Friday, December 04, 2020

Mexico City hospitals are filling up, but so are the streets

MEXICO CITY — Sometimes Latin American dance tunes on the radio — salsa, cumbia, ranchera — bring a little cheer into the emergency room of Mexico City’s Ajusco Medio hospital, which is operating well over normal capacity because of the coronavirus pandemic.
© Provided by The Canadian Press

Dr. Marta Patricia Mancilla, head of the emergency unit, says the upbeat soundtrack is a distraction from the routine at the packed hospital, where some people have kneeled at the doors of the emergency room, praying for relatives suffering from the disease.


It has been eight months since the city-run Ajusco Medio hospital was named as one of the few exclusively COVID-19 hospitals in the city of almost nine million, and empty beds are rare.

“The worst is still to come,” Mancilla said.

“And unfortunately, it is going to catch us very tired,” she said of medical personnel who have been working constantly while themselves vulnerable to the disease. Almost 2,000 health care workers are confirmed to have died of the disease across Mexico.

The toll is psychological and physical, and is as clear as the numbers written on an erasable whiteboard in the office of Dr. Alejandro Avalos, the Ajusco Medio hospital's director: total patients are at 122% capacity, intensive care is at 116%, and the emergency unit at 100%.

“We haven't been below 100% since May,” said Avalos, whose hospital — a government facility that treats patients for free — has been temporarily expanded to meet the waves of coronavirus cases. Citywide, occupancy at hospitals was 69% this week.

Yet as full as the city's hospitals are, its streets are also once again thronged; in some more central parts of the metropolis, almost everyone wears a face mask, but in other poorer, outlying areas, fewer people do.

The situation has officials worried. Millions normally gather each year for the Dec. 12 holiday of Mexico's holy Virgin of Guadalupe day, and huge family gatherings are the norm for Christmas in Mexico.

It drew an urgent appeal from President Andrés Manuel López Obrador on Friday, who decreed an expansion of 500 more hospital beds in Mexico City and pleaded with Mexicans to stop crowding the streets and stay home in December.

“In this month, December, there are traffic problems, there are growing numbers of vehicles in the streets,” the president said. “Right now, we cannot act like this.”

López Obrador announced new hiring to help exhausted medical personnel. “There is a lot of tiredness, fatigue,” he said.

At least 13,800 people have died of COVID-19 in Mexico City alone, according to official data. Authorities say the number is probably higher in part because of limited testing, especially in the early months of the pandemic.

Methods have improved since the city's hospitals were overwhelmed in May and June, when patients were treated in hallways and relatives of the dead were not even allowed to enter the hospital to identify the bodies. The case fatality rate has dropped significantly at Avalos' hospital, but along with the improvements there has been an emotional cost.

“Our way of thinking has changed,” Avalos said. “We have learned to weep with people, to suffer with people, to understand people better.”

On Friday, the mayor didn't raise the city back to the maximum alert level as some had expected, and employers had feared because it would have required business shutdowns. But Sheinbaum said some measures that were in place during the previous maximum alert would resume, including urging people to isolate themselves voluntarily, suspending non-essential local government activities and authorizing checkpoints to limit the number of people entering the capital’s colonial-era downtown at one time.

Health care professionals' patience appears to be wearing out. Last week a group of doctors and nurses at the La Raza state hospital, one of the city's largest, signed an open letter threatening to stop treating COVID-19 patients unless the city declared a partial lockdown, as it did in the spring.

“If it was bad in May, now it's worse,” said one doctor who signed the letter, and who asked not to be identified for fear of reprisals. “There are fewer doctors," he said, due to infections, or doctors simply taking leaves of absence because they can't face the pressure, fear and overwork.

Just as bad, the anesthesia medications needed to successfully intubate patients and keep them on ventilators are running out. “It's shameful to say that some patients have to get their own PCR tests and find a hospital that will take them, because there are no beds” at the free government hospitals, he noted.

López Obrador has rejected any kind of strict lockdown, saying such measures smacked of “dictatorship.”

There are some victories; at the Ajusco Medio hospital, one of the 36 patients on ventilators has been disconnected from the machine and is recovering. A baby was born, separated from his mother who has COVID-19.

The hospital has set up tents outside to detect and triage arriving patients; some can be sent home with medications, others admitted. That has allowed the hospital to greatly increase the number of people it treats.

But the signs of wear are clear: the hospital's CT scan machine is being repaired, after having performed about 4,500 lung scans in recent months to detect coronavirus damage.

The psychological toll is also clear for patients, even those who survive.

María Eugenia Ortiz, 51, and her husband — they were both infected — came to the hospital for their third checkup since being sent home with medications. She chose to endure the disease at home because she was terrified of the hospital. At her worst moments, she struggled to breathe. Fourteen of her friends and relatives have died of the disease.

“Everything would go black and I would feel like I was floating,” Ortiz recalled. “My chest was empty and cold.”

Now, Ortiz feels more confidence in the doctors.

“Before, the doctors wouldn't help you, there was more fear, we didn't know what to do,” she said.

