Tuesday, June 07, 2022

More children died from gun violence than car crashes in 2020. Are school shootings to blame?

flowers candles memorial
Credit: Unsplash/CC0 Public Domain

Gun-related deaths have overtaken auto accidents as the leading cause of death of children in the United States, The New England Journal of Medicine reported in May.

The 45,222  in 2020—"a new peak," according to NEJM—was a 13.5% increase from 2019, and is largely attributed to an increase in homicides rather than suicides. Of the deaths, 10% were children ages 1 to 19, making 2020 the first year that firearms were more deadly for children than auto accidents.

In light of the recent string of  in the United States, including the horrifying murders of 19 children and two teachers at Robb Elementary School in May, it may be tempting to attribute this development to mass shootings. But Northeastern researchers say that doing so is a misunderstanding of the real risks involved with  in the United States.

The general increase in  between 2019 and 2020 is somewhat of a mystery.

"In general, 2020 was sort of an unprecedented year for increases in homicides, particularly firearm homicides," says Matthew Miller, professor at Northeastern's Bouvé College of Health Sciences.

But, he says, "Nobody knows why."

There are many theories that could explain the increase in overall gun deaths, including shifts in policing after the George Floyd murder, or increased stress during the COVID-19 pandemic. But there is no definitive explanation for it, Miller says—and strangely, crime didn't rise.

"It's not that we have a crime problem over the last year or so, it's a lethal violence problem," Miller says.

Auto deaths, on the other hand, have been trending down since the mid-20th century, making the overlap with firearm deaths almost an inevitability. Miller calls the drop in auto deaths "a huge public health success story."

Over the past half century, he says, data from car crashes in the United States has been used to determine trends and eliminate risks. For example, over the years, trees on the side of the highway have been replaced with ditches. Cars are now manufactured with  in place, and as older models are taken off the road, driving becomes less deadly, Miller says.

The same can't be said of the country's rate of gun deaths, which trumps that of any other high-income country, Miller says. The United States is comparable to those countries when it comes to crime, Miller says, and even when it comes to violence. The difference, though, is that the tools that are used in the United States are more deadly.

"When we're violent, it's easy for us to reach for guns," he says. "And so it's easier for people to die."

In addition,  are far more common in the United States than other high-income countries, Miller says.

And yet, according to James Alan Fox, a criminologist at Northeastern University and an international expert on , the risk of school shootings in the United States is vastly overstated relative to other forms of gun violence.

"The average number of children who are killed at school by guns in an average year is about seven," he says.

If this figure seems low, it may be because of the media's inflated response to mass shootings, which Fox says can mislead the public about how gun violence usually happens. While the media might call mass shootings an "epidemic," Fox says deaths from mass shootings actually form "a small fraction of all the gun homicides in this country."

The confusion is in part due to the varying definitions of mass shootings. On June 3, The Washington Post published an article titled "Mass shootings in 2022: US sees more than 200 so far"—here, "mass " is defined as four people or more shot. On the same day, the New York Times published "At Least 18 Mass Shootings Have Happened in the U.S. So Far This Year," defining a mass shooting as an incident where "at least three people" were killed.

Citing hundreds of mass shootings per year obscures how few of those who die from guns are dying in mass shootings, Fox says. According to data from the Gun Violence Archive, of the 233 mass shootings this year, 89 resulted in zero deaths, and 90 resulted in one death. The same dataset shows that the 261 deaths from mass shootings this year form a mere 1.42% of the 18,320 gun deaths in 2022. Moreover, Fox says, the public mass shootings that receive the most media attention are also a minority of the cases of mass shootings, which include domestic shootings and gang violence.

"People get confused and think it's an epidemic," Fox says. "It's not."

Rather, he says, "A large share of [shootings] are gang shootings, shootings over drug trafficking, shootings in the family," Fox says, "not public places."

To support this, he notes that the statistic about child deaths in the U.S. includes teens aged 15 to 19, who accounted for 83% of the child deaths in 2020.

Despite the truth about gun violence, though, "there tends to be inflated coverage," around school shootings, and this can influence how the public perceives risk, says Susan Mello, an assistant professor of communication studies at Northeastern.

"If you put it on an objective spectrum of what actually are risks to society, these school shootings are low," Mello says.

But public perceptions of risk don't always match reality. For example, the public's perception of the risks of driving is "astronomically low compared to what they actually are," Mello says. "Because it's become such an integrated part of our lives, we're desensitized to the actual objective risk. We've just come to accept it as part of our life, unfortunately."

