Monday, October 19, 2020

 

Cannabis reduces OCD symptoms by half in the short-term

WASHINGTON STATE UNIVERSITY

Research News

PULLMAN, Wash. - People with obsessive-compulsive disorder, or OCD, report that the severity of their symptoms was reduced by about half within four hours of smoking cannabis, according to a Washington State University study.

The researchers analyzed data inputted into the Strainprint app by people who self-identified as having OCD, a condition characterized by intrusive, persistent thoughts and repetitive behaviors such as compulsively checking if a door is locked. After smoking cannabis, users with OCD reported it reduced their compulsions by 60%, intrusions, or unwanted thoughts, by 49% and anxiety by 52%.

The study, recently published in the Journal of Affective Disorders, also found that higher doses and cannabis with higher concentrations of CBD, or cannabidiol, were associated with larger reductions in compulsions.

"The results overall indicate that cannabis may have some beneficial short-term but not really long-term effects on obsessive-compulsive disorder," said Carrie Cuttler, the study's corresponding author and WSU assistant professor of psychology. "To me, the CBD findings are really promising because it is not intoxicating. This is an area of research that would really benefit from clinical trials looking at changes in compulsions, intrusions and anxiety with pure CBD."

The WSU study drew from data of more than 1,800 cannabis sessions that 87 individuals logged into the Strainprint app over 31 months. The long time period allowed the researchers to assess whether users developed tolerance to cannabis, but those effects were mixed. As people continued to use cannabis, the associated reductions in intrusions became slightly smaller suggesting they were building tolerance, but the relationship between cannabis and reductions in compulsions and anxiety remained fairly constant.

Traditional treatments for obsessive-compulsive disorder include exposure and response prevention therapy where people's irrational thoughts around their behaviors are directly challenged, and prescribing antidepressants called serotonin reuptake inhibitors to reduce symptoms. While these treatments have positive effects for many patients, they do not cure the disorder nor do they work well for every person with OCD.

"We're trying to build knowledge about the relationship of cannabis use and OCD because it's an area that is really understudied," said Dakota Mauzay, a doctoral student in Cuttler's lab and first author on the paper.

Aside from their own research, the researchers found only one other human study on the topic: a small clinical trial with 12 participants that revealed that there were reductions in OCD symptoms after cannabis use, but these were not much larger than the reductions associated with the placebo.

The WSU researchers noted that one of the limitations of their study was the inability to use a placebo control and an "expectancy effect" may play a role in the results, meaning when people expect to feel better from something they generally do. The data was also from a self-selected sample of cannabis users, and there was variability in the results which means that not everyone experienced the same reductions in symptoms after using cannabis.

However, Cuttler said this analysis of user-provided information via the Strainprint app was especially valuable because it provides a large data set and the participants were using market cannabis in their home environment, as opposed to federally grown cannabis in a lab which may affect their responses. Strainprint's app is intended to help users determine which types of cannabis work the best for them, but the company provided the WSU researchers free access to users' anonymized data for research purposes.

Cuttler said this study points out that further research, particularly clinical trials on the cannabis constituent CBD, may reveal a therapeutic potential for people with OCD.

This is the fourth study Cuttler and her colleagues have conducted examining the effects of cannabis on various mental health conditions using the data provided by the app created by the Canadian company Strainprint. Others include studies on how cannabis impacts PTSD symptoms, reduces headache pain, and affects emotional well-being.

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UMD-led study shows fear and anxiety share same bases in brain


Transformational findings could ultimately lead to better models of emotion and more effective interventions for anxiety and depression

UNIVERSITY OF MARYLAND

Research News

COLLEGE PARK, Md. - Anxiety, the most common family of mental illnesses in the U.S., has been pushed to epic new heights by the COVID-19 pandemic, with the Centers for Disease Control and Prevention estimating that nearly 1 in 3 U.S. adults and a staggering 41% of people ages 18-29 experienced clinically significant anxiety symptoms in late August. Now, the findings of a recent UMD-led study indicate that some long-accepted thinking about the basic neuroscience of anxiety is wrong.

The report by an international team of researchers led by Alexander Shackman, an associate professor of psychology at UMD, and Juyoen Hur, an assistant professor of psychology at Yonsei University in Seoul, South Korea, provides new evidence that fear and anxiety reflect overlapping brain circuits. The findings run counter to popular scientific accounts, highlighting the need for a major theoretical reckoning. The study was published last week in the Journal of Neuroscience.

"The conceptual distinction between 'fear' and 'anxiety' dates back to the time of Freud, if not the Greek philosophers of antiquity," said Shackman, a core faculty member of UMD's Neuroscience and Cognitive Science Program, and 2018 recipient of a seed grant award from UMD's Brain and Behavior Initiative, "In recent years, brain imagers and clinicians have extended this distinction, arguing that fear and anxiety are orchestrated by distinct neural networks.

However, Shackman says their new study adds to a rapidly growing body of new evidence suggesting that this old mode is wrong. "If anything, fear and anxiety seem to be constructed in the brain using a massively overlapping set of neural building blocks," he said.

