Saturday, September 21, 2024

 

GE Vernova Plans to Pull Back on Wind Power Including Large Job Cuts

wind turbine manufacturing
GE Vernova confirmed it was looking to downsize its wind energy operations after recent setbacks (GE)

Published Sep 20, 2024 5:42 PM by The Maritime Executive

 

 

In a potentially critical blow to the development of the wind energy sector, GE Vernova, one of three leading manufacturers of wind turbines, confirmed it is looking at scaling back this portion of its business. The company’s plan would leave only two large Western manufacturers as well as the emerging competition from Chinese companies.

The company confirmed reports that it has made a filing with its European Works Council, which would be the first step toward layoffs for its operations in France. EU labor regulations require the company to notify and involve its unions in any planned reorganization.

The company said it is looking at what it called a “downsizing to transform its offshore business globally into a small, learner, and more profitable business.” The reports say it could involve cutting as many as 900 jobs with a third or more of the cuts reportedly planned for the company’s two facilities in France. The plant in Montoir-de-Bertange which builds nacelles according to reports in the French media could lose more than half its workforce. A second facility in Nantes could be downsized by a third. In total, the reports in France say the company is seeking to cut as many as 360 people.

By management’s own emissions, 2024 has been “a very difficult year” for the wind power segment of the company which was spun out from GE in April 2024 to focus on power, wind, and electrification. Earlier this year the company reported it had decided to shelve a plan to build an 18 MW version of its Haliade-X offshore wind turbines. It said it would instead focus on its 13 and 15 MW units which were called the workhorse of the industry. The retrenchment was cited as the reason New York State canceled three selected projects that planned to use the larger turbines.

The company also suffered a high-profile incident when one of the blades on its turbine at the Vineyard Wind 1 project in Massachusetts fractured sending bits into the ocean. The debris washed up on local beaches leading to more protests over the safety of offshore wind power. GE Vernova later blamed that failure on a manufacturing deviation at its plan in Quebec, Canada. All the blades were being reinspected.

Two failures of blades at the UK’s Dogger Bank wind farm were also for its Haliade turbines. They were blamed on installation problems. 

The failures along with disruptions in the supply chain and higher material costs due to inflation were cited as placing increased pressure on this segment of the company’s business. The supply contracts also have long lead times exposing the company to increased costs.  In September, GE Vernova told investors its wind segment is now expected to generate an approximately $300 million EBITDA loss in the third quarter of 2024 given these costs, despite onshore wind delivering a fifth straight quarter of profitability. The company said it expects the wind segment to be modestly profitable in the fourth quarter.

GE Vernova’s scaling back leaves Siemens Gamesa and Vestas Wind Systems as the two leading Western manufacturers. China’s Mingyang and others are growing competitors seeking to make inroads into the Western market. News however that an offshore wind farm in Germany planned to use Mingyang as its supplier triggered a host of political complaints and reports that the contract would be placed under tight scrutiny. 

At the beginning of September, an offshore project planned for New Jersey known as Leading Light Wind asked regulators for a delay citing supply chain problems. The company said it was having problems securing a provider of turbines after GE Vernova canceled its larger turbines. According to the reports, the New Jersey developer decided not to use Vestas while Siemens Gamesa reportedly told them there would be a significant price increase for the turbines.

GE Vernova in its September update to investors cited incremental strength in its Power and Electrification segments saying that it gave it the confidence to reaffirm its full-year 2024 financial guidance despite the challenges in its Wind segment. The company’s stock price was flat today while it was up nearly eight percent for the week. Since the spinoff from GE in April, the stock price is up more than 87 percent.


SOV Servicing UK's Hornsea Wind Farm Hits and Damages Wind Turbine

wind farm SOV
SOV Wind of Hope allided with one of the turbines while servicing a UK wind farm (Cemre Shipyard)

Published Sep 20, 2024 1:36 PM by The Maritime Executive


One of the modern Service Operations Vessels designed specifically to service offshore wind farms was involved in an incident yesterday, September 19. There were no injuries to the crew and technicians aboard but the vessel struck one of the turbines resulting in damage to both the vessel and the base of the turbine.

The SOV is the Wind of Hope, the second of two SOVs built for French company Louis Dreyfus Armateurs (LDA) by the Cemre Shipyard in Turkey. The vessel is 6,500 gross tons and has a length of 275 feet (84 meters) with accommodations for 90 people. The ship was delivered in July 2021 and like the new generation vessels of the class, has dynamic positioning and safety features including a walk-to-work telescopic motion compensated gangway. 

Few details were provided, but according to LDA, the vessel allided with one of the turbines at 1838 last evening in daylight. The contact caused damage to the starboard side of the vessel above the waterline and the helideck. There was also some damage to the base of the turbine.

