Friday, January 27, 2023

Gambling advertising restrictions could reduce harm

Gambling advertising restriction could reduce related harms, especially on vulnerable individuals, a new review of the evidence has shown

Peer-Reviewed Publication

UNIVERSITY OF SHEFFIELD

Gambling advertising restrictions could reduce harm 

  • Researchers from the University of Sheffield and Glasgow explored the relationship between exposure to gambling advertising and attitudes, intentions and behaviours which may be associated with an increased risk of gambling related harms
  • Evidence showed the impact on children, young people and those already at risk from current gambling activity are more likely to be influenced by gambling advertising
  • Gambling-related harms represent a significant potential driver of health inequalities, because those already experiencing financial, social and mental health disadvantage are also at increased risk of experiencing gambling-related harm

Gambling advertising restriction could reduce related harms, especially on vulnerable individuals, a new review of the evidence has shown.

Researchers from the University of Sheffield explored the relationship between exposure to gambling advertising and attitudes, intentions and behaviours which may be associated with an increased risk of gambling related harms such as debt, relationship problems, physical and mental health problems and crime.  

The team analysed eight recent reviews in this field which included data from over 70 research papers, using a variety of research methods to investigate the relationship between advertising and gambling. The research in this field consistently found a causal relationship between exposure to adverts for gambling products or brands and greater intentions to gamble and increased gambling activity.

The findings, published in the journal Public Health, found evidence of a dose-response effect; greater advertising exposure increases participation which leads to greater risk of harm. 

There was also evidence for the impact on children and young people, and those already at risk from current gambling activity, with those most vulnerable more likely to be influenced.

Professor Elizabeth Goyder, Professor of Public Health at the University of Sheffield’s School of Health and Related Research, said: “Gambling-related harms represent a significant potential driver of health inequalities, because those already experiencing financial, social and mental health disadvantage are also at increased risk of experiencing gambling-related harm. And those already at risk of harm from their gambling have consistently been shown to be more likely to be prompted to gambling by exposure to advertising.

“The substantial evidence we found in all the recent reviews of evidence in this field supports the use of restriction to reduce exposure to gambling advertising. This is particularly likely to reduce risk of harm to children and young people and adults who are already vulnerable to gambling-related harms. 

“Such restrictions could not only reduce overall harm, but also mitigate the impact of advertising on gambling related inequalities.”  

She added:  “Our study has shown public health harm prevention strategies should ideally include a range of policies which limit exposure to advertising, particularly among children and vulnerable groups.”

The report was funded by City Hall, London, to provide an independent evidence briefing on the evidence base related to the health and inequalities impacts of gambling advertising.

Researchers recognise the evidence base for the study does have limitations as it is largely characterised by surveys and qualitative studies of self-reported exposure, attitudes and behaviour in the general population. 

ENDS

Small study shows promise for antimalarial monoclonal antibody to prevent malaria

University of Maryland School of Medicine researchers found CIS43LS to be safe, well tolerated in human challenge trial

Peer-Reviewed Publication

UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE

BALTIMORE, January 25, 2023—A monoclonal antibody treatment was found to be safe, well tolerated, and effective in protecting against malaria in a small group of healthy volunteers who were exposed to malaria in a challenge study, according to new research published in The Lancet Infectious Diseases by researchers at the University of Maryland School of Medicine (UMSOM).

“The study demonstrates the feasibility of using monoclonal antibody therapies to help prevent malarial infection and holds promise for deployment to places where the disease is endemic,” said Kirsten Lyke, MD, Professor of Medicine and Director of the Malaria Vaccine and Challenge Unit in the Center for Vaccine Development and Global Health (CVD) at UMSOM. “This may allow us to revisit malaria eradication efforts.”

There were 241 million malaria cases and 627,000 deaths reported worldwide in 2020 alone, which is a 12 percent increase from 2019. Public health experts contend new strategies are urgently needed to achieve the United Nation’s sustainable development goal of 90 percent reduction in malaria incidence and mortality by 2030. Scientists have tried for decades to develop a highly effective malaria vaccine without much success.