But attitudes change slowly; medical personnel still question whether city residents are taking the pandemic seriously enough.

“We are getting more and more fed up,” said the doctor at the La Raza hospital who himself was infected. “In Mexico, what is killing people isn't the disease itself so much as the lack of information, the poor handling of the pandemic and people's ignorance. Seeing full shopping centres is discouraging, after working a 24-hour shift.”

Mancilla, the emergency director, said: “There is a feeling of 'why do we keep risking ourselves if people aren't paying attention.' This is getting out of hand, and it is hard to keep going on like this.”

Maria Verza, The Associated Press
US Federal judge reinstates DACA, orders Homeland Security to quickly accept new applicants

A New York federal judge on Friday restored the Obama-era Deferred Action for Childhood Arrivals program — which President Donald Trump has tried to end — in a court ruling that would swiftly grant thousands of immigrants whose parents brought them to the U.S. as young children the ability to continue to work and study in the country.
© Provided by NBC News

U.S. District Judge Nicholas Garaufis said in his six-page ruling that he was fully reinstating the DACA program based on the terms established under former President Barack Obama's administration. Trump tried to end the program in September 2017, and this past July Chad Wolf, the acting secretary for the Department of Homeland Security, suspended DACA pending a “comprehensive” review.

However, Garaufis also ruled in November that Wolf has not been acting lawfully as the chief of Homeland Security and that, as such, his suspension of protections for a class of migrants brought to the United States illegally as children is invalid

The judge reaffirmed that position in his Friday ruling. Although Trump formally nominated Wolf for the job in summer, Wolf has yet to get a full vote in the Senate, keeping his role as "acting."

He also ordered DHS to post a public notice by Monday prominently on its website to accept first-time applications, renewal requests and advance parole requests based on Obama-era rules and to ensure that work permits are valid for two years.

This is the latest blow to the Trump’s administration’s efforts to halt the program. The U.S. Supreme Court ruled in June that the Trump administration wrongly tried to shut down the program. The president’s administration then began rejecting new applicants to the program this summer about a month after the High Court blocked the White House from ending the program completely.

In its ruling, the high court found that his administration was “arbitrary and capricious” in its attempt to end the Obama-era program. Existing applicants also must reapply every year, but remain in the program.

The National Immigration Law Center called the ruling a "major victory" in a tweet on Friday.

"This is a major victory for immigrant youth, led by immigrant youth. We would not be celebrating this day were it not for our courageous plaintiffs that fought to affirm that their #HomeIsHere," the organization said. "This is a day to celebrate, and we look forward to working with the incoming Biden administration to create a permanent solution for immigrant youth and communities."
US House votes to decriminalize marijuana at federal level

WASHINGTON — The Democratic-controlled House on Friday approved a bill to decriminalize and tax marijuana at the federal level, reversing what supporters call a failed policy of criminalizing pot use and taking steps to address racial disparities in enforcement of federal drug laws.
© Provided by The Canadian Press

Opponents, mostly Republicans, called the bill a hollow political gesture and mocked Democrats for bringing it up at a time when thousands of Americans are dying from the coronavirus pandemic.

“With all the challenges America has right now, (Republicans) think COVID relief should be on the floor, but instead, the Democrats put cats and cannabis” on the House floor, said House Minority Leader Kevin McCarthy, R-Calif. “They’re picking weed over the workers. They’re picking marijuana over (providing) the much-needed money we need to go forward? to address the pandemic.

McCarthy’s comment about cats referred to a separate bill approved by the House to ban private ownership of big cats such as lions and tigers, a measure boosted by the Netflix series “Tiger King.? That bill, approved by the House on Thursday, would allow most private zoos to keep their tigers and other species but would prohibit most public contact with the animals.

Democrats said they can work on COVID-19 relief and marijuana reform at the same time and noted that the House passed a major pandemic relief bill in May that has languished in the Senate.

Supporters say the pot bill would help end the decades-long “war on drugs” by removing marijuana, or cannabis, from the list of federally controlled substances while allowing states to set their own rules on pot. The bill also would use money from a new excise tax on marijuana to address the needs of groups and communities harmed by the so-called drug war and provide for the expungement of federal marijuana convictions and arrests.

“For far too long, we have treated marijuana as a criminal justice problem instead of as a matter of personal choice and public health,? said Rep. Jerry Nadler, D-N.Y., chairman of the House Judiciary Committee and a key sponsor of the bill. “Whatever one’s views are on the use of marijuana for recreational or medicinal use, the policy of arrests, prosecution and incarceration at the federal level has proven unwise and unjust.?

Drug reform advocates called the House vote historic, noting it is the first time comprehensive legislation to decriminalize marijuana has passed the full House or Senate.

“The criminalization of marijuana is a cornerstone of the racist war on drugs. Even after a decade of reform victories, one person was arrested nearly every minute last year for simply possessing marijuana,” said Maritza Perez, director of national affairs at the Drug Policy Alliance, an advocacy group. “Today the House took the most powerful step forward to address that shameful legacy.''

