Wednesday, October 02, 2024

Trust in US Supreme Court continues to sink



Asked how much they trust the court to act in their best interest, 1 in 3 Americans say ‘not at all’



Annenberg Public Policy Center of the University of Pennsylvania

Trust in the Supreme Court 2005-2024 

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Source: Annenberg Public Policy Center's AIOD Survey in May 2024 and August 2024 and prior Annenberg surveys.

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Credit: Annenberg Public Policy Center




PHILADELPHIA – Driven by political partisanship, public trust in the U.S. Supreme Court has continued a downward slide since the court’s 2022 Dobbs decision overturning the Roe v. Wade ruling that established a constitutional right to abortion, according to a new survey by the Annenberg Public Policy Center (APPC) of the University of Pennsylvania.

More than half of Americans (56%) now disapprove of the Supreme Court, saying they trust it either “a little” or “not at all” to act in the best interest of “people like you,” according to the nationally representative panel survey conducted in July and August 2024.

Support for the court stands at 44%, with 8% expressing “a great deal” of trust, 11% “a lot” of trust, and 25% “a moderate amount” of trust in the court to act in the best interest of people like you. It is the lowest overall level of trust since APPC began surveying the American public on this issue in 2005, when 75% of the public trusted the court.

Highlights

The new survey, conducted among a nationally representative sample of 1,395 adult U.S. citizens, was fielded July 12-August 12, 2024, following the court’s 2023-24 term, which concluded on July 1 with the court’s ruling in the Capitol insurrection case that Donald Trump has immunity from criminal prosecution for official acts he took as president. The same sample of respondents was previously surveyed in May 2024, during the court term.

In August 2024, 44% overall have trust in the Supreme Court, about the same as 45% in May. But the 40-point spread in trust seen in May between Republicans and Democrats widened significantly to 47 points in August, with 71% of Republicans, 41% of independents, and 24% of Democrats having trust in the court to act in their best interest. Download the topline here.

Earlier APPC surveys found that trust in the court plummeted 22 points after the Dobbs decision, from 68% in 2019 to 46% in 2022. The current survey shows that after a modest rebound, trust has continued to slip, hitting 44% in August 2024. It also finds:

  • Growing numbers have no trust in the court: Asked how much, if at all, do you trust the court to act in the best interest of people like you, 1 in 3 people (34%) in August say “not at all,” up from 30% in May. In a 2005 APPC survey, only 7% did “not at all” trust the court, which shows a stunning increase in distrust over the past two decades.
  • Partisan split growing even wider: Over the three-month period from May to August, partisan divisions in views of the court increased significantly. In May, the parties were divided, with Republicans seeing the Supreme Court more favorably, trusting it more, vesting greater legitimacy in it, and being less willing to endorse potential reforms to the court than Democrats and independents. After the court term, the gap separating Republicans from both Democrats and independents grew on each of these dimensions.
  • Favorability drops in key swing states: Since 2021, APPC has reinterviewed the same set of respondents in Michigan, Pennsylvania, and Wisconsin. These data allow us to compare views of the court from 2021, before the court’s Dobbs decision, to today, two years after that landmark ruling. Over that time, we have seen a dramatic decline in the public’s view of the court – mostly from a decrease in support from both Democrats and independents.

“This underscores how Dobbs has fundamentally shifted views of the court,” said University of Pennsylvania political science professor Matthew Levendusky, the Stephen and Mary Baran Chair in the Institutions of Democracy at the Annenberg Public Policy Center and director of the survey. “For many years, the court was held in high esteem by all Americans across partisan lines, but no more – that polarization emerged after Dobbs, and the court’s rulings since then have done little to change these perceptions.”

Partisan differences in attitudes toward the court

For decades, the Supreme Court had been seen as one of the few institutions respected by Republicans and Democrats alike. In a journal article this year, Annenberg Public Policy Center researchers said the court had been primarily regarded as a legal institution, not a political one, strengthened by its “norms, processes, symbols, and independence,” and was therefore afforded greater public trust and legitimacy than other institutions. (See “Has the Supreme Court become just another political branch? Public perceptions of court approval and legitimacy in a post-Dobbs world” in Science Advances.)

