Friday, March 12, 2021

 

The COVID-19 pandemic has caused changes to people's wellbeing around the world

A decrease in physical activity during the pandemic was associated with poorer perceived physical and mental health

UNIVERSITY OF JYVÄSKYLÄ - JYVÄSKYLÄN YLIOPISTO

Research News

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IMAGE: THERE HAS BEEN GREAT VARIABILITY IN PEOPLE'S PHYSICAL ACTIVITY DURING COVID-19 PANDEMIC. view more 

CREDIT: UNIVERSITY OF JYVÄSKYLÄ

According to an international study published in Frontiers in Psychology, people around the world have reported changes in their physical activity levels, wellbeing, and eating habits during the first stages of the COVID-19 pandemic. A decrease in physical activity during the pandemic was associated with poorer perceived physical and mental health. Reduced exercise was also associated with perceptions of weight gain and decreased sleep.

More than a thousand individuals from several countries with different containment measures participated in an online survey that explored changes in physical activity, eating, sleep, physical and mental health, and wellbeing during the first lockdown phases of the COVID-19 pandemic. The study was conducted in collaboration between the Faculty of Sport and Health Sciences at the University of Jyväskylä, the University of Wolverhampton and the University of Northampton in the United Kingdom.

Comparisons across countries revealed significant differences in physical health, with Finnish participants reporting higher values and participants residing in the UK indicating poorer health.

There was great variability in participants' physical activity. Some individuals reported a high increase in physical activity while others reported a great decrease.

"Increased physical activity was associated with better physical health as rated over the past week along with increased wellbeing and sleep," says Sport and Exercise Psychology Lecturer Montse Ruiz from the Faculty of Sport and Health Sciences at the University of Jyväskylä, Finland. "In contrast, reduced physical activity was related to lowest mental health, represented by more personal and emotional problems, and a signi?cant increase in eating and weight."

Participants living in Latin American countries perceived themselves to have poorer mental health, compared to South Koreans who indicated being significantly less affected by personal or emotional problems. Filipino participants reported higher sleep and eating scores compared to the other countries.

"Our findings indicate that irrespective of country of residence or age, participants reporting reduced physical activity typically experienced poorer physical and mental health along with diminished wellbeing," Ruiz says. "Reduced exercise was also associated with perceptions of weight gain and decreased sleep."

To minimize the spread of the SARS-CoV-2 virus, a range of containment measures, including the restriction of people's movement, were implemented in several countries. As a result, changes in peoples' behaviors were observed, such as the well-documented instances of panic buying and stockpiling of household items.

"As the containment measures related to COVID-19 continue, our findings highlight the importance of exercise in maintaining good physical and mental health," Ruiz says. "As such, we encourage individuals to find ways of incorporating physical activity into their day where possible."

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Ecosystem restoration is a pressing issue in fragmented rainforest

UNIVERSITY OF HELSINKI

Research News

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IMAGE: AIRBORNE LIDARS ARE USUAL AIRPLANES FLYING ACROSS THE STUDIED FORESTS WITH A SENSOR ATTACHED TO THEM. view more 

CREDIT: PHOTO: AIRCRAFT NERC, LANDSCAPE BENJAMIN BLONDER. IMAGE PROCESSING JANI NÄRHI

In light of the United Nations (UN) declaration that 2021-2030 is the UN Decade on Ecosystem Restoration, a group of scientists voice concerns about restoration in heavily fragmented landscapes under a hotter and drier future scenario.

Poor recovery of small fragments will end up costing management and wider society later down the line. Millions are invested in setting aside patches, but management is then weak and costly.

Rainforests turn into oil palm plantations

The past 40 years in Southeast Asia have seen about 50% of lowland rainforests converted to oil palm and other plantations, and much of the remaining forest heavily logged.

Little is known about how fragmentation influences recovery and whether climate change will hamper restoration.

"Here, we use repeat airborne LiDAR surveys spanning the hot and dry 2015-16 El Niño Southern Oscillation (ENSO) event to measure canopy height growth across 3,300 ha of regenerating tropical forests spanning a logging intensity gradient in Malaysian Borneo", says postdoctoral researcher Matheus Nunes from the University of Helsinki, lead author of the paper recently published in Nature Communications.

Repeat high-density airborne LiDAR across the human-modified forests of Borneo provided a unique perspective on the regrowth of forests during the 2015-2016 ENSO and the environmental controls on the canopy. Regeneration of logged forests was still positive during the hot and dry ENSO in Borneo when the highest temperatures and the highest VPD exceeded 2.1 °C and 140% the local long-term average during non-El Niño years. The results demonstrate that regenerating logged forests in this landscape - which contain a high abundance of pioneer tree species with acquisitive traits - continued to grow, despite the high temperatures and water demand in these logged forests.