The vote comes at a time when most Americans live in states where marijuana is legal in some form, and lawmakers from both parties agreed that national cannabis policy has lagged woefully behind changes at the state level. That divide has created a host of problems — loans and other banking services, for example, are hard to get for many marijuana companies because pot remains illegal at the federal level.

Four states, including New Jersey and Arizona, passed referenda allowing recreational cannabis this year. Voters made Oregon the first state in the nation to decriminalize possession of small amounts of cocaine, heroin and methamphetamine.

Rep. Barbara Lee, D-Calif., called the House bill an important racial justice measure. The bill “is a major step, mind you, a major step toward ending the unjust war on drugs and racial inequities that are central to these laws,? said Lee, who is African American.

The bill, which passed 228-164, now goes to the Republican-controlled Senate, where it is unlikely to advance. A related bill that would give pot businesses access to traditional banking services has languished in the Senate after being approved by the House last year.

Five Republicans supported the bill: Reps. Matt Gaetz and Brian Mast of Florida; Tom McClintock of California, Denver Riggleman of Virginia and Don Young of Alaska.

Six Democrats opposed it: Reps. Cheri Bustos and Daniel Lipinski of Illinois; Collin Peterson of Minnesota; Chris Pappas of New Hampshire; Conor Lamb of Pennsylvania; and Henry Cuellar of Texas.

Louisiana Rep. Steve Scalise, the No. 2 House Republican, said GOP lawmakers have been pushing for weeks to bring up a bill that allows small businesses to receive another round of Paycheck Protection Program loans. Many small businesses are struggling or have closed as a result of the pandemic.

Instead of allowing a vote on the GOP bill, House Speaker Nancy Pelosi, D-Calif., is “actually focused more on legalizing pot,'' Scalise said. ”It’s just unbelievable how tone deaf (Democrats) are to these small businesses and the jobs, the families that are tied to them.”

Senate Majority Leader Mitch McConnell also mocked the bill, saying in a floor speech that “the House of Representatives is spending this week on pressing issues like marijuana. You know, serious and important legislation befitting this national crisis.''

The Big Cat Public Safety Act also is unlikely to move forward in the Senate. Sen. Ted Cruz, R-Texas, said in a tweet that Democrats were moving to “Prosecute Tiger King” rather than address issues related to the COVID-19 pandemic.

But Carole Baskin, whose animal rescue organization is featured in the Netflix series, said the legislation would culminate a decades-long effort to end abuse of tiger cubs and other big cats, and protect the public and first responders from injuries and death.

“None of these important goals are partisan in any way, and we hope the Senate will follow suit quickly to make it into law,? said Baskin, CEO and founder of Florida-based Big Cat Rescue.

Matthew Daly, The Associated Press

Five House Republicans bucked party lines and voted in favor of legislation to decriminalize marijuana at the federal level on Friday
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© Washington Examiner/Pool Five Republicans vote for bill to decriminalize marijuana

GOP Reps. Matt Gaetz (Fla.) - the only GOP co-sponsor on the bill - Denver Riggleman (Va.), Don Young (Alaska), Tom McClintock (Calif.) and Brian Mast (Fla.) joined Democrats in supporting the measure, which passed in a 228-164 vote.


The sweeping legislation includes language to remove marijuana from the federal list of controlled substances and would expunge certain marijuana convictions.

Gaetz in a floor speech said that while he doesn't think the bill is perfect, it is a step in the right direction in bringing down unjust incarcerations and potentially advance innovation in the health care industry in the United States.

"The MORE Act is flawed; it uses cannabis policy to do a great deal of social engineering to create new taxes and new programs and redistribution of assets. But I am here as the only Republican co-sponsor of the MORE Act, and I'm voting for it because the federal government has lied to the people of this country about marijuana for a generation," he said.

"We have seen a generation, particularly of black and brown youth, locked up for offenses that should not have resulted in any incarceration whatsoever. I'm also deeply troubled that the current policy the federal government inhibits research into cannabis, research that could unlock cures and help people live better lives. My Republican colleagues today will make a number of arguments against this bill, but those arguments are overwhelmingly losing with the American people," he continued.

Riggleman also noted some differences over language in the bill, but said there are inconsistencies with marijuana policy that needed to be addressed.

"The MORE Act is not perfect, but it does address problems related to federal marijuana policy," he said. "Federal marijuana policy is filled with issues and inconsistencies. I don't know why we can't draft a simple one-page bill that de-schedules marijuana and delegates this authority to the states."

Riggleman said that his brother was incarcerated for a marijuana charge, something that has shaped his stance. He said his family owns and runs a distillery, but that he will "humbly submit that alcohol can be much worse than marijuana."

"I don't think there are a lot of Republicans that have a sibling that's been incarcerated for marijuana. It was actually a felony for him. And he has such a difficult time after that, trying to get away from a felony conviction," he told The Hill.

"And it's just I think we're at a point where we have to be honest about marijuana, decriminalize it, but also allow the states to have control over how they react to and how they control marijuana."

Recreational cannabis is legal in 15 states and Washington, D.C., with 34 states having legalized medical marijuana.