Still, "It would be a mistake to say that guns aren't a huge risk," Mello says, citing the risk of having a gun in the home. "The percentage of kids who are in households in the United States where there are guns that are not locked up is horrifying," she says.

This misunderstanding of gun risks means that measures that are taken or proposed after a well publicized school shooting may actually be counterproductive. For example, Miller says that gun purchases actually go up after school shootings, something that is more likely to put families in danger rather than protecting them. Proposed measures like arming teachers and locking classrooms from the inside also add risk, Fox says. Moreover, he says, school shooting drills can actually traumatize children, and he recommends simply talking to children.

Instead, Miller would like to see guns become much more difficult to acquire, by raising the age of purchasing, starting buyback programs, and banning assault weapons altogether.

"Then you'd see a big decline in suicide rates, and you'd see a decline in murder rates," he says.

For his part, Fox says universal background checks will help reduce general gun violence. While this won't solve the problem of mass shootings—most public mass shooters, he says, obtain their guns legally—it would help stem the tide of more common gun violence.

Unfortunately, neither Fox nor Miller is optimistic that big measures can be taken in the current political climate.

"The fact of the matter is that we have about 350 million guns in the country, and there's no quick fix for that," Fox says.Research team uncovers changes in the people and places impacted by interpersonal firearm violence following COVID-19

More information: Jason E. Goldstick et al, Current Causes of Death in Children and Adolescents in the United States, New England Journal of Medicine (2022). DOI: 10.1056/NEJMc2201761

Journal information: New England Journal of Medicine 

Provided by Northeastern University 

 

Bacterial cellulose in kombucha enables microbial life under Mars-like conditions

Bacterial cellulose enables microbial life on Mars
Section of the EXPOSE-2 platform outside the International Space Station (ISS) 
simulating a Mars-like environment that was used for the experiments. 
Credit: European Space Agency (ESA)

An international research team including the University of Göttingen has investigated the chances of survival of kombucha cultures under Mars-like conditions. Kombucha is known as a drink, sometimes called tea fungus or mushroom tea, which is produced by fermenting sugared tea using kombucha cultures—a symbiotic culture of bacteria and yeast. Although the simulated Martian environment destroyed the microbial ecology of the kombucha cultures, surprisingly, a cellulose-producing bacterial species survived. The results were published in Frontiers in Microbiology.

The scientists of the "Biology and Mars Experiment" (BIOMEX) project had already sent kombucha cultures to the International Space Station (ISS) in 2014 with the support of the European Space Agency. The aim was to learn more about the robustness of cellulose as a biomarker, the genomic architecture of kombucha, and its survival behavior under extraterrestrial conditions. After one and a half years under simulated Martian conditions outside the ISS, the samples were reactivated on Earth and cultivated for another two and a half years.

The head of the University of Göttingen's Institute of Veterinary Medicine, Professor Bertram Brenig, was responsible for the sequencing and bioinformatic analysis of the metagenomes of the reactivated cultures and individual kombucha cultures in a team with researchers from the University of Minas Gerais in Brazil. "Based on our metagenomic analysis, we found that the simulated Martian environment drastically disrupted the microbial ecology of kombucha cultures. However, we were surprised to discover that the cellulose-producing bacteria of the genus Komagataeibacter survived."

Bacterial cellulose in kombucha enables microbial life under Mars-like conditions
Another platform (EXPOSE-R2) outside the International Space Station (ISS) for
 simulating a Mars-like environment that was used for the experiments.
 Credit: European Space Agency (ESA)

The results suggest that the cellulose produced by the bacteria is probably responsible for their survival in extraterrestrial conditions. This also provides the first evidence that bacterial cellulose could be a biomarker for  and cellulose-based membranes or films could be a good biomaterial for protecting life and producing consumer goods in extraterrestrial settlements.

