Tuesday, September 07, 2021

 

Injuries to Children and Adolescents by Law EnforcementAn Analysis of California Emergency Department Visits and Hospitalizations, 2005-2017

JAMA Pediatr. Published online September 7, 2021. doi:10.1001/jamapediatrics.2021.2939

Police violence is a critical issue associated with adverse health throughout the lifecourse.1 Exposure to police violence in youth may be uniquely harmful, as adverse experiences during sensitive developmental stages have health implications that compound into adulthood.2,3 Long-standing work by activists and organizers to address police violence has led to calls for documentation of health outcomes among youth that are associated with policing practices.1-3

To date, the few health studies on police violence among youth have elucidated mechanisms of exposure to policing practices, including direct contact (eg, stop and frisk), anticipatory contact (eg, surveillance), vicarious contact (eg, witnessing police violence), and in utero exposure.2,3 They have also found associations between policing practices and adverse health outcomes, including anxiety and posttraumatic stress disorders, injury, and death, demonstrating the health harms associated with policing even when it is operating as designed.3,4 Further, police violence against youth is patterned by experiences of structural marginalization, with racially minoritized youth disproportionately targeted and harmed by policing practices.2-4 However, this literature groups together youth of all ages or reports findings for boys alone, potentially obscuring important patterns. We examined demographic and temporal distributions of hospital-treated injuries perpetrated by law enforcement among youth at the intersection of age, sex, and race and ethnicity.

Methods

We used statewide emergency department and hospitalization data from California between January 2005 and December 2017. The California Health and Human Services Agency and University of California, Berkeley Committees for the Protection of Human Subjects approved this study. Informed consent was not required because in California, confidential deidentified patient-level hospital data sets are available for research purposes through the Information Practices Act. Injuries caused by law enforcement among patients aged 0 to 19 years were identified using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) and ICD-10-CM codes for legal intervention injury (eMethods in the Supplement). We calculated legal intervention injury rates per 100 000 person-years overall and by age, sex, and race and ethnicity (identified in the patient record), and at their intersections. We estimated rate ratios and rate differences with 95% CIs to examine inequities by demographic characteristics. Data set cleaning and creation were performed using SAS version 9.4 (SAS Institute) and analyses were conducted in R version 3.6.1 (the R Foundation). We conducted a sensitivity analysis to assess whether results were robust to changes in injury codes across the ICD transition (eMethods in the Supplement).

Results

There were 15 967 youth treated for legal intervention injury in California hospitals from January 2005 to December 2017 (Table). The overall rate of injury was 11.9 per 100 000 person-years. Black youth experienced higher injury rates than youth of other races and ethnicities. Black boys aged 15 to 19 years had the highest rate (200.9 per 100 000 person-years), experiencing 143.2 additional injuries per 100 000 person-years (95% CI, 134.8-151.6) compared with White boys of the same age (rate ratio, 3.5; 95% CI, 3.3-3.7). Compared with White girls aged 15 to 19 years, Black girls of the same age experienced 4.3 times the injury rate (95% CI, 3.7-4.9). Relative inequities between Black and White youth were even greater among those aged 10 to 14 years. Black boys had 5.3 times (95% CI, 4.3-6.5) the injury rate of White boys, and Black girls experienced 6.7 times (95% CI, 4.8-9.5) the injury rate of White girls. The rate among Black girls was higher than all other groups except Black boys.

Legal intervention injury rates increased and then declined between 2005 and 2017, with Black boys experiencing a much sharper increase and later decline (Figure). The trajectory for Black girls was closer to that for White boys and Latinx or Hispanic boys than that of girls of any other race or ethnicity, and their rate of injury was higher than that of White and Latinx or Hispanic boys by 2017.

Discussion

While youth are generally less likely than adults to be injured by policing practices, our findings note the protections of childhood are not afforded to all children.5 Black youth in California experience a substantially greater burden of injuries perpetrated by law enforcement than youth of other races and ethnicities. This is consistent with evidence that police violence is a pathway through which structural racism operates in young people’s lives, primarily impacting racially minoritized youth and contributing to health inequities.2-4 Our intersectional analyses document the unique impact on Black girls, reflecting literature on how Black girls are more likely than White girls to be adultified—that is, perceived as older than they are, less innocent, and in need of less protection—with serious repercussions for more aggressive legal system targeting.6

This study has limitations. Research has found that death certificate data underreport when Black individuals in the US are killed by law enforcement.4 If similar patterns are present in hospital administrative data, the racial inequities documented in this study may be underestimated. Although sensitivity analyses confirmed result robustness across the ICD transition (eMethods in the Supplement), it is possible that ICD coding changes influenced post-transition rates. While California has a large, diverse population, future work should document legal intervention injury among youth in other contexts.

Joining in the precedent set by organizing movements, leading health organizations have recently issued guidance on systems-level interventions to address police violence and its implications for youth.1,3 Concurrently, a new pediatric framework recommends well-child questions about police interactions.3 Clinicians can serve an important role in documenting these incidents, providing compassionate care and connection to services, and advocating for structural intervention.

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Article Information

Accepted for Publication: May 26, 2021.

Published Online: September 7, 2021. doi:10.1001/jamapediatrics.2021.2939

Corresponding Author: Kriszta Farkas, PhD, MPH, Division of Epidemiology, School of Public Health, University of California, Berkeley, 2121 Berkeley West Way, Room 5302, Berkeley, CA 94720 (kfarkas@berkeley.edu).

Author Contributions: Drs Farkas and Ahern had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: All authors.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: Farkas, Duarte.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Farkas.

Obtained funding: Duarte, Ahern.

Supervision: Ahern.

Conflict of Interest Disclosures: Dr Farkas reports grants from the National Institutes of Health and the University of California Firearm Violence Research Center during the conduct of the study. Dr Duarte reports grants from the Robert Wood Johnson Foundation Health Policy Research Scholars program during the conduct of the study. Dr Ahern reports grants from the National Institutes of Health during the conduct of the study and outside the submitted work.

