Friday, May 26, 2023

Collective property rights spark spirit of cooperation that extends beyond managing land

Peer-Reviewed Publication

UNIVERSITY OF COLORADO AT BOULDER

When people come together to manage collectively owned natural resources like forests, they may become more cooperative and trusting overall, according to recent research led by CU Boulder.

The study takes a new look at what has become a growing trend around the world: Since the 1990s, groups like the Yuracaré of Bolivia and residents of the village of Mpunda in Uganda have fought for, and secured, collective property rights to the land they live on. Individuals don’t own this land. Instead, the communities own and manage wide swaths of woodlands together, deciding when to harvest or plant new trees free from most outside interference.

Previous studies have suggested that such agreements may be good for the environment—forests, in particular, may flourish under collective property rights. 

The new research, however, shows that such rights can also have much broader, although more subtle, impacts on people. 

“We found that communities who got collective rights to their forests were able to improve how they interact with each other during forest-related activities, like harvesting trees,” said Komal Preet Kaur, lead author of the study and a doctoral student in political science at CU Boulder. “We would expect that. But they were also more cooperative around non-forestry activities, such as working on community projects, which was really surprising.”

Krister Andersson, co-author of the study and professor of political science, sees the findings as a rare bit of good news in the world of conservation. Collective land rights, in many cases, line up with how Indigenous peoples have interacted with and cared for natural resources for centuries.

“Environmental activists and scholars are really bad at paying attention to good news. We always ring the alarm bells,” Andersson said. “But one of the really positive stories when it comes to forests is that governments are increasingly recognizing the ancestral rights of Indigenous peoples to their lands.”

Building pride

The road to that recognition, however, can be long.

Take the Yuracaré. These Indigenous people live around the Chapare River of central Bolivia, a region of rich tropical forests where palm and wild cocoa trees abound. There, they harvest bananas and yucca and fish and hunt for game. 

In the mid-1990s, following decades of activism from Indigenous groups, the Bolivian government passed a series of bills aimed at reforming the nation’s land rights. The government redistributed control of more than 65,000 square miles of land, much of it forested. Today, the Yuracaré oversee a 954-square-mile tract of forest and farmland. They make decisions about these resources through an assembly, which includes representatives from multiple “corregimientos,” or coalitions of neighboring families.

In the new study, Andersson and his colleagues set out to discover what kinds of impacts land reforms could have on the psychology of people like the Yuracaré. 

“When you see a community that has engaged in all these struggles to get recognition, and then they are recognized by the national authorities, they present themselves in a whole different way,” Andersson said. “They carry themselves with more pride.”

Forestry games

The team gathered information on 213 groups living in 10 countries recorded in the International Forestry Resources and Institutions (IFRI) dataset. This resource, led by Indiana University and University of Michigan, includes data on how communities around the world manage their natural resources. Some of the communities held collective rights to forests, while others didn’t.

The researchers also traveled to Bolivia and Uganda where they invited local forest users to workshops where they played “behavioral games” to gauge their ability to solve a collective problem. Teams of eight people sat around a table stacked with wooden blocks representing trees in a shared forest. Over a series of rounds, they decided how many of these blocks to harvest. If too many of the players pursued short-term profits, the forest would disappear quickly. 

“There's a tension,” Andersson said. “You have to decide: Do I go in and grab as many trees as I can to make a quick buck in the short term? Or do I try to cooperate with the others so that everyone wins?”

The researchers could easily spot the differences between the behavior of people who held the rights to their forests versus those who didn’t: Players from groups with colletive property rights were more cooperative during the game, on average. They talked over their agreements and plans and seemed to trust each other more. 

Drawing on the IFRI dataset, the researchers also discovered that communities with collective land rights scored higher on several measurements of cooperation. They tended to collaborate more on community projects, such as maintaining roads or digging wells. In all, those communities were about 10% more cooperative when it came to non-forestry activities than groups without collective land rights. 

For Kaur, the study shows that such collective property rights may be a good approach not just for protecting forests—but also for helping knit people together.

“Indigenous communities and local people who have been using these resources for generations have been disrupted because of colonialism,” she said. “It’s time the governments give their due rights back.”

