Thursday, November 19, 2020

 

Denmark trial measures effectiveness of adding a mask recommendation to other public health measures

Embargoed news from Annals of Internal Medicine

AMERICAN COLLEGE OF PHYSICIANS

Research News

Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf of the organization they represent.


Denmark trial measures effectiveness of adding a mask recommendation to other public health measures for preventing SARS-CoV-2 infection

HD video soundbites of the authors and Annals editors discussing the findings are available to download at http://www.dssimon.com/MM/ACP-danmask.
Abstract: https://www.acpjournals.org/doi/10.7326/M20-6817
Editorial: https://www.acpjournals.org/doi/10.7326/M20-7448
Editorial: https://www.acpjournals.org/doi/10.7326/M20-7499


URLs are live when the embargo lifts

A randomized trial of more than 6,000 participants in Denmark adds new evidence to what is known about whether masks protect the wearer from SARS-CoV-2 infection in a setting where public health measures, including social distancing, are in effect but others are not wearing masks. The DANMASK-19 trial randomized participants to follow those public health measures with or without an additional recommendation to wear a surgical mask when outside the home. Mask use outside of hospitals was uncommon in Denmark at the time. After 1 month of follow-up, 1.8% of participants in the mask group and 2.1% in the control group developed infection. While the evidence excludes a large personal protective effect of mask wearing, it weakly supports lesser degrees of protection, and cannot definitively exclude no effect. The findings are published in Annals of Internal Medicine.

Researchers from Copenhagen University Hospital recruited 6,024 adults who spent at least 3 hours per day outside their homes, whose occupations did not require masks, and who did not have a previous known diagnosis of SARS-CoV-2 infection. Participants were randomized into the mask group or the control group and those in the mask group were given a supply of surgical masks. All participants completed weekly surveys and antibody tests with PCR testing if COVID-19 symptoms developed, and at 1 month. At the conclusion of the trial, infection rates were similar between the two groups.

Of note, Danish authorities did not recommend masks during the study period and their use in the community was uncommon. Public transportation and shops remained open and recommended public health measures included quarantine of persons with SARS-CoV-2 infection, social distancing, limiting the number of people seen, frequent hand hygiene and cleaning, and limited visitors to hospitals and nursing homes.

According to the study authors, their findings offer evidence about the degree of protection mask wearers can anticipate in a setting where others are not wearing masks and where other public health measures, including social distancing, are in effect. The findings, however, should not be used to conclude that a recommendation for everyone to wear masks in the community would not be effective in reducing SARS-CoV-2 infections, because the trial did not test the role of masks in source control (transmission from an infected person to others) of SARS-CoV-2 infection.

The editors of Annals of Internal Medicine chose to publish the DANMASK-19 trial because it is a well-designed study that provides an important piece of evidence to understand the puzzle of how to control the COVID-19 pandemic. They also note that the U.S. Centers for Disease Control recently updated their guidance to acknowledge that masks, when worn by all, may reduce transmission by both source control and personal protection. They say that the DANMASK-19 trial does not conflict with these guidelines, but shows that any contribution to risk reduction through personal protection is likely to be less than through source control.

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Media contacts: For an embargoed PDF or to speak with an editor of Annals of Internal Medicine, please contact Angela Collom at acollom@acponline.org. The corresponding author, Henning Bundgaard, DMSc, can be reached through Marianne Uldall Jepsen at marianne.uldall.jepsen@regionh.dk.

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Using materials efficiently can substantially cut greenhouse gas emissions

New report details how societies can cut their GHG emissions by ride- and car-sharing, building smaller houses.

NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY

Research News

How much can society gain by cutting consumption of materials --  by using materials smarter, using less or recycling materials? A new report from the International Resource Panel for the United Nations Environmental Programme (UNEP) says the gains are substantial and can be key to enabling countries to meet their emissions targets.

The International Resource Panel (IRP) Report, Resource Efficiency and Climate Change: Material Efficiency Strategies for a Low-Carbon Future is the first comprehensive scientific analysis of potential GHG emission savings from material efficiency. The report, for which Edgar Hertwich, International Chair in Industrial Ecology at the Norwegian University of Science and Technology was a lead author, focused on two carbon-intensive sectors: residential buildings and passenger vehicles.

"Materials are ignored by climate policy, yet emissions from the production of materials production have grown fast!" says Hertwich. "If you are concerned about eating meat or flying on airplanes because of your carbon footprint, you should also be even more worried about cement and steel."

The researchers found that 80% of emissions from the production of materials come from the construction and manufacturing sectors, in particular from our homes and cars.

Applying material efficiency strategies can reduce GHG emissions from the life-cycle of construction, operation, and deconstruction of homes by an average of 40% in seven major developed countries - Canada, France, Germany, Italy, Japan, the United Kingdom and the United States (G7 countries) and by 70% in China and India, the researchers found.

It can also reduce GHG emissions from the manufacturing, operations and end-of-life management of cars by 40% in the G7 and by 35% in China and India.

"This report makes it clear that natural resources are vital for our well-being, our housing, our transportation and our food. Their efficient use is central to a future with universal access to sustainable and affordable energy sources, emissions-neutral infrastructure and buildings, zero-emission transport systems, energy-efficient industries and low-waste societies. The strategies highlighted in this report can play a big part in making this future a reality," said Inger Andersen, Executive Director of the UNEP, in a press release.

The Intergovernmental Panel on Climate Change, the IPCC, has proposed a carbon budget under which the G7 would need to limit their remaining CO2 emissions to 50 gigatons for global average temperature increases to stay at 1.5°C.

