Friday, November 10, 2023

Endangered thick-billed parrots at risk of losing newly identified, unprotected Sierra Madre forest habitats to logging, deforestation, study shows


Researchers say data offers hope for community engagement in recovering species


Peer-Reviewed Publication

SAN DIEGO ZOO WILDLIFE ALLIANCE





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A binational team of scientists, using creativity and innovation, adorned dozens of endangered thick-billed parrots with tiny solar-powered satellite transmitters to track and reveal their winter migratory nesting sites in the remote treetops of the Sierra Madre Occidental ranges. Their research reveals new critical habitat, 80% of which has no formal protection.

In a study published this month in the journal Global Ecology & Conservation, researchers from San Diego Zoo Wildlife Alliance and OrganizaciĆ³n Vida Silvestre A.C. (OVIS) in Mexico were able to track the birds that soar high above the rugged pine forests of Mexico, terrain too difficult for researchers to follow. The research was led by James Sheppard, Ph.D., and SDZWA Recovery Ecology Senior Scientist.

“Until now, it was a mystery where thick-billed parrots overwinter and the sites where they nest along the way, creating a difficult challenge for efforts to conserve this species,” Sheppard said. “We have now identified new, critical habitat and migratory routes for thick-billed parrots as well as steps that need to be taken to protect them.”

The charismatic thick-billed parrot, the only living parrot species native to the United States, once thrived in parts of Arizona and New Mexico in the U.S., south to Venezuela. Due to habitat loss, illegal hunting and predation, an estimated less than 2,000 thick-billed parrots remain in the wild, and only in the pine forests of Mexico.

“Prior to this study, there was only anecdotal evidence to suggest where thick-billed parrots spent their breeding and overwintering seasons,” said Ernesto Enkerlin-Hoeflich, OVIS Director for Science. “Now we can show the birds spend their breeding season mostly in the states of Chihuahua and northern Durango then overwinter in the south-central Sierra Madres, and we can share this information with regulatory agencies and engage them and the conservation community to protect the forests the parrots need to survive.”

The study shows parrots require old-growth forests comprised of mature pine trees that provide nesting hollows and pine nuts for food. Less than 1% of the old-growth forest that once covered the Sierra Madre Occidental remains, Sheppard said.

“Strikingly, less than 20% of the newly identified thick-billed parrot overwintering habitat is protected from the timber industry and common clear-cutting practices,” Sheppard said. “Further, existing networks of protected sites may not be adequate for the parrots’ survival as a changing climate increases the intensity and frequency of forest fires as well as exacerbated pine beetle outbreaks, which can devastate a previously healthy forest. The good news is, we understand what’s needed to save this iconic bird.”

Data collected was the result of a three-year effort that started after Sheppard convinced a technology company to sell SDZWA the supplies that the team used to construct the silver-dollar sized transmitters or “backpacks.”

“They weren’t going to sell us the technology because they didn’t think it was possible to attach GPS transmitters to these strong, boisterous birds,” Sheppard said. “But we convinced them and proved it could be done.”

Since first attaching the solar-powered transmitters, researchers have acquired a dataset of more than 40,000 locations remotely from the tracked parrots, enabling the discovery of a new nesting location as well as their overwintering home ranges, migration paths and stopover sites.  

“Now, with the sustained engagement of local stakeholders, we hope to successfully recover wild populations of thick-billed parrots as well as old-growth forests, and perhaps one day, use this information to reintroduce thick-billed parrots to their former ranges, including in the U.S.,” Sheppard said.

 

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About San Diego Zoo Wildlife Alliance

San Diego Zoo Wildlife Alliance, a nonprofit conservation leader, inspires passion for nature and collaboration for a healthier world. The Alliance supports innovative conservation science through global partnerships. Through wildlife care, science expertise and collaboration, more than 44 endangered species have been reintroduced to native habitats. Annually, the Alliance reaches over 1 billion people, in person at the San Diego Zoo and San Diego Zoo Safari Park, and virtually in 150 countries through media channels, including San Diego Zoo Wildlife Explorers television programming in children’s hospitals in 13 countries. Wildlife Allies—members, donors and guests—make success possible. 