Monoclonal antibodies represent a promising approach to reduce malaria morbidity and mortality, and they offer a new tool for use in in preventing infection. Highly effective malaria vaccines have so far been elusive since they have not been shown to provide much protection in those who have already been infected with malaria earlier in life, but numerous trials conducted by CVD investigators show promise in this arena as well.

CVD was the first center in the world to develop controlled human malaria infection studies, providing proof of principle that live attenuated malaria vaccines protect against infection. CVD researchers conducted genome-wide studies of antimalarial drug resistance and have tested monoclonal antibodies for treating malaria. This is the first time they have tested an experimental monoclonal antibody in a challenge study in a CVD lab in Baltimore.

The new research describes the final dose selection section of a three-part clinical trial. The monoclonal antibody CIS43LS provided high levels of protection in the first two parts of the trial, in which researchers administered 20 or 40 milligrams per kilogram (mg/kg) of the monoclonal antibody via IV infusions. In the current study, 29 healthy study participants, ages 18 to 50 years – who had no prior malaria infections or vaccinations – received a single dose of CIS43LS in doses of 1, 5, or 10 mg/kg via IV infusions, or by subcutaneous injection (injected just under the skin).

Study participants were bitten by five mosquitoes infected with a Plasmodium falciparum strain of malaria about eight weeks after they were given the monoclonal antibody. A single dose of CIS43LS at 5-10 mg/kg administered subcutaneously or intravenously provided high level protection against a controlled human malaria infection with partial protection achieved at 1 mg/kg administered intravenously. Eight control participants who did not receive the monoclonal antibody all developed malaria. All participants were monitored for 24 weeks.

Immunologic studies suggest a level of protection that might extend to 6 months after administration. Furthermore, administering the monoclonal antibody subcutaneously is an easier means of delivering the dosing and allows for widespread distribution to children and adults in malaria endemic areas.

“While previous research suggests that monoclonal antibodies can be effective against malaria using higher dose IV infusions, this new study finds that the prophylactic treatment can also provide a high-level of protection with just a single injection,” said UMSOM Dean Mark T. Gladwin, MD, Vice President for Medical Affairs, University of Maryland, Baltimore, and the John Z. and Akiko K. Bowers Distinguished Professor. “That’s a potential game changer that could provide a practical way to deploy monoclonal antibody therapies in African countries.”

Adverse events from the monoclonal antibody were mild and included pain or redness at the infusion site, headache, abdominal pain, and hypertension, which resolved within a day. The study authors said additional research is needed to explore whether CIS43LS can be used for long-term protection and to determine optimal dosage in African children. Additionally, future research should assess whether monoclonal antibodies can be safely used to protect pregnant women. Phase 2 clinical trials are underway in Mali and Kenya. The technology of monoclonal antibodies may lend an important tool towards the eradication of human malaria.

Additional coauthors on the newly published research from UMSOM include: Andrea A. Berry, MD, Associate Professor of Pediatrics and Medicine, and others in CVD’s Malaria Research Program.

This research is funded by the National Institute of Allergy and Infectious Diseases, Intramural Research Program, National Institutes of Health, ClinicalTrials.gov registration number NCT04206332.

About the University of Maryland School of Medicine

Now in its third century, the University of Maryland School of Medicine was chartered in 1807 as the first public medical school in the United States. It continues today as one of the fastest growing, top-tier biomedical research enterprises in the world -- with 46 academic departments, centers, institutes, and programs, and a faculty of more than 3,000 physicians, scientists, and allied health professionals, including members of the National Academy of Medicine and the National Academy of Sciences, and a distinguished two-time winner of the Albert E. Lasker Award in Medical Research. With an operating budget of more than $1.3 billion, the School of Medicine works closely in partnership with the University of Maryland Medical Center and Medical System to provide research-intensive, academic, and clinically based care for nearly 2 million patients each year. The School of Medicine has nearly $600 million in extramural funding, with most of its academic departments highly ranked among all medical schools in the nation in research funding. As one of the seven professional schools that make up the University of Maryland, Baltimore campus, the School of Medicine has a total population of nearly 9,000 faculty and staff, including 2,500 students, trainees, residents, and fellows. The combined School of Medicine and Medical System (“University of Maryland Medicine”) has an annual budget of over $6 billion and an economic impact of nearly $20 billion on the state and local community. The School of Medicine, which ranks as the 8th highest among public medical schools in research productivity (according to the Association of American Medical Colleges profile) is an innovator in translational medicine, with 606 active patents and 52 start-up companies. In the latest U.S. News & World Report ranking of the Best Medical Schools, published in 2021, the UM School of Medicine is ranked #9 among the 92 public medical schools in the U.S., and in the top 15 percent (#27) of all 192 public and private U.S. medical schools. The School of Medicine works locally, nationally, and globally, with research and treatment facilities in 36 countries around the world. Visit medschool.umaryland.edu

