Thursday, September 07, 2023

 

International report confirms record-high greenhouse gases, global sea levels in 2022


Peer-Reviewed Publication

AMERICAN METEOROLOGICAL SOCIETY

Selected Notable Climate Anomalies and Events in 2022 

IMAGE: WORLD MAP SHOWING LOCATIONS OF SIGNIFICANT CLIMATE ANOMALIES AND EVENTS IN 2022. view more 

CREDIT: NOAA




Greenhouse gas concentrations, global sea level and ocean heat content reached record highs in 2022, according to the 33rd annual State of the Climate report.

The international annual review of the world’s climate, led by scientists from NOAA’s National Centers for Environmental Information (NCEI) and published by the Bulletin of the American Meteorological Society (AMS), is based on contributions from more than 570 scientists in over 60 countries. It provides the most comprehensive update on Earth’s climate indicators, notable weather events and other data collected by environmental monitoring stations and instruments located on land, water ice and in space.

“This report is a truly international effort to more fully understand climate conditions around the globe and our capacity to observe them,” said NCEI Director Derek Arndt. “It is like an annual physical of the Earth system, and it serves present and future generations by documenting and sharing data that indicate increasingly extreme and changing conditions in our warming world.”

“People are causing the largest known change in global climate since our transition to agriculture thousands of years ago,” said Paul Higgins, associate executive director of the American Meteorological Society. “The State of the Climate in 2022 report—an ongoing collaboration between NOAA and AMS—helps us understand the climate system, the impact people are having on climate, and the potential consequences. The report can help inform the decisions needed to enable humanity and all life to thrive for generations to come.”

Notable findings from the international report include:

  • Earth’s greenhouse gas concentrations were the highest on record. Carbon dioxide, methane and nitrous oxide⁠—Earth’s major atmospheric greenhouse gases⁠—once again reached record high concentrations in 2022. The global annual average atmospheric carbon dioxide concentration was 417.1 parts per million (ppm). This was 50% greater than the pre-industrial level, 2.4 ppm greater than the 2021 amount, and the highest measured amount in the modern observational records as well as in paleoclimatic records dating back as far as 800,000 years. The annual atmospheric methane concentration also reached a record high, which was a 165% increase compared to its pre-industrial level and an increase of about 14 parts per billion (ppb) from 2021. The annual increase of 1.3 ppb for nitrous oxide in 2022, which was similar to the high growth rates in 2020 and 2021, was higher than the average increase during 2010–19 (1.0 ± 0.2 ppb), and suggests increased nitrous oxide emissions in recent years.
  • Warming trends continued across the globe. A range of scientific analyses indicate that the annual global surface temperature was 0.45 to 0.54 of a degree F (0.25 to 0.30 of a degree C) above the 1991–2020 average. This places 2022 among the six warmest years since records began in the mid to late 1800s. Even though the year ranked among the six warmest years on record, the presence of La Nina in the Pacific Ocean had a cooling effect on the 2022 global temperatures in comparison to years characterized by El Nino or neutral El Nino–Southern Oscillation (ENSO) conditions. Nonetheless, 2022 was the warmest La Nina year on record, surpassing the previous record set in 2021. With the re-emergence of El Nino in 2023, globally-averaged temperatures this year are expected to exceed those observed in 2022.All six major global temperature datasets used for analysis in the report agree that the last eight years (2015–22) were the eighth warmest on record. The annual global mean surface temperature has increased at an average rate of 0.14 to 0.16 of a degree F (0.08 to 0.09 of a degree C) per decade since 1880, and at a rate more than twice as high since 1981.
  • Ocean heat and global sea level were the highest on record. Over the past half-century, the oceans have stored more than 90% of the excess energy trapped in Earth’s system by greenhouse gases and other factors. The global ocean heat content, measured from the ocean’s surface to a depth of 2,000 meters (approximately 6,561 ft), continued to increase and reached new record highs in 2022. Global mean sea level was record high for the 11th-consecutive year, reaching about 101.2 mm (4.0 inches) above the 1993 average when satellite altimetry measurements began.
  • La Nina conditions moderated sea surface temperatures. La Nina conditions in the equatorial Pacific Ocean that began in mid-2020, with a short break in 2021, continued through all of 2022. The three consecutive years of La Nina conditions—an unusual “triple-dip”—had widespread effects on the ocean and climate in 2022. The mean annual global sea-surface temperature in 2022 equaled 2018 as sixth highest on record, but was lower than both 2019 and 2020 due in part to the long-lasting La Nina. Approximately 58% of the ocean surface experienced at least one marine heatwave in 2022, which is defined as sea-surface temperatures in the warmest 10% of all recorded data in a particular location for at least five days.
  • Heatwaves shattered temperature records across the planet. In July, a 14-day heatwave swept through western Europe. A weather station in England recorded a temperature of 104 degrees F (40 degrees C) for the first time ever, over 100 stations in France broke all-time temperature records, and stations in at least six other European countries set all-time heat records. The extreme high summer temperatures over Europe resulted in unprecedented melting of glaciers in the Alps, with over 6% of their volume—a record loss—lost in Switzerland in 2022 alone. Record-breaking summer heat in central and eastern Asia, particularly in the Yangtze River basin, led to a devastating drought that affected more than 38 million people and caused a direct economic loss of $4.75 billion U.S. dollars.
  • The Arctic was warm and wet. The Arctic had its fifth-warmest year in the 123-year record. 2022 marked the ninth-consecutive year that Arctic temperature anomalies were higher than the global mean anomalies, providing more evidence of the process known as Arctic amplification in which physical processes cause the Arctic to warm more quickly than the rest of the planet. The seasonal Arctic minimum sea-ice extent, typically reached in September, was the 11th-smallest in the 43-year record. The amount of multiyear ice—ice that survives at least one summer melt season—remaining in the Arctic continued to decline. Since 2012, the Arctic has been nearly devoid of ice that is more than four years old. Annual average Arctic precipitation for 2022 was the third-highest total since 1950, and three seasons (winter, summer and autumn) ranked among the 10 wettest for their respective season. 
  • Although tropical cyclone activity was near average, storms brought devastation to many areas across the globe. There were 85 named tropical storms during the Northern and Southern Hemisphere storm seasons last year, which was near the 1991–2020 average of 87. Three tropical cyclones reached Category 5 intensity on the Saffir–Simpson Hurricane Wind Scale, which was the fewest Category 5 storms globally since 2017. The accumulated cyclone energy for the globe was the lowest since reliable records began in 1981. Despite this, several storms caused massive damage. In the North Atlantic, Hurricane Fiona became the most intense and most destructive tropical or post-tropical cyclone in Atlantic Canada’s history. Hurricane Ian, a major hurricane, killed more than 100 people and became the third costliest disaster in the United States, with damage estimated at $113 billion U.S. dollars. In the South Indian Ocean, Tropical Cyclone Batsirai dropped 2,044 mm of rain at Commerson Crater in Réunion. The storm also led to 121 fatalities in Madagascar.

The State of the Climate report is a peer-reviewed series published annually as a special supplement to the Bulletin of the American Meteorological Society. The journal makes the full report openly available online. NCEI’s high-level overview report is also available online.

 

Patients with AML who received vitamin C/D supplements had fewer complications, but no overall survival benefit seen


Subgroup analysis finds survival advantage for patients with NPM1 mutation

Peer-Reviewed Publication

AMERICAN SOCIETY OF HEMATOLOGY



Patients with acute myeloid leukemia (AML) who received vitamin C and D supplements while undergoing intensive chemotherapy had lower rates of complications, such as infections, bleeding, and inflammation, when compared with similar, previously treated patients who did not receive these supplements. Moreover, while the study showed no difference in survival between the two groups, a subgroup analysis showed that among patients with a genetic mutation known as NPM1 – found in about one in three patients with AML – the risk of death was nearly 50% lower among those who were taking the supplements. The results published today in the journal Blood Advances.

“To the best of our knowledge, this is the first study to examine the potential effects of vitamin C and D supplementation during intensive chemotherapy for AML,” said Christian Récher, MD, of the University Cancer Institute of Toulouse in France and the study’s senior author. “We have shown that supplementation is feasible and safe and may help reduce some significant adverse events associated with intensive chemotherapy, which is a clear benefit for patients.”