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In many cooperative societies (including our own), helpers assist with the post-natal care of breeders’ young, and may thereby benefit the post-natal development of offspring


Mothers in a wild, cooperatively breeding bird lay larger eggs when they will have more help with nestling care, a strategy that may allow helped mothers to focus maternal investment on the pre-natal phase, to which helpers cannot contribute directly

Peer-Reviewed Publication

PLOS

In many cooperative societies (including our own), helpers assist with the post-natal care of breeders’ young, and may thereby benefit the post-natal development of offspring 

IMAGE: 

COOPERATIVE HELPER WHITE-BROWED SPARROW WEAVERS ASSIST WITH THE POST-NATAL CARE OF BREEDERS’ YOUNG (MALE, DARK BEAK; FEMALE, PINK BEAK). THEY THEREBY BENEFIT THE POST-NATAL DEVELOPMENT OF OFFSPRING AND MAY ALLOW MOTHERS TO FOCUS MATERNAL INVESTMENT ON THE PRE-NATAL PHASE, TO WHICH HELPERS CANNOT CONTRIBUTE DIRECTLY.

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CREDIT: ANDREW J. YOUNG (CC-BY 4.0, HTTPS://CREATIVECOMMONS.ORG/LICENSES/BY/4.0/)



In many cooperative societies (including our own), helpers assist with the post-natal care of breeders’ young, and may thereby benefit the post-natal development of offspring

Mothers in a wild, cooperatively breeding bird lay larger eggs when they will have more help with nestling care, a strategy that may allow helped mothers to focus maternal investment on the pre-natal phase, to which helpers cannot contribute directly

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In your coverage, please use this URL to provide access to the freely available paper in PLOS Biologyhttp://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002356

Article Title: Mothers in a cooperatively breeding bird increase investment per offspring at the pre-natal stage when they will have more help with post-natal care

Author Countries: United Kingdom

Funding: The long-term field study was funded by a BBSRC David Phillips Research Fellowship to A.J.Y. (BB/H022716/1) and P.C.-L. was supported by a BBSRC-funded PhD studentship (BB/M009122/1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

 

Ethical, environmental and political concerns about climate change affect reproductive choices


Peer reviewed | Systematic review | People

Peer-Reviewed Publication

UNIVERSITY COLLEGE LONDON

People are beginning to reconsider their reproductive decisions due to complex concerns about climate change, with many choosing to forego childbearing, or reduce the number of children they have as a result, finds a new study by UCL researchers.


The research, published in PLOS Climate, is the first systematic review to explore how and why climate change-related concerns may be impacting reproductive decision-making.

The team examined 13 studies, involving 10,788 participants, which were conducted between 2012 and 2022, primarily in Global North countries such as the USA, Canada, New Zealand, and various European countries. They found that climate change concerns were typically associated with less positive attitudes towards reproduction and a desire or intent for fewer children or none at all.

Underpinning this finding were four key factors: uncertainty about the future of an unborn child, environmentalist views centred on overpopulation and overconsumption, meeting family subsistence needs, and political sentiments.

The term eco-anxiety has rapidly entered public discourse, describing a range of negative emotional responses including fear, worry, guilt and anger as a response to climate change. In 2018, a nationally representative New York Times survey found that 33% of childfree Americans aged 20-45 cited being “worried about climate change” as a reason for not having children.

Since then, ethical concerns about the quality of life children might have in a climate-changed future have been cited as the primary rationale for individuals choosing to not have children. However, the team behind this new study wanted to understand if there was an evidence base supporting the claims that climate change concerns were causing people to change their childbearing decisions, and if so, whether any other motivating factors, aside from ethical concerns, came into play.

The new analysis found that in 12 out of 13 studies, stronger concerns about climate change were associated with a desire for fewer children, or none at all.

One of the main reasons for this was the individual’s concern for their children in a world affected by climate change. However, the review also highlighted three other factors, with a primary concern being the ecological impact of reproduction, as people feared that having children would contribute to overpopulation and overconsumption in a world with already stretched resources.

