Tuesday, July 27, 2021

 

Individual- and Institutional-level Concerns of Health Care Workers in Canada During the COVID-19 PandemicA Qualitative Analysis

JAMA Netw Open. 2021;4(7):e2118425. doi:10.1001/jamanetworkopen.2021.18425
Key Points

Question  What have been the range of concerns and the sources of distress among health care workers in Canada as the COVID-19 pandemic has evolved?

Findings  In this qualitative study of a public online COVID-19 forum available for 21 555 employees in a university health network, common concerns relating to the pandemic included risks of contamination, appropriate personal protective equipment, and worker safety. Although these concerns manifested as individual distress, they also intersected with and were reflective of concerns relating to health care institutions’ policies, communication practices, and politics.

Meaning  The findings suggest that a mismatch between institutional sources of concern and individual-level interventions may affect the uptake of mental health supports even as the level of distress remains high.

Abstract

Importance  Mental health and coping difficulties among health care workers (HCWs) have been reported during pandemics and particularly during the COVID-19 pandemic.

Objective  To examine sources of distress and concern for HCWs in Canada during the COVID-19 pandemic.

Design, Setting, and Participants  In this qualitative study, a critical discourse analysis was performed of questions posed by HCWs to hospital senior leadership between March 16, 2020, and December 1, 2020, through an online employee forum as part of a larger mixed-methods evaluation of a stepped-care mental health support program for HCWs at 1 of Canada’s largest health care institutions. Questions could be submitted online anonymously in advance of the virtual forums on COVID-19 by any of the University Health Network’s 21 555 employees, and staff members were able to anonymously endorse questions by upvoting, indicating that an already posed question was of interest.

Main Outcomes and Measures  Themes, text structure, and rhetorical devices used within the questions were analyzed, taking into consideration their larger institutional and societal context.

Results  Unique individual views of the forums ranged from 2062 to 7213 during the study period. Major individual-level concerns related to risks of contamination and challenges coping with increased workloads as a result of the pandemic intersected with institutional-level challenges, such as feeling or being valued within the health care setting and long-standing stratifications between types of HCWs. Concerns were frequently reported in terms of calls for clarity or demands for transparency from the institutional leadership.

Conclusions and Relevance  The findings of this qualitative study suggest that larger institutional-level and structural concerns need to be addressed if HCWs are to be engaged in support and coping programs. Potential service users may be dissuaded from seeing their needs as being met by workplace mental health interventions that solely relate to individual-level concerns.

Introduction

With ongoing social and economic restrictions, stay-at-home orders, and an increasingly burdened health care system, the COVID-19 pandemic has been an affront to the mental well-being of many individuals.1,2 Among health care workers (HCWs), adverse psychological outcomes, including anxiety, depression, insomnia, and burnout, have been widely reported.3,4 In areas with high COVID-19 exposure and case volume, HCWs are especially likely to experience distress.5 Extensive pandemic media coverage and the widespread use of social media may also contribute to perceptions of risk and difficulties coping.6 Despite this, the uptake of supports by HCWs has remained limited even when these are offered at no or low cost.7 Moreover, to our knowledge, no evidence-based interventions for HCWs during pandemic events were evaluated before the COVID-19 pandemic. A recent Cochrane review8 suggests that, in general, resilience-promoting training programs for HCWs have little or no effect on anxiety, well-being, or quality of life and provide only low-certainty evidence for subjective improvements in perceptions of resilience and depression. A consistent mismatch remains between high levels of distress among HCWs and low-quality evidence for how to manage this situation.7 During the second and third waves of the COVID-19 pandemic, contending with the range of perpetuating factors that contributed to mental distress among HCWs became a challenge. In this qualitative study, we sought to understand the range of concerns and sources of distress among HCWs at the University Health Network (UHN) in Toronto, Ontario, Canada, as the COVID-19 pandemic evolved and asked how these concerns might intersect with one another in the institutional context.

Methods
Overview

In this qualitative study, as 1 component of a mixed-methods evaluation of an internal HCW mental health support program at UHN (the UHN COVID CARES program), we conducted a critical discourse analysis (CDA) of a series of online open forums (virtual forums) hosted by senior hospital leadership. The eMethods in the Supplement gives additional details. The study was approved by the UHN Quality Improvement Review Committee and received a formal waiver from research ethics board review because this study was undertaken for the purposes of program evaluation and quality improvement. A written informed consent process was still performed for all interviews. Data were deidentified at the time of transcription (eTable in the Supplement). This study followed the Standards for Reporting Qualitative Research (SRQR) reporting guideline.9

Critical discourse analysis is a qualitative method that enables analysis of associations among language, text, talk, power, and culture; it examines vocabulary, grammar, rhetoric, and text structure within a particular social context.10 The method is used to evaluate how text and talk are produced, circulated, distributed, and consumed.11 The function of language to shape public perceptions of issues is recognized and the discourse is considered as both constitutive of and constituted by social practices.12 Although communicative expression is generated at an individual level, CDA can be used to evaluate this within a larger social, cultural, and political context.

