Sunday, July 24, 2022

UK

Why doctors are angry about their 4.5 per cent “pay rise”

    

According to Health Secretary Humza Yousaf, the pay “uplift”                                                                            of 4.5 per cent, backdated to April “demonstrates that we value all our medical and dental staff”.

To BMA Scotland, the award demonstrated exactly the opposite and was condemned as “hugely disappointing”.

The 4.5% rate meets the recommendations of the Doctors and Dentists Pay Review Body, which advises the UK and devolved governments, and is more generous than it might have been.

The Department of Health had proposed a two per cent uplift for doctors and dentists in England, while the Scottish Government’s sums would have equated to a basic salary increase of £700 for a junior doctor or £500 for a consultant.

READ MORE: Can we really say the NHS is in ‘recovery’ from Covid when activity has barely changed? 

Instead, the basic pay for a first-year junior doctor on NHS Scotland will increase by £1,191 to £27,653, while the starting salary for a consultant will increase by £3,939 to £91,473. Overall, it adds £77 million to the annual NHS pay bill in Scotland.

The UK Government had warned that unaffordable pay awards would “lead to a reduced ability to expand clinical capacity and tackle the elective care backlog”, but the DDPRB cautioned: “pay awards that are too low have the potential to have significant budgetary downsides, including increased use of temporary staffing, understaffing and worse motivation, which can affect the quality of patient care and efficiency of services and undermine any budgetary benefit that lower pay awards might bring”.

Tuesday’s pay award is far from the end of the story, however; if anything it fired the starting gun on an increasingly bitter battle between health trade unions and ministers across the UK.

For medics, the bottom line is that a “pay rise” of 4.5% will be wiped out by inflation running at 9.1 to 11.1% (depending which measure you use); in this sense then, it represents a substantial pay cut.

What’s more, it comes on the back of a decade of successive real-terms pay cuts. A previous analysis by think tank, Nuffield Health, found that – based on consumer price index (CPI) inflation – average earnings for doctors in the UK actually fell by 9.1% between 2010 and 2019.

HeraldScotland: Source: Nuffield HealthSource: Nuffield Health

Having endured the pandemic, they emerge only to face record-breaking elective care backlogs, staff shortages, and a year-round winter crisis in A&E, with their incomes eroded further by rampant inflation at a time when senior clinicians also continue to be hit with punitive pension tax bills.

To paraphrase anchorman Howard Beale, doctors are “mad as hell and they’re not going to take this anymore”.

In England, BMA members have voted for “full pay restoration” – equivalent to a 30% increase in pay for consultants over the next five years that would bring salaries back into line with 2008 levels, based on retail price index (RPI) inflation.

READ MORE: Call to bring back free Covid tests amid warning NHS ‘ceasing to function’

The BMA, including BMA Scotland, had urged the DDPRB to recommend uplifts of RPI plus 2% in the current year: a 13.1% increase that would have taken the salary of a first-year junior doctor in Scotland to just under £30,000 and the starting salary of a consultant to £99,000.

Speaking last week, Professor Philip Banfield, the newly appointed chair of the BMA, said industrial action by medics in England is “almost inevitable”, with strikes by junior doctors most likely in the Spring.

HeraldScotland: The experience of the pandemic has been blamed for contributing to 'burnout' among doctors, with problems exacerbated by current backlogsThe experience of the pandemic has been blamed for contributing to ‘burnout’ among doctors, with problems exacerbated by current backlogs

North of the border, BMA Scotland has begun consulting members on “how we should respond” to the pay award. 

“It will be entirely up to the membership across the profession about what level of action they might consider taking in response,” Dr Lewis Morrison, chair of the BMA in Scotland, told the Herald.

“Regardless of the question on industrial action, what we know for sure is that burnt out staff are already taking their own individual decisions to leave the NHS in Scotland.

“This is the last thing we need right now, with rising waiting times, delays across the whole system and an NHS that is beyond breakpoint.”

It comes against a backdrop of a wider threat of industrial action by nurses, midwives and other healthcare workers, such as physiotherapists, over their 5% pay offer.

For its part, the DDPRB acknowledged the effects of inflation but noted that “employers across the economy are not matching current high levels of inflation with their pay awards”, adding: “We do not believe that doctors and dentists should necessarily be exceptionally shielded from these increases to the cost of living faced by the wider population this year.”

Its report shows that in 2010/11, the average total annual earnings of consultants put them within the 98-99th income percentile when compared against all full-time employees across the wider economy.

HeraldScotland: Source: DDPRB *NB: data relates to doctors' pay for England, but salaries broadly similar in ScotlandSource: DDPRB *NB: data relates to doctors’ pay for England, but salaries broadly similar in Scotland

By 2020/21, this position was unchanged – they remained among the 98/99 percentile of top earners.

