Saturday, January 23, 2021

How political symbolism brought down Keystone XL

Aaron Wherry, CBC

  
© Nicholas Kamm/AFP/Getty Images Students protesting against the proposed Keystone XL pipeline chant slogans in front of the White House in Washington, DC on March 2, 2014.

The new president of the United States described his inauguration on Wednesday as a moment to move forward. But moving forward properly requires a reckoning with the past. In Joe Biden's case, that reckoning came for the Keystone XL pipeline.

The project's fate seemed to be sealed years ago, but it haunts us still.
And now, with strident words from Alberta Premier Jason Kenney about a trade war, it could haunt Canadian politics indefinitely.

Or, Canadian leaders could decide that it's time for them to move forward, too.


The executive order that rescinded Keystone XL's permit on Wednesday states that "the United States must be in a position to exercise vigorous climate leadership in order to achieve a significant increase in global climate action and put the world on a sustainable climate pathway."

If that sounds familiar, it's because President Barack Obama said almost the same thing when he blocked Keystone in November 2015. "America is now a global leader when it comes to taking serious action to fight climate change," Obama said. "And frankly, approving this project would have undercut that global leadership."


John Kerry — secretary of state in 2015 and now Biden's climate envoy — put an even finer point on the significance of Keystone in his own statement at the time. "The United States cannot ask other nations to make tough choices to address climate change if we are unwilling to make them ourselves," he said.

A pipeline that became a referendum


In his remarks, Obama argued that the practical value of the pipeline had been wildly overstated — by both sides. Keystone XL, he said, would be neither "a silver bullet for the economy, as was promised by some, nor the express lane to climate disaster proclaimed by others."

But the economic arguments in favour of the pipeline could not overcome the profound symbolic value assigned to it by environmental groups and climate-focused voters.

On its own, Keystone wouldn't spell the difference between a green future and a "climate disaster." But the pipeline became a referendum on the U.S. government's commitment to combating climate change — a tangible thing on which American activists could focus their energies.

Trump, who actively sought to undermine attempts to fight climate change, revived the project. But the political frame that was placed around Keystone XL in 2015 never went away, while legal challenges to the project continued.

By the fall of 2019, most of the major Democratic candidates for the presidency had pledged to rescind Trump's order on their first day in office. Last May, Biden insisted that he would kill the pipeline.© Patrick Doyle/The Canadian Press Prime Minister Justin Trudeau and then-U.S. Vice President Joe Biden walk down the Hall of Honour on Parliament Hill in Ottawa on Friday, December 9, 2016.

After Biden's victory in the presidential election, the Eurasia Group said that rescinding the permit was a "table stake" for the Democratic president and that backing away would risk "raising the ire of activists, their committed followers, and — importantly — the left wing of the Democratic party in Congress."

"Rescinding KXL would be one area the Biden administration could act [on] and deliver a win to a key political constituency with no congressional interference," the global consulting firm said.

Bill McKibben, one of the activists who led the campaign against Keystone, wrote in the New Yorker on Thursday that he was grateful for Biden's decision and never doubted that the new president would follow through. "Even today," he wrote, "Keystone is far too closely identified with climate carelessness for a Democratic president to be able to waver."

So the second death of Keystone shouldn't have surprised anyone. It might have seemed rude of Biden to not wait a day or two to allow Canadian officials to make a fuller presentation on the pipeline's behalf, but that only would have delayed the inevitable.
The lingering costs of climate inaction

Perhaps Biden thought he was doing his neighbours a favour by ripping the Band-Aid off quickly.

What might have happened to Keystone XL had Canada and the United States taken more aggressive measures to reduce greenhouse gas emissions in the years leading up to Obama's decision? It's an intriguing hypothetical. Keystone may have paid the price ultimately for decades of global inaction on climate change.

In the here and now, any debate about Keystone will have to consider whether its additional capacity is even needed at this point. In the meantime, Premier Kenney wants Justin Trudeau's government to impose trade sanctions on the United States if Biden refuses to revisit his decision.

Stephen Harper could be ungracious in his defence of Keystone — he famously said that approving it was a "no brainer" — but his government doesn't seem to have ever publicly threatened to impose sanctions if Obama rejected it. Nor does it appear anyone called for sanctions when Obama officially killed the project shortly after the Trudeau government came to office.
Sanctions out of spite?

This idea of reprisals seems to have originated recently with Jack Mintz, a Canadian economist, who also conceded that imposing tariffs could be akin to "cutting off our own nose to spite our face."

Notably, Erin O'Toole's federal Conservatives have not joined the premier in calling for sanctions. Kenney — whose government is polling poorly and whose party is being out-fundraised by the opposition — is spoiling for a fight. He has seized on the fact that federal officials did not respond to Biden's decision in particularly strong terms — and the Liberals may not have struck the right tone for those listening in the Prairies.

