Wednesday, July 15, 2020

How to strengthen New Zealand's proposed cannabis legalization and control bill

SOCIETY FOR THE STUDY OF ADDICTION MEANS THEY ARE ANTI DRUGS
Two drug policy experts have identified gaps and challenges in New Zealand's proposal for legalizing recreational cannabis. In advance of a widely-watched national referendum vote to be held this September, Associate Professor Chris Wilkins and Dr. Marta Rychert of Massey University argue in the pages of Addiction that New Zealand's Cannabis Legislation and Control Bill (CLCB) needs to be strengthened in two critical areas:
Set a formal minimum price for cannabis: The legalization of cannabis in other jurisdictions has resulted in significant declines in the legal price of cannabis. Minimum unit pricing has been shown to be effective at reducing alcohol consumption levels and related harms. The CLCB includes a discretionary power to raise the excise tax for cannabis for a maximum of 12 months if the price of cannabis drops below the level consistent with purposes of the Act. This discretionary power lacks clear criteria for activation and thus falls short of a clear minimum price provision.
Lower the potency cap for cannabis products: High potency cannabis is associated with increasing first-time cannabis treatment admissions, transition to daily use, cannabis dependence and higher risk of psychosis and psychosis relapse. The CLCB's maximum potency levels for cannabis plant (15% THC) appears to be at the higher end of those currently found in the black market in New Zealand. Potency levels for edibles and extracts are expressed as milligrams "per unit" and "per package" without defining what constitutes a unit or package. (Edibles and concentrates will not initially be sold but they are included in the CLCB for future approval.)
Wilkins and Rychert also identify two public health objectives of the CLCB that will be difficult to achieve:
Difficulties reducing cannabis use over time via a commercial market: The CLCB largely proposes a commercial cannabis market with provisions for non-commercial and not-for-profit supply. The CLCB objective of lowering cannabis use over time appears at odds with the proposed commercial cannabis sector, which will focus on expanding sales. Non-commercial or not-for-profit operators can provide legal access to cannabis while avoiding profit driven commercial companies.
Difficulties taxing products by THC potency: The CLCB proposes a progressive product excise tax based on THC potency and weight. Considerable work will be required to implement a potency-based tax, including consistent sampling procedures, certified testing facilities, and effective auditing to prevent producers gaming the system. Also, the reliability and replicability of testing THC is problematic. A weight-based tax (similar to the taxation of tobacco) may be a more practical alternative for now.
Dr Wilkins says: "The New Zealand referendum vote will be the first time a country will have the opportunity to vote on a comprehensive regulatory framework to legalise cannabis rather than a general question asking whether cannabis should be legal or not. It's therefore important that New Zealand voters clearly understand the strengths and weaknesses of the proposed CLCB."
Wilkins and Rychert provided feedback on the first draft of the CLCB to the New Zealand Ministry of Justice Cannabis Referendum Team, along with a number of other anonymous experts and public commentators. The authors received no financial or non-financial remuneration for these comments.
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For editors:
Peer reviewed: Yes
Type of study: Policy analysis
Subject of study: People
Funding: Government/research council
This paper is free to download for one month from the Wiley Online Library: https://onlinelibrary.wiley.com/doi/abs/10.1111/add.15144 or by contacting Jean O'Reilly, Editorial Manager, Addictionjean@addictionjournal.org.
To speak with lead author Dr Chris Wilkins: contact him at Massey University (New Zealand) by email (c.wilkins@massey.ac.nz) or telephone (+64 (09) 414 0800 ext. 41330).
Full citation for article: Wilkins C and Rychert M (2020) Assessing New Zealand's Cannabis Legalisation and Control Bill: Prospects and Challenges. Addiction 115: doi: 10.1111/add.15144.
Funding: The work in this paper was supported by external research funding from the New Zealand Royal Society Marsden Grant (MFP_MAU1813).
Addiction is a monthly international scientific journal publishing peer-reviewed research reports on alcohol, substances, tobacco, and gambling as well as editorials and other debate pieces. Owned by the Society for the Study of Addiction, it has been in continuous publication since 1884. Addiction is the number two journal in the 2019 ISI Journal Citation Reports ranking in the substance abuse category (science and social science editions).