The virtual forums that we examined have been hosted regularly during the COVID-19 pandemic as part of an ongoing communication tool between senior leadership and the 21 555 staff members who work at UHN, a large, multisite health care setting (Table 1). Any staff member can submit a question or concern related to the COVID-19 pandemic through an online platform (slido.com). Staff may submit as many questions to as many forums as they desire, although each question is not read aloud at a virtual forum. Questions submitted in advance of the live-streamed event are reviewed and prioritized by leadership and responded to on camera through a live-streamed video posted to a YouTube channel and maintained for later viewing. One feature of the forums has been upvoting: questions can be endorsed anonymously by other staff through online voting. We tracked the upvotes as an indicator of support for a given question because upvotes were used by the leadership team to prioritize questions for response and the process required engagement by staff in advance of a given forum to cast an upvote.

This CDA was embedded within the needs assessment component of the UHN COVID CARES program evaluation. In brief, UHN is a large, publicly funded hospital network that provides tertiary and quaternary care in Toronto, Ontario, Canada. The UHN COVID CARES program was developed as the first wave of the pandemic emerged in Canada (March to April 2020) and consists of (1) UHN CARES, a modified stepped-care model13 of individual mental health supports for HCWs; (2) Team CARES, proactive outreach that provides support to clinical areas affected by COVID-19; and (3) the provision of support to those working in support roles (wellness leads, social work staff, and spiritual care services). The qualitative needs assessment consisted of the CDA as well as interviews with a range of hospital staff, managers, and senior leadership team members. An ongoing mixed-methods program evaluation has also been performed. Findings have been reported through leadership channels in addition to contributing to changes within the UHN COVID CARES program.

Analysis

We examined all questions selected by leadership for the virtual forums from March 16 to December 1, 2020, and tracked the upvotes each question received. Themes were developed through an iterative close reading14 of the forum questions and their prioritization. We attended to the word choice, syntax and sentence structure, rhetorical style, and text features (such as bolded or words placed in all capital letters by the writer for emphasis). We paid particular attention to when questions were identified by the author as having been previously submitted to earlier forums. We also situated the forum questions within a broader institutional and societal context; at the start of each forum, the hospital chief executive officer provided a preamble, which we annotated. Comments relating to internal institutional events or external societal issues were cross-referenced with public sources of information, and on 2 occasions, the forums were reported by public media15,16 and included in our analysis.

At each iteration of our analysis, annotation was used to refine and link themes. In total, 4 iterations of thematic coding were performed, 2 of which entailed discussions among the authors regarding theme accuracy and completeness. The process concluded once no further modifications to the coding scheme were deemed necessary. Research memos and reflexive notes were tracked by one of us (S.G.B.). Forum questions were triangulated with the UHN COVID CARES needs assessment interviews.

Results
Forum Participants

The virtual forum comments revealed that the forums were experienced by staff as an important communication tool and were widely viewed throughout the pandemic (Figure 1). Unique views of the forums (calculated for each forum on the day the data were extracted for analysis) ranged from 2062 to 7213 individuals. This range likely underestimates the total number of individuals viewing at least some part of each forum because these forums were sometimes viewed live by multiple individuals using a single computer (eg, in a nursing station). During the study period, forum questions were submitted and upvoted anonymously; thus, data on the writer of the question were not available unless this information was included in the submission.

Intersections of Individual-Level Concerns With Structural Issues and Institutional Transparency

The tenor of early pandemic-related distress, as demonstrated through questions that used terms such as worriedfearnervous, and anxious, simultaneously revealed fears relating to risks of infection or contamination with SARS-CoV-2 and concerns about a lack of transparency within the institution. The perceived risk to HCW safety was shown by individual concerns about COVID-19 infection that intersected with a broader context of structural and institutional concerns, including supply chain limitations, rapidly changing infection control policies, and increased workflow with a smaller number of HCWs. Requests for information regarding structural and institutional issues frequently engaged language relating to clarity vs perplexity and at times implied that information might have been withheld from staff (Figure 2). As elective and nonemergency procedures were halted and clinics shut down, patients in stable condition were moved to increase bed capacity, and staff redeployment was initiated as the UHN became involved with supporting long-term care facilities in the greater Toronto area, where most COVID-related deaths occurred during the first wave of the pandemic. These scenarios were sources of uncertainty and change that challenged HCWs’ ability to cope and subsequently became central topics in the forums (Table 2). Forum contributors asked explicitly how the institution would support the mental health of HCWs, framing conventional responses such as employee assistance programs, corporate wellness initiatives, and mindfulness practices (which were demonstrated on some virtual forums) as inadequate for meeting HCWs’ needs.

Early concerns about the risks of contamination were also framed in relation to concerns about transparency. Such questions typically had an assertive, interrogative rhetorical style and were often contextualized in relation to competing interpretations of the scientific evidence regarding the pandemic. Subsequent concerns about redeployment, workloads, and patient movement were also framed by explicit demands for transparency from senior hospital leadership or had implicit suggestions that information was being withheld from HCWs in the institution (Table 2). Individual-level concerns about safety, risk, and contamination intersected with institutional-level issues about workflow, staffing levels, and a perception that the pandemic was being used to push through larger, often unpalatable institutional changes that would have otherwise been subject to greater consultation and bidirectional input.