To a lesser extent, two studies in Zambia and Ethiopia also found that participants desired fewer children to meet subsistence needs during periods of declining agricultural productivity.

Finally, individuals in another study had political considerations resulting in their decision to not have children – with two participants even reporting their refusal to have children as a method of ‘striking’ until systemic change was enacted.

Interestingly, these final two themes were also raised by some participants as reasons to have a greater number of children. For example, in Zambia, participants were concerned about their ability to support their family without the household labour provided by additional children helping with domestic work, as well as water and food collection.

Lead author, Hope Dillarstone (former MSc student at the UCL Institute for Global Health, said: “Recent media attention has been paid to a growing number of individuals factoring their concerns about climate change into their childbearing plans. However, we were concerned that public discourse may have oversimplified this relationship.

“Our first-of-its-kind study shows that there is a complex and intricate relationship between climate change and reproductive choices, with differences noted both within and between countries across the world.

“Our analysis shows that not only are many people concerned about their child’s welfare growing up in a world of uncertainty, but that they are also considering the impact of having children on the environment, their family’s ability to subsist, and their politics.

“Understanding why some people choose to adjust their reproductive decisions as a result of climate change may prove instrumental for shaping public policy, showing a need for collaboration among policymakers to incorporate local-level environmental concerns within national and international climate change, mental health and sexual and reproductive health policies.”

The team are now calling for more research at the intersection of climate change, mental health, and reproductive decision-making, particularly among highly affected Global South populations where current research is lacking.

 

Photonics team develops high-performance ultrafast lasers that fit on a fingertip


The new advance will enable pocket-sized devices that can perform detailed GPS-free precision navigation, medical imaging, food safety inspection and more


Peer-Reviewed Publication

ADVANCED SCIENCE RESEARCH CENTER, GC/CUNY

ultrafast mode-locked laser on a chip 

IMAGE: 

CHIP SCALE, ULTRAFAST MODE-LOCKED LASER BASED ON NANOPHOTONIC LITHIUM NIOBATE.

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CREDIT: ALIREZA MARANDI




Lasers are essential tools for observing, detecting, and measuring things in the natural world that we can’t see with the naked eye. But the ability to perform these tasks is often restricted by the need to use expensive and large instruments.

In a newly published cover-story paper in the journal Science, researcher Qiushi Guo demonstrates a novel approach for creating high-performance ultrafast lasers on nanophotonic chips. His work centers on miniaturizing mode-lock lasers — a unique laser that emits a train of ultrashort, coherent light pulses in femtosecond intervals, which is an astonishing quadrillionth of a second.

Ultrafast mode-locked lasers are indispensable to unlocking the secrets of the fastest timescales in nature, such as the making or breaking of molecular bonds during chemical reactions, or light propagation in a turbulent medium. The high-speed, pulse-peak intensity and broad-spectrum coverage of mode-locked lasers have also enabled numerous photonics technologies, including optical atomic clocks, biological imaging, and computers that use light to calculate and process data.

Unfortunately, state-of-the-art mode-locked lasers are currently expensive, power-demanding tabletop systems that are limited to laboratory use.

“Our goal is to revolutionize the field of ultrafast photonics by transforming large lab-based systems into chip-sized ones that can be mass produced and field deployed,” said Guo, a faculty member with the CUNY Advance Science Research Center’s Photonics Initiative and a physics professor at the CUNY Graduate Center. “Not only do we want to make things smaller, but we also want to ensure that these ultrafast chip-sized lasers deliver satisfactory performances. For example, we need enough pulse-peak intensity, preferably over 1 Watt, to create meaningful chip-scale systems.”  

Realizing an effective mode-locked laser on a chip is not a straightforward process, however. Guo's research leverages an emerging material platform known as thin-film lithium niobate (TFLN). This material enables very efficient shaping and precise control of laser pulses by applying an external radio frequency electrical signal. In their experiments, Guo’s team uniquely combined the high laser gain of III-V semiconductors and the efficient pulse shaping capability of TFLN nanoscale photonic waveguides to demonstrate a laser that can emit a high output peak power of 0.5 Watt.