Funding/Support: This work was supported by grant DP2HD080350 from the National Institute of Child Health and Human Development Office of the Director and funding from the University of California Firearm Violence Research Center. Dr Duarte is also supported by a Health Policy Research Scholars program grant from the Robert Wood Johnson Foundation.

Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Disclaimer: The analyses, interpretations, and conclusions presented are attributable to the authors and not to the California Department of Public Health.

References
1.
American Public Health Association. Addressing law enforcement violence as a public health issue. Accessed January 3, 2021. https://www.apha.org/policies-and-advocacy/public-health-policy-statements/policy-database/2019/01/29/law-enforcement-violence
2.
Duarte  CDP, Salas-Hernández  L, Griffin  JS.  Policy determinants of inequitable exposure to the criminal legal system and their health consequences among young people.   Am J Public Health. 2020;110(S1):S43-S49. doi:10.2105/AJPH.2019.305440PubMedGoogle ScholarCrossref
3.
Boyd  RW, Ellison  AM, Horn  IB.  Police, equity, and child health.   Pediatrics. 2016;137(3):e20152711. doi:10.1542/peds.2015-2711PubMedGoogle Scholar
4.
Feldman  JM, Gruskin  S, Coull  BA, Krieger  N.  Quantifying underreporting of law-enforcement-related deaths in United States vital statistics and news-media-based data sources: a capture–recapture analysis.   PLoS Med. 2017;14(10):1-20. doi:10.1371/journal.pmed.1002399Google Scholar
5.
Goff  PA, Jackson  MC, Di Leone  BAL, Culotta  CM, DiTomasso  NA.  The essence of innocence: consequences of dehumanizing Black children.   J Pers Soc Psychol. 2014;106(4):526-545. doi:10.1037/a0035663PubMedGoogle ScholarCrossref
6.
Epstein  R, Blake  JJ, Gonzalez  T. Girlhood interrupted: the erasure of black girls’ childhood. Georgetown Law Center on Poverty and Inequality. Accessed February 23, 2021. https://www.law.georgetown.edu/poverty-inequality-center/wp-content/uploads/sites/14/2017/08/girlhood-interrupted.pdf

Police Exposures and the Health and Well-being of Black Youth in the USA Systematic Review

JAMA Pediatr. Published online September 7, 2021. doi:10.1001/jamapediatrics.2021.2929
Key Points

Question  Is exposure to police associated with adverse health outcomes for Black youth in the US?

Findings  In this systematic review of 29 studies that included 19 954 participants, police exposure was associated with multiple health outcomes for Black youth, including adverse mental health, risk behaviors, and impaired safety.

Meaning  Police exposure should be considered a critical determinant of health.

Abstract

Importance  Black youth in the US experience disproportionate contact with police even when accounting for criminal or delinquent behavior, which some experts say is fueled by racism and discrimination. While the literature supports the link between racism and adverse health outcomes, less is known about the impact of policing on the well-being of Black youth.

Objective  To systematically review the literature describing the association between police exposure and health outcomes for Black youth 26 years and younger.

Evidence Review  A search of PubMed, Embase, Criminal Justice Abstracts, PsycInfo, and Web of Science was conducted. Eligible studies included original peer-reviewed research published from 1980 to December 2020, with a participant population of Black youth, a focus on police exposure, and health as the outcome. Additional articles were identified by hand-searching reference lists of included studies. Data extraction was performed, followed by critical appraisal of all included studies using a convergent segregated approach in which quantitative and qualitative studies were synthesized separately followed by an overarching synthesis across methods.

Findings  A total of 16 quantitative studies including 19 493 participants were included in the review and demonstrated an association between police exposure and adverse mental health, sexual risk behaviors, and substance use. A total of 13 qualitative studies including 461 participants were included in the review, which corroborated and contextualized the quantitative evidence and provided additional health outcomes, such as fear for life or hopelessness.

Conclusions and Relevance  Evidence shows that police exposures are associated with adverse health outcomes for Black youth. Clinicians, scientists, public health practitioners, and policy makers can partner with local governments to enact reforms that mitigate the health impact of policing on youth.

Introduction

Black youth in the US experience contact with the police as early as 8 years old,1 and by age 24 years, they have nearly 9-fold the number of encounters with police as their White counterparts.2 Furthermore, Black youth are more likely to experience use of force3 and 5-fold as likely to experience injury during these interactions.4 Such racial disparities in police contact are poorly explained by individual-level differences in delinquency. In fact, among Black individuals, arrest odds strengthen after accounting for differential crime involvement.5-9 Research also shows that police tend to evaluate Black boys as being 4 years older than their actual age and as less innocent compared with White children.10 Such disproportionate contact and differential treatment has been identified as a form of structural racism.11,12 While the literature supports the link between racism and adverse health outcomes,13 less is known about the impact of policing on the well-being of Black children.

The American Academy of Pediatrics recently examined the impact of racism on child health and called for evidence-based strategies to dismantle structures that perpetuate racism.14 Additionally, the American Public Health Association highlighted police violence as a public health issue given its disproportionate impact on marginalized populations.15 Despite a national push to address racism and policing, researchers have yet to critically appraise the state of the science regarding policing, race, and child health. This mixed-methods systematic review fills a critical gap by examining the existing literature documenting the association between police exposures and health for Black youth, an important step in informing future changes to practice and policy. We hypothesize that police exposures will be associated with adverse health for Black youth.

Methods

This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline.16 We examined studies that explored the association between police exposures and health outcomes for Black youth 26 years and younger.

Literature Search Strategy

We searched the following databases on December 19, 2020: PubMed, Embase, Criminal Justice Abstracts, PsycInfo, and Web of Science (eFigure 1 in the Supplement). Search terms were developed by one of us (M.J.) with the assistance of a medical librarian and encompassed the following concepts: (1) police, (2) Black, and (3) health outcomes (eFigure 1 in the Supplement).