A second article this year by APPC researchers found that declining trust in the Supreme Court was mirrored in the federal judiciary, with the percentage of Americans with either “a great deal” or “a fair amount” of trust and confidence in the judicial branch falling to under 50% in 2022 from 75% in 2000. (See “The withering of public confidence in the courts” in Judicature.)

This year, APPC surveyed a nationally representative sample of adult U.S. citizens during and after the most recent Supreme Court term in, respectively, May and August 2024. These national surveys found that:

  • Favorability increased slightly among Republicans but decreased among both independents and Democrats.
  • Trust: Republicans placed greater trust in the court, though trust dropped among Democrats and independents.
  • Reform: Support for a half-dozen proposed reforms to the U.S. Supreme Court, taken as a group, increased among Democrats and independents, but decreased slightly among Republicans. Overall, a majority of the public shows strong support for several potential reforms to the Supreme Court, including prohibiting justices from participating in cases in which they have personal or financial interests (83% support); creation of a formal ethics code that allows justices to be investigated if they are accused of an ethical violation (75% support); a mandatory retirement age (71%) and term limits (68%). In addition, half of those surveyed (50%) support allowing the public to vote to overturn Supreme Court decisions on controversial issues and a third (32%) support increasing the number of justices on the current nine-member court.
    • For further details on support for potential reforms to the court, see our news release issued in early September, based on the May 2024 findings.

Legitimacy: Institutional support for the court

In addition to the three measures of support described above, the APPC surveys also asked a set of questions which tap into deeper institutional support for the U.S. Supreme Court. Respondents were asked whether they agreed or disagreed with the following statements:

  1. If the Supreme Court started making a lot of rulings that most Americans disagreed with, it might be better to do away with the Court altogether.
  2. The U.S. Supreme Court gets too mixed up in politics.
  3. The U.S. Supreme Court ought to be made less independent so that it listens a lot more to what the people want.
  4. The right of the Supreme Court to decide certain types of controversial issues should be reduced.
  5. Justices on the U.S. Supreme Court who consistently make unpopular decisions should be removed from their position as Justice.

In our analysis, conducted by APPC research analyst Shawn Patterson Jr., we use the average of each panelists’ responses to these questions as a measure of institutional legitimacy. While the effects are smaller than for favorability or trust, here, too, we see that Republicans viewed the court as more legitimate than Democrats and independents in May, and that the gap between the parties grew significantly over the following three months

Evidence from three swing states

Surveys conducted in three swing states – Michigan, Pennsylvania, and Wisconsin – bolster these findings. Panelists were asked about their favorability toward the court on six occasions from November 2021 through August 2024. These results show that:

  • Before and after Dobbs, there is a dramatic decline in the public’s view of the court. In 2021, before the decision, the average respondent had a “neither favorable nor unfavorable” view of the court, but post-Dobbs in 2022, that fell 31%, to just more than “somewhat unfavorable” on average and it has remained below pre-Dobbs levels since.
  • This decrease in support for the court comes mostly from changes among Democrats and independents. In 2021, the difference between the two parties was relatively small, with little partisan polarization in views of the court. Today the gap in favorability between the parties has more than doubled, a 101% increase.

About the surveys

The most recent findings are based on two ongoing Annenberg Institutions of Democracy (AIOD) panel studies, surveys that interview the same sets of voters over time. One is a nationally representative sample of adult U.S. citizens, while the other is a sample of adult U.S. citizens living in Michigan, Pennsylvania, and Wisconsin (the sample in each state is drawn to be representative of adults living in that state). Both sets of respondents were interviewed from May 1-23, 2024, and from July 12-August 12, 2024. The swing state samples have also been interviewed roughly quarterly since May 2020.

Data collection for the national panel was conducted from May 1-23, 2024, among a sample of 1,620 adult U.S. citizens, divided in three subgroups. The margin of sampling error (MOE) for the complete set of weighted data is ± 3.3 percentage points at the 95% confidence level. The panel survey was conducted again July 12-August 12, 2024, among a sample of 1,395 U.S. adult citizens, with a margin of error of ± 3.6 percentage points.

Download the topline and methodology here.

For more information on the sampling of the swing state panel, see the Appendix for the book “Democracy Amid Crises,” available at https://osf.io/487jk/.

The battery of survey questions about court reform was developed under the supervision of Matt Levendusky, director of the AIOD national panel at the Annenberg Public Policy Center. The analysis and graphics were prepared by APPC research analyst Shawn Patterson Jr. The team supervising the survey also includes Kathleen Hall Jamieson, the director of APPC, and Ken Winneg, APPC’s managing director of survey research.