Of course, all that really tells us is that real-terms pay cuts have been hitting workers across the board.

Set against comparator professions, however, a first-year junior doctor earns more than a vet a the same grade, while consultants’ median earnings in 2021 exceeded the highest-paid vets and university academics, but lagged “substantially” behind equivalent senior professionals in finance, accounting or legal careers, for example.

And while down, half (49.8%) of the 47,000 medical and dental staff surveyed in 2021 reported being ‘satisfied’ or ‘very satisfied’ with their pay – ranging from 34.5% among trainees to 59.6% of consultants.

It is difficult to gauge, then, what the appetite for industrial action might be, or what form it might take.

READ MORE: Record numbers spend over 12 hours in A&E 

Walkouts by doctors in Scotland are almost unheard of; in the UK as a whole, the only recent example was junior doctors striking in England in 2016 in protest over contracts. 

Research by Imperial College London found that the action had a “significant impact on care”, including over 100,000 outpatient appointment cancellations and more than 25,000 fewer planned admissions than expected – though “no obvious change in the death rate”.

Bizarrely, there is some evidence that strikes by doctors can actually correlate with a reduction mortality.

An analysis of five walkouts lasting nine days to 17 weeks by doctors around the world, from 1976 to 2003, found no associated increase in deaths; population mortality either stayed the same, or fell.

The findings, published in the journal ‘Social Science and Medicine’ in 2008, seem counterintuitive until you delve deeper.

For example, in a Los Angeles strike over medical malpractice insurance premiums in 1976, only 50% of physicians took part, while Israeli medics striking over pay in 1983 set up their own temporary aid stations outside hospitals to provide emergency care for a fee.

In most cases, only elective treatment stopped and since all surgery comes with a mortality risk, it was these deaths which ceased when doctors withdrew their labour.

Total population mortality in Los Angeles fell from 21 deaths per 100,000 in week one of the doctors’ strike to 14 per 100,000 by week seven – lower than the five-year average.

This is cold comfort at a time when elective waiting lists have already ballooned, however.

Governments and NHS workers look set on a collision course with no easy answers.

Public sector pay rises - who decides and how?

Doctors, nurses and teachers are all threatening to strike as their pay goes up but they say that is not enough as it is below inflation, which has recently soared.


Alix Culbertson
Political reporter @alixculbertson
Tuesday 19 July 2022


Public sector workers including nurses, teachers and doctors have all had pay rises announced.

They have received increases of between 4.5% and 9.3% but unions say most of the pay rises are not enough as they are less than half the current level of RPI inflation.

As those in the public sector receive taxpayers' money, the amount they are paid is determined by their overall employer - the government.

However, there is a lengthy process to determine what their pay should be before ministers ever see a number.

How are public sector pay rises determined?


Pay review bodies


Independent pay review bodies play an integral role in informing the government's final decision on how about 45% of the public sector gets paid - including teachers, nurses, doctors, police officers and members of the armed forces.

They are made up of experts in their field and their appointments are made on merit, not political affiliation.

The process begins when the secretary of state for the relevant area requests recommendations on employee pay from the pay review bodies.

They will set a timeline and parameters such as asking the bodies to consider issues such as affordability, retention, recruitment and the state of the entire labour market.

Departments' spending on pay is limited by the amount of funding they receive from the Treasury.

Read more: Doctors demand 30% pay rise as some medics say they may have to go on strike

NHS doctors and nurses will be included in the pay changes

A range of sources, such as trade unions and their members, as well as employers then submit evidence to the pay review bodies, who will usually visit staff from their sector to determine concerns and opinions.

The government then also submits its formal pay offer at this stage for all levels of staff affected.

After receiving all the evidence from the relevant groups, the pay review bodies then recommend what the level of pay should be.

What happens after the recommendations are made?


The government chooses when it will respond to and publish the reports made by the pay review bodies.

Secretaries of state usually respond to the recommendations by issuing a written ministerial statement in parliament.

On the whole, the recommendations are accepted by secretaries of state, but there have been times when they have overridden the recommendations.

Sectors can disagree with the pay changes and can strike over the decision but the government has the ultimate say.

The latest pay rises will likely be implemented in the autumn but could be backdated to the start of April, when the financial year started.

Are there pay review bodies for all public sector jobs?


No.

Civil servants not in the senior civil service have their pay set by individual departments, according to guidance issued by the Cabinet Office and the Treasury.

Local government staff (not teachers) have their pay determined by their employers and trade unions.