Study Selection and Data Extraction

Following removal of duplicates, 2 independent reviewers (M.J. and A.M.) performed title, abstract, and full-text screening as well as data extraction using Covidence software (Veritas Health Innovation). Included studies were peer-reviewed original research (quantitative or qualitative) conducted in the US and published between 1980, when community policing became prevalent, and December 2020. The study population was Black youth. Studies were included if participants 26 years and younger and 50% or more of the study population included Black participants or if there was a subgroup analysis of Black participants (ie, race stratification, with race as a modifier variable). For studies with less than 50% Black participants and race as a covariate, authors were contacted to request subgroup analyses. If subgroup analyses were not available, the study was excluded. Additionally, Hispanic/Latinx ethnic subgroups were excluded if Black race was not indicated.

Exposure of Interest

The main exposure of interest was exposure to police, which was operationalized to include police contact (presence of police in schools, personal experiences ranging from benign stops to use of force and arrest, and vicarious exposure) and perceptions of police discrimination. Presence of police in schools was included given research indicating that more than 1 million children in the US attend schools with police.17 Vicarious exposures and perceptions of police were included given evidence supporting their impact on child health.18

Outcome of Interest

Health outcomes included physical health, mental health, risk behaviors (eg, substance use), and safety. Three studies assessed physical health outcomes and were excluded given no comparable studies.19-21 Mediation analyses were included if direct associations between police exposure and health outcomes were reported. We identified additional articles by hand-searching reference lists of included studies. Disagreements were resolved through discussion with coauthors (K.B.M., M.T., and R.L.J.T.).

Quantitative and Qualitative Quality Assessment

To assess study quality for quantitative studies, we used the Quality Assessment Tool from the Effective Public Health Practice Project, which assesses studies based on selection bias, study design, confounders, data collection, and analysis.22 For qualitative studies, we used the National Institute for Health and Care Excellence methodology checklist,23 which assesses studies based on theoretical approach, study design, data collection, validity, analysis, and ethics. Each study was assigned an overall rating of strong if they had no weak ratings, moderate if they had 1 weak rating, and weak if they had 2 or more weak ratings.

Statistical Analysis

We used a convergent segregated approach, which involves synthesizing all studies separately according to their design (quantitative vs qualitative), followed by an overarching synthesis across methodologies (Figure 1).24 We grouped health outcomes from quantitative studies into categories and characterized the direction of their associations (positive, negative, or null) with police exposures. A P value less than .05 was considered statistically significant, and null associations indicated no statistical significance. A meta-analysis was not performed owing to study heterogeneity. For the qualitative studies, we performed thematic synthesis.25 Using MAXQDA software version 18.2.5 (VERBI Software), we conducted open-ended coding on each text-unit (ie, sentences or paragraphs) within the Results and Discussion sections. Similar concepts were grouped into descriptive themes, which were grouped into analytic themes and organized by health domain. If the same data were used in more than 1 study,26-33 the additional studies derived from the same data were only included if they elicited new themes. A combined synthesis of the results was performed by juxtaposing quantitative and qualitative findings within a matrix to compare findings.

Results
Study Characteristics

We screened 2997 titles and abstracts and 259 full-text manuscripts. A total of 23 manuscripts met inclusion criteria, and 6 studies were added from reference lists. Characteristics of included studies are summarized in Table 1. Detailed summaries of all included studies can be found in the eTable in the Supplement, and the PRISMA flow diagram can be found in eFigure 2 in the Supplement.

The 29 studies in this review (16 quantitative and 13 qualitative) include data from 19 954 participants aged 9 to 26 years old. A total of 27 studies (93%) included adolescents or young adults (aged 12 to 26 years). A total of 16 studies (55%) included male and female participants. A total of 11 studies (38%) assessed male participants only, 3 of which (27%) focused on men who have sex with men. A total of 2 studies (7%) focused on transgender adolescent girls and young women only. A total of 22 studies (76%) involved a sample composed of 50% or more Black persons. The remaining 7 studies (24%) included subgroup analyses by race.

Police Exposures

Quantitative and qualitative studies operationalized police exposure broadly. A total of 13 of 16 quantitative studies (81%) assessed police contacts, while 3 of 16 (19%) assessed perceptions of police discrimination. All used self-reported measures. Qualitative studies addressed a variety of police exposures, including police contact and perceptions of police discrimination, many of which addressed multiple types of police exposures within one study.

Health Outcomes

Quantitative and qualitative studies operationalized health outcomes broadly to include mental health, risk behaviors, and safety.

Quality Assessment

Figure 2 summarizes the quality ratings by category as well as global ratings for all studies.34,35 Most included studies (21 of 29 [72%]) were of moderate or strong quality. Among the quantitative studies, 3 (20%) were rated strong, 7 (40%) were rated moderate, and 6 (40%) were rated weak. Among the qualitative studies, 5 (39%) were rated strong, 6 (46%) were rated moderate, and 2 (15%) were rated weak.

Synthesis
Quantitative Synthesis

Table 2 summarizes the associations between police exposures and health outcomes for the included quantitative studies.36-51 Most quantitative studies (13 [81%]) indicated a positive association between police exposures and adverse health for Black youth.