The IRP estimates that 23 gigatons of emissions could be saved in the G7 through material efficiency strategies in 2016-2060. The IRP report found that the most promising strategy comes from the consumption side - which would involve more intensive use.

"We were not sure society could live with less materials. Our study show it can: we can easily reduce the amount of primary materials required for a reasonably comfortable living through a combination of less materialistic lifestyles and smarter technologies," says Hertwich.

For cars, this means ride-sharing, car-sharing and a shift towards smaller vehicle sizes. If one in four journeys in the G7, China or India was a shared ride, then the carbon footprint of the use and production of cars would decline by as much as 20%.

For homes, more intensive use means increasing use rates through, for example, peer-lodging, or smaller and more efficiently designed homes. IRP modelling shows that reducing demand for floor space by up to 20% could lower GHG emissions from the production of materials by up to 73% in 2050.

"Limiting the growth in the size of our homes, and sharing rides and vehicles turned out to be the most effective ways to reduce emissions," says Hertwich.

Other material efficiency strategies to be considered include the recycling of building materials, less material by design in both cars and homes, and the use of alternative low-carbon materials (for example, sustainably sourced wood instead of reinforced concrete in homes).

"Climate mitigation efforts have traditionally focused on enhancing energy efficiency and accelerating the transition to renewables. While this is still key, this report shows that material efficiency can also deliver big gains," Andersen, UNEP's Executive Director, said.

The cuts revealed by the report are on top of emission savings generated by the decarbonization of electricity supply, the electrification of home energy use, and the shift towards electric and hybrid vehicles. If the world focuses on energy efficiency without boosting material efficiency, it will be almost impossible and substantially more expensive to meet the Paris climate targets, the report warns.

The report notes that the only way to make many of these kinds of emissions reductions is if countries themselves create enabling policy environments and incentives.

The strongest effect comes from policies that apply across sectors, such as building certification, green public procurement, virgin material taxes, and removal of virgin material subsidies.

The IRP report urges policymakers to consider resource efficiency and materials in the next generation of their Nationally Determined Contributions (NDCs),  broadening the scope of targets and increasing the magnitude of the intended mitigation ambition.

Some countries have started doing this, as described in the Resource Efficiency and Climate report. For example, China's NDC specifically mentions a commitment to the efficient use of materials. It includes measures aimed at improving the efficiency and lifespan of existing and new buildings and promoting recycled construction materials.

Japan's NDC includes a commitment to use blended cement, while India's NDC refers to recycling, "enhanced resources efficiency and pollution control" (in addition to energy efficiency) and the general need to "use natural resources wisely."

"There will be no progress until policy makers turn their attention to this issue," says Hertwich. "Unfortunately, many countries have policies in place that inadvertently increase the use of materials, such as through tax breaks for home ownership. Such policies favour the wealthy and increase material use, so revising them creates a win-win situation."

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Source:  IRP (2020). Resource Efficiency and Climate Change: Material Efficiency Strategies for a Low-Carbon Future. Hertwich, E., Lifset, R., Pauliuk, S., Heeren, N. A report of the International Resource Panel. United Nations Environment Programme, Nairobi, Kenya.

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Mining and megaprojects emerge as alarming threat to tropical forests and biodiversity

Companies, governments and investors are pushing through mining and infrastructure projects, setting the stage for rapid and unsustainable development that will harm forests, wildlife and people--and stoke conflict

MINING COMPANIES ARE LISTED ON THE TSX

IN CANADA

NEW YORK DECLARATION ON FORESTS ASSESSMENT PARTNERS

Research News

Washington, DC//Berlin, Germany (19 November 2020)--A new study assessing progress on global efforts to end forest loss worldwide offers the most comprehensive overview to date of the large role that infrastructure and mining play in tropical deforestation, now and in the future. The study finds that an increasing number of megaprojects--massive and complex development projects that may combine transportation, energy and other infrastructure--planned for tropical forests are on track to destroy forests and open remote forested areas to even more development. In particular, this new infrastructure is on track to increase mining activity deeper in the remote forests of South America, Southeast Asia and Central Africa.

"Forests, forest peoples and wildlife, already at a breaking point, are increasingly in the crosshairs of large infrastructure and mining developments," said Franziska Haupt, Berlin executive director of Climate Focus and the lead author of a new report by the NYDF Assessment Partners, Progress on the New York Declaration on Forests: Balancing forests and development: Addressing infrastructure and extractive industries, promoting sustainable livelihoods.

"Big new projects underway or planned in the Amazon, Indonesia, Mesoamerica, the Congo Basin and beyond reveal that our insatiable appetite for coal, minerals, metals, energy and agricultural commodities like soy has opened up a new front in the battle to protect the world's forests," Haupt added. "Some governments are compounding this threat and rolling back forest protections, as countries struggle to cope with the economic fallout of COVID-19."

Released six years after the launch of the New York Declaration on Forests, a pledge to halve deforestation by 2020 and end it by 2030, the report finds that the 2020 target of halving deforestation will not be met and that meeting the 2030 target of ending deforestation will require an unprecedented reduction in the rate of annual forest loss.

The report is also the first study of its kind to describe the full extent of a pan-tropical trend that sees companies, governments, investors and other actors greenlighting damaging mining and infrastructure projects behind closed doors, while failing to factor in the climate, economic, social and environmental value of forests through effective forest and biodiversity policies. The report also looks at the role that civil society and Indigenous and local communities play in pushing back against these trends.