Dr. Récher and his colleagues began treating all adult patients with AML undergoing intensive chemotherapy with vitamin C and D supplements, based on the findings of several previous studies. One of these studies suggested that higher vitamin D levels prior to a donor stem cell transplant reduced the risk of a post-transplant relapse in patients with AML, while two laboratory studies indicated that vitamin C supplementation could suppress the development of leukemic cells.

In this study, the researchers compared outcomes for 431 patients with AML who received intensive chemotherapy at the University Cancer Institute of Toulouse over a five-year period; 169 patients, treated between 2018 and 2020, received vitamin C and D supplements while 262, treated between 2015 and 2018 (the control group), did not. ADD statement/info on response potentially including reduced side effects.

The median age of patients in the supplementation group was 65 and 52% were women, while in the control group, the median age was 60 and 53% were men. At the time of their AML diagnosis, most patients in both groups had low levels of vitamins C and D. Roughly a quarter of patients in the supplementation group and a third of those in the control group went on to receive donor stem cell transplants. The median follow-up period was 28.7 months for the supplementation group and 58.2 months for the control group.

In the supplementation group, vitamin D levels increased significantly from 18 ng/mL at diagnosis to 39 ng/mL at recovery from intensive chemotherapy. The normal range for vitamin D is between 20 and 50 ng/mL No significant increase was seen in vitamin C levels likely due to a conservative regimen (6 grams per week).

During intensive chemotherapy, patients receiving the supplementation experienced lower rates of moderate to severe bacterial infections (27.2% versus 35.1% in the control), bleeding (1.8% versus 5.7% in the control), and potentially life-threatening inflammation of the immune system (1.8% versus 8.8% in the control). Median overall survival was 34.5 months, median survival without a relapse was 20.6 months, and the cumulative incidence of relapse was 46.4%. No significant differences between the two groups were observed when the researchers analyzed outcomes for all treated patients combined.

However, a subgroup analysis found that patients in the supplementation group with an NPM1 mutation – the most common mutation found in 30% to 35% of patients with AML – had a 48% reduced risk of death compared with patients who did not have the mutation. Further studies are needed to identify the mechanism responsible for this survival difference, Dr. Récher said.

Dr. Récher and his team were especially surprised by the improved survival in patients with an NPM1 mutation who received the supplements but cautioned that this association requires confirmation in a larger, randomized study. 

The study has several limitations. It was a retrospective study conducted at a single institution that compared outcomes for patients treated before and after the institution introduced supplementation for all adult patients undergoing intensive chemotherapy for AML. The study also involved a relatively small number of patients. Additionally, because all patients in the supplementation group received both vitamin C and vitamin D, the researchers could not analyze the independent effect of each vitamin or the value of combining them.

Despite these limitations, Dr. Récher said, “Our results are encouraging and support prospective clinical trials of vitamin C and D administration in AML patients.”

As always, patients should review with their care teams the medications they take, including any over-the-counter medications, vitamin and dietary supplements, and ask before starting specific supplements.

# # #

Blood Advances (www.bloodadvances.org) publishes more peer-reviewed hematology research than any other academic journal worldwide and is an online only, open access journal of the American Society of Hematology (ASH), the world’s largest professional society concerned with the causes and treatment of blood disorders.

Blood Advances® is a registered trademark of the American Society of Hematology.

Contact:

Kira Sampson, American Society of Hematology

ksampson@hematology.org; 202-499-1796

 FOSSILS

New koala relative fills a branch of Australia’s unique marsupial story


Peer-Reviewed Publication

FLINDERS UNIVERSITY

molars 

IMAGE: COMPARISON OF UPPER MOLAR MORPHOLOGY BETWEEN CHULPASIA JIMTHORSELLI, LUMAKOALA BLACKAE AND THE MODERN KOALA. view more 

CREDIT: A CRICHTON (FLINDERS UNIVERSITY)




Koalas are endangered in much of Australia now but in in the past there were multiple species living across the continent. The discovery of an ancient relative of the koala helps fill a 30 million year gap in the amazing evolution of Australia’s marsupials, according to a new study by Australian and British scientists published in Scientific Reports

The study was led by Flinders University PhD student Arthur Crichton, who found fossil teeth of the new species at the Pwerte Marnte Marnte fossil site south of Alice Springs, thought to be about 25 million years old.  

