). Her aid to two escaped cows was widely vilified by her neighbors and by local law enforcement because our legal system continues to treat many animals as property without any recognized rights or interests of their own.


The law is unlikely to swiftly abandon the archaic notion of human ownership over nonhuman animals. But we believe the law does implicitly recognize a right to rescue escaped animals, at least those who are lucky enough to make it on their own steam. We hope that the case of the escaped South Carolina monkeys will inspire conversations about the right of at least some animals to liberate themselves from exploitation and harm at human hands. Escapes are rare, but when they happen against all odds, we might ask ourselves, on both legal and moral grounds, whether the animals have a claim to freedom.


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