The bill marked the first time either chamber has passed legislation to decriminalize cannabis on the federal level.

CANADA 

Black federal public servants file lawsuit alleging systemic discrimination

OTTAWA — Alain Babineau recalls the discriminatory hurdles he faced trying to join the RCMP in the early 1980s, including a question in his first interview about what he would do if called a word notorious for its overt racism against Black people.
© Provided by The Canadian Press

Those racist undertones followed him, though, once he became a Mountie.

His story isn't unique, he said in an interview Friday, pointing to other federal public servants, past and present, who have faced similar barriers in their careers.

This week, he is one of several current and former Black federal workers who are named as plaintiffs in a class-action lawsuit filed against the federal government, alleging systemic discrimination in how it has hired and promoted thousands of public servants for nearly half a century.

The lawsuit filed in Federal Court, which has not been certified, alleges that some 30,000 Black civil servants have lost out on "opportunities and benefits afforded to others based on their race" going back to the 1970s.

The statement of claim says the $900 million the lawsuit is seeking in damages would compensate Black public servants for the mental and economic hardships they faced.

The workers are also asking for a plan to finally diversify the federal labour force, and eliminate barriers that even employment equity laws have been unable to remove.

Babineau said some of the positions he was promoted to during his time in the RCMP were set aside for visible minority candidates. Whenever he got a promotion, Babineau said he was labelled as having only moved up because of the colour of his skin.

And when he was given a chance to help bring in diverse recruits, Babineau said he was met with a "dog-and-pony show" that didn't address hurdles that could dissuade young Black Canadians from signing up, like being assigned to largely white communities.

"People that have decision-making authority, they just go about their business, and they (are) just part of it," Babineau said, referring to systemic discrimination.

"It continues on and … they don't even realize what it is."

Many Black public servants over the years have remained relatively silent about their experiences, but that changed over the summer as the Black Lives Matter movement grew internationally, said lawyer Courtney Betty.

The Toronto-based lawyer was on a Zoom session with a group of employees over the summer to talk about the issue without any intention of pursuing legal action.

That changed, he said, after hearing some of their stories.

He pointed to one the plaintiffs, Jennifer Phillips, who works for the Canada Revenue Agency.

The statement of claim says she has worked for the agency for about 30 years, faced demeaning comments and lack of career opportunities, pointing to her being promoted only once over three decades.

"I couldn't say no, and it wasn't an easy decision, to say yes, to take this challenge on," said Betty, himself a former Justice Department lawyer.

"But I just thought that something had to be done, to at least give them some resolution after all these years."

He said the plaintiffs in the case are hoping their legal action ensures others don't have to go through the same pain they did in their careers.

Betty also said the government has provided compensation for other groups of employees that suffered similar financial pain, and taken steps to deal with systemic issues like harassment in the RCMP after lawsuits were launched.

None of the allegations in the statement of claim has been tested in court. The Treasury Board said it cannot comment on the lawsuit at this time.

The secretariat acknowledged in a statement that systemic racism is a "painful lived reality" for Black, racialized and Indigenous people in Canada.

A spokeswoman also pointed to the government's throne speech pledge to diversify the top ranks of the public service, and the $12 million over three years in this week's fall economic statement towards that end.

This report by The Canadian Press was first published Dec. 4, 2020.

Jordan Press, The Canadian Press

RUDN University mathematician suggested new approach to cooperative game

RUDN UNIVERSITY

Research News

A mathematician from RUDN University developed a matrix representation of set functions. This approach is vivid and easy to check, and it makes the calculations easier. Among other things, the new development can be applied to cooperative game theory. The results of the work were published in the Information Sciences journal.

Specialists in cooperative game theory study methods of coplex decision-making in situations with multiple criteria. In such a situation, groups (or coalitions) of players have to come up with a decision that is the most profitable for all of them. Set functions are one of the tools used to work with cooperative game theory. In these functions, the input data are sets of elements that can have different values. Simple explicit questions are quite rare in real life; therefore, the data on different elements can support or neutralize each other. Combinations of elements called coalitions can assume their own values. To work with this apparatus, scientists require an intuitive mathematical language. A mathematician from RUDN University suggested his approach to it.

"Our contribution to the mathematical language of cooperative game theory is based on the familiar notions of matrices and vectors. We have developed a formal approach to manipulations with set functions based on linear algebra. Our results can be practically applied to multicriteria decision analysis, group decision-making, operations with dependent goals, economic theories based on cooperative games, and aggregate functions theory," said Prof. Gleb Beliakov, a Candidate of Physics and Mathematics from RUDN University.

Prof. Beliakov wanted to develop a universal approach that would make expressions equally understandable and convenient for mathematicians, engineers, economists, and specialists in computer science. The best option for it was linear algebra operations based on matrices. Operations with matrices are included in most software packages and are also useful for parallel computations.

