Ancient viral elements embedded in human genome not from fossil retrovirus

The ancient retrovirus moves around our genome and may be a risk for regenerative medicine

Peer-Reviewed Publication

KUMAMOTO UNIVERSITY

 

IMAGE: HERV-K IS EXPRESSED BY SOX2 AND MOVES ON THE GENOME THROUGH REVERSE TRANSCRIPTION AND INTEGRATION. view more 

CREDIT: DR. KAZUAKI MONDE

Using a next generation sequencing analysis to examine human endogenous retrovirus (HERV) integration sites, researchers from Kumamoto University, the National Institute of Genetics (Japan), and the University of Michigan (USA) have discovered that these ancient retroviruses can undergo retrotransposition (DNA sequence insertion with RNA mediation) into iPS cells. The team believes that their discovery places a spotlight on a possible risk that HERVs pose when using iPS cells in regenerative medicine.

The study of ancient retroviruses embedded in our genome requires knowledge about our coexistence with viral threats throughout history. We know that HERVs occupy approximately 8% of the human genome and obtain mutations and deletions over long periods. HERVs are also expressed in early embryos and play several physiological roles in human development. For example, HERV-W and HERV-FRD Env proteins are important for placental formation, and HERV-K is thought to protect host cells from exogenous retrovirus infection. However, uncontrollable HERV-K expression is also thought to be associated with various diseases, including various cancers and neurological diseases, but the details of this association is not well known in humans.

Since no one has yet discovered replication competent HERVs in our genome, it is thought that they are from an extinct (fossil) virus. In their current work, the research team from Japan and the US discovered that HERV-K is expressed in SOX2-expressing cells, such as those in early embryos, cancer stem cells and iPS cells. They also found that some HERV-K are newly integrated into the host genome in the absence of Env, the viral envelope glycoprotein. This integration was dependent on reverse transcriptase, integrase and protease, thus the researchers hypothesized that the HERV-K embedded in our genome is actually not from a fossil virus, but moves on the genome through the synthesis of proviral DNA reverse transcription. Interestingly, when the researchers compared the HERV-K integration sites between iPS and fibroblast cells from the same donor, they found new HERV-K integration sites in iPS cells. However, the new integration sites were rarely preserved and disappeared during long-term culturing. HERV-K is likely to be randomly integrated into genome, thus the possibility remains that HERV-K retrotransposed-cells predominantly survive depending on their integration site.

The movement of HERV-K on the genome might cause cancer and neurological diseases by altering the gene expression profile. The researchers believe that the risk of HERV-K transposition is low in iPS cells but suggest that monitoring HERV-K integration sites should be seriously considered to improve the safety of regenerative medicine using iPS cells.

This research was published online on 14 April 2022 in the Journal of Virology.

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JOURNAL

Journal of Virology

DOI

10.1128/jvi.00356-22 

METHOD OF RESEARCH

Experimental study

SUBJECT OF RESEARCH

Cells

ARTICLE TITLE

Movements of ancient human endogenous retroviruses detected in SOX2-expressing cells

Supermassive black holes inside of dying galaxies detected in early universe

Peer-Reviewed Publication

NATIONAL INSTITUTES OF NATURAL SCIENCES

 

IMAGE: IN THESE GALAXIES STAR FORMATION CEASED AROUND 10 BILLION YEARS AGO. (3-COLOR FALSE-COLOR COMPOSITE IMAGES COMBINING DATA FROM THE SUBARU TELESCOPE AND VISTA) view more 

CREDIT: NAOJ

An international team of astronomers used a database combining observations from the best telescopes in the world, including the Subaru Telescope, to detect the signal from the active supermassive black holes of dying galaxies in the early Universe. The appearance of these active supermassive black holes correlates with changes in the host galaxy, suggesting that a black hole could have far reaching effects on the evolution of its host galaxy.

The Milky Way Galaxy where we live includes stars of various ages, including stars still forming. But in some other galaxies, known as elliptical galaxies, all of the stars are old and about the same age. This indicates that early in their histories elliptical galaxies had a period of prolific star formation that suddenly ended. Why this star formation ceased in some galaxies but not others is not well understood. One possibility is that a supermassive black hole disrupts the gas in some galaxies, creating an environment unsuitable for star formation.