However, the predictions revealed in the paper show that environmental controls were key to modulating regrowth at the landscape level.

Fragmentation effects increased exponentially with proximity to oil palm plantations, which is consistent with the long-term fragmentation effects that lead to tree mortality and lower productivity.

"Additionally, we demonstrate that the position of fragmented forests across the landscape was also a predictor of forest growth, with valleys and riparian forests showing higher canopy growth compared to those on hilltops during the El Niño", says Nunes.

Suggestions to the Roundtable for Sustainable Oil Palm

Oil palm companies that have joined the Roundtable for Sustainable Oil Palm are committed to the protection of high conservation value forests along rivers and on steep slopes within their estates.

"Our results suggest buffers have to be wide (at least 40 m on each side of the river) to ensure the interior of the strip retains a stable canopy height during droughts", says Nunes.

This is twice the width of what is currently required by law in Sabah, Malaysia. If designed and protected appropriately, riparian reserves in oil palm estates support regrowth with potential positive consequences for the global carbon cycle and for ecosystem function.

The results also demonstrate that small, fragmented patches of regenerating logged forests left on hilltops will be slow to recover due to lower water availability, particularly as El Niño events are becoming more frequent as a result of climate change. Fragmentation in these regenerating logged forests leads to consistent canopy loss within 110 m from oil palm plantations. These results suggest that small patches of logged forests on hilltops will not recover, reflecting the intertwined effects of fragmentation and climate.

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Reference:

Recovery of logged forest fragments in a human-modified tropical landscape during the 2015-16 El

Niño: Matheus Henrique Nunes, Tommaso Jucker, Terhi Riutta, Martin Svátek, Jakub Kvasnica, Martin Rej�ek, Radim Matula, Noreen Majalap, Robert M. Ewers, Tom Swinfield, Rubén Valbuena, Nicholas R. Vaughn, Gregory P. Asner and David A. Coomes

Link to Nature Communications https://www.nature.com/articles/s41467-020-20811-y

https://doi.org/10.1038/s41467-020-20811-y


 

Making the role of AI in medicine explainable

Analysis system for the diagnosis of breast cancer


CHARITÉ - UNIVERSITÄTSMEDIZIN BERLIN

Research News

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IMAGE: DETECTION OF TUMOR-INFILTRATING LYMPHOCYTES (TILS) USING EXPLAINABLE AI. THE AI-TECHNIQUE IS USED TO GENERATE A HEATMAP SHOWING TILS (RED) AND OTHER TISSUES AND CELLS (BLUE AND GREEN). view more 

CREDIT: IMAGE: KLAUSCHEN/CHARITÉ

Researchers at Charité - Universitätsmedizin Berlin and TU Berlin as well as the University of Oslo have developed a new tissue-section analysis system for diagnosing breast cancer based on artificial intelligence (AI). Two further developments make this system unique: For the first time, morphological, molecular and histological data are integrated in a single analysis. Secondly, the system provides a clarification of the AI decision process in the form of heatmaps. Pixel by pixel, these heatmaps show which visual information influenced the AI decision process and to what extent, thus enabling doctors to understand and assess the plausibility of the results of the AI analysis. This represents a decisive and essential step forward for the future regular use of AI systems in hospitals. The results of this research have now been published in Nature Machine Intelligence*.

Cancer treatment is increasingly concerned with the molecular characterization of tumor tissue samples. Studies are conducted to determine whether and/or how the DNA has changed in the tumor tissue as well as the gene and protein expression in the tissue sample. At the same time, researchers are becoming increasingly aware that cancer progression is closely related to intercellular cross-talk and the interaction of neoplastic cells with the surrounding tissue - including the immune system.

Although microscopic techniques enable biological processes to be studied with high spatial detail, they only permit a limited measurement of molecular markers. These are rather determined using proteins or DNA taken from tissue. As a result, spatial detail is not possible and the relationship between these markers and the microscopic structures is typically unclear. "We know that in the case of breast cancer, the number of immigrated immune cells, known as lymphocytes, in tumor tissue has an influence on the patient's prognosis. There are also discussions as to whether this number has a predictive value - in other words if it enables us to say how effective a particular therapy is," says Prof. Dr. Frederick Klauschen of Charité's Institute of Pathology.

