Sunday, February 07, 2021

ROARING TWENTIES REDUX
'The only option to grow your money': 
Why new investors bought stock during the pandemic

Susan Tompor, Detroit Free Press
Sun, February 7, 2021

The ability to put just a few extra bucks into stocks. A pandemic panic that drove stock prices way down for many companies that have a future ahead. Easy to use apps.

And throw in a little extra cash via government stimulus checks and some extra time when major league sports teams stopped playing during the pandemic, you couldn't see a movie at a theater and college graduates started working remotely back home.

All of those factors contributed to growth among new investors in 2020.

Sure, many of us who are accustomed to setting aside a little bit of each paycheck in our 401(k) plans didn't see this one coming. Maybe we heard a college student in the family talking about stock picks. We certainly couldn't help but notice as we watched the GameStop battle unfold in the headlines in January.
A man wears a mask as he passes the New York Stock Exchange, Monday, March 9, 2020. The dizzying action in financial markets escalated Monday as stocks moved closer to a bear market and oil prices fell the most since 2008.More

But now you've got to wonder who are all these new investors, many times younger investors, who seem to have some power to move markets?
'Perfect storm' for new investors

More than 10 million new brokerage accounts were opened by individuals in 2020 — more than ever in a year, according to an estimate by Devin Ryan, equity research analyst at JMP Securities.

Last year created the "perfect storm" for investing, Ryan wrote. The brokerage industry moved toward zero on commission rates late in 2019, making it less expensive to invest, and there was an "unprecedented backdrop created by the COVID-19 pandemic."

We saw extreme market volatility, more people working from their home offices and kitchen tables, and more digital transformation, including the customer's willingness to trade stocks via brokerage apps.

Hezekiah Lockridge, 21, opened his first brokerage account in late 2020 after his mentor at his company, Citizens Bank, suggested that he try out the stock market. He uses a brokerage app.

He owns one stock, Apple, and plans to invest in other stocks, possibly in a smaller upstart, at some point. He has about $2,000 in a brokerage account, half in Apple.
Hezekiah Lockridge, 21, began investing in late 2020. He says: "The stock market is the only option to grow your money."

Lockridge graduated in December 2019 from the University of Michigan-Dearborn with a degree in finance. And he remembers going to school and hearing it drilled into his head that people need to save for retirement early in life and take some risks to be able to retire comfortably at age 65.

"Right now, having it in a savings account doesn't get you anywhere," said Lockridge, who lives at home in Ypsilanti, Michigan, and works remotely.

Low interest rates, even with CDs, aren't very helpful to savers.

"The stock market is the only option to grow your money."
New investors are younger, more diverse

A newly released report called "Investing 2020: New Accounts and the People Who Opened Them" outlines some interesting trends.

New investors tend to be young, lower income and more racially and ethnically diverse, according to the collaboration by the FINRA Investor Education Foundation and NORC at the University of Chicago.

The study was done in October 2020 after the market meltdown in March but before the wild show in January where everyone watched the battle between the hedge funds and everyday traders.

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GameStop's stock price hit $483 a share in trading on Jan. 28. The videogame seller closed at $325 a share on Jan. 29 — its highest price after a social media frenzy where investors on Reddit's WallStreetBets drove the stock higher and higher.

Back in early October, GameStop was trading around the $9 a share range.

But the first week of February proved to be brutal with GameStop trading around $70 a share.

The research involved surveying 1,291 households from NORC’s probability-based panel. The survey was fielded between Oct. 26 and Nov. 13, 2020.

Based on the survey, 57% of the respondents opened a new taxable investment account in 2020. Among investors who opened a new account in 2020 in the sample, 66% were new investors who had not previously owned a taxable investment account, making this their first experience buying stocks in a taxable account.

Here's a look at some stats:


The majority of new investors are white. But the report indicated that 17% of new investors last year were Black, while 15% were Hispanic/Latino and 10% were Asian.