The Annenberg Public Policy Center was established in 1993 to educate the public and policy makers about communication’s role in advancing public understanding of political, science, and health issues at the local, state, and federal levels.

 THAT'S DIALECTICS

Do NFTs create value in games? There are at least three ways to look at it




University of Vaasa
Alesha Serada 

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Alesha Serada

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Credit: University of Vaasa



When blockchain is introduced into video gaming, the economy and sometimes the entire design of such games focus on artificial scarcity and ownership of game items. However, this approach overlooks some of the most important aspects of value creation in games, according to Alesha Serada’s research at the University of Vaasa. The value of game items is derived from manifold social relations in gaming communities, in the ways that frequently disregard rarity or price of digital assets.

Alesha Serada's doctoral dissertation demonstrates how the value of Non-Fungible Tokens (NFTs) is constructed in games, using the example of one of the first popular and longest-running blockchain-based games, CryptoKitties. 

The processes of value creation and extraction in games are well familiar to industry practitioners, but they are rarely studied by academic researchers. This continues to be a problem, because consumer awareness is often low, and corporate responsibility in the gaming industry is lacking. Back in 2017, NFTs on blockchain were promised to liberate gamers from corporate greed of major game publishers. As of 2024, this promise is not fulfilled yet.

According to their early adopters, NFTs would ensure property rights in virtual worlds and create new types of value based on unique properties of blockchain technology. After eight years of creative evolution, only very few blockchain-based games have reached a noticeable level of adoption, and even those are critically panned. This indicates the lack of value in such games to their players. 

However, games are one of very few blockchain applications beyond cryptocurrencies that saw at least some level of adoption. So-called ‘crypto games’ made an important contribution to the development of blockchain platforms, as Serada argues in their doctoral dissertation, to be defended on October 4 at the University of Vaasa. 

– I chose CryptoKitties as my primary case for studying value on blockchain, because it was the first of this kind to reach overnight fame, says Serada. – Besides, this is also one of the very few blockchain-based games to have a friendly and vibrant community. Thanks to it, the game managed to survive several ‘crypto winters’ on the cryptocurrency market. Throughout the years, a wealth of quantitative data has been accumulated both on blockchain and off-chain, which I combined with qualitative data from the game community and the game itself.

A holistic model of value creation in games before and after blockchain

Despite the many inefficiencies of blockchain, game designers can learn valuable lessons from blockchain-based games. Based on research, Serada suggests a three-dimensional model that takes into account different types of value: the value as designed by game creators, the subjective value of items projected by an individual player, and the value that is collectively created by the game community. The last type of value is the fundamental and most sustainable way of value creation in games, and yet blockchain-based games are particularly low on it. The dissertation also includes a decision flowchart, which can be used to determine what kind of value, if any, is constructed in a game item represented by an NFT.

Public defence 

The public examination of Master of Sociology Alesha Serada’s doctoral dissertation “Value Creation and Price Negotiation on the Blockchain-Based Marketplace: The Case of CryptoKitties" will be held at the University of Vaasa, in Auditorium Nissi, on Friday October 4, 2023, at noon. It is possible to participate in the defence also online via Zoom, password: 697917

Professor Juho Lindman (University of Gothenburg) will act as an opponent and Professor Tanja Sihvonen as a custos. The defence will be held in English. 

Dissertation

Serada, Alesha (2024) Value Creation and Price Negotiation on the Blockchain-Based Marketplace: The Case of CryptoKitties. Acta Wasaensia 533. Doctoral dissertation. University of Vaasa

Publication PDF https://osuva.uwasa.fi/handle/10024/18000


 

Bottlenose dolphins “smile” at each other while playing




Cell Press
Open mouth smile 

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Open mouth smile

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Credit: ZooMarine, Italy




Dolphins are extremely playful, but little is known about how they—and other marine mammals—communicate during playtime. New research publishing October 2 in the Cell Press journal iScience shows that bottlenose dolphins (Tursiops truncates) use the “open mouth” facial expression—analogous to a smile—to communicate during social play. The dolphins almost always use the facial expression when they are in their playmate’s field of view, and when playmates perceived a “smile,” they responded in kind 33% of the time.