To test this theory, astronomers look at distant galaxies. Due to the finite speed of light, it takes time for light to travel across the void of space. The light we see from an object 10 billion light-years away had to travel for 10 billion years to reach Earth. Thus the light we see today shows us what the galaxy looked like when the light left that galaxy 10 billion years ago. So looking at distant galaxies is like looking back in time. But the intervening distance also means that distant galaxies look fainter, making study difficult.

To overcome these difficulties an international team led by Kei Ito at SOKENDAI in Japan used the Cosmic Evolution Survey (COSMOS) to sample galaxies 9.5-12.5 billion light-years away. COSMOS combines data taken by world leading telescopes, including the Atacama Large Millimeter/submillimeter Array (ALMA) and the Subaru Telescope. COSMOS includes radio wave, infrared light, visible light, and x-ray data.

The team first used optical and infrared data to identify two groups of galaxies: those with ongoing star formation and those where star formation has stopped. The x-ray and radio wave data signal-to-noise ratio was too weak to identify individual galaxies. So the team combined the data for different galaxies to produce higher signal to noise ratio images of “average” galaxies. In the averaged images, the team confirmed both x-ray and radio emissions for the galaxies without star formation. This is the first time such emissions have been detected for distant galaxies more than 10 billion light-years away. Furthermore, the results show that the x-ray and radio emissions are too strong to be explained by the stars in the galaxy alone, indicating the presence of an active supermassive black hole. This black hole activity signal is weaker for galaxies where star formation is ongoing.

These results show that an abrupt end in star formation in the early Universe correlates with increased supermassive black hole activity. More research is needed to determine the details of the relationship.

These results appeared as Ito et al. “COSMOS2020: Ubiquitous AGN Activity of Massive Quiescent Galaxies at 0 < z < 5 Revealed by X-Ray and Radio Stacking” in the Astrophysical Journal on April 12, 2022.

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JOURNAL

The Astrophysical Journal

DOI

10.3847/1538-4357/ac5aaf 

METHOD OF RESEARCH

Observational study

SUBJECT OF RESEARCH

Not applicable

ARTICLE TITLE

COSMOS2020: Ubiquitous AGN Activity of Massive Quiescent Galaxies at 0 < z < 5 Revealed by X-Ray and Radio Stacking

Autistic individuals have poorer health and healthcare

Peer-Reviewed Publication

UNIVERSITY OF CAMBRIDGE

Autistic individuals are more likely to have chronic mental and physical health conditions, suggests new research from the University of Cambridge. Autistic individuals also report lower quality healthcare than others. These findings, published in Molecular Autism, have important implications for the healthcare and support of autistic individuals.

Many studies indicate that autistic people are dying far younger than others, but there is a paucity of research on the health and healthcare of autistic people across the adult lifespan. While some studies have previously suggested that autistic people may have significant barriers to accessing healthcare, only a few, small studies have compared the healthcare experiences of autistic people to others.

In the largest study to date on this topic, the team at the Autism Research Centre (ARC) in Cambridge used an anonymous, self-report survey to compare the experiences of 1,285 autistic individuals to 1,364 non-autistic individuals, aged 16-96 years, from 79 different countries. 54% of participants were from the UK. The survey assessed rates of mental and physical health conditions, and the quality of healthcare experiences.

The team found that autistic people self-reported lower quality healthcare than others across 50 out of 51 items on the survey. Autistic people were far less likely to say that they could describe how their symptoms feel in their body, describe how bad their pain feels, explain what their symptoms are, and understand what their healthcare professional means when they discuss their health. Autistic people were also less likely to know what is expected of them when they go to see their healthcare professional, and to feel they are provided with appropriate support after receiving a diagnosis, of any kind.

Autistic people were over seven times more likely to report that their senses frequently overwhelm them so that they have trouble focusing on conversations with healthcare professionals. In addition, they were over three times more likely to say they frequently leave their healthcare professional’s office feeling as though they did not receive any help at all. Autistic people were also four times more likely to report experiencing shutdowns or meltdowns due to a common healthcare scenario (e.g., setting up an appointment to see a healthcare professional).

The team then created an overall ‘health inequality score’ and employed novel data analytic methods, including machine learning. Differences in healthcare experiences were stark: the models could predict whether or not a participant was autistic with 72% accuracy based only on their ‘health inequality score’. The study also found worryingly high rates of chronic physical and mental health conditions, including arthritis, breathing concerns, neurological conditions, anorexia, anxiety, ADHD, bipolar disorder, depression, insomnia, OCD, panic disorders, personality disorders, PTSD, SAD, and self-harm.