"Many of these projects would never get the green light, if the true value of forests was factored in--their role in reducing climate change, protecting animal habitats and reducing the spread of zoonotic diseases, keeping water sources clean, providing economic opportunity and a long list of other benefits without a price tag," said co-author and coordinator of the report, Erin D. Matson, a senior consultant at Climate Focus.

In the Pipeline

Economic corridor megaprojects, which link roads, waterways and railways with natural resource extraction, and megadams are planned or under development in most remaining critical tropical forest regions, including South America, Sub-Saharan Africa, Indonesian Borneo and Papua and the Mekong.

  • Across five Amazon countries (Bolivia, Brazil, Colombia, Peru and Ecuador), governments are investing a total of US$27 billion over the next five years to construct or update more than 12,000 kilometers (7,456 miles) of roads. If all planned projects are realized, they will cause the deforestation of approximately 2.4 million hectares over the next 20 years.
  • In Indonesia, the Trans-Papua Highway--a 4,000-kilometer network--will cut through Lorentz National Park, increasing access to over 50,000 hectares of mining concessions inside the park.
  • A railway planned for Kalimantan, Indonesia, would open areas for coal mining and palm oil production. And in neighboring Papua New Guinea, two plans in process would double the length of the country's road network by late 2022.
  • In Sub-Saharan Africa, there is an infrastructure boom organized around dozens of international development corridors to extract, transport and export minerals and energy. These corridors, spanning nations, would cut across 400 protected areas and degrade an additional 1,800.

"The proper analysis of forest impact--a Forest Impact Analysis--for large infrastructure projects remains a major challenge," said reporter contributor Arild Angelsen, a senior associate at the Center for International Forestry Research (CIFOR) and a professor of economics at the Norwegian University of Life Sciences (NMBU). "The overwhelming importance of new infrastructure, and roadmaps in particular, to properly evaluate the fate of forests should make this a top public policy priority."

Mining projects across the tropics are also in operation, with coal mining the most damaging. Studies have shown that deforestation for coal mining delivers a "double whammy" of harmful emissions: Ripping up forests and then producing and burning coal release carbon. Furthermore, the report points out that mining is the world's most violent economic sector, with the largest proportion of reported environmental conflicts in the Environmental Justice Atlas, at 21%, and the most associated murders of environmental defenders--50 in 2019.

A survey conducted as part of the report of mining companies reveals that industry-wide action on biodiversity is lagging, with only a handful of companies reporting they have robust biodiversity policies in place and even less evidence that policies are being put into practice.

"Forests are at a dangerous tipping point, and these new large-scale infrastructure projects and extractive developments could push us over the edge and undermine global efforts to stop deforestation. There's a very small--and closing--window of opportunity now to rethink and reorient these projects in a more sustainable direction. Governments, companies and investors all need to step up, commit to more transparency and act quickly to avoid further harm to people, wildlife and nature," said Matson.

Roads to Deforestation

The report reveals that an unchecked rise in transportation networks is poised to do the most damage to forests. Studies show these roads and networks make it easier for loggers, farmers and others responsible for legally and illegally chopping down trees to access forests. Right now, roadways are responsible for 9% to 17% of tropical and subtropical deforestation, with most new deforestation occurring within one kilometer of a road.

"People need improved access, but these are not highways designed to prioritize linking communities to health care, other essential services or economic opportunities. Rather, their purpose is to facilitate the movement of commodities and to make it easier and cheaper to extract natural capital in ways that benefit economic elites above all. Meanwhile, they unleash a Pandora's box of potential forest damage that does harm to local peoples and biodiversity," said Anthony Bebbington, a leading researcher on extractives and infrastructure and a report co-author. "These road projects are, in turn, part of much more extensive networks of waterways, railways, ports and logistics centers that dramatically increase the likelihood of future deforestation by making once remote forested areas accessible to investment."

In Indonesian Papua and the Congo Basin, road networks have increased by over 40% since the early 2000s. These roads and infrastructure often lead to illegal or unchecked activities that can have significantly higher impacts on forests. In Brazil, for every kilometer of legal road, there are an estimated three kilometers of illegal roads. This also leads to increased contact between humans and wild animals, which is a major contributor to the spread of new zoonotic diseases like COVID-19.

Commitments to Nowhere

The report includes the results of the first-ever survey by CDP, a New York Declaration on Forests Assessment Partner, on the status of the corporate biodiversity commitments of metal, mining and coal companies operating in forested areas. Of some 225 companies invited to report on their efforts, only 23 responded. CDP analyzed an additional 22 companies to provide an analysis of 45 key companies operating in tropical regions.

"There are some signs of progress--more than three-quarters of companies we assessed have made a biodiversity-related commitment," said Morgan Gillespy, Global Director of Forests at CDP, the nonprofit that spearheaded forest-related disclosures of metals and mining companies. Most surveyed companies also indicated that biodiversity or the environment are considered at the highest levels, by their boards or at the senior management level.

"But more work needs to be done," Gillespy said. "Only about a third of companies disclosed details of their biodiversity offset projects, and few shared clear and specific targets for action. Extractive companies, and governments as well, must step up their game by improving transparency and implementing management plans that protect forests."

The report supports findings from other recent studies that high-level corporate commitments among mining companies have not always translated into action at the project level. In fact, several of the stronger commitments were paired with poor practices on the ground. A 2019 World Bank analysis of 29 case study sites of large-scale mining in forests could not find a single example of a mining operation that comprehensively addressed and mitigated forest risks.