Adverse Mental Health

Nine studies (56%) examined 20 distinct associations between police exposures and adverse mental health.36,37,41,42,44,46,48,50 Police exposure was associated with poor public regard (β = −0.305; SE = 0.135; P = .02),41 sadness (odds ratio [OR], 1.47; 95% CI, 1.18-1.82; P < .001),44 anger (β = 0.12; 95% CI, 0.03-0.21; P < .0148; OR, 1.40; 95% CI, 1.14-1.72; P < .00144), externalizing behaviors (β = 0.081; SE = 0.048; P < .05),50 fear (OR, 1.56; 95% CI, 1.20-2.02; P < .001),44 psychological distress (β = 0.05; SE = 0.02; P < .01),37 and feelings of safety (OR, 1.21; 95% CI, 1.01-1.44; P = .04).46 Police exposure was associated with stress in 4 of 5 associations (β = 0.723; SE = 0.340; P < .05; β = 0.862; SE = 0.421; P < .05; β = 1.003; SE = 0.427; P < .05; β = 1.614; SE = 0.417; P < .001),42 with one revealing no association.41 There were mixed findings for the association between police exposure and depression, with 4 positive associations (β = 0.161; SE = 0.044; P < .01; β = 0.146; SE = 0.041; P < .01; β = 0.034; SE = 0.009; P < .0149; β = 1.12; SE = 0.43; P < .0136) and 3 showing no association.36,41,48 Most studies (6 [67%]) were of moderate or strong quality.

Risk Behaviors

Four studies (27%) examined 6 distinct associations between police exposures and sexual risk behaviors.38,39,45,47 Positive associations were seen with intentions to have sex (OR, 1.52; P < .05),38 number of anal sex partners (event rate ratio, 1.89; 95% CI, 1.41-2.55; P < .001),47 and number of overall sex partners (event rate ratio, 1.43; 95% CI, 1.13-1.81; P < .01).47 No association was seen with unprotected anal intercourse.39,45,47 There were no negative associations. Overall, the studies were of moderate or strong quality, with the exception of a single study examining police exposure and sexual intentions, which was of weak quality.38

Three studies (20%) examined 8 associations between police exposures and substance use.40,43,51 Positive associations were seen with smoking for boys (OR, 2.0; 95% CI, 1.2-3.4) but not for girls.51 There were mixed findings for the association between police exposure and drug use, with 5 positive associations (men: β = 0.268; P < .001; women: β = 0.357; P < .00140; β = 0.40; SE = 0.16; P < .05; β = 0.64; SE = 0.17; P < .001; β = 0.47; SE = 0.18; P < .01),43 and 1 showing no association (β = 0.15; SE = 0.17).43 Most studies of risk behaviors were of moderate or strong quality (4 [57%]).51

Qualitative Synthesis

Table 3 summarizes the themes identified for the included qualitative studies.26,29,31,32,52-55 Qualitative synthesis resulted in the identification of descriptive themes,25 which were grouped into analytic themes and were ultimately organized within 3 health domains, including mental health, risk behaviors, and safety.

Mental Health

The mental health domain includes the following analytic themes: psychological distress, maladaptive coping, vicarious impact, and role confusion.

Psychological Distress

Eleven studies (85%) explored police exposures and psychological distress, which comprises the descriptive themes of internalizing symptoms26,29,31,32,52-58 (ie, feelings of depression, anxiety, withdrawal, hypervigilance) and externalizing symptoms29,31,32,52,57-59 (ie, feelings of anger, aggression, resentment).

Maladaptive Coping

Twelve studies (92%) explored police exposures and maladaptive coping, which includes the descriptive themes of identity negotiation32,53,54,56,60 (ie, fear influences self-acceptance), self-policing one’s behavior29,31,32,55,56,60 (ie, adjusting behavior to avoid feeding into stereotypes), normalizing29,31,55,57,59 (ie, perceiving negative police interactions as normal, minimizing resultant symptoms), and resignation to injustice26,29,32,52,56-58 (ie, negative police interactions are inevitable).

Vicarious Impact

Seven studies (54%) explored police exposures and vicarious impact, which includes the descriptive themes of personal impact of publicized killings26,31,32,52,56-58,60 (ie, impact even if not the victim or connected to victim), messaging to loved ones26,52,56 (ie, negative police encounters influence messaging to family), imposing fear on family members52 (ie, guilt related to family’s fear for their lives), and fear for family members31,56,57 (ie, fear for family and resultant negative toll).

Role Confusion

Six studies (46%) explored police exposures and role confusion, which includes the descriptive themes of cannot be a kid29,32,52,56,58 (ie, policed while waiting for the bus, studying, playing sports) and cannot be a concerned family member31 (ie, danger in defending loved ones to police).

Risk Behaviors

The risk behaviors domain includes the following analytic themes: risk taking, impairment of future orientation, and inability to engage in prosocial activities.

Risk Taking

Two studies (15%) explored police exposures and risk taking,54,55 which includes the descriptive themes of sexual risk behaviors54 (ie, sexual behaviors predisposing youth to adverse health outcomes) and substance use (ie, use of substances, including alcohol and drugs).55

Impairment of Future Orientation

Twelve studies (92%) explored police exposures and future orientation, which includes the descriptive themes of fear for life26,32,52-61 (ie, fear of being killed by police regardless of actions) and hopelessness29,32,55,60 (ie, hopeless regarding police interactions).

Inability to Engage in Prosocial Activities

Eight studies (62%) explored police exposures and inability to engage in prosocial activities, which includes the descriptive themes of social spaces for destressing off limits29,31,32,52,58,61 (ie, inability to be with friends in public spaces, such as parks), group gatherings deemed suspicious31,32,61 (ie, policed when in groups with an assumption of gang or criminal activity), overpolicing discouraging family visits26 (ie, family avoid visiting or will not pick up youth because of policing in neighborhood), and social isolation or exclusion32,53,54 (ie, hypersurveillance plus discrimination leads to feelings of loneliness and feeling unwanted).

Safety

The safety domain includes the following analytic themes: maltreatment and vulnerability to violence.

Maltreatment

Ten studies (77%) explored police exposures and experiences of abuse, which includes the descriptive themes of verbal abuse29,31,53,56,58,59 (ie, use of racial epithets, name calling, and aggressive language), physical abuse29,31,53,55,56,58,59 (ie, kicked, choked, punched, gun placed in mouth), sexual abuse31,53 (ie, sexual assault), and dehumanization29,31,32,52,53,55,58,60 (ie, humiliation; labeled as stupid, worthless).

