LA REVUE GAUCHE - Left Comment: 420

Note the Time. Instead of 420 being a reference for pot maybe it should be used for LSD.

And Lucy In the Sky with Diamonds (LSD) is now officially 64.

At 4:20 in the afternoon, on April 19th, 1943, the Swiss chemist Albert Hofmann deliberately ingested 250 micrograms of LSD-25, a substance he had discovered during experiments with alkaloids of the fungus ergot.

Despite the vanishingly small dosage, he soon found himself stricken with dizziness, euphoria, and an inescapable compulsion to laugh. Within the hour, he could barely write or speak intelligibly, and fearing he'd poisoned himself, rode his bicycle to his nearby home, called a doctor, asked for a glass of milk and collapsed on a sofa. What happened next is best described by Hofmann himself, from his autobiographical book, LSD - My Problem Child:
After a doctor arrived and examined him, finding no physical abnormalities besides extremely dilated pupils, Hofmann realized he wasn't in danger of losing his mind or dying and his experience suddenly took a turn for the better:

Now, little by little I could begin to enjoy the unprecedented colors and plays of shapes that persisted behind my closed eyes. Kaleidoscopic, fantastic images surged in on me, alternating, variegated, opening and then closing themselves in circles and spirals, exploding in colored fountains, rearranging and hybridizing themselves in constant flux. It was particularly remarkable how every acoustic perception, such as the sound of a door handle or a passing automobile, became transformed into optical perceptions. Every sound generated a vividly changing image, with its own consistent form and color.

H/T to Access to Awareness

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