About the Center for Vaccine Development and Global Health

For over 40 years, researchers in the Center for Vaccine Development and Global Health have worked domestically and internationally to develop, test, and deploy vaccines to aid the world’s underserved populations. CVD is an academic enterprise engaged in the full range of infectious disease intervention from basic laboratory research through vaccine development, pre-clinical and clinical evaluation, large-scale pre-licensure field studies, and post-licensure assessments. CVD has worked to eliminate vaccine-preventable diseases. CVD has created and tested vaccines against cholera, typhoid fever, paratyphoid fever, non-typhoidal Salmonella disease, shigellosis (bacillary dysentery), Escherichia coli diarrhea, nosocomial pathogens, tularemia, influenza, malaria, and other infectious diseases. CVD’s research covers the broader goal of improving global health by conducting innovative, leading research in Baltimore and around the world. CVD researchers are developing new and improved ways to diagnose, prevent, treat, control, and eliminate diseases of global impact. Currently, these diseases include typhoid, Shigella, E. coli diarrhea, malaria, and other vaccine-preventable infectious diseases. CVD researchers have been involved in critical vaccine development for emerging pathogens such as Ebola and Zika. In addition, CVD’s work focuses on the ever-growing challenge of antimicrobial research.

Holocaust education is expanding in Africa, the Arab World, and Eastern Europe

On the eve of International Holocaust Remembrance Day 2023 The Center for the Study of Contemporary European Jewry at Tel Aviv University presents a new annual report:

Reports and Proceedings

TEL-AVIV UNIVERSITY

Findings for 2022 include:

  • Significant new initiatives in several Eastern-European countries for teaching the history of the Holocaust and fighting antisemitism
  • Cyprus has become a leader in the fight against antisemitism and racism
  • Growing interest in Holocaust education in several African countries
  • Growing recognition of the Holocaust in the Arab world, alongside renewed cultivation of Jewish heritage
  • All this – alongside a wave of educational and legislative initiatives in Western Europe, America, and Australia
  • The Report aims to express appreciation for positive initiatives, encourage other similar activities, and propose ways for further improvement.

On the eve of International Holocaust Remembrance Day 2023, The Center for the Study of Contemporary European Jewry at Tel Aviv University published its annual report entitled 'For a Righteous Cause', focusing on initiatives of governments and citizens around the world to preserve Jewish heritage, teach about the Holocaust, and combat antisemitism and racism in general. The report aims to express appreciation for inspiring initiatives, encourage other similar activities, and propose ways for further improvement.

 

Link to the  full report: 

https://www.tau.ac.il/sites/default/files/media_server/General/sp/For%20a%20Righteous%20Cause%202023.pdf

 

The findings presented in the Report indicate that recognizing the Holocaust and teaching lessons derived from it have recently expanded, even in countries where Holocaust education was uncommon, including in Africa and the Arab World. Alongside this positive trend, many educational, social, and legal initiatives for combating Holocaust denial and antisemitism have been advanced in Western Europe, America, and Australia, indicating broad recognition of the problem and its severity.

 

Prof. Uriya Shavit, Head of the Center: "Regretfully, it must be admitted that despite global support for the fight against antisemitism, being a Jew has become less safe almost everywhere in the world. But giving up the struggle is not the solution. We must learn systematically, in a comparative manner, what has been done and what can be improved."