The Wind of Hope is operating under charter to Ørsted for the Hornsea offshore wind farm located approximately 75 miles east of Hull and Grimsby, UK in the North Sea. Hornsea 1 has been in operation since 2020 with 174 turbines and is part of the largest offshore wind complex which will ultimately consist of four sections. 

The vessel shows that it had departed the base in Grimsby on September 17. LDA reports there are 26 crew members and 46 specialist personnel on board, none of whom were injured. There was no water ingress, nor pollution reported. The vessel is on its way back to Grimsby for a full assessment of the damage.

Ørsted is reported to have created an exclusion zone around the turbine involved in the incident.


Canadian Port Grows as Staging Point for U.S. Offshore Wind

Argentia Canada
Argentia, a former U.S. naval station, is being repurposed and is using its location to marshal parts for offshore wind (Port of Argentia)

Published Sep 20, 2024 6:43 PM by The Maritime Executive


The Port Argentia in the eastern reaches of Canada’s Newfoundland is using its strategic position and available land to develop a business in staging for U.S. offshore wind farms. Port officials reported they have signed a contract with Denmark’s Scan Global Logistics which is responsible for transporting the wind turbine blades which will be staged in 2024 and 2025 before installation.

“Capitalizing on our place as North America’s first monopile marshaling port, we’re now positioned to further expand our capabilities by securing a contract to store and marshal 220 offshore wind turbine blades,” said Scott Penney, CEO of Port of Argentia. “The addition of wind turbine blades demonstrates our unique storage capacity and adds to our portfolio of offshore wind projects.”

The arrangement with Scan Global Logistics, a global transportation and logistics, will see 220 wind turbine blades arrive via heavy transport vessels at Argentia, beginning this fall and continuing into 2025. The port has entered into a lease and services agreement for marshaling and security services utilizing a 12-hectare bonded yard at Argentia.

Ultimately, vessels will pick up the large constructions and deliver the blades for installation at wind farms off the Eastern Seaboard of the U.S. The name of the project is not revealed due to the sensitive nature of the project which skirts the U.S. Jones Act requirements and demands from U.S. states for the use of union labor and local ports. 

The blades, however, are massive measuring several hundred feet and requiring large storage spaces. It is perfect for the Port of Argentia, which was formerly the site of a U.S. naval base in southeastern Newfoundland. Argentia is being redeveloped into a heavy industrial seaport and seeking opportunities with marine transportation, renewable energy, aquaculture, offshore oil, and mining. 

 

Boskalis vessels began delivering monopiles in 2023 (Argentia)

 

Utilizing its existing infrastructure and vast land assets, the port is making available over 70 hectares of paved runways from the former U.S. naval station, within 6,500 feet of quayside, for the marshaling operation. The first operation began in August 2023, with the arrival of Boskalis’ heavy lift vessels transporting monopiles. The port said it was scheduled to receive and store up to 120 monopiles which would be used for future installation in the U.S.

In 2024, the port also entered into initial agreements with the Port of Hamburg (Germany) as part of the effort to develop a future green hydrogen export business. The governments of Germany and Canada supported the project which calls for the production of green hydrogen in Newfound that would be shipped to Germany as an energy source.

 

Monopiles marshaled at Argentia starting in August 2023 (Argentia)


Gulf of Maine Wind Auction Scheduled as Tribes Seek to Delay Oregon Sale

offshore wind energy
BOEM scheduled its second offshore wind energy auction for October 2024 (BOEM)

Published Sep 16, 2024 2:48 PM by The Maritime Executive

 

The Biden administration continues to move forward aggressively to realize its plans for offshore wind energy generation scheduling the second auction planned for October 2024. The Department of the Interior set October 29 for the first auction of Gulf of Maine areas which would be just two weeks after the scheduled sale on the Oregon coast. A collation of tribes however is trying to delay the Oregon sale.

The Department of the Interior highlights it has conducted five offshore wind lease sales during the Biden administration. This includes the record-setting New York Bight as well as the Central Atlantic, the California coast, and less well-received sales in the Gulf of Mexico. A total of 10 offshore wind farms have won approval with the Bureau of Ocean Energy Management (BOEM) recently highlighting the U.S. had reached approval for more than 15 GW offshore wind energy capacity, halfway to the initial offshore goal. 

The planned sale for the Gulf of Maine would be a critical step as it has the potential for approximately 13 GW of offshore wind energy capacity. The eight areas are on the Outer Continental Shelf off Massachusetts, New Hampshire, and Maine. BOEM highlights it shaved off another 120,000 acres from the original proposal reflecting input from the community of ocean users. The final call area outlined in April 2024 was nearly 10 million acres.