Dr Elizabeth Weir, a postdoctoral scientist at the ARC in Cambridge, and the lead researcher of the study, said: “This study should sound the alarm to healthcare professionals that their autistic patients are experiencing high rates of chronic conditions alongside difficulties with accessing healthcare. Current healthcare systems are failing to meet very fundamental needs of autistic people.”

Dr Carrie Allison, Director of Strategy at the ARC and another member of the team, added: “Healthcare systems must adapt to provide appropriate reasonable adjustments to autistic and all neurodiverse patients to ensure that they have equal access to high quality healthcare.”

Professor Sir Simon Baron-Cohen, Director of the ARC and a member of the team, said: “This study is an important step forward in understanding the issues that autistic adults are facing in relation to their health and health care, but much more research is needed. We need more research on long term outcomes of autistic people and how their health and healthcare can be improved. Clinical service providers need to ask autistic people what they need and then meet these needs.”

The research was funded by the Autism Centre of Excellence, the Rosetrees Trust, the Cambridge and Peterborough NHS Foundation Trust, the Corbin Charitable Trust, the Queen Anne’s Gate Foundation, the MRC, the Wellcome Trust and the Innovative Medicines Initiative.

Reference

Weir, E., Allison, C., & Baron-Cohen, S. Autistic adults have poorer quality healthcare and worse health based on self-report data. Molecular Autism (2022).

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JOURNAL

Molecular Autism

DOI

10.1186/s13229-022-00501-w 

METHOD OF RESEARCH

Survey

SUBJECT OF RESEARCH

People

ARTICLE TITLE

Autistic adults have poorer quality healthcare and worse health based on self-report data

ARTICLE PUBLICATION DATE

26-May-2022

A climate resilient Venice: How to meet the challenge

CMCC FOUNDATION - EURO-MEDITERRANEAN CENTER ON CLIMATE CHANGE

image: The Metropolitan City of Venice. The Case study area. view more

Credit: Image credits: CMCC - UNIVE


Increases in climate-change related impacts are giving rise to environmental, economic, and social stress on coastal systems. These climate-related threats may be exacerbated by land use transformations, urbanization, over-tourism, sociopolitical tensions, and technological innovations among others.

The Metropolitan City of Venice and its lagoon, located in the north-east of Italy, along the Adriatic coast, is a coastal-urban system that is facing multiple challenges related both to changes in global phenomena and socioeconomic dynamics.

With the aim of enhancing overall system resilience to multiple climate-related disasters and a variety of other stressors, researchers at CMCC@Ca’Foscari, the strategic partnership between CMCC Foundation and Ca’ Foscari University of Venice, have conducted a study that identifies the best risk management initiatives for the area. Given the context of high uncertainty caused by climate change, the main objective was to identify robust initiatives across a range of possible future scenarios.

The Prioritization of Resilience Initiatives for Climate-Related Disasters in the Metropolitan City of Venice study has been conducted in the context of ‘BRIDGE’, a project of great relevance for the cooperation between Italy and the United States, coordinated by Andrea Critto, Professor at Ca’Foscari University of Venice and Senior Scientist at the CMCC. It concludes that, given the situation of uncertainty, the best possible strategy is to use a portfolio of risk-management initiatives – instead of a single initiative – to enhance the resilience of the whole system. This set of measures should include physical initiatives – such as the adaptation of hydraulic defense structures to cope with large scale and intense events – together with cognitive and social initiatives – such as updating and implementation of plans and regulations – which can be flexible enough to be effective against a range of hazards.

The study integrates qualitative information – derived from the involvement of stakeholders in a workshop – and quantitative information derived from climate sciences (i.e., climate-change projections).

At first, different groups of local stakeholders, including local authorities, civil protection agencies, research institutions, parks and NGOs identified the critical components of the system (natural, cultural, social, and economic) that should be protected in the area.

Secondly, stakeholders and experts identified a set of policy initiatives to support these critical functions, divided into: Information initiatives (early warning systems and information production and sharing); physical initiatives (green and blue infrastructure networks, adaptation and optimization of the water network and supply, adaptation of hydraulic defense structures and emergency response arrangements); cognitive initiatives (updating and implementation of plans and regulations, civil protection machine planning; as well as plans and strategies for restoration and recovery of historical areas); and social initiatives (environmental education and awareness and citizen science).