Prevailing scientific theory holds that fear and anxiety are distinct, with different triggers and strictly segregated brain circuits. Fear--a fleeting reaction to certain danger--is thought to be controlled by the amygdala, a small almond-shaped region buried beneath the wrinkled convolutions of the cerebral cortex. By contrast, anxiety--a persistent state of heightened apprehension and arousal elicited when threat is uncertain--is thought to be orchestrated by the neighboring bed nucleus of the stria terminalis (BNST). But new evidence from Shackman and his colleagues suggests that both of these brain regions are equally sensitive to certain and uncertain kinds of threats.

Leveraging cutting-edge neuroimaging techniques available at the Maryland Neuroimaging Center, their research team used fMRI to quantify neural activity while participants anticipated receiving a painful shock paired with an unpleasant image and sound--a new task that the researchers dubbed the "Maryland Threat Countdown".

The timing of this "threat" was signaled either by a conventional countdown timer--i.e. "3, 2, 1..."--or by a random string of numbers--e.g. "16, 21, 8." In both conditions, threat anticipation recruited a remarkably similar network of brain regions, including the amygdala and the BNST. Across a range of head-to-head comparisons, the two showed statistically indistinguishable responses.

The team examined the neural circuits engaged while waiting for certain and uncertain threat (i.e. "fear" and "anxiety"). Results demonstrated that both kinds of threat anticipation recruited a common network of core brain regions, including the amygdala and BNST.

These observations raise important questions about the Research Domain Criteria (RDoC) framework that currently guides the U.S. National Institute of Mental Health's quest to discover the brain circuitry underlying anxiety disorders, depression, and other common mental illnesses. "As it is currently written, RDoC embodies the idea that certain and uncertain threat are processed by circuits centered on the amygdala and BNST, respectively. It's very black-and-white thinking," Shackman noted, emphasizing that RDoC's "strict-segregation" model is based on data collected at the turn of the century.

"It's time to update the RDoC so that it reflects the actual state of the science. It's not just our study; in fact, a whole slew of mechanistic studies in rodents and monkeys, and new meta-analyses of the published human imaging literature are all coalescing around the same fundamental scientific lesson: certain and uncertain threat are processed by a shared network of brain regions, a common core," he said.

As the crown jewel of NIMH's strategic plan for psychiatric research in the U.S., the RDoC framework influences a wide range of biomedical stakeholders, from researchers and drug companies to private philanthropic foundations and foreign funding agencies. Shackman noted that the RDoC has an outsized impact on how fear and anxiety research is designed, interpreted, peer reviewed, and funded here in the U.S. and abroad.

"Anxiety disorders impose a substantial and growing burden on global public health and the economy," Shackman said, "While we have made tremendous scientific progress, existing treatments are far from curative for many patients. Our hope is that research like this study can help set the stage for better models of emotion and, ultimately, hasten the development of more effective intervention strategies for the many millions of children and adults around the world who struggle with debilitating anxiety and depression."

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This work was supported by the National Institute of Mental Health and University of Maryland, College Park.

The research team also included Allegra S. Anderson, Vanderbilt University; Jinyi Kuang, University of Pennsylvania; Manuel Kuhn, Harvard Medical School; Andrew S. Fox, University of California, Davis; and Jason F. Smith, Rachael M. Tillman, Hyung Cho Kim, and Kathryn A. DeYoung, all from the University of Maryland, College Park.

 

Driver of the largest mass extinction in the history of the Earth identified

New study provides a comprehensive reconstruction of the Permian-Triassic boundary event

HELMHOLTZ CENTRE FOR OCEAN RESEARCH KIEL (GEOMAR)

Research News

Life on Earth has a long, but also an extremely turbulent history. On more than one occasion, the majority of all species became extinct and an already highly developed biodiversity shrank to a minimum again, changing the course of evolution each time. The most extensive mass extinction took place about 252 million years ago. It marked the end of the Permian Epoch and the beginning of the Triassic Epoch. About three quarters of all land life and about 95 percent of life in the ocean disappeared within a few thousands of years only.

Gigantic volcanic activities in today's Siberia and the release of large amounts of methane from the sea floor have been long debated as potential triggers of the Permian-Triassic extinction. But the exact cause and the sequence of events that led to the mass extinction remained highly controversial. Now, scientists from Germany, Italy and Canada, in the framework of the EU-funded project BASE-LiNE Earth led by Prof. Dr. Anton Eisenhauer from GEOMAR Helmholtz Centre for Ocean Research Kiel in cooperation with the Helmholtz Centre Potsdam GFZ German Research Centre for Geosciences, have for the first time been able to conclusively reconstruct the entire cascade of events at that time using cutting-edge analytical techniques and innovative geochemical modelling. The study has been published today in the international journal Nature Geoscience.

For their study, the BASE-LiNE Earth team used a previously often neglected environmental archive: the shells of fossil brachiopods. "These are clam-like organisms that have existed on Earth for more than 500 million years. We were able to use well-preserved brachiopod fossils from the Southern Alps for our analyses. These shells were deposited at the bottom of the shallow shelf seas of the Tethys Ocean 252 million years ago and recorded the environmental conditions shortly before and at the beginning of extinction", explains Dr. Hana Jurikova. She is first author of the study, which she conducted as part of the BASE-LiNE Earth project and her doctoral thesis at GEOMAR.

