Thursday, July 13, 2023

Ohio train derailment, clean-up resulted in high levels of some gases, study shows


Peer-Reviewed Publication

AMERICAN CHEMICAL SOCIETY




A freight train carrying industrial chemicals derailed near East Palestine, Ohio, in February 2023, and to avoid explosions, authorities conducted a controlled release and burned the cars’ contents. Residents were worried about their health and the environment, so researchers have been assessing the local air quality with stationary and mobile sampling methods. Now, in ACS’ Environmental Science & Technology Letters, they report that some gases, including acrolein, reached levels that could be hazardous.

After the derailment, disaster response teams emptied and burned the cargo. Because the tanker cars carried many volatile compounds, such as vinyl chloride and butyl acrylate, localized air-quality-related evacuation orders were issued. However, after returning to their homes, some residents reported symptoms similar to those that typically result from exposure to hazardous levels of airborne compounds. So, Albert Presto and colleagues wanted to monitor air quality and identify the potential health risks in and around East Palestine.

The researchers downloaded air-quality monitoring data from two U.S. Environmental Protection Agency (EPA) stations at fixed locations. And to map patterns of airborne compounds, they drove a cargo van around the area for two days in late February. Inside the van was a mass spectrometer, which was used to identify a wide array of gases, upwind and downwind of the accident site. Then the team calculated the health risks for the gases that were above average or background levels.

From the EPA data, the team determined that the levels of nine of the 50 gases initially rose above their normal baselines, especially acrolein, a respiratory irritant. If these nine compounds remained at those levels, the ambient air could pose health risks, say the researchers. Yet, through February, the amounts of many pollutants decreased significantly. In fact, vinyl chloride declined to concentrations below long-term limits of health concern. Mobile monitoring detected changes over time and space that the stations could not. For instance, during the day, acrolein and butyl acrylate were up to six times higher near the accident site than background levels, but at night they dropped to the background amount. These results indicate the importance of complementary stationary and mobile air-quality assessment techniques, the researchers say, and both should continue as cleanup activities proceed.

The authors acknowledge funding from a National Institute of Environmental Health Sciences Grant, a National Institute of Environmental Health Sciences Training Grant and the Heinz Endowments.

The paper’s abstract will be available on July 12 at 8 a.m. Eastern time here: http://pubs.acs.org/doi/abs/10.1021/acs.estlett.3c00324

For more of the latest research news, register for our upcoming meeting, ACS Fall 2023. Journalists and public information officers are encouraged to apply for complimentary press registration by completing this form.

The American Chemical Society (ACS) is a nonprofit organization chartered by the U.S. Congress. ACS’ mission is to advance the broader chemistry enterprise and its practitioners for the benefit of Earth and all its people. The Society is a global leader in promoting excellence in science education and providing access to chemistry-related information and research through its multiple research solutions, peer-reviewed journals, scientific conferences, eBooks and weekly news periodical Chemical & Engineering News. ACS journals are among the most cited, most trusted and most read within the scientific literature; however, ACS itself does not conduct chemical research. As a leader in scientific information solutions, its CAS division partners with global innovators to accelerate breakthroughs by curating, connecting and analyzing the world’s scientific knowledge. ACS’ main offices are in Washington, D.C., and Columbus, Ohio.

To automatically receive news releases from the American Chemical Society, contact newsroom@acs.org.

Follow us: Twitter | Facebook | LinkedIn | Instagram

Those who are smarter live longer


Mouse lemurs that perform better in cognitive tests live longer


Peer-Reviewed Publication

DEUTSCHES PRIMATENZENTRUM (DPZ)/GERMAN PRIMATE CENTER

Grey mouse lemur 

IMAGE: COLLARED WITH A SPECIAL LOGGER, WE COLLECT ACTIVITY DATA OF THIS GREY MOUSE LEMUR DURING THE DRY SEASON IN MADAGASCAR. HINWEIS view more 

CREDIT: JOHANNA HENKE-VON-DER-MALSBURG




Cognitive abilities not only vary among different species but also among individuals within the same species. It is expected that smarter individuals live longer, as they are likely to make better decisions, regarding habitat and food selection, predator avoidance, and infant care. To investigate the factors influencing life expectancy of wild gray mouse lemurs, researchers from the German Primate Center conducted a long-term study in Madagascar. They administered four different cognitive tests and two personality tests to 198 animals, while also measuring their weight and tracking their survival over several years. The cognition tests assessed problem-solving (reaching food by manipulating a slider), spatial memory (remembering the location of hidden food), inhibitory control (taking a detour to access food), and causal understanding (retrieving food by pulling a string). The first personality test evaluated exploratory behavior, while the second measured curiosity through the animals’ reactions to unfamiliar objects.