Devolved governments - Northern Ireland, Scotland and Wales - set their own pay policy for public bodies under their control.


Teachers and doctors in UK threaten wage strike after 4.5 percent pay rise

TEACHERS and doctors have threatened fresh strike action after being offered a pay rise of at least 4.5 percent.
NHS staff protest in London in September 2020 (Image: Getty)

Police officers were also handed a £1,900 boost in what the Government says are the highest public sector pay rises in 20 years. But unions say the increases are a “kick in the teeth” as they are a real-terms pay cut due to high inflation, and warn of a wave of industrial action in the autumn.

Following a public sector pay review, more than a million nurses, paramedics, midwives, porters and cleaners will get a rise of at least £1,400, with the lowest earners receiving up to 9.3 percent backdated to April, the Department for Health said.

Dentists and doctors will get 4.5 percent while the average basic pay for nurses will go up from £35,600 to £37,000. Newly qualified nurses will get 5.5 percent taking their pay to £27,055. On Monday Health Secretary Steve Barclay said of the rise: “Very high inflation-driven settlements would have a worse impact on pay packets in the long run than proportionate and balanced increases now, and it is welcome the pay review bodies agree with this approach.”

But Danny Mortimer, chief executive of NHS Employers, said while they were pleased the pay rise for NHS staff was above the original three percent, it still places NHS and public health leaders in the “impossible position of having to choose which services they will cut back on in order to fund the additional rise”.

Meanwhile, the starting salaries for teachers outside London will rise by 8.9 percent to £28,000.

Teachers who have been in the profession for more than five years will get a five percent increase from September.

Education Secretary James Cleverly said: “We are delivering significant pay increases for all teachers despite the economic challenges, giving teachers the ­biggest pay rise in a generation.”

The £1,900 across-the-board pay hike for police officers amounts to an average five percent. Those on the lowest pay are ­getting a rise of up to 8.8 percent. The highest paid will receive between 0.6 percent and 1.8 percent and the minimum starting salary for a police constable degree apprentice will increase to £23,556.

Home Secretary Priti Patel said: “It is right that we recognise the extraordinary work of our officers who day in, day out, work tirelessly to keep our streets, communities and country safe.”

All the rises were recommended by independent public sector pay review bodies, who take evidence and talk to those in the industry.

Their recommendations were all accepted in full by the different government departments, who said the increases recognise the contribution of key workers while balancing the need to protect taxpayers, manage public spending and not drive up inflation.

But union bosses were furious at what they call “a massive national pay cut”.

Unite general secretary Sharon Graham said: “The Government promised rewards for the dedication of the public sector workforce during the pandemic.

“What they have delivered instead, in real terms, is a kick in the teeth.

“We expected the inevitable betrayal but the scale of it is an affront.”

Both the NASUWT and NEU teaching unions said the proposed increase of five percent for more experienced staff is too low. The NEU has said it will now consult its members ­
on whether to take strike action in the autumn.

Kevin Courtney, the joint general secretary, said the five percent increase would mean “yet another huge cut” to the real value of pay against inflation.

And Geoff Barton, general secretary of the Association of School and College Leaders, said the proposed increase is a “real-terms pay cut which will worsen teacher shortages”, with no additional money for schools to fund the rise.

“It is a double whammy that lets down the teaching profession and the pupils in our schools,” he said.

 Minnesota
Nearly 1.2 million apply for 'hero pay'

Brian Bakst
St. Paul
July 22, 2022 5

Nurse Andrew Dennis (left) works a shift Wednesday, Dec. 8 inside the intensive care unit at the St. Cloud Hospital. The Major is part of a 22-member emergency response team from the Department of Defense assisting the staff at the St. Cloud Hospital which has been overwhelmed with COVID-19 cases.

Paul Middlestaedt for MPR News | 2021

Almost twice as many people have applied for pandemic hero bonuses as Minnesota officials once expected would qualify.

As the deadline ran out Friday afternoon nearly 1.2 million applications were submitted— 1,199,512 to be exact— according to the Minnesota Department of Labor and Industry.

The state set aside $500 million in frontline worker pay available to people in more than a dozen job fields – from health care workers to custodians.

That means if everyone who applied ended up getting a bonus they'd get about $400 each. But officials say it's likely that not everyone who applied will be eligible after verification steps are completed.

The bonus checks will be equal in size once the pool of recipients is ultimately determined.

Before the application window opened in June, state officials predicted about 667,000 people would get a check.

Those whose applications are denied will have a chance to appeal.