By measuring different isotopes of the element boron in the fossil shells, the team was able to trace the development of the pH values in the ocean 252 million years ago. Since seawater pH is tightly coupled to the CO2 concentration in the atmosphere, the reconstruction of the latter was also possible. For the analyses, the team used high-precision isotope analyses at GEOMAR as well as high-resolution microanalyses on the state-of-the-art large-geometry secondary ion mass spectrometer (SIMS) at GFZ.

"With this technique, we can not only reconstruct the evolution of the atmospheric CO2 concentrations, but also clearly trace it back to volcanic activity. The dissolution of methane hydrates, which had been suggested as a potential further cause, is highly unlikely based on our data", explains Dr. Marcus Gutjahr from GEOMAR, co-author of the study.

As a next step, the team fed their data from the boron and additional carbon isotope-based investigations into a computer-based geochemical model that simulated the Earth's processes at that time. Results showed that warming and ocean acidification associated with the immense volcanic CO2 injection to the atmosphere was already fatal and led to the extinction of marine calcifying organisms right at the onset of the extinction. However, the CO2 release also brought further consequences; with increased global temperatures caused by the greenhouse effect, chemical weathering on land also increased.

Over thousands of years, increasing amounts of nutrients reached the oceans via rivers and coasts, which then became over-fertilized. The result was a large-scale oxygen depletion and the alteration of entire elemental cycles. "This domino-like collapse of the inter-connected life-sustaining cycles and processes ultimately led to the observed catastrophic extent of mass extinction at the Permian-Triassic boundary," summarizes Dr. Jurikova.

The study was conducted within the framework of the EU-funded ITN project BASE-LiNE Earth, in which the use of brachiopods as an environmental archive was systematically studied for the first time, and relevant analytical methods were improved and newly developed. "Without these new techniques it would be difficult to reconstruct environmental processes more than 250 million years ago in the same level of detail as we have done now", emphasizes Prof. Dr. Anton Eisenhauer from GEOMAR, the former BASE-LiNE Earth project coordinator and co-author of the new study, "in addition, the new methods can be applied for other scientific applications".

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LSU Health New Orleans review suggests HNB tobacco products may threaten health

LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER

Research News

New Orleans, LA - A review of heat-not-burn (HNB) tobacco products from the laboratory of Dr. Jason Gardner, Professor of Physiology at LSU Health New Orleans School of Medicine, reports an association with elevated blood pressure, increased heart rate, cell death, and circulatory dysfunction shown by early studies. Additionally, chemicals found in the vapor produced by HNB devices have previously been shown to impair lung function, put users at risk of heart attack and stroke, cause cancers, increase circulating low-density lipoprotein ("bad cholesterol") and more. The review is published in the American Journal of Physiology-Heart and Circulatory Physiology, available online here.

Cigarette smoking continues to decline globally, but vaping is becoming more popular, especially among youth and young adults. Recent cases of vaping-associated lung injury may lead consumers to try new methods of nicotine consumption. Heat-not-burn products are newcomers to the U.S. market. They produce nicotine-containing vapor by heating tobacco at low temperatures. This is in contrast to cigarettes that use high temperatures to burn tobacco and produce smoke or e-cigarettes that heat e-liquid, which contains nicotine but not tobacco, to produce vapor.

Due to the novelty of these products, little research has been conducted on HNB devices. The Gardner lab compiled findings from dozens of human, animal, and cell culture studies to determine associated inhalants and potential health effects, with an emphasis on the heart, arteries, and veins. Findings suggest that HNB devices produce fewer pollutants than cigarettes, but it is unclear if these reductions are reflected in health outcomes of users.

"While relatively new to the U.S., heat-not-burn products have become popular in other countries including Japan, Italy, and Korea," notes lead author Nicholas Fried, an MD/PhD student in Dr. Gardner's laboratory. "These products are often touted as a replacement for cigarettes, but the evidence does not necessarily support that. Almost all Korean users of heat-not-burn products are also current cigarette smokers; nearly half of Italian users had never even smoked a cigarette. These trends worryingly suggest that heat-not-burn may be a compliment or gateway to cigarette smoking, rather than a 'healthy' replacement. More troubling, nearly 2% of high school students in the U.S. are already using HNB tobacco products, and surveys show that 25% of students are susceptible to trying them. There is potential for these devices to become a significant public health issue."

Dr. Gardner adds, "Heat-not-burn devices are marketed as a safer alternative to cigarettes for existing smokers. However, as we have learned from vaping and e-cigarettes, these products are very likely to be used by minors and never-smokers due to marketing, flavor options, and lack of social stigma that is found with traditional cigarettes."

The authors conclude, "Use of these products can lead to nicotine addiction and additional clinical, basic science, and epidemiological studies are needed to better understand the health effects of HNB products. This knowledge will assist consumers, physicians, lawmakers, and regulatory bodies in making informed decisions about these products."

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The authors are supported by a grant from the National Heart, Lung, and Blood Institute of the National Institutes of Health.