But before launching a trade war against this country's closest ally and its new leader, one should consider the potential results and opportunity costs.

Would a trade war convince President Biden to brave the wrath of his supporters and reverse a campaign promise? Or would a renewed fight over Keystone XL simply consume political and diplomatic capital that could be put toward other things?

Kenney has said sanctions might discourage the Biden administration from intervening against two other contested pipelines that originate in Alberta — Line 5 and Line 3. Writing in the New Yorker, McKibben did identify Line 3 as a target. But there's also a decent chance that sanctions would only inflame existing tensions around those projects.
Threats and futility

In May, 2015 — nearly six years ago — former Canadian diplomat Colin Robertson wrote that it was time for the Canada-U.S. relationship to move on from Keystone XL. Robertson argued that there were too many other important things to talk about. Six years later, that list of important things includes fostering collaboration on clean energy, fending off 'Buy American' policies and combating China's aggression.

Still, Kenney warned that if the Trudeau government does not do more to defend Keystone, "that will only force us to go further in our fight for a fair deal in the federation."

But if the battle for Keystone was effectively lost more than five years ago, should the federal government's willingness to keep fighting it have any bearing on Alberta's relationship with the rest of the country?

The death of Keystone XL will have a real impact on those Albertans whose jobs depended on it. There are real anxieties and questions that need to be addressed, not least by the federal government.

But the question now is whether fighting over Keystone will do anything to address those concerns — or whether it's time to put that political energy toward other purposes.
Capitol attack reflects US extremist evolution over decades


The takeover in 2016 by right-wing extremists of a federal bird sanctuary in Oregon. A standoff in 1992 between white separatists and federal agents in Ruby Ridge, Idaho. The 1995 bombing of a federal building in Oklahoma City that killed 168 people.

© Provided by The Canadian Press

Right-wing extremism has previously played out for the most part in isolated pockets of America and in its smaller cities. The deadly assault by rioters on the U.S. Capitol, in contrast, targeted the very heart of government.

And it brought together, in large numbers, members of disparate groups, creating an opportunity for extremists to establish links with each other.

That, an expert says, potentially sets the stage for more violent actions.

“The events themselves, and participation in them, has a radicalizing effect. And they also have an inspirational effect. The battle of Capitol Hill is now part of the mythology,” said Brian Michael Jenkins, a terrorism expert and senior adviser to the president of the RAND Corporation think-tank .

Mary McCord, a former acting U.S. assistant attorney general for national security, said the climate for the insurrection had been building throughout the Trump presidency.

She cited the 2017 “Unite the Right” white supremacist rally in Charlottesville, Virginia that killed one person, aggressive demonstrations at statehouses by armed protesters railing against COVID-19 public health safety orders and mass shootings by people motivated by hate.

“All have led to this moment,” McCord, now a visiting law professor at Georgetown University Law Center, said in an email.

The Southern Poverty Law Center, which monitors U.S. extremists, has recorded a 55% increase in the number of white nationalist hate groups since 2017.

Among those who participated in the Jan. 6 assault on the U.S. Capitol were members of the Oath Keepers, which often recruits current and former military, police or other first responders; the Proud Boys neo-fascist group; followers of QAnon, which spreads bizarre conspiracy theories; racists and anti-Semites; and others with nearly blind devotion to then-President Donald Trump.

“January 6th was kind of a Woodstock of the angry right,” Jenkins said in an interview. “The mere fact those groups were coming together, mingling, sharing this anger, displaying this passion — it is going to have effects.”

But what happens next? Will Jan. 6 be a high-water mark for right-wing extremists, or lead to other attacks on America's democracy?

Right now, the movement — if it can be called that — seems to be on pause.

Supposedly planned armed protests at all 50 state capitals and Washington this past week that the FBI issued a nationwide warning about drew virtually no one. That could indicate the groups are demoralized, at least temporarily.

Donald Trump is no longer president and his social media reach has been severely curtailed, with Twitter banning him. The extremists had come together in Washington on Jan. 6 because of their fervent belief in Trump's lies that the presidential election had been stolen, and in response to Trump's tweeted declaration that the protest in Washington “will be wild.”

But now, some are clearly angry that Trump disassociated himself with the very insurrection that he stoked. They're upset that he failed to come to the rescue of rioters who were arrested while he was still president and are still being detained and charged.

Online, some people associated with the Proud Boys, which adored Trump, appear to have dumped him.

“No pardons for middle class whites who risked their livelihoods by going to ‘war' for Trump," a Telegram channel associated with the group said after Trump issued many pardons, but none for the insurrectionists.