“We’ve uncovered the presence of a distinct facial display, the open mouth, in bottlenose dolphins, and we showed that dolphins are also able to mirror others’ facial expression,” says senior author and evolutionary biologist Elisabetta Palagi (@bettapalagi) of the University of Pisa. “Open-mouth signals and rapid mimicry appear repeatedly across the mammal family tree, which suggests that visual communication has played a crucial role in shaping complex social interactions, not only in dolphins but in many species over time.”

Dolphin play can include acrobatics, surfing, playing with objects, chasing, and playfighting, and it’s important that these activities aren’t misinterpreted as aggression. Other mammals use facial expressions to communicate playfulness, but whether marine mammals also use facial expressions to signal playtime hasn’t been previously explored.

“The open mouth gesture likely evolved from the biting action, breaking down the biting sequence to leave only the ‘intention to bite’ without contact,” says Palagi. “The relaxed open mouth, seen in social carnivores, monkeys’ play faces, and even human laughter, is a universal sign of playfulness, helping animals—and us—signal fun and avoid conflict.”

To investigate whether dolphins visually communicate playfulness, the researchers recorded captive bottlenose dolphins while they were playing in pairs and while they were playing freely with their human trainers.

They showed that dolphins frequently use the open mouth expression when playing with other dolphins, but they don’t seem to use it when playing with humans or when they’re playing by themselves. While only one open mouth event was recorded during solitary play, the researchers recorded a total of 1,288 open mouth events during social play sessions, and 92% of these events occurred during dolphin-dolphin play sessions. Dolphins were also more likely to assume the open mouth expression when their faces were in the field of view of their playmate—89% of recorded open mouth expressions were emitted in this context—and when this “smile” was perceived, the playmate smiled back 33% of the time.

“Some may argue that dolphins are merely mimicking each other’s open mouth expressions by chance, given they’re often involved in the same activity or context, but this doesn’t explain why the probability of mimicking another dolphin’s open mouth within 1 second is 13 times higher when the receiver actually sees the original expression,” says Palagi. “This rate of mimicry in dolphins is consistent with what’s been observed in certain carnivores, such as meerkats and sun bears.”

The researchers didn’t record the dolphins’ acoustic signals during playtime, and they say that future studies should investigate the possible role of vocalizations and tactile signals during playful interactions.

“Future research should dive into eye-tracking to explore how dolphins see their world and utilize acoustic signals in their multimodal communication during play,” says corresponding author and zoologist Livio Favaro (@LivioF_80). “Dolphins have developed one of the most intricate vocal systems in the animal world, but sound can also expose them to predators or eavesdroppers. When dolphins play together, a mix of whistling and visual cues helps them cooperate and achieve goals, a strategy particularly useful during social play when they’re less on guard for predators.”

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iScience, Maglieri et al., “Smiling underwater: exploring playful signals and rapid mimicry in bottlenose dolphins” https://cell.com/iscience/fulltext/S2589-0042(24)02191-6

iScience (@iScience_CP) is an open access journal from Cell Press that provides a platform for original research and interdisciplinary thinking in the life, physical, and earth sciences. The primary criterion for publication in iScience is a significant contribution to a relevant field combined with robust results and underlying methodology. Visit https://www.cell.com/iscience. To receive Cell Press media alerts, contact press@cell.com

Most tropical lightning storms are radioactive



New observations from a retrofitted U2 spy plane reveal a surprising amount and variety of gamma radiation is produced in large tropical thunderstorms



Duke University




DURHAM, N.C. – In the 1990s, NASA satellites built to spot high-energy particles coming from supernovas and other celestial-sized objects discovered a surprise — high energy gamma radiation bursts coming from right here on Earth.

While it didn’t take long for researchers to figure out that these radioactive supercharged particles were coming from thunderstorms, how commonly the phenomenon happened remained a mystery. Satellites weren’t built to find gamma radiation coming from Earth, and they had to be in just the right place at just the right time to do so.

After years of making do with platforms not ideal for the task, a group of scientists secured an opportunity to fly a retrofitted U2 spy plane owned by NASA over storms to take a proper look. In two new papers published October 3 in Nature, the team discovered that gamma radiation produced in thunderstorms is far more common than anyone thought and that the dynamics creating the radiation hold a treasure trove of mysteries yet to be solved.