"This is a salutary reminder that we are living in a dreamworld of pledges, but a reality of little progress, lack of transparency, vested interests and short-termism," said Robert Nasi, Director General of CIFOR. "Alas, reality will always catch us up."

Barriers to progress include the imbalance of power between, on the one hand, governments and companies that prioritize forest destruction over protection, and, on the other hand, Indigenous and local communities eager to keep forests standing. Government-level barriers include difficulties in implementing existing forest policies due to lack of political will, capacity and stability--and the powerful influence of industry actors. At the corporate level, there is a lack of independent verification of company-reported data on progress, a wide variety and lack of common definitions and norms across mining and limited incorporation of local communities in monitoring efforts.

"Even more fundamental is the absence of meaningful consultation processes to obtain the consent of the affected Indigenous, Afro descendant and local peoples who play such critical roles as forest stewards. Taken together, these barriers constitute profound obstacles to, and failures of, accountability and transparency," Bebbington said.

The report also offers new CDP survey results from 200 state and regional governments about the extent to which mining leads to deforestation in their jurisdictions and their responses to this destruction. Some 21 respondents representing subnational forest states in Latin America and Southeast Asia asserted that mining and infrastructure are a cause of deforestation in their regions and have adopted policies to regulate this activity. But few have translated these policies into concrete forest management plans or systematically assessed their forest risks.

"The solutions to deforestation driven by extractive industries and infrastructure are available, but they are still not being implemented at scale" said Alison Hoare, a senior research fellow at Chatham House and a report co-author.

"This will remain the case unless the full environmental impacts of these sectors are integrated into the decision-making of investors and consumers," Hoare added. "In turn, this would help to open up space for governments to consult with their national stakeholders and to properly consider all options for land-use."

Rollbacks and the Way Forward

In addition, national and local governments have made a series of rollbacks, sometimes using COVID-19 as a justification. Throughout the Amazon, Indigenous communities have suffered sustained violence and threats, including the murder of Indigenous leaders, by groups of small-scale, informal miners. The Brazilian government's decisions to open Indigenous territory to industrial mining and to legalize small-scale mining on Indigenous lands threaten communities further. In Indonesia, a May 2020 law gave mining companies greater freedoms, setting the stage for them to open new mining territory and ramp up exploration activity.

Pulling together all these insights, the report lays out four complementary strategies for reducing the threat that infrastructure and mining pose to forests:

  • Embrace alternative development pathways that reduce over-exploitation, inefficient production and excessive consumption of resources;
  • Align macroeconomic and strategic planning with forest protection goals;
  • Fully assess potential negative forest impacts of new infrastructure and mining projects and devise strategies for minimizing them; and
  • Recognize and account for local communities, and devise ways to promote sustainable livelihoods and address deforestation.

"We're seeing trends playing out across forest nations fueled by decisions at the highest levels. By making way for other drivers of deforestation, infrastructure and mining together pose perhaps the greatest threat to forests and biodiversity," Haupt said. "But with these four strategies, we see a path forward that can realize the full social, economic and environmental benefits of development."


 

Missing in lockdown -- new report reveals the vulnerable are more at risk

UNIVERSITY OF PORTSMOUTH

Research News

The number of people who went missing during the first national lockdown in England fell by over a third, compared to data from the previous year. However, a new report out today shows that those who did go missing were deemed more vulnerable and at higher risk.

Researchers from the University of Portsmouth and University of Liverpool worked with six police forces from across the UK, to understand the impact of lockdown on missing people and recommend changes for the future.

Missing people are one of the most challenging issues for modern police forces, with the number of reported cases reaching 382,960 in 2018/2019 (NCA, 2020). The recent pandemic, and the resultant national as well as localised lockdowns, have placed unique demands on the emergency services (WHO, 2020).

The study aimed to compare the characteristics of missing people cases reported to participating forces during the period of the COVID-19 lockdown in England, with sample of cases taken from the same time period last year. The sample comprised of reports of adults and children who went missing between 23rd March 2020 until 20th May 2020, and the same time period in 2019.

As expected, the lockdown period led to a substantial reduction in the overall number of missing persons. There was a 35% decrease in missing children reports and 36% reduction in reports of missing adults.

However, the research also highlighted that those who went missing were more likely to be high risk of harming themselves or others. Adults who went missing during this period were more prone to mental health issues; domestic abuse; have relationship, drug or alcohol problems; or have a history of self-harm or suicidal thoughts.

Dr Karen Shalev Greene, Reader in Criminology, Director of the Centre for the Study of Missing Persons, University of Portsmouth explains: "The reduction in missing people is entirely expected, it is much harder to go missing, when the country is locked down. However, what is significant about these figures is it highlights how desperate some people must have been."

"The report emphasises the vulnerability of people that go missing during lockdown. Perhaps they live in situations that impact their mental health more making them determined for freedom. Whatever the reason, this is a reflection of society as a whole, including criminal organisations, exploitation, vulnerability and those that need support. To help prevent high risk missing adults from going missing the response needs to be multi agency. Efforts should also focus on after care and support once they return."

The report also highlighted that children were more likely to be classified as low risk during lockdown. The reason for this needs further investigation and understanding.

Dr Freya O'Brien, Senior Lecturer in Psychology, University of Liverpool, explains: "Particular attention should be given to understanding the reasons why children from care homes frequently went missing during lockdown and why children travelled long distances. One theory is that children in care were trying to get home to their families. It is important to bear regional differences in mind. Each force should study the patterns of missing in their force and consider local context."