Social media inspired models show winter warming hits fish stocks

UNIVERSITY OF QUEENSLAND
IMAGE
IMAGE: MATHEMATICAL MODELLING INSPIRED BY SOCIAL MEDIA IS IDENTIFYING THE SIGNIFICANT IMPACTS OF WARMING SEAS ON THE WORLD'S FISHERIES. view more 
CREDIT: THE UNIVERSITY OF QUEENSLAND
Mathematical modelling inspired by social media is identifying the significant impacts of warming seas on the world's fisheries.
University of Queensland School of Veterinary Science researcher Dr Nicholas Clark and colleagues from the University of Otago and James Cook University have assembled a holistic picture of climate change's impacts on fish stocks in the Mediterranean Sea.
"Usually, when modelling ecosystems to understand how nature is changing, we build models that only focus on the effects of the environment," Dr Clark said.
"But it's just not accurate enough.
"Newer models - commonly used in social media to document people's social interactions - offer an exciting way to address this gap in scientific knowledge.
"These innovative network models give us a more accurate picture of reality by incorporating biology, allowing us to ask how one species responds to both environmental change and to the presence of other species, including humans."
The team used this technique to analyse fish populations in the Mediterranean Sea, a fisheries-based biodiversity hotspot with its future under threat from rapidly warming seas.
"Experts from fisheries, ecology and the geographical sciences have compiled decades of research to describe the geographical ranges for more than 600 Mediterranean fish species," Dr Clark said.
"We put this information, along with data from the Intergovernmental Panel on Climate Change's sophisticated climate models into our network model.
"We found that warming seas - particularly in winter - have widespread effects on fish biodiversity."
The University of Otago's Associate Professor Ceridwen Fraser said winter warming was often overlooked when people thought about the impacts of climate change.
"A great deal of research and media attention has been on the impacts of extreme summer temperatures on people and nature, but winters are getting warmer too," Dr Fraser said.
"Interestingly, coastal water temperatures are expected to increase at a faster rate in winter than in summer.
"Even though winter warming might not reach the extreme high temperatures of summer heatwaves, this research shows that warmer winters could also lead to ecosystem disruption, in some cases more than hotter summer warming will.
"Our results suggest that winter warming will cause fish species to hang out together in different ways, and some species will disappear from some areas entirely."
The researchers hope the study will emphasise the need to understand and address climate change.
"If fish communities are more strongly regulated by winter temperatures as our model suggests, this means that fish diversity may change more quickly than we previously thought," Dr Clark said.
"Catches for many bottom-dwelling and open-ocean fishery species in the Mediterranean Sea have been steadily declining, so any changes to fish communities may have widespread economic impacts.
"For the sake of marine ecosystems and the people whose livelihoods depend on them, we need to gain a better understanding of how ocean warming will influence both species and economies."
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The research has been published in Nature Climate Change (DOI: 10.1038/s41558-020-0838-5) and included contributions from James Cook University's Dr James Kerry.

Women, newborns, young children and adolescents lose 20 percent of health and social services to COVID-19