Another interesting aspect of these experiments could be the development of novel drug delivery systems (for example, the development of medicine suitable for use in space). Another focus was on investigations into changes in antibiotic resistance: the research team was able to show that the total number of antibiotic and metal resistance genes—meaning that these microorganisms might survive despite antibiotics or metals in the environment—were enriched in the exposed cultures. "This result shows that the difficulties associated with  in medicine in space should be given special attention in the future," the scientists saidSpace Kombucha in the search for life and its origin

More information: Daniel Santana de Carvalho et al, The Space-Exposed Kombucha Microbial Community Member Komagataeibacter oboediens Showed Only Minor Changes in Its Genome After Reactivation on Earth, Frontiers in Microbiology (2022). DOI: 10.3389/fmicb.2022.782175

Provided by University of Göttingen 

 

Study of Indonesian protected marine areas suggests participation by Indigenous people more effective than penalties

Study of Indonesian protected marine areas suggests participation by indigenous people more effective than penalties
Location of ecological sites and settlements across the Bird's Head Seascape. Ecological
 treatment sites (n = 59) are represented by white circles, ecological control sites (n = 28)
 are represented by green circles, and settlement sites (n = 32) are represented by yellow
 diamonds. MPAs are bounded in blue. 
Credit: Science Advances (2022). DOI: 10.1126/sciadv.abl8929

A team of researchers affiliated with multiple entities in Indonesia and the U.S. has found that allowing Indigenous people to participate in management of protected marine areas is more effective than simply assessing penalties for violators. In their paper published in the journal Science Advances, the group describes their study of the volume of biomass in several parts of Bird's Head Seascape in Indonesia, which is part of what is known as the Coral Triangle.

Over the past several years, officials in Indonesia have recognized the need to protect parts of the sea surrounding their many-islanded nation. To that end, they have designated some areas as wholly protected and others as multiuse marine protected areas (MPAs), which means that they are protected in general, but fishing and some other activities by some people is allowed. Also, some MPAs are protected by laws that prohibit certain activities such as taking more than a certain number of fish; other MPAs are protected by the Indigenous people that live there. In this new effort, the researchers looked at the two approaches to determine which works best.

The approach involved analyzing a decade's worth of data from entities working in the Bird's Head Seascape area. The data covered hundreds of sites in four specific MPAs where fishing by Indigenous people is allowed. To measure the degree of protection at a given site, the team used the amount of fish biomass—the total mass of all the fish in a given area. Biomass measurements were obtained via questionnaires, discarded fishing equipment and camera surveillance. The team then compared the total biomass in a given area over time with the way the area was managed—by penalties or by Indigenous people running things.

The researchers found larger sustained amounts of biomass in areas controlled by Indigenous people compared to those controlled by  doling out penalties for infractions. The researchers suggest that allowing Indigenous people to manage MPAs is a better approach than heavy-handed penalties. They further suggest that more MPAs should be handed over to Indigenous people as a means for protecting  throughout Indonesia—and perhaps other parts of the world.Overfishing and other human pressures are severely harming marine protected areas worldwide

More information: Robert Y. Fidler et al, Participation, not penalties: Community involvement and equitable governance contribute to more effective multiuse protected areas, Science Advances (2022). DOI: 10.1126/sciadv.abl892

Journal information: Science Advances 

© 2022 Science X Network

The mandate effect: Official mandates can motivate the vaccine-hesitant to seek vaccination

The mandate effect
Charts show the increase in COVID-19 vaccine uptake following the 
announcement of mandates for proof of vaccination to use certain public 
spaces. Credit: ©2022 Shigeoka et al.

Public health authorities seek to increase vaccine uptake, especially among those who are hesitant. But there is little evidence as to the best way to achieve this. New research suggests that rather than direct incentives, such as money, government-imposed mandates requiring vaccination to access certain public spaces could be the key. To explore this, researchers used the variation in the dates of mandates and subsequent COVID-19 vaccine uptake across Canadian provinces and European countries.

The COVID-19 pandemic has been a trying time for everyone. Amongst the challenges facing public health authorities around the world is the struggle to vaccinate as many people as possible in order to slow the spread of the virus. Although the majority of people do seem to realize the benefits of vaccination, people vary in how urgently they seek vaccination or in how hesitant they might be to vaccinate at all.

Different ways to encourage people to vaccinate have been suggested and tried, including public awareness campaigns and even financial incentives. But Professor Hitoshi Shigeoka from the Graduate School of Public Policy at the University of Tokyo and his international team have studied the impact of  mandates—requirements for proof of vaccination to use certain  and amenities—and found those might be more effective at persuading people to vaccinate.