Either being particularly smart or particularly explorative – both strategies can lead to longer life

In the study, individuals that performed better in the cognitive tests exhibited less exploratory behavior compared to poorer performing conspecifics. Conversely, more explorative individuals had higher weights, likely due to their ability to find food more easily. The study also found that animals with better cognitive performance, higher weight, and stronger exploratory behavior tended to have longer lifespans. “These results suggest that being either smart or exhibiting good physical condition and exploratory behavior are likely to be different strategies that can lead to a longer lifespan,” said Claudia Fichtel, first author of the study and a scientist at the German Primate Center. “In future studies, we aim to investigate how cognitive abilities translate into behavioral strategies to find food or mating partner.”

 

Neutering practices for owned UK cats significantly influence feral, stray populations


Well-connected cat subpopulations mean that small changes in neutering pet cats have large effects on ferals and strays, per modelling study


Peer-Reviewed Publication

PLOS

Cat: Empirical modelling of Felis catus population dynamics in the UK 

IMAGE: THE STUDY SUGGESTS THAT CONNECTIVITY BETWEEN CAT SUBPOPULATIONS CAN HAVE A BIG INFLUENCE ON POPULATION DYNAMICS. view more 

CREDIT: CIARAN MCCRICKARD/CATS PROTECTION, CC-BY 4.0 (HTTPS://CREATIVECOMMONS.ORG/LICENSES/BY/4.0/)



A new mathematical model of UK cat populations suggests that neutering of cats that belong to people not only affects the population dynamics of owned cats, but also affects feral, stray, and shelter subpopulations. Jenni McDonald of Cats Protection and co-authors present these findings in the open-access journal PLOS ONE on July 12.

More than ten million cats live as owned pets in UK homes, and hundreds of thousands of additional cats live in shelters or as free-roaming feral or stray cats. Cats may transition from any of these subpopulations to another. However, while many prior studies have investigated cat population dynamics, few have accounted for the connectivity between subpopulations, limiting understanding of how certain factors—such as neutering—within a specific subpopulation might also affect other subpopulations.

To help address that gap, McDonald and co-authors developed a mathematical model of cat population dynamics in the UK that includes all four subpopulations. It draws on real-world data to set parameters relating to several different factors, such as survival rates, fertility rates, seasonal breeding patterns, and rates of transitions between subpopulations. The researchers then used the model to simulate how neutering of female cats, as well as changes in other factors, might affect cat population dynamics.

In the simulations, neutering of female owned cats significantly influenced all subpopulations. Lower rates of neutering of female owned cats led to population booms within the other subpopulations, especially for stray cats. The simulations also showed that, even if neutering rates remain the same, neutering female owned cats at a younger age could decrease population growth rates for all subpopulations.

In the simulations, the factors with the greatest influence on overall cat population growth rate were survival and fertility rates of owned cats. Among the subpopulations, stray cats had the second-highest influence, followed by feral cats, and shelter cats had the least influence.

These findings underscore the importance of considering the interlinked nature of cat subpopulations and could help inform population management efforts. The researchers note that the availability of additional real-world cat data would help improve the accuracy of their model.

The authors add: “We previously had little robust understanding of just how important the links between cat subpopulations are. Our study shows that connectivity between cat subpopulations can have a big influence on population dynamics.”

#####

In your coverage please use this URL to provide access to the freely available article in PLOS ONEhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0287841

Citation: McDonald J, Finka L, Foreman-Worsley R, Skillings E, Hodgson D (2023) : Empirical modelling of Felis catus population dynamics in the UK. PLoS ONE 18(7): e0287841. https://doi.org/10.1371/journal.pone.0287841

Author Countries: UK

Funding: The authors received no specific funding for this work.

 

Slow population declines might be going undetected, while later rates of extinction could increase exponentially


Peer-Reviewed Publication

PLOS




Slow population declines might be going undetected, while later rates of extinction could increase exponentially

###

Article URL:  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0285945

Article Title: The rate of species extinction in declining or fragmented ecological communities

Author Countries: Greece, USA

Funding: The authors received no specific funding for this work.