'COVID-19 is making a bad situation worse'
UN SECRETARY-GENERAL'S INDEPENDENT ACCOUNTABILITY PANEL FOR EVERY WOMAN, EVERY CHILD, EVERY ADOLESCENT
Women, newborns, young children and adolescents are losing 20 percent of their health and social services due to the COVID-19 pandemic says a Panel of senior global health experts.
"Health systems in both rich and poor nations are massively struggling and the services for mothers, newborns, young children and adolescents are crumbling," says Elizabeth Mason, M.D, co-chair of the UN Secretary-General's Independent Accountability Panel (IAP) for Every Woman, Every Child, Every Adolescent reviewing the impact of COVID-19 on these groups.
"Especially worrisome are declines in access to life-saving vaccines for children and maternal health services due to closures and movement restrictions. Immunization campaigns are being halted and health workers are being diverted from maternity to COVID-19 units," Dr. Mason adds.
The Panel provides an overview of estimated impacts from COVID-19 pandemic on women, newborns, young children and adolescents since its start in January.
  • 5.3 million deaths in children under 5 by pre-pandemic estimates, and over 400,000 additional deaths due to COVID-19-related disruptions in services.
  • 2.5 million newborn deaths pre-pandemic, with a minimum of 168,000 additional deaths estimated.
  • 295,000 maternal deaths pre-pandemic, with an additional 24,400 additional deaths estimated.
  • 13.5 million children missed vaccinations against life-threatening diseases.
  • More than 20 countries reported vaccine shortages caused by the pandemic.
  • Disruption to contraceptive supplies leading to 15 million unintended pregnancies among women and adolescent girls in low- and middle-income countries.
  • 'Backdoor' legislation being pushed through that adversely affects the sexual and reproductive health and rights of women and adolescents
  • Around 42-66 million children risk falling into extreme poverty.
  • Some 370 million children are missing school meals.
  • Adolescents facing increasing social isolation and mental health challenges
  • Women disproportionally suffering increased depression, anxiety and uncertainty.
  • 15 million additional acts of violence against women and girls every three months of lockdown. In some countries, emergency calls increased by 30 percent.
      "These new findings show how weak our health systems are at protecting mothers, newborns, young children and adolescents," says Joy Phumaphi, co-chair of the Panel and former WHO Assistant Director-General. "We are at a point where decades of progress for this group could be easily reversed."
      The COVID-19 pandemic has interrupted steady progress and has led to increased poverty and unemployment. Early data finds women experience not only loss of various categories of support and social safety nets, but also an inability to access increased support, compared to men.
      "COVID-19 is making a bad situation worse," says Ms. Phumaphi, reflecting the conclusion of the Panel's report (at https://bit.ly/2ZPuTfH).
      "The lives' of every mother, newborn, child and adolescent matter," says Giorgi Pkhakadze, a professor of Epidemiology and Public Health, David Tvildiani Medical University, Georgia. "Quality healthcare is not a luxury, but a life-saving resource."
      Since 2000, maternal and children under 5 deaths have been cut by 40 percent, because of focused leadership and investment, even in the poorest nations. Also, in the last decade, more than $50 billion has been raised through the Every Woman Every Child movement to meet the health and medical needs of this vulnerable group. Even the poorest countries have shown progress, especially in reducing under 5 mortality.
      The Scorecard
      To understand and analyze the basic needs and gaps for mothers, newborns, young children and adolescents by country, the Panel has created a Scorecard for 193 nations, by income category, of seven key indicators (see the full Scorecard at https://bit.ly/38xi4KJ):
    • Maternal mortality ratio (per 100,000 live births)
    • Stillbirth rate (per 1,000 total births)
    • Neonatal mortality rate (per 1,000 live births)
    • Under-5 mortality rate (per 1,000 live births)
    • Adolescent mortality rate (per 100, 000 population)
    • Birth registration (proportion of children under 5 years with civil authority registered births)
    • Death registration (completeness of cause-of-death data)
      Each indicator for the 193 countries is colour-coded to depict a country's current status relative to global/country targets: dark green for surpassed, light green for advanced, yellow for intermediate, and red for catching-up countries.
      "The colour-coding makes it easy to pick out the countries where mothers, newborns, young children and adolescents are thriving and countries where they need help," says Dr. Nicholas Alipui, M.D., a visiting scholar at Yale University and former UNICEF Director of Programmes.
      Countries with all dark green surpassed in all seven categories are Finland, Iceland, Slovenia, Luxembourg, Japan, Norway, Estonia Sweden, Italy, Spain, Czechia, Austria, Belgium, Ireland, Germany, Australia, Israel, Portugal, Netherlands, France, Switzerland, Denmark, United Kingdom, Hungary, Poland, Greece, Croatia, Canada, Slovakia, Malta, Bahrain, Belarus, Cuba, Republic of North Macedonia.
      Countries that are all dark green, surpassed global targets - except for a light green, advanced ranking for adolescent deaths are: Latvia, Lithuania, New Zealand, United States, Uruguay, Seychelles, Bulgaria, Russian Federation, Romania, Costa Rica, Georgia, Kazakhstan
      Countries that are mainly red, catching up are Mauritania, Cameroon, Angola, Lesotho, Côte d'Ivoire, Nigeria, Guinea Bissau, the Democratic Republic of the Congo, South Sudan, Sierra Leone, Central African Republic, Chad, Somalia.
      The gap between rich and poor countries is huge. For example: Under 5 mortality rate (per 1,000 live births): Finland -1.7, Iceland and San Marino -2, Slovenia 2.1, Cyprus and Luxembourg -2.4, and Japan -2.5. That compares to the Central African Republic -116.5, Chad -119, Nigeria -119.9, and Somalia -121.5.
      On maternal mortality ratio (per 100,000 live births): Norway, Italy, Poland and Belarus - 2, Finland, Czechia, Greece and United Arab Emirates -3. That compares to Nigeria - 917, Sierra Leone -1,120, Chad -1,140 and South Sudan -1,150.
      Ethnic minority communities even in the wealthiest countries have large disparities of both morbidity and mortality. A number of factors create disparities: racism, low wages, limited opportunities, and poor education. This exacerbates poor health, lack of access to health, water and sanitation.
      Women, children and adolescents in countries with access to similar economic resources sometimes experience different health outcomes. For example, the United States spends more than twice as much on health than either Japan or France, yet children in the US are more likely to die before their 5th birthday and women are more than twice as likely to die in childbirth.
      Another example: Nigeria spends around 74 USD per capita on health, compared to 34 USD in Tanzania. However, Nigeria has more than double the child mortality rate compared to Tanzania, 120 and 53 deaths per 1,000 live births, respectively. This reflects significant inequalities and other disparities.
      "Critical gaps in quality health service delivery and financial protection require urgent remedy and action," says Dr. Alipui. "These gaps are found between countries and within countries."
      Losing ground