“The upcoming Gulf of Maine offshore wind energy auction reflects our all-of-government approach for reaching the Biden-Harris Administration’s energy goals while combatting the climate crisis,” said BOEM Director Elizabeth Klein. BOEM is moving forward quickly, having just reported on September 8 that it had completed the environmental review for the area.

The Gulf of Maine sale will come just two weeks after the scheduled first offshore sale for the coast of Oregon. BOEM announced at the end of August plans to offer three areas ranging from Coos Bay to Brandon and Brookings, which will total nearly 200,000 acres. They calculate the potential for 3.1 GW of energy from the sites.

The Oregon sale has faced persistent opposition from the communities that argue BOEM is moving too quickly. Oregon as a state is not expected to complete its road map for offshore wind development till 2025.

The Confederated Tribes of the Coos, Lower Umpqua, and Siuslaw Indians filed a lawsuit on September 13 against BOEM seeking to delay the sale.

“The intent of this lawsuit is to stop the October lease sale and force BOEM to do a comprehensive Environmental Impact Statement that honestly looks at the impact that wind energy will have on Coastal resources,” said Tribal Council Chair Brad Kneaper. “Coastal Tribes have repeatedly met with BOEM urging BOEM to take its time to develop wind energy in a way that does not adversely impact Tribes and the resources which they depend upon.”

As part of its five-year strategy, BOEM previously released a schedule for 12 additional offshore wind auctions by 2028. However, at the end of July, BOEM reported it was canceling a planned sale for the Gulf of Mexico. They cited low interest instead proposing moving to an agreement with the sole company that was pursuing the leases.

The Department of the Interior cites the extensive review process used to plan sales. For the Gulf of Maine, they said there were two years of engagement with the information used to shape the Final Sale Notice, which will be published on September 17 in the Federal Register.



 

Cooler heads prevail: New research reveals best way to prevent dogs from overheating




American Veterinary Medical Association
Dr. Cynthia Otto 

image: 

Dr. Cynthia M. Otto, lead researcher and executive director of the Penn Vet Working Dog Center

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Credit: Dr. Cynthia OtFOR MORE INFORMATION





 

(SCHAUMBURG, Illinois) September 19, 2024— As temperatures continue to soar across the country, a simple yet innovative technique could be the key to keeping dogs safe from heat-related illnesses.

 

New research published in the Journal of the American Veterinary Medical Association (JAVMA) reveals that teaching dogs to voluntarily dunk their heads in water is the most effective method for rapidly cooling them down after exercise. The study, conducted by researchers at the Penn Vet Working Dog Center at the University of Pennsylvania, compared various cooling methods and found that voluntary head dunking not only cooled dogs faster than other techniques but also prevented dangerous post-exercise temperature spikes.

 

This method could be a game-changer for dog owners and handlers, especially in situations where access to large quantities of water is limited.

 

This study changes our understanding of cooling methods in the dog,” said Dr. Cynthia M. Otto, lead author of the study and executive director of the Penn Vet Working Dog Center. “During heat stress, blood flow to the head, nose, tongue and ears is increased. Cooling the tissues of the head allows for rapid cooling of the whole body with limited amounts of water. Furthermore, training the dog to participate in the cooling process can enhance not only its safety, but the human animal bond.”

 

The importance of cooling dogs quickly

Heat-related illness is a serious risk for dogs, especially during warm weather when dogs can quickly overheat during activities, putting them at risk of heat injury or heat stroke. The research emphasizes the critical rule of “Cool first, transport second,” which encourages owners to begin cooling dogs immediately if they show signs of heat stress, before seeking veterinary care.

 

Among the methods tested, only the voluntary head dunking technique, where dogs are trained to dip their heads into water, prevented dangerous post-exercise temperature spikes, while also cooling dogs faster than the other methods.

 

Simple technique, big benefits

As described in the research, voluntary head dunking uses positive reinforcement training to encourage and reward dogs for submerging their heads in a bucket of water to retrieve a toy or treat. Clean room temperature water is added stepwise until the dog is comfortable immersing its head to retrieve the toy or treat.

 

By teaching dogs to perform this task, owners can help their pets flush their noses and eyes of dust and debris while also providing quick relief from overheating. The research found that dogs trained in this technique could cool down more rapidly after exercise compared to other cooling methods. Additionally, the head dunking can help clear debris from a dog's nose and eyes, making it a versatile first-aid tool.

 

The researchers recommend training dogs in this technique, as it could serve as a valuable skill in the event of heat stress, especially during outdoor activities like hiking or running. It's important to note that training may take anywhere from a few days to several weeks, depending on the individual dog's comfort level and motivation.