Finally, the above risk management initiatives were ranked, through a scenario-informed MultiCriteria Decision Analysis (MCDA), across four scenarios describing main climate threats expected in the area: storm surges, pluvial floods, heatwaves and drought.

Results show that different climate scenarios, when analyzed individually, lead to a specific prioritization of the set of risk management initiatives. Likewise, the priority of initiatives changes when considering the joint occurrence of several scenarios. However, given the large uncertainty in predicting which hazard scenarios may occur in the future in this particular area, the best option is to build overall resilience of coastal systems in the face of a range of adverse events.

The management alternatives acting on the physical domain, despite being considered a priority by stakeholders, generally only enhance resilience across a few scenarios. These results can be explained by the fact that physical initiatives are usually designed and implemented targeting very specific typologies of extreme climate events. For example, the design of hydraulic defense structures and the implementation of emergency response arrangements including set infrastructural projects like the MOSE – (MOdulo Sperimentale Elettromeccanico) or temporary solutions (e.g. footbridges, pumps and mobile bulkheads on private buildings and doors) are specifically designed for the protection of the Metropolitan City of Venice from storm surge and high waters events, while lacking any ability to increase the system resilience in relation to other kinds of hazard, such as drought and heatwaves.

On the contrary, cognitive, informative, and social initiatives seem to be more stable under changing conditions, as they maintain their position when climate change scenarios are introduced.

Implementing initiatives strongly oriented to cope with specific hazards could lead to an increase of a risk toward other kinds of hazards (i.e., maladaptation) thus undermining efforts and resources invested for risk reduction. Accordingly, the study recommends the adoption of a portfolio of risk-management initiatives to enhance the resilience of the system. These should include physical initiatives to cope with large scale and intense events, together with cognitive and social ones which can be flexible enough to be effective against a range of hazards.

“Climate risks are interconnected and do not occur in isolation” says Silvia Torresan, co-director of the Risk Assessment and Adaptation Strategies Division at the CMCC Foundation. “If we don’t employ a multi-risk approach in the assessment and management of risks, we could adopt measures that address one problem but generate or amplify others.”



For more information:

Bonato M., Sambo B., Sperotto A., Lambert J.H., Linkov I., Critto A., Torresan S., Marcomini A.
2021, Risk Analysis: An International Journal, Risk Analysis, Vol. 0, No. 0, 2021, DOI: https://doi.org/10.1111/risa.13823

No 'echo chambers' in Reddit climate debate

Peer-Reviewed Publication

UNIVERSITY OF EXETER

Climate change debates on Reddit don't happen in polarised "echo chambers", new research suggests.

The study found evidence suggestive of more "deliberative debate".

University of Exeter researchers examined the topics, information sources and the existence of different communities in Reddit climate discussions.

They found little evidence of echo chambers – contrasting with previous research on Twitter which found discussions of climate change often occur within polarising echo chambers. 

However, the study did find evidence of polarisation, with the most common topic in climate-related posts and comments being "incivil debate" (containing name-calling and unfriendly language).

"We also found evidence suggestive of more 'deliberative debate', with lots of discussion about important aspects of the climate crisis and many topics suggestive of debate that is not incivil," said lead author Kathie Treen, from the University of Exeter.

"It was encouraging to see a lack of echo chambers, aside from a single pro-Trump community which has since been banned by Reddit.

"Even though there's polarisation in terms of opinion, the two sides are debating in the same place."

The researchers used three methods to analyse climate discussions on Reddit:

• Topic modelling (data on words commonly found together, which can reveal the subjects being discussed). This showed wide-ranging discussions on subjects including the causes and impacts of climate change, politics, economics and science. But "incivil debate" was dominant in more posts and comments than any other subject, and climate scepticism/denial was a close second.
• Community detection (which people engage with each other?). A “reply network” based on who replies to whom was used to detect communities of individuals. Mapping the interactions between these communities revealed what Treen called a "hairball" of interconnected communities. Rather than echo chambers whose members only spoke to each other, the different communities were "highly connected" (measured by the level of interaction between the different communities). 
• Analysis of sources (which sources did users cite?). The sources cited suggest an overall leaning that is somewhat left-wing politically and environmentalist in its climate perspective. Wikipedia was the most shared source, followed by YouTube and Twitter. The only traditional "expert-generated" sources in the top 10 were the Guardian and Nasa. The IPCC – the authoritative assessment of climate change information – was 35th.