"The problem we have is the following: We have good and reliable molecular data and we have good histological data with high spatial detail. What we don't have as yet is the decisive link between imaging data and high-dimensional molecular data," adds Prof. Dr. Klaus-Robert Müller, professor of machine learning at TU Berlin. Both researchers have been working together for a number of years now at the national AI center of excellence the Berlin Institute for the Foundations of Learning and Data (BIFOLD) located at TU Berlin.

It is precisely this symbiosis which the newly published approach makes possible. "Our system facilitates the detection of pathological alterations in microscopic images. Parallel to this, we are able to provide precise heatmap visualizations showing which pixel in the microscopic image contributed to the diagnostic algorithm and to what extent," explains Prof. Müller. The research team has also succeeded in significantly further developing this process: "Our analysis system has been trained using machine learning processes so that it can also predict various molecular characteristics, including the condition of the DNA, the gene expression as well as the protein expression in specific areas of the tissue, on the basis of the histological images.

Next on the agenda are certification and further clinical validations - including tests in tumor routine diagnostics. However, Prof. Klauschen is already convinced of the value of the research: "The methods we have developed will make it possible in the future to make histopathological tumor diagnostics more precise, more standardized and qualitatively better."

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*Binder A et al. Morphological and molecular breast cancer profiling through explainable machine learning. Nat Mach Intell (2021), doi: 10.1038/s42256-021-00303-4


CAPTION

Breast cancer tissue sample (hematoxylin and eosin staining).

CREDIT

Image: Klauschen/Charité

School closures may have wiped out a year of academic progress for pupils in Global South

As much as a year's worth of past academic progress made by disadvantaged children in the Global South may have been wiped out by school closures during the COVID-19 pandemic, researchers have calculated.

UNIVERSITY OF CAMBRIDGE

Research News

As much as a year's worth of past academic progress made by disadvantaged children in the Global South may have been wiped out by school closures during the COVID-19 pandemic, researchers have calculated.

The research, by academics from the University of Cambridge and RTI International, attempts to quantify the scale of learning loss that children from poor and marginalised communities in the Global South may have experienced, and the extent to which home support and access to learning resources could ameliorate it. While it is known that the education of these children has suffered disproportionately during the pandemic, it is much harder to measure exactly how much their academic progress has been impeded while schools have been closed.

The researchers used data from Ghana to model the likely impact of closures for children in remote and deprived parts of that country. They found that on average, 66% of the learning gains made in foundational numeracy during the academic year are lost during three months out of school. The outcome is, however, far worse for children without adequate home learning resources or support.

The authors suggest these findings provide a glimpse of a much wider pattern of learning loss that is being experienced by millions of disadvantaged children around the world.

Co-author Professor Ricardo Sabates, from the REAL Centre in the University's Faculty of Education, said: "Despite teachers' best efforts, we know school closures have held up, or reversed, the progress of millions of children. This study is one approach to estimate how much learning could have been lost, and how much worse this may have been for children from disadvantaged settings."

"These figures represent an estimate of learning loss for children who spent 3 to 4 months out of school. We expect that as schools remained closed for longer, losses could be higher. We also acknowledge the important support that many families and communities provided with supplementary learning, which may have in turn limited the potential loss overall."

The study built on earlier research that highlighted the significant learning losses that occur when certain groups of children in developing countries move from one academic year to the next, particularly those who change language of instruction, and disadvantaged girls.

The researchers used data charting the progress of more than 1,100 students on Ghana's Complementary Basic Education (CBE) programme between 2016 and 2018. This programme supports children aged eight to 14 who would not normally attend school, providing them with education in their own language and at flexible times. On completion, students are encouraged to enrol at a local government school, but the start of that school year occurs after a three-month gap, during which they receive no education.

The researchers compared participants' scores in foundational maths tests at four stages: when they started the CBE, when they finished, when they joined a government school, and after their first year in government school. They also accessed data about how much home learning support the students had - for example, whether they had books at home, or could seek help from an adult when struggling with homework.

During the CBE programme, the students' test scores improved, on average, by 27 percentage points. When they were tested again after the three-month gap, however, their scores had reduced by an average of 18 percentage points. Two-thirds of the gains these students had made during the previous academic year were therefore lost while they were out of school. The researchers argue that this is an upper estimate of the expected scale of loss during an equivalent period of school closures due to COVID-19. Fortunately, during the pandemic community efforts to enhance learning may have mitigated this effect for some children.

In spite of this, they also found that the basic learning loss was compounded among children who lacked support to study at home. For example:

* Children without access to reading and learning resources at home (such as books) experienced a learning loss above 80%.