Another posting on the channel said: “I cannot wait to watch the GOP completely collapse. Out of the ashes, a true nationalist movement will arise.”

Believers in QAnon are also reeling after Trump left office without fulfilling their baseless belief that he would vanquish a supposed cabal of Satan-worshipping cannibals, including top Democrats, operating a child sex trafficking ring.

Among them was Ron Watkins, who helps run an online messaging board about QAnon conspiracy theories.

“We gave it our all. Now we need to keep our chins up and go back to our lives as best we are able,” Watkins wrote on Telegram after President Joe Biden was sworn in and Trump flew off to Florida.

Jenkins said the next phase for the extremist groups and people who saw Trump as a saviour could transform into a broader national movement in which factions co-ordinate and combine their assets.

Or the widespread condemnation of the insurrection could cause the movement to shrink, leaving more determined elements to strike out on their own and launch attacks.

Jenkins recalled the 1970s, when some anti-Vietnam War militants hardened into the Weather Underground, which launched a bombing campaign. Among places targeted were the U.S. Capitol and the Pentagon, but the only people who died were three militants who accidentally blew themselves up.

“I think given the events of this past year, and especially what we’ve seen in the last couple of months, this puts us into new territory," Jenkins said "And you don't put this back in the box that easily."

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Associated Press writers Amanda Seitz in Chicago and Garance Burke in San Francisco contributed to this report.

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Follow Andrew Selsky on Twitter at https://twitter.com/andrewselsky

Andrew Selsky, The Associated Press
Thank You To Chuck Schumer, For Mixing Up “Erection” With “Insurrection” On The Senate Floor

'NO REVOLUTION WITHOUT GENERAL COPULATION' MARAT SADE

As lawmakers are preparing to hold former President Donald Trump accountable on impeachment charges of inciting an insurrection, Senate Majority Leader Chuck Schumer and House Speaker Nancy Pelosi spoke out on Friday after Pelosi said she would deliver the articles of impeachment to the Senate.
© Provided by Refinery29 Senate Minority Leader Chuck Schumer, a Democrat from New York, speaks during a news conference at the U.S. Capitol in Washington, D.C., U.S. on Thursday, Oct. 1, 2020. U.S. House Speaker Nancy Pelosi said there are still major differences to be bridged in the negotiations over a fiscal stimulus package with Treasury Secretary Steven Mnuchin. Photographer: Stefani Reynolds/Bloomberg via Getty Images

Schumer announced the news on the Senate floor Friday morning, telling lawmakers that he was in discussions with Senate Minority Leader Mitch McConnell on how long the trial will last and when it will begin. “But make no mistake, a trial will be held in the United States Senate, and there will be a vote whether to convict the president,” Schumer told the Senate.

Then, something special happened: It was Schumer’s next line in his address to US senators that caused a much-needed laugh for some, if not a moment of (humble) embarrassment for the Senate Majority Leader. “When that trial ends, senators will have to decide whether they believe Donald John Trump incited the erection — insurrection — against the United States.” It was an unfortunate, yet hilarious, gaffe in the very serious matter of convicting a former president on charges of inciting the violent siege of the US Capitol. But it was the gaffe we all needed after a very serious week.

I regret to inform you that Chuck Schumer just said ‘erection’ instead of ‘insurrection’ on the Senate floor pic.twitter.com/U5xRRnkaQg— Dave Jamieson (@jamieson) January 22, 2021

In seriousness, Schumer is currently in talks with McConnell to solidify a start date for the trial after receiving a proposal from the Senate Minority Leader requesting to start the trial on February 13. But Schumer reportedly rejected McConnell’s last-minute request and is attempting to push forward with the trial. Whether or not both parties ultimately agree on whether to push the start date back, sources told CNN the articles will be read and senators and the presiding officer will be sworn in Tuesday afternoon.

The House voted to impeach the former president on January 13, just one week before President Joe Biden was inaugurated on the 20th. While Trump is no longer a sitting president, the Senate now has an opportunity to make sure he will never again be legally allowed to become president, after encouraging his supporters to overthrow the 2020 election results by force.

While Schumer was noticeably embarrassed by his “erection” comment, it was also a moment of levity that many people needed on this first Friday in Joe Biden’s America. And for that, we thank him.

Antifa.com redirects to White House website as trolls needle Biden

If you point your browser to antifa.com, you won't find black-outfitted protesters challenging racists and far-right extremists in a tense face-off. Instead, the URL will take you to President Joe Biden's spiffy new White House website, which has recently been redone to include accessibility features and a hidden message to coders
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© Provided by CNET White House

Don't let the apparent connection between the antifascist movement and the newly sworn-in president alarm or outrage you. The redirect is simply a reflection of how the open web can work. Anyone with a few bucks can register an internet address, set up a website on it, and then take visitors to another website.