 

Prof. Shavit added that "While our purpose was to highlight positive initiatives for combating antisemitism all over the world, we also noted at the beginning of the Report that his fight must not become the only identity-definer of Jewish intellectuals and organizations, that the Jewish moral compass must not be limited to this issue alone, and that the study of Jewish history should not focus solely on the Holocaust. Israel cannot express reservations about European political parties with roots in fascism and expect to find a different attitude in Europe toward Israeli parties with fascist roots."

 

The Report was authored by eight experts from different disciplines, including: Dr. Carl Yonker, Project Manager and Senior Researcher at the Center (Around the World: Government Initiatives, Legal Developments; the Example of Cyprus); the Center's Founder, Prof. Dina Porat (Holocaust Remembrance in Africa); Dr. Ofir Winter (The Arab World); Adv. Talia Naamat (Around the World: Government Initiatives, Legal Developments); and researcher Fabian Spengler (Football: The Test Case of Borussia Dortmund in Germany).

 

A selection of highlights from the Report:

Holocaust education is spreading beyond Western Europe and America to countries in Africa and the Arab World.

The Report’s findings indicate that recognition and teaching of the Holocaust have spread - even to countries where it was previously uncommon.

 

The Report includes an extensive discussion about Cyprus, presenting it as a model to be emulated: even though no antisemitic incidents have been recorded in the country in recent years, its government has emphasized teaching the history of the Holocaust and the lessons derived from it in the education system, in law enforcement organizations, and in sports clubs. This approach is based on a proactive view, an overall commitment to combating racism and xenophobia, and an understanding that learning about the Holocaust and fighting antisemitism is critical for a society that aims to strengthen its democratic and liberal values.

 

The Report analyzes the emerging interest in Jewish history and the Holocaust in several African countries, which see a resemblance between the tragedies experienced by the Jewish people and crimes against humanity perpetrated on the African continent. This sentiment is expressed, for example, in the Genocide Memorial National Museum in Rwanda, which commemorates the genocide of the country's Tutsi minority that occurred four decades after the Holocaust while the world looked on in silence.

 

According to the Report, an encouraging trend was observed this year in several Arab countries, with rising recognition of the history of antisemitism and the crimes of the Nazis. For example, in January 2022, Egypt took part in a session of the UN General Assembly that adopted a resolution condemning Holocaust denial. The Egyptian Ambassador to the UN conveyed the Arab consensus on the resolution.

 

This positive trend reflects a significant turnaround in Arab discourse on Jewish history. This was displayed in quite a few new initiatives, some in the literary sphere, promoting the preservation of Jewish heritage in several Arab countries, including Saudi Arabia, Egypt, and Morocco. These projects are described extensively in the Report.

 

Significant positive developments were also observed in formerly Communist countries. In December 2021, the Elie Wiesel National Institute for the Study of the Holocaust in Romania launched the project “Stories from the Holocaust - Local Histories.” This initiative aimed to enhance the knowledge of Romanians about the history of their communities from the perspective of Jews and Roma persecuted during the Holocaust. In 2022 the project included street exhibitions featuring the life stories of Jews and Roma and their tribulations during this dark period.

 

In November 2022, the Bulgarian Foreign Ministry organized an international conference on combating antisemitism and preserving Jewish heritage.

 

A significant step forward in combating antisemitism was also recorded in Ukraine. In February 2022, just a week before the fascist Russian invasion, the Ukrainian Parliament approved strict sentencing measures for antisemitic hate crimes: five to eight years in prison for antisemitic violence and a substantial fine for anti-Jewish incitement.

 

A wave of educational and legislative initiatives in Europe, America, and Australia

The Report documents many initiatives introduced over the past year in the Western World for preserving Jewish heritage, teaching about the Holocaust, and combating antisemitism. The initiatives indicate a growing awareness of the dangers posed by antisemitic propaganda on the internet, as well as increasing recognition of the importance of educating younger generations about the Holocaust.

 

Notable initiatives included:

In October 2022, the European Commission marked the first anniversary of the “European Union Strategy on Combating Antisemitism and Fostering Jewish Life (2021-2030)”. Actions during the first year included: combating antisemitism on the internet; the signing of the Vienna Declaration by 11 EU member states and several international organizations which committed to developing a common, standard methodology for recording antisemitic incidents; and launching a project to protect Jewish cemeteries in Moldova, Ukraine, Georgia, Poland, Hungary, Slovakia, and the Czech Republic.

