Wednesday, June 28, 2023

DECRIMINALIZE DRUGS

Easier access to opioid painkillers may reduce opioid-related deaths


Peer-Reviewed Publication

RUTGERS UNIVERSITY




Increasing access to prescription opioid painkillers may reduce opioid overdose deaths in the United States, according to a Rutgers study.

“When access to prescription opioids is heavily restricted, people will seek out opioids that are unregulated,” said Grant Victor, an assistant professor in the Rutgers School of Social Work and lead author of the study published in the Journal of Substance Use and Addiction Treatment. “The opposite may also be true; our findings suggest that restoring easier access to opioid pain medications may protect against fatal overdoses.”

America’s opioid crisis has evolved across several waves, with each increasingly fatal. Wave one, which began in the 1990s, was associated with overdose deaths because of the misuse of opioid medications.

A policy implemented during the initial wave was the creation of prescription drug monitoring programs (PDMPs), state-based initiatives that track controlled substance prescribing. While the policy made it more difficult to access prescription opioids and rates of prescribing did decrease, it had the unintended consequence of pushing people toward off-market opioids, raising the risk of accidental death, said Victor.

This led to wave two of the crisis, a surge in heroin-related deaths, beginning around 2010, followed by wave three (which started in 2013), fueled by synthetic opioids such as fentanyl.

To measure trends and sociodemographic disparities in access to buprenorphine – a common treatment for opioid use disorder – and opioid painkillers, the researchers examined toxicology data, death records, and available PDMPs from 2,682 accidental overdose deaths that occurred from 2016 to 2021 in Indianapolis, Indiana.

The researchers found fewer than half of all decedents (43.3 percent) had a PDMP record of any kind, meaning they didn’t even try to access prescription opioids. Of the 10.6 percent that had been prescribed buprenorphine, most (64.7 percent) were prescribed treatment more than 30 days prior to death, suggesting they were not actively seeking treatment.

Victor and collaborators also found racial disparities in buprenorphine and opioid prescription trends, with dispersal for Blacks significantly lower than whites (7.3 percent and 21.9 percent versus 92.7 percent and 77.7 percent, respectively).

“Buprenorphine uptake is associated with significantly reduced rates of nonfatal and fatal overdose,” the researchers wrote. “Despite these positive treatment outcomes, several barriers remain to the widespread uptake of [medications for opioid use disorder] in the United States,” such as stigma and cost.

“For these reasons, a lack of adequate buprenorphine prescribing, combined with reductions in the availability of opioid analgesics, have left individuals contending with [opioid use disorder] at an elevated risk of overdose,” they concluded.

Given these trends and past research, Victor said it is time to re-evaluate policies that make it nearly impossible to obtain opioid prescriptions, even for those with a legitimate need.

“A big reason that we have such a problem with addiction in this country is because people can't access legitimate pain medication,” he said. “Our findings support a change in policy.”

Penn State researchers use ultrasound to control orientation of small particles


The demonstration has implications for drug delivery and bioprinting, according to scientists


Peer-Reviewed Publication

PENN STATE

Igor Aronson 

IMAGE: PENN STATE BIOMEDICAL ENGINEERING GRADUATE STUDENT LEONARDO DOMINGUEZ RUBIO, LEFT, AND PENN STATE DOROTHY FOEHR HUCK AND J. LLOYD HUCK CHAIR PROFESSOR OF BIOMEDICAL ENGINEERING IGOR ARONSON ARE PART OF A TEAM THAT USED ULTRASOUND TECHNOLOGY AND A NOZZLE TO SEPARATE, CONTROL AND EJECT DIFFERENT PARTICLES BASED ON THEIR SHAPE AND VARIOUS PROPERTIES. view more 

CREDIT: PENN STATE COLLEGE OF ENGINEERING




UNIVERSITY PARK, Pa. — Acoustic waves may be able to control how particles sort themselves. While researchers have been able to separate particles based on their shape — for example, bacteria from other cells — for years, the ability to control their movement has remained a largely unsolved problem, until now. Using ultrasound technology and a nozzle, Penn State researchers have separated, controlled and ejected different particles based on their shape and various properties.  

They published their results in the journal Small.