Scepticism about Microsoft results

Peer-Reviewed Publication

UNIVERSITY OF BASEL

Majorana particles 

IMAGE: DISORDER IN VERY THIN NANOWIRES CAN LEAD TO MEASUREMENT RESULTS THAT COULD BE MISINTERPRETED AS EVIDENCE FOR MAJORANA PARTICLES. view more 

CREDIT: UNIVERSITY OF BASEL, DEPARTMENT OF PHYSICS

In March 2022, Microsoft published research results about the realisation of a special type of particle that might be used to make particularly robust quantum bits. Researchers at the University of Basel are now calling these results about so-called Majorana particles into doubt: through calculations they have shown that the findings can also be explained differently.

In 1938 a genius suddenly vanished without a trace: after buying a ferry ticket from Palermo to Naples, the young Italian physicist Ettore Majorana seemingly disappeared from the face of the earth. Just a few months earlier he had postulated a highly unusual type of particle. These particles were supposed to be their own anti-particles and carry no electric charge.

In the last few years, among physicists there has been a renewed interest in these mysterious particles, which bear the name of their missing inventor (whose disappearance has not been explained to this day). The particles, it turns out, might possibly be used as particularly robust quantum bits in quantum computers.

The biggest obstacle in the construction of such computers, which promise unbelievable computing power, is decoherence – the fact, in other words, that disturbances from the environment can very quickly destroy the sensitive quantum states with which quantum computers perform calculations. If, however, one could use Majorana particles as quantum bits, that problem could solved instantly since they have a built-in immunity against decoherence because of their special properties.

Dampened expectations

In a study published in the scientific journal Physical Review Letters, researchers at the University of Basel have now dampened expectations of using Majorana particles for computation in the near future. The team led by Prof. Jelena Klinovaja showed that results published by Microsoft in 2022, according to which Majorana particles had been detected in the labs of the company, may not hold water after all.

“The path that Microsoft is taking with their experiments is certainly the right one,” says Richard David Hess, PhD student and first author of the study, “but our calculations suggest that the measurement data can also be explained by other effects that having nothing to do with Majorana particles.”

Looking for exotic particles is detective work of the highest order, and investigators have to rely on just a few clues. They look for these clues using a nanowire made of a semiconductor material, a thousand times thinner than a human hair, coupled to a superconductor. In such a system, it is suspected, electrons and holes in the semiconductor could pair up to make quasiparticles that behave like Majorana particles.

Characteristic anomalies

Through conductance measurements the experts at Microsoft had detected an anomaly that is characteristic of such Majorana states and also shown that the superconducting properties of the superconductor-nanowire-combination respond to an applied magnetic field in a way that suggests the presence of a so-called topological phase.

In mathematics, topology can be illustrated by looking, for instance, at a coffee cup with a handle (a “hole”) that can theoretically be deformed into a doughnut (which also has a “hole”, so both are topological equal) but not into a sphere (no “hole”). In Majorana states, by contrast, topology is responsible for their much coveted immunity to decoherence.

“We have now mathematically modelled the experiments by Microsoft and tried to find out whether the measurements could have other – ‘trivial’, in scientific jargon – explanations”, explains Henry Legg, a postdoc in Klinovaja’s group. In fact, the Basel researchers came to the conclusion that both the current anomaly and the superconducting properties can be reproduced by a small amount of disorder from impurities inside the nanowire.

“Our results show clearly that disorder plays an important role in such experiments”, says Jelena Klinovaja. To detect Majorana states unambiguously and also put them to use in quantum computers, one will eventually need even purer nanowires. This also means that there will be no lack of experimental challenges in the next few years.

A detailed map of Urban Heat Islands

Peer-Reviewed Publication

CMCC FOUNDATION - EURO-MEDITERRANEAN CENTER ON CLIMATE CHANGE

Risk assessment in Turin 

IMAGE: MAPPING THE UHI RISKS (R.01; R.02) AND THE PRIORITIZED AREAS FOR INTERVENTION (R.03). view more 

CREDIT: CMCC FOUNDATION

Urban areas are where the majority of the world’s population lives, and they are also usually most affected by climate change. Heat waves and extreme temperatures are more intense in heavily-built areas, intensifying existing weaknesses and inequalities among the urban population.

An interdisciplinary study published in the Urban Climate journal and led by the CMCC Foundation focuses on the Urban Heat Island phenomenon, providing a reproducible and flexible methodology to explore the risk assessment on the heat-health nexus within the city of Turin, Italy.

