Tuesday, January 16, 2024

 

Why do we cradle babies in one specific arm?


Peer-Reviewed Publication

NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY

Investigating how parents and children interact 

IMAGE: 

PROFESSOR AUDREY VAN DER MEER HAS SPENT HER ENTIRE CAREER STUDYING INFANT DEVELOPMENT, PARTICULARLY WHEN IT COMES TO BRAIN DEVELOPMENT AND MOVEMENTS. NOW SHE'S TAKING A LOOK AT WHY PARENTS CRADLE THEIR BABIES IN A PARTICULAR SIDE OF THEIR BODY. HERE, WITH MAJA IN THE CROOK OF HER LEFT ARM, VAN DER MEER EXPLAINS SHE IS “EXTREMELY RIGHT-HANDED”. 

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CREDIT: PHOTO: ELIN IVERSEN, NTNU




You probably haven’t ever given it much thought, but almost everyone cradles a baby in one specific arm. The vast majority of people always cradle a baby in the crook of their left arm.

Why is that?

“Researchers have been trying to explain this phenomenon,” says Audrey van der Meer, a professor of neuropsychology at the Norwegian University of Science and Technology (NTNU’s) Department of Psychology.

It is undoubtedly a phenomenon and several studies confirm it; the vast majority of people prefer to cradle a baby in the crook of their left arm. Artists have also noticed this.

“The Virgin Mary is usually depicted cradling baby Jesus in the crook of her left arm,” says Professor van der Meer.

The professor has previously studied the phenomenon and has now investigated it in more detail in a review article that includes the latest empirical data and meta-analyses in the field. This work was published in Infancy, an academic journal.

Three out of four people cradle babies in their weakest arm

When van der Meer and Åsmund Husby worked together a few years ago, Husby was a psychology student. He wrote an experimental bachelor’s thesis on the phenomenon under van der Meer’s supervision.

During that year, Husby was one of 35 undergraduate students who collected cradling data from family and friends, kindergartens, schools and sports clubs. Everyone had to perform the doll test on 20 people, and at least 5 of these had to be left-handed.

They tested 765 people aged 4-86. These people were asked to cradle a doll in the crook of one arm. The researchers found that 567 of these (75 percent) cradled the doll in the crook of their non-dominant arm. They tested the subjects’ handedness using a continuous scale.

Article: Handedness as a major determinant of functional cradling bias (tandfonline.com) https://www.tandfonline.com/doi/full/10.1080/13576500500513565

Heartbeat or hearing?

One theory is that most people cradle a baby to the left so that it can hear their heartbeat better. In almost all people, the heart is located on the left. Can the sound of a beating heart soothe a baby or connect it more closely to an adult?

Or maybe it has something to do with our hearing? Humans often perceive information in the form of sound faster with their left ear than their right. The theory is that most people cradle a baby to the left because we then use our left ear and eye to get information about the baby’s emotional state. Signals from the left are sent to the right hemisphere of the brain, which is specialised for interpreting emotions and faces.

However, perhaps the most intuitive explanation is also the most correct.

Associated with the dominant arm 

A few years ago, van der Meer published an empirical study together with researcher Åsmund Husby. This theory holds that the phenomenon is closely related to the arm we use the most.

“Interestingly, this has not been regarded as an adequate explanation, even though it intuitively seems logical,” says Professor van der Meer.

New findings have strengthened this theory.

“Nine out of 10 people in the world are right-handed. We still believe that this is the best explanation why the vast majority of people cradle babies in the crook of their left, non-dominant arm,” says van der Meer.

We are usually doing something else while holding a baby, not just posing for a picture or showing it off. So, we basically do what is most convenient.

We want our ‘best arm’ free to do other things

Most of us cradle a baby to the left in order to have our right hand free. Generally speaking, it is most natural for left-handed people to cradle a baby in the crook of their right arm.

“It is perhaps interesting to mention that there are many pictures of William, the Prince of Wales, cradling a baby in the crook of his right arm. He is left-handed,” says Professor van der Meer.

However, right-handed Kate, the Princess of Wales, cradles babies in her left arm, like most of us.

This does not mean that van der Meer uses royal preferences as proof of the phenomenon. Instead, she has taken other theories into account and focused on the empirical data, and her conclusion is clear.

“The explanation that we cradle babies in the arm we use the least is also true if other factors are taken into account,” says van der Meer.