"Despite the proven benefits of vaccination, uptake in many countries slowed in the summer of 2021, so naturally  wished to reverse that," said Shigeoka. "Previously, we investigated the effectiveness of mask mandates and found that those did lead to a reduction of cases. To follow up, we thought there might be a relationship between vaccine mandates and the uptake of vaccinations. Provinces in Canada, as well as the European countries of France, Italy and Germany, all issued mandates at different times and also had national vaccination programs. So we looked into what happened around and after the time the mandates came into effect or were announced."

Shigeoka and his team used a  called difference in differences to explore potential connections between mandates and vaccine uptake. Since the timing of the announcement of vaccination mandates differs across 10 provinces in Canada, ranging from early August 2021 (Quebec) to late September 2021 (Prince Edward Island), they used the provinces that had not yet announced vaccine mandates as the control groups for those which had already announced mandates.

"We knew there was increased uptake following the mandates, but something that surprised us was how much the mere announcement of mandates rather than their actual implementation boosted vaccination rates," said Shigeoka.

It's important to note that although this kind of data analysis about the effect of mandates is important for public health authorities, there are other related issues such as ethics, economics, politics, and other factors, which were not a part of this study.

The study is published in Nature Human Behaviour.

Vaccine hesitancy hardens in richer countries
More information: Alexander Karaivanov, COVID-19 vaccination mandates and vaccine uptake, Nature Human Behaviour (2022). DOI: 10.1038/s41562-022-01363-1. www.nature.com/articles/s41562-022-01363-1
Journal information: Nature Human Behaviour 
Provided by University of Tokyo 

The link between temperature, dehydration and tectonic tremors in Alaska

The link between temperature, dehydration and tectonic tremors in Alaska
Figure 1: Tectonic map of the Alaska subduction zone.The thick blue solid line outlines the 
Yakutat terrane. The white circle indicates the epicentre of the low-frequency tectonic
 tremors, and the light blue dashed line shows the area where the tectonic tremors 
occurred, which is used in Figures 2 to 4. The area inside the pink dashed box is the
 model region used in this study, and the pink dashed line down the center of the box
 divides the model region into northeast and southwest areas, and represents the 
boundary between the subducted Yakutat terrane and the subducted Pacific plate in the
 model. The black lines indicate the isodepth contours of the upper surface of the subducted
 oceanic plate (with a contour interval of 20 km), red arrows show the plate motion velocity
 in the Aleutian Trench, and the red triangles indicate volcanoes. Credit: Kobe University

A Kobe University research group has shed light on how low-frequency tectonic tremors occur; these findings will contribute towards better predictions of future megathrust earthquakes.

In addition to the subducting Pacific plate, the Alaska  zone is also characterized by a subducting oceanic plateau called the Yakutat terrane. Low-frequency tectonic tremors, which are a type of slow , have only been detected in the subducted Yakutat terrane area. However, the mechanism by which these events occur is not well understood.

Researchers at Kobe University performed a 3D numerical thermomechanical simulation of thermal convection in the Alaska subduction zone with the aim of revealing the mechanism behind these low-frequency tremors. Based on the 3D thermal structure obtained from the simulation, and the indications of hydrous minerals contained in the slab, the researchers calculated the water content distribution and compared the results of these calculations in the area where the tremors occur.

The results revealed high levels of  in the marine sediment layers and  in the earthquake region. The researchers believe that the reason the tremors only occur in the Yakutat terrane is because the marine sediment layers and ocean crust are thicker there, which means that the level of dehydration is higher than in the western adjacent Pacific plate (where tectonic tremors don't occur).

The link between temperature, dehydration and tectonic tremors in Alaska
Figure 2: Temperature distribution in the slab.The temperature distribution is only plotted in
 the region where the depth of the slab surface is shallower than the bottom of the model
 (200 km), with a contour interval of 100 °C. The white line indicates the area where 
low-frequency tectonic tremors occur, as shown in Figure 1. (a) The slab surface (0 km). 
(b) 6 km depth from the slab surface. (c) 10 km depth from the slab surface.
 Credit: Kobe University

The Kobe University research group consisted of second-year master's student Iwamoto Kaya (Department of Planetology, Graduate School of Science), Academic Researcher Suenaga Nobuaki and Professor Yoshida Shoichi (both of the Research Center for Urban Safety and Security).

These results were published in Scientific Reports.

Main points

Elucidating the mechanism by which low-frequency tremors occur is important for understanding the plate subduction process. It is believed that this will also help illuminate how shallower megathrust earthquakes occur.

In this study, the research group constructed a 3D thermomechanical model of the Alaska subduction zone and calculated the subducting plate's maximum water content and level of dehydration.