The Urban Heat Island (UHI) is defined as ​​a temperature difference between urban and rural areas, caused by the excess of heat emitted and by the solar gain trapped by the urbanized environment. “The UHI phenomenon is typical of urban areas and it is stronger during heat waves events,” said Marta Ellena, of the CMCC’s REgional Models and geo-Hydrological Impacts (REMHI) division, and first author of the paper. “This happens because cities are mostly covered by impermeable surfaces, and this makes temperatures higher, worsening the already existing UHI effect.”

The main objective of the study was to produce climate risk assessment evaluations at the local scale taking under consideration the main drivers of inequality, which are crucial for suggesting adaptation strategies for more climate-resilient and sustainable cities.

An important feature of the study was the identification of the UHI risk per census tract, which is the minimum geographical entity of data collection currently available from Italian municipalities. “This is one of the most innovative aspects of this work,” said Ellena, “because previous studies considered city’s quarters or districts. For example, Turin has 23 quarters and 8 districts: in this study we considered its census tracts, which are 3843, so it is an enormous set of information, especially compared to previous studies.”

The research was carried out adopting an up-to-date theoretical framework proposed by the Intergovernmental Panel on Climate Change (IPCC), and applying it on the urban area of Turin, the fourth most populated Italian urban area.

The UHI-related risk is described in this framework as a combination and interaction of three main factors: hazard, exposure, and vulnerability.

The climate hazard is represented by the UHIs and their distribution within the city boundaries; exposure refers to the presence of vulnerable citizens in urban areas who are likely to be adversely affected by the occurrence of UHI phenomena: in this case, the population aged 65 or over. Finally, vulnerability is defined as made up of two factors, sensitivity and adaptive capacity. Sensitivity is composed of the elements which contribute to the susceptibility of the exposed population considered, such as demographic and socioeconomic factors, health conditions and the environmental context of the urbanized area. Adaptive capacity, on the other hand, takes into consideration the availability of facilities and services which contribute to more favorable conditions for individuals under extreme temperatures.

“The combination of all these different factors allows us to express the complexity of the concept of risk associated with Urban Heat Islands,” said Guglielmo Ricciardi, of CMCC and Politecnico di Torino, another author of the study. “It’s not only greener or more urbanized areas that influence the risk on citizens. We should also consider the characteristics of buildings, the proximity to hospitals, or to public spaces with air conditioning, among others.”

The results were collected in tables and visualized through georeferenced maps for individual and aggregated indicators, and are open access and available under a creative commons license.

The results of the study allowed for the identification of UHIs in the city of Turin, and the associated risk for the population, as well as the priority areas for intervention on a highly detailed scale. While the lowest hazard was measured in green areas corresponding with the main urban parks, thus demonstrating the significant contribution of vegetation to heat reduction, higher-risk zones are mostly located in the densely populated areas of the suburbs.

“A strength of this work is that such a high-resolution analysis of the connection between the UHI hazard, the population exposure, and the related vulnerabilities at the urban level is still uncommon,” said Ellena, “and we hope it will be used by policymakers for informed decisions and adaptation measures, or by other researchers as a guidance to reproduce similar analyses in other Italian (and not Italian) urban contexts”.

 

More information:

Overfishing and degradation, causes of the decline of marine ecosystems in the South Atlantic Ocean in recent decades

Peer-Reviewed Publication

UNIVERSITAT AUTONOMA DE BARCELONA

The marine ecosystems of the South Atlantic Ocean have experienced a significant decline in recent decades due to overfishing and habitat degradation. This is demonstrated by a scientific study led by the Institute of Environmental Science and Technology of the Universitat Autònoma de Barcelona (ICTA-UAB) that sheds light on the magnitude of human impact on these once thriving marine areas based on the archaeological analysis of fish remains from several sites in Brazil. 

The indigenous communities that inhabited the southern coast of Brazil for thousands of years enjoyed abundant and diverse marine ecosystems teeming with large, high trophic level fish and top predators that played an important role in their food security in the past. This allowed their periodic exploitation by indigenous populations with simple fishing technology for thousands of years. After comparing the archaeological remains of fish species from the past with the present-day fish populations, the results show a significant decrease in many of the species, particularly sharks and rays, possibly linked to the escalating human impacts, such as overfishing and habitat degradation in recent decades. 

