Sunday, August 04, 2024

 

Oropouche virus: More questions than answers



Compuscript Ltd






https://www.scienceopen.com/hosted-document?doi=10.15212/ZOONOSES-2024-0006

Announcing a new article publication for Zoonoses journal. Oropouche virus (genus Orthobunyavirus, family Peribunyaviridae) is an arthropod-borne virus that infects several species of animals and humans, primarily in South America. Despite being described as a human pathogen >60 years ago, little progress has been made towards describing the ecologic and pathologic characteristics of this pathogen. However, with recent viral spread northward reaching Haiti and Cuba, oropouche virus has been receiving more attention, as evidenced by the growing number of relevant research articles.

This commentary article provides a summary of the potential natural reservoirs and expansion of endemic regions within the context of One Health. The clinical aspects of the human infection are revisited and discussed based on the latest evidence. Moreover, research on the molecular virology and pathology is briefly reviewed, highlighting unanswered questions crucial for a comprehensive understanding of this viral disease, which imposes a significant burden on affected populations.

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Zoonoses is fully open access journal for research scientists, physicians, veterinarians, and public health professionals working on diverse disciplinaries of zoonotic diseases. Please visit https://zoonoses-journal.org/ to learn more about the journal.

 

Zoonoses is now open for submissions; articles can be submitted online at https://mc04.manuscriptcentral.com/zoonoses

There are no author submission or article processing fees.

 

Editorial Board: https://zoonoses-journal.org/index.php/editorial-board/

 

Zoonoses is available on ScienceOpen (https://www.scienceopen.com/search#collection/839df240-327f-47dd-b636-9b728dff9700).

 

Follow Zoonoses on Twitter @ZoonosesJFacebook (https://www.facebook.com/Zoonoses-Journal-100462755574114 ) and LinkedIn (https://www.linkedin.com/company/zoonoses/)

 

eISSN 2737-7474

ISSN 2737-7466

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Eduardo Jurado-Cobena. Oropouche Virus: More Questions than Answers. Zoonoses. 2024. Vol. 4(1). DOI: 10.15212/ZOONOSES-2024-0006

What role have states played in the legalization of medical marijuana?



Penn State





HARRISBURG, Pa. — From the war on drugs to the current wave of legalization efforts, public opinion in the United States has shifted on few issues like it has with marijuana. How and why have attitudes and policies changed so drastically and rapidly?

That’s the question posed by Daniel Mallinson, associate professor of public policy and administration at Penn State Harrisburg, and Lee Hannah, professor of political science at Wright State University, in their new book, “Green Rush: The Rise of Medical Marijuana in the United States.”

“While there are a lot of good books on the topic, we didn't think anyone had centered the states as the main locus of innovation and experimentation,” Hannah said.

The use, sale and possession of marijuana is prohibited by federal law. Yet, currently, 38 states and the District of Columbia has legalized the medical use of marijuana while 24 states and D.C. have legalized marijuana for recreational use.

Mallinson and Hannah, state politics scholars who met as doctoral students at Penn State, wanted to tell a comprehensive story about medical marijuana. In their book, the authors examine the history of cannabis legalization, how medical marijuana programs started to get passed in the states, how states like Pennsylvania, Ohio and West Virginia have implemented their legalization efforts and how state policy initiatives have influenced conversations on the national level.

“You cannot understand marijuana policy in the United States, and really the changes in drug policy more broadly, without studying what’s happening at the state level,” Mallinson said.

Penn State News spoke with Mallinson about the book, the rise of medical marijuana in America and the role Pennsylvania has played.

Q: Let’s start with some basic definitions. What is considered medical use of marijuana?

Mallinson: We focus on what we call comprehensive medical marijuana laws where there’s legal protection from state prosecution for possession and use and there’s access to product, such as through dispensaries or home grown. There are usually regulations on the industry too, like packaging and advertising regulations and tracking.

States design their programs differently. More conservative states, including Pennsylvania, adopted programs that are more structured and have more regulations and restrictions. In Pennsylvania, you must have a condition that’s on the list of conditions approved for medical cannabis and you have to go to a registered physician. Other states, like California, have looser regulations.

Q: How has the public perception of medical marijuana has changed over the years?

Mallinson: The percentage of Americans who think marijuana should be legalized has increased from 12% in 1969 to nearly 70% today. That’s a huge change and, like same sex marriage, it’s one of those issues where you see a large change in public opinion very quickly.

In the book, we talk about the image of the user and how medical use of marijuana is in some ways an easier sell. Initially, it’s the cancer patient, AIDS patient and glaucoma patient.