* Children who said that they never asked adults in their household for help experienced a learning loss of around 85%.

Encouragingly, the study showed that in the first year of formal education, students not only recouped their learning loss, but improved, while the attainment gap between more and less advantaged students narrowed.

In many countries, however, it is becoming clear that many disadvantaged students - especially marginalised groups such as disabled children and many girls - are not returning to school. Therefore, the researchers suggest supporting access to diverse forms of education for students from less-advantaged backgrounds. There is evidence to show that community-based programmes, for example, can enhance a range of learning skills for these children. "Learning at home and in communities has to be reimagined if rapid gains are to be achieved as we continue to face the COVID-19 situation," the authors say.

The pattern of learning loss charted in Ghana may also apply far beyond the Global South. "This is an international challenge," said co-author Emma Carter, also from the REAL Centre. "In Europe and the US, children from lower socio-economic backgrounds will similarly be experiencing severe learning loss. The levels of attainment may differ between countries, but it is highly likely that the pattern of loss remains."

The evaluation data used in the study was commissioned and funded by FCDO Ghana. The research is published in the International Journal of Educational Development.

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Ice skating and permafrost

Investigation of thin liquid films at interfaces between ice and clay materials

MAX PLANCK INSTITUTE FOR POLYMER RESEARCH

Research News

For ice, so-called "surface melting" was postulated as early as the 19th century by Michael Faraday: Already below the actual melting point, i.e. 0 °C, a thin liquid film forms on the free surface because oft he interface between ice and air. Scientists led by Markus Mezger, group leader at the Max Planck Institute for Polymer Research (department of Hans-Jürgen Butt) and professor at the University of Vienna, have now studied this phenomenon in more detail at interfaces between ice and clay minerals.

In nature, this effect is particularly interesting in permafrost soils - i.e. soils that are permanently frozen. About a quarter of the land area in the northern hemisphere is covered by permafrost. These are composed of a mixture of ice and other materials. Microscopically thin platelets were formed over geological time by the weathering of clay minerals. Similar to a sponge, a lot of water can enter the narrow slit pores between the thin platelets, be stored there, and freeze. Therefore, there is a lot of contact area between ice and clay minerals. For every gram of clay mineral, there are about 10 square meters of surface area! This causes a comparatively high proportion of liquid water in the interfacially induced melt layer already below 0 °C.

The researchers have now investigated how fast the water molecules move in the thin melt layer at the boundary between ice and clay mineral. This value, known as "self-diffusion," is directly linked to the viscosity of the water. For three different minerals, it has been shown that the viscosity of water in the interface-induced melt layer is sometimes significantly higher than that of ordinary water - i.e., the molecules are limited in their ability to move because the layer is more viscous. These results may help to better understand various phenomena in the future, such as the mechanical stability of permafrost, the transport of plant nutrients and pollutants, and geochemical reactions such as ion exchange processes at ice/mineral interfaces.

For their measurements, the Mainz scientists collaborated with partners at the research reactors of the TU Munich and the Institut Laue-Langevin in Grenoble, France. The neutrons generated in the reactors there strike the sample at a certain speed. Similar to a ball bouncing back from a vehicle moving toward it at a higher speed, velocity measurements of the neutrons scattered from the sample allow conclusions to be drawn about the motion of the water molecules in the interface-induced premelting layer.

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The results have now been published in the journal Angewandte Chemie - International Edition.


UConn researcher finds 'Goldilocks problem' in child welfare decision-making

UNIVERSITY OF CONNECTICUT

Research News

When something bad happens to a child, the public and policy response is swift and forceful.

How could this have happened?

What went wrong?

What do we do to make sure it never happens again?

When a family becomes erroneously or unnecessarily enmeshed in the child welfare system, that burden is largely invisible - a burden borne mostly by the family itself.

In both situations, the fault for the systemic failure is often placed on the caseworker - overburdened, under-resourced, and forced to make quick and critical judgments about the risk of harm or neglect to children.

But, according to new study coauthored by a researcher in the UConn School of Social Work, a major tool used in child welfare decision-making - and the way agencies try to implement it - may be part of the problem.

"I think it seems appealing to have a consistent way to do something," says Megan Feely, an assistant professor of social work who specializes in child welfare and child maltreatment prevention. "It's when you get into the details that it becomes kind of murky."

In their study - recently published in the journal, Social Service Review - Feely and coauthor Emily Bosk, an assistant professor at the Rutgers University School of Social Work, examined the application of the Structured Decision-Making Model's Risk Assessment in two states.