Putin ‘spits in face’ of United Nations by firing missiles at Odesa

Russian missiles strike the port city a day after deal to export grain from there was signed


Firefighters work at a site of a Russian missile strike in a sea port of Odesa, as Russia's attack on Ukraine continues. Picture by Reuters

James Kilner
July 24 2022 

Vladimir Putin has “spat in the face” of the UN by firing missiles at Odesa just a day after the Kremlin signed a deal to allow grain exports from the port, Ukrainian officials said yesterday.

Kalibr cruise missiles were fired from warships in the Black Sea at infrastructure used to store grain and load it onto cargo ships, according to the Ukrainian air force.

Video footage showed a fire at the port but there were conflicting reports over whether the two missiles had hit a grain storage facility in the mid-morning attack. There were no casualties.

Another video posted online showed sunbathers on a beach near Odesa watching the city’s missile defence system destroy several other Russian rockets in the sky.

“Here is the grain corridor. These scumbags sign contracts with one hand and direct missiles with the other,” said Oleksiy Goncharenko, a Ukrainian MP.

Russia has denied the attacks and said it only fires missiles at military facilities in Odesa.

The city is home to the largest port in Ukraine and is the main export terminal for grain. It was expected to reopen soon as part of a grain export deal signed with Russia in Istanbul on Friday.

But Volodymyr Zelensky said the strike showed Moscow would renege on the agreement.

“This proves only one thing: no matter what Russia says and promises, it will find ways not to implement it,” the Ukrainian president said.

Oleg Nikolenko, his foreign ministry spokesman, said the attack was “Putin’s spit in the face of UN secretary general Antonio Guterres and Turkish president Recep Tayyip Erdogan, who made enormous efforts to reach the agreement”.

He added: “If the reached agreement is not fulfilled, Russia will bear full responsibility for deepening the global food crisis.”

Ukrainian officials said they were continuing to work on restarting exports despite the strikes.

Mr Guterres “unequivocally condemned” the attacks, which could potentially derail grain reaching vulnerable countries in Africa where millions of people are reliant on it as a major part of their diet.

“These products are desperately needed to address the global food crisis and ease the suffering of millions of people in need around the globe,” the UN said in a statement.

Bridget Brink, the US ambassador to Kyiv, called the strike “outrageous”, adding: “The Kremlin continues to weaponise food. Russia must be held to account.” Mr Guterres had described the deal as a “beacon on the Black Sea”. UN officials had said that grain shipments from the three reopened Ukrainian ports would hit pre-war levels of 5 million tonnes per month within a few weeks.

Grain exports have triggered major rows between Ukraine and Russia with Kyiv accusing the Kremlin of stealing its grain to sell illegally on the black market through Syria.

Moscow has denied responsibility for grain shortages around the world and rising prices. It has blamed Western sanctions for slowing fertiliser imports and Ukraine for mining its own Black Sea waters. On a trip to Tehran last week, Mr Putin had discussed grain shipments with Mr Erdogan.

Elsewhere in Ukraine, Russian missiles killed three people yesterday in the Kirovograd region of central Ukraine, hundreds of miles behind the frontlines. Missiles also pounded the city of Mykolaiv, which has been targeted by Russia for weeks.

Officials in Kharkiv, Ukraine’s second-largest city, also reported several missile strikes on the city centre.


Telegraph Media Group Limited [2022]

QUOTES-Reactions to Russia's strike on Ukraine's Odesa port

KYIV, July 23 (Reuters) - A Russian strike on Ukraine's Odesa port on Saturday has threatened a deal to aid grain exports and ease a global food crisis.

Following is global reaction:

UNITED NATIONS SPOKESPERSON

"The Secretary-General (Antonio Guterres) unequivocally condemns reported strikes today in the Ukrainian port of Odesa. Yesterday, all parties made clear commitments on the global stage to ensure the safe movement of Ukrainian grain and related products to global markets. These products are desperately needed to address the global food crisis and ease the suffering of millions of people in need around the globe."

UKRAINIAN PRESIDENT VOLODYMYR ZELENSKIY

"This proves only one thing: no matter what Russia says and promises, it will find ways not to implement it (the grain deal)."

RUSSIA

A Russian defence ministry statement on Saturday outlining progress in the war did not mention any strike in Odesa. The ministry did not immediately reply to a Reuters request for comment.

However, Foreign Ministry spokeswoman Maria Zakharova reposted the U.N. condemnation and said: "It is awful that UN Secretary General Antonio Gutteres does not 'unequivocally' condemn also the Kyiv regime's killing of children in Donbas."

TURKISH DEFENCE MINISTER HULUSI AKAR

"They (Ukrainian officials) stated that one of the missile attacks hit one of the silos there, and the other one fell in an area close to the silo, but there was no problem in the loading capacity and capability of the docks, which is important, and that the activities there can continue.