The scientist obtained matrix expressions by transforming a derived set function expression. A derived function shows how a function transforms when its variables change. Having calculated a derived function, a specialist can give an accurate analysis of a certain situation. In linear algebra, treating an exponential set this way can simplify calculation methods and support effective implementation of many formulae in software. Prof. Beliakov also suggested new formulae for finding the Shapley vector--a version of 'fair distribution' in which the profit of each player is equal to their average contribution to respective coalitions. The new method makes it easier to obtain the Shapley vector in practical applications.

"Set functions are used in economics, decision-making, fuzzy logic, and operational research. An exponential set is a particularly effective tool to model input variables in corporate games. The new apparatus could simplify calculations and support software implementation of many formulae using existing linear algebra packages," added Prof. Gleb Beliakov from RUDN University.

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Environmental exposures affect therapeutic drugs

High-resolution mass spectrometry promotes new methods for analysis

UNIVERSITY OF VIENNA

Research News

According to scientific estimations, humans are exposed to at least 10,000 to 100,000 environmental and exogenous compounds in an individual lifetime, which are mainly absorbed through our dietary. "Our body can effectively detoxify most of these substances, but various molecules as well as co-exposures can impact drug efficacy," says Benedikt Warth, deputy head of the Department of Food Chemistry and Toxicology at the Faculty of Chemistry and coordinator of the newly founded national exposome research infrastructure, EIRENE Austria.

Fragmented knowledge

Think of the well-known instruction not to drink alcohol in combination with antibiotics or pain relievers. "Ethanol is a well-studied toxin that can alter the effect of the active agent," says Warth. Bisphenol A (BPA) is another popular environmental toxin that practically everybody has accumulated in his or her body, although mostly in very low concentrations not considered to be critical for human health. BPA, a crucial component in the plastics production, has shown to interact with various anti-cancer therapeutics, which can result in drug resistance and reduced effectiveness.

Genistein, a phytoestrogen derived from soybeans and a prominent active agent in hormone drugs for menopausal symptoms, can also affect various drugs, in particular hormone-relevant chemotherapeutics against breast cancer, the researchers explain in their article. These interactions can have negative as well as positive effects.

"Among the tens of thousands to hundreds of thousands of molecules that humans are exposed to, countless could interact with therapeutics, especially under certain conditions or in critical phases of life such as pregnancy or adolescence", PhD student Manuel Pristner explains.

Exposome & health effects

"Today's high-resolution mass spectrometry enables us to measure a very large number of molecules in parallel. This way, we can systematically investigate the network of relationships between the so-called exposome, i.e. all measurable exposures, and certain active agents," says Warth. Furthermore, improved bio-informatic algorithms enable the researchers to analyse the generated big data sets.

To date, researchers have been specifically looking for the effect of a certain molecule on a specific receptor. "With the new technologies at hand, we can expand the approach and not only use a fishing rod, but a fishing net to implement a comprehensive screening strategy, which might lead to discoveries that we would not have been able to make based on rational hypothesis," say the chemists.

Personalised medicin

There are different reasons why certain active agents work well in one person and less or not at all in another, depending on an individual genome, the presence of certain receptors, the activity of enzymes or simply chemical reactivity.

An improved understanding of exposome-drug interactions could enable physicians to prescribe drugs and drug doses on an individual basis, increasing their effectiveness and minimising or even avoiding side effects. Individualised medication for a patient through a standardised pre-screening of his or her exposome "are still future dreams," according to Warth, "but the systematic approach could be ground-breaking and also benefit the early stages of drug development."

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Publication in "Trends in Pharmacological Sciences":
Manuel Pristner, Benedikt Warth: Drug-Exposome Interactions: The Next Frontier in Precision Medicine,
Volume 41, Issue 12, December 2020, Pages 994-1005. DOI: doi.org/10.1016/j.tips.2020.09.012

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

KU Leuven vaccine candidate protects against Covid-19 and yellow fever

KU LEUVEN

Research News

IMAGE

IMAGE: LAB WORKERS WORK ON INFECTED TISSUE AT THE KU LEUVEN REGA INSTITUTE view more 

CREDIT: LAYLA AERTS FOR KU LEUVEN

Virologists at the Rega Institute at KU Leuven (Belgium) have developed a vaccine candidate against Covid-19 based on the yellow fever vaccine, which as a result also works against yellow fever. Results published today in Nature show that the vaccine protects hamsters from infection with the SARS-CoV-2 coronavirus after a single dose. The vaccine is also effective in monkeys. The team is currently preparing for clinical trials.

To engineer their vaccine, tentatively named RegaVax, the team led by Professor Johan Neyts and Kai Dallmeier inserted the genetic code of the SARS-CoV-2 spikes into the genetic code of the yellow fever vaccine. The researchers tested the vaccine in healthy hamsters and monkeys. Another group of the animals received a placebo.

The researchers first vaccinated the hamsters and then dripped the virus into their noses. Ten days after a single vaccine dose, most of the hamsters were protected against the virus. Three weeks after vaccination, all hamsters were protected. "They also didn't develop any lung infections. The lungs of the hamsters in the control groups, by contrast, showed clear signs of infection and disease," Neyts explains.