 

Practical application for dog owners

As summer continues and many pet owners enjoy outdoor activities with their dogs, these studies provide timely and relevant information for pet owners. Whether for canine athletes, working dogs, or pets enjoying a day at the park, the head dunking method offers a simple way to manage heat stress.

 

To learn more about these cooling methods and the cooperative care training involved, dog owners should consult with their veterinarians and consider incorporating these techniques into their pets’ routines.

 

To view the study, visit https://doi.org/10.2460/javma.24.06.0368. In addition, an accompanying tutorial video is available at https://doi.org/10.2460/javma.24.07.0480.

 

Additional hot weather safety tips for pet owners

Pet owners should be aware that if it's hot outside for humans, it's likely even hotter for pets. There's no set temperature where heat becomes dangerous, as risk can vary based on a pet's physical characteristics, age, weight, underlying medical conditions and activity level. In general, pets with longer or darker fur, flat-faced breeds, older pets, obese pets, or those with certain medical conditions may be at increased risk of heat-related illness.

 

It's crucial for pet owners to recognize the signs of heat stress or heat stroke in their animals. These can include:

  • Anxiousness
  • Elongated tongue
  • Flattened, retracted ears
  • Narrowed eyes
  • Shade seeking
  • Excessive panting where the molars are easily visible and drooling – especially thick ropey saliva
  • Vomiting or diarrhea (sign of more serious heat injury)
  • Abnormal gum and tongue color (dark red)
  • Unsteadiness/collapse (collapse is indication of an emergency)

 

If any of these signs are observed, owners should begin cooling efforts immediately and seek emergency veterinary care.

 

To prevent heat-related issues, pet owners should provide constant access to water and shade for outdoor pets. On particularly hot days, it's best to keep pets indoors or limit outdoor time to early morning or evening hours when temperatures are cooler. Never leave pets alone in vehicles, even for short periods, as temperatures can rise dangerously high within minutes.

 

Additionally, be mindful of hot pavement, which can burn paw pads. Consider using protective booties or walking on grass when possible. By taking these precautions and being aware of their pet's individual needs, owners can help ensure their furry companions stay safe and comfortable during warm weather.

 

Pet owners can learn more about warm weather pet safety at https://www.avma.org/resources/pet-owners/petcare/warm-weather-pet-safety.

 

For more information, contact Michael San Filippo, AVMA senior media relations manager, at 847-732-6194 (cell/text) or msanfilippo@avma.org.

 

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About the AVMA

Serving more than 105,000 member veterinarians, the AVMA is the nation's leading representative of the veterinary profession, dedicated to improving the health and wellbeing of animals, humans and the environment. Founded in 1863 and with members in every U.S. state and territory and more than 60 countries, the AVMA is one of the largest veterinary medical organizations in the world.

 

 

Can captive tigers be part of the effort to save wild populations?



Stanford University




Captive tigers in the United States outnumber those living in the wild. The World Wildlife Federation estimates around 5,000 of the big cats reside in the U.S., mostly owned by private citizens.

The health of this population is a genetic mystery for conservation groups and researchers interested in how the captive tigers could help stabilize or restore wild tiger populations. Are the privately owned animals just like tigers in the wild, or do they reflect characteristics popular in the illegal trade? Are they a hodgepodge of wild tiger ancestry, or are they detrimentally inbred?

New research from Stanford University, published Sept. 19 in Proceedings of the National Academy of Sciences, digs into these questions and offers a new tool that conservationists and law enforcement can use to protect the animals and prosecute those responsible for their abuse.

“We’re trying to leverage genomic technology to be useful in a conservation context – there are so few tigers. We won’t get a second chance if they go extinct,” said Ellie Armstrong, PhD ’21, who is lead author of the paper.

An unknown population

The study was led by Armstrong, who conducted the research as part of her doctoral studies in biology, with her co-advisors and co-authors Elizabeth Hadly, the Paul S. and Billie Achilles Professor in Environmental Biology, Emerita, and Dmitri Petrov, the Michelle and Kevin Douglas Professor, both in the School of Humanities and Sciences.

The researchers became interested in studying the genetic diversity of privately held tigers – called “generic” because their sources are unknown – after conducting a study on the genetic impact of the isolation of wild tiger populations.

“We were conducting a large study on wild tiger populations and leveraged these data to address the issue of captive tigers in the United States. It was a bit unbelievable, at first, that you could have a tiger living right next door and not know it,’” said Armstrong, who is now an assistant professor of evolution, ecology, and organismal biology at the University of California, Riverside. “We got connected with Tigers in America, and that’s when we realized that there’s an enormous number of these cats outside of accredited facilities that were bred for animal encounters, performed as circus animals, or were trafficked as exotic pets. But we didn’t have any idea what kind of tiger they were or where they came from.”