"The Russians told us that they had absolutely nothing to do with this attack, and that they were examining the issue very closely and in detail. The fact that such an incident took place right after the agreement we made yesterday regarding the grain shipment really worried us."

UKRAINIAN INFRASTRUCTURE MINISTER OLEKSANDR KUBRAKOV

"We continue technical preparations for the launch of exports of agricultural products from our ports."

GERMAN FOREIGN MINISTER ANNALENA BAERBOCK

"The cowardly missile attacks on the port of Odesa show that the Russian leadership's signature counts for little at the moment."

U.S. AMBASSADOR TO KYIV BRIDGET BRINK

"Outrageous. Russia strikes the port city of Odesa less than 24 hours after signing an agreement to allow shipments of agricultural exports. The Kremlin continues to weaponize food. Russia must be held to account."

EU FOREIGN POLICY CHIEF JOSEP BORRELL

"Striking a target crucial for grain export a day after the signature of Istanbul agreements is particularly reprehensible and again demonstrates Russia's total disregard for international law and commitments."

UK FOREIGN SECRETARY LIZ TRUSS

"It is absolutely appalling that only a day after striking this deal, (Russian President) Vladimir Putin has launched a completely unwarranted attack on Odesa.

"It shows that not a word he says can be trusted and we need to urgently work with our international partners to find a better way of getting the grain out of Ukraine that doesn't involve Russia and their broken promises."

UKRAINE FOREIGN MINISTRY SPOKESPERSON OLEG NIKOLENKO

"The Russian missile is Vladimir Putin's spit in the face of UN Secretary General Antonio Guterres and Turkish President Recep Erdogan, who went to great lengths to reach an agreement and to whom Ukraine is grateful."

HEAD OF UKRAINIAN PRESIDENT'S OFFICE ANDRIY YERMAK

"The Russians are systematically creating a food crisis, doing everything to make people suffer. Famine terror continues. The world must act. The best food safety guarantees are twofold: effective sanctions against Russia and more weapons for Ukraine."

MAKSYM MARCHENKO, GOVERNOR OF ODESA REGION

"Unfortunately there are wounded people. The port's infrastructure was damaged."

(Reporting by Reuters bureaux; Compiled by Andrew Cawthorne; Editing by Frances Kerry)

Centaurus: what we know about the new COVID variant and why there’s no cause for alarm










Published: July 22, 2022 
Ben Krishna
THE CONVERSATION

A new COVID variant has recently been detected in several countries including the UK, US, India, Australia and Germany.

Called BA.2.75, it’s a subvariant of omicron. You might have also heard it called “Centaurus”, the name of a constellation and given to BA.2.75 by a Twitter user.

The World Health Organization has classified BA.2.75 as a variant of interest, rather than a variant of concern. This means it’s being monitored but there’s not yet evidence it will cause problems.

The numbers of BA.2.75 infections are still relatively low. Most infections in the UK remain driven by the omicron subvariants BA.4 and BA.5. BA.5 in particular is similarly dominant in other countries where BA.2.75 has been detected.

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However, BA.2.75 is becoming more common in India (where it was first detected, back in May), suggesting it has advantages relative to current circulating variants. Some have noted that BA.2.75 is spreading in regions of India where it doesn’t have to compete with BA.5, but rather with the variant it evolved from, BA.2.

That said, some data from India indicates that BA.2.75 may have already peaked. And importantly, there hasn’t been a big increase in hospitalisations or deaths in India from BA.2.75.

Given this, BA.2.75 has quickly gained an additional nickname: a “scariant”.
Why are we still seeing new variants?

As most of the global population has now either been vaccinated, infected, or both, variants which can infect people despite their immunity will have an advantage. So SARS-CoV-2 (the virus that causes COVID) is constantly evolving to gain this advantage.

New variants which have mutations that evade our immunity will replicate and spread, leading to waves of infections. We’ve seen this most recently with BA.4 and BA.5.

The memory immune system recognises infections based on molecular structures of viruses and other pathogens. Mutations change the molecular structure of each SARS-CoV-2 variant slightly, making it more difficult for our immune system to recognise and respond to the virus. This is often called “immune evasion”.

Read more: SARS-CoV-2 mutations: why the virus might still have some tricks to pull

The concern around BA.2.75 is that is has picked up a number of mutations, which might indicate that this variant can evade immunity. But there’s no good evidence at this stage that BA.2.75 can evade the immune system in a significant way.

Most of BA.2.75 is structurally the same as omicron and the original Wuhan variant. Although BA.2.75 has picked up a few mutations, it isn’t fundamentally a different virus.