Beyond its compact size, the demonstrated mode-locked laser also exhibits many intriguing properties that are beyond reach by conventional ones, offering profound implications for future applications. For example, by adjusting the pump current of the laser, Guo was able to precisely tune the repetition frequencies of out pulses in a very wide range of 200 MHz. By employing the strong reconfigurability of the demonstrated laser, the research team hopes to enable chip-scale, frequency-stabilized comb sources, which are vital for precision sensing.

Guo’s team will need to address additional challenges to realize scalable, integrated, ultrafast photonic systems that can be translated for use in portable and handheld devices, but his lab has overcome a major obstacle with this current demonstration.

“This achievement paves the way for eventually using cell phones to diagnose eye diseases or analyzing food and environments for things like E. coli and dangerous viruses,” Guo said. “It could also enable futuristic chip-scale atomic clocks, which allows navigation when GPS is compromised or unavailable.”

More information, including a copy of the paper, can be found online at the Science press package at https://www.eurekalert.org/press/scipak/.

 

About the Graduate Center of The City University of New York
The CUNY Graduate Center is a leader in public graduate education devoted to enhancing the public good through pioneering research, serious learning, and reasoned debate. The Graduate Center offers ambitious students nearly 50 doctoral and master’s programs of the highest caliber, taught by top faculty from throughout CUNY — the nation’s largest urban public university. Through its nearly 40 centers, institutes, initiatives, and the Advanced Science Research Center, the Graduate Center influences public policy and discourse and shapes innovation. The Graduate Center’s extensive public programs make it a home for culture and conversation.

About the Advanced Science Research Center at the CUNY Graduate Center
The Advanced Science Research Center at the CUNY Graduate Center (CUNY ASRC) is a world-leading center of scientific excellence that elevates STEM inquiry and education at CUNY and beyond. The CUNY ASRC’s research initiatives span five distinctive, but broadly interconnected disciplines: nanoscience, photonics, neuroscience, structural biology, and environmental sciences. The center promotes a collaborative, interdisciplinary research culture where renowned and emerging scientists advance their discoveries using state-of-the-art equipment and cutting-edge core facilities.

 

 

Pesticides, herbicides, fungicides detected in New York state beeswax


Peer-Reviewed Publication

CORNELL UNIVERSITY




An analysis of beeswax in managed honeybee hives in New York found a wide variety of pesticide, herbicide and fungicide residues – exposing current and future generations of bees to long-term toxicity.

The study, published in the Journal of Veterinary Diagnostic Investigation, notes that people may be similarly exposed through contaminated honey, pollen and wax in cosmetics. Though the chemicals found in wax are not beneficial to humans, the small amounts in these products are unlikely to pose a major risk to human health, as compared to their impact on bees.

Bees reuse wax over years, causing chemicals to accumulate, including those that are no longer in use in New York but remain in beeswax.

“Because pesticides can accumulate in wax, it’s important for beekeepers to keep removing old wax every few years and having the bees replace it to make sure the colonies and the bee products remain healthy,” said Karyn Bischoff, associate professor of practice at Cornell University and the study’s lead author.

Toxic residues get into beeswax from nectar and pollen of plants that have been sprayed with pesticides, and from drugs and pesticides that beekeepers apply to hives to improve bee health. Healthy bees are vital to New York’s economy and agriculture: the state’s beekeeping industry generated close to $11 million worth of honey in 2020 and annually generates $300 million in pollination services to agriculture.

Pesticides were found in all 72 managed honeybee colony samples analyzed and researchers tallied up to 34 fungicides, 33 insecticides and 22 herbicides, with each wax sample averaging about 18 residues. Wax sent by commercial beekeepers contained the most residues.

“Commercial beekeepers had the most pesticides, which makes sense because those bees are exposed to a lot of different crops, and farmers may use different pesticides for each,” Bischoff said.