"What to do with children who need to be safe, and families who may need help keeping their children safe, seem like some of the most important decisions a state will make," says Feely, "and it's really sort of shocking how little attention has been given to how these decisions are made - these incredibly, incredibly important decisions."

Commonly called the "RA," the risk assessment is an actuarially-based prognostic tool that provides a checklist for child welfare workers to use to help assess a family's future risk. It asks questions -- Has the family been involved in child welfare before? Have they had an allegation of neglect? Does the primary caretaker have a substance use problem? Do they have a current or past mental health problem? Are the children medically fragile? - and then categorizes the family as low, medium, high, or intensive risk, based on the worker's responses.

The RA is considered the gold standard in child welfare decision-making, developed with the goal of providing a level of standardization and predictability. It was intended to be used in conjunction with workers' clinical judgement but designed to eliminate some of the most glaring problems with clinical decision-making, such as individual variation in the interpretation of the same set of facts, implicit bias, and lack of knowledge about empirically established risk factors.

"The RA is premised on the idea that when workers follow it, different individuals are reasonably likely to come to the same conclusion about case actions," Bosk and Feely wrote. "No longer will outcomes be random - that is, contingent on which worker a family is assigned."

For their study, Bosk and Feely examined the RA's use - reviewing policies and interviewing caseworkers and their supervisors - and found drastically different applications of the assessment between the two states at the organizational level. In the first, the application of the RA has been mandated by the legislature and was used strictly and in place of clinical judgment. In the other, while the RA was always completed, it was not a significant factor in decision-making, with clinical judgment typically driving decisions.

"We call this 'the Goldilocks problem,' because one state essentially totally privileges the RA score," Feely says, "so it's a too tight interpretation of what to do with it. And in the other, most workers don't really use it, so it's an overly loose interpretation of what to do with it and how to integrate it into clinical judgment. There's no middle point."

In the so-called "tight state," workers explained they were unable to use anything other than the RA to make case determinations, which was not the intended application of the assessment by its developers. Clinical assessment was discouraged and, because of the rigidity of the framework, some workers would intentionally circumvent the RA - changing scores to either increase or decrease the predicted risk - in order to achieve a case trajectory that better matched their otherwise disregarded clinical judgment.

By contrast, in the so-called "loose state," workers were required to complete the RA, but it had little to no role in case decision-making, with the majority of workers relying on their clinical judgements and consultations with their supervisors to decide case trajectories. While the workers had significantly more flexibility in their decision making, the researchers found, the potentially systemizing and standardizing effect of the RA was eliminated.

The problem, Feely says, comes down to a flaw in the RA itself: While the developers intended for the RA to be used in conjunction with clinical judgment, they never provide any guidance or methodology on how to integrate the two. The propensity is to blame the workers, or the agencies, for the RA's shortcomings, she says, but workers consistently found the tool to be problematic, and the study validates those concerns.

"Without guidance, it's not clear how to integrate them, exactly, because it's not another piece of more qualitative information, which we would use in clinical judgment, but a hard number," Feely says. "We found that organizational context really matters for the application of the RA, and that because it's not specified in the model, organizations are responsible for figuring out how to integrate the score with clinical judgment themselves."

While that led to some workers in the "tight state" manipulating the RA, it also led workers to escalate cases involving families that, through clinical judgement, would likely not have been considered at risk. Feely said that unnecessarily high rates of child welfare involvement, particularly in marginalized communities or communities with many Black, Indigenous, or other people of color, contributes to the overall sense that the system is unfair.

"You can see how frustrating it would be if your child had autism, or was categorized as having behavioral or mental health issues, and you were on antidepressants, and then all of a sudden you're labeled as at risk," she says. "You can't do anything about those things. You can't fix them. You're not going to go off your antidepressants, because that obviously would make it worse."

She continues, "It feels like the conservative option is to err on the side of having more false positives, where people that are really not at risk are misidentified as at risk. But there are real downsides to that, and I think that, in child welfare, we're seeing a sort of paralleling with some of the attention that's on police - there are longer-term big consequences when we keep getting it wrong, because people don't trust the system."

While a clinical-based approach offers more nuance, she says, it also loses what could make the process more consistent. As the RA and other prognostic tools and their potential use in child welfare situations are being discussed, Feely said that this study offers a cautionary tale that should encourage policymakers to be wary of trusting a tool more than is warranted.