“We engineered a microchannel nozzle and applied ultrasound energy to the system,” said corresponding author Igor Aronson, the Penn State Dorothy Foehr Huck and J. Lloyd Huck Chair Professor of Biomedical Engineering and professor of chemistry and of mathematics. “The nozzle plays two roles. It concentrates fluid flow, which is something other researchers have done. But in addition to that, the walls of the nozzle reflect the acoustic waves of the ultrasound energy.”

Aronson and his collaborators worked with tiny materials called nanorods, which are some of the most studied synthetic self-propelled particles, according to Aronson. Because they are a similar size and have a similar swimming speed to bacteria, Aronson said, many of the conclusions drawn from observing nanorods can be applied to bacteria movement. For this reason, they are often used as proof of concept for future separation tasks.

In this case, the nanorods were half platinum and half gold. The researchers placed the nanorods in a nozzle, shaped like a miniature syringe, and then added hydrogen peroxide. The hydrogen peroxide is decomposed — or burned — on the platinum half of each nanorod, forcing them to swim in an imitation of how bacteria behave. 

The researchers applied ultrasound to the nozzle, producing acoustic waves that, along with the flow of fluid, were able to separate the nanorod particles, aggregate them or extrude them from the nozzle. 

"The separation concept relies on the fact that nanorods and spherical particles have different responses to acoustic radiation and generated fluid flow,” Aronson said. “By controlling the nozzle shape and the frequency and amplitude of the acoustic radiation, we can coerce particles of different shapes and material properties to behave differently. This, especially, applies to active particles such as nanorods: They can swim autonomously, and their control is especially challenging.” 

This level of control in separating out particles had not been demonstrated previously, according to the researchers.

Aronson said this demonstration has implications for future technologies, including additive manufacturing, also known as 3D printing, and drug delivery.

“For 3D printing, the idea is you can add certain additives to the ink — for example, nanorods,” he said. “So now, we could separate nanorods from spherical particles to deposit only some in the printout, such as depositing polymers without nanorods and so on, all to change the property of the printout.”

Aronson said this principle also applies to printing living cells, known as bioprinting.

“Potential bioprinting applications may include designing acoustic nozzles for bio-inkjet-like printers,” he said. “By controlling the acoustic radiation in the nozzle, we can potentially extrude certain types of cells — for example, stem cells — and trap other types — for example, bacteria. It’s an additional control for bioprints.”

This capability could also be useful for separating bacteria from cells in targeted drug delivery, Aronson said. The researchers next plan to mix live bacteria and cells in a lab setting and then separate and control them. 

The paper’s other authors are Leonardo Dominguez Rubio, a graduate student in the Penn State Department of Biomedical Engineering; Ayusman Sen, the Verne M. Willaman Professor of Chemistry at Penn State; and Matthew Collins, who was a Penn State chemistry graduate student at the time of this work.

The U.S. Department of Energy supported this work.  

The more stakeholders are included in policy planning, the better those policies protect them


Researchers pored over 108 groundwater management plans in California, finding those that incorporated stakeholder input offered greater protection from groundwater depletion


Peer-Reviewed Publication

UNIVERSITY OF CALIFORNIA - SANTA BARBARA



Having a seat at the table, and voices heard, makes a world of difference when it comes to natural resources. It sounds intuitive, but experts didn’t have enough data to prove it until now.

A team of researchers from across the country pored over 108 groundwater management plans in California to see how well they protect stakeholders like domestic well users, farmers and ecosystems. They found that the plans that incorporated stakeholder input offered greater protection from groundwater depletion. Unfortunately, only 9% of the sustainability plans integrated these users in a comprehensive manner.

The findings have broad implications for resource management, both in California and abroad. The authors published their independent analysis in Nature Communications. The data and findings from this study were shared with different stakeholders and organizations, who have used it to inform policy recommendations.

“It’s a big deal that we found empirical evidence that stakeholder integration leads to better protection,” said co-lead author Debra Perrone, an assistant professor in UC Santa Barbara’s Environmental Studies Program. “There are very few published papers that show this connection empirically.”

“I was pretty stunned,” added co-lead author Courtney Hammond Wagner, formerly a postdoctoral scholar at Stanford University and now at the U.S. Department of Agriculture. “I thought this was going to be a different paper.”

An ambitious aim

By 2014, more than a century of unregulated pumping in California had dried up wells, depleted aquifers and even sunk the ground level in many parts of the state. Meanwhile, the region was gripped by unprecedented drought. In dire straits, California passed the Sustainable Groundwater Management Act (SGMA), the first statewide effort to regulate groundwater resources.