The most common chemicals, found in 86% of samples, were acaricides – a class of insecticides that beekeepers use to protect honeybees from varroa mites. These mites are associated with very high bee losses over winter.

Almost every sample (98.6%) contained piperonyl butoxide, a compound that makes animals, insects and fungi more sensitive to insecticides and fungicides, making them more effective. Systemic insecticides (placed on seeds before planting and spreading to all parts of a plant as it grows), called neonics, were also common in samples.

Understanding which contaminants are impacting domestic honeybees may help researchers better protect other pollinators, including wild bees and other insects, as well as birds and bats, Bischoff said. 

The New York State Environmental Protection Fund and the U.S. Department of Agriculture funded the research.  

For additional information, read this Cornell Chronicle story.

Cornell University has dedicated television and audio studios available for media interviews.

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What human diseases can teach us about the immune system


Jennifer Oyler-Yaniv is using cancer as a model system to understand general principles of the immune system


Peer-Reviewed Publication

HARVARD MEDICAL SCHOOL

How immune cells communicate 

IMAGE: 

A MICROSCOPE IMAGE OF MELANOMA CELLS. THE GREEN T CELL IN THE CENTER HAS BEEN ACTIVATED AND IS PRODUCING INTERFERON-GAMMA (PINK/RED), A SIGNALING MOLECULE NECESSARY FOR CERTAIN CANCER IMMUNOTHERAPIES TO WORK. THE OYLER-YANIV LAB IS STUDYING HOW INTERFERON-GAMMA SPREADS THROUGH DENSE TISSUES IN THE BODY

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CREDIT: OYLER-YANIV LAB




The immune system is a crucial part of our survival, regularly fending off wide-ranging attacks on the body, both internal and external. Unsurprisingly, the elegant defense system that protects us from viruses, bacterial infections, cancer, and other threats is immensely complicated. Each time it mounts a response, it must quickly and carefully orchestrate communication across vast numbers of cells and molecules.

Jennifer Oyler-Yaniv is working to figure out how, exactly, the immune system does this — and when and why it fails. 

“There's always the next question, the next thing we don’t understand. As a scientist, I have full creative freedom to get obsessed with problems,” said Oyler-Yaniv, who is an assistant professor of systems biology in the Blavatnik Institute at HMS.

In an ironic twist, Oyler-Yaniv launched her lab at HMS — which she co-leads with her partner, Alon Oyler-Yaniv — at the height of the COVID-19 pandemic, when immunology was garnering new levels of attention from scientists and the public alike.

Straddling the worlds of immunology and systems biology, the Oyler-Yaniv lab is using cancer as a model system to uncover the basic principles of how cells in the immune system communicate. In a conversation with Harvard Medicine News, Oyler-Yaniv discussed her interest in immunology, her approach to research, and her insights about the immune system and cancer.

HMNews: How would you describe the essence of your work?

Oyler-Yaniv: We’re an immunology lab that asks quantitative questions about the immune system. Broadly, we’re interested in how signaling molecules travel through tissues in the body, and how their behavior changes once they get to the target cells they’re going to act on. Specifically, we study cytokines, which are signaling molecules that enable cells in the immune system to communicate with each other. Cytokines are essential for the immune system to clear pathogens and kill tumors, but they can cause damage to the body when they act on cells not involved in the immune response. Because of that, their spatial dynamics must be very tightly regulated.

Our lab has two big wings. One wing is focused on understanding the biophysical principles that regulate the spread of cytokines through three-dimensional, dense tissues. We want to understand how these cytokines are spatially distributed in tissues, and what factors affect their distribution. We are interested in this topic from a basic immunology perspective, and for its clinical applications to cancer. On the other side, we’re interested in how cytokines change their decision-making when they act on cells, including decisions such as whether to die, proliferate, or become dormant. These decisions have important implications for viral infections and cancer.

HMNews: What sparked your interest in immunology?