      Besides the loss of services due to the pandemic, IAP has found that globally implementation is 20 percent behind on the UN's 2030 goals (Every Woman Every Child - the Global Strategy for Women's, Children's and Adolescent's Health 2016-2030) to reduce preventable deaths for mothers, newborns, young children and adolescents.
      The UN goals include:
      •   Maternal deaths- a global decline to less than 70 deaths per 100,000 live births.
      • Newborn deaths- each country reduces to at least as low as 12 deaths per 1000 live births.
      • Children under 5 deaths - each country reduces to at least as low as 25 deaths per 1000 births.
      More than 190 countries have agreed to these targets.
      The IAP's 2020 report, published this week, calls for leaders to fulfill their commitments and lays out the action needed to get back on track. Commitments to universal health coverage, primary health care, International Health Regulations and sustainable development, were urgently needed before the pandemic. Now with COVID-19, they are even more important.
      About 2 USD trillion a year lost due to inefficiencies, corruption and waste
      Besides the 20 percent deficit, the Panel found that 2 trillion USD a year is lost to health expenditures, due to inefficiencies, corruption and waste.
      "How money is spent is every bit as important as how much is spent to improve health and socioeconomic benefits," points out Ms. Phumaphi. "The key is full accountability which connects commitment to progress."
      "A key element to sustainable progress is strong citizen voices which advocate for full accountability at all levels, community, state and national," says Dr. Alipui.
      "Mass protests clamouring for racial justice in both health and policing in the United States and around the globe have laid bare how central accountability is to achieving justice and a fairer world," explains Alicia Ely Yamin, LLD and a senior fellow in global health and rights at Harvard Law School. 
      The seven big "Lacks"
      There are still a host of basic problems blocking advancement of the health of mothers, newborns, young children and adolescents. These "lacks" relate to commitments that world leaders have made at the highest level. The UN's Sustainable Development Goals, High-level Political Declaration on Universal Health Coverage and the Every Woman Every Child Global Strategy are examples of commitments at the highest level, and yet these gaps persist.
      1. Health workers. The world needs an additional 18 million health workers.
      2. Health Data. Data emerging from countries on COVID-19 has been incomplete.
      Estimates and projections based on modeling to assess country risks and progress on COVID-19 and the health of mothers, newborns, young children and adolescents vary widely. Thus, outcomes end up patchy. The lack of relevant and accurate data constrains governments' abilities to make informed decisions to ensure people's health and wellbeing of this vulnerable group.
      Often, simple information has not been collected. Globally, one in 4 births of children under five are not registered with a civil authority; only 93 out of 193 countries are currently able to register more than 80 percent of adult deaths.
      3. Accountability. Accountability is a must-have, not a nice-to-have. It must be permanently embedded so that every leader and every government is obliged to do what they have committed to do. Private sector and development partners should 'do no harm' and provide assistance and technical cooperation to help countries make progress on health targets. Citizens need to participate fully and voice their experiences.
      "Accountability connects commitments to progress in a justifiable and constructive way," says Shyama Kuruvilla, Ph.D. who directs the Panel's secretariat. "As the Panel's report shows, accountability is critical to accelerate improvement."
      For the accountability cycle to work, a formal, institutionalized relationship is needed between the monitoring, review and recommendations, and the remedy and action that follows.
      By investing in institutionalizing accountability processes, countries can increase their capacity to apply lessons rapidly and effectively during and after events such as the COVID-19 pandemic and to rectify and remedy problems.
      4. Underinvestment in common goods for health. Common goods for health (such as for legislation and regulation, health surveillance and information, population services, and communication) form the foundation for strong health systems that are resilient and responsive, not only to population health needs but also to emergencies. The lack of these critical investments in public goods for health, both national and international, have shown up in the fault lines of the COVID-19 response with millions of people's lives, health and livelihoods put at risk, especially mothers, newborns, young child and adolescents.
      5. Universal Health Coverage and Primary Health Care. On the path to universal health coverage (quality health services and financial protection), only between one-third and one-half of the world's population were covered by the essential health services they need, including interventions for women, children and adolescents. More than 900 million people experienced catastrophic health expenditure last year. One of the smartest investments that countries can make is in primary health care. Investing an additional 200 billion USD a year on scaling up primary health care across low- and middle-income countries could save 60 million lives and increase average life expectancy by 3.7 years by 2030 and contribute significantly to socio-economic development.
      6. Progress across other sectors, e.g. water, sanitation and hygiene. From 2000 to 2017, the population using safely managed sanitation services increased from 28 percent to 45 percent. Though 60 percent of the global population has basic hand-washing facilities with soap and water available at home, 3 billion people still lack such facilities and 1.4 billion had no facilities at all. The United Nations warns that the risk of disruption to these services from lockdowns endangers health, especially from waterborne diseases, and the containment of COVID-19.
      7. Inequities are a critical concern. There are gaping gaps between rich and poor, and racial discrimination, geographical and other factors limit access to services. Capital regions often have higher coverage of basic health and multisectoral services than other sub-regions demonstrating sub-national inequalities. Inequities will worsen from the COVID-19 pandemic, compounded by lack of financial and social protection, and the most vulnerable, including women, children and adolescents would be hardest hit.
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      Accountability: Connecting commitment to progress -in a justifiable and constructive way
      The IAP sets out an accountability framework with four pillars: Commit, Justify, Implement, Progress. Every single one of these pillars must be present for effective accountability -if just one of them is missing, the whole structure falls:
      Commit: all those who have commitments and a responsibility to act should be clear on and commit to their roles and obligations towards achieving agreed goals and rights. 
      Justify: decisions and actions related to commitments must be supported and explained on the basis of evidence, rights and the rule of law. 
      Implement: core accountability functions of Monitor-Review-Remedy-Act should be institutionalized and implemented. 
      Progress: continuous progress towards agreed goals and rights should be ensured, justifying any reversals - this is the human rights principle of 'progressive realization.'