About 33% of the account balances for new investors had less than $500. This is money outside of any 401(k) or tax-favored retirement account. If you break it down to new adult investors who are younger than 30, the study indicates that 41% had less than $500 in stocks in taxable accounts.


Many new investors aren't making anything close to six figures. The study noted 24% of new investors earned less than $35,000. That compares with 7% who are experienced investors who opened a new account in 2020 but had an investing account earlier.

Many factors are helping those who don't have big paychecks to play the market. The hurdle isn't as high as it was years ago now that several brokerages offer no-minimum and low-minimum balance brokerage accounts. No-commission trades cut down an investor's cost, too.

"Some of these new brokerages have offered opportunities to enter the stock market that haven't been there before," said Angela Fontes, vice president of Behavioral and Economic Analysis and Decision-making at at NORC at the University of Chicago.

Many communities that have been under-represented in investing, including Black households and Hispanic/Latino households, are able to invest and open a brokerage account without having $25,000 or so to invest, as they might have needed in the past, she said.
Why are newcomers investing?

While many were shaking in their boots about what could happen next to their 401(k)s in March, many younger investors decided to take a chance and shop for possible bargains.

Joseph Mutone, 22, said he decided to buy stocks when he heard the market was crashing back in March 2020 as fear of the pandemic's impact on the U.S. economy flourished.

Mutone, who graduated with a degree in music from the University of Michigan in Ann Arbor in May, said he first opened a brokerage account in 2019. But he didn't do any investing.
Joseph Mutone, 22, of Bloomfield Township, said the market meltdown at the start of the pandemic motivated him to look for bargain prices for stocks in early 2020.More

The app remained on his phone and the market meltdown motivated him to reactivate that account.

"I didn't do too bad," said Mutone, who is now working toward a master of accounting degree at Oakland University and working as a tax intern for PwC.

He bought stock in ONEOK, an owner of one of the nation’s premier natural gas liquids systems, at around $27 a share in mid-March last year. It was trading around $42.50 a share in early February — a gain of around 57% in less than a year.

Mutone, who lives in Bloomfield Township with his parents, said he started investing with less than $3,000. He had saved the money from his job working as a church organist.

He does his own research and uses the Seeking Alpha app for news and information. He talks with his dad about his strategies.

"People are starting to see there is a lot of benefit to investing," Mutone said. "I've been getting calls from my friends asking me how do you get started."

Some younger investors seem to add a social component to investing, Fontes said.

The report noted that 51% of people age 18 to 29 years old said they opened a new investment account in 2020 after receiving a suggestion from a friend. And 31% acted after a suggestion from a family member.

Mark Lush, manager and behavioral scientist in the Behavioral and Economic Analysis and Decision-Making team at NORC at the University of Chicago, said the big dip in the stock market at the beginning of the pandemic drove a lot of interest in stocks.

People who opened new brokerage accounts in 2020 gave three common reasons: The ability to invest with a small amount of money (35%), wanting to invest for retirement (27%), and dips in the market that made stocks cheaper to buy (26%).

And 19% reported that they had received some money, perhaps including stimulus cash, that gave them extra cash to invest. About 12% said they had money from a sign-up bonus.
What are the risks ahead?

On the downside, experts say, research indicates that there's a lower level of investor literacy among new investors who opened a taxable account for the first time in 2020.

"What we're seeing is they're actually saying one of the actual reasons they're opening an account is to learn about investing, which is sort of interesting," Fontes said. "This is one of the goals."

On the one hand, you might find it odd that people risk their money perhaps before learning about investing. But I understand the logic, especially if you're putting a small amount of money at risk.

I'm not a wonderful baker or cook, like my mother or sister. Over years, though, I've learned quite a bit. And I didn't learn how to bake lemon bars or cook chili just by reading a recipe.

If you want to bake or cook, you've got to make discoveries along the way and deal with a few flops. (Key tip: Adding some chopped chipotle peppers to a recipe does not mean the recipe calls for dumping in an entire can.)

With anything, it is important to keep learning and try to correct any mistakes along the way.