Surgical and engineering innovations enable unprecedented control over every finger of a bionic hand


Peer-Reviewed Publication

CHALMERS UNIVERSITY OF TECHNOLOGY

Zbinden2023_STM_1 

IMAGE: SCHEMATIC ILLUSTRATION OF THE SURGICAL PROCEDURE RESULTING IN THE CREATION OF ELECTRO-NEUROMUSCULAR CONSTRUCTS USED TO CONTROL THE PROSTHESIS. ELECTRODES AND AN OSSEOINTEGRATED INTERFACE PROVIDE THE ELECTRICAL AND MECHANICAL CONNECTION TO THE PROSTHESIS, RESPECTIVELY. view more 

CREDIT: ZBINDEN ET AL., SCI. TRANS. MED., 2023




Prosthetic limbs are the most common solution to replace a lost extremity. However, they are hard to control and often unreliable with only a couple of movements available. Remnant muscles in the residual limb are the preferred source of control for bionic hands. This is because patients can contract muscles at will, and the electrical activity generated by the contractions can be used to tell the prosthetic hand what to do, for instance, open or close. A major problem at higher amputation levels, such as above the elbow, is that not many muscles remain to command the many robotic joints needed to truly restore the function of an arm and hand.

A multidisciplinary team of surgeons and engineers has circumvented this problem by reconfiguring the residual limb and integrating sensors and a skeletal implant to connect with a prosthesis electrically and mechanically. By dissecting the peripheral nerves and redistributing them to new muscle targets used as biological amplifiers, the bionic prosthesis can now access much more information so the user can command many robotic joints at will (video: youtu.be/h1N-vKku0hg).

The research was led by Professor Max Ortiz Catalan, Founding Director of the Center for Bionics and Pain Research (CBPR) in Sweden, Head of Neural Prosthetics Research at the Bionics Institute in Australia, and Professor of Bionics at Chalmers University of Technology in Sweden. 

“In this article, we show that rewiring nerves to different muscle targets in a distributed and concurrent manner is not only possible but also conducive to improved prosthetic control. A key feature of our work is that we have the possibility to clinically implement more refine surgical procedures and embed sensors in the neuromuscular constructs at the time of the surgery, which we then connect to the electronic system of the prosthesis via an osseointegrated interface. A.I. algorithms take care of the rest.” 

Prosthetic limbs are commonly attached to the body by a socket that compresses the residual limb causing discomfort and is mechanically unstable. An alternative to socket attachment is to use a titanium implant placed within the residual bone which becomes strongly anchored – this is known as osseointegration. Such skeletal attachment allows for comfortable and more efficient mechanical connection of the prosthesis to the body.

“It is rewarding to see that our cutting-edge surgical and engineering innovation can provide such a high level of functionality for an individual with an arm amputation. This achievement is based on over 30 years of gradual development of the concept, in which I am proud to have contributed” comments Dr. Rickard BrÃ¥nemark, research affiliate at MIT, associate professor at Gothenburg University, CEO of Integrum, a leading expert on osseointegration for limb prostheses, who conducted the implantation of the interface.  

The surgery took place at the Sahlgrenska University Hospital, Sweden, where CBPR is located. The neuromuscular reconstruction procedure was conducted by Dr. Paolo Sassu, who also led the first hand transplantation performed in Scandinavia. 

“The incredible journey we have undertaken together with the bionic engineers at CBPR has allowed us to combine new microsurgical techniques with sophisticated implanted electrodes that provide single-finger control of a prosthetic arm as well as sensory feedback. Patients who have suffered from an arm amputation might now see a brighter future”, says Dr. Sassu, who is presently working at the Istituto Ortopedico Rizzoli in Italy. 

The Science Translational Medicine article illustrates how the transferred nerves progressively connected to their new hosting muscles. Once the innervation process had advanced enough, the researchers connected them to the prosthesis so the patient could control every finger of a prosthetic hand as if it would be his own (video: https://youtu.be/FdDdZQg58kc). The researchers also demonstrated how the system respond in activities of the daily life (video: https://youtu.be/yC24WRoGIe8) and are currently in the process of further improving the controllability of the bionic hand.

Multimedia content

All images and videos in this link.