"A main issue is really having a more open discussion of how these sort of probability-based tools should be included into the context of clinical decision-making," she says. "I think that the move toward trying to incorporate more evidence and a more scientific base in social services, is positive, but I think it has to be really carefully balanced with the limits of that science. Overestimating the science, and the veracity of it, and its ability to be applicable in a particular situation, can be just as problematic for families and society as under-using it."


 

COVID-19 testing in schools complex but doable, worth the effort -- RAND study

RAND CORPORATION

Research News

A RAND Corporation report funded by The Rockefeller Foundation shows that COVID-19 testing can be effectively integrated into K-12 schools' pandemic response plans, helping families and staff feel more comfortable with in-person instruction.

The report found that even for well-resourced districts and schools, launching a COVID-19 testing program was a major undertaking that required access to rapid-turnaround tests, additional staffing or strong partners for logistical support, technical assistance for the design and execution of testing programs, and a strategy for successfully engaging the school community to participate in testing.

"Our interviews with K-12 schools show that COVID-19 testing is complex, but doable," said Laura Faherty, lead author and a physician policy researcher at nonprofit, nonpartisan RAND. "Many early adopters found it critical to partner with local public health departments, local health systems, their peers and testing vendors to launch feasible COVID-19 testing programs. But even with strong partnerships in place, school and district leaders described just how much effort it takes to make a testing program run smoothly. They described being 'hungry' for guidance and in need of a lot of technical assistance."

Researchers examined the experiences of schools and districts that were early adopters of COVID-19 testing in Fall 2020, including insights from a national scan of schools as well as more than 80 interviews with K-12 school and district leaders in December 2020.

According to the report, COVID-19 testing programs were more often implemented in public and independent schools with access to resources such as expert advice, sufficient funding and strong local partnerships.

Schools encountered varying degrees of hesitation around testing and used several strategies to encourage participation. Privacy concerns were common: Staff and parents worried their health information could be shared with others. Members of school communities expressed concern about how their test samples would be used. Another barrier to engaging their communities in testing was doubt about the actual risk posed by COVID-19.

"To give their communities peace of mind to return to in-person learning, schools often started small, using a pilot period to work out many of the details before fully launching," said Benjamin Master, co-leader of the project and a policy researcher at RAND. "The most scalable testing models that we identified involved districts that were able to access expert technical support and partners who could help manage the logistics of testing."

The report provides recommendations for how schools can develop, and policymakers can support, effective COVID-19 testing programs. Among them:

  • expand funding to ensure schools can access tests, hire additional staff and contract with vendors as needed to implement testing
  • continue to invest in research and development of testing solutions that are convenient for schools to use
  • provide incentives such as paid sick leave for teachers and families to participate in testing and isolate as needed
  • promote the use of standardized metrics and data platforms to support decisionmaking
  • provide resources to strengthen state and local health departments so they're fully equipped to help schools design testing programs and respond to positive tests.

The Rockefeller Foundation's funding for the report is part of its portfolio of work aimed at disseminating lessons learned so far about the use of COVID-19 testing to help facilitate school reopening.

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Other authors of the report, "COVID-19 Testing in K-12 Schools: Insights from Early Adopters," are Elizabeth Steiner, Julia Kaufman, Zachary Predmore, Laura Stelitano, Jennifer Leschitz, Brian Phillips, Heather Schwartz and Rebecca Wolfe.

RAND Health Care promotes healthier societies by improving health care systems in the United States and other countries. RAND Education and Labor is dedicated to improving education and expanding economic opportunities for all through research and analysis. Its researchers address key policy issues in U.S. and international education systems and labor markets, from pre-kindergarten to retirement planning.

New tool makes students better at detecting fake imagery and videos

UPPSALA UNIVERSITY

Research News

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IMAGE: RESEARCHERS AT UPPSALA UNIVERSITY HAVE DEVELOPED A DIGITAL SELF-TEST THAT TRAINS USERS TO ASSESS NEWS ITEMS, IMAGES AND VIDEOS PRESENTED ON SOCIAL MEDIA. view more 

CREDIT: THOMAS NYGREN

Researchers at Uppsala University have developed a digital self-test that trains users to assess news items, images and videos presented on social media. The self-test has also been evaluated in a scientific study, which confirmed the researchers' hypothesis that the tool genuinely improved the students' ability to apply critical thinking to digital sources.

The new tool and the scientific review of it are part of the News Evaluator project to investigate new methods of enhancing young people's capacity for critical awareness of digital sources, a key component of digital literacy.