Treen explained that “whilst most research on social media climate debate has focussed on Twitter, Reddit has a different platform architecture, for example community moderation and theme-based rather than follower-based information flows".

She added: “The findings of our paper suggest that platform architecture plays a key role in shaping climate debate online.”

The study used data from 1 April to 30 June 2017 – an important period in climate politics, as the US announced its withdrawal from the Paris Agreement on 1 June that year.

The researchers analysed 18,558 posts and 267,147 comments from 93,850 users related to the issue of climate change.

The paper, published in the journal Environmental Communication, is entitled: "Discussion of Climate Change on Reddit: Polarized Discourse or Deliberative Debate?"

The paper's authors include researchers working on ACCESS, a new five-year project funded by the Economic and Social Research Council that aims to provide leadership on the social science contribution to tackling and solving a range of environmental problems. It will build leadership capacity in a new cohort of early career researchers and collaborate with stakeholders to ensure social science evidence informs decision-making.

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JOURNAL

Environmental Communication

DOI

10.1080/17524032.2022.2050776 

METHOD OF RESEARCH

Data/statistical analysis

SUBJECT OF RESEARCH

People

ARTICLE TITLE

Discussion of Climate Change on Reddit: Polarized Discourse or Deliberative Debate?

Just being exposed to new things makes people ‘ready to learn’

Latent learning occurs without any explicit teaching

Peer-Reviewed Publication

OHIO STATE UNIVERSITY

COLUMBUS, Ohio – Long before they enter a classroom, people learn to identify commonplace objects like a “dog” and a “chair” just by encountering them in everyday life, with no intent to learn about what they are.

 

A new study is one of the first to provide experimental evidence that people learn from incidental exposure to things that they know nothing about and aren’t even trying to understand.

 

Exposure to new objects makes humans “ready to learn,” said Vladimir Sloutsky, co-author of the study and professor of psychology at The Ohio State University.

 

“We often observe new things out in the real world without a goal of learning about them,” Sloutsky said.

 

“But we found that simply being exposed to them makes an impression in our mind and leads us to be ready to learn about them later.”

 

Sloutsky conducted the research with Layla Unger, a postdoctoral researcher in psychology at Ohio State and lead author of the study.  The study was published May 26, 2022 in the journal Psychological Science.

 

The study included five different experiments with 438 people, with all experiments showing similar results.

 

In the studies, participants first took part in an “exposure phase” in which they played a simple computer game while seeing colorful images of unfamiliar creatures. The game did not provide any information about these creatures, but for some participants, unbeknownst to them, the creatures actually belonged to two categories – Category A and Category B.

 

Similar to real-world creatures such as dogs and cats, Category A and Category B creatures had body parts that looked somewhat different, such as different-colored tails and hands. Control group participants were shown images of other unfamiliar creatures.

 

Later in the experiment, the participants went through “explicit learning,” a process in which they were taught that the creatures belonged to two categories (called “flurps” and “jalets”), and to identify the category membership of each creature.

 

The researchers measured how long it took participants to learn the difference between Category A and Category B in this explicit learning phase.

 

“We found that learning was substantially faster for those who were exposed to the two categories of creatures earlier on than it was in the control group participants,” Unger said.

 

“Participants who received early exposure to Category A and B creatures could become familiar with their different distributions of characteristics, such as that creatures with blue tails tended to have brown hands, and creatures with orange tails tended to have green hands.  Then when the explicit learning came, it was easier to attach a label to those distributions and form the categories.”

 

In another experiment in the study, the simple computer game that participants played in the exposure phase involved hearing sounds while seeing the images of the creatures. Participants simply hit a key whenever the same sound was played two times in a row.

 

“The images were randomly attached to the sounds, so they could not help participants learn the sounds,” Sloutsky said. “In fact, the participants could completely ignore the images and it would not affect how well they did.”

 

Still, participants who were shown the images of Category A and B creatures later learned the differences between them more quickly during the explicit learning phase than participants who were shown other unrelated images.

 

“It was pure exposure to the creatures that was helping them learn faster later on,” Sloutsky said.

 

But was it possible that they had already actually learned the difference between Category A and B creatures during the early exposure, without needing the explicit learning?

 

The answer is no, Unger said.

 

In some of the studies, the simple computer game in the exposure phase involved first seeing a creature in the center of the screen. Participants were then asked to hit one key if the creature jumped to the left side of the screen and a different key if it jumped to the right, as quickly as possible.