Then, after the war on terror era, veterans start to push for legalization for medical use for things like post-traumatic stress disorder and chronic pain. Groups of moms whose kids have severe epilepsy diseases — marijuana proves pretty efficacious in reducing seizures — who also advocate for legalization. These groups, which are broadly viewed more positively, helped push the issue into more conservative states.

Q: What were the key considerations in passing Pennsylvania’s medical marijuana law?

Mallinson: Pennsylvania has an interesting history. Medical marijuana legislation was introduced by the Democrats in the Republican-controlled state Senate in the early 2010s, but it wasn’t going anywhere until Republican state Senator Mike Folmer got involved.

He said he was swayed by a group of moms who came and talked to him about medical marijuana and the benefits for their kids. Folmer also had cancer and, at the time, people didn’t know that he had used cannabis during treatment. That was revealed later, though he maintained that wasn’t his motivation for championing medical marijuana. This also coincides with increasing opioid overdoses in the state which, combined with increasing conversation about whether cannabis could be a substitute for opioids, also helped push medical marijuana forward.

It was an uphill battle, but Folmer was well-respected and medical marijuana passed in the state Senate. It eventually passed in the House, which also had a Republican majority, and was signed into law in 2016 by Governor Tom Wolf. Getting Republicans on board in a state like Pennsylvania was important and you see that happening now with recreational marijuana legislation, which has Republican co-sponsors.

Q: You’ve mentioned that what happens on the state level affects what's happens on the national level. What role has Pennsylvania played in this larger national conversation around medical marijuana policies?

Mallinson: We have a strong supporter of legalizing cannabis for adult use in Pennsylvania’s Senator John Fetterman. He was credited with moving Wolf on the issue, who wasn’t very supportive early on, and he’s taken that to the Senate.

Pennsylvania was also one of the first states to adopt a social equity component in its medical marijuana law, which has become a cornerstone issue in the legalization of marijuana for recreational use and a major sticking point in Congress as they’re working on cannabis legislation.

Prior to legalization, you could go to jail for possession and young people of color were disproportionately affected. What happens now that it’s legal and there are rules that say you can’t be involved in the industry if you have a prior marijuana conviction? Social equity programs aim to address the inequities so that people can participate. They can also work to repair harms to communities affected by the war on drugs.

Q: Where do we go from here, both on a state and federal level?

Mallinson: On the state level, the conversation around adult-use recreational marijuana has ramped up. It has Republican co-sponsors in both chambers and Governor Josh Shapiro is open to it. It’s a big shift and there seems to be decent momentum. How long will it take? I don’t know.

On the federal level, the Department of Justice has proposed rescheduling marijuana, which would ease restrictions. It’s a big departure from past federal policy but wouldn’t legalize it or make the state programs legal. But there are still a lot of open questions and rescheduling does not solve all of the problems with state-legal marijuana. Is it inevitable that the federal government will legalize or totally decriminalize marijuana? Maybe? But Lee and I are very cautious about how fast the federal government will do anything.

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news relea

 

Big sharks have a big impact — and a big problem



Apex species like tiger sharks and great whites play an oversized role in their ecosystems, but are also the hardest hit by fishing



Peer-Reviewed Publication

University of California - Santa Barbara

Blue Shark 

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Apex predators like this blue shark have an outsized influence on their ecosystems. Unfortunately, they’re also the hardest hit by fishing.

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Credit: Neil Ferdinand Nathan




(Santa Barbara, Calif.) — The ocean has hammerheads, sawsharks and even spadenose sharks. It seems there’s a shark for every task. Indeed, these predators each have specific roles to play in their ecosystems. A healthy ocean requires sharks of different shapes and sizes.

Unfortunately, sharks’ diverse contributions are under threat from overfishing, climate change, habitat loss, coastal development, shipping activities and more. That’s why an international team of scientists contend that shark conservation must go beyond simply protecting shark populations — it must prioritize protecting the ecological roles that sharks fill. These findings come from a study published in Science that sheds new light on the role sharks play in healthy oceans, and why size should be a factor in conservation decisions.

The largest individuals of apex species like tiger sharks and great whites play an oversized role in healthy oceans. But they are often the most affected by fishing. Big sharks help maintain balance through their eating habits. Sometimes their sheer size is enough to scare away prey that could over-consume seagrass and other plant life needed for healthy oceans.