    COVID-19: Considering meditation and yoga as adjunctive treatment

    MARY ANN LIEBERT, INC./GENETIC ENGINEERING NEWS
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    IMAGE: DEDICATED TO RESEARCH ON PARADIGM, PRACTICE, AND POLICY ADVANCING INTEGRATIVE HEALTH view more 
    CREDIT: MARY ANN LIEBERT, INC., PUBLISHERS
    New Rochelle, NY, July 13, 2020--The anti-inflammatory and other beneficial effects of meditation and yoga practices make them potential adjunctive treatments of COVID-19, according to the peer-reviewed journal JACM, The Journal of Alternative and Complementary Medicine. Click here to read the article.
    Deepak Chopra, University of California, San Diego and William Bushell of Massachusetts Institute of Technology and co-authors from Harvard University and Harvard T.H. Chan School of Public Health describe the anti-inflammatory effects associated with meditation and yoga.
    The "brief overview of key subjects" found "there is evidence of stress and inflammation modulation, and also preliminary evidence for possible forms of immune system enhancement, accompanying the practice of certain forms of meditation, yoga, and pranayama, along with potential implications for counteracting some forms of infectious challenges." The authors also "readily acknowledge that in the context of the SARS-CoV-2 pandemic, the ideas put forth in this article must be put to further rigorous scientific investigation."
    JACM Editor-in-Chief John Weeks, johnweeks-integrator.com, Seattle, WA, states: "The paper is another in a series in JACM and in other integrative medicine journals suggesting that research agencies in the United States and Europe would serve their citizens by upping their exploration of the potential contributions of natural health practices, especially amidst the present dearth of conventional treatments."
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    About the Journal
    About the Journal JACM, The Journal of Alternative and Complementary Medicine is a monthly peer-reviewed journal published online with open access options and in print that is dedicated to research on paradigm, practice, and policy advancing integrative health. Led by John Weeks (johnweeks-integrator.com), the co-founder and past Executive Director of the Academic Collaborative for Integrative Health, JACM publishes human clinical trials, observational studies, systematic reviews and commentary intended to help healthcare professionals, delivery organization leaders, policy-makers and scientists evaluate and integrate therapies into patient care protocols, payment strategies and appropriate protocols. Complete tables of content and a sample issue may be viewed on the JACM website.
    About the Publisher
    Mary Ann Liebert, Inc., publishers known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research. A complete list of the firm's 90 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.

    Consumer-created social media visuals capture consumer brand perceptions

    Researchers analyzed consumer- and firm-created brand imagery to examine gaps in consumer brand perceptions and firm brand positionings
    INSTITUTE FOR OPERATIONS RESEARCH AND THE MANAGEMENT SCIENCES
    Key Takeaways:
    • Social media visuals are overtaking text in defining online brand conversations.
    • User-generated visuals are reflective of consumer brand perceptions.
    • Researchers developed a new model called BrandImageNet to map images to perceptual attributes of a brand.
    • Firms can use the BrandImageNet model to automatically monitor consumers' brand perceptions and examine the effectiveness of their positioning strategies.
    CATONSVILLE, MD, July 13, 2020 - New research has found that there is a strong link between the visual portrayal of a brand in online imagery created by consumers and the larger brand perceptions.
    The research study, to be published in the July/August issue of the INFORMS journal Marketing Science, is titled "Visual Listening In: Extracting Brand Image Portrayed on Social Media" and is authored by Liu Liu of the University of Colorado, Daria Dzyabura of the New Economics School in Russia, and Natalie Mizik of the University of Washington.
    According to the authors, their research sought to measure how brands are portrayed on social media and how it relates to brand perceptions. Their goal was to better understand consumer brand perceptions and attitudes toward brands reflected in the imagery consumers post on digital platforms.
    "Consumer-created brand images on social media are different from product images on retailer websites," said Liu. "Consumer-created brand imagery posted on social media depicts consumers' interactions with brands and links brands with usage context, feelings, and consumption experiences."
    The researchers argued that these consumer-generated images send a powerful message as a form of testimonial for other consumers. They also offer the brand owners the opportunity to understand consumers' brand perceptions.
    "In much of the prior research in this area, the focus has been on text content," said Liu. "Given that images are on their way to surpassing text as the medium of choice for online conversations, monitoring visual content is important to get a more complete understanding of online conversations involving brands."
    In the process, the researchers introduced a "visual listening in" approach to monitor visual brand content that was created and shared by the actual consumers on social media. They developed and validated a model, BrandImageNet, to allow firms to monitor their brand portrayal on social media and evaluate it relative to competitors' and their own firm's desired brand positioning.
    "Our BrandImageNet model maps images to specific perceptual attributes," said Liu. "We focused on identifying perceptual brand attributes rooted in brand images. This is different from identifying functional attributes of the product itself. One example we use in our research is a comparison between the Prada and Eddie Bauer brands. Which one is portrayed by social media users, visually, as the more glamorous and which one is the more rugged one? Our model unequivocally points to Prada as glamorous and Eddie Bauer as rugged. Across all brands in our study, we find a strong link between model predictions and consumer brand perceptions collected with traditional survey-based methods."
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    About INFORMS and Marketing Science
    Marketing Science is a premier peer-reviewed scholarly marketing journal focused on research using quantitative approaches to study all aspects of the interface between consumers and firms. It is published by INFORMS, the leading international association for operations research and analytics professionals. More information is available at http://www.informs.org or @informs.
    Domestic violence increased in the great recession