 

Participants were not told this, but one type of creature always jumped to the left and the other always jumped to the right. So if they learned the difference between the two creature categories, they could respond faster.

 

Results showed that participants did not respond faster, suggesting they didn’t learn the difference between Category A and Category B creatures in the exposure part of the experiment.

 

But they still learned the difference between them more quickly in the explicit learning part of the experiment than those participants who were exposed to images of other creatures during the earlier exposure phase.

 

“The exposure to the creatures left participants with some latent knowledge, but they weren’t ready to tell the difference between the two categories.  They had not learned yet, but they were ready to learn,” Unger said.

 

Sloutsky said this is one of few studies that has shown evidence of latent learning.

 

“It has been very difficult to diagnose when latent learning is occurring,” he said.  “But this research was able to differentiate between latent learning and what people learn during explicit teaching.”

 

The study was funded by grants to Sloutsky from the National Institute of Child Health and Human Development.

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JOURNAL

Psychological Science

DOI

10.1177/09567976211061470 

METHOD OF RESEARCH

Experimental study

SUBJECT OF RESEARCH

People

ARTICLE TITLE

Ready to learn: Incidental exposure fosters category learning

ARTICLE PUBLICATION DATE

26-May-2022

A cushy lab life has its evolutionary costs — when it comes to fish, that is

Laboratory zebrafish have lost physiological plasticity after five decades of domestication

Peer-Reviewed Publication

NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY

 

IMAGE: FREDRIK JUTFELT, HEAD OF NTNU’S FISH ECOPHYSIOLOGY LAB, HAS STUDIED VARIOUS KINDS OF FISH, INCLUDING ZEBRAFISH. PHOTO: NTNU view more 

CREDIT: NTNU

Consider the humble zebrafish. They produce 200 embryos every 7 days, they’re cheap and easy to grow, and their young are small and transparent.  But their most important feature — at least if you are a researcher — is that they share a high degree of genetic, anatomical and physiological similarities to humans.

Ever since the Hungarian researcher George Streisinger pioneered the use of these tiny but important fish in 1972, scientists have found ways to use zebra fish to study everything from epilepsy to environmental pollutants. Researchers at the Kavli Institute of Systems Neuroscience even peer into the brains of genetically modified zebra fish to study the brain’s wiring system.

All those years of domestication — 150 generations of zebrafish, by one biologist’s count — led a team of researchers to realize they had a perfect evolutionary experiment. They wondered what had happened to laboratory zebrafish over all these generations, when it comes to a characteristic called plasticity.

“Plasticity allows organisms to adjust to different environments, for example to perform consistently across a wide range of temperatures,” said Rachael Morgan, who recently completed her PhD at the Norwegian University of Science and Technology’s Department of Biology. “But plasticity — this ability to adjust their physiology — could have a cost, in which case domesticated zebrafish, which have been raised in extremely stable conditions, should lose this plasticity over time.”

So the researchers conducted an experiment with wild and lab zebrafish to see if this was the case. Their findings have been published in the Proceedings of the National Academies of Science of the United States, PNAS.

CAPTION

The zebrafish (Danio rerio) has proved to be as invaluable a lab animal as the laboratory rat. Now it has given researchers another interesting piece of information about evolution.

CREDIT

Photo: Fredrik Jutfelt/NTNU

Stable lab temperatures reduce need to respond

Researchers generally rear their lab zebrafish at an optimal temperature of roughly 28C, which promotes healthy growth and the best fertility. Over time lab zebrafish have adapted to this, as well as to life in small aquaria with lots of other fish, dry food and handling by humans, the researchers observed in their paper.

So Morgan and her colleagues decided to compare how lab zebrafish would cope with different temperature regimes compared to wild zebrafish.

They took 300 juvenile lab zebrafish and 300 juvenile wild zebrafish and exposed them to one of 15 different temperatures for 35 days. The temperatures they selected (10-38C) were based on the range of temperatures that a wild zebrafish might be expected to experience.

After the 35-day acclimatization period both wild and lab fish were subjected to a range of tests, such as swimming activity, maximum swim speed, metabolism and growth rate, among other measures.

The results showed that across a range of measures, the lab fish had indeed lost their physiological plasticity, Morgan said.

“What we were exploring is whether there is a cost of plasticity, and if there is a cost then we would expect that plasticity would be selected against if there is no need to maintain it,” she said “And this is largely what we found. We also show that changes have occurred in many different traits and across different levels of the organism (from genetic to the whole organism) which is quite unique.”