National Police Chiefs' Council Lead for Missing People, Assistant Chief Constable Catherine Hankinson, said: "This research helps us to understand the changing trends in missing people and the different reasons they went missing during the first lockdown. The trend in more incidents being categorised as high risk suggests some of us really struggled with being isolated from our normal support networks. Police and our partners in health, social care and local authorities need to learn from that experience and consider how we can support people, particularly those with mental health issues, through ongoing restrictions.

"The research found that missing children were more likely to be categorised as low risk which is partly because some of them were reported missing for breaking the lockdown rules but then often returned safe and well after a short time. However, we will closely consider the research in the context of child exploitation, county lines and organised crime. Police are already aware of how these criminals are changing the way they operate but there is always more to do and we're committed to tackling those who are intent on causing harm to our communities and young people.

"Our work with partners in local authorities and social services will consider how we maintain contact with vulnerable children during any further restrictions, as it is vital we all do everything possible to protect them from abuse and exploitation at home."

 

First US nationwide estimates of sexual minority representation in STEM fields

Results suggest a diversity of experiences -- with work to be done to achieve parity

PLOS

Research News

One of the first nationwide estimates of sexual minority representation across Science, Technology, Engineering, and Mathematics (STEM) degrees and occupations in the US publishes November 18, 2020 in the open-access journal PLOS ONE by Dario Sansone from the University of Exeter, UK, and Christopher S. Carpenter from Vanderbilt University, USA.

A body of research has documented wide gaps in STEM degrees and occupations based on gender and race/ethnicity; however, relatively few studies have examined the impact of sexual orientation on STEM representation, due in part to a lack of data. This is the first study to use nationwide datasets two orders of magnitude larger than those used for prior research in this area to illustrate the current state of representation in STEM for sexual minorities.

The authors pulled data from two sources: the 2009-2018 American Community Surveys (ACS), which identifies over 142,000 individuals in same-sex cohabiting romantic relationships and gives information on their current occupation and undergraduate major(s), and the 2013-2018 National Health Interview Surveys (NHIS), which gives detailed information on occupation and sexual orientation for 4,763 self-identified sexual minority individuals. (For the purposes of this study, the authors use the term "sexual minority" to refer to individuals who describe themselves as lesbian, gay, bisexual, queer, or "something else".)

The data indicate that men in same-sex couples are 12 percentage points less likely to have completed a bachelor's degree in a STEM field compared to men in different-sex couples. There was no gap observed for women in same-sex couples versus women in different-sex couples in terms of STEM degree completion. (For context, the STEM degree gap between men in same-sex and different-sex couples is larger than the STEM degree gap between white and black men, but smaller than the gender gap in STEM degrees--meaning women are still overall less likely to obtain a STEM degree regardless of orientation.) In terms of STEM occupations, however, women in same-sex couples are almost two percentage points more likely to work in a STEM field than women in different-sex couples. The gap between men in same-sex couples and different-sex couples is smaller when focusing on STEM occupations, but still present, at a statistically-significant one percentage point (these results were borne out by both the ACS and NHIS surveys). The authors also found that gay male representation in STEM fields (measured using either degrees or occupations) is systematically and positively associated with female representation in those same STEM fields.

There are limitations to the data used--most notably, the ACS survey only focused on cohabiting relationships, meaning that individuals who might be in same-sex relationships (or currently single) but living separately would not have been recognized as part of the sexual minority. (However, the NHIS survey did permit observation of single individuals). Additionally, neither survey used provided specific data on transgender individuals.

However, taken together, the results appears to demonstrate that, like race/ethnicity and gender, sexual orientation is an element that must be considered in order to bring equity and efficiency to STEM fields at the degree and occupation level--and highlights the need for more large nationally representative data on both sexual and gender minorities in STEM to better understand their representation and specific challenges.

The authors add: "We show that sexual minority men are less likely to have completed a bachelor's degree in a STEM field or to work in a STEM occupation compared to heterosexual men. Furthermore, we document that gay male representation in STEM fields (measured using either degrees or occupations) is systematically and positively associated with female representation in those same STEM fields."

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Citation: Sansone D, Carpenter CS (2020) Turing's children: Representation of sexual minorities in STEM. PLoS ONE 15(11): e0241596. https://doi.org/10.1371/journal.pone.0241596

Funding: The authors received no specific funding for this work.

Competing Interests: The authors have declared that no competing interests exist.

In your coverage please use this URL to provide access to the freely available article in PLOS ONEhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0241596

 Machine learning uncovers missing info about ethnicity in population health data: Study

University of Alberta epidemiologist says these key social determinants of health are often not tracked adequately in Canada

UNIVERSITY OF ALBERTA FACULTY OF MEDICINE & DENTISTRY

Research News

IMAGE

IMAGE: KAI ON WONG FOUND THAT MACHINE LEARNING CAN BE USED TO PREDICT ETHNIC BACKGROUND FROM PUBLIC HEALTH DATA, WHICH WOULD HELP FILL AN INFORMATION GAP AND COULD EVENTUALLY INFORM POLICIES... view more 

CREDIT: UNIVERSITY OF ALBERTA

Machine learning can be used to fill a significant gap in Canadian public health data related to ethnicity and Aboriginal status, according to research published today in PLOS ONE by a University of Alberta research epidemiologist.

