Saturday, October 28, 2023

 

AI tool outperforms prior methods in colorectal cancer analysis


Peer-Reviewed Publication

UNIVERSITY OF JYVÄSKYLÄ - JYVÄSKYLÄN YLIOPISTO

Each dot represents an image piece from a cancer microscope slide. 

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EACH DOT REPRESENTS AN IMAGE PIECE FROM A CANCER MICROSCOPE SLIDE. THE AI SYSTEM HAS AUTOMATICALLY ARRANGED THEM BY SIMILARITY.

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CREDIT: FABI PREZJA




Researchers from the University of Jyväskylä in collaboration with the Institute of Biomedicine University of Turku and Nova Central Finland have developed an artificial intelligence tool for automatic colorectal cancer tissue analysis. The refined neural network outperformed all previous solutions in the task. The neural network offers a faster, more precise method for classifying colorectal cancer tissue images from microscope slides. This could significantly reduce the workload of histopathologists, leading to quicker insights, prognoses, and diagnoses.

Public Accessibility for Future Advancements

In a significant nod to open science and cooperative growth, the researchers are making the trained neural network tool available to the public. This gesture is intended to spur further advancements by inviting scientists, researchers, and developers globally to refine its capabilities and investigate new applications. 

“By granting universal access, the aim is to fast-track breakthroughs in colorectal cancer research”, adds Fabi Prezja, who was responsible for the design of the method.

Stringent Clinical Validation is Imperative

While the results are promising, it's crucial to adopt AI in clinical settings judiciously. The calibre and diversity of medical data are central to the success of AI-driven methods. As these AI solutions inch closer to routine clinical implementation, it's imperative they undergo stringent clinical validation to ensure their outcomes consistently align with clinical standards.

 

 

People with severe mental illness at 50 per cent higher risk of death following COVID-19 infection

Peer-Reviewed Publication

KING'S COLLEGE LONDON

New research from King’s College London has found that in the UK people with severe mental illness were at increased risk of death from all causes following COVID-19 infection compared to those without severe mental illness.

Published in the British Journal of Psychiatry, the study investigated the extent to which having severe mental illness, which includes schizophrenia and psychosis, increased the risk of death during the first two waves of the COVID-19 pandemic.

Researchers at the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) and ESRC Centre for Society and Mental Health analysed data from over 660,000 UK patients between February 2020 and April 2021.

Among the 7146 people with severe mental illness, there was a 50 per cent greater risk of death from all causes following COVID-19 infection compared with those without severe mental illness.

Black Caribbean/Black African people were at a 22 per cent higher risk of death following COVID-19 infection than White people, and this was similar for people with and without severe mental illness. However, in around 30 per cent of patient data, ethnicity was not recorded.

The study revealed regional differences: on average, risk of death following COVID-19 infection was higher among Northern UK regions compared to Southern regions. Those in Northern Ireland, the East Midlands and the North-East were at between 24 – 28 per cent increased risk of death compared to those in London.

Dr Alex Dregan, senior author and Senior Lecturer in psychiatric epidemiology at King’s IoPPN said: “We are the first group to use the Clinical Practice Research Datalink to understand the impact of COVID-19 on premature morbidity among people with severe mental illness, making this one of the largest studies of its kind Previous research has shown that these health inequalities exist but our study really demonstrates how the pandemic has exacerbated them. We now need to try to understand why this is happening and see if there is a pattern in how these people do or do not seek and access services.”

The research also found that those with more than one long-term health condition (multimorbidity) were at greater risk of death: for each additional long-term health condition, the risk of death increased by six per cent for people with severe mental illness and 16 per cent for people without severe mental illness following COVID-19 infection.

The study is part of a Health Foundation funded project called COVID-19 Ethnic Inequalities in Mental health and Multimorbidities (COVE-IMM) that is using both quantitative and qualitative methods.

Principal investigator on the COVE-IMM project and co-lead of the platform for cohorts and quantitative methods at the ESRC Centre for Society and Mental Health, and lead author Dr Jayati Das-Munshi said:

“These are stark findings and highlight the health inequalities that exist for people living with severe mental illness, people from racialised groups and people from different regions of the country. We still need to learn more about the experiences of these groups which we are doing through in-depth interview research and we also need to understand the gap in how our services provide for these vulnerable people. The pandemic shone a light on these inequalities, and we must learn from this to develop new policies and improve service provision.” 

The data was from the Clinical Practice Research Database – one of the world’s largest clinical research databases containing over 60 million anonymised electronic primary care records. Researchers were part of the ESRC Centre for Society and Mental Health, the National Institute for Health and Care Research (NIHR) Applied Research Collaboration (ARC) South London and the NIHR Maudsley Biomedical Research Centre.