“There is way more going on in thunderstorms than we ever imagined,” said Steve Cummer, the William H. Younger Distinguished Professor of Engineering at Duke University, who was a coauthor on both papers. “As it turns out, essentially all big thunderstorms generate gamma rays all day long in many different forms.”

The general physics behind how thunderstorms create high-energy flashes of gamma radiation is not a mystery. As thunderstorms develop, swirling drafts drive water droplets, hail and ice into a mixture that creates an electric charge much like rubbing a balloon on your shirt. Positively charged particles end up at the top of the storm while negatively charged particles drop to the bottom, creating an enormous electric field that can be as strong as 100 million AA batteries stacked end-to-end.

When other charged particles — such as electrons — find themselves in such a strong field, they accelerate. If they accelerate to high enough speeds and happen to strike an air molecule, they knock off more high-energy electrons. The process cascades until the collisions have enough energy to create nuclear reactions, producing extremely strong and extremely fast flashes of gamma rays, antimatter and other forms of radiation.

But that’s not the end of the thunderstorm gamma radiation story. Aircraft flying close to thunderstorms have also seen a faint glow of gamma radiation coming from clouds. These storms seem to have enough energy to produce a low-level simmering of gamma radiation, but something prevents it from creating an explosive burst like a popping corn kernel.

“A few aircraft campaigns tried to figure out if these phenomena were common or not, but there were mixed results, and several campaigns over the United States didn’t find any gamma radiation at all,” Cummer said. “This project was designed to address these questions once and for all.”

The research group secured the use of a NASA ER-2 High-Altitude Airborne Science Aircraft. A retrofitted U2 spy plane left over from the Cold War, it flies over twice as high as commercial aircraft and about three miles above most thunderstorms. It’s also extremely fast, giving the team the opportunity to pick the exact thunderstorms they thought were most likely to produce results.

“The ER-2 aircraft would be the ultimate observing platform for gamma-rays from thunderclouds,” said Nikolai Østgaard, professor of space physics at the University of Bergen in Norway and lead investigator of the project. “Flying at 20 km [12.4 miles], we can fly directly over the cloud top, as close as possible to the gamma-ray source.”

Because the ER-2 was the perfect solution and the team was going to fly over the right storms, the researchers figured that if these phenomena were rare, then they’d barely see any at all. But if they were common, then they’d see a lot.

And they saw a lot.

Over the course of a month, the ER-2 flew 10 flights over large storms in the tropics south of Florida, and 9 of them yielded observations of this simmer of gamma radiation, which was also more dynamic than expected.

“The dynamics of gamma-glowing thunderclouds starkly contradicts the former quasi-stationary picture of glows, and rather resembles that of a huge gamma-glowing boiling pot both in pattern and behavior,” said Martino Marisaldi, professor of physics and technology at the University of Bergen.

Given the size of a typical thunderstorm in the tropics, which get much larger than storms at other latitudes, this suggests that more than half of all thunderstorms in the tropics are radioactive. The researchers postulate that this low-level production of gamma radiation acts like steam boiling off a pot of water and limits how much energy can be built up inside.

The researchers were equally excited to see numerous examples of short duration and intense gamma radiation bursts coming from the same thunderstorms. Some of these were precisely like those that were originally detected by the NASA satellites. These almost always occurred in conjunction with an active lightning discharge. This suggests that the large electric field created by lightning is likely supercharging the already high-energy electrons, enabling them to create high-energy nuclear reactions.

But there were also at least two other types of short gamma radiation bursts that had never been seen before. One type is incredibly short, less than a thousandth of a second, while the other is a sequence of about 10 individual bursts that repeat over the course of about a tenth of a second.

“Those two new forms of gamma radiation are what I find most interesting,” Cummer said. “They don’t seem to be associated with developing lightning flashes. They emerge spontaneously somehow. There are hints in the data that they may actually be linked to the processes that initiate lightning flashes, which are still a mystery to scientists.”

If there is anybody out there worried about getting turned into the Hulk by all of this gamma radiation, Cummer added, they shouldn’t be. The amount of radiation being produced would only be dangerous if a person or object were quite close to the origination source.

“The radiation would be the least of your problems if you found yourself there. Airplanes avoid flying in active thunderstorm cores due to the extreme turbulence and winds,” Cummer said. “Even knowing what we now know, I don’t worry about flying any more than I used to.”