Kai On Wong, senior data scientist at the Real World Evidence unit of the Northern Alberta Clinical Trials and Research Centre (NACTRC), said ethnicity and Aboriginal status are recognized as key social determinants of health but are often not reported in large databases that track acute and chronic diseases such as asthma, influenza, cancer, cardiovascular diseases, diabetes, disability and mental illness.

"If a database currently lacks ethnicity information, we will not be able to tell whether certain ethnic groups have higher rates of disease or worse clinical outcomes," Wong said, "This is a way to unlock that missing dimension from existing data sources, which may help us understand, monitor and address issues such as social inequities and racism in Canada."

Wong created a machine learning framework to analyze the names and geographic locations of 4.8 million people surveyed in the 1901 census, examining features such as spelling and phonetics to predict whether they belonged to one of 13 ethnic groups.

"Different ethnic and linguistic groups have different manifestations of features such as how the name sounds, how many letters in the name, how many vowels and unique letter sequences, and so on," said Wong, who created the program and shared it as a public GitHub repository as part of his doctoral thesis at the U of A's School of Public Health.

"Machine learning is like having a team of agents who are given vast amounts of information. They are instructed to detect and retain useful patterns to solve practical problems such as predicting the ethnicity from the readily available information," he said.

Wong said the program performed best at identifying individuals of Chinese, French, Japanese and Russian heritage based on name only, while the accuracy was improved for the Aboriginal classification when locations were also included.

Both the World Health Organization and the Government of Canada recognize ethnicity and Indigeneity as determinants of health, along with other factors such as income, education and gender. Wong first became interested in inequities in health care that affect Indigenous groups when he served as acting territorial epidemiologist for the Government of the Northwest Territories.

Wong said while American health records tend to include questions about ethnicity, this information is not collected consistently in Canadian databases ranging from hospital discharge records to cancer registries.

By using machine learning to uncover this missing information, researchers and policy-makers will be able to learn more from existing records rather than having to carry out new population-level surveys, which are expensive and time-consuming.

"A future step forward will be to validate this research with real-world applications using health evidence augmented with ethnicity generated by the machine learning framework and comparing it with existing literature, particularly on health and social inequities," Wong said.

Wong recommends first updating the ethnicity prediction tool using more recent census information and testing its accuracy when applied to various health records.

"It is unrealistic to expect machine learning predictions to be 100 per cent accurate at all times," Wong said. "The goal is to make predictions that are accurate and generalizable enough to discern underlying patterns in a meaningful way for a particular problem or application."

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Wong's research was funded by the Canadian Institutes of Health Research Frederick Banting and Charles Best Doctoral Research Award, the University of Alberta President's Doctoral Prize of Distinction and Queen Elizabeth II Doctoral Scholarship, and the Alberta Machine Intelligence Institute (Amii).

 

New studies find financially exploited seniors show brain differences and are more frail

New light shed on older peoples' risk for scams and fraud in a pair of studies from the Keck School of Medicine of USC

KECK SCHOOL OF MEDICINE OF USC

Research News

IMAGE

IMAGE: S. DUKE HAN, PHD, KECK SCHOOL OF MEDICINE OF USC view more 

CREDIT: RICHARD CARRASCO

Scams and fraud exact a heavy toll on older adults, with estimates of yearly losses ranging from $3 billion to $36 billion in the U.S. alone.

Lasting damage can occur. Because many seniors live off of resources accumulated across their working lifetimes, such as retirement savings, victims may be unable to recoup what's taken from them. Considering the additional impact on family members and caretakers, financial exploitation in this growing demographic is a significant public health concern.

Two recent studies led by USC provide new insight into the little-studied question of which factors put older adults at risk for financial exploitation.

One, published in Frontiers in Aging Neuroscience, is only the second brain imaging study to center on financial exploitation in older adults. The scientists found that those who report being financially exploited show differences in the activity of brain regions tied to decision-making and social judgments compared to those without a history of financial exploitation.

The other, which appears in Gerontology and Geriatric Medicine, is the first study to focus specifically on the relationship between financial exploitation and frailty in older adults. The findings showed that those who reported being financially exploited are frailer physically -- with particular deficits in vision and hearing -- compared to their peers.

The papers come out of the Finance, Cognition, and Health in Elder Study at USC, which enrolls participants who are 50 years and older with no history of dementia. It is led by Duke Han, senior author on both publications and professor of family medicine, neurology, psychology and gerontology in the Keck School of Medicine of USC.

"Ultimately, we want older adults to experience all the best in life, to hold onto their wealth and to live life well into old age," said Han, who is also director of neuropsychology in the USC Department of Family Medicine. "It crushes us to see them financially exploited. However, not all older adults are at risk for financial exploitation, and we want to try to predict which people might be more at risk."

Brain differences correlate with falling victim to fraud

The Frontiers in Aging Neuroscience study used magnetic resonance imaging to examine neurological co-activity. Han and his colleagues compared 16 older adults who reported experiencing financial exploitation with 16 who did not, studying their brains while in a resting state. The scientists delved into functional connectivity -- in other words, which brain regions activate at the same time.

Functional connectivity can serve as a sort of canary in the coal mine, signaling changes that come with age-related diseases, including Alzheimer's, before alterations to structures in the brain are detectable.

The research team focused in on three areas of the brain tied to making decisions and evaluating social situations. The study demonstrated subtle but significant differences between connectivity in these regions among those who reported financial exploitation compared to the control group:

  • The medial frontal cortex, which is a seat of executive functioning in the brain

  • The hippocampus, which is tied to remembering specific events and envisioning future scenarios

  • The insula, which is associated with evaluating the trustworthiness of people or situations

"It makes sense that the ability to project a future self through the hippocampus and the ability to assess trustworthiness through the insula might be implicated in financial exploitation risk," Han said.