    UC Davis study suggests preparing for similar issues in COVID-19
    UNIVERSITY OF CALIFORNIA - DAVIS
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    IMAGE: A FIGURE FROM THE STUDY SHOWS INCIDENTS OF DOMESTIC VIOLENCE THAT REQUIRED EITHER AN EMERGENCY ROOM VISIT OR HOSPITALIZATION BY RATES PER 100,000 OF POPULATION. THE NUMBERS SHOW A MARKED... view more 
    CREDIT: COURTESY OF STUDY RESEARCHERS
    Emergency room visits for domestic violence incidents in California more than tripled during the Great Recession compared to the years before, signaling a need to prepare for similar and more prolonged effects during the COVID-19 financial crisis, suggest University of California, Davis, researchers.
    Conducting one of the first studies to date examining the impact of a modern recession on hospital and emergency room visits, researchers found that physical abuse in adults increased substantially between the time periods, with Black and Native American people being disproportionately affected. Violence against children did not show a marked increase. The results were published in Preventive Medicine in June.
    "The results from our study shine a spotlight on the importance of domestic-violence-related screening, prevention and response during the next several months of the COVID-19 financial effects," said the study's primary author, Alvaro Medel-Herrero, project scientist for the UC Davis Center for Health and the Environment. "Notably, domestic violence is grossly under-reported, and cases that end up in the emergency room or result in a hospital stay are only the most egregious examples. This tells us there may be an even larger problem than the numbers can show."
    The study's co-authors included Suzette Smiley-Jewel, of the UC Davis School of Veterinary Medicine; Martha Shumway, Department of Psychiatry, University of California, San Francisco; Amy Bonomi, Michigan State University; and Dennis Reidy, School of Public Health, Georgia State University.
    Study looked at 53,000 domestic violence episodes
    The study's authors looked at more than 53,000 domestic-violence-related episodes, composed of both intimate partner violence as well as violence against elders and children, between 2000 and 2015. The numbers were drawn from California's Office of Statewide Health Planning and Development, or OSHPD, and then broken down between the years during, before and after the Great Recession. While the Great Recession officially lasted less than two years, from December 2007 to June 2009, during which the gross domestic product contracted, the economic crisis produced long-lasting consequences for individuals as well as society as a whole, researchers said.
    "Proactive outreach is especially needed for minoritized people, who may be especially isolated, experiencing disconnections from services, and facing extreme financial stress," said one of the co-authors, Bonomi, of Michigan State University.
    Blacks more than three times more likely to be victims
    Time series for the study were divided into pre-recession (January 2000-November 2007) and recession/post-recession (December 2007-September 2015) periods. Blacks were more than three times more likely to suffer domestic violence during the recessionary period when compared with other segments of the California population, according to the data. Statistics showed that there were 3.58 emergency room visits per 100,000 population compared to 10.42 emergency visits per 100,000 people for Blacks. Hospitalization rates remained relatively similar from the pre-recession as compared to the recession/post-recession period except for Native Americans, which nearly doubled.
    Emergency visits vastly exceeded hospitalizations during the 2007-2015 time period.
    Additionally, the number of California police calls for weapon-involved domestic violence episodes steadily increased from 2008 (65,219) to 2014 (75,102).
    Costs associated with domestic violence
    For the period analyzed (2000-2015), the estimated total charge for all analyzed domestic violence hospitalizations was more than $1 billion (data was not available for emergency department costs).
    Length of hospital stays slightly increased during the recession/post-recession period as compared to the pre-recession period, yet the inflation-adjusted charge per hospitalization dramatically increased over time, according to the study.
    Domestic violence rate does not correspond with other hospital visits
    It is important to note that the described increase in domestic-violence-related hospitalizations during the recession does not correspond to a general trend in health care in California. For example, California cancer hospital rates dropped during the Great Recession, according to OSHPD data. However, an increasing demand for emergency care during the recession and post-recession period has been reported and may reflect limitations in accessing care in other parts of the health care system, researchers said.
    The authors' research will continue.
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    The research was supported by a UC Davis Feminist Research Institute seed grant.
    Large Lot Program shows the power of private land stewardship in addressing urban vacancy