This research was supported by the European Research Council under the European Union's Seventh Framework Programme (FP7/2007–2013)/ERC grant agreement no. 320839 and the Research Council of Norway under contracts 223252/F50 (CoE) and contract 325582.

CITATIONS: Østgaard N., Mezentsev A., Marisaldi M., Grove J. E., Quick M., et al., Flickering Gamma-Ray Flashes, the Missing Link between Gamma Glows and TGFs. Nature Letter, DOI: 10.1038/s41586-024-07893-0 (2024)

Marisaldi, M., Østgaard, N., Lang, T., Sarria D., Mezentsev, A., et al.  Highly dynamic gamma-ray emissions are common in tropical thunderclouds, Nature Letter, DOI: 10.1038/s41586-024-07936-6 (2024)

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Study links hurricanes to higher death rates long after storms pass



U.S. tropical cyclones, including hurricanes, indirectly cause thousands of deaths for nearly 15 years after a storm. Understanding why could help minimize future deaths from hazards fueled by climate change



Stanford University





New research reveals hurricanes and tropical storms in the United States cause a surge of deaths for nearly 15 years after a storm hits.

Official government statistics record only the number of individuals killed during these storms, which are together called “tropical cyclones.” Usually, these direct deaths, which average 24 per storm in official estimates, occur through drowning or some other type of trauma. But the new analysis, published October 2 in Nature, reveals a larger, hidden death toll in hurricanes’ aftermath.

“In any given month, people are dying earlier than they would have if the storm hadn’t hit their community,” said senior study author Solomon Hsiang, a professor of environmental social sciences at the Stanford Doerr School of Sustainability“A big storm will hit, and there’s all these cascades of effects where cities are rebuilding or households are displaced or social networks are broken. These cascades have serious consequences for public health.”

Hsiang and lead study author Rachel Young estimate an average U.S. tropical cyclone indirectly causes 7,000 to 11,000 excess deaths. All told, they estimate tropical storms since 1930 have contributed to between 3.6 million and 5.2 million deaths in the U.S. – more than all deaths nationwide from motor vehicle accidents, infectious diseases, or battle deaths in wars during the same period. Official government statistics put the total death toll from these storms at about 10,000 people.

Hurricane impacts underestimated

The new estimates are based on statistical analysis of data from the 501 tropical cyclones that hit the Atlantic and Gulf coasts from 1930 to 2015, and mortality rates for various populations within each state just before and after each cyclone. The researchers expanded on ideas from a 2014 study from Hsiang showing that tropical cyclones slow economic growth for 15 years, and on a 2018 Harvard study finding that Hurricane Maria caused nearly 5,000 deaths in the three months after the storm hit Puerto Rico – nearly 70 times the official government count.

“When we started out, we thought that we might see a delayed effect of tropical cyclones on mortality maybe for six months or a year, similar to heat waves,” said Young, a postdoctoral scholar at the University of California Berkeley, where she began working on the study as a master’s student in Hsiang’s lab before he joined Stanford’s faculty in July 2024. The results show deaths due to hurricanes persist at much higher rates not only for months but years after floodwaters recede and public attention moves on.

Uneven health burdens

Young and Hsiang’s research is the first to suggest that hurricanes are an important driver for the distribution of overall mortality risk across the country. While the study finds that more than 3 in 100 deaths nationwide are related to tropical cyclones, the burden is far higher for certain groups, with Black individuals three times more likely to die after a hurricane than white individuals. This finding puts stark numbers to concerns that many Black communities have raised for years about unequal treatment and experiences they face after natural disasters.

The researchers estimate 25% of infant deaths and 15% of deaths among people aged 1 to 44 in the U.S. are related to tropical cyclones. For these groups, Young and Hsiang write, the added risk from tropical cyclones makes a big difference in overall mortality risk because the group starts from a low baseline mortality rate.

“These are infants born years after a tropical cyclone, so they couldn’t have even experienced the event themselves in utero,” Young said. “This points to a longer-term economic and maternal health story, where mothers might not have as many resources even years after a disaster than they would have in a world where they never experienced a tropical cyclone.”

Adapting in future hazard zones

The long, slow surge of cyclone-related deaths tends to be much higher in places that historically have experienced fewer hurricanes. “Because this long-run effect on mortality has never been documented before, nobody on the ground knew that they should be adapting for this and nobody in the medical community has planned a response,” Young said.