The memory immune system will still act against BA.2.75, which is what we’ve seen with omicron. This immunity might not be enough to stop reinfection, but should reduce the severity of a BA.2.75 infection.

While there are concerns BA.2.75 could spread more quickly than other variants, we don’t have any clear evidence on this yet. It seems to have shown an increase which has levelled off or even dropped relative to a few weeks ago. If this is the case there’s a chance it might even fizzle out in another few weeks.

But, if BA.2.75 does have some immune evasion properties, it could cause another wave through the UK and elsewhere. Still, this would likely spike and then fizzle out like alpha, delta and omicron BA.1.
BA.2.75 isn’t likely to be too much of a threat. Drazen Zigic/Shutterstock

Improving vaccines could be our best shot

Thanks to vaccination, if we did face a BA.2.75 wave, we wouldn’t expect the level of deaths and hospitalisations seen earlier in the pandemic. But we know large numbers of cases can still cause significant disruption. And importantly, the constant wave of new variants is still a deadly threat to people who are vulnerable. So how do we overcome this?

One solution could be universal COVID vaccines, which would work against any COVID variants. The aim of a universal vaccine is to induce immunity against a very wide range of molecular structures. It’s akin to fishing with a wider net, making it harder for the fish to swim out of the way.

A pan-coronavirus vaccine is a similar concept but would likely try to induce immunity against the molecular structures common to all coronaviruses. As well providing immunity against new SARS-CoV-2 variants, a pan-coronavirus vaccine might also confer immunity against the next coronavirus pandemic. Some of these vaccines look set to move into clinical trials in the next few years.

A second solution may be to produce vaccines which induce better immunity in the respiratory system. These largely involve vaccines given through your nose, training the immune system to make more antibodies in the mucus of the nose and throat.

This type of immunity might help stop SARS-CoV-2 infecting and replicating at the point of entry into our cells, which could slow down the rate at which new variants have the opportunity to emerge. At least 12 of these intranasal vaccines are in clinical trials.

Author
Ben Krishna
Postdoctoral Researcher, Immunology and Virology, University of Cambridge
Disclosure statement

UPDATED

The effects of Long COVID


Deutsches Ärzteblatt International publishes themed issue on Long COVID

Peer-Reviewed Publication

DEUTSCHES AERZTEBLATT INTERNATIONAL

COLOGNE: Three articles and an accompanying editorial provide information on the effects of Long COVID in the Deutsches Ärzteblatt International’s volume 10, a themed issue on the subject:

Christian Förster and coauthors report data on persistent symptoms after COVID-19 in their original article (Dtsch Arztebl Int 2022; 119: 167–74). In a population-based cohort study they collected data on the prevalence and on risk factors. The background for this study is the observation that after recovering from infection with COVID-19, many people complain of long-term symptoms. To date, the results of epidemiological studies of this observation vary enormously. The authors used a questionnaire to collect in three rural districts data on symptoms and clinical characteristics after COVID-19, with the focus on symptoms after 12 weeks. They evaluated data from 1450 patients. The prevalence of Post-COVID-19 was 72.6% in people admitted to hospital and 46.2% in those not admitted to hospital. The most common long-term symptoms were fatigue, physical exhaustion, difficulty concentrating, and loss of smell or taste. The patients with Post-COVID-19 perceived their quality of life as notably reduced. The strongest risk factors for Post-COVID-19 were female sex, overall severity of comorbidities, and severity of acute COVID-19. According to the researchers, non-hospitalized patients also often experienced continuing symptoms. In their view, the heterogeneity of the symptoms requires a multidisciplinary, stepwise approach to care. Identifying at-risk patients, they say, is crucial.

Another article on the prevalence of persistent symptoms after COVID-19 is presented by Korbinian Lackermair and colleagues (Dtsch Arztebl Int 2022; 119: 175–6). The authors undertook a cross sectional study of 896 patients treated exclusively on an outpatient basis. In addition to determining the prevalence, the researchers investigated the question whether less severe infection correspondingly causes fewer persistent symptoms. They collected their data from structured telephone interviews that were based on a standardized questionnaire. In the study period from March 2020 to February 2021, 1673 patients at Dachau medical center tested positive for COVID-19. For 896 patients, the complete follow-up questionnaire was available. The mean follow-up period was 6.9 months, patients’ mean age was 41.7 years. In about half of patients, comorbidities were present. 34% of patients reported persistent symptoms. The authors found that in addition to non-specific symptoms, such as fatigue or headache, typical COVID-19 symptoms—such as loss of smell or taste, or dyspnea—also often persisted. Patients with persistent symptoms were significantly older, more of them were women, and the acute phase was associated with more symptoms.