Often redirects are nothing more than harmless jokes, like a redirecting to videos of Rick Astley's Never Gonna Give You Up, an internet prank that's come to be known as rickrolling. Sometimes, however, redirects are unsavory gags or deliberate misdirection.

The website redirect, a phenomenon that's dogged Biden since before he won the November election, is a good reminder to avoid jumping to conclusions based on something you see on the internet. Be even more careful about sharing your find with family and friends until you've vetted the source. Simply put, there's no shortage of disinformation, misinformation, propaganda, baseless conspiracy theories and flat-out lies online.


It's advice Republican Sen. Ted Cruz perhaps should've taken to heart before he tweeted in September that clicking on antifa.com told you "all you need to know." At that time, antifa.com redirected people to the Biden campaign website in an apparent attempt to falsely link the candidate to the loosely organized left-wing network. Conservative figures, including former President Donald Trump, have often called antifa activism an assault on law and order.© White House

It isn't clear who runs antifa.com. The public record of its ownership offers an identity obscured by a privacy service. Website hosting companies aren't required to disclose details.

Anyone could've set up the site. The same goes for the loser.com website, which redirects to the Trump Wikipedia page and which is run by an operator with a shielded identity.

The operator of antifa.com didn't respond to a request for comment. Neither did the White House or Cruz's office. In a September tweet, Rob Flaherty, the Biden campaign's digital director, called the antifa.com redirect the work of a troll, adding that Biden "obviously has/wants nothing to do with fringe groups."
Website shenanigans

No single authority fully controls the web or the internet. That's been a boon for free expression, but it's also opened up avenues for trouble.

In the early days of the internet, "cybersquatting" was a common problem. Companies or other organizations that wanted to set up a website often discovered that someone else had already registered the name and would transfer rights only for a hefty fee. The US and other countries have passed laws to curb the practice.

A related phenomenon, typo squatting, is designed to take advantage of people who misspell domain names, like using .cm instead of .com. That can fool people into entering sensitive information into a fake phishing site.

ICANN, the Internet Corporation for Assigned Names and Numbers, oversees the internet domain technology and has some mechanisms for trademark protection, but its role is limited. It doesn't referee issues such as redirects. "Our bylaws prohibit us from getting involved in website content-related matters," the organization said in a statement.

There are always new worries. One company, Vox Populi Registry, sells .sucks domains and says, "If you don't own your sh*t, someone else will."

Other tricks take the idea a level deeper. A practice called Google bombing manipulated websites to fool Google's algorithm so, for example, a search for "miserable failure" showed former President George W. Bush as the top result. (Google adjusts its software to try to shut off such manipulation mechanisms.)

Companies like Reputation.com exist to try to help people spruce up their online presence.
Antifa.com past and present

Antifa.com has had different incarnations over the years. The Internet Archive's Wayback Machine shows it was around back in 1999, though not with an active website initially. In 2000 and 2001, it was apparently used to publish antifa-related website information. By 2008, the domain was up for sale.

In 2020, the URL seems to have gotten active again, first with a website that appears to have promoted antifa causes, then with a redirect to Biden's campaign website. It's also pointed to buildbackbetter.org, a Biden transition website, and to Vice President Kamala Harris' kamalaharris.org site. It's also pointed to itsgoingdown.org, a website "for anarchist, anti-fascist, autonomous anti-capitalist and anti-colonial movements."

Don't expect clarity on antifa.com anytime soon, however. After all, this is the internet.
MERE ANARCHY

Portland protests: Here's why they're gathering

Rioters again took to the streets of Portland, Oregon, on Thursday -- the first full day of Joe Biden's presidency -- to let the Democratic establishment know they are still fighting for racial justice, some told CNN.  

THESE ARE THE RIOTERS
© John Rudoff/Sipa USA
PORTLAND AND SEATTLE COPS CAUSE THE RIOTS

"We wanted to symbolize that both parties are the oppressor," said a 25-year-old who wished not to be identified, fearing government reprisal. "We've all experienced firsthand that police violence is police violence regardless (of which political party holds power). ... It doesn't make a difference to the person being beaten."

"For White people, maybe they feel there's time to let the administration work, but for Black and Indigenous people who have had a rope around their neck, there is no time," the 25-year-old said. "There's no justice, so there is no peace."

Biden in his inaugural speech Wednesday called for racial justice and unity in America, acknowledging the nation has been deeply divided by systemic racism and political forces. He denounced White supremacy and domestic terrorism and said the country must be healed.

"A cry for racial justice, some 400 years in the making, moves us," Biden said. "The dream of justice for all will be deferred no longer."