The dehydration levels from the subducting plate's marine sediment layers and ocean crust were highest in the region where low-frequency tremors occur. Therefore, it is thought that the water expelled from the subducted plate contributes towards the occurrence of these tectonic tremors.

The link between temperature, dehydration and tectonic tremors in Alaska
Figure 3: The distribution of the slab’s dehydration gradient.The dehydration gradient 
refers to the water content per unit length in the subduction direction of the plate. 
The dehydration gradient distribution is plotted only in the region where the depth of the 
slab surface is shallower than the bottom of the model (200 km) and where the temperature
 is higher than 200 °C (for which phase diagram data exists). The white line indicates the 
area where low- frequency tectonic tremors occur, as shown in Figure 1. (a) The slab 
surface (0 km). (b) 6 km depth from the slab surface. (c) 10 km depth from the slab 
surface. Credit: Kobe University

Research background

An oceanic plateau called the Yakutat terrane is subducting in the Alaska subduction zone. Low-frequency tectonic tremors occur at this subducting plateau. The region where slow earthquakes (such as low-frequency tectonic tremors) occur is deeper and adjacent to the area where megathrust earthquakes occur, which suggests a connection between the two. Revealing the mechanism behind how low-frequency tectonic tremors occur is therefore important for understanding the occurrence of various earthquake events in subduction zones. This research group constructed a 3D thermomechanical model of the Alaska subduction zone so that they could investigate the temperature and level of dehydration in the areas near where low- frequency tremors occur.

Research methodology

The researchers performed a 3D numerical thermomechanical simulation in accordance with the subduction of the Yakutat terrane and Pacific plate in the Alaska subduction zone. It is thought that as the Pacific plate subducts, it brings the hydrous minerals in the slab into the deep high temperature and high pressure regions, and these conditions cause a dehydration reaction where water is expelled from the hydrous minerals.

Based on the 3D thermal structure obtained from the numerical simulation, the researchers determined dehydration levels of the hydrous minerals in the slab. From these results, it was understood that in the region where low- frequency tremors occur, a large amount of water is expelled due to the high temperature and high pressure conditions that cause the dehydration degradation reactions. It is thought that low frequency earthquakes don't occur in the Pacific plate because it has thin layers and therefore experiences little dehydration. On the other hand, the Yakutat terrane's ocean crust and marine sediment layers are comparatively thicker, meaning that it experiences high levels of dehydration. The researchers concluded that this is why low-frequency tectonic tremors only occur in the Yakutat terrane.

The link between temperature, dehydration and tectonic tremors in Alaska
Figure 4: The total sum of the dehydration gradient from the marine sediment layers and 
 ocean crust.The black box indicates the modelled area. The vertical sum of the dehydration
 gradient is only plotted for the region where the depth of the slab surface is shallower than
 the bottom of the model (200 km) and where the temperature is higher than 200 °C 
(for which phase diagram data exists). The white line indicates the area where
 low-frequency tectonic tremors occur, as shown in Figure 1. Credit: Kobe University

Further research

In 1964, a megathrust earthquake occurred in Alaska. This is the biggest earthquake that has occurred in the Alaska subduction zone and the second most powerful earthquake recorded in world history. The low-frequency tectonic tremors that were the subject of this research occur close to the epicenter of the 1964 earthquake, at the downdip of the plate interface.

Next, the research group will continue to make thermomechanical models of various  to search for universal and regional characteristics of the causal mechanisms behind undersea megathrust earthquakes and slow earthquakes. This research will contribute towards improving understanding of how earthquakes occur and our ability to predict future megathrust earthquakes.Weird earthquake reveals hidden mechanism

More information: Kaya Iwamoto et al, Relationship between tectonic tremors and 3-D distributions of thermal structure and dehydration in the Alaska subduction zone, Scientific Reports (2022). DOI: 10.1038/s41598-022-10113-2

Journal information: Scientific Reports 

Provided by Kobe University 

Scaling new heights with new research showing how plants can grow at altitude

Peer-Reviewed Publication

UNIVERSITY OF NOTTINGHAM

Image of plants growing at altitude in Ecuador 

IMAGE: IMAGE TAKEN DURING RESEARCH OF PLANTS GROWING AT ALTITUDE IN ECUADOR view more 

CREDIT: CRISTIAN MIÑO

A new study has found that plant species are adapted to the altitude where they grow by ‘sensing’ the oxygen levels that surround them.