Oyler-Yaniv: My interest in immunology took off during grad school. Immunotherapy was becoming a viable treatment option for people with cancer, and I was at Memorial Sloan Cancer Center, where a lot of the pioneering work was being done. We would see these survival curves where people who were very sick with cancer and expected to die enrolled in a clinical trial and ended up responding to immunotherapy. It was an incredibly energizing and exciting time to see what the immune system could do to treat cancer, and being in that environment provided me with a huge momentum to study the immune system. I’m interested in the immune system beyond cancer immunotherapy, but that was the catalyst for what got me so excited about it in the first place.

HMNews: You are an immunologist. Why did you join a systems biology department?

Oyler-Yaniv: As a field, systems biology aspires to extract details to find general principles and repeating patterns. That’s something I’m very interested in. My lab aims to identify broader patterns in the way groups of tissues or molecules behave to understand general principles of the immune system. For example, some of our research focuses on how the cytokine interleukin-2 interacts with immune cells called T cells. We are, of course, interested in the biology of that specific interaction, but we also think that it can be a model system to understand how cells communicate more generally. Ultimately, we hope that finding these general principles that can be applied broadly to different diseases and tissues will allow us to form a more unified view of the immune system.

Being in a systems biology department is helpful because we have the perspective of people who care about finding general principles and we are also able to do a lot of mathematical modeling. We use computational tools like machine learning to analyze very large imaging data sets, including data sets from human tumor specimens. A strength of our lab is analyzing those data sets to understand the spatial relationships between different cell types. We also do a lot of live cell microscopy and experiments with basic mouse models of disease, just like every other immunology lab. I think we are in a hybrid space between systems biology and immunology.

HMNews: Your lab recently published a paper on cytokines in melanoma. What were the central findings?

Oyler-Yaniv: I’ve been interested in the pro-inflammatory cytokine interferon-gamma for a long time. Interferon-gamma is an important cytokine in cancer because it is absolutely essential for certain cancer immunotherapies to work. Yet there have been really conflicting studies in mice and humans about the spatial spread of this cytokine through dense tissues — specifically, how far it can spread through a tumor. Some studies claim that this cytokine is released only to its nearest neighbor, and others claim that it can spread over long distances. We approached this question of spatial spread from a biophysics perspective: We generated dense, three-dimensional tissues in a lab dish that allowed us to have a lot of control over the experimental parameters as we investigated how far this cytokine can travel.

In a previous study, working with interleukin-2 as a model system, we found that the spread of molecules through dense tissue is a competition between diffusion, which spreads them further, and consumption, or uptake of molecules by cells with receptors that bind to them. In the new study, we found this is also true for interferon-gamma in the context of melanoma: We could predict how far interferon-gamma would spread in a tumor based on the amount and distribution of cells producing the cytokine and cells with receptors that bind to it. One of our key conclusions was that the only way you get widespread penetration of interferon-gamma through a tumor is if you have a lot of cells producing it and those cells are evenly distributed throughout the tissue. We think that this information could help refine biomarkers to identify who is likely to respond to immunotherapy. We are interested in applying this framework to understanding drug penetration with the idea that drugs are not too different from cytokines in how they spread through a tumor.

HMNews: When you aren’t in the lab, what else do you spend time on at HMS?

Oyler-Yaniv: I teach a science communication and ideation course to our first-year graduate students, which is one of two required courses. I care a lot about helping students communicate more effectively and helping them acquire confidence in coming up with new ideas. There are a lot of misconceptions in science that an idea just pops into someone’s head, when it’s really a lot of storytelling and putting pieces of data together. Research is a team effort, and coming up with ideas is hard. I think that we can normalize that for students and also help them develop a positive attitude and a mindset that it will get easier with time. This is especially important for students who might not have any scientists in their family, so might not be aware of these misconceptions about how creativity works in science. We can also give students some techniques to actually do it — to learn how to come up with ideas, and how to be original and innovative. These are things that are studied and taught in creative fields, but not really in science, so we want to do that.

Authorship, funding, disclosures

Additional authors on the PNAS paper include Edoardo Centofanti, Chad Wang, Sandhya Iyer, Oleg Krichevsky, and Alon Oyler-Yaniv.

This interview was edited for length and clarity