A hurdle for the research team was the absence of official data on generic tigers. Shows like Netflix’s 2020 Tiger King and the 2009 documentary The Tiger Next Door helped grow public knowledge of the problem of privately owned tigers, but accessing the animals for research purposes was still a challenge.

“There was so much hearsay associated with this captive population and a lot of it contradicts itself. People said, ‘All of the cats are really inbred,’ or ‘All of the cats are genetically diverse,’” said Armstrong. “We had no idea what to expect and thought that genomic technology could help us answer some of these questions.”

Building a genetic database

Through relationships with sanctuaries that had rescued generic tigers, the team obtained samples and learned about the tigers, including the rescue locations for many animals.

The researchers collected samples from 154 generic tigers and used another 100 available wild tiger samples existing in the National Center for Biotechnology Information (NCBI) database. From their previous work, the team knew that there are six wild subspecies of tigers. With these data, they developed a reference panel for tigers that was used to accurately distinguish individual animals and assign their genetic ancestry. Armstrong compares it to the popular genetic ancestry tests for humans.

“When we do 23andMe, we’re not sequencing the whole genome – we’re sequencing a portion of it that informs us about your health and ancestry,” she said. “That’s what we want to be able to do, but for tigers. It’s difficult and expensive to sequence and analyze a whole genome, especially in a conservation context. The workflow we built allows you to sequence a portion of the genome and get answers about the tiger individual and its ancestry.”

A boon to law enforcement

Knowing a tiger’s ancestry has uses beyond conservation and breeding programs – law enforcement can use it to prosecute.

The Big Cat Public Safety Act went into effect Dec. 20, 2022, ending the private ownership of big cats as pets and placing restrictions on breeding, commerce, possession, and use of certain species, including tigers. (Individuals who owned cats prior to the law passing must register the animals.) Still, the U.S. Fish and Wildlife Service has storerooms full of confiscated tiger pelts, bones, teeth, etc., and cases they are unable to prosecute because they are unable to positively identify the origin and ancestry of the samples. The agency has already requested to work with the researchers.

“We’ll be working with law enforcement to try to apply this in a forensic context to prosecute wildlife crimes like those seen in Tiger King, monitor the populations in the U.S., and track the illegal trade,” Armstrong said. “Materials like teeth and pelts have limited DNA in them, and the reference panel we built here can allow wildlife agencies to determine the ancestry and identity of confiscated samples, even by only sequencing a small portion of the genome. That’s been the most rewarding part of this research – we know that this work mattered and has immediate future applications.”

Putting rumors to rest

As for those wondering, “What are these animals?” the researchers feel they can put this question to rest. The U.S. captive tiger population did not show widespread inbreeding relative to wild tiger populations. Nor did they show that the generic tigers maintain single subspecies ancestry as is true of zoo-bred tigers or tigers in the wild. These generic tigers are a mix of different tiger subspecies. Armstrong and colleagues also show that the non-zoo captive tiger population in the United States does not harbor more genetic diversity than that found in wild populations.

“This absence of unique genetic diversity in captive tigers means that there will be no ‘genetic rescue’ of wild tigers with individuals now in captivity,” Hadly said. “In other words, the genetic diversity of wild tigers is all that evolution has to work with going into the future.”

DNA is the only way to identify a tiger subspecies – there are no distinguishable physical differences in the six recognized subspecies. If the unique evolutionary histories of individual tiger subspecies remain a priority for tiger management, and we can overcome the enormous hurdles of releasing captive animals back into the wild, the reference panel could be used to identify individuals that do not have mixed ancestry.

Said Armstrong, “This technology is usually a ‘for fun’ thing for humans, to find out more about your genetic ancestry, but we can use genomics in a very serious way to help our wildlife populations thrive in the wild and keep them from being exploited.”

Additional Stanford co-authors of this research include former CEHG/NSF postdoctoral fellow Jazlyn A. Mooney, now Gabilan Assistant Professor at the University of Southern California in the Department of Quantitative and Computational Biology; former postdoctoral scholar Katie Solari; professor emeritus of genetics Gregory Barsh; genetics researcher Christopher B. Kaelin; postdoctoral scholar Bernard Y. Kim; doctoral student Victoria Grant; Noah Rosenberg, the Stanford Professor in Population Genetics and Society and professor of biology in the School of Humanities and Sciences; and researcher Tsuya Yokoyama. Hadly is also a member of Stanford Bio-X, a senior fellow at the Stanford Woods Institute for the Environment, and a Howard Hughes Medical Institute professor. Petrov is also a member of Bio-X, the Maternal & Child Health Research Institute, the Stanford Cancer Institute, and the Stanford Woods Institute for the Environment.