“The new species, which has been named Lumakoala blackae, weighed roughly 2.5 kg (about the size of a modern day brushtail possum, or a small domestic cat), and probably ate mostly soft leaves, but wouldn’t have turned down an insect given the chance,” says Mr Crichton, who analysed field samples collected in 2014 and 2020. 

“Our computer analysis of its evolutionary relationships indicates that Lumakoala is a member of the koala family (Phascolarctidae) or a close relative, but it also resembles several much older fossil marsupials called Thylacotinga and Chulpasia from the 55 million-year-old Tingamarra site in northeastern Australia.  

“In the past, it was suggested the enigmatic Thylacotinga and Chulpasia may have been closely related to marsupials from South America.  

“However, the discovery of Lumakoala suggests that Thylacotinga and Chulpasia could actually be early relatives of Australian herbivorous marsupials such as koalas, wombats, kangaroos and possums.” 

“This group (Diprotodontia)is extremely diverse today, but nothing is known about the first half of their evolution due to a long gap in the fossil record.” 

“If our hypothesis is correct, it would extend the diprotodontian fossil record back by 30 million years. We would really expect early diprotodontians to have been around at the time; molecular information suggests koalas, wombats, kangaroos and possums split off from other marsupials between about 65 million and 50 million years ago.”   

Co-author Associate Professor Robin Beck, from England’s University of Salford, says the discovery of Lumakoala helps fill a major 30 million-year-old gap in Australian marsupial evolution. 

“These Tingamarran marsupials are less mysterious than we thought, and now appear to be ancient relatives of younger, more familiar groups like koalas,” says Dr Beck.  

“It shows how finding new fossils like Lumakoala, even if only a few teeth, can revolutionise our understanding of the history of life on Earth.” 

The study raises important new questions, including whether these relatives of Australian herbivorous marsupials once lived in South America and Antarctica, Dr Beck says, adding there are South American fossils that look very similar to the Tingamarran marsupials.  

The new study also reports the presence of two other types of koala – Madakoala and Nimiokoala – that lived alongside Lumakoala, filling different niches in the central Australian forests that flourished 25 million years ago.  

Professor Gavin Prideaux, director of the Flinders University Palaeontology Laboratory, describes the late Oligocene (23–25 million years ago) as a “kind of the koala heyday”.  

“Until now, there’s been no record of koalas ever being in the Northern Territory; now there are three different species from a single fossil site,” says Professor Prideaux. 

“While we have only one koala species today, we now know there were at least seven from the late Oligocene – along with giant koala-like marsupials called ilariids.  

Iliariids were the largest marsupials in Australia at the time, weighing in at up to 200 kg. They lived alongside a strong-toothed wombat relative named Mukupirna fortidentata and bizarre possum, Chunia pledgei.

The article, A probable koala from the Oligocene of central Australia provides insights into early Diprotodontia evolution (2023) ) by Arthur I Crichton, Robin MD Beck, Aidan MC Couzens, Trevor H Worthy, Aaron B Camens and Gavin J Prideaux has been published in Scientific Reports. DOI: 10.1038/s41598-023-41471-0. 

Photos, map and graphics at the link: Reconstruction illustration by Peter Schouten

https://onedrive.live.com/view.aspx?resid=2D5755806FD48E50!86300&cid=2d5755806fd48e50&authkey=!ALLHScFGz3u4qK4&CT=1693887499272&OR=ItemsView 

Reconstruction of the 25 million year old Ditjimanka Lumakoala blackae, featuring (left to right) the wallaby-sized herbivore Muramura williamsi, extinct koala relative Madakoala devisi and the calf-sized ilariid (Ilaria lawsone). Courtesy of Peter Schouten

CREDIT

Illustration courtesy of Peter Schouten

Flinders University palaeontology researcher Arthur Crichton, who found fossil teeth of the new species at the Pwerte Marnte Marnte fossil site south of Alice Springs, thought to be about 25 million years old.

CREDIT

Flinders University

WOMYN'S HEALTH

Review of over 70 years of menopause science highlights research gaps and calls for individualized treatment


Peer-Reviewed Publication

CELL PRESS

Menopause symptoms and long-term consequences 

IMAGE: CARDINAL SYMPTOMS AND CONSEQUENCES OF MENOPAUSE view more 

CREDIT: CELL, DAVIS ET AL.