Thiago Fossile, lead author and researcher at ICTA-UAB and the UAB Department of Prehistory, emphasizes the growing anthropogenic pressures faced by aquatic fauna in Brazil, a country known for its stunning beaches and diverse wildlife. "Many species documented in archaeological sites are now endangered, while for other species there is insufficient data on their distribution and abundance. By using archaeological data, we can gain insight into these lost environments and can redefine conservation baselines”. 

André Colonese, senior author of the study and researcher at ICTA-UAB and the Department of Prehistory at UAB, highlights the importance of coastal and marine ecosystems in sustaining subsistence fisheries for thousands of years along the Brazilian coast. "Hundreds of archaeological sites provide valuable information on past biodiversity, contributing to discussions on fisheries management and conservation. This study, published in PLoS ONE, emphasizes the significance of incorporating archaeological data into conservation debates in Brazil, enhancing the discipline’s relevance to environmental issues". 

For Mariana Bender, co-author from the Universidade Federal de Santa Maria, the study offers a new perspective into the understanding of the exploitation of fish biodiversity through time. “It is amazing what archeological sites can tell us relative to the impacts of ancient human populations on fish biodiversity. Looking at fish characteristics we found evidence that large top predators have long been exploited and recent fisheries have moved towards lower trophic levels. This process is not recent, but instead, has been in place for thousands of years”, she says. 

Co-author Dione Bandeira of the Universidade da Região de Joinville (Brazil) explained that "Indigenous environmental stewardship serves as a model for sustainable resource utilization and plays a crucial role in conserving biodiversity in tropical and subtropical regions of South America. Additionally, studies focusing on archaeological faunal remains provide valuable insights into the origins and evolution of these enduring practices”. 

The study was funded by the ERC TRADITION project (Consolidator Grant 817911) and led by researchers from ICTA-UAB (Spain), in collaboration with the Rheinische Friedrich-Wilhelms-Universität (Germany), Universidade de São Paulo (Brazil), Universidade Federal de Pelotas (Brazil), Universidade Federal do Rio Grande (Brazil), Universidade da Região de Joinville (Brazil) and Universidade Federal de Santa Maria (Brazil). 

 

ABOLISH THE SECOND AMENDMENT

Association of community vulnerability and state gun laws with firearm deaths in children and adolescents

JAMA Network Open

Peer-Reviewed Publication

JAMA NETWORK

About The Study: In this study including 5,813 youths ages 10 to 19 who died of an assault-related firearm injury, socially vulnerable communities in the U.S. experienced a disproportionate number of assault-related firearm deaths among youths. Although stricter gun laws were associated with lower death rates in all communities, these gun laws did not equalize the consequences on a relative scale, and disadvantaged communities remained disproportionately impacted. While legislation is necessary, it may not be sufficient to solve the problem of assault-related firearm deaths among children and adolescents. 

Authors: Deepika Nehra, M.D., of the University of Washington in Seattle, is the corresponding author. 

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ 

doi:10.1001/jamanetworkopen.2023.14863

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

Activity sessions in daycare already nurturing emotional skills by 10 weeks

Researchers from the University of Helsinki investigated the impact of two Finnish-designed emotional skill interventions in daycare centres.

Peer-Reviewed Publication

UNIVERSITY OF HELSINKI

Concerns are growing about the wellbeing of children and adolescents and their increasing inequality in Finland. Early childhood education and care provides an environment where these concerns can be addressed as early as possible, particularly by supporting children's social-emotional development. 

Social-emotional development denotes, among other things, the development of children’s emotional and interactive competencies.

Research on the topic remains scarce in Finland

“Even though there is international research on supporting social-emotional development, there is still little scholarly evidence on the impact of support measures. In our project, we wanted to investigate the impact of two Finnish methods designed for use in daycare centres,” says Postdoctoral Researcher Silja Martikainen.

The daycare centres under study utilised SAGA, a technique of shared storybook reading developed by Professor Mirjam Kalland, whereby children are encouraged to identify the thoughts and emotions of the characters in the stories and describe them. 