However, he emphasizes that the current study indicates correlation rather than causation. To zero in on cause and effect, a larger study that follows participants over time is necessary. Han is currently seeking federal grant funding to pursue such a study.

Problems seeing and hearing may put seniors at risk

For the Gerontology and Geriatric Medicine research, Han and his team employed a widely used questionnaire for identifying frailty to compare 24 seniors who reported financial exploitation with 13 peers who hadn't experienced it. The assessment asked about physical issues including fatigue, difficulty walking and poor hearing or vision; psychological issues such as anxiety and problems remembering; and social issues such as isolation and loneliness.

The participants who had experienced financial exploitation reported being significantly frailer than the control group, with that difference showing up on the physical scale but not the measures of psychological or social frailty. Specifically, they reported significantly poorer hearing and marginally poorer sight.

Although this study dealt in correlations, Han notes that it's unlikely that financial exploitation leads to hearing or vision loss.

"The methods that scammers and fraudsters use put a stress on being able to see and hear things accurately," he said. "It stands to reason that this would actually be a mechanism for how certain older adults might be more vulnerable to financial exploitation."

The researchers hope to build on these findings to conduct a larger study that investigates whether measures such as the use of hearing aids and properly calibrated corrective lenses provide protection against financial exploitation.

"This research really does point to the importance of regular visits with a doctor and keeping up on your hearing and vision," Han said. "If we can confirm the clinical relevance and then get the word out that the more you address sensory functioning, the more it potentially protects you against financial exploitation, then all the better."

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About the studies

The first author of the Frontiers in Aging Neuroscience study is Gali Weissberger, a former postdoctoral scholar from Han's lab at the Keck School of Medicine. Other authors are Dr. Laura Mosqueda, Annie Nguyen, Jenna Axelrod and Caroline Nguyen, all of the Keck School; Patricia Boyle of Rush University Medical Center; and Nathan Spreng of McGill University in Canada.

Axelrod, a postdoctoral scholar from Han's research group, is the first author of the Gerontology and Geriatric Medicine paper. The Keck School's Dr. Mosqueda, Weissberger, Nguyen and Emanuil Parunakian were co-authors, along with Boyle from Rush University.

Both studies were supported by the Elder Justice Foundation, the Cathay Bank Foundation, the National Institute on Aging (T32-AG000037) and the USC Department of Family Medicine.

New technique seamlessly converts ammonia to green hydrogen

Researchers leverage renewable electricity for widespread, distributed hydrogen fuel production

NORTHWESTERN UNIVERSITY

Research News

Northwestern University researchers have developed a highly effective, environmentally friendly method for converting ammonia into hydrogen. Outlined in a recent publication in the journal Joule, the new technique is a major step forward for enabling a zero-pollution, hydrogen-fueled economy.

The idea of using ammonia as a carrier for hydrogen delivery has gained traction in recent years because ammonia is much easier to liquify than hydrogen and is therefore much easier to store and transport. Northwestern's technological breakthrough overcomes several existing barriers to the production of clean hydrogen from ammonia.

"The bane for hydrogen fuel cells has been the lack of delivery infrastructure," said Sossina Haile, lead author of the study. "It's difficult and expensive to transport hydrogen, but an extensive ammonia delivery system already exists. There are pipelines for it. We deliver lots of ammonia all over the world for fertilizer. If you give us ammonia, the electrochemical systems we developed can convert that ammonia to fuel-cell-ready, clean hydrogen on-site at any scale."

Haile is Walter P. Murphy Professor of materials science and engineering at Northwestern's McCormick School of Engineering with additional appointments in applied physics and chemistry. She also is co-director at the University-wide Institute for Sustainability and Energy at Northwestern.

In the study, Haile and her research team report they are able to conduct the ammonia-to-hydrogen conversion using renewable electricity instead of fossil-fueled thermal energy because the process functions at much lower temperatures than traditional methods (250 degrees Celsius as opposed to 500 to 600 degrees Celsius). Second, the new technique generates pure hydrogen that does not need to be separated from any unreacted ammonia or other products. Third, the process is efficient because all of the electrical current supplied to the device directly produces hydrogen, without any loss to parasitic reactions. As an added advantage, because the hydrogen produced is pure, it can be directly pressurized for high-density storage by simply ramping up the electrical power.

To accomplish the conversion, the researchers built a unique electrochemical cell with a proton-conducting membrane and integrated it with an ammonia-splitting catalyst.

"The ammonia first encounters the catalyst that splits it into nitrogen and hydrogen," Haile said. "That hydrogen gets immediately converted into protons, which are then electrically driven across the proton-conducting membrane in our electrochemical cell. By continually pulling off the hydrogen, we drive the reaction to go further than it would otherwise. This is known as Le Chatelier's principle. By removing one of the products of the ammonia-splitting reaction--namely the hydrogen--we push the reaction forward, beyond what the ammonia-splitting catalyst can do alone."

The hydrogen generated from the ammonia splitting then can be used in a fuel cell. Like batteries, fuel cells produce electric power by converting energy produced by chemical reactions. Unlike batteries, fuel cells can produce electricity as long as fuel is supplied, never losing their charge. Hydrogen is a clean fuel that, when consumed in a fuel cell, produces water as its only byproduct. This stands in contrast with fossil fuels, which produce climate-changing greenhouse gases such as carbon dioxide, methane and nitrous oxide.