More about the research

The work was conducted by researchers at the Center for Bionics and Pain Research (CBPR), a multidisciplinary collaboration between Chalmers University of TechnologySahlgrenska University Hospital, and the Sahlgrenska Academy at the University of Gothenburg, all in Gothenburg, Sweden; the Bionics Institute in Melbourne, Australia; the Istituto Ortopedico Rizzoli, Bologna, Italy; the Scuola Superiore Sant’Anna, Pisa, Italy; the University of Colorado, Aurora, USA. the Massachusetts Institute of Technology, Cambridge, USA; and the medical device company Integrum AB in Sweden.

The research was financed by the Promobilia Foundation, the IngaBritt and Arne Lundbergs Foundation, and the Swedish Research Council (Vetenskapsrådet).

For more information, please contact:

Prof. Max Ortiz Catalan, Center for Bionis and Pain Research, Sweden, and Bionics Institute, Australia. +46 70 846 10 65, maxortizc@outlook.com 

  

Patient wearing a prosthetic arm directly attached to the skeleton and neuromuscular system, which after surgical reconstruction of his residual limb, allows him to control individual fingers of a bionic hand.

Prof. Max Ortiz-Catalan (left) and Jan Zbinden (right) with the individual implanted with the neuromusculoskeletal interface and surgical reconstruction that allows for all fingers of a bionic hand to be intuitively controlled.

Patient wearing a prosthetic limb in the lab at the Center of Bionics and Pain research.

CREDIT

Chalmers University of Technology/Anna-Lena Lundqvist

 

 

 

Robot team on lunar exploration tour

Peer-Reviewed Publication

ETH ZURICH

Team of legged robots 

IMAGE: A TEAM IS GREATER THAN THE SUM OF ITS PARTS – THE TRIO OF LEGGED ROBOTS DURING A TEST IN A SWISS GRAVEL QUARRY. view more 

CREDIT: ETH ZURICH / TAKAHIRO MIKI




On the Moon, there are raw materials that humanity could one day mine and use. Various space agencies, such as the European Space Agency (ESA), are already planning missions to better explore Earth’s satellite and find minerals. This calls for appropriate exploration vehicles. Swiss researchers led by ETH Zurich are now pursuing the idea of sending not just one solitary rover on an exploration tour, but rather an entire team of vehicles and flying devices that complement each other.

The researchers equipped three ANYmal – a type of legged robot developed at ETH – with a range of measuring and analysis instruments that would potentially make them suitable exploration devices in the future. They tested these robots on various terrains in Switzerland and at the European Space Resources Innovation Centre (ESRIC) in Luxembourg, where, a few months ago, the Swiss team won a European competition for lunar exploration robots together with colleagues from Germany. The competition involved finding and identifying minerals on a test site modelled after the surface of the Moon. In the latest issue of the journal Science Robotics, the scientists describe how they go about exploring an unknown terrain using a team of robots.

Insurance against failure

“Using multiple robots has two advantages,” explains Philip Arm, a doctoral student in the group led by ETH Professor Marco Hutter. “The individual robots can take on specialised tasks and perform them simultaneously. Moreover, thanks to its redundancy, a robot team is able to compensate for a teammate’s failure.” Redundancy in this case means that important measuring equipment is installed on several robots. In other words, redundancy and specialisation are opposing goals. “Getting the benefits of both is a matter of finding the right balance,” Arm says.

The researchers at ETH Zurich and the Universities of Basel, Bern and Zurich solved this problem by equipping two of the legged robots as specialists. One robot was programmed to be particularly good at mapping the terrain and classifying the geology. It used a laser scanner and several cameras – some of them capable of spectral analysis – to gather initial clues about the mineral composition of the rock. The other specialist robot was taught to precisely identify rocks using a Raman spectrometer and a microscopy camera.

The third robot was a generalist: it was able to both map the terrain and identify rocks, which meant that it had a broader range of tasks than the specialists. However, its equipment meant that it could perform these tasks with less precision. “This makes it possible to complete the mission should any one of the robots malfunction,” Arm says.

Combination is key

At the ESRIC and ESA Space Resources Challenge, the jury was particularly impressed that the researchers had built redundancy into their exploration system to make it resilient to potential failures. As a prize, the Swiss scientists and their colleagues from the FZI Research Center for Information Technology in Karlsruhe, were awarded a one-year research contract to further develop this technology. In addition to legged robots, this work will also involve robots with wheels, building on the FZI researchers’ experience with such robots.