Recognizing the complexity of the task at hand, the new legislation took a decentralized approach to groundwater management. The state tasked newly formed, local groundwater sustainability agencies with bringing their basins into balance within 20 years by reducing pumping or increasing groundwater recharge. Plans also needed to avoid undesirable results such as: 

  • lowering groundwater levels; 
  • losing groundwater storage; 
  • seawater intrusion, 
  • land subsidence; 
  • deteriorating groundwater quality; 
  • and losing streamflow.

If a local agency failed to meet the sustainability targets as set, the State Water Resources Control Board would step in to take the helm.

A bevy of groundwater sustainability plans have come out since SGMA was passed. But because planning is a local process, it wasn’t clear how the effort was adding up overall. To answer this question, co-lead authors Perrone, Wagner and Melissa Rohde worked in collaboration with a forum of NGOs tackling groundwater issues in California. Together, they evaluated how well the sustainability plans integrated and protected stakeholders.

Evaluating impact

The authors surveyed 108 management plans, encompassing more than 160,000 pages of text. They came up with a rubric to evaluate stakeholder integration across three groups: domestic users, agriculture and ecosystems. The authors looked at how informed stakeholders were, how much representation they had, and whether their water needs were integrated into the plans. Most importantly, they examined whether stakeholder input had an impact on the protection of wells and ecosystems in the final plan.

How well a plan protected various stakeholders depended on where it set the aquifer’s minimum thresholds, namely the lowest the water table can dip before potentially causing an undesirable result. Only wells deeper than the minimum threshold are protected by the management plan, and the same is true for plant roots in ecosystems. For the sake of caution, the authors also assumed that any well or ecosystem more than 1.5 miles away from a monitoring well was not protected.

Groundwater users and ecosystems are only protected by a management plan if their wells or roots extend below the minimum threshold the policy established for the underlying aquifer. Otherwise, their access to water can’t be guaranteed.

The study distills years of painstaking analysis. It took an entire summer to train the eight co-authors who combed through the lengthy technical documents, and another year and a half to actually go through the management plans.

“I was disappointed to see how many of the state’s wells and ecosystems are not being protected by SGMA,” said Rohde, an independent environmental consultant who worked at The Nature Conservancy during the study. A mere 9% of plans integrated all three stakeholder groups. The 108 management plans failed to protect 60% of agricultural wells, 63% of domestic wells and 91% of groundwater-dependent ecosystems. What’s more, 40% of the state’s wells and 87% of the state’s groundwater-dependent ecosystems are outside the basins regulated by SGMA.

These shortcomings were especially true for stakeholders with less political and economic power, like small farms and disadvantaged communities, terms that are defined by the state and federal governments. “Economically vulnerable groups were not only less integrated into the planning process, but they were also less protected,” Perrone said.

However, in the few cases where stakeholders were integrated into the planning process, management policies protected their interests rather well. “This suggests that if we can design our policies to more explicitly require stakeholder integration, we can likely get better outcomes for stakeholders,” Perrone explained.

“I did not think we would find a relationship between stakeholder integration and protection,” Wagner added, noting how many variables can affect a policy’s outcome: geography, climate, economics, demographics, etc. “And yet,” she said, “we still saw a strong indication that stakeholder integration was associated with better protection. That blew me away.”

Broad implications

SGMA was designed with adaptation in mind. Legislators knew it wouldn’t be perfect at first, so they built in opportunities to evaluate and improve. This study presents one such evaluation and offers the chance to correct course.

That said, the stakes are high. Farmers and communities are running out of water and ecosystems are in decline. So, if management plans aren’t protecting stakeholders, are they failing?

“SGMA is unfortunately not living up to its fullest intent, in the sense that a large majority of wells and ecosystems are not being protected by these groundwater sustainability plans,” Rohde said. “But, the results are also a reminder of how difficult it can be to fully engage diverse stakeholder groups with different needs and values, especially after a long legacy of groundwater depletion.”

“SGMA is a great example of how discretion is a double-edged sword,” Perrone added. “It offers a lot of flexibility, which is great for local control, but it’s at the cost of concrete guidance.”

“To correct course,” Rohde said, “state and local agencies need to be more intentional about ensuring that everyone is at the table and has the technical and financial resources to integrate their water needs into the plans.”