However, the phenomenon applies only to babies. As children get bigger and heavier, most people tend to carry them using their dominant and stronger arm.

 

Low fitness in youth increases the risk of cardiometabolic diseases in middle age


Peer-Reviewed Publication

UNIVERSITY OF JYVÄSKYLÄ - JYVÄSKYLÄN YLIOPISTO





An extended follow-up study conducted at the University of Jyväskylä shows that low cardiorespiratory fitness in adolescence is associated with higher risk for cardiovascular and metabolic diseases in middle age. The study provides real-life evidence for the far-reaching consequences of deteriorating fitness in youth. 

The 45-year study combined the same participants’ fitness test data from adolescence (12–19 years) with information on diabetes, hypertension, and coronary heart disease as well as self-measurements of waist circumference from the ages of 37 to 44 and/or 57 to 64 years. The associations of cardiorespiratory, muscular and speed-agility fitness with the health conditions were investigated separately and by combining the diseases and risk factors into a cardiometabolic risk score to indicate the burden of the conditions. 

The results showed that low cardiorespiratory fitness in adolescence was associated with a higher burden of cardiometabolic conditions up to the age of 57 to 64 years. Moreover, in females, low adolescent cardiorespiratory fitness increased the risk of hypertension in middle age, and in males, low speed-agility was associated with increased waist circumference in late middle age. 

“Other common cardiometabolic disease risk factors such as age and body mass index were controlled for in the analyses, so we can conclude that cardiorespiratory fitness is an independent early indicator for cardiometabolic health later in life,” says PhD student Perttu Laakso.  

The findings supplement previous evidence regarding mostly male participants from, for example, a study on the data in the conscription register of the Swedish military. 

“There have been publicly discussed concerns over how the deteriorating fitness of young people will affect the future labor force,” Laakso says. “This study gives us some scientific evidence to support that concern."  

“Unfortunately, there is little sign of this concern being alleviated, given that the cardiorespiratory fitness level among today’s adolescents has been shown to be significantly lower than that of the adolescents examined in this study.” 

Laakso emphasizes that it is necessary to tackle all the barriers to young people’s physical activity, whether that means investing in an environment that encourages physical activity or human resources for organized youth sports. 

“The economic cost of these investments will be far lower than the related healthcare or disability expenses caused by cardiometabolic diseases.” 

Finally, Laakso wants to stress that all is not lost even though a person’s physical fitness in adolescence would not have been ideal: “The evidence shows that exercising at all ages lowers the risk for cardiometabolic diseases.” 

 THE BOSS IS ALWAYS RIGHT

How should boards handle visionary CEOs?


New research offers practical, nuanced strategies for boards overseeing confident leaders

Peer-Reviewed Publication

UNIVERSITY OF TEXAS AT AUSTIN





AUSTIN, Texas — The recent firing and rapid rehiring of Sam Altman, the co-founder and CEO of ChatGPT creator OpenAI, illustrates the delicate dance between visionary CEOs and the boards who oversee them.

Some CEOs — often founders — are fueled by strong convictions about the strategic direction their companies should take. But their boards sometimes don’t share their visions.

When that happens, what is the board’s role in governance? Should it monitor or advise the CEO? Should it back off and approve the CEO’s strategy?

The answer depends on how deeply the CEO is invested in the strategy, says Volker Laux, professor of accounting at Texas McCombs and Randal B. McDonald Chair in Accounting. In new research with co-author Xu Jiang of Duke University, Laux built a model of board/CEO relationships, in which a CEO has a strong belief about the state of the industry and the strategy they've created.

The board, representing shareholders’ interests, gathers information to either confirm the CEO’s plan or recommend a switch. But how much effort the board puts into gathering that information — and whether it uses that data to persuade or overrule the CEO — depends on how strongly the manager believes in their vision, the model shows.

Persuadable CEO. If the CEO is only “mildly overconfident,” says Laux, the board will invest more resources to collect information and give advice. In this scenario, if the information shows the strategy is not the right one, the CEO listens and changes direction.

High-Confidence CEO. Sometimes, the CEO has a higher level of confidence and no longer listens to the board’s advice — even if its information suggests the vision is wrong. In such a situation, the board’s best course is to act as a monitor, with the option of overruling the CEO if the accumulation of information supports a new strategy. The stronger the CEOs belief bias, the less information the board will collect, the model finds.