LSU Health Sciences Center New Orleans educates Louisiana's health care professionals. The state's flagship health sciences university, LSU Health New Orleans includes a School of Medicine with branch campuses in Baton Rouge and Lafayette, the state's only School of Dentistry, Louisiana's only public School of Public Health, and Schools of Allied Health Professions, Nursing, and Graduate Studies. LSU Health New Orleans faculty take care of patients in public and private hospitals and clinics throughout the region. In the vanguard of biosciences research in a number of areas in a worldwide arena, the LSU Health New Orleans research enterprise generates jobs and enormous economic impact. LSU Health New Orleans faculty have made lifesaving discoveries and continue to work to prevent, advance treatment, or cure disease. To learn more, visit http://www.lsuhsc.eduhttp://www.twitter.com/LSUHealthNO, or http://www.facebook.com/LSUHSC.

 

Biochar helps hold water, saves money

Rice study shows sandy soils benefit most by retaining water, cutting irrigation needs

RICE UNIVERSITY

Research News

IMAGE

IMAGE: A MAP SHOWS LOW, MID-RANGE AND HIGH ESTIMATES FOR THEORETICAL WATER-HOLDING CAPACITY CHANGES IN SOIL WITH THE ADDITION OF BIOCHAR. A STUDY BY RICE UNIVERSITY SCIENTISTS SHOWED HOW BIOCHAR CAN... view more 

CREDIT: MASIELLO LAB/RICE UNIVERSITY

HOUSTON - (Oct. 19, 2020) - The abstract benefits of biochar for long-term storage of carbon and nitrogen on American farms are clear, and now new research from Rice University shows a short-term, concrete bonus for farmers as well.

That would be money. To be precise, money not spent on irrigation.

In the best-case scenarios for some regions, extensive use of biochar could save farmers a little more than 50% of the water they now use to grow crops. That represents a significant immediate savings to go with the established environmental benefits of biochar.

The open-access study appears in the journal GCB-Bioenergy.

Biochar is basically charcoal produced through pyrolysis, the high-temperature decomposition of biomass, including straw, wood, shells, grass and other materials. It has been the subject of extensive study at Rice and elsewhere as the agriculture industry seeks ways to enhance productivity, sequester carbon and preserve soil.

The new model built by Rice researchers explores a different benefit, using less water.

"There's a lot of biochar research that focuses mostly on its carbon benefits, but there's fairly little on how it could help stakeholders on a more commercial level," said lead author and Rice alumna Jennifer Kroeger, now a fellow at the Science and Technology Policy Institute in Washington, D.C. "It's still an emerging field."

The study co-led by Rice biogeochemist Caroline Masiello and economist Kenneth Medlock provides formulas to help farmers estimate irrigation cost savings from increased water-holding capacity (WHC) with biochar amendment.

The researchers used their formulas to reveal that regions of the country with sandy soils would see the most benefit, and thus the most potential irrigation savings, with biochar amendment, areas primarily in the southeast, far north, northeast and western United States.

The study analyzes the relationship between biochar properties, application rates and changes in WHC for various soils detailed in 16 existing studies to judge their ability to curtail irrigation.

The researchers defined WHC as the amount of water that remains after allowing saturated soil to drain for a set period, typically 30 minutes. Clay soils have a higher WHC than sandy soils, but sandy soils combined with biochar open more pore space for water, making them more efficient.

WHC is also determined by pore space in the biochar particles themselves, with the best results from grassy feedstocks, according to their analysis.

In one comprehensively studied plot of sandy soil operated by the University of Nebraska-Lincoln's Agricultural Water Management Network, Kroeger calculated a specific water savings of 37.9% for soil amended with biochar. Her figures included average rainfall and irrigation levels for the summer of 2019.

The researchers noted that lab experiments typically pack more biochar into a soil sample than would be used in the field, so farmers' results may vary. But they hope their formula will be a worthy guide to those looking to structure future research or maximize their use of biochar.

More comprehensive data for clay soils, along with better characterization of a range of biochar types, will help the researchers build models for use in other parts of the country, they wrote.

"This study draws attention to the value of biochar amendment especially in sandy soils, but it's important to note that the reason we are calling out sandy soils here is because of a lack of data on finer-textured soils," Masiello said. "It's possible that there are also significant financial benefits on other soil types as well; the data just weren't available to constrain our model under those conditions."

"Nature-based solutions are gaining traction at federal, state and international levels," Medlock added, noting the recently introduced Growing Climate Solutions Act as one example. "Biochar soil amendment can enhance soil carbon sequestration while providing significant co-benefits, such as nitrogen remediation, improved water retention and higher agricultural productivity. The suite of potential benefits raises the attractiveness for commercial action in the agriculture sector as well as supportive policy frameworks."



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Rice alumna Ghasideh Pourhashem, a nonresident faculty scholar at the Center for Energy Studies (CES) at Rice's Baker Institute for Public Policy, is co-author of the paper. Masiello is the W. Maurice Ewing Professor, a professor of Earth, environmental and planetary sciences and a faculty scholar at the CES. Medlock is the James A. Baker, III, and Susan G. Baker Fellow in Energy and Resource Economics at the Baker Institute, senior director of the CES and an adjunct assistant professor of economics.

The Rice Department of Earth, Environmental and Planetary Sciences and the Rice Shell Center for Sustainability supported the research.

Read the study at https://onlinelibrary.wiley.com/doi/10.1111/gcbb.12765.

This news release can be found online at https://news.rice.edu/2020/10/19/biochar-helps-hold-water-saves-money/

Follow Rice News and Media Relations via Twitter @RiceUNews.