Still, rioters wearing all black clothing and gas masks took to the streets Thursday in Portland, where social justice demonstrations have endured for months. Rioters there a day earlier had vandalized the state Democratic Party headquarters and a federal US Immigration and Customs Enforcement, or ICE, building, police said, and four people have been charged in connection with those events.

CNN witnessed more arrests on Thursday night, when most people attending a riot at the ICE building were White. Indeed, the demographic of Portland's protest movement has often been criticized. Protesters say it should be neither surprising, given that the city is 77% White.

"I want to dispel that White anarchists are co-opting this for their own gain," said the 25-year-old rioter, who is White and told CNN he's lived in Portland for most of his life. "There are Black and Indigenous people out there that can't have the same outward action as White people can."

'It doesn't matter who's president'

Some rioters' anger is fueled by their assumption the Biden administration won't take up their key demands: abolishing ICE and defunding the police, a concept that can range from reinvesting police resources in marginalized communities to disbanding forces altogether, they told CNN.

"There is a lot of anger and rage" over social inequity among Americans, rioter Alix Powell told CNN. And vandalism is how some people express their anger, she said.

"There's a lot of hopelessness in people my age and people I know who feel like no matter how you vote, no matter what you do, they're not listening," she said Thursday. "A riot is the language of the unheard."

"It doesn't matter who's president: Black lives don't matter, Arab lives don't matter, they don't care about us. They just don't," another rioter of Arab descent, who also wished to remain anonymous, told CNN on Thursday.

National Black leaders are counting on the new President to unify the county and enact policies that address the disparities Black people face in housing, education, jobs, health care and voter suppression, they have said. They also want Biden to undo the harm caused by President Donald's Trump offensive rhetoric toward people of color and refusal to address police brutality in the Black community.

Among the first three executive orders Biden signed on Inauguration Day was one meant to ensure racial equality and support underserved communities. Biden also has assembled the most racially diverse presidential Cabinet in US history. His Department of Homeland Security has paused deportations for 100 days, with some exceptions. And on Friday, he's set to sign executive orders that expand aid to low-income Americans.


Portland's many months of protests


As in cities across the country, protests erupted in Portland late last spring over the death of George Floyd at the hands of Minneapolis police and expanded to include demands for police accountability and prosecutorial reform in the cases of Breonna Taylor, Ahmaud Arbery, Elijah McClain and other Black victims.

The events have ranged from peaceful Black Lives Matter marches to violent riots including arson and vandalism. Some have become a target for hate groups seeking to antagonize those who come out to defend the rights of marginalized communities.

Oregon's complicated racial tensions trace to the time of the nation's founding. As late as 1854, the Oregon Constitution was amended with exclusionary language to keep Black people out of the state, according to a timeline published by Portland city officials.

The 14th Amendment, giving citizenship to Black people, passed there in 1868, two years after Congress approved it.

But it wasn't until the 1950s that Oregon began peeling back laws and rules that propped up racial discrimination in housing, schools and employment.
© Paul L/AP Protesters shield themselves from chemical irritants Wednesday evening outside the US Immigrations and Customs Enforcement building in Portland, Oregon.


#OHS

Rescuers at risk: emergency personnel face trauma and post traumatic stress symptoms

Emergency workers face suicidal thoughts and post-traumatic stress symptoms (PTSS), with emergency department and psychiatric department staff most at risk

FRONTIERS

Research News

A new study in Frontiers in Psychiatry has for the first time, demonstrated differences in the prevalence of post-traumatic stress symptoms (PTSS) in different groups of rescue workers and emergency personnel, including firefighters, police officers and psychiatric nurses. The researchers showed that the varying experiences and circumstances these workers encounter, such as handling aggressive people, working with families or dealing with deaths and suicide, are tied to varying levels of PTSS and suicidal thoughts, with emergency department staff and psychiatric nurses showing the highest levels of PTSS and suicidal thoughts out of the emergency professions studied. The findings highlight the urgent need for bespoke training and counselling services across the rescue and emergency industries, which would help staff to cope with the trauma they experience, improving their quality of life and mental wellbeing in such high-risk professions. The study was led by Dr Leila Soravia and Dr Thomas Müller at the University of Bern's Hospital of Psychiatry in Switzerland.

Rescue workers and emergency personnel often encounter traumatic events as part of their roles and are therefore at a higher risk of developing PTSD and suicidal thought patterns than the general public. Dr Soravia explains:

"Though rescue workers across different professions will often be engaged at the same event or emergency, they have very different roles and responsibilities on the scene: this can mean the stress experienced by different workers is very subjective - whether that's from dealing with deaths, working with families of victims, or being exposed to violence. The mental wellbeing training that is offered to staff to teach them how to cope with this stress and trauma also often varies across these different professions. We therefore speculated that the prominence of PTSS and other related factors would vary across different rescue workers, which has not been studied so far."