Concerns During the Second Wave of the Pandemic

Intersecting fears about contamination and a perceived lack of transparency led to a broader set of concerns regarding the institutional context and culture, particularly regarding whether and how HCWs were valued within the institutions (Figure 3). As the pandemic evolved, sick leave policies, employee benefits, donations of food and free parking for hospital workers, and which groups of HCWs were eligible for pandemic pay (financial bonus to frontline, essential workers) from the provincial government were addressed in the virtual forums. These topics reflected a broader set of concerns regarding the institutional culture and the valuing of HCWs. Of interest, a practice of providing a “shout-out” to team members or colleagues who were believed to deserve praise had been a practice early in the forums and then ceased to occur for a period. These shout-outs were reintroduced as the second wave progressed.

The forums decreased in frequency through fall 2020 as a second-wave surge of infections affected the region. Demands for clarification or concerns about transparent communication remained consistent, continuing to overlap with themes of risk, safety, and being valued within the institution. Explicit mental health concerns were flagged less frequently during the second wave, although when they were flagged, these concerns were placed in the context of workloads, burnout, and a perception of mismatch between corporate priorities and the demands of care provision placed on frontline workers.

Social and Structural Context and Expression of Concerns

Concerns reported by staff were further shaped by events both inside and outside the health care network. Early during the forum implementation, these expressions of concern related to social media representations of the pandemic, hospital disclosures about unit outbreaks, and external reports about infection and mortality rates in long-term care. Through June and July 2020, in line with world events, transparency concerns and how HCWs were valued mapped onto larger societal issues, such as anti-Black racism and the health care system’s role in this racism.17 In the second-wave forums beginning in September 2020, an increasingly broad set of themes intersected with HCW concerns about transparency and being valued, including how the hospital system interfaced with governmental policy, particularly as the provincial government was seen to be failing to follow the suggestions of its medical advisers.18 Procedures relating to prioritization of COVID-19 vaccination eligibility at the provincial level became prominent, as did comments and criticisms regarding the enforcement of public restrictions, which arose in relation to challenges regarding workloads, fatigue, and burnout.

Discussion

In this qualitative study, similar to the published literature,19 early themes of distress in the UHN’s open forums were reported regarding personal protective equipment and worker safety. These concerns were not only associated with individual anxieties about contamination. High levels of concern involved uncertainties about viral transmission because of overstretched hospital capacities and excessive workloads, disrupted personal protective equipment supply chains, and how these disruptions would be managed in the context of a rollout of widespread social and economic restrictions.1,20 Also similar to the published literature21 was the evolution of these concerns as the pandemic evolved; sources of distress shifted to include burnout, fatigue, and moral injury associated with the conditions under which care was being provided. During each wave, forum contributors made reference to the limitations of typical or conventional approaches to HCW support, such as employee assistance programs and the promotion of mindfulness practices through wellness initiatives. The perception of these as stopgap measures and inappropriate to the nature of many HCW concerns was echoed in the qualitative interviews conducted as part of the UHN COVID CARES needs assessment and program evaluation.

In both the COVID-19 pandemic and previous pandemics, such as the severe acute respiratory syndrome pandemic, transparency and trust in the institutional setting were identified as key elements to managing fear and uncertainty.21 Trust in leadership has also been identified as a component of organizational culture that contributes to mental health outcomes among HCWs.22 Of importance, institutional sources of distress for HCWs at the UHN occurred in the context of a hospital-wide move to an incident management system. Sometimes referred to as a command and control approach, the incident management system is a top-down decision model with limited opportunities for feedback.23 At the UHN, this model was implemented within a larger context of executive leadership restructuring, which may have enhanced the scale of concerns about transparency and trust. Despite the forums being implemented to increase 2-way communication between leadership and staff, decisions about the forums (eg, changes in format) remained opaque, such that tensions surrounding transparency and trust were understood as important and central themes modeled within the forums’ processes and content.

Topics raised in the virtual forums reflected HCWs’ sense of how they were valued. The sense of being valued likewise intersected with concerns regarding transparency and trust in the institution. As indicated in the virtual forums, distress relating to these intersecting issues may have contributed to burnout and the loss of meaning within one’s work during the pandemic. This finding is similar to that reported in the literature24 on the interrelations among moral injury, self-efficacy, and loss of trust in health care institutions. This finding also reflects the ways in which distress and coping can be hindered or facilitated within a given organizational culture, particularly through leadership practices, group behaviors and relationships, and communication and participation.22 Notably, the virtual forums not only provided information about the institutional culture through the themes but also contributed to how that culture was shaped.

Strengths and Limitations

This study has strengths. The analysis provided a novel way of understanding the intersections of individual- and institutional-level challenges experienced by HCWs during the COVID-19 pandemic. This approach allowed the exploration of topics of concern not easily captured by the validated scales and quantitative measures typically used to survey HCWs’ mental health and coping. A strength of the CDA method was the capacity for making conclusions about the relationships between institutional actors and HCWs. The virtual forums were part of the way in which these relationships were structured.