Sustainability policies are on the rise globally to address some of society’s tough challenges, such as climate change, biodiversity loss and natural resource depletion. “But in order to be successful, these plans must intentionally be inclusive of diverse stakeholder needs, especially those groups that have been disenfranchised or historically marginalized,” Rohde said.

BU study unpacks how medical systems harm the intersex community


One of the first studies to highlight intersex peoples’ perspectives on their own medical care

Peer-Reviewed Publication

BOSTON UNIVERSITY SCHOOL OF MEDICINE





(Boston)— Intersex people’s (people whose sex characteristics do not fit within the strict binary categorizations of male or female) healthcare has received a lot of media attention recently, particularly with the uptick in anti-transgender legislation, which often also targets this community. Discrimination and mistreatment in social and medical settings, largely due to the stigma of not conforming to binary views of sex, results in many intersex individuals experiencing isolation, secrecy and shame, which can have a lasting impact on their mental health.

 

A new study from researchers at Boston University Chobanian & Avedisian School of Medicine highlights the need for a systemic shift in the way healthcare providers view intersex variations.

 

“This is a community that has been greatly harmed by the healthcare system and the false ideas that sex and gender exist as a strict binary. One such example is how many intersex infants and children are subject to non-consensual ‘normalizing’ genital surgeries, which have been shown to cause both physiological and psychological harm,” explains corresponding author Kimberly Zayhowski, MS, CGC, assistant professor of obstetrics and gynecology.

 

The researchers conducted and analyzed 15 interviews with members of the intersex community about their experiences with healthcare providers and perspectives on how their care could be improved. The study points to areas of healthcare where intersex people have experienced medical trauma and highlights the need for healthcare providers to use a trauma-informed approach. In their interviews, intersex people highlighted the need to normalize intersex variations and incorporate comprehensive teachings of intersex history and medical care into medical curricula to relieve the burden placed on patients to be their own medical experts and advocates.

 

According to the researchers, this study challenges the commonly held notion that sex exists as strictly male and female–an idea readily refuted by science but which is all too often defended through misrepresentation or misunderstanding of biology. The study also highlights the importance of bodily autonomy and trauma-informed care, which are frameworks that benefit everyone.

 

“This study has implications for the medical care of anyone with an intersex variation, also called variations of sex characteristics. Sometimes physicians will use the term ‘disorders of sex development’ (DSD) to describe intersex variations, but the intersex community has largely rejected this language because it is pathologizing,” says first author Darius Haghighat, MS, CGC, assistant professor of obstetrics and gynecology at the School.

 

The researchers believe that the study participants have been failed by a medical system that discriminated against, violated and misled them. “Systemic change is paramount to address these disparities, oppose abusive practices, and provide the care that the intersex community deserves,” adds Haghighat.

 

These findings appear online in the journal Social Science and Medicine.

 

Funding for this project was provided by Boston University’s Genetic Counseling Program. 

Flexible, supportive company culture makes for better remote work


Peer-Reviewed Publication

GEORGIA INSTITUTE OF TECHNOLOGY

Heatmap 

IMAGE: FREQUENCY HEATMAP FOR THE MOST POPULAR 30 TERMS IN THE DESIRED AND LESS DESIRED ORGANIZATION REVIEWS. view more 

CREDIT: GEORGIA TECH




The pandemic made remote work the norm for many, but that doesn’t mean it was always a positive experience. Remote work can have many advantages: increased flexibility, inclusivity for parents and people with disabilities, and work-life balance. But it can also cause issues with collaboration, communication, and the overall work environment.

New research from the Georgia Institute of Technology used data from the employee review website Glassdoor to determine what made remote work successful. Companies that catered to employees’ interests, gave employees independence, fostered collaboration, and had flexible policies were most likely to have strong remote workplaces.

“One of the biggest changes during the pandemic for all of us, for better or worse, was remote work,” said Munmun De Choudhury, an associate professor in the School of Interactive Computing. “The motivation for us in this research was to understand what makes some organizations more suitable for remote work and others not. We found that cultural aspects matter the most.”

De Choudhury and her Ph.D. student Mohit Chandra presented the research in the paper, “What Makes Some Workplaces More Favorable to Remote Work? Unpacking Employee Experiences During Covid-19 Via Glassdoor,” at Proceedings of the 15th ACM Web Science Conference.