New investors more frequently relied on the advice of friends and family, instead of financial professionals or their own personal research. But many used a variety of information sources, as well.

The survey noted that 14% of brand new investors turned to social media when making investment decisions; 27% turned to the news media and 38% turned to friends and family.

And 10% of new investors said they turned to online chats to get stock tips and investing advice.

"Those numbers might be a little higher now," Gary Mottola, FINRA Foundation research director, said referring to the publicity that online sites like Reddit's WallStreetBets received as part of the GameStop frenzy.

More financial literacy is needed. A free e-learning program for new investors is at www.finra.org/investors/learn-to-invest.

"It's really important for new investors to understand risk," Mottola said.

Mottolla told me that some new investors are showing a bit of a disconnect between their goals and their game plans.

More than half of new investors, Mottola noted, said they were buying stocks as a way to save money for retirement.

But oddly enough, the new investors are using taxable, non-retirement accounts to invest. They could be missing out on the important tax breaks offered to retirement savers who set aside money in a 401(k) plan, a Roth IRA or a traditional IRA.

And 23% said they're saving for an upcoming expense, such as paying for a wedding or buying a car. Yet are those investors underestimating the short-term risks and overlooking the real possibility that they could lose a good deal of their money in the short term if stock prices fall?

A key investment tip: You shouldn't sacrifice money you can't afford to lose, if you're chasing short-term returns.

Mottola noted that most investors reported they were willing to take average financial risks expecting to earn average returns. But they might have been taking on greater risk than they realized.

Most new investors (64%) were taking on greater risk by using their brokerage accounts to buy individual company stocks, not more broadly diversified mutual funds. Only 28% of new investors were using the brokerage accounts to buy mutual funds.

You've got to know your goals and get a game plan that will get you there.

Contact Susan Tompor via stompor@freepress.com. Follow her on Twitter @tompor.

This article originally appeared on Detroit Free Press: Stock market flooded with new investors during COVID-19
POST FORDISM
Vietnam's Vinfast gets permit to test self-driving vehicles in California

Sun, February 7, 2021

HANOI, Feb 8 (Reuters) - Vietnam's first domestic car manufacturer, Vinfast, said on Monday it had obtained a permit to test autonomous vehicles on public streets in California.

 te Vin group JSC, said the permit granted by the California Vehicle Administration was needed in order for the firm to commercialize its electric vehicles in the U.S. market.

Vinfast said it has developed three models with autonomous features, adding that two of the models would be sold in the U.S., Canadian and European markets from 2022.


Last year, Vinfast said it had bought GM Holden's Lang Lang Testing Centre in Australia following its move to open a research and develop centre in Melbourne, as part of its efforts to expand internationally.

(Reporting by Khanh VuEditing by Ed Davies)
Ecuador to Hold Election Runoff After Socialist Wins First Round

Stephan Kueffner
Sun, February 7, 2021



(Bloomberg) -- A socialist economist feared by bond investors won the first round of Ecuador’s presidential election, and will face either an environmentalist or a wealthy banker in a runoff after an unexpected fight for second place.

Andres Arauz, who rejects austerity measures and attacked Ecuador’s deal last year with the International Monetary Fund, got 31.5% of votes cast, according to the quick count published by the electoral authority late on Sunday.

The race for second place is still too close to call. In the fast count, Yaku Perez, from the indigenous party Pachakutik, got 20.04%, giving him a wafer-thin lead over the conservative Guillermo Lasso, who got 19.97%.

Perez opposes mining projects and wants to renegotiate Ecuador’s debt, while Lasso backed the IMF deal and wants the country to have warm relations with Washington. The result confounded polls, which mostly predicted that Lasso would comfortably make the second round.

Once the final vote has been tallied, either Perez or Lasso will face Arauz in the second round, scheduled for April 11.

Arauz’s strong showing means that the nation’s dollar bonds “will definitely be weaker on Monday,” said Siobhan Morden, head of Latin America fixed income strategy at Amherst Pierpont in New York.