Very High-Confidence CEO. If the CEO is a visionary who strongly believes in their ideas, the board may decide not to intervene, even if it’s convinced a new direction would better serve shareholders. In this case, the board rubber-stamps the CEO’s strategy, because the CEO will be highly motivated to make it succeed.

“It can actually be optimal to be passive,” says Laux. “You often hear that boards are too passive and rubber-stamp the CEO’s vision or ideas, but our setting shows that in certain situations, it can be the right move.”

The alternative — forcing a visionary CEO to change strategy — could backfire by depleting the CEO’s enthusiasm and derailing the company’s progress. It could ultimately mean replacing the CEO. Both scenarios would be costly to shareholders, as the back-and-forth conflict between Altman and his board demonstrates.

“If the loss of motivation would be substantial, the board won’t insist on a strategy shift,” Laux says. “They will just let the CEO run with his idea.”

What Role Do Boards Play in Companies with Visionary CEOs?” is published in Journal of Accounting Research.

Story by Sally Parker

 

Nutritional acquired immunodeficiency (N-AIDS) is the leading driver of the TB pandemic


Acknowledging N-AIDS as a key determinant and comorbidity of TB can enhance the ability to detect, prevent and eliminate TB


Peer-Reviewed Publication

BOSTON UNIVERSITY SCHOOL OF MEDICINE





(Boston)—Tuberculosis (TB) is the leading infectious killer worldwide, with 10.6 million cases and 1.6 million deaths in 2021 alone. One in five incident TB cases were attributable to malnutrition, more than double the number attributed to HIV/AIDS. Like HIV/AIDS, malnutrition is a cause of secondary immunodeficiency, known as nutritionally acquired immunodeficiency syndrome (N-AIDS). However, N-AIDS remains the neglected cousin of HIV/AIDS in global TB elimination efforts.

 

In a review paper led by Madolyn Dauphinais, MPH, researchers at Boston University Chobanian & Avedisian School of Medicine along with collaborators from Cornell University, University of Virginia, and the International Union Against Tuberculosis & Lung Disease, and Jawaharlal Institute of Postgraduate Medical Education and Research, reviewed decades of data and make the case that N-AIDS, just like HIV/AIDS, also deserves special consideration in the effort to eliminate TB.

 

“While there have been important technological advancements to detect and treat TB, our interpretation of the existing literature is that we won’t be able to make substantive changes in TB incidence and mortality rates without action on malnutrition,” explains corresponding author Pranay Sinha, MD, assistant professor of medicine at the school.

 

After reading more than 75 papers on nutrition and TB, the researchers briefly recount the impact that actions on HIV had on the global TB pandemic. They point out that malnutrition is the leading cause of immunodeficiency worldwide. “People with severe malnutrition, like people with HIV, are at increased risk of TB. We can leverage what we already know about malnutrition to aid us in detecting, treating and preventing TB,” says Sinha, who also is an infectious disease physician at Boston Medical Center.

 

While the researchers believe it is urgent to continue to develop newer tools, approaches should not be limited to the biomedical realm. For example, a study included in their review found that TB incidence among household contacts of persons with tuberculosis was reduced by 40% by providing them with an inexpensive food basket. “It is important for the lay audience to understand that TB is not simply a medical disease, it’s a social one and our elimination efforts must recognize that,” he adds.

 

According to the researchers, action on malnutrition will have several benefits beyond TB as well. Throughout their paper, they explore the idea of leveraging nutritional interventions to detect, prevent, and treat TB more effectively. They believe this paper will help advocates, clinicians, policymakers and voters think differently about the management of persons with TB as well as the needed global health investments to eradicate it.  

This paper appears online in BMC Global & Public Health.

 

 

Neuroscientists identify 'chemical imprint of desire'


Study shows dopamine is critical for keeping love alive


Peer-Reviewed Publication

UNIVERSITY OF COLORADO AT BOULDER

Zoe Donaldson 

IMAGE: 

ZOE DONALDSON, ASSOCIATE PROFESSOSR OF NEUROSCIENCE AT THE UNIVERSITY OF COLORADO BOULDER

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CREDIT: CU BOULDER





Hop in the car to meet your lover for dinner and a flood of dopamine— the same hormone underlying cravings for sugar, nicotine and cocaine — likely infuses your brain’s reward center, motivating you to brave the traffic to keep that unique bond alive. But if that dinner is with a mere work acquaintance, that flood might look more like a trickle, suggests new research by University of Colorado Boulder neuroscientists.