The other method utilised constituted art-based activities built around an animation character named Pikkuli created by Metsämarja Aittokoski, with episodes of the animated series, books and music as the material. Pikkuli emotion cards also were used in support of advancing emotional competence. Early childhood educators were trained in implementing both interventions. 

Both interventions supported children’s development

Over 10 weeks, a total of 150 children from 15 different daycare groups participated in the study. At the time, the social-emotional development of the children involved in the intervention sessions was compared with that of a group engaged in regular small group activities.

The study found that both interventions, SAGA and Pikkuli, strengthened children’s ability to help and support other children and reduced internalising problems including withdrawn behaviour and symptoms of depression and anxiety. 

In addition, social orientation in relationships was advanced in the children who took part in the SAGA sessions, while their difficulties in focusing or getting into conflicts with others were reduced. No change was observed in these areas in the control group.

Positive experiences of the interventions among early childhood educators

The experiences of early childhood educators were positive. 

“The staff involved in SAGA interventions stated that the model was an easily deployable addition during regular reading sessions. Children’s profound thoughts on emotions even surprised the staff,” says Kalland.

The experiences of the staff involved in Pikkuli activities were also positive. According to Metsämarja Aittokoski, the creator of Pikkuli, the staff felt that the children’s ability to talk about emotions was boosted during the study. 

“After the study, the Pikkuli model has been further developed and the content expanded on the basis of the results,” Aittokoski adds.

“The research findings are encouraging, and the goal is for the methods found to be effective to remain part of regular early childhood education and care. In this too, sufficient human resources must be taken into consideration,” Silja Martikainen notes.

The study received funding from Business Finland and the Swedish Cultural Foundation in Finland.

Original article: Silja Martikainen, Mirjam Kalland, Tanja Linnavalli, Kaisamari Kostilainen, Metsämarja Aittokoski, Jyrki Reunamo, Zoi Vasileiou & Mari Tervaniemi (2023) Supporting social-emotional development in early childhood education and care – a randomized parallel group trial evaluating the impact of two different interventions. Scandinavian Journal of Educational Research

For more information, please contact: Postdoctoral Researcher Silja Martikainen, phone +358 (0) 50 350 6848, silja.martikainen@helsinki.fi

Living in an almshouse boosts life expectancy, study finds

Living in an almshouse can boost the longevity of its residents by as much as two-and-a-half years compared to their counterparts in the general population, according to a new Bayes Business School report.

Reports and Proceedings

CITY UNIVERSITY LONDON

Living in an almshouse can boost the longevity of its residents by as much as two-and-a-half years compared to their counterparts in the general population, according to a new Bayes Business School report.

Almshouses provide affordable community housing for local people in housing need. They are generally designed around a courtyard to provide a ‘community spirit’, that is synonymous with the almshouse movement. They offer independent living but provide friendship and support when needed.

Analysing up to 100 years’ worth of residents’ records from various almshouses in England, the research suggests that living in these communities can reduce the negative impact on health and social wellbeing which is commonly experienced by the older population in lower socioeconomic groups, particularly those individuals who are living in isolation.

The results are very encouraging. They show that, for several of the almshouses included in the study, residents can expect to live as long as wealthier members of the general population despite coming from the most deprived quintile. This shows that the disparity in longevity and health outcomes could be mitigated even after reaching retirement age, provided a suitable social infrastructure can be put in place.

The report, authored by Professor Ben Rickayzen, Dr David Smith, Dr Anastasia Vikhanova and Alison Benzimra, concludes that almshouses could help the Government’s aims to reduce inequalities in mortality, which are observed between socioeconomic groups, by reducing the social isolation experienced by many in the older population.

Titled ‘Almshouse Longevity Study – Can living in an almshouse lead to a longer life?’, the report’s key findings are:

  • Residents in almshouses in England receive a longevity boost relative to people of the same socioeconomic group from the wider population.
  • The best-performing almshouses in the study so far have shown a longevity boost which increases life expectancy to that of a life in the second-highest socioeconomic quintile – a remarkable outcome.
  • As an example, the authors estimate that a 73-year-old male entering an almshouse such as The Charterhouse today would receive a longevity boost of 2.4 years (an extra 15% of future lifetime at the point of joining) compared to his peers from the same socioeconomic group, and 0.7 years when compared to an average 73-year-old from the general population.
  • This longevity boost could be due to both the strong sense of community and social belonging within almshouses which lead to better physical and mental health. Enhanced wellbeing helps to mitigate loneliness which is endemic in older age groups.