    USDA FOREST SERVICE - NORTHERN RESEARCH STATION
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    IMAGE: SCIENTISTS WITH THE USDA FOREST SERVICE AND THE UNIVERSITY OF ILLINOIS FOLLOWED CHICAGO'S LARGE LOTS PROGRAM OVER 5 YEARS TO EXAMINE THE VISUAL AND SOCIAL EFFECTS OF RESIDENT-DRIVEN URBAN GREENING... view more 
    CREDIT: USDA FOREST SERVICE PHOTOGRAPH
    In the past 5 years, Chicago residents have purchased nearly 1,300 vacant lots and replaced weed trees and sagging fences with gardens and children's play areas. In doing so, they have demonstrated that transferring city-owned vacant lands to local residents can be a successful strategy for cities seeking to reduce blight and strengthen neighborhoods.
    In assessing the potential benefits of the City of Chicago's "Large Lot Program," a team led by scientists Paul Gobster of the USDA Forest Service's Northern Research Station and William Stewart of the University of Illinois examined the visual and social effects of resident-driven urban greening efforts in high-vacancy areas of the city's south and west sides. In their most recent paper, published last week in the journal Landscape and Urban Planning, the research team found that the program has resulted in continued improvements in the condition and care of the purchased "large lots" over a 5-year period and that these improvements were consistent across all five community areas studied.
    "While planners around the world are experimenting with ways to address urban vacancy, few cities have the tools to assess how well their programs work after they are implemented," Gobster said. "In this latest paper we develop a practical monitoring tool, the condition-care scale, and detail how it can be implemented by planners to assess the progress of vacant lot repurposing programs. The scale also holds promise for other applications related to urban greening and we encourage others to adapt it to their particular needs.
    Previously reported findings from the study showed that visible changes to large lots in the year after purchase Ied to increases in lot "cues to care" including ornamental and vegetable gardens and social and recreational features, and that levels of lot condition and care were highest for owners who lived closest to their purchased large lot.
    "In focus groups and a mail survey of large lot owners, we also found that residents who are improving the lots are gaining a stronger sense of place and belonging to their neighborhood, and they see the program is fulfilling community goals," Stewart said. "Together our visual and social assessments show that ownership matters, and that through private stewardship of vacant neighborhood lands the Large Lot Program is helping to address issues of environmental and economic justice in communities that have been disenfranchised for decades." The researchers' next step is to try and quantify whether participating in the Large Lot Program is leading to broader social outcomes, including reductions in crime.
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    The City of Chicago collaborated with community groups to launch the Large Lot Program in 2014. Initially focused on the Greater Englewood area on the city's south side, the program aims to reduce the inventory of more than 11,000 city-owned vacant lots by offering them to neighbors for $1; nearly 1,300 vacant lots have been purchased to date.
    Co-authors of the new paper, "The Condition-Care Scale: A Practical Approach to Monitoring Progress in Vacant Lot Stewardship Programs," include Alessandro Rigolon of the University of Utah and Sara Hadavi of Kansas State University. The paper is available through the Northern Research Station at https://www.nrs.fs.fed.us/pubs/60442
    Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news rele

    The new tattoo: Drawing electronics on skin

    MU engineers discover the possibility of using pencils to draw bioelectronics on human skin
    UNIVERSITY OF MISSOURI-COLUMBIA
    IMAGE
    IMAGE: ONE DAY, PEOPLE COULD MONITOR THEIR OWN HEALTH CONDITIONS BY SIMPLY PICKING UP A PENCIL AND DRAWING A BIOELECTRONIC DEVICE ON THEIR SKIN. IN A NEW STUDY, UNIVERSITY OF MISSOURI... view more 
    CREDIT: UNIVERSITY OF MISSOURI
    One day, people could monitor their own health conditions by simply picking up a pencil and drawing a bioelectronic device on their skin. In a new study, University of Missouri engineers demonstrated that the simple combination of pencils and paper could be used to create devices that might be used to monitor personal health.
    Their findings are published in the journal Proceedings of the National Academy of Sciences.
    Zheng Yan, an assistant professor in the College of Engineering, said many existing commercial on-skin biomedical devices often contain two major components -- a biomedical tracking component and a surrounding flexible material, such as plastic, to provide a supportive structure for the component to maintain an on-skin connection with a person's body.
    "The conventional approach for developing an on-skin biomedical electronic device is usually complex and often expensive to produce," he said. "In contrast, our approach is low-cost and very simple. We can make a similar device using widely available pencils and paper."
    Since its invention, pencils -- made of lead including various levels of graphite, clay and wax -- have often been used for writing and drawing. In the study, the researchers discovered that pencils containing more than 90% graphite are able to conduct a high amount of energy created from the friction between paper and pencil caused by drawing or writing. Specifically, the researchers found pencils with 93% graphite were the best for creating a variety of on-skin bioelectronic devices drawn on commercial office copy paper. Yan said a biocompatible spray-on adhesive could also be applied to the paper to help it stick better to a person's skin.
    The researchers said their discovery could have broad future applications in home-based, personalized health care, education and remote scientific research such as during the COVID-19 pandemic. Yan said the group's next step would be to further develop and test the use of the biomedical components, including electrophysiological, temperature and biochemical sensors.
    "For example, if a person has a sleep issue, we could draw a biomedical device that could help monitor that person's sleep levels," he said. "Or in the classroom, a teacher could engage students by incorporating the creation of a wearable device using pencils and paper into a lesson plan. Furthermore, this low-cost, easily customizable approach could allow scientists to conduct research at home, such as during a pandemic."
    An additional benefit to their approach, Yan said, is that paper can decompose in about a week, compared to many commercial devices that contain components that are not easily broken down.
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    The study, "Pencil-paper on-skin electronics," was published in Proceedings of the National Academy of Sciences. Other authors on the study are Yadong Xu, Ganggang Zhao, Qihui Fei, Zhe Zhang, Zanyu Chen, Yangyang Chen, Yun Ling, Shinghua Ding and Guoliang Huang at MU; Liang Zhu and Pai-Yen Chen at the University of Illinois-Chicago; Fufei An and Qing Cao at the University of Illinois Urbana-Champaign; and Peijun Guo at Yale University.
    Funding was provided by a University of Missouri start-up fund, and grants from the National Science Foundation, the Air Force Office of Scientific Research and the National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies.