The campaign for control of Ecuador, an oil exporter and world-leading producer of bananas, shrimp, and the balsa wood crucial for wind-turbine rotors, has become a battleground of international interests.

Arauz, 36, is a protege of exiled former leader Rafael Correa, who allied the country with the socialist governments of Venezuela and Cuba and who often had an acrimonious relationship with Washington.


©2021 Bloomberg L.P.

TAX AVOIDANCE

Amazon criticised in paying lower rates than UK shops

A woman wearing a mask accepts an Amazon package
A woman wearing a mask accepts an Amazon package

Amazon has been criticised for paying less in business rates than British bricks and mortar retailers.

The online retail giant's financial results revealed that UK sales for 2020 totalled $26.5bn (£19.3bn) - a 51% jump from $17.5bn in 2019.

Amazon's overall business rates bill for 2020-2021 is estimated by researchers to be £71.5m - just 0.37% of its retail sales.

They say this is far lower than what the retail sector typically pays.

Amazon insists that it pays its tax and has created thousands of jobs in the UK.

Business rates are calculated by looking at a property's rateable value and multiplying it by a tax rate set by the government. A new tax rate comes into effect at the start of each financial year on 1 April.

According to figures from the Office for National Statistics (ONS), full-year retail sales at physical shops for the 12 months ending 31 December 2020 fell 10.3% from £318.5bn in 2019 to £285.8bn.

Retail advisor Altus Group says that bricks and mortar retailers would have paid £8.25bn in business rates in 2020, had they not been given a tax holiday due to the pandemic.

It says the figure was calculated using rateable values, multiplied by the 2020 tax rate. The £8.25bn figure amounts to 2.9% of total retail sales, which is much higher than what Amazon pays.

For instance, Arcadia - which owns Topshop, Burton and Dorothy Perkins - would have had to pay £91m in business rates on its 444 stores in 2020, had there not been a tax holiday, Altus Group says.

Topshop store
Without the business rates holiday, Arcadia Group would have paid £91m in taxes on its 444 stores in 2020, says Altus Group

A Treasury spokesman said: "We want to see thriving high streets, which is why we've spent tens of billions of pounds supporting shops throughout the pandemic and are supporting town centres through the changes online shopping brings.

"Our business rates review call for evidence included questions on whether we should shift the balance between online and physical shops by introducing an online sales tax. We're considering responses now."

Separately, the Centre for Retail Research (CRR) calculated the business rates paid by physical shops in 2019 and found that they paid £7.17bn in business rates, or 2.3% of their total retail sales in 2019.

The two organisations said that Amazon, which has close to 100 sites in the UK, including distribution warehouses and lockers on High Streets, is not paying enough tax.

However, their calculations do not include corporation tax, which is currently at 19% of profits.

Debate over digital services tax

Amazon would not comment on the calculations made by Altus Group and CRR.

A spokesman for Amazon said: "We've invested more than £23bn in jobs and infrastructure in the UK since 2010.

"Last year we created 10,000 new jobs and last week we announced 1,000 new apprenticeships. This continued investment helped contribute to a total tax contribution of £1.1bn during 2019 - £293m in direct taxes and £854m in indirect taxes."

The government is currently reviewing the way in which the business rates system works, and is also separately considering a 2% tax on online sales and services.

But business lobby group the Confederation of British Industry (CBI) has warned that any tax rises would place additional pressure on businesses that are already struggling due to the pandemic.

CRIMINAL CAPITALI$M
Taiwan punishes Deutsche Bank, others in currency speculation case

Sat, February 6, 2021

FILE PHOTO: Staff member stands beside the Taiwanese Central Bank logo in Taipei

TAIPEI (Reuters) - Taiwan's central bank said on Sunday it had banned Deutsche Bank from trading Taiwan dollar deliverable and non-deliverable forwards and suspended it for two years from trading forex derivatives as part of a crackdown on speculation.