 

Following discussions held in 2022, the European Parliament and European Commission are expected to pass the Digital Services Act, requiring online platforms to remove hate speech, provide information on their use of algorithms, and have clear rules to address complaints related to hate speech.

 

In January 2022, the Austrian Parliament was presented with the first annual implementation report detailing actions to advance the country’s National Strategy to prevent and combat all forms of antisemitism. Actions included: safeguarding Jewish life in the country and ensuring the Jewish community’s future; adoption of the IHRA Working Definition by Austria's top football league, the Bundesliga; holding seminars on antisemitism for police officers; and initiating a declaration against antisemitism at the UN Human Rights Council.

 

In March 2022, the United States Senate appointed the country's first special ambassador for monitoring and combating antisemitism, historian Prof. Deborah Lipstadt. In the summer, Lipstadt traveled to Israel, Saudi Arabia, and the United Arab Emirates. In March, President Biden signed the 2022 federal government funding package of US$2M to implement the Never Again Education Act. These funds will be used for training teachers by the US Holocaust Memorial Museum, as well as special activities for monitoring and combating global antisemitism. New York Governor Kathy Hochul signed three bills to ensure that schools in the state provide high-quality Holocaust education, that museums acknowledge art stolen by the Nazi regime, and that Holocaust survivors receive their reparation payments from Germany in full. Several states in the US, including New York, Iowa, New Mexico, and Arizona, adopted the IHRA definition of antisemitism.

 

In April, Canada introduced a federal bill that defines punishments for denying, condoning, or downplaying the Holocaust, and earmarks $70M for funding Jewish community initiatives. The city of Toronto launched a new public education campaign to raise awareness about antisemitism under the title “Toronto for All”. The campaign calls upon local citizens to become educated about the Jewish community and antisemitism, create inclusive spaces, and make their voices heard when they witness acts of bias and hate - offering support to victims, and reporting hate crimes to the authorities. The Canadian Provinces British Columbia and Alberta adopted the IHRA definition of antisemitism.

 

In July, the Organization of American States (OAS), in cooperation with the American Jewish Committee (AJC), co-published a Spanish-language handbook entitled “Handbook for the Practical Use of the IHRA Working Definition of Antisemitism". Guatemala and Colombia adopted the IHRA definition of antisemitism, joining the United States, Canada, and Argentina in the pledge to confront antisemitism throughout the Western Hemisphere.

 

Several positive initiatives were also seen in Australia. New South Wales, Victoria, and South Australia adopted the IHRA definition of antisemitism. Victoria and NSW passed legislation banning public displays of Nazi symbols, specifically the swastika, with a maximum punishment of a year in jail and/or a substantial fine. Queensland and Tasmania also introduced legislation to ban Nazi symbols.

 

Borussia Dortmund, the major German football club, gets off the bench

The Report presents a detailed case study on the transformation of the German football club Borussia Dortmund – as a model of commitment to the fight against antisemitism, setting an example for other European sports clubs and organizations. The club, which in the past served as fertile ground for the activities of neo-Nazi pseudo-fans, now takes an active and firm stand against antisemitism. Among other actions, the club conducts educational tours for young fans to concentration camps and works closely with Yad Vashem.

 

Link to the  full report: 

https://www.tau.ac.il/sites/default/files/media_server/General/sp/For%20a%20Righteous%20Cause%202023.pdf


Study offers new insight on what ancient noses smelled

Scientists compare humans' extinct genetic relatives to present-day people

Peer-Reviewed Publication

UNIVERSITY OF ALASKA FAIRBANKS

Neanderthal woman 

IMAGE: A RECONSTRUCTION OF A NEANDERTHAL WOMAN view more 

CREDIT: <A HREF="HTTPS://COMMONS.WIKIMEDIA.ORG/WIKI/FILE:RECONSTRUCTION_OF_NEANDERTHAL_WOMAN.JPG">BACON CPH</A>, <A HREF="HTTPS://CREATIVECOMMONS.ORG/LICENSES/BY/2.5">CC BY 2.5</A>, VIA WIKIMEDIA COMMONS

It sounds a little like Stone Age standup: A Denisovan and a human walk past a bees’ nest heavy with honeycomb. What happens next?