This study also has limitations. Certain groups of employees may not have had access to technology in their work environment, which may have curtailed their ability to engage with the virtual forums. Although the virtual forums were available for viewing and questions could be submitted to slido.com through the external (public-facing) institutional website, this process would require time, computer literacy, and access to technology at home to be used by those without access in their work role. Moreover, many other aspects of the forums (eg, links, summaries of responses, and discussion of the forum content) were often performed by internal all-user emails. During at least some of the study period, not all employees had an institutional email address. The disparities in access to the virtual forums as a communication tool may demonstrate reliability with regard to the themes of stratifications in types of positions (us vs them) and being valued in the institution.

This analysis was also limited by a lack of knowledge about the individuals who posed questions to the forum. Therefore, how this analysis might inform supports for particular populations of HCWs should not be overstated, and generalizations should not be made about the experience of distress by any given type of HCW. The use of methods such as CDA in concert with other approaches (quantitative or qualitative) when applying a CDA to program development would be valuable.

Qualitative research is marked by its inductive analytic practices and by the way in which multiple layers of meaning and interpretation can be explored in a single data set.25 The themes described in this article are not the only possible interpretation of the CDA data. Approaching the data set with a different research question would likely yield different themes. However, this study provided an analysis of 1 layer of meaning. At this stage, the analysis only briefly considered the response of leadership to questions. An analysis of the dynamics of question and response would be a valuable subject of further study and would likely yield further findings on the role of leadership and communication in organizational culture.

Conclusions

Supports for HCWs are typically designed as individual-level interventions; however, in this study, institutional-level stressors also affected HCW distress and coping and intersected with individual-level concerns. The most notable concerns included the ways in which institutional practices conferred or denied value to HCWs and the intersection of fears about worker safety with broader concerns regarding institutional transparency. When staff are using all their waning energy to perform their duties,26 reaching out for support may seem like another untenable task, and accessing services is less likely to occur if supports appear as though they fail to align with the source of concern.7,27 Maintaining the well-being of a dedicated, effective, and energetic health care workforce may involve addressing institutional challenges in addition to individual symptoms.

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Article Information

Accepted for Publication: May 23, 2021.

Published: July 27, 2021. doi:10.1001/jamanetworkopen.2021.18425

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2021 Berkhout SG et al. JAMA Network Open.

Corresponding Author: Suze G. Berkhout, MD, PhD, University Health Network, 200 Elizabeth St, 8th Floor, Eaton North, Room 228A, Toronto, ON M5G 2C4, Canada (suze.berkhout@uhn.ca).

Author Contributions: Dr Berkhout had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: All authors.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: Berkhout, Sheehan.

Critical revision of the manuscript for important intellectual content: All authors.

Obtained funding: All authors.

Administrative, technical, or material support: All authors.

Conflict of Interest Disclosures: Dr Berkhout reported receiving grants from Mount Sinai Hospital–University Health Network Academic Medical Organization Innovation Fund during the conduct of the study. No other disclosures were reported.

Funding/Support: This work was supported by the Mount Sinai Hospital–University Health Network Academic Medical Organization Innovation Fund through the Alternative Funding Plan for Academic Health Sciences Centres of Ontario.

Role of the Funder/Sponsor: The funding source had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Additional Contributions: Alison Seto and Carol Capristan, University Health Network Centre for Mental Health, Toronto, Ontario, Canada, organized and maintained project data. They were not compensated beyond their regular salaries.

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Global dementia cases forecasted to triple by 2050

New analysis shows a decrease in prevalence due to education countered by increase due to heart health risk factors

Peer-Reviewed Publication

ALZHEIMER'S ASSOCIATION

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IMAGE: ALZHEIMER'S ASSOCIATION INTERNATIONAL CONFERENCE 2021 view more 

CREDIT: ALZHEIMER'S ASSOCIATION

DENVER, JULY 27, 2021 -- Positive trends in global education access are expected to decrease dementia prevalence worldwide by 6.2 million cases by the year 2050. Meanwhile, anticipated trends in smoking, high body mass index and high blood sugar are predicted to increase prevalence by nearly the same number: 6.8 million cases. Both according to new global prevalence data reported at the Alzheimer's Association International Conference® (AAIC®) 2021 in Denver and virtually.

With these forecasts incorporated, researchers with the Institute for Health Metrics and Evaluation at the University of Washington School of Medicine reported at AAIC 2021 that they estimate the number of people with dementia will nearly triple to more than 152 million by 2050. The highest increase in prevalence is projected to be in eastern sub-Saharan Africa, North Africa and the Middle East.

"Improvements in lifestyle in adults in developed countries and other places -- including increasing access to education and greater attention to heart health issues -- have reduced incidence in recent years, but total numbers with dementia are still going up because of the aging of the population," said Maria C. Carrillo, Ph.D., Alzheimer's Association chief science officer. "In addition, obesity, diabetes and sedentary lifestyles in younger people are rising quickly, and these are risk factors for dementia."

The U.S. National Institute on Aging estimates people over the age of 65 will make up 16% of the world's population by 2050 -- up from 8% in 2010.

Also reported at AAIC 2021 were two other prevalence/incidence studies. Key findings include:

    - Each year, an estimated 10 in every 100,000 individuals develop dementia with early onset (prior to age 65). This corresponds to 350,000 new cases of early onset dementia per year, globally.