The researchers distributed an anonymous online survey to rescue workers across Bern, Switzerland, which included police officers, firefighters, ambulance personnel, emergency department staff and psychiatric nurses. All the participants were asked questions about traumatic events they had experienced before and during the course of their job, any PTSS or suicidal thoughts they experienced, and were also asked to rate how well they thought they coped with stress and PTSS.

The study found significant differences in the prevalence of PTSS between different professions, and notably, emergency department staff and psychiatric nurses featured the highest prevalence of PTSS. For individuals who demonstrated PTSS, dysfunctional coping strategies, such as alcohol abuse or avoidance of a situation or emotion related to their stress was one of the most robust predictors of their symptoms.

"The findings highlight how even the same emergency situations can affect the mental health of rescue workers differently. We urgently need profession-specific training that can improve emergency workers' abilities to cope with the stresses of their job to reduce their PTSS and enhance their quality of life in such high-risk professions," highlights Dr Soravia.

"Long term studies would help us understand the predictors of PTSS in emergency personnel - a more profound understanding of these symptoms could then be a valuable basis for mental wellbeing training and support in the future."

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ALS study reveals a unique population

Scientists discover that ALS patients in Malta do not have flaws in major ALS genes

UNIVERSITY OF MALTA

Research News

IMAGE

IMAGE: MALTESE OUT ON A SUNDAY, ON ONE OF THE BUSIEST STREETS IN VALLETTA, MALTA'S CAPITAL CITY view more 

CREDIT: SOURCE: JONATHAN BORG, TIMES OF MALTA

Malta, a sovereign microstate in the middle of the Mediterranean Sea, has no shortage of sunny beaches, honey-bricked villages and rugged countryside. Beyond its Mediterranean charm, Malta is home to a geographically and culturally isolated population whose unique genetic makeup, makes this island nation a goldmine for genetics research.

Four years ago, the University of Malta set up a national ALS Registry and Biobank to identify patients with amyotrophic lateral sclerosis (ALS) and collect data on their residence, occupation, lifestyle and environmental exposures. Blood samples donated by participants will remain stored in high-tech storage facilities at the University over many years.

ALS is a progressive neurological disease that destroys the nerves that interact with the body's muscles. The disease typically leads to complete paralysis of the body, robbing patients of their ability to walk, speak, eat and breathe. There is no cure for ALS, and eventually, the disease is fatal.

Malta's ALS Biobank is providing scientists with an invaluable resource for understanding the causes of ALS. In the first landmark study, researchers have retrieved and scrutinised the DNA from blood samples to discover flaws in genes linked to ALS.

"The DNA results caught us by surprise. The most frequently mutated ALS genes were flawless in Maltese patients," said the study's lead researcher Dr Ruben J. Cauchi, PhD, a senior lecturer at the University's School of Medicine and lead investigator at the University's Centre for Molecular Medicine and Biobanking.

Collaborating with scientists at the University Medical Centre (UMC) Utrecht in The Netherlands, University of Malta researchers found that ALS patients in Malta did not have flaws in the C9orf72, SOD1, TARDBP and FUS genes, which are known to contribute to a major number of ALS cases worldwide.

The study nonetheless revealed that compared to other European populations, a higher percentage of Maltese patients with no prior family history of ALS have harmful flaws in their DNA. Intriguingly, these occur in genes that are rarely damaged in Europeans with ALS.

"Our results underscore the unique genetics of the Maltese population, shaped by centuries of relative isolation. We also established that genetic factors play a significant role in causing ALS in Malta," added Dr Cauchi.

Right now, the research team is on the hunt for what triggers ALS in more than half of the study subjects that had no flaws in known ALS genes. Thanks to the participation of patients and healthy volunteers, Malta's ALS Biobank is rapidly growing into a precious treasure trove of data that is expected to unveil more fascinating insights on the causes of ALS in the years to come.

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Study co-authors are Rebecca Borg, Maia Farrugia Wismayer, Dr Karl Bonavia, Dr Andrew Farrugia Wismayer and Prof Neville Vassallo from the University of Malta; Dr Malcolm Vella from Mater Dei Hospital; and Dr Joke J.F.A. van Vugt, Dr Brendan J. Kenna, Dr Kevin P. Kenna, and Prof Jan H. Veldink from UMC Utrecht.

The study was funded by the University of Malta Research Excellence Fund, an Endeavour Scholarship (part-financed by the European Social Fund), an EMBO fellowship, a Malta Council for Science & Technology Internationalisation Partnership Award, ALS Malta Foundation and the University of Malta's Research Trust (RIDT).