“Despite the fact the sharks are well recognized and appreciated in popular media and lore, their importance in maintaining ecosystem health was understudied and underappreciated,” said co-author Jennifer Caselle, a marine biologist at UC Santa Barbara. “We show that sharks are critical components to ecosystem function, making their global population declines particularly worrisome. Conservation measures to protect sharks are urgently needed.”

Besides playing critically important roles within the food web, reef sharks feed in offshore waters and bring nutrients back to the reef. Others move around nutrients that are used at the base of the food chain. Sharks can also serve as food for other species and even as scratching posts for fish to remove parasites. The problem is that shark abundance, for oceanic species, has plummeted by 71% in the past 50 years. Populations of the top five reef shark species have declined by 63%. As their numbers nosedive, their important roles in ocean health are also lost.

“It’s time to have a conversation about everything sharks are doing to maintain ocean health so we can better prioritize conservation efforts and have the biggest impact,” said lead author Simon Dedman, a researcher at Florida International University, which led the study team.

The researchers built upon a variety of datasets and previous studies to estimate global shark population trends. For instance, former UCSB doctoral student Erin Dillon discovered that she could use fossil shark scales excavated during digs in prehistoric reefs in the Caribbean to estimate the region’s shark populations. The shape and prevalence of different shark scales enabled her to estimate the type and abundance of sharks going back almost 6,000 years. By comparing data from multiple sites in this new report, she was able to document that shark abundance in the region declined by approximately 70% since prehistoric times.

Fortunately, it is not bad news for all sharks. There are a few promising instances where smart and responsible management appears to be helping sharks — and the jobs they perform in nature — to recover. Co-author and UCSB professor Douglas McCauley, who studies white sharks in Santa Barbara using drones and AI, cites their situation as a hopeful example. In addition to laying out a roadmap to see more such shark success stories, this new research also provides advice on how we can share our ocean backyards with sharks. “We’ve learned a lot about how to co-exist with ecologically important species that we’ve brought back on land, like bears and wolves, that can help us better share space with these recovering ocean wildlife,” he said.

The issue of shark conservation becomes all the more critical as global temperatures increase, leading some sharks to head into new areas where they can find the temperatures they can thrive in.

“This study verifies what we’ve long suspected – sharks are critical to ocean health,” said Lee Crockett, executive director of the Shark Conservation Fund, which funded the study. “This landmark study serves as confirmation that marine conservationists, philanthropists, policymakers and the public alike need to recognize that sharks are keystone species that have a now-proven significant effect on marine environments.”

With the expansion of blue economy industries like aquaculture and tourism, people’s encounters with sharks will likely increase. Finding a balance that protects the sharks most needed for healthy oceans is hitting a critical point.

“National and international policy must focus on actions that rebuild populations and restore sharks' functional roles,” said Mike Heithaus, study co-author and FIU marine ecologist. “That requires action to increase both spatial measures like marine protected areas and fisheries management measures like catch/size limits and gear limitations. If people want healthy oceans, we need healthy shark populations.”


Predation pressure affects how far herbivorous fish will feed from reefs. These ‘halos’ are larger when apex predators keep smaller predators in check, decrease when smaller sharks proliferate, and grow again when these sharks decline. Without any sharks, the entire area gets mowed bare.

Credit

Dedman & Moxley et al.

Breakthrough in plant disease: New enzyme could lead to anti-bacterial pesticides


Researchers uncover the crucial role of OpgD enzyme in enhancing Xanthomonas pathogenicity




Tokyo University of Science

Conversion of linear β-1,2-glucan to cyclic compound 

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Scientists identified the cyclic compound as CβG16α.

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Credit: Masahiro Nakajima from Tokyo University of Science



Plant diseases pose significant challenges to agricultural productivity, presenting formidable hurdles that require urgent attention. Left unchecked, these diseases can spread rapidly, inflicting widespread damage on crops and leading to reduced yields and substantial economic losses. Therefore, accurately identifying the pathogens responsible for these diseases is crucial. This identification allows for targeted interventions that minimize risks and effectively mitigate the agricultural impacts.

Xanthomonas species are notorious plant pathogens that affect a broad spectrum of hosts, including key crops like rice, wheat, and tomatoes. These pathogens augment their pathogenicity by utilizing α-1,6-cyclized β-1,2-glucohexadecaose (CβG16α) to suppress essential plant defense mechanisms, such as the expression of pathogenesis-related proteins and the accumulation of callose.