Related materials:

Feds, states can help biochar live up to its soil-saving potential: http://news.rice.edu/2019/01/11/feds-states-can-help-biochar-live-up-to-its-soil-saving-potential-2/

Biochar could clear the air in more ways than one: http://news.rice.edu/2017/07/26/biochar-could-clear-the-air-in-more-ways-than-one/

Study: Biochar alters water flow to improve sand and clay: http://news.rice.edu/2014/09/24/study-biochar-alters-water-flow-to-improve-sand-and-clay/

Biochar quiets microbes, including some plant pathogens: http://news.rice.edu/2013/09/30/biochar-quiets-microbes-including-some-plant-pathogens/

Masiello Lab: https://www.masiellolab.org

Kenneth Medlock: https://www.bakerinstitute.org/experts/kenneth-b-medlock-iii/

Rice Department of Earth, Environmental and Planetary Sciences: https://earthscience.rice.edu

Wiess School of Natural Sciences: https://naturalsciences.rice.edu

Images for download:

https://news-network.rice.edu/news/files/2020/10/1019_BIOCHAR-1-WEB.jpg

Biochar's benefits for the long-term sequestration of carbon and nitrogen on American farms are clear, but new research from Rice University shows it can help farmers save money on irrigation as well. The study showed that sandy soil, in particular, gains ability to retain more water when amended with biochar. (Credit: Masiello Lab/Rice University)

https://news-network.rice.edu/news/files/2020/10/1019_BIOCHAR-2a-WEB.jpg

A map shows low, mid-range and high estimates for theoretical water-holding capacity changes in soil with the addition of biochar. A study by Rice University scientists showed how biochar can help curtail excess irrigation in agriculture, depending on the type of soil and biochar characteristics. (Credit: Masiello Lab/Rice University)

https://news-network.rice.edu/news/files/2020/10/1019_BIOCHAR-3-WEB-1.jpg

Rice University alumna Jennifer Kroeger led a study that shows how America's farmers could save money on irrigation through the use of biochar. (Credit: Courtesy of Jennifer Kroeger/Rice University)

Located on a 300-acre forested campus in Houston, Rice University is consistently ranked among the nation's top 20 universities by U.S. News & World Report. Rice has highly respected schools of Architecture, Business, Continuing Studies, Engineering, Humanities, Music, Natural Sciences and Social Sciences and is home to the Baker Institute for Public Policy. With 3,978 undergraduates and 3,192 graduate students, Rice's undergraduate student-to-faculty ratio is just under 6-to-1. Its residential college system builds close-knit communities and lifelong friendships, just one reason why Rice is ranked No. 1 for lots of race/class interaction and No. 1 for quality of life by the Princeton Review. 

LISTERIA

American Frozen Food Institute's international expert panel publishes new manuscript

AMERICAN FROZEN FOOD INSTITUTE

Research News

Arlington, VA - The American Frozen Food Institute (AFFI) announces the publication of a new manuscript, "Alternative Approaches to the Risk Management of Listeria monocytogenes in Low Risk Foods," now available online in Food Control, an international scientific journal for food safety and process control professionals.

The manuscript represents the proceedings and recommendations of AFFI's Listeria monocytogenes (Lm) International Expert Panel, comprised of eminent researchers in Listeria science, epidemiology, risk modeling, food microbiology, and regulatory and public health policy. AFFI assembled the expert panel in December 2018 as part of its efforts to merge available Lm research and data with the most recent scientific thinking on regulatory policies governing the prevalence of Lm in foods. The panel set out with the objective to develop a scientific basis and rationale for Lm regulatory policies.

"The frozen food industry is committed to advancing food safety practices to prevent and control Listeria monocytogenes," said AFFI President and CEO Alison Bodor. "We're grateful for the insights and guidance from the Lm International Expert Panel and believe their new recommendations should guide practical and sustained approaches to Listeria regulatory policy that improve public health."

Key elements of the manuscript include discussions on:

  • The importance of using risk-based approaches to regulate the presence of Lm across the broad category of ready-to-eat foods.
  • The benefits of policies that acknowledge the ubiquity of Lm and encourage finding and destroying, controlling cross contamination and preventing growth of the pathogen.
  • A framework to facilitate further reduction of public health impact relative to Lm by expending limited resources (aLmost solely) on high-risk foods.
  • Establishing a regulatory action level for low-risk foods, particularly where foods do not support growth of Lm.
  • Alternate sampling and testing protocols to address Lm risk.
  • Effective testing by industry of low-risk foods to better protect public health.

This latest publication furthers AFFI's commitment to raising the bar on food safety practices to help prevent and control Lm. AFFI has undertaken numerous efforts to advance understanding of Lm through scientific research, innovation, education and training, including launching the AFFI Food Safety Zone.

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About AFFI

The American Frozen Food Institute (AFFI) is the member-driven national trade association that advances the interests of all segments of the frozen food and beverage industry. AFFI works to advance food safety and advocates before legislative and regulatory entities on the industry's behalf to create an environment where members' foods and beverages are proudly chosen to meet the needs of a changing world.

 

Natural disaster preparations may aid businesses' pandemic response

NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY (NIST)

Research News

The social and economic impacts of COVID-19 have battered small- and medium-sized enterprises, putting millions of jobs in the U.S. at risk. And a year rife with natural disasters has not done many struggling businesses any favors.