 

Central Illinois named US Tech Hub for biomanufacturing by Biden-Harris administration



Business Announcement

UNIVERSITY OF ILLINOIS COLLEGE OF AGRICULTURAL, CONSUMER AND ENVIRONMENTAL SCIENCES

iFAB Tech Hub 

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BETH CONERTY, CARLY MCCRORY-MCKAY, AND NICOLE BATEMAN (L-R) HELPED FORM THE IFAB TECH HUB TO SPUR ECONOMIC GROWTH AND JOB CREATION IN CENTRAL ILLINOIS THROUGH BIOMANUFACTURING AND PRECISION FERMENTATION.

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CREDIT: ANNA LONGWORTH PHOTOGRAPHY




URBANA, Ill. — President Joe Biden announced Monday that the Illinois Fermentation and Agriculture Biomanufacturing Hub (iFAB) is among 31 designated Regional Innovation and Technology Hubs (Tech Hubs) by the U.S. Economic Development Administration (EDA) — recognizing Central Illinois as a globally competitive center for innovation and job creation in biomanufacturing.

Led by the Integrated Bioprocessing Research Laboratory (IBRL) at the University of Illinois Urbana-Champaign, the iFAB consortium includes 30 partner organizations representing academic, industry, government, and nonprofit partners committed to catalyzing industry growth in Champaign, Piatt, and Macon counties. 

“The iFAB designation leverages IBRL’s five years of operational success. Companies come here to prove their technologies, and our aim is for them to remain in the region and establish early manufacturing facilities to progress from ideation to commercialization,” said iFAB principal investigator Beth Conerty, the Associate Director of Business Development at IBRL, part of the College of Agricultural, Consumer and Environmental Sciences and The Grainger College of Engineering

The EDA Tech Hubs program was authorized by the bipartisan CHIPS and Science Act of 2022 with the goal to boost economic growth, spur job creation, and ensure U.S. national security. 

The precision fermentation industry is projected to reach $11.8 billion by 2028, with the potential to generate one million jobs by 2030. The EDA’s Tech Hub designation elevates the reputation and confidence needed to attract more funding, resources, companies, and talent in this space to Central Illinois. 

Precision fermentation is a growing area of biomanufacturing that can turn local feedstocks, mainly corn and soybeans, into a variety of goods — including textiles, biofuels, food ingredients, polymers, pigments, and more domestically. This sustainable, scalable, and biological manufacturing process relies on microbes to convert sugars into high-value products.

“Our position as a regional leader in precision fermentation is solidified by this designation,” said iFAB partner Nicole Bateman, president of the Economic Development Corporation of Decatur & Macon County. “Receiving federal recognition unlocks opportunities for infrastructure development and business investment and attraction, which results in job creation. We have been partnering across the corridor informally for several years, and the momentum in the region will be enhanced by this formal designation.”  

As a designated Tech Hub, iFAB has cleared the first phase of the Tech Hubs program and qualifies to apply for phase two funding of $45 million to $70 million. EDA anticipates that between five and 10 of the 31 Tech Hubs will receive phase two funding. 

If successful, phase two funding would support several iFAB initiatives to expand the Central Illinois precision fermentation industry:  

“This historic announcement is a result of our regional and statewide collaboration and will enhance business attraction to our region, expanding our ever-growing AgTech footprint," said iFAB partner Carly McCrory-McKay, executive director of the Champaign County EDC. “We're thrilled about this Tech Hub designation for our communities and will work with our partners to ensure that the iFAB AgTech Corridor—made up of Champaign, Macon, and Piatt counties—becomes the global leader and innovation center in biomanufacturing. This is a game changer for innovation and economic growth, and we're proud to say that iFAB is a Tech Hub."

iFAB’s Tech Hub designation is a return on investment by the State of Illinois. “IBRL was a strategic experiment that has shown proof of concept,” Conerty said. “We have been overwhelmed by the response for equipment, infrastructure, and expertise. We are now bursting at the seams with a waitlist for equipment and processes. With more support, we could be doing so much more.” 

The consortium’s industry partners include ADM and Boston Bioprocess, who both have operations at Research Park, as well as Primient and Clarkson Grain Company

iFAB is one of two designated Tech Hubs in Illinois; the second is the Chicago-based The Bloch Tech Hub that focuses on quantum technologies. Both coalitions are part of Innovate Illinois, a strategic initiative led by Governor JB Pritzker to establish Tech Hubs in the state. 

“As one of America’s leading research universities, the University of Illinois Urbana-Champaign solves problems and helps to power our nation’s economy,” said U. of I. Chancellor Robert E. Jones. “These TechHub designations in Illinois unite our strengths with our academic, industrial, community, and government partners to imagine a bright future for communities across the region.” 

 

Older adults from distressed communities attend less cardiac rehab after heart procedures


Researchers say reducing barriers must be prioritized

Peer-Reviewed Publication

MICHIGAN MEDICINE - UNIVERSITY OF MICHIGAN




Older adults who live in disadvantaged communities are less likely to attend cardiac rehabilitation after common heart procedures, a Michigan Medicine-led study finds.