Other co-authors of this work are from HudsonAlpha Institute for Biotechnology, the Hebrew University of Jerusalem, Gencove Inc., the San Diego Zoo Wildlife Alliance, and the National Centre for Biological Sciences, India.

This research was funded by a National Science Foundation Graduate Research Fellowship Program.

 

Scientists aim to decode the genetic roots of mental illness on a large scale





International Society for Stem Cell Research
The fluorescence image of iPSC-converted neuron in a culture dish. 

image: 

Researchers join forces in a consortium called SSPsyGene with the joint goal of characterizing the genetic origins of neurodevelopmental and psychiatric disorders (NPD) focusing on 250 selected high-risk genes. In the initial phase of the project, the teams tested 23 NPD risk genes. The resulting stem cell lines will be made available to other researchers worldwide to facilitate research on those risk genes and their contribution to NPD.

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Credit: MiNND group





Neurodevelopmental and psychiatric disorders (NPD) including schizophrenia, bipolar disorder, autism, and depression are detrimental to individuals, their families and society as a whole, and in many cases still lack effective treatments. It’s becoming more and more clear that genetic mutations in certain genes can increase the likelihood of developing NPD, and several hundreds of those “risk genes” have been identified to date, but their role related to NPD remains a mystery. “Very little is known about the basic function of most of these genes, and what we do know often comes from work in cancer cell lines rather than brain cell types,” says David Panchision, Chief of the Developmental and Genomic Neuroscience Research Branch at the National Institute of Mental Health (NIMH), who spearheaded the SSPsyGene program aiming to tackle this challenge. “As such, we still don’t have a clear understanding of how alterations in these genes may work individually or in combination to contribute to neurodevelopmental and psychiatric disorders.”

To get to the bottom of this, the National Institute of Mental Health (NIMH) initiated a consortium called SSPsyGene (sspsygene.ucsc.edu) in 2023, uniting research teams from renowned US universities with the joint goal of characterizing the genetic origins of NPD, focusing on 250 selected high-risk genes. Among the contributors are Jubao Duan, Endeavor Health (formerly NorthShore University Health System) and University of Chicago, USA and Zhiping Pang, Rutgers University, USA with their teams, who developed a method for mutating NPD risk genes in human stem cells at large scale. In the modified cells, a selected NPD risk gene is mutated so that it no longer makes a functional protein. The modified stem cells can subsequently be turned into neurons and other brain cells to model the consequences of risk gene mutations in a simplified, lab-based version of the human brain.  In the initial phase of the project, the teams tested 23 NPD risk genes, reported in work published in a recent article in the journal Stem Cell Reports. The resulting stem cell lines will be made available to other researchers worldwide to facilitate research on those risk genes and their contribution to NPD. In future works, Pang, Duan and the other members of the consortium will join forces to generate mutated stem cell lines for a much larger number of risk genes, with the ultimate goal of understanding the genetic causes for NPD and for generating better treatments. “The hope is that this collaborative work will generate a highly impactful resource for the neuroscience and psychiatric research community,” Panchision says. 

About Stem Cell Reports
Stem Cell Reports is the open access, peer-reviewed journal of the International Society for Stem Cell Research (ISSCR) for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians. X: @StemCellReports

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Zebrafish “taste” oxygen: A breakthrough in respiratory biology




University of Ottawa
Zebrafish “taste” oxygen: A breakthrough in respiratory biology 

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“We've uncovered a fascinating connection between taste and breathing in fish”

Steve Perry

— Emeritus Professor in the department of biology

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Credit: University of Ottawa





A recent study conducted at the University of Ottawa reveals that some fish use their tastebuds to measure oxygen levels in water. Specifically, zebrafish larvae (a freshwater fish that belongs to the minnow family) can taste oxygen levels in the water using the same cells they use to taste their food. Those same cells also function as oxygen sensors, playing a crucial role in regulating the fish’s breathing response to low oxygen conditions. This dual functionality of taste bud cells was previously unknown and challenges our existing understanding of sensory systems in aquatic animals.

"We've uncovered a fascinating connection between taste and breathing in fish," says Steve Perry, an Emeritus Professor in the department of biology at the University of Ottawa. "Our research provides the first direct evidence of oxygen-sensing cells linked to the control of breathing in these animals, and surprisingly, these cells are located within their taste buds."

To arrive at these conclusions, the research team employed innovative techniques, including intracellular calcium imaging in live fish. 

"We observed that these sensory cells are activated by low oxygen levels, or hypoxia," explains co-author Yihang Kevin Pan, a postdoctoral fellow in Professor Perry’s lab. "When we ablated – or removed- these cells, it disrupted the fish's breathing patterns under hypoxic conditions. Conversely, activating the nerves emanating from the taste buds stimulated breathing."