According to a study led by University of Alaska Fairbanks biological anthropologist Kara C. Hoover and Universite Paris-Saclay biochemist Claire de March, the Denisovan, with the species’ greater sensitivity to sweet smells, may have immediately homed in on the scent and beat the human to a high-energy meal.

"This research has allowed us to draw some larger conclusions about the sense of smell in our closest genetic relatives and understand the role that smell played in adapting to new environments and foods during our migrations out of Africa,” said Hoover, a professor in the Department of Anthropology at UAF.

A paper on the research, recently published in iScience, was written by collaborators from UAF, Duke University, Universite Paris-Saclay, Tokyo University of Agriculture and Technology, and the University of Manchester. The study investigated whether humans share a sense of smell with their now-extinct Denisovan and Neanderthal cousins, who left Africa about 750,000 years ago. Contemporary humans left Africa about 65,000 years ago.

To recreate the noses of our extinct genetic relatives and compare them to those of present-day people, the research team used publicly available genome sequences from multiple Neanderthals, one Denisovan and one ancient human. They used data from the 1000 Genomes project to represent modern humans.

They then compared 30 olfactory receptor genes from each group. The team found that 11 of the receptors had some novel mutations present only in extinct lineages. In the largest study of its kind to date, the team created laboratory versions of those 11 olfactory receptors and then exposed them to hundreds of odors at different concentrations. 

When the receptors detected an odor, they literally lit up. The speed and brightness of the luminescence told the scientists whether, how soon and to what degree each “nose” could smell the odors. While the receptors could detect the same things as modern humans, they differed in sensitivity to many of the odors.

“We literally reproduced an event that hadn’t happened since the extinction of Denisova and Neanderthal 30,000 years ago: an extinct odorant receptor responding to an odor in cells on a lab bench,” de March said. “This took us closer to understanding how Neanderthal and Denisova perceived and interacted with their olfactory environment.”

Neanderthals, who lived in Eurasia between 430,000 and 40,000 years ago, had the poorest sense of smell. For example, the Neanderthal from the Chagyrskaya Cave couldn’t detect the sex steroid androstadienone, which smells something like sweat and urine. That may have been useful, Hoover said, given that they were trapped in close quarters in caves during glacial maximums, when the ice sheets from the poles expanded southward and made many areas uninhabitable.

Denisovans have left behind less physical evidence than Neanderthals. They are known mostly from modern-day Siberia, where remains in the Denisova Cave were dated to between 76,200 and 51,600 years ago. Denisovans were generally more sensitive to odors than humans and much more sensitive than Neanderthals. They were most responsive to sweet and spicy smells like honey, vanilla, cloves and herbs. That trait could have helped them find high-calorie food.

Present-day humans fell somewhere in the middle.

“This is the most exciting research I have ever been involved in,” said co-author Matthew Cobb from the University of Manchester. “It shows how we can use genetics to peer back into the sensory world of our long-lost relatives, giving us insight into how they will have perceived their environment and, perhaps, how they were able to survive.”

In many species, olfactory receptors have been linked to their ecological and dietary needs.

"Each species must evolve olfactory receptors to maximize their fitness for finding food," said co-author Hiroaki Matsunami in a Duke University news release. "In humans, it's more complicated because we eat a lot of things. We're not really specialized."

Smell is integral to the human story, Hoover said. “Such a strongly overlapping olfactory repertoire suggests that our generalist approach to smelling has enabled us to find new foods when migrating to new places — not just us but our cousins who left Africa much earlier than us!”

 

Astral alchemy

Researchers at Osaka University participate in a particle accelerator experiment that creates an exotic, highly unstable particle and measures its mass, which may help explain the interior of ultra-dense neutron stars

Peer-Reviewed Publication

OSAKA UNIVERSITY

Fig. 1 

IMAGE: THE EXOTIC BARYON CALLED Λ(1405) AND A SCHEMATIC ILLUSTRATION OF THE EVOLUTION OF MATTER view more 

CREDIT: HIROYUKI NOUMI

Osaka, Japan – The Standard Model of particle physics tells us that most particles we observe are made up of combinations of just six types of fundamental entities called quarks. However, there are still many mysteries, one of which is an exotic, but very short-lived, Lambda resonance known as Λ(1405). For a long time, it was thought to be a particular excited state of three quarks—up, down, and strange—and understanding its internal structure may help us learn more about the extremely dense matter that exists in neutron stars.