"As research leader in the project, I'm surprised how complicated it is to develop this type of tool against misleading information - one that's usable on a large scale. Obviously, critically assessing digital sources is complicated. We've been working on various designs and tests, with major experiments in school settings, for years. Now we've finally got a tool that evidently works. The effect is clearly positive and now we launch the self-test on our News Evaluator website http://www.newsevaluator.com, so that all anyone can test themselves for free," says Thomas Nygren, associate professor at Uppsala University.

The tool is structured in a way that allows students to work with it, online, on their own. They get to see news articles in a social-media format, with pictures or videos, and the task is to determine how credible they are. Is there really wood pulp in Parmesan cheese, for instance?

"The aim is for the students to get better at uncovering what isn't true, but also improve their understanding of what may be true even if it seems unlikely at first," Nygren says.

As user support, the tool contains guidance. Students can follow how a professional would have gone about investigating the authenticity of the statements or images - by opening a new window and doing a separate search alongside the test, or doing a reverse image search, for example. The students are encouraged to learn "lateral reading" (verifying what you read by double checking news). After solving the tasks, the students get feedback on their performance.

When the tool was tested with just over 200 students' help, it proved to have had a beneficial effect on their ability to assess sources critically. Students who had received guidance and feedback from the tool showed distinctly better results than those who had not been given this support. The tool also turned out to provide better results in terms of the above-mentioned ability than other, comparable initiatives that require teacher participation and more time.

Apart from practical tips such as opening a new search tab, doing reverse image searches and not always choosing the search result at the top of the hit page (but, rather, the one that comes from a source you recognise), Nygren has a general piece of advice that can help us all become more critically aware in the digital world:

"Make sure you keep up to date with information and news from trustworthy sources with credible practices of fact-checking, such as the national TV news programmes or an established daily newspaper. It's difficult and arduous being critical about sources all the time."

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The News Evaluator project is a collaboration among the Swedish non-profit organisation Public & Science (Vetenskap & Allmänhet, VA), Uppsala University and RISE Research Institutes of Sweden. It is funded by Vinnova (Sweden's innovation agency) and Uppsala University.

Link to the tool: http://www.newsevaluator.com


Unveiling the cause of onion center rot

CARL R. WOESE INSTITUTE FOR GENOMIC BIOLOGY, UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

Research News

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IMAGE: PANTAPHOS, WHICH IS PRODUCED BY THE PLANT PATHOGEN PANTOEA ANANATIS, IS RESPONSIBLE FOR CAUSING ONION CENTER ROT. view more 

CREDIT: ALEX POLIDORE

Since 1983, the bacteria Pantoea ananatis has been known to infect several important crops including onions, rice, and corn. It was unclear, however, what molecules were involved. A new study, published in mBio, has identified one of the culprits: pantaphos. Intriguingly, the researchers have discovered that pantaphos can also act as an herbicide and it is toxic to glioblastoma cells, making it an exciting candidate for agricultural and biomedical applications.

"Herbicide resistant weeds are an issue in agriculture," said William Metcalf (MMG leader), a professor of microbiology. "Unfortunately, there hasn't been a new class of herbicide for over 30 years. If we can understand how pantaphos causes onion rot, we can solve a big problem."

Scientists at Cornell University had previously compared the disease-causing strains of P. ananatis to other innocuous strains. They identified a group of genes, designated as hvr, that were responsible for causing onion rot. The researchers in the current paper were inspired by these studies, and they subsequently identified which molecules were produced by these genes and found pantaphos.

"We can inject onions with purified pantaphos and cause onion rot. The injected onions start rotting, and become gross and mushy. It was exciting to see," said Alexander Polidore, a PhD student in the Metcalf lab. "Additionally, bacteria that cannot synthesize this molecule cannot cause onion rot, which means that it is necessary to cause the infection."

"If we can fully understand how pantaphos is made by the bacteria, we can identify multiple steps of intervention. If we can stop any one of those processes, we can get rid of onion rot," Metcalf said.

Intriguingly, pantaphos has also shown promise as an effective herbicide. "I compared pentaphos to Liberty and Roundup, which are common herbicides, and it was just as good--or even better--against typical weeds such as mustard seedlings," Polidore said.

An important requirement for an herbicide is that it kills weeds, but remains non-toxic to other animals, including humans. Therefore, the researchers tested the toxicity of pantaphos against other organisms. "Although it does not affect other bacteria and fungi, we found that it is moderately toxic to normal human cell lines, but strikingly toxic to glioblastoma cell lines. We were excited because those cancer cells are notoriously hard to kill," Polidore said.