Online courses reinforce inequalities

Gifted students improve their grades when they take online courses, whereas students in difficulty do not.

UNIVERSITÉ DE GENÈVE

Research News

With the global student community taking online courses as a result of the anti-Covid-19 measures, a study led by the University of Geneva (UNIGE) reveals that online courses deepen inequalities between gifted and less gifted students by 5%. The results of the study, which was based on data collected in 2016-2017 prior to the anti-Covid lockdown initiatives, are published in the Journal of the European Economic Association. They indicate that this learning gap between different student profiles is mainly due to their behaviour and motivation. The study gives higher education establishments worldwide practical ways to deal with lockdown or the chronic lack of space in lecture theatres, including via co-educational curricula.

To gain insight into the impact of online courses on the success of university students (and to measure the interest they generate), 1,459 first-year students at UNIGE took part in a study run by UNIGE's Geneva School of Economics and Management (GSEM). Students were randomly offered online courses (while others, as a check, were not) to study their eight compulsory programmes covering subjects such as mathematics and economics. The content of the courses was then linked to specific exams in order to assess their level of knowledge. Every student had the opportunity to attend face-to-face classes if they wanted to. The data for the study was collected before the Covid-19 health crisis.

The inequality gap is widening

The results of the study show that online courses improve exam results for high-potential students by 2.5%. At the same time, however, the results for students with learning difficulties decrease by 2%. "Access to online education seems to widen the gap between gifted and less gifted students," begins Michele Pellizzari, GSEM co-director and co-author of the study. "That's a fact that universities around the world need to take note of, as the coronavirus is accelerating the shift to online learning."

The study found that students adopt different patterns of behaviour when it comes to online course options depending on their learning abilities. When the weather is bad, for example, students who have the best results often choose to study by themselves at home, while students who are not so well equipped go the extra mile to attend face-to-face classes. Furthermore, students with high potential choose streaming when it is offered, while students in difficulty once more prefer in-person classes. The authors argue that these different behaviours create educational inequalities when streaming is introduced.

Limited appetite

In overall terms, if university students have the choice, they prefer to attend face-to-face classes. They only opt for the online solution when confronted with unexpected situations caused by illness or even bad weather. Accordingly, offering streaming courses only reduces face-to-face participation by 8%. "That means these figures," continues the researcher, "don't solve the current problems of overcrowded lecture theatres in higher education."

The study helps to show the impact of e-learning on results as well as emphasising its limits. This data is useful for higher education institutions around the world given the current health crisis and shortage of classroom space. The article also offers effective blended learning solutions, where streaming complements face-to-face teaching. "At the same time, more data is needed so we can draw definitive conclusions about 100% online courses," concludes Professor Pellizzari.

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This study was carried out in collaboration with the EPFL and the University of St. Gallen.

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Could "Power Walking" fuel the energy revolution? India is ready to step up

A survey finds that energy generated from footsteps could help tackle the country's reliance on coal

DE GRUYTER

Research News

India has an energy problem. It currently relies heavily on coal and consumer demand is expected to double by 2040, making its green energy targets look out of reach. Part of the solution could come from harvesting energy from footsteps, say Hari Anand and Binod Kumar Singh from the University of Petroleum and Energy Studies in Dehradun, India. Their new study, published in the De Gruyter journal Energy Harvesting and Systems, shows that Indian attitudes towards power generated through piezoelectric tiles are overwhelmingly positive.

Cities like Delhi and Mumbai are famously crowded, especially at railway stations, temples and big commercial buildings. This led researchers to wonder whether piezoelectric tiles, which produce energy through mechanical pressure, could turn this footfall into something useful.

Piezoelectric tiles are made using special materials, such as crystals and ceramics, in which electric charge builds up when mechanical stress is applied - such as a foot pressing down.

Anand and Singh ran a survey in which they explored how people in India view the reliability of their household power and what their attitudes were towards generating their own electricity. They also asked participants how much they walked on average and whether they would consider implementing piezoelectric tiles into their homes.

They found that more than one in five people suffered frequent power-cuts in their area, highlighting the potential benefits of household energy generators such a piezoelectric tiles. Around 40% of respondents said they walked for more than three hours a day, and roughly 70% were willing to produce their own electricity using their feet.

The researchers also suggest that while household tiles can be used to solve problems of energy reliability and generation for individual families, piezoelectric tiles will also be a good investment for public or commercial areas with heavy footfall. They estimate that for the cost of a single 1 kW solar panel, three times more power could be generated a year using piezoelectric tiles.