Professor Ben Rickayzen, Professor of Actuarial Science at Bayes Business School, said:

“It is well known that, on average, the lower a person’s socioeconomic status, the lower their life expectancy. However, intriguingly, our research has found that this doesn’t have to be the case. We discovered that many almshouse residents receive a longevity boost when compared to their peers of the same socioeconomic status from the wider population.

“More research is needed to ascertain exactly what factors cause almshouse residents to have a longer life; however, we postulate that it is the sense of the community that is the most powerful ingredient. For example, a common theme within the almshouses included in the study is that they encourage residents to undertake social activities and responsibilities on behalf of their fellow residents. This is likely to increase their sense of belonging and give them a greater sense of purpose in their everyday lives while mitigating against social isolation.

“We would encourage the Government to invest in retirement communities, such as almshouses, which would be in keeping with their overarching levelling up agenda. While this agenda is commonly associated with enhancing equality on a regional basis, it is important that levelling up should also aim to combat health inequalities experienced by people from lower socioeconomic groups across the country. There is an opportunity to improve the Government’s levelling up agenda by incorporating the best features of communal living into their social housing policy. This should make a significant difference to the quality of life experienced by the older population across the UK.

“The findings from this research are important as they could offer solutions to the social care problems currently being experienced in the UK.”

Alison Benzimra, a co-author of the report and Head of Research at United St Saviour’s Charity, said:

“Many almshouse trustees and staff members anecdotally believe that almshouse living is beneficial for residents. The results from this study demonstrate that the community spirit provided by almshouses does in fact result in longer life expectancy. These findings are encouraging to those living and working in the almshouse community and provide the motivation to continue to explore what it is about almshouses’ physical design and support services that result in positive outcomes for older residents. This study strengthens the case that this historic form of housing is addressing the evolving needs of older people living in our modern-day society.”

Nick Phillips, CEO, The Almshouse Association, said:

“We are delighted to read this report. It is further evidence that the almshouse model – 1,000 years after its inception – seems to be adding something special to the lives of residents. There is a growing body of research that is suggesting this model of community housing seems to be right for the future. This must now beg the question, where are the philanthropists to lead this robust charity housing model into the next century?”

Susan Kay, Chief Executive of Dunhill Medical Trust, said:

“It’s been great to support this piece of work and to see it take its place in the wider body of work about the characteristics of age-friendly living spaces and supportive communities. A one-hundred-year life is now a realistic expectation and we need to build on this learning to create the homes and communities that will be so important for the health and wellbeing of us all.”

Nigel Hulme, a resident of the United St Saviour’s Charity almshouse, explained how much living in the almshouse has helped him in his later years:

“Moving to Hopton’s Gardens has been a godsend. To have a roof over my head has helped me to deal with my addiction issues, and having the support from the staff and my neighbours has made my recovery possible.”

 

Download the full report: Almshouse Longevity Study – Can living in an almshouse lead to a longer life?

The study was sponsored by the Dunhill Medical Trust and the Justham Trust and was supported by The Almshouse Association

Cleft lip caused by combination of genes and environment

Peer-Reviewed Publication

UNIVERSITY COLLEGE LONDON

A cleft lip or palate arises from the combined effects of genes and inflammatory risk factors experienced during pregnancy, such as smoking or infections, finds a new study led by UCL researchers.

The study, published in Nature Communications, has revealed for the first time how genetic and environmental factors come together to form a cleft lip or palate in a developing foetus.

Cleft lip, with or without cleft palate, is the most common craniofacial malformation seen at birth, affecting one in 700 live births. It can have devastating consequences for babies and their families, as the infants may experience difficulty feeding, speaking, and hearing, and may be at increased risk for ear infections and dental problems.

Senior author Professor Roberto Mayor (UCL Cell & Developmental Biology) said: “It has been known for some time that there is a genetic component to cleft lip, and that some environmental factors such as smoking, stress, infections and malnutrition during pregnancy can also increase the risk of cleft lip. Here, for the first time we have shown how these two factors work together, and why both genetic and environmental risk factors are necessary for a child to be born with cleft lip.”