The case–control study of postacute sequelae of SARS-CoV-2 infection reported by Mandy Schulz and coauthors also studied patients treated on an outpatient basis (Dtsch Arztebl Int 2022; 119: 177– 8). The authors aimed to characterize patients with regard to risk factors and use of healthcare services. To this end they used nationwide billing data from statutory health insurance (SHI) providers. They included patients who in the second quarter of 2021 had been coded as ICD-10 U09.9!. This was the case for 160,663 patients. The control group was a random sample of all patients treated in the second quarter of 2021 (n=321,326), which matched in terms of age, sex, and place of residence, and for whom neither a post-COVID code had been issued in 2021 nor confirmed COVID-19 infection (ICD-Code U 07.1!) documented in 2020 and 2021. The group of cases included more women and middle-aged patients than the control group as well as a higher proportion of patients who had been treated by SHI-authorized physicians as early as 2020. Patients with COVID-19 accounted for almost double the number of treatment cases compared to the control group. At least one of the post-COVID-symptoms under study occurred in 61% of the cases and in 33% of the controls. Patients with comorbidities, such as back pain, obesity, adjustment disorders, and somatoform disorders had a greater age-dependent risk for post-COVID-19. In the Post-COVID-19 group, SHI-accredited services were more commonly sought, especially GP consultations, than in the control group.

Tobias Welte in an accompanying editorial (Dtsch Arztebl Int 2022; 119: 165–6) concludes that the post-COVID syndrome throws up more questions than it provides answers. He distinguishes between three groups of patients in post-COVID symptoms: patients who had been treated as inpatients, and partly in intensive care, for COVID-19; patients with many different symptoms who, however, were not severely impaired in their everyday lives; and patients who cannot manage their everyday lives independently because of massive exhaustion and inadequate resilience. The second group included the greatest number of patients. They presented predominantly with weariness and difficulty concentrating, together with the feeling of a lack of stamina. In Welte’s opinion, the challenge in treating these patients lies in differentiating between COVID-19 triggered medical impairments and pandemic-related psychosocial changes. The sequelae of COVID-19 can, he concludes, only be alleviated by reducing the number of infections and by changing attitudes. The pathogen is not likely to disappear in the foreseeable future, and SARS-CoV-2–related diseases will become part of our everyday lives, in the same way as other infectious diseases. For this reason, the options of prevention and therapies should be used, so as to learn to live with COVID-19.

https://www.aerzteblatt.de/int/archive/issue?heftid=6821

Welte T: Post-COVID syndrome—more questions than answers. Dtsch Arztebl Int 2022; 119: 165–6. DOI: 10.3238/arztebl.m2022.0154

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Females far likelier to suffer with Long COVID, a new review of studies shows, underscoring a critical need for sex-disaggregated research

The odds of females developing Long COVID syndrome is 22% higher than males, researchers find

Peer-Reviewed Publication

TAYLOR & FRANCIS GROUP

A new study published today in the peer-reviewed journal Current Medical Research and Opinion, reveals that females are “significantly” more likely to suffer from Long COVID than males and will experience substantially different symptoms.

Long COVID is a syndrome in which complications persist more than four weeks after the initial infection of COVID-19, sometimes for many months. 

Researchers from the Johnson & Johnson Office of the Chief Medical Officer Health of Women Team, who carried out the analysis of data from around 1.3 million patients, observed females with Long COVID are presenting with a variety of symptoms including ear, nose, and throat issues; mood, neurological, skin, gastrointestinal and rheumatological disorders; as well as fatigue.

Male patients, however, were more likely to experience endocrine disorders such as diabetes and kidney disorders.

“Knowledge about fundamental sex differences underpinning the clinical manifestations, disease progression, and health outcomes of COVID-19 is crucial for the identification and rational design of effective therapies and public health interventions that are inclusive of and sensitive to the potential differential treatment needs of both sexes,” the authors explain.

“Differences in immune system function between females and males could be an important driver of sex differences in Long COVID syndrome. Females mount more rapid and robust innate and adaptive immune responses, which can protect them from initial infection and severity. However, this same difference can render females more vulnerable to prolonged autoimmune-related diseases.”

As part of the review, researchers restricted their search of academic papers to those published between December 2019–August 2020 for COVID-19 and to January 2020–June 2021 for Long COVID syndrome. The total sample size spanning articles reviewed amounted to 1,393,355 unique individuals.

While the number of participants sounds large, only 35 of the 640,634 total articles in the literature provided sex disaggregated data in sufficient details about symptoms and sequalae of COVID-19 disease to understand how females and males experience the disease differently.