Data Discovery

Glassdoor made for an ideal dataset because employees can post anonymously, leading to more authentic reviews. Although review sites are known for attracting people with strong views, this bias worked in the researchers’ favor — they were looking for people with strong opinions on company culture.

“We are missing the people who are in the middle, but it also actually works in our favor because we really were interested in those positives and negatives,” De Choudhury said. “We recognize the bias, but at the same time, it was still a pretty good data set for us to know the extremes of how people felt.”

Ultimately, they collected more than 140,000 reviews from current employees at 52 Fortune 500 companies that allowed remote work from March 2019 to March 2021, which overlapped with the Covid-19 pandemic. Some of these companies included Verizon, Walmart, and Salesforce. Their textual analysis mostly focused on the pros and cons section of the Glassdoor reviews.

To analyze the data, the researchers created an algorithmic prediction task to identify which cultural attributes a company had prior to the pandemic would lead to favorable remote work environments. Their model used statistical and deep learning methods and correctly predicted a company’s favorable remote work environment 76% of the time.

Using organizational behavior theory, the researchers divided company culture into 41 different dimensions categorized into seven subgroups: interests, work values, work activities, social skills, job structural characteristics, work styles, and interpersonal relationships.

The Company Culture Curve

Companies with a positive culture for remote work excelled in three main categories:

  • Interests: Companies that empower employees to pursue their own goals, interests, and how they conduct their work were viewed more favorably.
  • Work values: Companies that give their employees freedom to make their own decisions and work in a collaborative environment led to more satisfaction.
  • Structured job characteristics: Companies with flexible remote work and hours were more likely to entice employees.

“We found these keywords in reviews like ‘work-life balance’ or ‘flexible work’ occurring frequently in the pros section of good companies,” Chandra said.

Conversely, companies with toxic cultures frequently failed to promote diversity, equity, and inclusion efforts; made workers feel disrespected; and acted unethically.

Ultimately, the researchers believe these results reflect generational differences in what’s most valuable to employees.

“There are a lot of reports of quiet quitting and the great resignation because millennials or Gen Z value culture a lot, in contrast to previous generations like Baby Boomers, for whom job satisfaction was largely about compensation,” said De Choudhury. “Younger generations might say they’re OK with an average salary if they can have that flexibility in work hours, and that’s what makes these companies more favorable to remote work.”

CITATION: Mohit Chandra and Munmun De Choudhury. 2023. What Makes Some Workplaces More Favorable to Remote Work? Unpacking Employee Experiences During COVID-19 Via Glassdoor. In Proceedings of the 15th ACM Web Science Conference 2023 (WebSci '23). Association for Computing Machinery, New York, NY, USA, 312–323. https://doi.org/10.1145/3578503.3583602

 

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The Georgia Institute of Technology, or Georgia Tech, is one of the top public research universities in the U.S., developing leaders who advance technology and improve the human condition. The Institute offers business, computing, design, engineering, liberal arts, and sciences degrees. Its more than 45,000 undergraduate and graduate students, representing 50 states and more than 148 countries, study at the main campus in Atlanta, at campuses in France and China, and through distance and online learning. As a leading technological university, Georgia Tech is an engine of economic development for Georgia, the Southeast, and the nation, conducting more than $1 billion in research annually for government, industry, and society.

BioOne extends partnership with the Entomological Society of America to preserve and disseminate entomological research spanning 100+ years


ESA eBook Collection is accessible to libraries via the BioOne Digital Library


Business Announcement

BIOONE





WASHINGTON, D.C., June 27, 2023 – A trove of more than 160 eBooks in insect science is now available on the BioOne Digital Library, through an extension of BioOne’s partnership with the Entomological Society of America (ESA).

With the launch of the ESA eBook Collection, BioOne and ESA have partnered to source, digitize, and make fully searchable critical books from ESA’s catalog. Through this collaboration, BioOne and ESA share a commitment to make scientific research more accessible with the preservation of over 100 years of natural history and entomological research that also covers a broad range of subjects including agricultural entomology, pest management, insect ecology, and biodiversity. The ESA eBook Collection may be licensed by institutions under a one-time purchase model directly from BioOne. Essential ESA titles available in digital format for the first time include the Handbook of Small Grain InsectsBees and Crop Pollination - Crises, Crossroads, Conservation, and The Larval Ixodid Ticks of the Eastern United States.