Vulnerability to Violence (Police and Community)

Five studies (39%) explored police exposures and vulnerability to police and community violence, which includes the descriptive themes of interactions impact compliance26 (ie, previous interactions instill fear and lead to flight response), treatment impacts compliance26 (ie, being antagonized leads to defiance), concerns ignored29,31,53,58,59 (ie, not being believed by police or concerns not taken seriously), victim blaming53,59 (ie, blamed when reporting concerns), avoiding help from police26 (ie, avoidance of seeking help because of previous experience or desire to not be associated with police within neighborhood), and purposeful abandonment by police29,31 (ie, instances in which police knowingly abandon youth in unsafe neighborhoods far from home).

Overall, the included qualitative studies were of moderate to strong quality, with the exception of 2 studies (15%) of weak quality.52,57

Synthesis of Quantitative and Qualitative Studies

Juxtaposition of the health outcomes measured in quantitative studies with the themes explored in the qualitative studies resulted in a combined analysis.

Supportive and Contradictory Findings

There were corroborating and contradictory findings across the health domains. Within mental health, qualitative studies consistently identified themes about police exposure and internalizing symptoms, such as stress and depression. However, quantitative findings were mixed with a largely positive association with stress but mixed findings regarding depression. Contradictory findings were also seen for feelings of safety vs fear. One quantitative study showed police exposure was associated with feelings of safety, which was not supported by the 1 quantitative study44 assessing fear nor by the multiple qualitative studies26,32,52-61 showing police exposure’s association with fear for life. Quantitative and qualitative studies, however, both showed associations and identified consistent themes between police exposures and anger/aggression (referred to as externalizing symptoms) and vicarious impact.

Within the domain of risk behaviors, while both quantitative and qualitative evidence showed associations and identified consistent themes with sexual risk behaviors, findings were contradictory for unprotected anal sex. Quantitative studies showed positive associations but were not statistically significant, while qualitative evidence indicated transgender adolescent girls and young women reported avoiding carrying condoms because of fear of police. Lastly, both syntheses showed associations and identified themes with substance use. Quantitative literature studied drug use and smoking, while qualitative literature additionally explored alcohol use.

Qualitative Evidence That Explains Quantitative Evidence

Qualitative evidence helps explain the quantitative associations between police exposures and mental health. Participants reported anger as a result of having to respond to racism and interact with a system in place to protect that instead caused them harm. Repeated negative exposure and the inability to resolve confrontation with police were also cited as leading to symptoms of depression. Marginalization and being assumed to be guilty contributed to frustration, anxiety, and hopelessness.

Qualitative evidence also helps explain the quantitative associations with risk behaviors. Youth reported avoiding carrying condoms owing to fear of police confiscation and subsequent assertion that condoms are evidence of sex work. Participants also noted that lack of support from social institutions, including police, diminished self-worth, and made them more vulnerable to risky sexual behaviors and substance use.

Qualitative Evidence That Explains Differences Across Studies

While the qualitative studies identified themes connecting police exposures and mental health, quantitative studies that examined depression had mixed findings. The conflicting direction of these results may be explained by the qualitative evidence, showing that Black boys and young men may not label their depressed mood as a mental health issue secondary to normalizing or avoiding stigma. Furthermore, qualitative evidence indicated themes connected with intermediary symptoms, such as worry, stress, and nervousness, which may be precursors to the outcomes measured in many of the quantitative studies, such as depression and anxiety.

Outcomes and Phenomena Explored in Only One Methodology

There were analytic themes from the qualitative literature that were not examined in any of the quantitative studies. Within the mental health domain, this included maladaptive coping and role confusion. Within the risk behaviors domain, this included inability to engage in prosocial activities. Lastly, within the safety domain, this included maltreatment and vulnerability to violence.

Discussion

Our review found that the current body of evidence, although limited, reveals a positive association between police exposure and adverse health outcomes for Black youth. To our knowledge, this is the first study that comprehensively synthesizes this research and furthermore uses qualitative evidence to contextualize quantitative findings. Of the 29 studies, 25 reported at least 1 association or thematic link between police exposure and adverse health outcomes. Of the 8 studies of strong quality (3 quantitative and 5 qualitative), all found associations or themes regarding policing and adverse health outcomes. The 3 studies, all quantitative, that did not reveal this association were of weak or moderate quality. While there has been a growing focus on the most serious consequences of police exposure, including death, this systematic review brings to light that seemingly trivial police contact or even the fear of contact may be detrimental to the health of Black youth.

Although the quantitative associations and qualitative themes linking police exposure to adverse health outcomes were highlighted across both methodologies, qualitative studies illuminated the specific role of racism within this association. Similarly, the wide-range of settings—grade schools, historically White colleges, neighborhoods of varying racial compositions, streets, and parks—emphasizes the ubiquity of such encounters as well as the role of racial bias in policing Black youth. Prior research linking racism to adverse mental health,62 substance use,63,64 and sexual risk behaviors65 supports the notion that racism is a key contributor to police exposure’s association with adverse health.62

Implications for Research

This review bares important methodological considerations for future research. First, there is no consensus on police exposure measurement. Future research may use standardized tools, such as the Police and Law Enforcement Scale,66 or draw from adult literature that uses various data sets67,68 to perform ecological analyses. For example, data from Mapping Police Violence69 was used to show that participants living in the same states as recent police killings had an increase in adverse mental health.68 With increasing national attention on police violence,70 ecological analyses will be an important consideration for forthcoming studies.

Second, while frequency of exposure and use of force have been shown to have dose-related effects on health, few studies interrogated this.36,42 To fully capture policing’s impact on health, we recommend including these details when measuring exposure.