The study’s results could inform governmental and financial decisions around plans for adapting to climate change, building coastal climate resilience, and improving disaster management, as tropical cyclones are predicted to become more intense with climate change. “With climate change, we expect that tropical cyclones are going to potentially become more hazardous, more damaging, and they’re going to change who they hit,” said Young.

Toward solutions

Building on the Nature study, Hsiang’s Global Policy Laboratory at Stanford is now working to understand why tropical storms and hurricanes cause these deaths over 15 years. The research group integrates economics, data science, and social sciences to answer policy questions that are key to managing planetary resources, often related to impacts from climate change.

With mortality risk from hurricanes, the challenge is to disentangle the complex chains of events that follow a cyclone and can ultimately affect human health – and then evaluate possible interventions.

These events can be so separated from the initial hazard that even affected individuals and their families may not see the connection. For example, Hsiang and Young write, individuals might use retirement savings to repair property damage, reducing their ability to pay for future health care. Family members might move away, weakening support networks that could be critical for good health down the line. Public spending may shift to focus on immediate recovery needs, at the expense of investments that could otherwise promote long-run health.

“Some solutions might be as simple as communicating to families and governments that, a few years after you allocate money for recovery, maybe you want to think about additional savings for health care-related expenses, particularly for the elderly, communities of color, and mothers or expectant mothers,” Young said.

 

‘Cheeky’ discovery allows scientists to estimate your risk of dying using cells found in the mouth



New epigenetic clock based on easy-to-collect cheek cells accurately predicts mortality



Frontiers





We don’t all age at the same rate. But while some supercentenarians may age exceptionally slowly due to winning the genetics jackpot, a plethora of behavioral and lifestyle factors are known to speed up aging, including stress, poor sleep, poor nutrition, smoking, and alcohol. Since such environmental effects get imprinted on our genome in the form of epigenetic marks, it is possible to quantify molecular aging by characterizing the epigenome at prognostic genomic sites.

Over the past decade, scientists have developed several such ‘epigenetic clocks’, calibrated against chronological age and various lifestyle factors across large numbers of people. Most of these focused on DNA methylation in blood cells, which makes collection of samples onerous, as well as stressful for the patient. But earlier this year, scientists from the US developed a second-generation clock, called CheekAge, which is based on methylation data in easy-to-collect cells from inside the cheeks.

Now, in Frontiers in Aging, the team has shown for the first time that CheekAge can accurately predict the risk of mortality – and even if epigenetic data from another tissue is used as input.

“We also demonstrate that specific methylation sites are especially important for this correlation, revealing potential links between specific genes and processes and human mortality captured by our clock,” said Dr Maxim Shokhirev, the study’s first author and Head of Computational Biology and Data Science at the company Tally Health in New York.

CheekAge had been developed or ‘trained’ by correlating the fraction of methylation at approximately 200,000 sites with an overall score for health and lifestyle, reflecting presumed differences in physiological aging.

The biological clock is ticking

In the present study, Shokhirev and colleagues used statistical programming to see how well it predicted mortality from any cause in 1,513 women and men, born in 1921 and 1936 and followed throughout life by the Lothian Birth Cohorts (LBC) program of the University of Edinburgh. One of the LBC’s aims was to link differences in cognitive aging to lifestyle and psychosocial factors and biomedical, genetic, epigenetic, and brain imaging data. Every three years, the volunteers had their methylome in blood cells measured at approximately 450,000 DNA methylation sites. The last available methylation time point was used along with the mortality status to calculate CheekAge and its association with mortality risk. Data on mortality had been obtained from the Scottish National Health Service Central Register.

“[Our results show that] CheekAge is significantly associated with mortality in a longitudinal dataset and outcompetes first-generation clocks trained in datasets containing blood data,” concluded the authors.

Specifically, for every increase by a single standard deviation in CheekAge, the hazard ratio of all-cause mortality increased by 21%. This means that CheekAge is strongly associated with mortality risk in older adults.

“The fact that our epigenetic clock trained on cheek cells predicts mortality when measuring the methylome in blood cells suggests there are common mortality signals across tissues,” said Shokhirev.

“This implies that a simple, non-invasive cheek swab can be a valuable alternative for studying and tracking the biology of aging.”