The researchers, based at UCL and the University of São Paulo, were studying families who carry mutations in the e-cadherin gene, which is known to be implicated in cleft lip, but noted that not everyone with the mutation develops a cleft lip. They reproduced this mutation in mice and frogs, which generated malformations similar to the cleft lip in humans, but only when the mice and frogs carrying the mutation were also exposed to inflammation-causing environmental factors. The researchers also found similar effects in human stem cells with both the mutation and inflammation.

The e-cadherin protein plays a role in foetal development, as neural crest cells – the embryonic stem cells that form facial features – move together to form the face. In normal development, the neural crest cells migrate together in two halves, wrapping around the head, before joining together to form the face. This requires e-cadherin to act as a glue between cells. If the two halves of the neural crest cells do not fully bind together, the infant will be born with a cleft lip or palate.

The mutation identified by the researchers reduces the production of the e-cadherin protein, as DNA methylation reduces transcription, but they found that the mutation alone did not reduce e-cadherin levels enough to cause a cleft lip. It was only when a foetus with the mutation was also exposed to environmental risk factors that drive inflammation throughout the body (which can include smoking, stress, malnutrition or infections), that DNA methylation was increased and e-cadherin levels were too low for the neural crest cells to bind themselves together to fully form the lip and palate.

First author Dr Lucas Alvizi (UCL Cell & Developmental Biology) said: “Our study is the first to demonstrate in detail how genetic and environmental factors combine to cause a birth defect, while it is also a noteworthy example of epigenetics, as environmental factors influence the expression of a gene.”

The researchers hope that their findings will contribute to the development of new treatments or preventative strategies for cleft lip or palate, and clarify the risk factors to help people reduce the chance their baby will develop the condition.

Professor Mayor said: “Testing for this mutation could be a straightforward part of antenatal care, so that if someone carries the mutation, they would be advised to take steps to reduce the risk of inflammation that could combine with the genetic factor to result in a cleft lip. In addition to targeting factors such as smoking, the prescription of anti-inflammatory drugs may also help for at-risk pregnant women.”

The study was supported by the Sao Paulo Research Foundation, CEPID-FAPESP (Brazil), Medical Research Council, Biotechnology and Biological Sciences Research Council, and Wellcome.

IVI and the Ministry of Health and Welfare of the Republic of Korea urge global action on enhancing vaccine manufacturing during the 76th World Health Assembly


IVI and the Government of the Republic of Korea hosted an event on the sidelines of the World Health Assembly with co-sponsoring countries Brazil, Ghana, Kenya, Rwanda, Sweden, and Thailand

Meeting Announcement

INTERNATIONAL VACCINE INSTITUTE

IVI-MOHW ROK Side Event at WHA76 

IMAGE: "EMPOWERING LOCAL BIOMANUFACTURING: HOW TO EQUIP COUNTRIES FOR CURRENT AND FUTURE INFECTIOUS DISEASE OUTBREAKS" BROUGHT TOGETHER MINISTERS OF HEALTH AND GLOBAL HEALTH AND IMMUNIZATION LEADERS TO DISCUSS NEEDS FOR A GLOBAL BIOMANUFACTURING WORKFORCE AND INFRASTRUCTURE. view more 

CREDIT: IVI

The International Vaccine Institute (IVI), an international organization with a mission to discover, develop, and deliver safe, effective, and affordable vaccines for global health, and the Ministry of Health and Welfare (MOHW) of the Republic of Korea gathered ministers of health and global health and immunization leaders for Empowering local biomanufacturing: How to equip countries for current and future infectious disease outbreaks, a side event of the 76th World Health Assembly.

 

Sponsored by Brazil, Ghana, Kenya, Rwanda, Sweden, and Thailand, this event brought together officials from governments and the public and private sectors to discuss needs and opportunities for a coordinated and highly skilled global biomanufacturing workforce and infrastructure.

 

Dr. Jerome Kim, Director General of IVI, said: “Increasing the global capacity to manufacture vaccines and other health products is a critical factor in ensuring countries are able to respond to outbreaks of endemic and emerging infectious diseases with equity and efficiency. In IVI’s first year with observer status at the World Health Assembly, we are proud to organize this side event with the Republic of Korea, an urgent and complementary conversation to our ongoing efforts to train a biomanufacturing workforce through the Global Training Hub for Biomanufacturing.”