Now, investigators from Osaka University were part of a team that succeeded in synthesizing Λ(1405) for the first time by combining a K- meson and a proton and determining its complex mass (mass and width). The K meson is a negatively charged particle containing a strange quark and an up antiquark. The much more familiar proton that makes up the matter that we are used to has two up quarks and a down quark. The researchers showed that Λ(1405) is best thought of as a temporary bound state of the K- meson and the proton, as opposed to a three-quark excited state.

In a study published recently in Physics Letters B, the group describe the experiment they carried out at the J-PARC accelerator. K mesons were shot at a deuterium target, each of which had one proton and one neutron. In a successful reaction, a K meson kicked out the neutron, and then merged with the proton to produce the desired Λ(1405). “The formation of a bound state of a K- meson and a proton was only possible because the neutron carried away some of the energy,” says an author of the study, Kentaro Inoue One of the aspects that had been perplexing scientists about Λ(1405) was its very light overall mass, even though it contains a strange quark, which is nearly 40 times as heavy as an up quark. During the experiment, the team of researchers was able to successfully measure the complex mass of Λ(1405) by observing the behavior of the decay products.

“We expect that progress in this type of research can lead to a more accurate description of ultra-high-density matter that exists in the core of a neutron star.” says Shingo Kawasaki, another study author. This work implies that Λ(1405) is an unusual state consisting of four quarks and one antiquark, making a total of 5 quarks, and does not fit the conventional classification in which particles have either three quarks or one quark and one antiquark. This research may lead to a better understanding of the early formation of the Universe, shortly after the Big Bang, as well as what happens when matter is subject to pressures and densities well beyond what we see under normal conditions.

###

The article, “Pole position of Λ(1405) measured in d(K,n)πΣ reactions,” was published in Physics Letters B at DOI: https://doi.org/10.1016/j.physletb.2022.137637.

The current work was performed by an international research collaboration, E31, involving scientists from Research Center for Nuclear Physics (RCNP), Osaka University together with RIKEN, KEK, JAEA, J-PARC, Tohoku University, INFN (Italy), SMI (Austria) and others.

  

Schematic illustration of the reaction used to synthesize Λ(1405) by fusing a K- (green circle) with a proton (dark blue circle), which takes place inside a deuteron nucleus

CREDIT

Hiroyuki Noumi

Fig. 3 (IMAGE)

OSAKA UNIVERSITY


Research representives:

Prof. Hiroyuki Noumi, RCNP, Osaka University/IPNS, KEK

Dr. Fuminori Sakuma, RIKEN Cluster for Pioneering Research, RIKEN

Dr. Tadashi Hashimoto, Advanced Science Research Center, JAEA

Prof. Hiroaki Ohnish, Research Center for Electron Photon Science, Tohoku University

Prof. Catalina Curceanu, Laboratori Nazionali di Frascati, INFN

Prof. Johannes Zmeskal, Stefan-Mayer-Institut für subatomare Physik

About Osaka University

Osaka University was founded in 1931 as one of the seven imperial universities of Japan and is now one of Japan's leading comprehensive universities with a broad disciplinary spectrum. This strength is coupled with a singular drive for innovation that extends throughout the scientific process, from fundamental research to the creation of applied technology with positive economic impacts. Its commitment to innovation has been recognized in Japan and around the world, being named Japan's most innovative university in 2015 (Reuters 2015 Top 100) and one of the most innovative institutions in the world in 2017 (Innovative Universities and the Nature Index Innovation 2017). Now, Osaka University is leveraging its role as a Designated National University Corporation selected by the Ministry of Education, Culture, Sports, Science and Technology to contribute to innovation for human welfare, sustainable development of society, and social transformation.

Website: https://resou.osaka-u.ac.jp/e