Third, using nonracially diverse samples or race as a covariate creates difficulty in drawing comparisons between groups. The racial gradient theory purports that Black individuals are treated worse than Latinx individuals who are treated worse than White individuals.71 Future research may use diverse samples and race stratification or effect modification to probe racial disparities more accurately.

Additionally, this review shows that police exposures are associated with intermediary health outcomes, such as fear and hopelessness, which impede a child’s ability to thrive72 and may later manifest as depression or anxiety. By studying health outcomes along the continuum, we will gain a more comprehensive understanding of police exposure’s true impact. Also, although adult literature has explored physical health, including physiological impacts of policing on cortisol levels and telomere length,73 physical health was not studied in any of the included quantitative studies, a gap in pediatric literature.

Lastly, there is a dearth of literature examining police exposure in additional sectors, such as within schools. While one study included in this review reveals police presence was associated with feeling safe, this same study shows that Black students were more likely than students of other races to be disciplined despite their positive perceptions of police.46 Similarly, policing in schools is associated with poor test scores and dropout.74 As the presence of police officers increases in schools,75 educational settings are an important setting to conduct future research.

Implications for Practice and Policy

Our research suggests that it is vitally important to consider the influence that policing has on Black youth across multiple sectors. Pediatric clinicians must use a standardized approach to screen youth for not only exposure to police but also the quality of such exposure (eg, use of force, racially tinged language, other forms of harassment). They then can use tools to screen for associated health manifestations and referral to ancillary services (eg, mental health resources) to ensure high quality of care when children experience negative police encounters. Pediatric clinicians can also partner with public health practitioners and policy makers to support community and legislative reforms that focus on mitigating the health impact of police exposures on youth, which may include youth-specific limits to touch and force, youth development training for police, or alternative approaches to safety that limit the use of police in spaces that youth frequent.

Limitations

The results from this review must be considered in light of its limitations. No studies included youth younger than 9 years, suggesting the difficulty in extrapolating this evidence to children of all ages. However, research showing police exposure’s association with low birth weight corroborates that children are impacted by policing even while in the womb.19 Future work may consider innovative approaches, such as use of drawings to interrogate police’s impact on younger children.76

Additionally, most studies used cross-sectional analyses that cannot assess temporality and may have confounders. However, the included longitudinal analyses did reveal robust associations with police exposure and adverse health outcomes.

Lastly, only 6 of 15 quantitative studies adjusted for delinquent behavior. While previous literature debunks the perception that Black youth’s contact with police is linked to differential wrongdoing, some continue to overestimate criminal involvement for Black youths. Further prospective analyses that adjust for delinquent activity will serve to bolster current evidence that decouples racial disparities in police contact and criminal activity. It is also important to note that youth’s experiences of discrimination and abuse within police encounters renders the presence of criminal activity potentially immaterial to the association between police exposure and adverse health.

Conclusions

This systematic review is an important step in understanding the association between police exposures and adverse health outcomes for Black youth. Despite limitations, it fills a critical gap in the literature and highlights the need for additional, rigorous prospective research assessing the association between police exposure and health among Black youth, who are disproportionately exposed to police interactions. Building the cumulative evidence base is vital to inform the efforts of pediatric clinicians as we partner with other scientists, public health practitioners, and policy makers to continue to shine a bright light on the long-standing health inequities that result from unequal and unfair treatment.


 

Babies wanted: Males need not apply


Japanese scientists make sperm from mouse pluripotent stem cells that lead to healthy, fertile offspring

Peer-Reviewed Publication

KYOTO UNIVERSITY

Frozen sections of 52-day-old samples cultured by the in vitro sperm induction method were immunostained to confirm the formation of sperm. 

IMAGE: IMMUNOFLUORESCENCE ANALYSIS. FROZEN SECTIONS OF 52-DAY-OLD SAMPLES CULTURED BY THE IN VITRO SPERM INDUCTION METHOD WERE IMMUNOSTAINED TO CONFIRM THE FORMATION OF SPERM. RED INDICATES GSCLC MARKERS, GREEN INDICATES SPERM MARKERS, AND WHITE INDICATES NUCLEI view more 

CREDIT: PROVIDED BY TAKUYA SATO, AN ASSISTANT PROFESSOR AT YOKOHAMA CITY UNIVERSITY

For species that rely on sexual reproduction, including mice and men, offspring can only happen if sperm from the male fertilize eggs from the female. Even artificial fertilization techniques depend on donors for both of these cells. However, a new study led by ASHBi researchers shows that mouse pluripotent stem cells can differentiate into functional sperm. These sperm were successfully used to produce healthy, fertile offspring and provide the most comprehensive model yet for generating male germ cells in a test tube.

Pluripotent stem cells have allowed scientists to study how each and every cell in the body is formed. Brain cells, heart cells, and livers cells are just some examples of the cell types made from these stem cells and now being used in patients as experimental cell therapies. However, some cell types remain difficult to make from pluripotent stem cells, particularly sperm cells.

Among all cell types, germ cells are unique for many reasons. First, unlike all other cells, which carry 46 chromosomes, germs cells only have 23 chromosomes, with the egg having all its chromosomes from the mother, and sperm having all its chromosomes from the father.

Furthermore, they are the only cells that parents actually pass to their offspring, which makes them, according to ASHBi Director Mitinori Saitou, one of the authors of the study, “the driving force that sustains and evolves a species.”

Although more research is needed, scientists have made significant strides in producing sperm cells from pluripotent stem cells, at least for mouse. The process is generally broken into three stages that mimic natural development. First, the stem cells are differentiated into primordial germ cells, then into spermatogonia stem cells, which is when the male sex is determined, and finally sperm.

Spermatogonia stem cells are what allow the male to produce sperm for a lifetime, but this second stage has proven to be the most difficult to recreate in the laboratory.