 

“Some of these titles are challenging for libraries to find,” said ESA Director of Publications, Communications, and Marketing Matt Hudson. “Creating the ESA eBook Collection on the BioOne Digital Library allows us to make the comprehensive research in this collection broadly accessible, while sustainably covering the substantial costs of digitizing content.”

 

“We’re proud to partner with ESA on this exciting endeavor,” said BioOne President/CEO Lauren Kane. “This project also represents the power of collaboration among BioOne’s community network to achieve mutually beneficial outcomes. Partners from across our publishing, library, and research community came together in support, and we appreciate the hard work of our platform partner, SPIE, and library sourcing partners at Iowa State University, the William F. Barr Entomological Museum at the University of Idaho, and the University of California, Berkeley.”

 

About BioOne

BioOne is an innovative nonprofit collaborative and the leading content aggregator in the biological, ecological, and environmental sciences. More than 150 global scientific societies and nonprofit publishing organizations include their journals in BioOne’s flagship product, BioOne Complete, for the benefit of 3,500 accessing institutions and millions of researchers worldwide. Since 2001, BioOne has returned more than $68 million in royalty sharing back to its participants, with a commitment to share research more broadly, equitably, and sustainably. For more information visit www.bioonepublishing.org.

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Christine Orr

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christine@bioone.org

About the Entomological Society of America

ESA is the largest organization in the world serving the professional and scientific needs of entomologists and people in related disciplines. Founded in 1889, ESA today has more than 7,000 members affiliated with educational institutions, health agencies, private industry, and government. Headquartered in Annapolis, Maryland, the Society stands ready as a non-partisan scientific and educational resource for all insect-related topics. For more information, visit www.entsoc.org.

Poverty negatively impacts structural wiring in children’s brains, study indicates


Reducing obesity, boosting cognitive enrichment may improve kids’ brain health


Peer-Reviewed Publication

WASHINGTON UNIVERSITY SCHOOL OF MEDICINE




A new study from Washington University School of Medicine in St. Louis suggests that growing up in poverty may influence the wiring of a child’s brain.

The study, published June 27 in JAMA Network Open, indicates a link between both neighborhood and household poverty and the brain’s white matter tracts, which allow for communication between brain regions. White matter plays a critical role in helping the brain process information.

The findings stem from the largest long-term study of brain development and child health conducted in the U.S. — the Adolescent Brain Cognitive Development (ABCD) Study, which was launched by the National Institutes of Health (NIH) in 2015. Washington University is a national leader in studies of the developing brain and is one of 21 study sites around the country participating in the ABCD Study, which is following nearly 12,000 children, beginning at ages 9 to 10, for at least a decade.

“White matter integrity is very important in brain development,” said first author Zhaolong (Adrian) Li, a neuroimaging research technician in the Department of Psychiatry. “For example, weaknesses in white matter are linked to visuospatial and mental health challenges in children. If we can capture how socioeconomic status affects white matter early on in a child’s life, the hope is we can, one day, translate these findings to preventive measures.”

The researchers also found that childhood obesity and lower cognitive function may explain, at least partially, poverty’s influence on white matter differences. Generally, children who grow up in poverty have a higher risk of obesity and score lower on tests of cognitive function than their peers in higher income neighborhoods and households. The latter could be due, in part, to limited access to enriching sensory, social and cognitive stimulation.

“Our finding that obesity and cognitive enrichment may be relevant mediators, if confirmed, would provide strong support for managing healthy weight and encouraging cognitively stimulating activities to support brain health in disadvantaged children,” said Tamara Hershey, PhD, the James S. McDonnell Professor of Cognitive Neuroscience and a professor of psychiatry and of radiology.

The research was conducted in the Neuroimaging Labs Research Center in the university’s Mallinckrodt Institute of Radiology.

White matter, the densely packed nerve fibers deep in the brain, gets its white color from the fatty substance that surrounds nerve fibers. The fatty coating is responsible for the rapid transmission of information along nerve cell tracts. The organization and connectivity between these tracts support learning and proper communication across brain regions. Disruption in these communication pathways has been linked to physical challenges as well as worse mental health outcomes.