To learn about the strategies and experiences of businesses managing this double threat, researchers at the National Institute of Standards and Technology (NIST), in collaboration with the National Oceanic and Atmospheric Administration (NOAA), surveyed small- and medium-sized enterprises across the country. In a new report of survey results, nearly a quarter of businesses felt natural disaster preparations helped them address COVID-19. They tended to find preparations of broad applicability during natural disasters, such as telework readiness, more useful than hazard-specific measures. The survey also identified areas of hardship for businesses, including uncertainty and a lack of guidance and resources.

"The survey results can help by drawing attention to how small- and medium-sized businesses are thriving or suffering and showing where natural disaster planning and preparation helped," said Ariela Zycherman, NOAA social scientist and co-author of the report. "The results will also help us identify places where there are needs and opportunities to build social and economic resilience to multiple types of disasters."

The NIST and NOAA researchers conducted the survey from July 8 to Aug. 8, reaching businesses with fewer than 10 to more than 100 employees from a wide array of industries, including construction, manufacturing and retail. With help from other entities, such as the Minority Business Development Agency and the Small Business Administration, the authors promoted the survey via email, newsletter and social media, obtaining more than 1,300 responses.

In the survey, the team asked businesses about challenges presented by COVID-19 and measures taken to manage them. The researchers also inquired about experiences with sudden, high-impact disasters, such as hurricanes, earthquakes and wildfires, as well as longer-lasting, slower-onset events, including droughts and winter storms.

Twenty-nine percent of respondents said they had experienced natural disasters since March 13, when the federal government declared the pandemic a national emergency. The researchers expect this figure would be much higher had the survey been distributed later, however, as events such as the wildfires along the West Coast surged after the survey closed.

Some 24% of survey respondents said experience preparing for natural disasters in the past helped them during the COVID-19 pandemic. Through the survey's open-ended responses, the researchers were able to glean insights into which types of preparation businesses found most beneficial.

Practices with broad applicability shone through over those specific to one kind of disaster. Two notable examples from the responses were having rainy-day funds for when income streams dry up and the ability to operate a business remotely, said Jennifer Helgeson, a NIST research economist and lead author of the report.

One respondent wrote, "We have dealt with many weather emergencies in the past as well [as] a bad flu pandemic, all of which prepared us for something like COVID-19, especially as it relates to teleworking. Our employees have been used to teleworking during emergencies."

Many businesses have not made a smooth transition, however. Smaller operations that rely on in-person customers, such as in the service industry, face a particularly grave threat in COVID-19, which has eaten away at customer bases for lengths of time these businesses were not prepared for.

The outlook for many of the surveyed businesses is currently worrisome, as 72% are concerned about heading into another distressing scenario on top of the pandemic. Almost a third of these businesses are wary of natural disasters specifically. A strong sense of uncertainty also looms over numerous businesses -- a sense that may be compounded by a lack of resources, a situation reported by 37% of respondents.

The researchers found that businesses are commonly struggling to obtain guidance on prioritizing their actions amid the strains of the pandemic, personal protective equipment, and training on how to receive support from financial institutions and lending personnel.

A large portion of businesses anticipate that they are in for the long haul before returning to pre-COVID operating capacity. While 39% said they believe recovery will take less than 18 months, 23% estimate the process will go on for longer. And nearly a fifth of respondents indicated full recovery as an unlikely outcome, no matter the time frame, with many indicating they are now considering early retirement.

The researchers plan to complement the data from this initial report by distributing another survey in the winter to both previously contacted and new businesses. With a second wave, the team plans to collect information about how businesses operating in a pandemic respond to events expected in the near future, including winter storms and the flu season, Helgeson said. Further study might also identify where and how businesses are currently receiving aid.

"I do think there will be more of a focus on understanding if there are certain attributes of the business, whether it be employee size or ownership demographics, that can correlate loosely with the kinds of support they've received or the places they're asking for support," Helgeson said. "Is it more about friends and family or is it more about small-business loans? And how might this change if they experience a natural disaster during the pandemic?"

For agencies and institutions committed to supporting small- and medium-sized enterprises for resilience planning and adaptation, the data from this and any subsequent reports could enhance strategies to reach vulnerable populations and deliver some certainty during a deeply uncertain time.

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View the report for more survey results. If you would like to participate in the second survey, please contact SMEResearch@nist.gov.

Food waste: cities can make the difference

CMCC FOUNDATION - EURO-MEDITERRANEAN CENTER ON CLIMATE CHANGE

Research News

IMAGE

IMAGE: APPLICATION OF THE FRAMEWORK TO THE ANALYSIS OF THE 40 EUROPEAN LEADING CITIES IN URBAN FOOD WASTE INITIATIVES. THE THREE HORIZONTAL AXES REPRESENT THE THREE PILLARS OF THE FRAMEWORK AND... view more 

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Food waste is one of the most important issues of current food systems: Food and Agriculture Organization (FAO) has estimated that more than one third of food is either lost or wasted along the entire food supply chain causing significant economic, social and environmental impacts.