    - From 1999 to 2019, the U.S. mortality rate from Alzheimer's in the overall population significantly increased from 16 to 30 deaths per 100,000, an 88% increase.

    - Among all areas of the U.S., mortality rates for Alzheimer's were highest in rural areas in the East South Central region of the U.S., where the death rate from Alzheimer's is 274 per 100,000 in those over 65.

Global Prevalence of Dementia Expected to Grow Rapidly through 2050

To more accurately forecast global dementia prevalence and produce country-level estimates, Emma Nichols, MPH, a researcher with the Institute for Health Metrics and Evaluation at the University of Washington School of Medicine, and colleagues leveraged data from 1999 to 2019 from the Global Burden of Disease (GBD) study, a comprehensive set of estimates of health trends worldwide. This study also aimed to improve on prior forecasts by incorporating information on trends in dementia risk factors.

Nichols and team found dementia would increase from an estimated 57.4 (50.4 to 65.1) million cases globally in 2019 to an estimated 152.8 (130.8 to 175.6) million cases in 2050. The highest increases were observed in eastern sub-Saharan Africa, North Africa and the Middle East. Their analysis suggested that projected increases in cases could largely be attributed to population growth and aging, although the relative importance of these two factors varied by world region.

What's more, Nichols and team forecasted dementia prevalence attributable to smoking, high body mass index (BMI) and high fasting plasma glucose using the expected relationship between these risk factors and dementia prevalence. They found an increase of 6.8 million dementia cases globally between 2019 and 2050 due specifically to expected changes in these risk factors. Separately and conversely, the researchers found that expected changes in education levels will lead to a decline in dementia prevalence of 6.2 million individuals globally between 2019 and 2050. Taken together, these opposing trends come close to balancing each other out.

"These estimates will allow policymakers and decision makers to better understand the expected increases in the number of individuals with dementia as well as the drivers of these increases in a given geographical setting," Nichols said. "The large anticipated increase in the number of individuals with dementia emphasizes the vital need for research focused on the discovery of disease-modifying treatments and effective low-cost interventions for the prevention or delay of dementia onset."

Recently published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association, Nichols and team used the same data set to estimate that Alzheimer's mortality rates increased by 38.0% between 1990 and 2019.

"Without effective treatments to stop, slow or prevent Alzheimer's and all dementia, this number will grow beyond 2050 and continue to impact individuals, caregivers, health systems and governments globally," Carrillo said. "In addition to therapeutics, it's critical to uncover culturally-tailored interventions that reduce dementia risk through lifestyle factors like education, diet and exercise."

The Alzheimer's Association U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER) is a two-year clinical trial to evaluate whether lifestyle interventions that simultaneously target many risk factors protect cognitive function in older adults who are at increased risk for cognitive decline.

Incidence Estimates for Younger Onset Dementia Suggest 350,000 New Cases per Year

Data on younger-onset dementia (YOD), a form of dementia where the onset of symptoms happens before age 65, is extremely limited. To better understand the incidence of YOD, Stevie Hendriks, M.Sc., student at Maastricht University in the Netherlands, and colleagues conducted a systematic literature review of all studies published during the past 30 years that reported figures on how many people developed dementia before the age of 65.

Hendriks and team found that, overall, the global incidence rate was 10 new cases each year per 100,000 persons. They also found incidence increases with age. This suggests that around 350,000 people worldwide develop younger-onset dementia every year. Incidence rates for men and women were similar, and were highest for Alzheimer's disease, followed by vascular dementia and frontotemporal dementia.

"Our findings should raise awareness in healthcare professionals, researchers and policy makers because they show that a significant number of people are newly affected by young-onset dementia every year," Hendriks said. "This shows the need for investment in tailored healthcare for this special patient group and more research into how we can best support but also prevent and treat young-onset dementia."

"People living with younger-onset Alzheimer's face unique challenges when it comes to diagnosis, family, work, finances, future care and -- with the recent FDA action -- possible treatment options. But support and information is available," said Kristen Clifford, Alzheimer's Association chief program officer. "And you have the power to make a new plan and determine how you choose to live your best life with the disease."

Rural Areas of American South Experience Disproportionate Burden of Alzheimer's Mortality

Even though average lifespan has been steadily increasing over the past several decades in the U.S., there is an increasing divergence in mortality rates among urban and rural populations. This discrepancy is likely the result of many health disparities experienced by rural residents compared to their urban counterparts, including lower socio-economic status, higher levels of chronic disease, limited availability of internet services, and less access to health services including primary care.

To specifically understand geographic variations in Alzheimer's disease mortality, Ambar Kulshreshtha, M.D., Ph.D., from Emory University, and colleagues used data from the National Center for Health Statistics to examine trends in Alzheimer's death rates between 1999 and 2019 by urbanization levels.

Kulshreshtha and team found that, from 1999 to 2019, the mortality rate from Alzheimer's in the overall population significantly increased from 16 to 30 deaths per 100,000, an 88% increase. Rural areas across the United States were shown to have higher mortality rates from Alzheimer's compared to urban areas. Those rates were highest in rural areas in the East South Central region at 274 per 100,000 in those 65 years and older, more than three times that of urban areas in the mid-Atlantic region in which mortality rates were the lowest.