In a recent breakthrough published on June 19, 2024, in the Journal of the American Chemical Society, a team of researchers led by Associate Professor Masahiro Nakajima from Tokyo University of Science unveiled a significant discovery. They identified XccOpgD, a glycoside hydrolase (GH186) found in X. campestris pv campestris which plays a pivotal role in the biosynthesis of CβG16α. The research team also included Mr. Sei Motouchi from Tokyo University of Science, Principal Scientist Shiro Komba from the Institute of Food Research, NARO, and Hiroyuki Nakai from Niigata University.

“Glycan structures are intricate and multifaceted and fulfill diverse crucial roles in nature and organisms. Enzymes synthesize and degrade glycans, exhibiting diverse structures and functions that correspond to the glycan diversity. However, our understanding of these enzymes is still limited, which drives the search for new enzymes with varied new potentials,” explains Prof. Nakajima, elaborating on the study's rationale.

The team conducted biochemical analysis to elucidate the role of XccOpgD in CβG16α biosynthesis. Advanced techniques such as X-ray crystallography were employed as structural analysis to unravel the enzyme's catalytic mechanism and substrate specificity.

These efforts have yielded profound insights. XccOpgD belongs to the GH186 family, essential for regulating bacterial cell wall components. Unlike the first identified GH186 enzymes, XccOpgD exhibits an unprecedented enzymatic mechanism known as anomer-inverting transglycosylation.

“Reactions of typical GH enzymes are classified into four types by combination of retaining or inverting, and reaction with water (hydrolysis) or sugar (transglycosylation) theoretically. However, one classification is missing somehow in a long history of researches on carbohydrate associated enzymes and we discovered the missing classification. This breakthrough was made possible by unique structural environment, opening new possibilities for enzyme-based glycosylation,” explains Prof. Nakajima. Moreover, the sugar chains synthesized through this mechanism are not merely minor components but rather essential structures utilized by various Gram-negative bacteria in nature for pathogenic purposes.

Detailed studies revealed that linear β-1,2-glucan was converted to cyclic compound and the compound was identified as CβG16α using nuclear magnetic resonance. Structural analysis of the Michaelis complex identified crucial substrate binding residues, further elucidating specific interactions along the glucan chain. Notably, XccOpgD utilizes an anomer-inverting transglycosylation mechanism, with D379 and D291 playing pivotal roles as catalysts.

These findings deepen our understanding and open avenues for developing targeted strategies against Xanthomonas-induced plant diseases. “We are expecting a pesticide concept targeting this enzyme homolog in the future. Unlike fungicides that promote the emergence of drug-resistant bacteria in soil, targeting this enzyme could potentially inhibit pathogenicity without causing sterilization. Enzyme homologs identified in this study may serve as promising structure-based drug targets, offering a potential solution to the issue of drug-resistant bacteria,” says a hopeful Prof. Nakajima.

The discovery of XccOpgD and its role in CβG16α biosynthesis marks a major breakthrough in agriculture. It promises enhanced resilience and food security while mitigating environmental impacts linked to conventional pesticides. Overall, this advancement offers sustainable solutions to global agricultural challenges, promoting environmental stewardship and economic viability for farmers worldwide.

 

Unveiling XccOpgD: Key Player in Plant Pathogen Defense 

***

 

Reference

DOI: 10.1021/jacs.4c02579

 

Authors: Sei Motouchi1, Shiro Komba2, Hiroyuki Nakai3, and Masahiro Nakajima1

 

Affiliations:        

1Department of Applied Biological Science, Tokyo University of Science  

2Institute of Food Research, National Agriculture and Food Research Organization

3Faculty of Agriculture, Niigata University

 

Funding information
This work was supported in part by JST SPRING (Grant 386 Number JPMJSP2151).

New research sheds light on relationships between plants and insects in forest ecosystems


USDA Forest Service - Pacific Southwest Research Station
Seana Walsh from the National Botanical Garden in Kauaʻi collects leaf litter at Kokeʻe State Park in Kauaʻi. 

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Seana Walsh from the National Botanical Garden in Kauaʻi collects leaf litter at Kokeʻe State Park in Kauaʻi. 

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Credit: Photo by Nina Ronsted




U.S. Forest Service researchers and partners published new findings on how leaf-eating insects affect forest ecosystems worldwide.

“The findings of this study provide an improved understanding of the intricate relationship between herbivorous insects and forest ecosystems,” Bernice Hwang, the paper’s lead author and former U.S. Forest Service technician, stated.

Hwang and fellow researchers are aware of how large herbivores cycle nutrients in forests. They know much less, however, about how leaf-eating insects impact forest carbon and nutrient cycling. And they were determined to find out.