CAPTION

Rachael Morgan is the first author of a new paper in the Proceedings of the National Academy of Science about how lab zebrafish have lost their physiological plasticity over 5 decades of being raised in fish tanks instead of living in the wild.

CREDIT

Photo: Fredrik Jutfelt/NTNU

Adapting to the environments they live in

Fredrik Jutfelt, the senior author of the paper, said the study also shows how two populations have adapted to the environments they are in through evolution.

“Lab zebrafish adapted to the narrow temperature range they experience in the lab but have lost their ability to perform so well at temperatures higher or lower than they experience,” he said. “Wild fish experience a wide temperature range and are adapted for this as they can adjust their physiology using physiological plasticity to maintain function.”

The study is also a reminder that organisms like zebrafish, which have been adopted by researchers for a range of research topics and domesticated over the decades, are not exactly the same as their wild brethren, the researchers said.

“This study also illustrates how model organisms, such as lab zebrafish, may not be an accurate representation of their wild counterparts,” Jutfelt said. “It shows how rapidly changes, in this case loss of thermal plasticity, can occur in an organism.”

Reference: Reduced physiological plasticity in a fish adapted to stable temperatures. Rachael Morgan, Anna H. Andreassen, Eirik R. Åsheim, Mette H. Finnøen, Gunnar Dresler, Tore Brembu, Adrian Loh, Joanna J. Miest, and Fredrik Jutfelt. PNAS. May 26, 2022. 119 (22) e2201919119 https://doi.org/10.1073/pnas.2201919119

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JOURNAL

Proceedings of the National Academy of Sciences

DOI

10.1073/pnas.2201919119 

METHOD OF RESEARCH

Experimental study

SUBJECT OF RESEARCH

Animals

ARTICLE TITLE

Reduced physiological plasticity in a fish adapted to stable temperatures

ARTICLE PUBLICATION DATE

26-May-2022

Art meets 5G: Digital experiments held at art museums in Turin

A significant collaboration between public and private organisations: City of Turin, Ericsson, TIM, the Turin Museum Foundation and the Italian Institute of Technology, with the contribution of Atos and Samsung

Business Announcement

ISTITUTO ITALIANO DI TECNOLOGIA - IIT

 

VIDEO: IN THE FRAMEWORK OF EU-FUNDED PROJECT 5GTOURS, R1 HUMANOID ROBOT TESTED AT GAM (TURIN) ITS ABILITY TO NAVIGATE AND INTERACT WITH VISITORS AT THE 20TH-CENTURY COLLECTIONS, ACCOMPANYING THEM TO EXPLORE A SELECTION OF THE MUSEUM’S MOST REPRESENTATIVE WORKS, SUCH AS FELICE CASORATI’S “DAPHNE A PAVAROLO”. THE ROBOT HAS BEEN DESIGNED AND DEVELOPED BY IIT, WHILE THE 5G CONNECTION WAS SET UP BY TIM USING ERICSSON TECHNOLOGY. view more 

CREDIT: IIT-ISTITUTO ITALIANO DI TECNOLOGIA/GAM

27 May, Turin (Italy) – Robotics, 5G and art: during the month of May visitors to the Turin’s art museums, Turin Civic Gallery of Modern and Contemporary Art (GAM) and Turin City Museum of Ancient Art (Palazzo Madama), had the opportunity to be part of various experiments based on 5G-network technology. Interactive technologies and robots were the focus of an innovative enjoyment of the art collections, with a great appreciation from the public.

Visitors to the GAM and to Palazzo Madama were provided with a number of engaging interactive experiences made possible through a significant collaboration between public and private organisations, which have been working together for more than three years to experiment the potential of new 5G technology in the framework of the EU-funded project 5GTours (https://5gtours.eu/).

The demonstrations set up in Turin led to the creation of innovative applications in the tourism and culture sectors that can easily be replicated in any artistic or museum context.

In both venues, visitors had the opportunity to meet R1, the humanoid robot designed by the IIT-Istituto Italiano di Tecnologia (Italian Institute of Technology) in Genova and created to operate in domestic and professional environments, whose autonomous and remote navigation system is well integrated with the bandwidth and latency offered by a 5G connection. R1, the robot - 1 metre 25 cm in height, weighing 50 kg, made 50% from plastic and 50% from carbon fibre and metal - is able to describe the works and answer questions regarding the artist or the period in history to which the work belongs. 5G connectivity is required in order to transmit the considerable quantity of data generated by the robot’s sensors and the algorithms that handle environmental perception, autonomous navigation and dialogue to external processing systems with extremely rapid response times.