"Our work shows that there is an increasing discrepancy in Alzheimer's mortality between urban and rural areas. This discrepancy could be related to, or might be the result of, other urban-rural health disparities, including access to primary care and other health services, socio-economic level, time to diagnosis, and the rising proportion of older Americans living in these areas," Kulshreshtha said. "Identifying and understanding the reasons for these health disparities is critical for allocating key social and public health resources appropriately."

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This study was partially funded by the Alzheimer's Association.

 

Stem cell treatments alleviate muscular dystrophy symptoms in compassionate-use study

Peer-Reviewed Publication

ALPHAMED PRESS

Author Photo 

IMAGE: BEATA ŚWIąTKOWSKA-FLIS, M.D., PH.D., NEUROLOGIST, UNIT HEAD AT KMC'S POLISH CENTER FOR CELL THERAPIES AND IMMUNOTHERAPY AND STUDY LEADER. view more 

CREDIT: ALPHAMED PRESS

Durham, NC - Results of a compassionate-use study released in STEM CELLS Translational Medicine show promising results for treating muscular dystrophies with mesenchymal stem cells (MSCs) derived from Wharton's jelly (WJ), a substance found in the umbilical cord. Led by doctors at Klara Medical Center (KMC), Czestochowa, Poland, these WJ-MSC treatments resulted in significant improvement in several body muscles in most of the patients, with no serious side effects.

"Administration of WJ-MSCs in neurological indications is controversial; still, this paper shows that cell therapy is a reasonable experimental treatment option, although the eligibility criteria for treatment needs to be optimized," said Beata ÅšwiÄ…tkowska-Flis, M.D., Ph.D., neurologist, unit head at KMC's Polish Center for Cell Therapies and Immunotherapy and study leader.

Muscular dystrophies encompass a group of muscle diseases caused by mutations in a person's genes that result in progressive muscle wasting and weakness. This can eventually lead to death from respiratory failure or cardiomyopathy.

"There are many kinds of muscular dystrophy, each affecting specific muscle groups, with signs and symptoms appearing at different ages, and varying in severity. Although over 30 unique genes are involved in their pathogeneses, a similar mutation in the same gene may cause a wide range of phenotypes, and distinct genes may be responsible for one identical phenotype. Because of this heterogeneity, pharmacologic treatments are limited," said Dr. ÅšwiÄ…tkowska-Flis.

The current options include supportive care and drugs. While steroids are the gold standard in pharmacotherapy, they can have significant side effects, among them weight gain, puberty delay, behavioral issues and bone fractures.

"Although stem cells cannot resolve the underlying genetic conditions, their wide-ranging therapeutic properties may ameliorate the consequences of the involved mutations. Our study describes the clinical outcomes of the compassionate use of WJ-MSCs in patients with muscular dystrophies treated in real-life settings," Dr. ÅšwiÄ…tkowska-Flis said.

The study involved 22 people with varying types of muscular dystrophies. The group was equally divided between male and female, and the median age was 33. Each person received 1-5 intravenous and/or intrathecal injections per treatment course in up to two courses every two months. Muscle strength was then assessed by using a set of CQ Dynamometer computerized force meters.

"In the group as a whole, we saw significant improvement in several body muscles, including limb, hip, elbow and shoulder," Dr. ÅšwiÄ…tkowska-Flis reported. "In the most successful case, the patient began moving without a crutch, stopped rehabilitation and rejoined a full-time job."

While these results are impressive, the doctors caution that it is too early to determine the position of MSCs in treating muscular dystrophies.

"For example, we don't know how long the therapeutic effect will last; it might be that the therapy should be repeated cyclically. Further studies are needed to optimize stem cell therapy both in terms of treatment scheme in a long period and possible synergy with pharmacological drugs and/or rehabilitation. Still, we believe the results are cautiously encouraging, especially in light of no other efficient treatment," Dr. ÅšwiÄ…tkowska-Flis said.

"While use of mesenchymal stem cells in neurological indications is controversial, this study shows that cell therapy is a reasonable experimental treatment option for this rare group of muscle diseases," said Anthony Atala, M.D., Editor-in-Chief of STEM CELLS Translational Medicine and director of the Wake Forest Institute for Regenerative Medicine. "No side effects were observed and the data stemming from this study is potentially encouraging and of interest. We look forward to the continuation of this research to further document clinical efficacy."

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The full article, "The use of umbilical cord-derived mesenchymal stem cells in patients with muscular dystrophies: results from compassionate use in real-life settings," can be accessed at https://stemcellsjournals.onlinelibrary.wiley.com/doi/abs/10.1002/sctm.21-0027.

About STEM CELLS Translational Medicine: STEM CELLS Translational Medicine (SCTM), co-published by AlphaMed Press and Wiley, is a monthly peer-reviewed publication dedicated to significantly advancing the clinical utilization of stem cell molecular and cellular biology. By bridging stem cell research and clinical trials, SCTM will help move applications of these critical investigations closer to accepted best practices. SCTM is the official journal partner of Regenerative Medicine Foundation.