 

Dr. Youngmee Jee, Commissioner of the Korea Disease Control and Prevention Agency, said: “Korea was designated as a global bio human resource training institution last year and is already conducting the educational program…I hope countries around the world are able to advance their ability to access vaccines equally.”

 

The Honorable Kwaku Agyeman-Manu, Minister for Health of Ghana; Sir Jeremy Farrar, Chief Scientist of the WHO; and Olivia Wigzell, Director-General of Sweden’s National Board of Health and Welfare, gave high-level remarks to open the discussions.

 

The event continued with three sessions:

  • Sharing the best practices of WHO member states and their strategies, where country representatives spoke on learnings from the COVID-19 pandemic and efforts to build up local vaccine manufacturing capacity.
    • HWANG Seung Hyun, Director General, Global Vaccine Hub, Ministry of Health and Welfare, Republic of Korea
    • Tiago Rocca, Director of Strategic Partnerships and New Businesses, Instituto Bhutantan, Brazil
    • Rabera Kenyanya, Kenya BioVax Institute, Kenya
    • Dr. Yvan Butera, Minister of State, Ministry of Health, Rwanda
    • Nakorn Premsri, Director, National Vaccine Institute, Thailand

 

  • Global biomanufacturing capacity-building programs, where IVI and Korean industry partners discussed the operations and takeaways of the Global Training Hub for Biomanufacturing program.
    • Manki Song, Deputy Director General of Science, IVI
    • LEE Jin Woo, K-NIBRT
    • CHA Sang Hoon, Chairman, K-BIO Health

 

  • Gaps and challenges for global biomanufacturing capacity-building and fostering opportunities with better international cooperation mechanisms, a panel discussion moderated by IVI and featuring leaders from CEPI and the WHO.
    • Jerome Kim, Director General, IVI
    • William Ampofo, Chairman, African Vaccine Manufacturing Initiative
    • Frederik Kristensen, Deputy CEO, Coalition for Epidemic Preparedness Innovations
    • Rogério Gaspar, Director, Regulation and Prequalification, WHO

 

Empowering local biomanufacturing: How to equip countries for current and future infectious disease outbreaks took place on Tuesday, May 23, 2023, at the Hotel President Wilson in Geneva.

 

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About the International Vaccine Institute (IVI)
The International Vaccine Institute (IVI) is a non-profit international organization established in 1997 at the initiative of the United Nations Development Programme with a mission to discover, develop, and deliver safe, effective, and affordable vaccines for global health.

IVI’s current portfolio includes vaccines at all stages of pre-clinical and clinical development for infectious diseases that disproportionately affect low- and middle-income countries, such as cholera, typhoid, chikungunya, shigella, salmonella, schistosomiasis, hepatitis E, HPV, COVID-19, and more. IVI developed the world’s first low-cost oral cholera vaccine, pre-qualified by the World Health Organization (WHO), and developed a new-generation typhoid conjugate vaccine that is currently under assessment for WHO PQ.

IVI is headquartered in Seoul, Republic of Korea with a Europe Regional Office in Sweden and Collaborating Centers in Ghana, Ethiopia, and Madagascar. 39 countries and the WHO are members of IVI, and the governments of the Republic of Korea, Sweden, India, and Finland provide state funding. For more information, please visit https://www.ivi.int.

 

 

About the Global Training Hub for Biomanufacturing (GTH-B)

The COVID-19 pandemic tragically demonstrated that the international community is only safe when everyone is safe. Vaccines were a primary line of defense against COVID-19, helping some, but not all, countries overcome and build back from the pandemic. A grave imbalance of vaccine access and equity halted global recovery.

To secure vaccines and better prepare for current and future outbreaks, low- and middle-income countries around the world have seriously taken into consideration the need to build local vaccine manufacturing capacity. To meet this need, a critical resource gap is the availability of skilled, trained personnel in this highly technologically demanding field. To support these countries, the Korean Ministry of Health and Welfare (MOHW) established “Global Bio Manufacturing Workforce Training” with support from the WHO, including WHO Academy.

IVI administers training courses through this global program, the first of its kind supported by the Government of Korea, to provide essential, practical knowledge designed to strengthen professional capacity in all aspects of biomanufacturing.