The team also tested the vaccine in monkeys. "In some of the monkeys, we observed neutralising antibodies already seven days after vaccination. After fourteen days, high titers of neutralizing antibodies were measured in all animals. This is very fast. Moreover, in the vaccinated animals, the virus was completely or nearly completely gone from their throats."

CAPTION

A lab worker holds frozen virus samples at the KU Leuven Rega Institute


Long-lasting immunity

"Ours is the only vaccine currently in development against Covid-19 that also protects against yellow fever," explains professor Neyts. Previously, the Rega team used the yellow fever vaccine as the foundation for vaccine candidates against Zika, Ebola, and rabies. "The effectiveness and safety of the yellow fever vaccine, which has been in use for 80 years, is well-established. More than 500 million people have already received this vaccine. One dose offers fast protection against yellow fever that in nearly all cases lasts for life."

"A vaccine that works against Covid-19 and yellow fever could offer an important contribution to the WHO's campaign to eradicate yellow fever by 2026," Neyts continues. "Especially now that we know there are mosquito species present in Asia that can transmit the yellow fever virus."

RegaVax works after one dose, unlike many of the front-runners in the race today, which require a repeat vaccination after one month. "This has important logistical implications, in particular for countries with a less advanced medical system," explains professor Neyts. "Additionally, we expect that the vaccine will offer long-lasting immunity to Covid-19. It could therefore be an ideal candidate for repeat vaccinations when immunity decreases in people who have received one of the first-generation vaccines."

Finally, the vaccine can be stored at 2-8 °C, while some vaccines require a cold chain with temperatures down to -70 °C. That's already challenging in the Western world, but it may be nearly impossible to vaccinate large populations in remote tropical and subtropical regions," Neyts explains.

"An inexpensive, single-dose vaccine that rapidly protects against infection, that can be stored and transported at fridge temperature, and that may, like the yellow fever vaccine on which it is based, result in long-lasting immunity, provides an important and much-needed diversification of the Covid-19 vaccine landscape," Neyts concludes.

His team is now preparing for clinical trials next year and has joined forces with a specialised and accredited company that will produce the vaccine candidate for testing in humans.


CAPTION

Virologist at the KU Leuven Rega Institute in Belgium

New technique

RegaVax is a vector vaccine: it uses the genetic code of the yellow fever vaccine virus as a carrier (or vector) for the genetic code of the coronavirus spikes. "When working with a related virus, such as the Zika virus, pieces of the genetic code of the yellow fever vaccine virus are swapped with a similar piece of the code of the targeted virus. Using this strategy the team recently developed a Zika vaccine candidate. However, since SARS-CoV-2 is unrelated to yellow fever, a new technology had to be developed to insert an entirely unrelated genetic sequence in the yellow fever vaccine backbone. This concerns an important innovation in the vaccine field."

Virus inhibitors

"Mind you: vaccines are not a solution for people who are already ill. That is why we are also developing a cure to help Covid-19 patients," Neyts concludes. "We recently published on the protective activity of the Japanese flu drug favipiravir in hamsters. We have identified some other existing medicines or combinations thereof that inhibit the virus. We are now first exploring their effect in infected hamsters. At the same time, we aim to develop new and powerful virus inhibitors against SARS-CoV-2. For this purpose, we have already tested more than 1.6 million molecules in our fully automated high biosafety laboratory. We're looking for a needle in a haystack."

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Climate change warms groundwater in Bavaria

MARTIN-LUTHER-UNIVERSITÄT HALLE-WITTENBERG

Research News

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IMAGE: TEMPERATURES WERE MEASURED AT 35 GROUNDWATER STATIONS IN BAVARIA, GERMANY view more 

CREDIT: APPLIED GEOLOGY / UNI HALLE

Groundwater reservoirs in Bavaria have warmed considerably over the past few decades. A new study by researchers at Martin Luther University Halle-Wittenberg (MLU) compares temperatures at 35 measuring stations, taken at different depths, with data from the 1990s. Water found at a depth of 20 metres was almost one degree warmer on average than 30 years ago. The findings were published in the journal "Frontiers in Earth Science".

As the air warms, the ground also becomes warmer over time - ultimately resulting in warmer groundwater. Geologists call this thermal coupling. "Unlike the atmosphere, however, the earth's sub-surface is very sluggish," explains Professor Peter Bayer, a geoscientist at MLU and co-author of the study. Because the ground below the surface does not react to short-term temperature fluctuations and thus tends to reflect long-term trends, it is a good indicator of climate change.

"This ground warming effect has been known to scientists, however there is still little data on it," explains Bayer. For the new study, Bayer and his doctoral student Hannes Hemmerle repeated measurements that had been carried out in the 1990s at 35 measuring stations in groundwater reservoirs in Bavaria. The measuring points are distributed throughout the state, which provides a rare insight into the development of an entire region.