Their first step was establishing a global network of 74 plots within 40 mature, undisturbed broadleaved forests. They analyzed leaf litter and green leaves for carbon, nitrogen, phosphorus and silica concentrations. Leaf production, how much insects feed on leaves, and fluxes in nutrient levels from other sources also informed their research.

Chistian Giardina and Nels Johnson of the Pacific Southwest Research Station and other researchers found that insects play a significant role in releasing and cycling vital nutrients in forest ecosystems. This was particularly true for warmer climates like those in tropical forests.

Their findings suggest that a warming climate can affect how plants and herbivores interact. Changes in those relationships have important consequences for carbon and nutrient cycling in broadleaved forests on a global scale.

The researchers hope this new knowledge can contribute to a better understanding of forest ecosystems and inform efforts to conserve them.

“I believe this analysis will be a benchmark to compare against for its field,” Johnson noted.

Feeling judged by your doctor? You might be right



Patients who share inaccurate beliefs with their medical team are viewed more harshly by those healthcare professionals, Stevens study shows



Stevens Institute of Technology

Stevens Campus 

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Stevens Campus

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Credit: Stevens Institute of Technology






When an individual visits their doctor, they aren’t supposed to keep secrets. Unless patients are forthcoming about their symptoms, behaviors, and health-related beliefs, it’s hard for healthcare professionals to effectively diagnose and treat illnesses—or to advise and educate patients about how to take better care of themselves in the future. 

There’s only one problem: new research from Stevens Institute of Technology shows that many people believe they may be judged if they share mistaken beliefs with their care team—and that doctors really do take strongly negative views of patients who disclose incorrect or unreasonable beliefs.

“People worry about their doctors looking down on them—and it turns out that’s an entirely rational concern,” says Dr. Samantha Kleinberg, the lead researcher on the project. “Our study suggests that doctors really do judge patients harshly if they share information or beliefs that they disagree with.”  

To understand how people think about sharing information with healthcare professionals, Dr. Kleinberg and her collaborators surveyed over 350 patients and over 200 physicians, asking how they would view people who held a range of different medical beliefs. Beliefs ranged from true information to incorrect statements of many types: some were reasonable (like believing that eating sugar causes diabetes); some were unreasonable (like believing that carrot juice cures diabetes); and some were conspiracy theories (like believing that pharmaceutical companies deliberately cause diabetes to create more customers for insulin). Dr. Onur Asan, also at Stevens Institute of Technology, co-authored the study along with Dr. Jessecae K. Marsh, a collaborator from Lehigh University. 

“The degree to which healthcare professionals held negative perceptions towards patients espousing misinformation surprised us, and suggests doctors may need additional support and resources to effectively treat such patients,” says Dr. Asan.  

The more unreasonable a person’s health beliefs, the more negatively they were viewed by both laypeople and healthcare professionals. “We found that our subjects viewed people negatively if they held mistaken beliefs—but viewed them much more negatively if they held more unreasonable or conspiratorial beliefs,” Dr. Kleinberg says. 

Surprisingly, however, there was little difference between the responses of doctors and laypeople or patients with personal experience. Even patients living with chronic health conditions, who were familiar with the complexities of healthcare, were highly intolerant of people who held mistaken beliefs, the team found. “We’d thought people who had diabetes themselves might be more sympathetic, but it wasn’t the case at all,” Dr. Kleinberg says. 

Physicians were also highly likely to view people negatively when they expressed mistaken beliefs about health-related topics. “That was a surprising result, and frankly a depressing one,” Dr. Kleinberg says. “Laypeople aren’t expected to have medical expertise, so doctors often have  to correct mistaken beliefs on health issues. That shouldn’t be something that leads doctors to view patients more negatively.” 

Surveys show that the majority of people hold at least some incorrect health-related beliefs, such as the false belief that taking vitamin C will cure their cold, or that eating a sugary snack can directly cause diabetes, making it all the more important that people feel free to solicit expert opinions. “We rely on our doctors to educate us and help us overcome these medical misconceptions—but that’s only possible if we’re able to express our ideas freely, without fear of being judged when we get things wrong,” Dr. Kleinberg says. 

Part of the problem is that it isn’t usually possible for laypeople to know whether their own beliefs are correct or incorrect, or whether they will be perceived as reasonable or unreasonable. That means patients are likely to withhold even true and reasonable beliefs in order to minimize the risk of being viewed negatively by their doctor.