“What we have found, essentially, is a biological signature of desire that helps us explain why we want to be with some people more than other people,” said senior author Zoe Donaldson, associate professor of behavioral neuroscience at CU Boulder.

The study, published Jan. 12 in the journal Current Biology, centers around prairie voles, which have the distinction of being among the 3% to 5% of mammals that form monogamous pair bonds.

Like humans, these fuzzy, wide-eyed rodents tend to couple up long-term, share a home, raise offspring together, and experience something akin to grief when they lose their partner.

By studying them, Donaldson seeks to gain new insight into what goes on inside the human brain to make intimate relationships possible and how we get over it, neurochemically speaking, when those bonds are severed.

The new study gets at both questions, showing for the first time that the neurotransmitter dopamine plays a critical role in keeping love alive.

“As humans, our entire social world is basically defined by different degrees of selective desire to interact with different people, whether it’s your romantic partner or your close friends,” said Donaldson. “This research suggests that certain people leave a unique chemical imprint on our brain that drives us to maintain these bonds over time.”

How love lights up the brain

For the study, Donaldson and her colleagues used state-of-the art neuroimaging technology to measure, in real time, what happens in the brain as a vole tries to get to its partner. In one scenario, the vole had to press a lever to open a door to the room where her partner was. In another, she had to climb over a fence for that reunion.

Meanwhile a tiny fiber-optic sensor tracked activity, millisecond by millisecond, in the animal’s nucleus accumbens, a brain region responsible for motivating humans to seek rewarding things, from water and food to drugs of abuse. (Human neuroimaging studies have shown it is the nucleus accumbens that lights up when we hold our partner’s hand).

Each time the sensor detects a spurt of dopamine, it “lights up like a glow stick,” explained first-author Anne Pierce, who worked on the study as a graduate student in Donaldson’s lab. When the voles pushed the lever or climbed over the wall to see their life partner, the fiber “lit up like a rave,” she said. And the party continued as they snuggled and sniffed one another.

In contrast, when a random vole is on the other side of that door or wall, the glow stick dims.

“This suggests that not only is dopamine really important for motivating us to seek out our partner, but there’s actually more dopamine coursing through our reward center when we are with our partner than when we are with a stranger,” said Pierce.

Hope for the heartbroken

In another experiment, the vole couple was kept apart for four weeks—an eternity in the life of a rodent — and long enough for voles in the wild to find another partner.

When reunited, they remembered one another, but their signature dopamine surge had almost vanished. In essence, that fingerprint of desire was gone. As far as their brains were concerned, their former partner was indistinguishable from any other vole.

“We think of this as sort of a reset within the brain that allows the animal to now go on and potentially form a new bond,” Donaldson said.

This could be good news for humans who have undergone a painful break-up, or even lost a spouse, suggesting that the brain has an inherent mechanism to protect us from endless unrequited love.

The authors stress that more research is necessary to determine how well results in voles translate to their bigger-brained, two-legged counterparts. But they believe their work could ultimately have important implications for people who either have trouble forming close relationships or those who struggle to get over loss – a condition known as Prolonged Grief Disorder.

“The hope is that by understanding what healthy bonds look like within the brain, we can begin to identify new therapies to help the many people with mental illnesses that affect their social world,” said Donaldson.

 

 

Building trust and saving lives: A community approach to genetic education


Medical University of South Carolina researchers have developed a training curriculum for community health workers to improve cancer genetic screening among Black women


Peer-Reviewed Publication

MEDICAL UNIVERSITY OF SOUTH CAROLINA

MUSC Hollings Cancer Center researcher Dr. Caitlin Allen 

IMAGE: 

CATILIN ALLEN, PH.D., OF MUSC HOLLINGS CANCER CENTER

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CREDIT: MEDICAL UNIVERSITY OF SOUTH CAROLINA. PHOTOGRAPH BY SARAH PACK.




Changes to DNA, known as mutations, can increase the likelihood of developing cancer. Specifically, people with mutations in their BRCA 1 and 2 genes are substantially more likely to develop hereditary breast and ovarian cancers. But how do people know if they have these mutations?

Genetic testing.

Genetic testing allows doctors to see these microscopic changes. Knowing these mutations exist, doctors will check for signs of breast and ovarian cancers more often.

Yet minorities, especially Black women, are less likely to participate in genetic testing. Even fewer engage in follow-up services, such as recommended interventions, which reduce risk.