At Palazzo Madama R1 humanoid robot led a guided tour of the Ceramics Room, while at GAM it was available to visitors of the twentieth-century collections, accompanying them to explore a selection of the museum’s most representative works. R1 robot explained and responded to questions about six relevant paintings: Felice Casorati’s “Daphne a Pavarolo”, Osvaldo Lucini’s “Uccello 2”, Marc Chagall’s “Dans mon pays”, Alberto Burri’s “Sacco”, Andy Warhol’s “Orange car crash” and Mario Merz’s “Che Fare?”.

Moreover, visitors - with the use of Meta Quest visors also connected to the 5G network - were required to solve a puzzle, putting the paintings in the Guards’ Room back into their frames. With these devices, the works in the hall, which in reality cannot be touched, can be handled and moved virtually. Lastly, the visitors involved had the opportunity to visit the underground spaces of Palazzo Madama with the mini-robot Double 3, which uses the 5G network to move reactively and precisely within the narrow spaces.

CAPTION

In the framework of EU-funded project 5GTours, R1 humanoid robot tested at GAM (Turin) its ability to navigate and interact with visitors at the 20th-century collections, accompanying them to explore a selection of the museum’s most representative works, such as Osvaldo Lucini’s “Uccello 2”. The robot has been designed and developed by IIT, while the 5G connection was set up by TIM using Ericsson technology.

CREDIT

IIT-Istituto Italiano di Tecnologia/GAM

At GAM a class of students from a local school were able to remotely connect and manoeuvre the mini-robot Double 3 located in the rooms of the twentieth-century collections at the GAM directly from their classroom. A treasure hunt held in the museum with the participants never leaving the school.

In the Educational Area, a group of youngsters had the opportunity of collaborating in the painting of a virtual work of art on a large technological wall, drawing inspiration from works by Nicola De Maria.

R1 humanoid robot explaining Andy Warhol’s work (VIDEO)

CAPTION

In the framework of EU-funded project 5GTours, R1 humanoid robot tested at GAM (Turin) its ability to navigate and interact with visitors at the 20th-century collections, accompanying them to explore a selection of the museum’s most representative works, such as Andy Warhol’s “Orange car crash”. The robot has been designed and developed by IIT, while the 5G connection was set up by TIM using Ericsson technology.

CREDIT

IIT-Istituto Italiano di Tecnologia/GAM

The 5G network solutions created at the GAM and at Palazzo Madama by TIM with Ericsson technology in collaboration with the City of Turin and the Turin Museum Foundation, guarantee constant high-speed transmission and extremely low latency. These solutions, which comply with 3GPP standard, are extremely flexible in terms of setting up and use. In the case of Palazzo Madama, a UNESCO World Heritage Site, tailor-made installations were designed, using apparatus and solutions that perfectly integrate with the museum spaces, while at the same time guaranteeing extremely high performance. At the GAM, the Radio Dot System has been implemented, a new 5G solution from Ericsson that is small enough to be held in the palm of a hand, and that provides network coverage and performance required for busy indoor areas. Thanks to these activities, Turin is ever increasingly playing a role as an open-air laboratory for urban innovation; since 2021 it has been the location of the “House of Emerging Technology - CTE NEXT”, a veritable centre for technology transfer via 5G and for emerging technologies coordinated by the Municipality of Turin and financed by the Ministry for Economic Development.

Through these solutions, Palazzo Madama and the GAM are now unique examples of technology in Italy and a rare example on a European level of museum buildings with full 5G coverage.

The experience was the result of the project financed by the European Union, 5G-TOURS “5G smarT mObility, media and e-health for toURists and citizenS”, the city of Turin - Department and Directorate of Innovation, in collaboration with the Department of Culture - Ericsson, TIM, the Turin Museum Foundation and the IIT-Istituto Italiano di Tecnologia (Italian Institute of Technology) of Genova, with the contribution of the international partners Atos and Samsung. The 5G coverage within the two museums was set up by TIM using Ericsson technology, solutions that perfectly integrated with the areas within the two museums structures.

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METHOD OF RESEARCH

Experimental study