This discovery has far-reaching implications for understanding how fish adapt to changing environmental conditions. It suggests that the ability to "taste" oxygen levels in the water may be a crucial survival mechanism for aquatic organisms, allowing them to detect and respond to potentially dangerous low-oxygen situations quickly.

The research also highlights the remarkable adaptability of sensory systems in nature. "It's a prime example of how the same biological structure can serve multiple function," Pan notes. "In this case, taste buds in addition to the well-known function of sensing taste cues also serve a vital respiratory function."

As we face increasing environmental challenges, including climate change-induced alterations in aquatic ecosystems, understanding how fish perceive and respond to changes in their environment becomes ever more critical. Beyond scientific understanding, this discovery may have practical implications for protecting and cultivating aquatic life.

The study, titled “Developing zebrafish utilize taste-signaling pathways for oxygen chemoreception”, was published in the journal Current Biology. 

 

Killer yeasts may help remedy a craft beer brewing bother



American Society for Microbiology





Highlights:

  • Diastatic yeasts can spoil craft beer through hyperattenuation, which boosts the alcohol content and causes bottles to explode.
  • Killer toxins, which are produced by other yeast strains, hint at a remedy.
  • In a proof-of-concept study, researchers found that killer toxins inhibited up to 95% of diastatic yeasts.
  • More work is needed to fine tune the recipe, but killer yeasts may help brewers remedy potentially contaminated beers.


Washington, D.C. — Sept. 12, 2024 — When diastatic strains of Saccharomyces cerevisiae, or brewer’s yeast, land in the wrong place, they can become a craft beer brewer’s nightmare. Diastatic yeasts are variant strains of yeasts that secrete glucoamylase, an enzyme that can break down dextrins into simple sugars, which can spoil fresh beer by augmenting the alcohol content, changing the flavor and in worst-case scenarios, making bottles explode.

One way to remedy the problem before bottles start to break might be hiding in plain sight. This week in Applied and Environmental Microbiologya group of brewers and microbiologists report the solution to this yeast problem may be other yeasts. The researchers found that proteins called killer toxins, which are produced naturally by many strains of S. cerevisiae, suppress diastatic strains and may help curb the issue.

“If you’ve got a diastatic contamination, most of the time you just throw away the beer, and that’s expensive,” said microbiologist and senior author Paul Rowley, Ph.D., at the University of Idaho. “What we show in the paper is that we can add the killer yeast at the point of contamination. It’s a remediation procedure to prevent the diastatic strains from taking off.”

Diastatic strains of S. cerevisiae play an important role in brewing Belgian-style saison beers, which typically have a higher alcohol content than other styles. The problem arises, Rowley said, when those strains end up in the mix for pale ales and other types and set off a secondary fermentation. Although many breweries have robust surveillance methods to prevent contamination, the strains can slip by.

“If you were to look at these strains on an agar plate, you couldn’t morphologically tell the difference,” he said. The only difference, he said, is that diastatic yeasts have a genetic change that gives them an extra ability to degrade residual starches. “Yeast looks like yeast.”

Large breweries avoid the problem by pasteurizing beer, but the process is expensive, and some small brewers worry that pasteurization changes the taste, said Nicholas Ketchum, a microbiologist who works at the Rhinegeist brewery in Cincinnati, Ohio and co-author on the new study. One of his responsibilities at Rhinegeist is to keep an eye out for diastatic contamination.

The research began a few years ago when Ketchum was teaching an applied microbiology and brewing class at a community college in Cincinnati. As he prepared a lecture on wild yeasts and killer toxins, he realized that those proteins might offer an inexpensive way to remedy diastatic contamination. He ran a few experiments, presented preliminary findings at the World Brewing Congress in 2020, and discussed the work on a beer brewer’s podcast—where the mention of killer yeasts caught Rowley’s attention.  

Researchers in Rowley’s lab—including then-undergraduates Victor Zhong and Ximena Garcia—subjected 34 diastatic strains of yeast to Saccharomyces strains producing 8 known killer toxins. The most effective toxin, K1, prevented the growth of more than 91% of diastatic strains tested.

The next step is to better understand the mechanism, said Ketchum, and find a way to make it broadly useful to craft brewers. “There are more unknowns than there are knowns” about the process, he said. The efficacy of the toxins, for example, seems to depend on the amount of total yeast in the mix, and not just diastatic strains. Rowley is also currently investigating how widespread the problem is among small brewers.

Rowley continues to investigate killer toxins, which haven’t been well studied. “Yeasts are a lot more complicated than we might think,” he said.

 

###

 

The American Society for Microbiology is one of the largest professional societies dedicated to the life sciences and is composed of over 32,000 scientists and health practitioners. ASM's mission is to promote and advance the microbial sciences.