From an environmental point of view, food waste represents between 8% and 10% of global greenhouse gas emissions, and the annual water footprint of the agricultural phase of food waste is about 250 km3, five times the volume of Lake Garda and higher than any national food consumption water footprint. The IPCC Special Report Climate Change and Land (2018) estimates that 37% of total greenhouse gas (GHG) emissions are attributable to the food system considering its complete cycle, from agriculture and land use, storage, transport, packaging, processing, retail, consumption and waste. In the European Union (EU), 88 million tons of food waste are generated each year (i.e., 173 kg per capita) with significant economic, environmental and social impacts. It has been estimated that 15-16% of the total environmental impact of the food supply chain in Europe can be attributed to food waste.

Cities have emerged as crucial actors in the global food security geography: today they occupy approximately only 3% of the total land, but the number of people living in urban areas surpassed for the first time the number of people living in rural areas, and urban contexts are therefore the biggest source of post-consumption food waste, using between 70% and 80% of world's food.

However, cities have proved to be crucial actors in tackling food waste, launching effective policies and initiatives to address it.

By looking at 40 cities across 16 European countries, a study recently published on Resources - Special issue Food Loss and Waste: The Challenge of a Sustainable Management through a Circular Economy Perspective presented a new framework for assessing urban food waste policies and initiatives.

"Food loss and waste is recognized as one of the most challenging distortion of current food system", explains Marta Antonelli, senior scientist at the CMCC Foundation and Head of Research at Barilla Foundation. "We talk about distortion because we produce tons of edible food waste every year. Food loss occurs from farm up to and excluding retail, whilst food waste occurs at retail, food service and household level. Causes range from poor handling, inadequate transport or storage, lack of cold chain capacity, extreme weather conditions to cosmetic standards, and a lack of planning and cooking skills among consumers. This year we have witnessed an increase in food loss and waste as a result of movement and transport restrictions due to the pandemic. COVID-19 aside, each year about 14% of the world's food is lost before even reaching the market."

Reducing food lost or wasted means more food for all, less greenhouse gas emissions, less pressure on environment, especially on water and land resources, increased productivity and economic growth, and more sustainable societies.

"Food waste management is a very complex challenge" explains Marta Antonelli, "since it requires diversified but integrated actions that involve many public local authorities, such as cities, regions, metropolitan areas and provinces, and other actors including retailers, school canteens, hospitals, food markets, citizens and non-governmental organizations. All these actors and levels of governance need to work in a synergic way to ensure effective urban food waste policies.

Cities can have a crucial role acting on different sectors and levels of the urban food system. The City of Milan, for example, approved a waste tax deduction for actors that contribute to reducing food waste through donations. In particular, the City of Milan has explicitly declared its ambition to halve food waste by 2030 and its intention to adopt a food supply chain approach, in order to reduce food waste across all tiers of the chain from food production to final consumption."?The authors started from a review of the most recent literature on food waste policy assessment frameworks and on urban food waste initiatives to capture the specificities of urban contexts and identify the most interesting urban initiatives and policies implemented. Finally, they identified direct and indirect links with the Sustainable Development Goals (SDGs), showing the role that cities can play in achieving the targets of the UN 2030 Agenda. The framework proposed identifies and sheds light on the links between the different types of policies launched (information based, market based, regulatory, nudging initiatives, etc), the main areas of interventions addressed, as well as the different actors intervening in urban food waste management.

The analysis highlighted that several urban food waste policies or initiatives (e.g. in Bari, Bologna, Milan, Turin, Genoa, Venice and Cremona, with public as well as and private initiatives) proved to be effective in tackling poverty and socio-economic exclusion through food donations and, also, through the creation of new job opportunities for some marginalised groups of the population.

"Tackling food waste can be a key component of wider initiatives based on integrated management of the urban challenges and that promote the collaboration and coordination of the urban ecosystem", Marta Antonelli adds. "If we look at urban food waste interventions, we have very few cases of integrated, multi-sectorial and multi-actorial management of food waste. Cities are currently promoting new models of governance, for instance launching new institutional settings like the Food Policy Councils, creating regional and global networks of mayors advocating for more sustainable food systems, and coordinating initiatives to address food waste-related challenges in an integrated manner, from food production to food distribution."

The study undermines the importance of providing city officials with effective tools to collect data on urban food waste levels, to understand the scope of the problem and design action. Gap in metrics and data are still many. Concrete metrics and publicly available quantification tools developed at city level are currently still missing.

"Moreover, it is essential that urban food waste policies and interventions are fully aligned with the targets of the Agenda 2030", Dr. Marta Antonelli concludes. "Only in four cases (Cremona, Liège, Milan and Montpellier), food waste interventions were explicitly put in relation with the SDGs. The research showed that cities seldom use the SDGs as a policy framework, thus limiting the evaluation of the impact of these interventions on the sustainability agenda.

Therefore, it is important to raise more awareness among local policy makers, public officials, the private sector, and citizens to fully monitor the link and the impact of food waste on the SDGs. Cities are implementing many urban food waste initiatives, but what it's still rare is an integrated vision in addressing these issues In this sense, the recently adopted 'Farm to Fork' Strategy, part of the broader objective of making the EU food system the global standard for sustainability, represents the first step of the European Commission to address food system-related challenges in an integrated manner, for example putting human health and sustainability on the same level."