About AlphaMed Press: Established in 1983, AlphaMed Press with offices in Durham, NC, San Francisco, CA, and Belfast, Northern Ireland, publishes two other internationally renowned peer-reviewed journals: STEM CELLS® (http://www.StemCells.com), celebrating its 39th year, is the world's first journal devoted to this fast paced field of research. The Oncologist® (http://www.TheOncologist.com), also a monthly peer-reviewed publication, entering its 26th year, is devoted to community and hospital-based oncologists and physicians entrusted with cancer patient care. All three journals are premier periodicals with globally recognized editorial boards dedicated to advancing knowledge and education in their focused disciplines.

About Wiley: Wiley, a global company, helps people and organizations develop the skills and knowledge they need to succeed. Our online scientific, technical, medical and scholarly journals, combined with our digital learning, assessment and certification solutions, help universities, learned societies, businesses, governments and individuals increase the academic and professional impact of their work. For more than 200 years, we have delivered consistent performance to our stakeholders. The company's website can be accessed at http://www.wiley.com.

About Regenerative Medicine Foundation (RMF): The non-profit Regenerative Medicine Foundation fosters strategic collaborations to accelerate the development of regenerative medicine to improve health and deliver cures. RMF pursues its mission by producing its flagship World Stem Cell Summit, honouring leaders through the Stem Cell and Regenerative Medicine Action Awards, and promoting educational initiatives.

 THE LANGUAGE OF THE ORISHA

'Talking drum' shown to accurately mimic speech patterns of west African language

Analysis demonstrates the value of studying non-western cultures to bring important new insights to mainstream musicology and linguistics

Peer-Reviewed Publication

FRONTIERS

Dundun drummers 

IMAGE: THE IFESOWAPO DÙNDÚN ENSEMBLE PERFORMING IN IGBO ORA, SOUTHWEST NIGERIA. view more 

CREDIT: DR CECILIA DUROJAYE

Musicians such as Jimi Hendrix and Eric Clapton are considered virtuosos, guitarists who could make their instruments sing. Drummers in west Africa who play hourglass-shaped percussion instruments called dùndúns can make their instrument not only sing, but talk. New research published in the journal Frontiers in Communication is one of the first to show the high degree of acoustic correlation between these talking drums and the spoken Yorùbá language.

Dùndún drumming is a musical-oral tradition where skilled drummers, manipulating the intensity and pitch of the instrument, can mimic Yorùbá, a tonal language mainly spoken in southwest Nigeria. Dubbed 'talking drums', dùndúns can be used as purely musical instruments or what scientists refer to as speech surrogates, imitating the three tones of the language.

The authors of the new paper describe how they analyzed and compared 30 spoken and sung verbal snippets with corresponding drum and song excerpts. They found that the dùndún very accurately mimics the microstructural characteristics of Yorùbá vocalization directly, while the fidelity decreases when the drums are used purely for music or less direct communication such as song. The scientists also distinguish four modes through which the talking drum connects music and language - rhythm, singing, drum talking-performative and drum talking-direct.

New understandings between music and speech

Equally important, the acoustical analysis demonstrates how studying non-western cultures can enrich the way scientists more generally understand the relationship between music and speech, as well as how humans process them, according to lead author Dr Cecilia Durojaye, a researcher and musicologist affiliated with the Department of Psychology at Arizona State University.

"These kinds of multicultural findings are useful for considering deeper relationships and understanding of types of auditory communication and the evolution of language and music," she said. "The talking drum is unique in that it has a foot in both language and music camps, and because its existence reminds us of the thin boundary between speech and music."

While the talking drum is specific to the Yorùbá language, speech surrogacy in music occurs across cultures, so the research can contribute to how scientists understand the phenomenon in general and in the Yorùbá culture specifically, Durojaye explained.

The study involved comparing the timing patterns between recorded drum excerpts and clips of speech and song from Yorùbá vocal performers and professional drummers. The researchers also extracted details on frequency and intensity of the recordings to understand the structural commonalities in these different forms of communication.

Purposes of speech surrogacy

"Our finding that verifies distinct drumming modes varying between musical functions and speech surrogacy helps clarify how the talking drum is used in specific functional ways relating to different types of communication," Durojaye said.

Speech surrogacy serves a number of functions, from disseminating oral history to reciting poetry and proverbs. "Through musical instruments like these drums, one can know the history of a particular culture or a form of knowledge dissemination, as well as aspects of how the people think, their belief systems and values, and what is likely important to them," she noted.

There is still much that scientists don't understand about how these speech surrogate systems operate in terms of the formal linguistic properties they contain, Durojaye said. For instance, how does each mode capture and encode tone and syllables? Or how is the information transmitted on a syntactic or semantic level? And what is the extent of their overlap with musical properties?

"Our study, which focuses on the acoustic properties of spoken, sung and drummed forms, represents one of the first steps towards understanding these various structures," Durojaye said. "We continue to explore this unique instrument, which has the potential for enhancing our understanding of music and language processing, especially from a non-western perspective."