The study aimed to calculate how many Medicare beneficiaries attended cardiac rehabilitation, a medically supervised program exercise and education program, after coronary revascularization between mid-2016 and 2018.

Patient communities were categorized using the Distressed Community Index, which analyzes economic well-being and social determinants of health, such as educational disparities and poverty rate, of United States zip codes.

Only 26% of patients from distressed communities use cardiac rehab, compared to 46% of patients from areas deemed prosperous. Any patient who attended cardiac rehab, no matter where they lived, had a reduced risk of death, hospitalization and heart attack, according to results published in Circulation: Cardiovascular Quality and Outcomes.

“Addressing barriers to participation in cardiac rehabilitation in distressed communities may improve outcomes for these patients and reduce longstanding disparities in such outcomes,” said first author Michael P. Thompson, Ph.D., assistant professor of cardiac surgery at University of Michigan Medical School.

“While some individuals who face geographic barriers to participation may benefit from transportation services or virtual options for cardiac rehab, there is a critical need to address socioeconomic barriers that prevent so many patients from attending this lifesaving therapy.”

Additional authors include, Hechuan Hou, Francis D. Pagani, M.D., Ph.D., Robert B. Hawkins, M.D., Devraj Sukul, M.D., and Donald S. Likosky, Ph.D., all of University of Michigan, James W. Stewart II, M.D., of Yale School of Medicine, and Steven J. Keteyian, Ph.D., of Henry Ford Health.

This study was funded as part of a career development award Thompson received from the Agency for Healthcare Research and Quality (AHRQ, Grant no. 1K01HS027830).

Paper cited: “Relationship Between Community-Level Distress and Cardiac Rehabilitation Participation, Facility Access, and Clinical Outcomes After Inpatient Coronary Revascularization,” Circulation: Cardiovascular Quality and OutcomesDOI: 10.1161/CIRCOUTCOMES.123.010148

 

Home is where the high-quality resources are: nursery characteristics and territory distribution suggest reproductive resource defense in golden rocket frogs


For a species of tropical frog, researchers have recently discovered a surprising addition to things that adults find worth defending: suitable nurseries.


Peer-Reviewed Publication

UNIVERSITY OF JYVÄSKYLÄ - JYVÄSKYLÄN YLIOPISTO

Male golden rocket frogs 

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MALE GOLDEN ROCKET FROGS TRANSPORT THEIR TADPOLES “PIGGY BACK” AND CARE FOR THEM THROUGHOUT DEVELOPMENT, WHICH CAN LAST FOR MONTHS. 

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CREDIT: JAMES PAUL TUMULTY




Some things in life are worth fighting for - for animals the defense of space, known as territoriality, usually functions to safeguard valuable resources like food and mates. However, for a species of tropical frog, researchers have recently discovered a surprising addition to things that adults find worth defending: suitable nurseries.

Human parents are well aware of the lengths some will go to to secure a first-rate nursery school for their children. Oddly enough, a parallel can be found next to the world’s tallest single-drop waterfall (Kaieteur Falls, Guyana) home to a population of small golden-colored frogs. These small poison frogs spend their entire lives in enormous plants called giant tank bromeliads: within these plants, eggs are laid in the lower leaves and hatch as tadpoles. Fathers then transport their young to pools higher in the plant through an elaborate piggyback ritual where tadpoles cling to a father’s back. The tadpoles must survive in selected leaf axils until metamorphosis, meaning the quality of a nursery can have profound implications for the success of the tadpoles contained within them.

- Of course, if a frog’s only suitable breeding-ground is on top of an isolated waterfall in the middle of the Guyanian Amazon, it isn’t surprising that there isn’t room for everyone. Thus, in addition to their intense parental care duties, male rocket frogs are extremely territorial and aggressively defend established areas in bromeliads (which consist of multiple leaves) from potential intruders, clarifies researcher Chloé Fouilloux from University of Jyväskylä, Finland.

Male poison frogs defend territories

Researchers Chloé Fouilloux (University of Jyväskylä, Finland), Johana Goyes Vallejos (University of Missouri), and James Tumulty (College of William and Mary) wondered if the intense territoriality of males had any relationship to their intensive care-giving duties. In their study, recently published in Evolutionary Ecology, the team first measured variation in bromeliad pools to understand what made nurseries desirable. One feature that stood out: the amount of mucilage, or “goop” as the researchers affectionately call it. Frog parents avoid this mucilaginous substance that fills nurseries and strongly decreases the amount of oxygen in the water. The team then mapped out male territories to see if the locations of these high-quality nurseries coincided with the territories. Indeed, these clear pools occurred more frequently within defended territories, suggesting males choose which plants to defend based on their characteristics.

- In other words, males defend areas that may benefit their reproductive output in the future-- perhaps a cognitive feat of future planning that is not typically associated with amphibians. In human terms, these parents are securing spots in Montessori schools before they were even pregnant, says Fouilloux.

Interested in learning more? This research was published in Evolutionary Ecology in October 2023.