More research is needed to explore the ways in which these negative perceptions impact real-world patient-doctor interactions, Dr. Kleinberg says. Still, she adds, it’s clear that physicians need to be doing more to make their patients feel safe and comfortable during routine interactions. 

“If we want to have clear communication between patients and healthcare professionals, we need to change the way that doctors think about patients who are misinformed,” Dr. Kleinberg says. “Doctors need to overcome their tendency to judge patients, and actively encourage patients to share their thoughts—even their incorrect ones—much more freely than they currently do.” 

About Stevens Institute of Technology

Stevens Institute of Technology is a premier, private research university situated in Hoboken, New Jersey. Since our founding in 1870, technological innovation has been the hallmark of Stevens’ education and research. Within the university’s three schools and one college, 8,000 undergraduate and graduate students collaborate closely with faculty in an interdisciplinary, student-centric, entrepreneurial environment. Academic and research programs spanning business, computing, engineering, the arts and other disciplines actively advance the frontiers of science and leverage technology to confront our most pressing global challenges. The university continues to be consistently ranked among the nation’s leaders in career services, post-graduation salaries of alumni and return on tuition investment.

 

 

Native Hawaiians face higher rates of accelerated biological aging, UH study finds



University of Hawaii at Manoa






We normally associate our age with the year we are born. However, what if your age could be better associated with other factors like health, diet, exercise, occupation and education level?

A new study by the University of Hawaiʻi at Mānoa discovered for the first time that Native Hawaiians experience higher accelerated biological aging in comparison to White and Japanese American residents. The study also reports that living in adverse environments, such as in neighborhoods with low socioeconomic status, is associated with accelerated biological aging independent of ethnic background. However, life experiences may be protective against accelerated aging.

“We observed that despite living in socioeconomically poorer neighborhoods, individuals who engaged in higher physical activity, had a higher level of education attainment, and healthier diets tended to have closer to normal biological aging, which was independently associated with lower BMI and lower risk for diabetes,” said lead author Alika Maunakea, a Native Hawaiian professor of epigenetics and health disparities researcher at the John A. Burns School of Medicine.

Cancer research data provides insight

To determine the findings, Maunakea and his team analyzed DNA samples from 376 participants in the UH Cancer Center’s ongoing multiethnic cohort. Biological aging refers to the gradual deterioration of cellular and physiological functions over time, reflecting the body’s true age at a molecular and cellular level, which may differ from chronological age. Biological aging is determined by studying a person’s DNA, but not the actual DNA sequence we know as genetics.

Known as “DNA methylation,” this epigenetic process controls gene activity and indicates biological age. Scientists can measure this in blood cells to determine if a person is aging faster or slower than their actual years. Faster biological aging is called age acceleration, which may correspond to health issues.

The association of life experiences with DNA methylation-derived biological age have mostly been studied in populations of European ancestry, with only a few studies on ethnically diverse populations. Yet, ethnically diverse populations suffer from diseases of health disparities, including Native Hawaiians who have a higher risk for and an earlier age of onset of diabetes, heart disease and certain cancers compared to all other major ethnic groups in the state of Hawaiʻi. Native Hawaiians also experience the highest all-cause mortality among all other ethnic groups. Maunakea hopes that this study sheds light on biological mechanisms that help to explain the origins of health disparities in Native Hawaiians in order to better address them.

“Results of this study have significant public health implications and can help shape health policy,” Maunakea said. “Certain neighborhood-level factors that influence your health, such as where you live and the environment built around you therein, can be hard to change. Yet individual-level lifestyle factors like education, physical activity and diet can be improved through federal, state, and community-based programs such as MAʻO Organic Farms in Waiʻanae, a region struggling with health and socioeconomic disparities.”

The results of the study are personal to Maunakea, having been born and raised in Waiʻanae.

“To me, the results are further proof that lifestyle matters to health and that as individuals we can do something about it,” Maunakea said. “Being Native Hawaiian doesn’t make us destined for disease, even if you live in poor neighborhoods. Our data at the molecular level shows clearly that engaging in healthier lifestyles reduces the risk for disease and likely improves longevity. This gives me hope that we can, in my lifetime, improve the overall health and wellbeing of our lāhui.”

This study was published in July 2024 in the Journal of the American Medical Association.

Future research

Maunakea said that more research is underway to determine whether different ethnic groups start off with different biological ages or whether the differences in biological ages observed are due to social inequities. A study on the socioecological determinants of pre-diabetes led by Maunakea that has completed the recruitment of more than 2,100 adult residents, mostly of Native Hawaiians and Pacific Islander ethnic background, is attempting to validate and expand on these findings.