The Taiwan dollar is at a more than 23-year-high against the U.S. dollar as the island's trade-dependent economy booms on global demand for its tech products as people work from home. The central bank has been particularly concerned about a case where it said foreign banks helped grain companies engage in currency speculation through deliverable forwards, affecting the stability of Taiwan's foreign exchange market.

Sources told Reuters on Friday that the central bank had sent letters outlining punishments to Deutsche Bank, CitigroupInc, ING and Australia and New Zealand Banking Group Ltd (ANZ) for their involvement.

Apart from the punishment for Deutsche Bank's Taipei branch, the central bank said in statement that ING and ANZ's Taipei offices would not be allowed to trade Taiwan dollar deliverable and non-deliverable forwards for nine months.

Citi's Taipei office would be suspended from trading Taiwan dollar deliverable forwards for two months, it added.

Citi and ANZ declined to comment. Representatives for the other two banks did not immediately respond to a request for comment.

The punishments will come into effect on Monday, the central bank added.

Eugene Tsai, head of the central bank's foreign exchange department, told Reuters that transactions made by the banks in accordance with the rules before Friday had been completed on schedule.

He added that the punishment against Deutsche meant it would not be able to trade forex options or swaps.

The central bank announced its probe into the case last month, which it said involved eight grain-trading companies.

(Reporting by Liang-sa Loh and Ben Blanchard; Editing by Christian Schmollinger and Kim Coghill)


Taiwan Penalizes Deutsche Bank, 

3 Others for Currency Trades

Cindy Wang and Miaojung Lin

(Bloomberg) -- Taiwan penalized Deutsche Bank AG and three other foreign lenders after a probe into speculation on the surging local currency last year involving grain companies.

Deutsche Bank’s trading approvals for Taiwan dollar deliverable forwards and non-deliverable forwards will be revoked, and it will be banned from engaging in transactions of foreign exchange derivatives for two years, the island’s central bank said in a statement Sunday.

ING Groep NV and Australia & New Zealand Banking Group Ltd. won’t be allowed to engage in Taiwan dollar deliverable forwards and non-deliverable forwards trading for nine months, while Citigroup Inc. is banned from Taiwan dollar deliverable forwards trading for two months, the central bank said. The penalties imposed on the local units will take effect on Monday.

The banks were notified of the punishments on Friday. Trades made before the notice won’t be affected, the central bank said.

Citigroup declined to comment. Deutsche Bank, ING and ANZ didn’t immediately respond to calls seeking comment outside of business hours.

Eight of Asia’s leading food traders, with the help of six overseas banks, built a combined $11 billion in their Taiwan dollar deliverable forwards positions as of the end of July, the central bank said last month. The positions were based on overseas physical grain trades deliberately transacted via their Taiwan units to speculate on the local currency, affecting market stability, it said.

Cargill Inc. and Louis Dreyfus Co. were involved, along with Deutsche Bank, Citigroup, JPMorgan Chase & Co. and Standard Chartered Plc among others, Bloomberg News reported in January, citing people with knowledge of the matter. At least some of the trades were specifically designed to profit from the rising Taiwan dollar, the people familiar said.

The island’s dollar has strengthened almost 7% against the U.S. dollar over the past 12 months, among the region’s top performers, according to Bloomberg data.

The central bank settled with two lenders in November, it said Sunday, without identifying them. The six banks violated rules because the forwards trades had to be made based on their actual needs, the central bank said Sunday.

Deutsche Bank can reapply for the revoked trading approvals in the future depending on improvements, according to Eugene Tsai, the central bank’s director general of the Department of Foreign Exchange.

Taiwan’s central bank tightly regulates how much of its dollars foreign companies can accrue to avoid speculation on the currency. It had said the huge positions the commodity companies built up in deliverable forwards went beyond their actual business needs.

(Updates with probe from fifth paragraph.)

For more articles like this, please visit us at bloomberg.com


 

 ROARING TWENTIES REDUX

The GameStop Phenomenon Is Hardly New. Here’s How a Similar Squeeze Played Out in 1923.


Piggly Wiggly’s innovative “self-service” grocery store in Tennessee, circa 1918.