“Legged robots like our ANYmal cope well in rocky and steep terrain, for example when it comes to climbing down into a crater,” explains Hendrik Kolvenbach, a senior scientist in Professor Hutter’s group. Robots with wheels are at a disadvantage in these kinds of conditions, but they can move faster on less challenging terrain. For a future mission, it would therefore make sense to combine robots that differ in terms of their mode of locomotion. Flying robots could also be added to the team.

The researchers also plan to make the robots more autonomous. Presently, all data from the robots flows into a control centre, where an operator assigns tasks to the individual robots. In the future, semi-autonomous robots could directly assign certain tasks to each other, with control and intervention options for the operator.

###

Video: https://youtu.be/bqwbQzVrzkQ
(Video: ETH Zurich)
This video is currently unlisted on Youtube. Link not to be published until the embargo expires (12 July 2023 2 p.m. ET)

Ice Age saber-tooth cats and dire wolves suffered from diseased joints


Study finds surprisingly high incidence of osteochondrosis in these extinct predators

Peer-Reviewed Publication

PLOS

Subchondral defects resembling osteochondrosis dissecans in joint surfaces of the extinct saber-toothed cat Smilodon fatalis and dire wolf Aenocyon dirus 

IMAGE: PHOTOGRAPH OF A DIRE WOLF RECONSTRUCTION ON EXHIBIT AT THE LA BREA TAR PITS & MUSEUM. view more 

CREDIT: LA BREA TAR PITS AND MUSEUM & NATURAL HISTORY MUSEUM OF LOS ANGELES COUNTY, CC-BY 4.0 (HTTPS://CREATIVECOMMONS.ORG/LICENSES/BY/4.0/)



Ice Age saber-tooth cats and dire wolves experienced a high incidence of bone disease in their joints, according to a study published July 12, 2023 in the open-access journal PLOS ONE by Hugo Schmökel of Evidensia Academy, Sweden and colleagues.

Osteochondrosis is a developmental bone disease known to affect the joints of vertebrates, including humans and various domesticated species. However, the disease is not documented thoroughly in wild species, and published cases are quite rare. In this study, Schmökel and colleagues identify signs of this disease in fossil limb bones of Ice Age saber-tooth cats (Smilodon fatalis) and dire wolves (Aenocyon dirus) from around 55,000 to 12,000 years ago.

Researchers examined over 1,000 limb bones of saber-tooth cats and over 500 limb bones of dire wolves from the Late Pleistocene La Brea Tar Pits, finding small defects in many bones consistent with a specific manifestation of bone disease called osteochondrosis dissecans (OCD). These defects were mainly seen in shoulder and knee joints, with an incidence as high as 7% of the examined bones, significantly higher than that observed in modern species.

This study is limited to isolated bones from a single fossil locality, so further study on other fossil sites might reveal patterns in the prevalence of this disease, and from there might shed light on aspects of these animals’ lives. It remains unclear, for example, whether these joint problems would have hindered the hunting abilities of these predators. Furthermore, OCD is commonly seen in modern domestic dogs which are highly inbred, so it’s possible that the high incidence of the disease in these fossil animals could be a sign of dwindling populations as these ancient species approached extinction.

The authors add: “This study adds to the growing literature on Smilodon and dire wolf paleopathology, made possible by the unparalleled large sample sizes at the La Brea Tar Pits & Museum. This collaboration between paleontologists and veterinarians confirms that these animals, though they were large predators that lived through tough times and are now extinct, shared common ailments with the cats and dogs in our very homes today.”

Detail from a 1911 illustration of a saber-toothed cat in the La Brea Tar Pits.

CREDIT

Robert Bruce Horsfall & Natural History Museum of Los Angeles County, CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/)

In your coverage please use this URL to provide access to the freely available article in PLOS ONEhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0287656

Citation: Schmökel H, Farrell A, Balisi MF (2023) Subchondral defects resembling osteochondrosis dissecans in joint surfaces of the extinct saber-toothed cat Smilodon fatalis and dire wolf Aenocyon dirus. PLoS ONE 18(7): e0287656. https://doi.org/10.1371/journal.pone.0287656

Author Countries: Sweden, USA

Funding: The authors received no specific funding for this work.