Although about half of people go through menopause, less than 15% of them receive effective treatment for their symptoms. Treatment options for people experiencing irritating or severe menopause symptoms are often under researched, and some have questionable efficacy, or cause harmful side effects. In a comprehensive review publishing in the journal Cell on September 6, a team of world-renowned menopause experts summarizes what we know about menopause, calls for more research into the timeline and treatment of menopause, and encourages individualized, holistic treatment that addresses both menopausal symptoms and other systemic changes happening in the body.

“The road to menopause is not difficult for all, but for some, symptoms may be severe or even disabling and disruptive to work and family,” write the authors, who are based in Australia, Italy, and the United States. “Recognition that menopause, for most women, is a natural biological event, does not exempt the use of interventions to alleviate symptoms.”

For this review, the researchers looked at over 200 sources across 71 years to synthesize what’s currently known about menopause. The authors note the importance of recognizing that menopause impacts more than just cis women; they elect to use the term “women” in this review to reflect the language and focus of much of the research that currently exists in the field.

Key takeaways from the review include the following:

  • The authors propose a new definition for menopause as “final cessation of ovarian function,” an update to the traditional definition, which focused on menstruation. While the new definition doesn’t account for all variability, it seeks to encompass people of all genders, as well as people who have irregular periods, use certain types of contraception like IUDs, have had hysterectomies, and more.
  • The timeline of when menopause phases occur isn’t well understood and varies from person to person, so the authors argue that current age restrictions on prescriptions and therapies are illogical and problematic. While symptoms often start during perimenopause, few menopause therapies are currently approved for perimenopausal patients.
  • Menopause treatments range from hormone therapies to lasers to plant products, but the authors argue that few have been studied over long enough timespans. They highlight potential side effects and health concerns for each type of treatment and note that even the most effective and well-researched option available presently—hormone therapy targeting estrogen—is still far from a perfect solution for all.
  • Symptoms vary widely between people and throughout the course of menopause. Some people get many severe symptoms while others get few to none; but even if someone has no noticeable symptoms, there can still be significant “silent health consequences,” including bone loss and a higher risk of diabetes, cardiovascular diseases, and certain types of cancers. Additionally, the authors highlight that some symptoms, like short-term memory loss, can be temporary, and note that other symptoms, like depression and anxiety, are sometimes pre-existing conditions that have been falsely attributed to menopause due to stigma surrounding it. They also recommend exercising regularly and maintaining a nutritious diet that includes plenty of protein as a way to reduce the likelihood of contracting symptomatic health complications.
  • The authors highlight the fact that socio-economic factors such as lower quality of life and the potential negative impact of menopausal symptoms on a woman’s work performance aren't often acknowledged.

“Despite decades of research pertaining to menopause, more work is needed,” write the researchers. Going forward, they call researchers to look deeper into when the menopause process starts and to focus on making menopause treatments more effective and safer overall. They underline the importance of researching the symptoms and other health impacts of menopause outside of high-income countries. Additionally, they suggest studying the impacts of menopause on work both from home and in an office, as well as the impacts on people with less traditional career paths such as caregivers and volunteers.

The team also argues that menopause treatments need to be holistic and tailored to the person being treated—addressing both the physical and mental health impacts of menopause, as well as the underlying health risks associated with menopause and any other relevant health concerns. “Women with bothersome menopausal symptoms should be counseled on treatment options and offered evidence-based therapies,” they write. “Therapy should be individualized depending on age and health risks, recognizing that health risks may increase with age.”

“Optimizing health at menopause is the gateway to healthy aging for women,” write the authors.

###

Cell, Davis et al. “Menopause – Biology, Consequences, Supportive Care and Therapeutic Options.” https://www.cell.com/cell/fulltext/S0092-8674(23)00905-4 DOI: 10.1016/j.cell.2023.08.016

Cell (@CellCellPress), the flagship journal of Cell Press, is a bimonthly journal that publishes findings of unusual significance in any area of experimental biology, including but not limited to cell biology, molecular biology, neuroscience, immunology, virology and microbiology, cancer, human genetics, systems biology, signaling, and disease mechanisms and therapeutics. Visit: http://www.cell.com/cell. To receive Cell Press media alerts, contact press@cell.com.