    Green is more than skin-deep for hundreds of frog species

    Biochemical workaround makes pigment that tunes light to the exact shade of a green leaf
    DUKE UNIVERSITY


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    IMAGE: THE GLASS FROG ESPADARANA HAS TRANSLUCENT SKIN AND GREEN INSIDES, THANKS TO AN EVOLUTIONARY ADAPTATION THAT TURNED A TOXIC BYPRODUCT OF BLOOD BREAKDOWN INTO A LOVELY GREEN PIGMENT. EVEN ITS... view more 
    CREDIT: SANTIAGO R. RON

    DURHAM, N.C. -- Frogs and toads are green for a very good reason - it makes them harder to see in their leafy environments. Good camouflage allows them to eat and not be eaten. But not all frogs have arrived at this life-saving greenness in the same way.
    Most of these animals rely on color-controlling structures in their skin called chromatophores that use crystals to bend light to specific colors and make them appear green. But there are hundreds of species of frogs and toads that have nearly translucent skin and very few chromatophores.
    Their greenness, which can be found deep in their lymphatic fluid, soft tissues and even bones, comes from a clever biochemical workaround that combines a normally virus-fighting type of protein with a toxic byproduct of blood breakdown.
    The finding, by post-doctoral researcher Carlos Taboada at Duke University, solves a few longstanding mysteries about these frogs and shows how the necessity of survival can be very inventive indeed. It appears the week of July 13 in the Proceedings of the National Academy of Sciences.
    Scientists have long grappled with the fact that many of these frogs contain very high levels of bile pigment called biliverdin that is a byproduct of breaking apart old red blood cells. This pigment is normally considered a toxin to be filtered out in the liver and excreted as quickly as possible. But these frogs are found to carry four times as much biliverdin as even the sickest human with liver disease, and 200 times as much as their chromatophore-equipped frog cousins.
    To understand the biochemistry better, the researchers focused on one species, Boana punctata, the polka-dot treefrog of South America. From it, they isolated a protein they're calling BBS (biliverdin-binding serpin), which is part of a superfamily of protease inhibitors, the proteins that normally step in the way of viral replication and detoxify enzymes.
    When you see something green, its color really should be called 'everything but green,' because it is soaking up all the colors of incoming light except for green. The color we see is the frequency of light it does not absorb that bounces back to our eyes.
    Biliverdin by itself would appear to be somewhat greenish, as sometimes seen in an old bruise, but the researchers found that a bound serpin, BBS, stretches out biliverdin's helical shape to fine-tune its light absorbance, making it more cyan, a blue-green. Cyan, added to some other yellow pigments scattered in the skin, bounces back just the right shade of green. It also makes biliverdin less toxic as well, apparently.
    "This new protein has the same spectroscopic properties or light absorption properties as some plant pigments," said Taboada, who began the work in Argentina, Ecuador and Brazil and completed it at Duke. "The light properties are very similar to what we see, for example, in some plant proteins called phytochromes. But here we have a completely different protein."
    It's a clever adaptation of existing biochemistry that normally serves other functions in vertebrates. Taboada said this innovation has evolved more than 40 times across 11 different families, most of them treefrogs. The adaptation happened again and again in far-flung Madagascar, South America and Southeast Asia.
    "So this is a convergence in evolution," Taboada said. "Being arboreal (living in trees), they developed a different way to make their coloration." Their through-and-through greenness ensures good camouflage on foliage, even in near-infrared light.
    "This shows how natural selection can co-opt proteins for just about any purpose," said Sönke Johnsen, a professor of biology at Duke and coauthor on the paper. "Biliverdin is a bile pigment that would normally be excreted from the body because of its potential for harm, but here it is in spectacular concentrations precisely because it's also useful as a green pigment."
    "In other words, Kermit has jaundice," Johnsen said.
    Having earlier discovered that many species of frogs reflect fluorescent wavelengths - essentially glowing in the dark - Taboada is now working with engineers at Duke's Pratt School of Engineering to shine precisely tuned lasers at frogs to learn more about their coloration.
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    "This paper is a tour de force reach between the worlds of molecular biology, biochemistry, and ecology," Johnsen said.
    CITATION: "Multiple Origins of Green Coloration in Frogs Mediated by a Novel Biliverdin-Binding Serpin," Carlos Taboada, Andres E. Brunetti, Mariana L. Lyra, Robert R. Fitak, Ana Faigon, Santiago R. Ron, Maria G. Lagorio, Célio F. B. Haddad, Norberto P. Lopes, Sönke Johnsen, Julian Faivovich, Lucia B. Chemes, Sara E. Bari. Proceedings of the National Academy of Sciences, July 13, 2020. DOI: 10.1073/pnas.2006771117