To change that, a team of researchers at the Medical University of South Carolina led by Caitlin G. Allen, Ph.D., plans to teach community health workers (CHWs), who often reside in the communities they serve, how to share the importance of genetic screening with their peers. Allen is an assistant professor in the Department of Public Health Sciences at MUSC.

“Community health workers act as a bridge between the community and researchers and clinicians and can help to answer questions, provide support services and address a lot of social determinants of health issues,” said Allen, who has spent more than a decade working alongside and providing support for CHWs.

As a first step, the team worked with CHWs to learn about their needs and preferences for genetics training materials. They describe these efforts in a November article in the Journal of Cancer Education.

Knowing that some minority communities don’t trust researchers and medical staff, Allen and her team recruited CHWs because they are already trusted members of the community. The researchers found that CHWs were already very curious about genetics and eager to learn more.

“There was significant interest from CHWs to learn more about cancer and genetics, but the training to support them in building these competencies and genetic literacy didn’t exist,” explained Allen.

With funding from the American Cancer Society and MUSC Hollings Cancer Center, Allen and her team were able to create this training by holding focus groups with CHWs and doctors, asking them to come to an agreement about which lessons should be included. Once the training materials were developed, the CHWs told the researchers whether they were clear and easy to understand.

Incorporating feedback from these focus groups, Allen and her team finalized their 10-module CHW training called Keeping Each other Engaged Program via IT (KEEP IT). The researchers virtually delivered the 12-hour training to 26 CHWs. The training was effective in improving genetic knowledge and competencies and highly rated by the CHWs. The full outcomes of the KEEP IT training sessions will be published soon.

“It was a privilege to take the idea of CHWs teaching their communities about genetics and put it into action,” said Allen.

But the researchers are far from being finished. They are applying for funding so they can expand the training across four other Southern states.

“Designing and delivering trainings in collaboration with community members is really effective,” stressed Allen, “and it’s important to have community perspective across all research.”

# # #

About  MUSC Hollings Cancer Center 

MUSC Hollings Cancer Center is South Carolina’s only National Cancer Institute-designated cancer center with the largest academic-based cancer research program in the state. The cancer center comprises more than 130 faculty cancer scientists and 20 academic departments. It has an annual research funding portfolio of more than $44 million and sponsors more than 200 clinical trials across the state. Dedicated to preventing and reducing the cancer burden statewide, the Hollings Office of Community Outreach and Engagement works with community organizations to bring cancer education and prevention information to affected populations. Hollings offers state-of-the-art cancer screening, diagnostic capabilities, therapies and surgical techniques within its multidisciplinary clinics. Hollings specialists include surgeons, medical oncologists, radiation oncologists, radiologists, pathologists, psychologists and other clinical providers equipped to provide the full range of cancer care. For more information, visit hollingscancercenter.musc.edu

JAMA

Trends in cancer mortality disparities between Black and white individuals in the US


JAMA Health Forum

Peer-Reviewed Publication

JAMA NETWORK




About The Study: Although U.S. age-adjusted cancer mortality rates declined significantly between 2000 and 2020, substantial racial and ethnic disparities persisted for many common and preventable cancers, including female breast and male colorectal cancer. Cancer disparities arise from a confluence of factors, including structural racism, medical mistrust, health care access inequities, poor socioenvironmental conditions, aggressive tumor biology, and genetic ancestry.

Authors: Tomi Akinyemiju, Ph.D., M.S., of the Duke University School of Medicine in Durham, North Carolina, is the corresponding author.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamahealthforum.2023.4617)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama-health-forum/fullarticle/10.1001/jamahealthforum.2023.4617?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=011224

About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

Medicaid expansion under the Affordable Care Act and early mortality following lung cancer surgery


JAMA Network Open

Peer-Reviewed Publication

JAMA NETWORK



About The Study: In this study of nearly 15,000 adults with non–small cell lung cancer, Medicaid expansion was associated with declines in 30- and 90-day postoperative mortality following hospital discharge. These findings suggest that Medicaid expansion may be an effective strategy for improving access to care and cancer outcomes in this population. 

Authors: Leticia M. Nogueira, Ph.D., M.P.H., of the American Cancer Society in Atlanta, is the corresponding author. 

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ 

(doi:10.1001/jamanetworkopen.2023.51529)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time 

http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2023.51529?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=011224

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.