Altitude is an important part of plant ecology with at least 30% of plant species diversity contained in mountains and climate change is leading to the retreat of alpine species and some crops to higher altitudes. 

Research led by scientists at the University of Nottingham has identified a mechanism through which plants can sense atmospheric oxygen levels (that decrease with altitude) that will help to understand how plants live at high altitude. The work was carried out in collaboration with scientists in Spain and Ecuador and was funded by the Leverhulme Trust. Their findings have been published today in Nature.

Researchers analysed plants growing at low and high-altitude locations. The team, working in Nottingham, Ecuador and Spain was able to identify how oxygen-sensing controls the pathway of chlorophyll synthesis, permitting plants to match the levels of a key toxic chemical to surrounding oxygen levels. 

Climate change is leading to the displacement of wild species and crops (for example coffee) to higher altitudes, this research offers new insights into the underlying genetic mechanisms controlling their ability to survive at different altitudes. This new understanding of the genetic changes plants go through at altitude could lead to approaches to help plant breeders enhance the capacity of crops to grow at higher altitudes.

The research was led by Professor Michael Holdsworth from the University of Nottingham in collaboration with Professor Karina Proaño at ESPE University in Sangolquí, Ecuador and Professor Carlos Alonso Blanco from the Spanish National Centre for Biotechnology CSIC.

Professor Holdsworth commented: “Altitude is a key component of ecology with different altitudes subjecting plants to changing environments, some components of which are fixed by altitude and others that are not. For life at high altitude, it was previously considered that plants need to adapt to many variables, including high UV light and lower temperatures usually present at high altitude but this study is the first time that perception of atmospheric oxygen levels has been shown to be a key determinant of altitude adaptation in plants. “

He continues: “Exploring this novel finding allowed us to show that atmospheric oxygen level is the key determinant of altitude perception. We define the molecular pathway through which oxygen-sensing results in an adapted phenotype and we find that distinct species of flowering plants are adapted to absolute altitude through conserved oxygen-sensing control of chlorophyll synthesis and hypoxia gene expression. Showing that this mechanism works in diverse species provides a new paradigm for plant ecology.”

Since its foundation in 1925, the Leverhulme Trust has provided grants and scholarships for research and education. Today it is one of the largest all-subject providers of funding for research projects, fellowships, studentships, bursaries and prizes in the UK, currently distributing £100 million each year. Awards are made in the responsive mode, with the choice of topic and research design left with applicants. Particular value is placed on research that crosses disciplinary boundaries or that is willing to take risks in its pursuit of new knowledge or understanding. 

 

New type of triterpenes discovered

Discovery in fungi overturns current knowledge of highly useful compound, opening up new world for drug discovery

Peer-Reviewed Publication

UNIVERSITY OF TOKYO

Novel pathway for the biosynthesis of triterpenes 

IMAGE: THIS FIGURE SHOWS THE DIFFERENCE BETWEEN THE PREVIOUS AND ONLY KNOWN WAY OF TRITERPENE BIOSYNTHESIS, COMPARED TO THE NEW PATHWAY WHICH THE RESEARCHERS UNCOVERED. view more 

CREDIT: IKURO ABE, 2022

A remarkable discovery and collaborative effort have revealed a new type of triterpenes, a group of organic compounds which are an important source of many medicines. Until now, all triterpenes were believed to be derived from squalene, itself a type of triterpene. However, for the very first time, researchers witnessed biosynthesis, the formation of complex compounds from simple ones in living organisms, of triterpenes in fungi without the use of squalene. This important discovery opens up a whole new world of possibilities for pharmaceutical science.

Triterpenes are organic compounds which are abundantly found in animals, plants, microorganisms and even us. About 20,000 different triterpenes have been found and they are widely used in cosmetics, food supplements and, most importantly, medicine, thanks to their anti-inflammatory, anti-cancer, anti-diabetic and other valuable properties. Until now, all known triterpenes were thought to be generated from a common precursor or source, squalene.

However, as revealed in Nature, a collaborative effort among the University of Tokyo and KEK in Japan, Wuhan University in China and Bonn University in Germany, has found a new type of triterpenes that doesn’t require squalene

“Nobody could have imagined this happening in nature. This is the discovery of a new biosynthetic machine,” explained Professor Ikuro Abe from the Graduate School of Pharmaceutical Sciences at the University of Tokyo.