Haile predicts that the new technology could be especially transformative in the transportation sector. In 2018, the movement of people and goods by cars, trucks, trains, ships, airplanes and other vehicles accounted for 28% of greenhouse gas emissions in the U.S.--more than any other economic sector according to the Environmental Protection Agency.

"Battery-powered vehicles are great, but there's certainly a question of range and material supply," Haile said. "Converting ammonia to hydrogen on-site and in a distributed way would allow you to drive into a fueling station and get pressurized hydrogen for your car. There's also a growing interest for hydrogen fuel cells for the aviation industry because batteries are so heavy."

Haile and her team have made major advances in the area of fuel cells over the years. As a next step in their work, they are exploring new methods to produce ammonia in an environmentally friendly way.

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The paper is titled "Solid Acid Electrochemical Cell for the Production of Hydrogen from Ammonia." It was published online in Joule on Nov. 3 and was released in print on Nov. 18. Other authors include researchers from SAFCell, an energy startup company based in California.

Pod e-cigar study finds e-cigarettes less harmful than regular cigarettes, new

 BROWN UNIVERSITY

Research News

PROVIDENCE, R.I. [Brown University] -- Cigarette smoking causes more than 480,000 deaths each year in the United States, according to federal government data -- and some smokers find it nearly impossible to quit. Many of these smokers use regular, or combustible, cigarettes.

Physicians and scientists have for many years explored the health benefits and drawbacks of nicotine-based alternatives to cigarettes, and new research offers significant evidence that "pod" e-cigarettes are less damaging to health than traditional cigarettes.

"Nicotine is one of the most addictive substances on earth, both in animal models as well as to humans," said Dr. Jasjit S. Ahluwalia, a professor of behavioral and social sciences and medicine at Brown University. "So how can we help these people who can't quit smoking combustible cigarettes? They need other options, and e-cigarettes may be one such option. Our research shows that in the short-term, e-cigarettes are considerably safer than combustible cigarettes."

Ahluwalia is senior author of a new JAMA Network Open study, published on Wednesday, Nov. 18, on the world's first randomized clinical trial of fourth-generation pod e-cigarettes.

The trial included 186 African American and Latinx smokers, as racial and ethnic minority groups tend to experience higher rates of tobacco-related morbidity and mortality even when they smoke at the same rates as other groups. Two-thirds of the participants were provided e-cigarettes for six weeks, while the remaining participants were instructed to continue smoking combustible cigarettes as usual.

By the end of the study, participants who switched to e-cigarettes exhibited significantly lower levels of the potent pulmonary carcinogen NNAL compared to those who continued to smoke combustible cigarettes exclusively. The e-cigarette users also had significantly reduced carbon monoxide (CO) levels and reported fewer respiratory symptoms. These benefits -- reduced NNAL, reduced CO and respiratory symptom improvements -- were especially pronounced among participants who switched completely to e-cigarettes.

The researchers also measured participants' levels of cotinine, a breakdown product of nicotine, and determined that there were no significant differences between groups, an indication that e-cigarettes provided adequate replacement of nicotine.

"Anyone under 21 should not take up cigarettes, e-cigarettes or any nicotine product -- hands down, the best thing to do is to never start -- but if people use tobacco products, they should quit," Ahluwalia cautioned. "But if they cannot quit smoking combustible cigarettes, they should consider using novel nicotine products to either quit smoking altogether or to reduce their harm by transitioning fully to these products."

Going forward, work needs to be done to better understand the non-cancer risks associated with e-cigarettes, such as respiratory and cardiovascular disease. The researchers also plan to carry out year-long studies to further explore the harm-reduction potential of e-cigarettes.

"Most smokers who switched exclusively from combustible cigarettes to e-cigarettes during the study maintained this behavior at six months, but we need longer-term follow-up," said Kim Pulvers, a professor of psychology at California State University San Marcos who was the principal investigator of the study. "We also need continued study of dual users to determine whether they maintain harm reduction over time."

Ahluwalia said that because many individuals who use both e-cigarettes and combustible cigarettes will switch back to exclusively combustible cigarettes over time, there is a critical need for interventions that support those who try to switch to e-cigarettes but fail. He also emphasized the importance of alternatives to quitting outright, given the challenge that quitting poses for so many cigarette smokers.

"It's possible that nicotine e-cigarettes and other harm-reduction products will be game-changers for our field," Ahluwalia added. "I hope this study stimulates more people to do this research and to have an open mind about this. I also hope it inspires them to let science inform policy rather than emotion."

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In addition to Ahluwalia and Pulvers, additional contributors include Christopher H. Schmid and Kexin Qu from Brown; Nicole L. Nollen from the University of Kansas School of Medicine; Dr. Neal Benowitz from the University of California, San Francisco; and Myra Rice from California State University San Marcos.

Schmid served as a consultant for legal firms representing Eli Lilly, Boehringer-Ingelheim and Gilead outside the study. Benowitz received personal fees from Pfizer and Achieve Life Sciences and served as a consultant to pharmaceutical companies that market smoking cessation medications and as an expert witness in litigation against tobacco companies outside the study. Dr. Ahluwalia received personal fees from Lucy Goods outside the study. These points were fully disclosed in the study.

The study was funded by the National Institutes of Health (5SC3GM122628) and was also supported by the NIH-funded Center of Biomedical Research Excellence (P20GM130414) and the National Institute of General Medical Sciences of the NIH (U54GM115677).