Library of Congress

Long before GameStop, there was Piggly Wiggly.

In 1923, the supermarket company—which still does business in the South and Midwest—was at the center of a short squeeze/market morality play that echoes the recent frenzy around GameStop.

As with GameStop and other “meme” companies like AMC Entertainment, Piggly Wiggly was being sold short...

The GameStop Phenomenon Is Hardly New. Here’s How a Similar Squeeze Played Out in 1923. | Barron's

Piggly Wiggly - Wikipedia

https://en.wikipedia.org › wiki › Piggly_Wiggly

Piggly Wiggly is an American supermarket chain operating in the Southern and Midwestern regions of the United States, run by Piggly Wiggly, LLC, an affiliate of C&S Wholesale Grocers. Its first outlet opened in 1916 in Memphis, Tennessee, and is notable for having been the first true self-service grocery store, and the originator of various familiar supermarket features such as checkout stands, individual item price marking and shopping carts. The current company headquarters is in Keene, New Hampshire. 


Carlsberg predicts surge in demand similar to Jazz Age

boom

Richard Milne, Nordic and Baltic Correspondent

Carlsberg is expecting a surge in demand this summer similar to a boom seen a century ago as more people are vaccinated and lockdowns lift, according to the Danish brewer’s chief executive. In the 1920s, after Spanish Flu and [the] first world war, there was a dramatic surge and you saw things like jazz clubs and ballroom dancing. Its global sales to pubs, restaurants and hotels fell by 20 per cent owing to lockdowns and although revenues from shops increased, it was not enough to compensate.

Carlsberg predicts surge in demand similar to Jazz Age boom (yahoo.com)

Jazz Age - Booming 1920s

https://booming1920sg2.weebly.com › jazz-age.html

The Jazz Age is another title for the 1920's. When women became more independent. They were becoming more sexually appealing. They were arrested for wearing "skimpy" beach wear. During this time Jazz was becoming more popular. People would dance in the streets all night till everyone dropped to floor. Women would go to all night parties.

Rolls-Royce plans two-week shutdown of civil aerospace business

Sun, February 7, 2021

File photo of an Airbus A350 with a Rolls-Royce logo at the Airbus headquarters in Toulouse

(Reuters) - Britain's Rolls-Royce said on Sunday it is proposing a two week operational shutdown of its civil aerospace unit over the summer as it manages costs due to the impact of the COVID-19 pandemic.

The aero-engine maker has begun talks with unions on the shutdown and cost cutting at its civil aerospace unit, it said in an emailed statement.

"As we continue to manage our cost base in response to the ongoing impact of the COVID-19 pandemic on the whole commercial aviation sector, we are proposing a two week operational shutdown of Civil Aerospace over the Summer," it said.

Rolls-Royce's finances have been hit by the COVID-19 crisis as its airline customers have grounded planes. It warned last month that travel would be even more constrained than expected this year, leading to increased cash outflow.

(Reporting by Anirudh Saligrama and Sabahatjahan Contractor in Bengaluru; Editing by Alexander Smith)




How Scientists Shot Down Cancer's 'Death Star'

Gina Kolata
Fri, February 5, 2021, 

After 40 years of effort, researchers have finally succeeded in switching off one of the most common cancer-causing genetic mutations in the human body. The finding promises to improve treatment for thousands of patients with lung and colorectal cancer, and may point the way to a new generation of drugs for cancers that resist treatment.

The finding has already led to a new medication, sotorasib, by drugmaker Amgen. Other companies are close behind with their own versions.

Amgen tested its drug in patients with the most common type of lung cancer, called non-small cell cancer. The disease is diagnosed in 228,000 Americans a year, and for most patients in the advanced stages, there is no cure.

The new drug attacks a cancer-causing mutation, known as KRAS G12C, that occurs in 13% of these patients, almost all of whom are current or former smokers. Sotorasib made the cancers shrink significantly in patients with the mutation, Amgen reported last week at the World Conference on Lung Cancer.