 

ASM advances the microbial sciences through conferences, publications, certifications, educational opportunities and advocacy efforts. It enhances laboratory capacity around the globe through training and resources. It provides a network for scientists in academia, industry and clinical settings. Additionally, ASM promotes a deeper understanding of the microbial sciences to diverse audiences.

 

 

Catalyzing environmental cleanup: A highly active and selective molecular catalyst and electrified membrane



Innovative electrochemical catalyst breaks down trichloroethylene pollutants at unprecedented rate



Tsinghua University Press

Illustrations of CoPc/CNT catalyst (left) and membrane filtration device (right) for TCE breakdown 

image: 

The CoPc/CNT catalyst decomposes TCE with nearly 100% Faradaic efficiency while the filtration device achieves a 95% removal rate in simulated water samples.

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Credit: Hailiang Wang, Yale University




Connecticut, U.S.A -- Some chemicals create environmental problems; others, fortunately, can help clean them up.

 

Chemists from Yale University and their colleagues have developed an electrochemical catalyst and membrane that offers an efficient and sustainable way to treat water contaminated with trichloroethylene (TCE), a common and persistent environmental pollutant. Their findings highlight the potential for advanced electrochemical treatments in environmental remediation and open the door for further innovations in the field.

 

Their results were published in Carbon Future on September 5.

 

TCE is a common industrial solvent or cleaning agent used in refrigerants, dry cleaning, and metal and electronic degreasing. However, TCE’s toxic properties can cause harm to multiple organs and induce cancer. Water contamination by TCE is not uncommon.

 

While bioremediation was one of the first methods used to tackle TCE pollution, it is often slow and generates byproducts that are even more toxic. Chemical remediation is faster and more efficient but often requires strong chemicals and does not completely decompose TCE. Consequently, electrochemical treatment, which uses electrical currents to decompose contaminants, is emerging as a more effective and sustainable solution for TCE remediation.

 

“Electrochemical methods have shown promise for treating water contaminated by chlorinated volatile organic compounds, but efficiently removing and repurposing TCE has been a challenge due to the lack of effective catalysts,” said Hailiang Wang, a professor at Yale University’s Department of Chemistry and Energy Sciences Institute and the lead corresponding author of this study.

 

Responding to this need, the research team developed a catalyst composed of cobalt phthalocyanine (CoPc) molecules mounted on multiwalled carbon nanotubes (CNTs). This catalyst breaks down TCE at record rates, turning it into ethylene and chloride ions with nearly 100% Faradaic efficiency. This means that almost all the electrical current is used to convert TCE into harmless products without generating harmful byproducts, making it promising for practical applications.

 

“The key to our success is the first electron transfer step, which doesn’t involve protons, and the single site nature of our catalyst” said Yuanzuo Gao, a graduate student in Wang’s group and the first author of this study. “These helped us avoid the hydrogen evolution reaction and thereby promote TCE dechlorination.”

 

The hydrogen evolution reaction is a side reaction that consumes electrons that could otherwise be used to break down pollutants, diminishing the current efficiency of the process.

 

To enhance the practical application of this catalyst, the team incorporated CoPc molecules into an electrified membrane made from reduced graphene oxide (rGO), a modified form of graphene known for its strength, lightweight nature and high conductivity. This membrane filtration device achieved 95% removal of TCE from simulated water samples that mimic actual water treatment conditions, marking a significant advancement in the technology’s practical use.

 

This study underscores the potential of advanced electrochemical methods to address complex environmental challenges and drive progress in water treatment and industrial pollution control.

 

“By combining CoPc molecules with CNT and rGO supports, we have created highly selective and active electrocatalysts for the treatment of TCE in water,” Gao said.

 


About Carbon Future

Carbon Future is an open access, peer-reviewed and international interdisciplinary journal, published by Tsinghua University Press and exclusively available via SciOpen. Carbon Future reports carbon-related materials and processes, including catalysis, energy conversion and storage, as well as low carbon emission process and engineering. Carbon Future will publish Research Articles, Reviews, Minireviews, Highlights, Perspectives, and News and Views from all aspects concerned with carbon. Carbon Future will publish articles that focus on, but not limited to, the following areas: carbon-related or -derived materials, carbon-related catalysis and fundamentals, low carbon-related energy conversion and storage, low carbon emission chemical processes.

About SciOpen 

SciOpen is an open access resource of scientific and technical content published by Tsinghua University Press and its publishing partners. SciOpen provides end-to-end services across manuscript submission, peer review, content hosting, analytics, identity management, and expert advice to ensure each journal’s development. By digitalizing the publishing process, SciOpen widens the reach, deepens the impact, and accelerates the exchange of ideas.