Often, multiple enzyme reactions are needed to create complex molecular compounds, such as when our bodies use squalene to create hormones and bile acid. However, in just a single enzyme reaction, a simple molecule called a C5 isoprene unit, or building block, was the starter to construct a very complex triterpene molecular structure.

The discovery happened almost by accident by the team at Wuhan University, who were working on genome mining to find new natural products. They were not necessarily searching for triterpenes, but they found new genes widely distributed in fungi. “They didn’t know the genes’ function,” said Abe. “So they did a characterization of these news genes, and one of them happened to be triterpene synthesis.”

That is when they asked the other teams to get involved. According to Abe, the team at Bonn University are good at chemistry, so they worked on elucidating the detailed enzyme reaction mechanism, and researchers at the University of Tokyo and KEK applied their expertise in structural analysis. He said that once you understand the structure, you can modify it. “Change something here or there and see what happens. We can understand the structure-function relationship. It’s like a puzzle,” he explained.

“Chemistry in nature is more efficient than the chemical synthesis we use in industry. That is why we are interested in the biosynthetic processes done in nature,” Abe said. “Nature’s method is a better, cheaper and cleaner process. We are trying to better understand how processes take place in nature so that we can recreate or redesign it in the lab, to get more and more important and useful compounds.”

This new discovery is only the beginning. “Now that we have solved the protein structure, we are already manipulating the biosynthetic machinery to try to produce more useful molecules, for example, for drug development,” Abe said 

###

Journal article

Hui Tao, Lukas Lauterbach, Guangkai Bian, Rong Chen, Anwei Hou, Takahiro Mori, Shu Cheng, Ben Hu, Li Lu, Xin Mu, Min Li, Naruhiko Adachi, Masato Kawasaki, Toshio Moriya, Toshiya Senda, Xinghuan Wang, Zixin Deng, Ikuro Abe, Jeroen S. Dickschat, Tiangang Liu “Discovery of non-squalene triterpenes” Nature DOI: 10.1038/s41586-022-04773-3 / URL: https://www.nature.com/articles/s41586-022-04773-3


Funding

This study was funded by The Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan (JSPS KAKENHI Grant Number JP16H06443, JP19K15703, JP20H00490, JP20KK0173, JP21K18246), the New Energy and Industrial Technology Development Organization (NEDO, Grant Number JPNP20011), and AMED (Grant Number JP21ak0101164). This work was also supported in part by Platform Project for Supporting Drug Discovery and Life Science Research (Basis of Supporting Innovative Drug Discovery and Life Science Research) from AMED (JP21am0101071 (support number 1553)).

 

Useful Links

Link to paper: https://www.nature.com/articles/s41586-022-04773-3

Link to Lab: https://tennen.f.u-tokyo.ac.jp/index-e.html  

About the University of Tokyo


The University of Tokyo is Japan's leading university and one of the world's top research universities. The vast research output of some 6,000 researchers is published in the world's top journals across the arts and sciences. Our vibrant student body of around 15,000 undergraduate and 15,000 graduate students includes over 4,000 international students. Find out more at www.u-tokyo.ac.jp/en/ or follow us on Twitter at @UTokyo_News_en.

 

Racial, ethnic disparities in buprenorphine, naltrexone prescriptions during COVID-19

JAMA Network Open

Peer-Reviewed Publication

JAMA NETWORK

About The Study: The findings of this analysis suggest that the COVID-19 pandemic may have been associated with worsened disparities in filled buprenorphine and naltrexone prescriptions for opioid use disorder among members of racial and ethnic minority groups compared with white patients.

Authors: Sumedha Gupta, Ph.D., of Indiana University-Purdue University Indianapolis, is the corresponding author.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ 

(doi:10.1001/jamanetworkopen.2022.14765)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

National deficit of Black, Hispanic physicians, estimates of time to reach equal representation

JAMA Network Open

Peer-Reviewed Publication

JAMA NETWORK

About The Study: Researchers compared the demographics of the U.S. population with the demographics of the physician workforce and estimated rates at which medical school matriculation would have to increase for Black and Hispanic medical students to reach equal representation in the workforce.

Authors: Hector Mora, M.D., of the Hospital of the University of Pennsylvania in Philadelphia, is the corresponding author.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ 

(doi:10.1001/jamanetworkopen.2022.15485)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2022.15485?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=060122

About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.