When looking at the early onset of COVID-19, findings show that female patients were far more likely to experience mood disorders such as depression, ear, nose, and throat symptoms, musculoskeletal pain, and respiratory symptoms. Male patients, on the other hand, were more likely to suffer from renal disorders—those that affect the kidneys.

The authors note that this synthesis of the available literature is among the few to break down the specific health conditions that occur as a result of COVID-related illness by sex. Plenty of studies have examined sex differences in hospitalization, ICU admission, ventilation support, and mortality. But the research on the specific conditions that are caused by the virus, and its long-term damage to the body, have been understudied when it comes to sex.

“Sex differences in outcomes have been reported during previous coronavirus outbreaks,” authors add. “Therefore, differences in outcomes between females and males infected with SARS-CoV-2 could have been anticipated. Unfortunately, most studies did not evaluate or report granular data by sex, which limited sex-specific clinical insights that may be impacting treatment.” Ideally, sex disaggregated data should be made available even if it was not the researcher’s primary objective, so other interested researchers can use the data to explore important differences between the sexes.

The paper also notes complicating factors worthy of additional study. Notably, women may be at greater risk of exposure to the virus in certain professions, such as nursing and education. Further, “there may be disparities in access to care based on gender that could affect the natural history of the disease, leading to more complications and sequela.”

The latter serves as a rallying cry: availability of sex disaggregated data and intentional analysis is imperative if we are to ensure that disparate outcomes in disease course are addressed.  No research is complete unless the data is made available to people who want to answer the question: does sex and gender matter?

UCLA launches effort to expand its COVID test to detect other emerging viruses


New effort seeks to adapt SwabSeq technology to detect all novel pathogens

Grant and Award Announcement

UNIVERSITY OF CALIFORNIA - LOS ANGELES HEALTH SCIENCES

UCLA Health is joining a new effort to increase the ability to quickly respond to emerging pathogens by creating the capability to detect all existing and new respiratory RNA viruses in a single test. The project is being funded by Biomedical Advanced Research and Development Authority (BARDA)’s Division of Research, Innovation and Ventures (DRIVe), which leverages new authorities given under the 21st Century Cures Act.

DRIVe is funding the UCLA SwabSeq Laboratory to adapt SwabSeq technology to develop scalable sequencing approaches for the detection of novel pathogens. Currently, SwabSeq technology amplifies a portion of the SARS-CoV-2 genome to detect the virus. The new project will extend the SwabSeq technology to develop an “agnostic” test. In this approach, instead of amplifying a specific virus, human RNA is instead depleted in the sample and the remaining RNA is sequenced. This approach has the potential to identify any RNA virus including new and emerging pathogens.

UCLA and others involved in the project will optimize their in-house next generation sequencing capabilities for commercial clinical use, including by lowering the sample-to-result time to under 24 hours, reducing interference from host RNA, and performing analytical validation of the platform using both contrived and clinical respiratory samples.

Next generation sequencing, which exists in other areas like oncology and certain genetic disorders, is sorely needed for infectious diseases due to health security threats. The goal is to create an agnostic test to detect any respiratory RNA virus, including new and emerging viruses that can be implemented rapidly and without the need for additional regulatory approvals in future pandemic situations.

In a viral outbreak or pandemic, having agnostic tests that can detect any respiratory RNA virus and can be implemented rapidly without the need for additional regulatory approvals is crucial. Next generation sequencing technology can detect and analyze viral genomes from any existing or emerging viruses in an unbiased manner compared to targeted polymerase chain reaction (PCR) and antigen assays. PCR and antigen assays require a significant effort to develop, verify, validate, as well as earn regulatory approval.

In pandemic situations, next-generation sequencing assays could provide the capability for agnostic detection ability, especially with emerging respiratory pathogens and can be used on day one with appropriate regulatory approval. These tests also provide information crucial to timely and actionable patient care.

UCLA’s SwabSeq Laboratory is a CLIA-certified laboratory created in April 2020 in response to the COVID-19 pandemic. Genomic and computational scientists at UCLA developed the new technology based on next-generation sequencing—the SwabSeq COVID-19 Diagnostic Platform—which obtained FDA EUA approval and was deployed within 6 months. In 2021, the UCLA SwabSeq Laboratory was awarded a contract from NIH's Rapid Acceleration of Diagnostics (RADx) program to leverage automation to expand the lab’s capacity. Since deployment, the UCLA SwabSeq Laboratory has processed over 1.5 million COVID-19 tests, providing high-throughput low-cost testing to multiple universities, local schools, and other partners. The UCLA SwabSeq Laboratory is housed in the UCLA Department of Computational Medicine.