On average, tumors in the patients stopped growing for seven months. In three out of 126 patients, the drug seems to have made the cancer disappear entirely, at least so far, although side effects included diarrhea, nausea and fatigue.

It already is routine to test lung cancer patients for the mutation, because they are often resistant to other drugs, said Dr. John Minna, a lung cancer specialist at the University of Texas Southwestern Medical Center in Dallas.

Amgen’s drug is not as drastically effective as some new cancer medicines, said Dr. Bruce Johnson, chief clinical research officer at the Dana-Farber Cancer Institute in Boston. But in combination with other drugs, those targeting specific mutations can change the course of the disease in many patients, he added.

For example, drugs targeting specific mutations in melanoma patients at first seemed unimpressive, but when combined with other medicines, they eventually changed prospects for patients with this deadly disease.

“The more I looked at it, the more optimistic I became,” Johnson said of Amgen’s new data.

While the KRAS G12C mutation is most common in lung cancer, it also occurs in other cancers, especially in colorectal cancer, where it is found in up to 3% of tumors, and particularly in pancreatic cancer. KRAS mutations of some type are present in 90% of pancreatic tumors.

How the off-switch was discovered is a story of serendipity and persistence by an academic chemist who managed the seemingly impossible.

In 2008, that chemist, Kevan Shokat, a professor at the University of California, San Francisco, decided to focus on the mutated gene. It had been discovered 30 years earlier in rats with sarcomas, a type of cancer that begins in bones and soft tissues.

Researchers found the mutation in human tumor cells, and then discovered that it was one of the most frequently mutated genes in cancers of many types. Different cancers tend to spring from different mutations in the KRAS gene and the protein it encodes. The G12C mutation occurs mostly in lung cancers.

The search for drugs to block previously discovered cancer-causing mutations was always straightforward: Researchers had to find a molecule that attached to the mutated protein and could stop it from functioning. That strategy worked for so-called kinase inhibitors, which also block a protein created by gene mutations. There are 50 approved kinase inhibitors on the market now.

KRAS was different. The gene directs production of a protein that normally flexes and relaxes thousands of times a second, as if it is panting. In one position, the protein signals cells to grow; in the other, it stops the growth. With the KRAS mutation, the protein remains mostly in an “on” position, and cells are constantly forced to grow.

The standard solution would be a drug that would hold the mutated protein in the “off” position. But that seemed impossible. The protein is large and globular, and it doesn’t have deep pockets or clefts on its surface where a drug could slip in. It was like trying to drive a wedge into a ball of solid ice.

“Our medicinal chemists referred to it as the Death Star,” said Dr. David Reese, executive vice president for research and development at Amgen. “It was so smooth.”

So Shokat and his colleagues began looking for a molecule that could do the trick. Five years later, after screening 500 molecules, they found one and discovered why it worked.

Their drug held the protein steady, making a crevice visible on its surface. “We never saw that pocket before,” Shokat said. The protein normally flexes and relaxes so quickly that the narrow groove had almost been impossible to see.

There was more good news. The drug attached itself to cysteine, an amino acid that occurs in the groove only because of the KRAS mutation. The drug worked only against the mutated protein, and therefore only against cancer cells.

“It is really specific,” Shokat said. “That’s what’s amazing.” He published his findings in 2013, causing a sensation in the field.

Reese, of Amgen, said that the data “gave us the proof that we could actually do this,” and that “it silenced many of the doubters.”

Shokat, too, began working on a drug, which is now being developed by Johnson and Johnson. At least eight companies have their own KRAS inhibitors in clinical trials.

Lung cancer is only the beginning, Shokat said. The next challenge is pancreatic cancer, one of the most lethal types: “KRAS is the signature mutation for pancreatic cancer,” he added.

Most patients have such a mutation, and while it makes the disease very difficult to treat, now it may also make the cancer particularly vulnerable. Researchers have already found drugs that seem promising.

This article originally appeared in The New York Times.

© 2021 The New York Times Company