Although pantaphos is somewhat toxic to human cell lines, it is possible that it will not be toxic to whole animals. "If you feed pantaphos to a mouse and it doesn't get taken up in the intestine, it will be much less toxic," Metcalf said. "Thus, our cell line studies are preliminary and will require follow-up experiments to define the level of toxicity in humans."

The researchers are currently trying to understand how pantaphos kills weeds and glioblastoma cells. The results of those studies may help them design modified versions of the molecule that affect only the desirable targets. Using bioinformatic analysis, they have also found similar hvr genes in other bacteria, indicating that there may be several pantaphos-like molecules that could be used as potential herbicides or therapeutic drugs.

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The study "A Phosphonate Natural Product Made by Pantoea ananatis is Necessary and Sufficient for the Hallmark Lesions of Onion Center Rot" can be found at 10.1128/mBio.03402-20. The study was funded by the National Institutes of Health.

Study finds increased risk of death among breast cancer patients who drink sugar-sweetened soda

Women who reported drinking non-diet soda five times or more per week were 85% more likely to die from breast cancer

UNIVERSITY AT BUFFALO

Research News

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IMAGE: STUDY FIRST AUTHOR NADIA KOYRATTY IS AN EPIDEMIOLOGY PHD CANDIDATE IN THE UNIVERSITY AT BUFFALO SCHOOL OF PUBLIC HEALTH AND HEALTH PROFESSIONS. view more 

CREDIT: UNIVERSITY AT BUFFALO

BUFFALO, N.Y. -- New research from the University at Buffalo suggests that breast cancer patients who drink sugar-sweetened beverages regularly are at increased risk for death from any cause and breast cancer in particular.

Compared to women who never or rarely drank non-diet soda, those who reported drinking non-diet soda five times or more per week had a 62% higher likelihood of dying from any causes, and were 85% more likely to die from breast cancer specifically. The findings were published online ahead of print March 2 in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

Research on soda and breast cancer is fairly new, says study first author Nadia Koyratty, a PhD candidate in the Department of Epidemiology and Environmental Health in UB's School of Public Health and Health Professions. Because breast cancer is so common, recommendations regarding lifestyle choices to breast cancer survivors are of considerable importance. And, despite the negative health outcomes associated with drinking soda, such as weight gain, Type 2 diabetes and cardiovascular disease, many people continue to drink sugar-sweetened sodas.

There have been only a few observational studies examining the association between sugar-sweetened beverages and cancer mortality. "This study is one of the few that looks at the prognosis of women with breast cancer with respect to non-diet soda consumption," Koyratty says.

Researchers assessed the relationship between sugar-sweetened soda and both all-cause and breast cancer mortality among 927 women who had been diagnosed with breast cancer, aged 35 to 79. Participants were enrolled in the Western New York Exposures and Breast Cancer (WEB) Study, and followed for a median of nearly 19 years.

The study used a food frequency questionnaire to assess participants' food and beverage intake in the 12 to 24 months prior to diagnosis of breast cancer. Of the more than 900 women diagnosed with breast cancer, 41% had died by the end of the follow-up period. Among the participants who had died, there was a higher percentage of women who reported high frequency of sugar-sweetened soda consumption compared to the women who were still living.

The associations did not change when researchers included diet soda consumption as a variable.

Why the focus on non-diet soda?

"Non-diet sodas are the highest contributors of sugar and extra calories to the diet, but they do not bring anything else that is nutritionally beneficial," Koyratty explains. "On the other hand, teas, coffees and 100% fruit juices, unless sugars are added, are healthier beverage options because they do add to the nutritive value through antioxidants and vitamins."

Sugar-sweetened sodas contain large quantities of sucrose and fructose, which give them the highest glycemic load compared to other foods or beverages. These higher concentrations of glucose and insulin may lead to conditions that have been associated with higher risk of breast cancer, the researchers note.

"There are more than 3.5 million breast cancer survivors alive in the U.S. today. We need to better understand the factors that affect their health," said study senior author Jo L. Freudenheim, PhD, SUNY Distinguished Professor in the Department of Epidemiology and Environmental Health in UB's School of Public Health and Health Professions.

"While we need more studies to confirm our findings, this study provides evidence that diet may impact longevity of women after breast cancer," Freudenheim added.

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Study co-authors include Susan McCann, PhD, of Roswell Park Comprehensive Cancer Center; Amy Millen, PhD, associate professor of epidemiology and environmental health at UB; and Maurizio Trevisan, MD, of Vin University.

The research was supported in part by grants from the Army Medical Research and Material Command, National Cancer Institute and the National Institute on Alcohol Abuse and Alcoholism.