The analysis could be easily expanded and replicated to other contexts, and in the future, the same framework could be valuable for other non-European cities that are starting to tackle food waste and are addressing similar challenges.

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Read the full paper:

Urban Food Waste: A Framework to Analyse Policies and Initiatives

Fattibene D., Recanati F., Dembska K., Antonelli M., 2020, Resources - Special Issue Food Loss and Waste: The Challenge of a Sustainable Management through a Circular Economy Perspective 9(9), 99; https://doi.org/10.3390/resources9090099

 Significant link found between air pollution and neurological disorders

Air pollution was significantly associated with an increased risk of hospital admissions for several neurological disorders, including Parkinson's disease, Alzheimer's disease, and other dementias, in a large, long-term study of US adults

HARVARD T.H. CHAN SCHOOL OF PUBLIC HEALTH

Research News

Boston, MA - Air pollution was significantly associated with an increased risk of hospital admissions for several neurological disorders, including Parkinson's disease, Alzheimer's disease, and other dementias, in a long-term study of more than 63 million older U.S. adults, led by researchers at Harvard T.H. Chan School of Public Health.

The study, conducted with colleagues at Emory University's Rollins School of Public Health and Columbia University's Mailman School of Public Health, is the first nationwide analysis of the link between fine particulate (PM2.5) pollution and neurodegenerative diseases in the U.S. The researchers leveraged an unparalleled amount of data compared to any previous study of air pollution and neurological disorders.

The study will be published online October 19, 2020 in The Lancet Planetary Health.

"The 2020 report of the Lancet Commission on dementia prevention, intervention, and care has added air pollution as one of the modifiable risk factors for these outcomes," said Xiao Wu, doctoral student in biostatistics at Harvard Chan School and co-lead author of the study. "Our study builds on the small but emerging evidence base indicating that long-term PM2.5 exposures are linked to an increased risk of neurological health deterioration, even at PM2.5 concentrations well below the current national standards."

Researchers looked at 17 years' worth (2000-2016) of hospital admissions data from 63,038,019 Medicare recipients in the U.S. and linked these with estimated PM2.5 concentrations by zip code. Taking into account potential confounding factors like socioeconomic status, they found that, for each 5 microgram per cubic meter of air (μg/m3) increase in annual PM2.5 concentrations, there was a 13% increased risk for first-time hospital admissions both for Parkinson's disease and for Alzheimer's disease and related dementias. This risk remained elevated even below supposedly safe levels of PM2.5 exposure, which, according to current U.S. Environmental Protection Agency standards, is an annual average of 12 μg/m3 or less.

Women, white people, and urban populations were particularly susceptible, the study found. The highest risk for first-time Parkinson's disease hospital admissions was among older adults in the northeastern U.S. For first-time Alzheimer's disease and related dementias hospital admissions, older adults in the Midwest faced the highest risk.

"Our U.S.-wide study shows that the current standards are not protecting the aging American population enough, highlighting the need for stricter standards and policies that help further reduce PM2.5 concentrations and improve air quality overall," said Antonella Zanobetti, principal research scientist in Harvard Chan School's Department of Environmental Health and co-senior author of the study.

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Liuhua Shi, research assistant professor at Emory's Rollins School of Public Health, was a co-lead author and Marianthi-Anna Kioumourtzoglou, assistant professor in environmental health sciences at Columbia's Mailman School of Public Health, was a co-senior author.

Other Harvard Chan School authors included Mahdieh Danesh Yazdi, Danielle Braun, Yaguang Wei, Yun Wang, Joel Schwartz, and Francesca Dominici.

This study was supported by the Health Effects Institute (4953-RFA14-3/16-4), the National Institute of Environmental Health Sciences (NIEHS R01 ES024332, R01 ES028805, R21 ES028472, P30 ES009089, P30 ES000002), the National Institute on Aging (NIA/NIH R01 AG066793-01, P50 AG025688), and the HERCULES Center (P30ES019776). Research described in this article was done under contract to the Health Effects Institute, an organization jointly funded by the U.S. Environmental Protection Agency (assistance award number R-83467701) and some motor vehicle and engine manufacturers.

"Long-term effects of PM2.5 on neurological disorders in the American Medicare population: a longitudinal cohort study," Liuhua Shi, Xiao Wu, Mahdieh Danesh Yazdi, Danielle Braun, Yara Abu Awad, Yaguang Wei, Pengfei Liu, Qian Di, Yun Wang, Joel Schwartz, Francesca Dominici, Marianthi-Anna Kioumourtzoglou, Antonella Zanobetti, The Lancet Planetary Health, online October 19, 2020, doi: https://doi.org/10.1016/S2542-5196(20)30227-8

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Harvard T.H. Chan School of Public Health brings together dedicated experts from many disciplines to educate new generations of global health leaders and produce powerful ideas that improve the lives and health of people everywhere. As a community of leading scientists, educators, and students, we work together to take innovative ideas from the laboratory to people's lives--not only making scientific breakthroughs, but also working to change individual behaviors, public policies, and health care practices. Each year, more than 400 faculty members at Harvard Chan School teach 1,000-plus full-time students from around the world and train thousands more through online and executive education courses. Founded in 1913 as the Harvard-MIT School of Health Officers, the School is recognized as America's oldest professional training program in public health.