The geologists were able to show that almost all the groundwater reservoirs they investigated had warmed up in a similar way over the decades. "Climate change has a very clear effect at depths starting at around 15 metres; at that point short-term local or seasonal fluctuations can no longer be measured," explains Hemmerle. The groundwater at depths of 20 metres was, on average, nearly 0.9 degrees Celsius warmer than in the 1990s. At depths of 60 metres it was still nearly 0.3 degrees warmer. During the same period, the average air temperature rose by 1.05 degrees Celsius.

"It can be assumed that the groundwater will warm up even more as a delayed reaction to air temperatures and that it will continue to react to rising atmospheric temperatures in the future," says Hemmerle. The consequences of this warming are still difficult to gauge, says Bayer, who adds, higher water temperatures affect the growth of microbes and put pressure on underground ecosystems that are adapted to very constant temperatures.

In order to get a feel for the magnitude of the measurements, Bayer and Hemmerle also compared ground warming at a depth of 15 metres with Bavaria's annual heating requirements. Their findings: the increase in temperature correlates to about ten percent of demand. "At least a portion of the heat could possibly be reused as geothermal energy," says Bayer. However, the results cannot be directly transferred to the whole of Germany. "But it can be assumed that the trend is the same," says Hemmerle.

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The study was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation).

Hydrogen-powered heavy duty vehicles could contribute significantly to achieving climate goals

Analysis of the climate protection effect of green hydrogen on heavy duty vehicles

INSTITUTE FOR ADVANCED SUSTAINABILITY STUDIES E.V. (IASS)

Research News

A partial transition of German road transport to hydrogen energy is among the possibilities being discussed to help meet national climate targets. A team of researchers from the Institute for Advanced Sustainability Studies (IASS) has examined the hypothetical transition to a hydrogen-powered transport sector through several scenarios. Their conclusion: A shift towards hydrogen-powered mobility could significantly reduce greenhouse gas emissions and greatly improve air quality - in particular, heavy duty vehicles represent a low-hanging fruit for decarbonization of German road transport.

"Hydrogen fuel cell vehicles offer competitive advantages over battery electric vehicles regarding heavy loads, longer driving ranges and shorter fuelling times - making them particularly attractive to the heavy duty vehicle segment" explains lead author Lindsey Weger: "Moreover, transitioning heavy-duty vehicles to green hydrogen could already achieve a deep reduction in emissions - our results indicate a potential of -57 MtCO2eq annually, which translates to about a 7 percent drop in German greenhouse gas emissions for the current conditions".

Accordingly, heavy duty vehicles (which here include not only trucks but also commercial vehicles and buses) equipped with (green) hydrogen fuel cells are a possibility worth considering on the path to road transport decarbonization.

Road transport is a major source of emissions

Transport is one of the most emission-intensive sectors for both climate and air pollutants. In 2017, for example, Germany's transport sector accounted for 18.4 percent of CO2eq emissions; 96 percent of which derived from road traffic.

While Germany has successfully decreased its emissions considerably in most areas of the economy since 1990, little progress has been made in the transport sector, which is in large part responsible for Germany's failure to meet its target of a (lasting) 40 percent reduction in greenhouse gas emissions by 2020 compared to 1990 levels.

The major reasons for this are:

    - the increasing kilometres travelled;

    - the continued dominance of fossil fuels in transport;

    - and high average vehicular CO2 emissions.

Due to extraordinary circumstances, including the countermeasures adopted to contain the Covid-19 pandemic, Germany is now set to meet its original 2020 emissions reduction target. However, this reduction is not expected to be lasting, with emissions from the transport sector almost returning to their original levels in mid-June 2020.

Green hydrogen: a key to reducing emissions

The overall emissions impact depends on the method of hydrogen production: According to the analysis, emissions change between -179 and +95 MtCO2eq annually from a hypothetical full transition to hydrogen vehicular traffic, with the greatest emissions reduction afforded by green hydrogen production (i.e., zero-carbon hydrogen based on renewable-powered water electrolysis), while the greatest emissions increase results from electrolysis using the fossil fuel-intense current electricity mix. Hence green hydrogen in particular could contribute significantly towards achieving Germany's future greenhouse gas emissions reduction targets.

The green hydrogen scenario also promises to deliver the largest reduction in air pollutants - up to 42 percent for NMVOCs, NOx and CO - compared to emissions from the German energy sector for the current conditions. However, producing hydrogen with the current (fossil fuel-intense) electricity mix would result in an increase or minimal effect (i.e., no benefit) in emissions of some pollutants.

Transitioning only heavy duty vehicles to green hydrogen would already deliver a large reduction in emissions (-57 MtCO2eq). "According to our calculations, if only the HDV vehicle segment were to undergo this transition, then we would already get nearly a third of the total possible reduction, with only one third of total hydrogen demand that would be needed to fuel the entire vehicle fleet - a clear low-hanging fruit", says scientist Weger. In conclusion, the team of authors argue that commercial and large vehicles powered by hydrogen could make a rapid and substantial contribution to Germany's overall reduction in emissions.

Background information on hydrogen:

Hydrogen is a non-toxic, colourless, and odourless gas. It has been safely produced for decades and is used in industry and space research. Hydrogen has the highest energy density by mass among conventional fuels (although not by volume at standard atmospheric pressures) and, crucially, hydrogen refuelling infrastructure is comparable to that used for conventional road fuels.