"As a gadget, the piezoelectric tiles can be attractive home décor that will also help in producing household electricity," says Singh. "In this paper the output generated through the piezoelectric tiles has been studied in comparison with solar power generation."

As the efficiency and durability of piezoelectric tiles improve and as the need for green solutions becomes more urgent, the researchers predict that this type of energy production will experience a boom on the green energy market.

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The paper was published online ahead of print here: https://doi.org/10.1515/ehs-2020-0002

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Benvitimod cream: a new topical treatment for plaque psoriasis

New non-steroidal topical drug benvitimod proven to be safe and effective for plaque psoriasis in a phase III clinical trial in China

CACTUS COMMUNICATIONS

Research News

IMAGE

IMAGE: THE NOVEL NON-STEROIDAL CREAM, BENVITIMOD, CAN SAFELY AND EFFECTIVELY TREAT PSORIASIS OVER THE LONG TERM WITHOUT SIDE-EFFECTS view more 

CREDIT: PEXELS

Psoriasis is a chronic inflammatory skin disease characterized by erythematous (red) patches and plaques. In some patients, psoriasis may be associated with comorbidities such as arthritis, obesity, diabetes, cardiovascular diseases, hyperlipidemia, or depression. Psoriasis lesions can occur on the scalp and face, in addition to all other areas of the body, causing considerable physical discomfort and psychosocial trauma from the stigma surrounding appearance defects.

More than 90% of patients with psoriasis have what is called psoriasis vulgaris, which is characterized by plaques, and less than 5% have the other varieties: arthritic psoriasis, pustular psoriasis, and erythrodermic psoriasis. The most common treatments for mild to moderate plaque psoriasis are topical corticosteroids and vitamin D3 analogs.

However, the long-term use of these topical steroids often causes various side-effects such as skin atrophy, hypo- or hyper-pigmentation, telangiectasia, and skin infections. And the long-term use of vitamin D3 analogs may add the requirement of interventions to regulate calcium and phosphate metabolism. These effects on the body are significant and there is a need for novel topical and systemic treatments for psoriasis.

In a study recently published in Chinese Medical Journal, scientists from renowned research institutes and hospitals across China, led by Prof. Jian-Zhong Zhang from Peking University People's Hospital, have met this need in part. They have reported that benvitimod, a novel non-steroid topical drug, is effective and safe for treating plaque psoriasis.

Speaking of their research journey, Prof. Zhang says, "Benvitimod (also known as tapinarof) is a small molecule that was first isolated from the bacterium Photorhabdus luminescens and was synthesized by late Genhui Chen and his team from Beijing Wenfeng Tianji Pharma. It took more than 20 years to study the mechanism of action, come up with the formulation, and evaluate the efficacy and safety of this compound in patients with psoriasis. It was hard work indeed."

In their study, Prof. Zhang and his colleagues carried out a double blinded, placebo controlled, phase III clinical trial in twenty-three dermatological centers in China to evaluate the safety and efficacy of topical benvitimod cream in patients with mild-to-moderate plaque psoriasis.

Six hundred and eighty-six adult patients with mild to moderate plaque psoriasis were included in this study. Patients were randomized to receive 1% benvitimod cream, 0.005% calcipotriol ointment--a standard treatment for plaque psoriasis--or a similar-looking "placebo." They were treated for 12 weeks. The efficacy of benvitimod was assessed at the end of the treatment period.

Of the patients receiving treatment with benvitimod cream, 50.4% achieved a psoriasis area and severity index (PASI) score of 75 at 12 weeks, which indicates a 75% or greater decrease in psoriasis size and severity compared to pre-treatment levels. In contrast, PASI 75 was achieved in only 38.5% and 13.9% of patients receiving calcipotriol ointment and placebo, respectively. Similarly, a significantly higher proportion of patients who received benvitimod cream (66.3%) achieved a static physicians' global assessment (sPGA) score of 0 or 1 (which indicate very low disease severity) compared to those who were put on placebo (33.5%).

This phase III trial also showed that the benvitimod cream was well tolerated. The most common side-effects were only mild irritation and itching at the site of application and these symptoms resolved spontaneously in most patients. No serious systemic side-effects were found.

Prof. Zhang remarks, "The results of this phase III trial are encouraging. The benvitimod cream can soon be a new treatment option for Chinese patients with plaque psoriasis. Given that most patients with psoriasis have plaque psoriasis, this will have a significant impact in terms of reducing the psoriasis disease burden in the country."

Perhaps, in time, it can become a standard method of psoriasis management all over the world.

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Reference

Titles of original papers: A double-blind, randomized, placebo- and positive-controlled phase III trial of 1% envitimod cream in mild-to-moderate plaque psoriasis
Journal: Chinese Medical Journal
DOI: 10.1097/CM9.0000000000001221