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New study: Lower-wealth volunteers experience greater health gains from volunteering than wealthier volunteers

Volunteering's health effect among older adults in the lowest wealth quintile -- whose average wealth is negative--is stronger than for the highest wealth quintile of older adults, report investigators in the American Journal of Preventive Medicine

Peer-Reviewed Publication

ELSEVIER

Ann Arbor, July 27, 2021 - Formal volunteering in later life is beneficial for both physical and psychological well-being. However, research has shown that older adults with key advantages, such as wealth, are more likely to volunteer and reap its benefits. In a new study appearing in the American Journal of Preventive Medicine, published by Elsevier, investigators found that lower-wealth volunteers may experience even greater health gains than higher-wealth volunteers.

In the United States, around 29 million older adults volunteer through organizations each year, contributing three billion hours of service to the community at large. Volunteering is regarded as beneficial for volunteer health, and some studies have even suggested the possibility that volunteering could become a low-cost, sustainable public health intervention.

"Earlier studies with two to 20 years of follow-up have reported that regardless of how volunteering was measured (for example, status, intensity, duration, or consistency), the activity was associated with higher self-rated health and fewer depressive symptoms," explained co-investigator Seoyoun Kim, PhD, Department of Sociology, Texas State University, San Marcos, TX, USA. "However, research points to potential selection bias, because older adults with key advantages, such as wealth, are more likely to volunteer and reap its benefits."

"In this new study, we wanted to challenge the 'single regression coefficient' for the benefits of volunteering on health in the entire population," noted co-investigator Cal Halvorsen, PhD, MSW, Department of Social Work, Boston College, Boston, MA, USA. "We were interested in whether the effects of formal volunteering on health were different between the wealthiest and the least wealthy individuals (highest 20 percent versus lowest 20 percent). We were also interested in understanding the practical implications, particularly for low-wealth individuals."

The investigators analyzed data from nearly 90,000 observations from the Health and Retirement Study, a longitudinal and nationally representative US study funded by the National Institute on Aging and the Social Security Administration that surveys approximately 20,000 older adults every two years. They included observations from 2004 to 2016 using data from a previous wave to predict outcomes in the next wave to alleviate concerns about reverse causality. They also created a quasi-experimental study using statistical analyses to adjust for the fact that wealthier older adults were more likely to volunteer, among other factors, thereby reducing bias in their results.

Findings showed that in the full sample, volunteering enhanced self-reported health and reduced depressive symptoms for older adults in general. Significantly, those in the lowest wealth quintile experienced more gains in self-reported health from volunteering compared to their wealthy counterparts. Volunteering was associated with fewer depressive symptoms regardless of wealth status.

"This study enhances our understanding of how formal volunteering influences health and well-being in two key ways," commented Dr. Kim. "First, we echo previous research that finds that volunteering is beneficial for older adults' physical and mental health. And second, through our advanced statistical procedures, we show that lower-wealth volunteers may experience even greater gains in self-reported health than higher-wealth volunteers."

"It is noteworthy that formal volunteering may operate as a health equalizer," added Dr. Halvorsen. "Policymakers and charitable organizations tend to focus on the middle class to wealthy volunteers, but it's important to eliminate barriers to volunteering among the least wealthy, such as lack of transportation, discrimination, or lack of organizational support."

"We already know that volunteering, in general, is good for you. Yet what is notable about this study is that it shows how volunteering's health effect among older adults in the lowest wealth quintile--whose average wealth is negative--is stronger than for the highest wealth quintile of older adults. This is important, as the lowest wealth quintile of older adults began with lower self-rated health," stated the investigators.

Volunteering can provide many benefits to individuals, and it is possible that being involved in the work of nonprofit and community organizations increases one's social networks and access to important health promotion programs which, in turn, influence the health of the lowest wealth volunteers the most.

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Team studies “vampires of the Great Lakes”

Meeting Announcement

UNIVERSITY OF ILLINOIS GRAINGER COLLEGE OF ENGINEERING

Lamprey 

IMAGE: LAMPREYS AT THE GREAT LAKES FISHERY COMMISSION OFFICE IN ANN ARBOR, MI view more 

CREDIT: GREAT LAKES FISHERY COMMISSION

Have you ever thought about trying to build a better mousetrap?  An Illinois team is trying to do just that, but targeting fish, not mice.  Thanks to a $20,000 grant from the Great Lakes Fishery Commission, researchers are studying the effects of turbulence on invasive sea lamprey to learn more about what efforts might best deter them and what might make them ‘choose’ to swim into a particular area.

Called the “vampires of the Great Lakes,” sea lamprey are parasitic fish that kill and injure local species and inflict severe damage on the fisheries economy. The pilot project is taking place this summer at the Hammond Bay Biological Station in Millersburg, Mich. It is a collaboration between CEE assistant professor Rafael Tinoco and Cory Suski, a professor in UIUC’s Department of Natural Resources and Environmental Sciences.

“Through a series of laboratory experiments with live, upstream-migrating lamprey, we will evaluate the response of lamprey to specific features of turbulent flow, changing the intensity, orientation, periodicity, and size of coherent flow structures generated by different configurations of in-stream structures,” Tinoco said. “Identifying the lamprey preference for specific hydrodynamic features will help us redesign more effective traps and barriers, by either enhancing their preferred flow features or amplifying the ones they avoid.”

The Great Lakes Fishery Commission (GLFC) is an international treaty organization established in 1955 between Canada and the United States that works to control sea lamprey population through the development and use of lampricides, barriers and traps.