In addition, hydrogen can be produced from a wide range of energy forms, including renewable electricity. It can be easily stored, compressed or liquefied either in pure form, mixed with natural gas, or bound with larger molecules. Hydrogen is easily transported by pipeline, truck, or ship. It can be safely used to fuel vehicles and is in many respects even safer than petrol and diesel.

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Cost of planting, protecting trees to fight climate change could jump

NORTH CAROLINA STATE UNIVERSITY

Research News

Planting trees and preventing deforestation are considered key climate change mitigation strategies, but a new analysis finds the cost of preserving and planting trees to hit certain global emissions reductions targets could accelerate quickly.

In the analysis, researchers from RTI International (RTI), North Carolina State University and Ohio State University report costs will rise steeply under more ambitious emissions reductions plans. By 2055, they project it would cost as much as $393 billion per year to pay landowners to plant and protect enough trees to achieve more than 10 percent of total emissions reductions that international policy experts say are needed to restrict climate change to 1.5 degrees Celsius. The findings were published today in the journal Nature Communications.

"The global forestry sector can provide a really substantial chunk of the mitigation needed to hit global climate targets," said Justin Baker, co-author of the study and associate professor of forest resource economics at NC State. "The physical potential is there, but when we look at the economic costs, they are nonlinear. That means that the more we reduce emissions - the more carbon we're sequestering - we're paying higher and higher costs for it."

The researchers found that The Intergovernmental Panel on Climate Change expects forestry to play a critical role in reducing climate change. To analyze the cost of preserving forest, preventing harvest and deforestation, and planting trees, researchers used a price model called the Global Timber Model. That model estimates costs of preserving trees in private forests owned and managed by companies for harvesting for pulp and paper products, as well as on publicly owned land, such as U.S. national parks.

"Protecting, managing and restoring the world's forests will be necessary for avoiding dangerous impacts of climate change, and have important co-benefits such as biodiversity conservation, ecosystem service enhancement and protection of livelihoods," said Kemen Austin, lead author of the study and senior policy analyst at RTI. "Until now, there has been limited research investigating the costs of climate change mitigation from forests. Better understanding the costs of mitigation from global forests will help us to prioritize resources and inform the design of more efficient mitigation policies."

The researchers estimated it would cost $2 billion per year to prevent 0.6 gigatons of carbon dioxide from being released by 2055. Comparatively, $393 billion annually would sequester 6 gigatons, or the equivalent of emissions from nearly 1.3 billion passenger vehicles driven for one year, according to the U.S. Environmental Protection Agency's Greenhouse Gas Equivalencies Calculator.

"It's not clear from these results that you'll have consistent low-cost mitigation from the global forest sector as other studies have indicated," Baker said.

The tropics are expected to play the biggest role in reducing emissions, with Brazil - the country that contains the largest share of the Amazon rainforest - the Democratic Republic of Congo, and Indonesia contributing the largest share. The tropics will contribute between 72 and 82 percent of total global mitigation from forestry in 2055.

The researchers also found that forest management in temperate regions, such as forestland in the southern United States, will play a significant role, especially under higher price scenarios. They expect that afforestation, which is introducing trees to areas that are not actively in forest, and managing existing forestland will be important strategies in the United States.

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The paper, "The economic costs of planting, preserving and managing the world's forests to mitigate climate change," was published in Nature Communications on Dec. 1. In addition to Austin and Baker, other authors included B.L. Sohngen, C.M. Wade, A. Daigneault, S.B. Ohrel, S. Ragnauth and A. Bean. The study was supported by the U.S. Environmental Protection Agency.

Note to editors: The abstract follows.

"The economic costs of planting, preserving and managing the world's forests to mitigate climate change"

Authors: K.G. Austin, J. Baker, B.L. Sohngen, C.M. Wade, A. Daigneault, S.B. Ohrel, S. Ragnauth, and A. Bean.

Published: online in Nature Communications on Dec. 1.

DOI: 10.1038/s41467-020-19578-z

Abstract: Forests are critical for stabilizing our climate, but costs of mitigation over space, time, and stakeholder group remain uncertain. Using the Global Timber Model, we project mitigation potential and costs for four abatement activities across sixteen regions for carbon price scenarios of $5 - $100/tCO2. We project 0.6 - 6.0 GtCO2yr-1 in global mitigation by 2055 at costs of 2 - 393 billion USD/yr, with avoided tropical deforestation comprising 30 - 54% of total mitigation. Higher prices incentivize larger mitigation proportions via rotation and forest management activities in temperate and boreal biomes. Forest area increases 415 - 875 Mha relative to the baseline by 2055 at prices $35 - $100/tCO2, with intensive plantations comprising <7% of this increase. Mitigation costs borne by private land managers comprise less than one-quarter of total costs. For forests to contribute ~10% of mitigation needed to limit global warming to 1.5?C, carbon prices will need to reach $281/tCO2 in 2055.