The scientists used the publicly available ABCD Study database, through which they were able to model water movement as an indicator of white matter integrity in the brain scans of 8,842 children ages 9 to 11. Just like rocks, pebbles and boulders impact the flow of water in a river, diverse brain cell structures create barriers that hinder water diffusion. The researchers found less directional movement of water molecules in the brains of children living in poverty, signifying structural changes in white matter regions. They also found higher water content in spherical spaces in the brain, which hinted at possible neuroinflammation in children who live in poverty.

A child’s environment is complex, involving both neighborhood and family influences. Disadvantaged neighborhoods suffer disproportionately from unemployment, poverty, and income disparity. Single-parent homes are more common, and residents are typically less educated, earn a lower income, and own less property.

“Our analysis revealed that neighborhood poverty is linked to white matter differences and putative immune cell presence. We found a similar link when looking at household socioeconomic status, taking into account annual income and parental education,” Li said.

“Wealth and income inequality are accelerating in the U.S.,” said co-corresponding author Scott Marek, PhD, an assistant professor of radiology and of psychiatry. “We and others are starting to scratch the surface of how inequality may harm the developing brain and affect mental health outcomes. Our findings emphasize shifting away from the thinking that socioeconomics is a unitary construct. It’s not schools or parenting alone that matter for brain health. It’s likely the collection of many neighborhood and familial life factors.”

Hershey, who directs the Neuroimaging Labs Research Center and is a co-corresponding author, cautioned that the study only looked at one time point. Therefore, it is too soon to know if poverty triggered the brain differences seen in the study, she said. However, the ABCD Study continues to track enrolled children through brain scans and cognitive testing with the potential for future long-term brain development studies in disadvantaged children.

“We hope this work encourages future studies to examine modifiable health risk factors in large and longitudinal samples that would one day translate to intervention,” Hershey said.

STOP THE PRESS

Humans' ancestors survived the asteroid impact that killed the dinosaurs


Peer-Reviewed Publication

UNIVERSITY OF BRISTOL




A Cretaceous origin for placental mammals, the group that includes humans, dogs and bats, has been revealed by in-depth analysis of the fossil record, showing they co-existed with dinosaurs for a short time before the dinosaurs went extinct.

The catastrophic destruction triggered by the asteroid hitting the Earth resulted in the death of all non-avian dinosaurs in an event termed the Cretaceous-Paleogene (K-Pg) mass extinction. Debate has long raged among researchers over whether placental mammals were present alongside the dinosaurs before the mass extinction, or whether they only evolved after the dinosaurs were done away with. Fossils of placental mammals are only found in rocks younger than 66 million years old, which is when the asteroid hit Earth, suggesting that the group evolved after the mass extinction. However, molecular data has long suggested an older age for placental mammals.

In a new paper published in the journal Current Biology, a team of palaeobiologists from the University of Bristol and the University of Fribourg used statistical analysis of the fossil record to determine that placental mammals originated before the mass extinction, meaning they co-existed with dinosaurs for a short time. However, it was only after the asteroid impact that modern lineages of placental mammals began to evolve, suggesting that they were better able to diversify once the dinosaurs were gone.

The researchers collected extensive fossil data from placental mammal groups extending all the way back to the mass extinction 66 million years ago.

Lead author Emily Carlisle of Bristol’s School of Earth Sciences said: “We pulled together thousands of fossils of placental mammals and were able to see the patterns of origination and extinction of the different groups. Based on this, we could estimate when placental mammals evolved.”

Co-author Daniele Silvestro (University of Fribourg) explained: “The model we used estimates origination ages based on when lineages first appear in the fossil record and the pattern of species diversity through time for the lineage. It can also estimate extinction ages based on last appearances when the group is extinct.”

Co-author Professor Phil Donoghue, also from Bristol, added: “By examining both origins and extinctions, we can more clearly see the impact of events such as the K-Pg mass extinction or the Paleocene-Eocene Thermal Maximum (PETM).”

Primates, the group that includes the human lineage, as well as Lagomorpha (rabbits and hares) and Carnivora (dogs and cats) were shown to have evolved just before the K-Pg mass extinction, which means their ancestors were mingling with dinosaurs. After they survived the asteroid impact, placental mammals rapidly diversified, perhaps spurred on by the loss of competition from the dinosaurs.

 

Paper:

‘A timescale for placental mammal diversification based on Bayesian modelling of the fossil record’ by Emily Carlisle, Phil Donoghue et al in Current Biology.