Strongest predictors

The researchers looked at those methylation sites which were most strongly associated with mortality in greater detail. Genes located around or near these sites are potential candidates for impacting lifespan or the risk of age-related disease. For example, the gene PDZRN4, a possible tumor suppressor, and ALPK2, a gene implicated in cancer and heart health in animal models. Other genes that stood out had previously been implicated in the development of cancer, osteoporosis, inflammation, and metabolic syndrome.

“It would be intriguing to determine if genes like ALPK2 impact lifespan or health in animal models,” said Dr Adiv Johnson, the study’s last author and the Head of Scientific Affairs and Education at Tally Health.

“Future studies are also needed to identify what other associations besides all-cause mortality can be captured with CheekAge. For example, other possible associations might include the incidence of various age-related diseases or the duration of ‘healthspan’, the period of healthy life free of age-related chronic disease and disability.”

 

Radon, even at levels below EPA guideline for mitigation, is linked to childhood leukemia



Oregon State University




CORVALLIS, Ore. – A study of more than 700 counties across multiple U.S. states found a link between childhood leukemia and levels of decaying radon gas, including those lower than the federal guideline for mitigation.

The findings are important because there are few established risk factors for cancer in children and the role of the environment has not been explored much, said Oregon State University’s Matthew Bozigar, who led the research.

Radon, a naturally occurring gas, is a product of the radioactive decay of uranium, which is present in certain rocks and soils. Upon escaping from the ground, radon itself decays and emits radioactive particles that can get within the body and collect in many tissues, where they can damage or destroy the cells’ DNA, which can cause cancer.

Odorless, tasteless and colorless, radon gas dilutes quickly in open air and is generally harmless before it decays, but indoors or in areas with poor air exchange, it can easily concentrate to dangerous levels and is recognized as a significant risk factor for lung cancer.

Radon, measured with small, passive detectors and mitigated through passive or active ventilation in basements and crawl spaces, has not been linked to other cancers, according to the World Health Organization. But in an 18-year statistical modeling study of 727 counties spread among 14 states, Bozigar and collaborators not only found a connection between childhood leukemia and radon, but at concentrations below the Environmental Protection Agency’s recommended guideline for mitigation.

Becquerels per cubic meter is a unit for expressing the concentration of radioactive decay in a given volume of air. The EPA says no level of radon is safe and advises that mitigation efforts be taken when radon concentration reaches 148 becquerels per cubic meter; the study considered concentrations as low as half of that.

“This is the largest study of its kind in the U.S., but more robust research is necessary to confirm these findings on an individual level and inform decision-making about health risks from radon in this country and globally,” said Bozigar, an assistant professor in the OSU College of Health.

Leukemia, the most common cancer in children, affects the blood and bone marrow. About 3,000 new cases of childhood leukemia – defined in the study and by the National Institutes of Health as involving patients up to age 19 – are diagnosed in the United States each year, according to the NIH. The annual incidence rate is 4.8 cases per 100,000 children.

Boys are more likely to receive a leukemia diagnosis than girls, but the research suggests radon increases the likelihood of leukemia in both sexes.

“Our study design only allows us to identify statistical associations and to raise hypotheses, so studies that can better determine whether radon exposure causes childhood leukemia are needed,” Bozigar said.

Counties examined in this study were in the states of Washington, California, Idaho, Utah, New Mexico Iowa, Louisiana, Kentucky, Michigan, Georgia, New York, New Jersey, Connecticut and Massachusetts. The counties are those that during the study period reported their cancer data to the Surveillance, Epidemiology and End Results registry, a program that collects and analyzes cancer information. Known as SEER, the registry is supported by the National Cancer Institute.

Collaborating with Bozigar were scientists from the National Cancer Institute, Harvard University and Imperial College London. The research, funded in part by the Environmental Protection Agency, was published in Science of the Total Environment.

For Bozigar, the research has its roots in personal experience. He grew up in Portland, which has pockets of high radon levels, and noticed what seemed to be a high incidence of cancer, particularly in younger age groups. There were multiple cancer diagnoses among his own family and friends.

“As an epidemiologist, I started considering possible environmental causes and connected with awesome collaborators who provided important data and other resources to enable innovative new analyses,” he said. “We are working on many different radon studies, and we are continuing to find harmful effects not limited to the lungs in adults. We will have more to share in the coming months and years as our studies are published.”