Difficult, but not impossible. Mouse spermatogonia stem cells can be made, but inefficiently, which is why Dr. Yukiko Ishikura, another contributor to the study, concluded that optimizing the differentiation process was needed.

“The differentiation rate is about one week slower than in the mouse body and the contribution of the spermatogonia stem cells to spermatogenesis is low,” she said.

Beginning with mouse pluripotent stem cells, she and colleagues prepared primordial germ cells and examined over 10000 of them in 8 different conditions using what they call a “new reconstituted testis method”.

To validate the best conditions for manufacturing spermatogonia stem cells, they confirmed that the cells shared several properties with those in mouse testis, including the expression of key genes, epigenetics, and the transient upregulation of retrotransposons, which Saitou was especially unexpected.

“Retrotransposon control was recaptured. Retrotransposon regulation is a mechanism to control the effects of retrotransposons on key genes by randomly repeating their regulation,” he said.

The identical epigenetics was also crucial. While genes are made of DNA, their expressions depend on epigenetic factors like DNA methylation. Germ cells show distinct DNA methylation patterns during their development, patterns that are considered crucial for their ability to produce offspring.

To confirm the spermatogonia stem cells behaved just as those produced in the body, the researchers injected their laboratory made spermatogonia stem cells into mouse testes, where the cells were allowed to develop into spermatids. These spermatids were harvested and injected into eggs to grow embryos. The embryos were then used to impregnate mice, which went on to give birth to healthy offspring that were also fertile.

The findings provide the most comprehensive reconstitution of male germ cell development yet starting from pluripotent stem cells.

“This is the first study to reconstitute functional sperm from mouse pluripotent stem cells in a test tube. This open new possibilities for male germ cell differentiation,” said Saitou.

CAPTION

We show that we have succeeded in reproducing the entire differentiation process of male germ cells from mouse pluripotent stem cells in vitro.Top: scheme for male germ-cell development in mice. Bottom: scheme for the in vitro reconstitution of male germ-cell development by pluripotent stem cells. E, embryonic day; P, postnatal day.

CREDIT

Provided by Yukiko Ishikura, a postdoctoral researcher at ASHBi Kyoto University

 

ANTI SMOKING LOBBY

Legalization of cannabis threatens clean indoor air and public health


Most localities that allow onsite cannabis smoking lounges do not protect nonsmokers from the ill effects of secondhand cannabis smoke, researchers report in the American Journal of Preventive Medicine

Peer-Reviewed Publication

ELSEVIER

Ann Arbor, September 7, 2021  After years of progress on protections against secondhand tobacco smoke, multiple states and local governments now allow indoor smoking of cannabis at licensed cannabis businesses. A new study in the American Journal of Preventive Medicine, published by Elsevier, found that over 50 localities in the United States allow indoor smoking at these businesses, exposing customers and employees to secondhand cannabis smoke (SHCS).

“While many states maintain strong tobacco smoking and vaping bans to protect public health, our research reveals that some state and local laws exempt cannabis smoke from clean air laws and open the door to smoke-filled businesses, defeating decades of public health advances,” said first author Thomas L. Rotering, MPH, of the Center for Tobacco Control Research and Education, and the Philip R. Lee Institute for Health Policy Studies, University of California, San Francisco, San Francisco, CA, USA.

The researchers systematically searched legal databases, public reporting, government websites, and local laws that address cannabis smoking lounges. They found wide variation in how state and local governments address SHCS exposure in these businesses. All of the 11 states that have legalized adult-use cannabis as of June 2020 prohibit consumption in public places, but six states (Alaska, California, Colorado, Illinois, Massachusetts, and Michigan) allow onsite consumption in licensed cannabis businesses subject to local government approval. No state prohibits local governments from implementing more rigorous requirements. Massachusetts only allows onsite consumption through vaporization or other nonsmoking forms of consumption involving heat.

Although the only effective means of preventing the health problems associated with SHCS is to require a smoke-free environment, most local laws either do not address SHCS or use ineffective ventilation or engineering requirements. Of the 56 localities that permit onsite cannabis consumption businesses, only 9% require that indoors be smoke-free. Twenty-three percent of local governments provide for smoking in isolated rooms but only require that the smoke not drift to nonsmoking areas or that there be a smoke-free employee viewing area. Other common local legal requirements address onsite odor control, ventilation/filtration, and building location. Such requirements are often vague, and the investigators observe that they resemble the tobacco industry’s “accommodation” framework by allowing smoking inside and positioning ventilation or engineering controls as solving secondhand smoke.

“After decades of progress in clearing the indoor air of tobacco smoke, we are seeing it replaced with cannabis smoke using the same discredited arguments the tobacco industry used in its unsuccessful fight against tobacco smoke restrictions. We need to learn from the past and keep the air clean for all,” commented senior investigator Stanton A. Glantz, PhD, retired from the Center for Tobacco Control Research and Education, and the Philip R. Lee Institute for Health Policy Studies, University of California, San Francisco, San Francisco, CA, USA.

Some cannabis advocates argue that designating indoor spaces for renters, tourists, and people experiencing homelessness to smoke or vape is the only reasonable alternative to illegally consuming in public or exposing nonsmokers to SHCS. The investigators suggest that reasonable alternatives may include permitting outside, out-of-view cannabis use at retailers, or allowing only the use of non-inhalable modes of administration that do not pollute the air. Local officials could consider allowing multiunit housing or other places serving these groups to create outdoor, designated consumption smoking areas out of public view.

Policymakers should be made aware that ventilation and other engineering interventions cannot fully protect workers and patrons. “Health authorities and local leaders should educate policymakers on the science of secondhand smoke remediation and advocate for the same standards for secondhand cannabis smoking and vaping that apply to tobacco, particularly because other cannabis administration modes do not pollute the air,” said the authors in their paper. “Where onsite smoking or vaping is permitted, even measures such as truly separate indoor and outdoor smoking areas may reduce but not eliminate SHCS exposure to patrons, staff, and residents.”

 ABOLISH THE WAGE SYSTEM

Eliminating cash could benefit average U.S. families

New study shows tax cuts could offset giving up physical currency

Peer-Reviewed Publication

UNIVERSITY OF GEORGIA

Soon, $50 and $100 bills may be a thing of the past. That’s the future some economists are predicting—and want. 

But will people be better off without paper money? New research from the University of Georgia suggests they could be—as long as certain taxes are lowered too. 

“Our analysis of the costs and benefits of proposals to eliminate currency implies that doing away with big bills like $50s and $100s could benefit the average person, even though they like using cash,” said William D. Lastrapes, co-author on the study and the Bernard B. and Eugenia A. Ramsey Chair of Private Enterprise in the Terry College of Business. “Less cash means less tax evasion, so the government can reduce other taxes.”  

The case for getting rid of cash

Physical currency has an anonymity to it. The government doesn’t know you have it if you don’t report it and loses out on tax revenue from those “hidden” dollars. Cash transactions are also largely untraceable. Because of that, people paying for illegal goods or services and those who are simply trying to avoid paying taxes are more likely to do so in cash—and often in $50 and $100 bills. 

Published in the European Economic Review, the study uses macroeconomic modeling to predict how eliminating physical currency would affect individuals’ overall well-being from producing and consuming goods and services. 

The model builds in subtle tradeoffs that the economy faces when cash is used for transactions. When people use cash to hide their income from the IRS and reduce their taxes, for example, the government loses revenue to pay for valuable services or to pay down government debt. But at the same time, tax avoidance in effect lowers tax rates that consumers and businesses face, increasing productivity of labor and capital. That boosts the nation’s GDP and is good for the economy. 

When the model is matched to actual data on how people use cash and hide income from the IRS, it showed that people would be worse off if the Federal Reserve System, the U.S. central bank that issues cash, simply eliminated cash. The federal government would gain more revenue but overall production would fall because of the higher effective tax rates. And consumers would lose out on the privacy and convenience of cash.

But if the government also reduces statutory income tax rates—making the cash suppression policy revenue neutral—the model predicts that people overall will actually be better off without cash.

The model focused on the average American household. A more general version of the model shows that lower-income households, who are more likely to use cash for day-to-day transactions, will likely be more negatively affected by eliminating cash. But there are ways for the government to compensate for that.

“You’re going to have to provide them with some offset,” Lastrapes said. “What we’re suggesting is to take cash away but reduce taxes. It turns out this more than just compensates for not having cash, but it can actually make people better off.”

“My co-authors and I will be the first to admit that our paper does not provide the final word on cash-suppression policies and that more research is needed to be confident in what should be done. But our view is that models like ours that account for many of the unintended consequences of such policies and that carefully measure overall costs and benefits are essential for determining the right path.”

Transatlantic slave trade introduced novel pathogenic viruses in the Americas


Cutting-edge genetic techniques are shedding new light on how European colonists and their enslavement of African people may have contributed to epidemics among Indigenous communities in North America


Peer-Reviewed Publication

ELIFE

The transatlantic slave trade may have introduced new pathogenic viruses from Africa to North America that affected Indigenous communities, shows an analysis of ancient DNA published in eLife.  

The findings suggest that European colonists brought new viruses, including smallpox, measles and mumps, to North America, which caused outbreaks that led to major population declines in Native American communities. This discovery adds new information about the legacy of the transatlantic slave trade in North America.

“Multiple outbreaks in what is now Mexico killed millions of Indigenous people, Africans and some Europeans in the 16th century. But the exact pathogens responsible for some of these outbreaks is not currently known,” explains first author Axel Guzmán-Solís, a former student at the International Laboratory for Human Genome Research, Universidad Nacional Autónoma de México, Mexico, and who is now a PhD student at the Icahn School of Medicine at Mount Sinai, New York, US. “We wanted to understand what viruses were circulating in Mexico during this period.” 

To do this, Guzmán-Solís and the team extracted ancient viral DNA from the teeth of probable victims of these outbreaks buried at a Colonial-era hospital and chapel. They included victims who were Indigenous as well as those who were of African descent. The team then used this DNA to reconstruct the genomes of viruses present in those samples. This allowed them to identify ancient human hepatitis B virus and human B19 parvovirus from different individuals. By comparing these virus’ genomes to others, they found that the viruses likely originated in Africa.

“Our results suggest that the viruses were introduced to the Americas by colonists engaged in the slave trade,” says co-senior author Daniel Blanco-Melo, a former postdoctoral researcher at the Icahn School of Medicine at Mount Sinai in New York who is now an Assistant Professor at the Fred Hutchinson Cancer Research Center in Seattle, U.S. “The cruel, unsanitary and overcrowded conditions on the ships that transported millions of people across the Atlantic was a favourable setting for  the spread of infectious diseases. Therefore, this gruesome practice likely introduced new pathogens to Indigenous people who had no immunity to them.” He adds that the conditions that colonists forced Africans and Native Americans to live in during this time would have also promoted the spread of the diseases and may have fueled epidemics.

The study is not able to determine whether these individuals were infected in Africa, during the forced transport, or if the viruses occurred after the Africans’ arrival in North America. It is also unable to say whether the viruses caused the victims’ deaths. But it does provide evidence that these viruses, which can cause serious disease, were circulating in the affected populations.

“Our findings also suggest that multiple, newly introduced viruses were circulating at the same time, which may explain why the epidemics proved so deadly for Indigenous communities,” says co-senior author Maria Ávila-Arcos, Principal Investigator at the International Laboratory for Human Genome Research, Universidad Nacional Autónoma de México. “Together, this work demonstrates how the new field of paleovirology can help us learn more about the possible role of these and other pathogens in colonial epidemics and better understand the role of human actions in spreading them.”

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eLife

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