Friday, January 28, 2022

Creating non-hallucinogenic analogs of LSD and psilocybin to treat mental illnesses

by Bob Yirka , Medical Xpress

A combined team of researchers from the Shanghai Institute of Biochemistry and Cell Biology and ShanghaiTech University's, iHuman Institute has created non-hallucinogenic analogs of LSD and psilocybin for possible treatment of mental illnesses. In their paper published in the journal Science, the group describe the analogs they created and how they performed in mice.

In recent years, scientists have found that some hallucinogens, such as LSD and psilocybin, can provide relief for patients suffering from chronic depression and other mental illnesses like PTSD. And while many patients may enjoy the hallucinogenic experience, many do not. Scientists have therefore been taking a closer look at hallucinogens to find the mechanisms that provide relief to those suffering from depression—and if possible, to determine if the hallucinogenic effects of such drugs are necessary for treatment.

In this new effort, the researchers took a close look at both LSD and psilocybin using X-ray crystallography, and were able to determine their conformations when they become bound to the neural receptor 5-HT2AR. They found that both molecules could bind to 5-HT2AR in two ways, resulting in unique conformations. They then created compounds that would bind to 5-HT2AR in the secondary type of binding they discovered.

The researchers administered the compounds to mice that were stressed to the point of depression by being hung from their tails or forced to swim for extended periods. To test whether the mice were experiencing hallucinogenic effects, they used the twitch test. Prior research has shown that when mice are given hallucinogens, their heads twitch in a unique way. And to test whether symptoms of depression eased, they observed whether the test mice engaged in activities they had stopped doing when depression set in. The researchers found no head twitching and a renewed interest in normal activities. They suggest their work represents a good starting point for the development of non-hallucinogenic analogs of common hallucinogenic drugs.Active ingredient in magic mushrooms reduces anxiety and depression in cancer patients

More information: Dongmei Cao et al, Structure-based discovery of nonhallucinogenic psychedelic analogs, Science (2022). DOI: 10.1126/science.abl8615

Journal information: Science

Scientists develop novel non-hallucinogenic rapid-acting antidepressant compounds

Peer-Reviewed Publication

CHINESE ACADEMY OF SCIENCES HEADQUARTERS

According to the World Health Organization, approximately 280 million people worldwide live with depression. About two-thirds of those with depression have suicidal ideation, and 25% attempt suicide. Suicide is also one of the leading causes of death in 15-29-year-olds, with nearly 50% of suicides occurring in people with depression. However, conventional antidepressants produce effects only after weeks of daily dosing and do not alleviate all disease symptoms. Furthermore, 30% of patients with depression don’t respond to current antidepressant therapy.

In a study published in the journal Science, the labs led by Dr. WANG Sheng at the Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences, and Dr. CHENG Jianjun at the iHuman Institute, ShanghaiTech University reported for the first time a structure-based strategy to design novel rapid-acting antidepressant compounds, a discovery that could accelerate the discovery of non-hallucinogenic psychedelic analogs.

Over the past ten years, many researchers and clinicians have come to believe that psychedelic pharmacology may represent a new era in psychiatric therapeutics. Most clinical studies described during this time have focused on psilocybin, a compound found in the Psilocybe genus of mushrooms, some of which were used for healing and spiritual purposes by the Mayan and Aztec cultures of Mesoamerica.

The US Food and Drug Administration granted psilocybin “breakthrough therapy” status for the treatment of major depressive disorder and drug-resistant depression in 2019. The results of a phase II clinical trial showed that psilocybin can greatly improve the symptoms of patients with depression within one day after dosing, and the effect can last for more than three months. However, the hallucinogenic effects of these drugs remain a concern, and scientists have been unsure whether hallucinations are therapeutically important or just a side effect.

Psilocybin is converted in the liver to pharmacologically active psilocin, which then acts on serotonin 2A receptors (5-HT2AR) in the brain. In this study, scientists produced six new crystal structures of 5-HT2AR that bound to compounds including psilocin, lysergic acid diethylamide (i.e., LSD, one of the most potent psychedelics), serotonin, and non-hallucinogenic psychedelic analogues. They found that psilocin displayed an unexpected binding mode known as the extended binding pocket (EBP) mode, which is regulated by lipids. They also found that compounds that occupied more EBP than orthosteric binding pocket (i.e., OBP, the usual site for receptor binding) were associated with anti-depressive activity in test animals without triggering hallucinations. Thus, scientists designed several new psychedelic analogues they thought would favor EBP binding over OBP binding.

Scientists then repeated the behavioral tests on mice receiving these compounds and found that two compounds, dubbed IHCH-7079 and IHCH-7806, did not trigger head twitch behavior, which has long been seen as indicative of hallucinations. However, the mice displayed standard behavioral measures suggesting the compounds were effective antidepressants.

These findings provide a solid foundation for the structure-based design of safe and effective non-hallucinogenic, rapid-acting antidepressants. It should be pointed out that the compounds reported in this work are not approved drugs, and further preclinical and clinical studies are needed to verify their safety and antidepressant effects in humans.

JOURNAL

Science

DOI

10.1126/science.abl8615

ARTICLE TITLE

Structure-based discovery of nonhallucinogenic psychedelic analogs

ARTICLE PUBLICATION DATE

27-Jan-2022

An electrically charged thin film patch used to promote wound healing

by Bob Yirka , Medical Xpress

A team of researchers working at the University of Electronic Science and Technology of China has developed an electrically charged thin film patch for promoting faster wound healing. In their paper published in the journal Science Advances, the group describes their patch, how it works, and how well it performed when tested on rats.

Humans have been looking for ways to promote faster healing of wounds for thousands of years in order to reduce both the length of time a patient experiences pain and the chances of infection. In this new effort, the researchers created an electrically charged thin film patch that helps wounds heal faster.

Prior research has shown that applying electricity to wounds induces faster healing. Unfortunately, this approach has been limited by bulky and complicated machinery. In this new effort, the researchers created a small, flexible patch that takes advantage of electricity's healing powers without the need for such equipment.

The patch is four-layered: the top and bottom layers are made of a type of electrically charged plastic and they get their charge through contact with the skin. One of the middle layers is made of a silicone rubber gel that helps the patch conform to the contours of the skin. The other middle layer is made of a shape-memory alloy material; its purpose is to pull the sides of the wound closer. The resulting thin-film patch is just 0.2 millimeters thick.

The researchers applied the patch to two kinds of wounds on test rats—straight and circular. They compared healing rates against other types of dressings and against undressed wounds. They found that circular wounds treated with the patch were 96.8% healed after eight days, compared to 76.4 to 79.9% for other dressings. Those that went untreated were only 45.9% healed. They found similar results in straight-line wound healing, though all of them healed faster than the circular wounds—such wounds require far less new skin development to heal.

The researchers suggest their patch is a viable wound treatment option and plan to continue upgrading its features, such as allowing for differently shaped wounds.

Printing technique creates effective skin equivalent, heals wounds

More information: Guang Yao et al, A programmable and skin temperature–activated electromechanical synergistic dressing for effective wound healing, Science Advances (2022). DOI: 10.1126/sciadv.abl8379

Journal information: Science Advances

Hard barriers and soft power: Study assesses outsider perceptions of border walls

by Alina Ladyzhensky, University of Pennsylvania

When it comes to being divisive, it doesn't get more literal than a wall. Walls exist as a means of separation, creating a sense of security by keeping something—or more typically someone—out. And whether it's separating Americans and Mexicans, Israelis and Palestinians, East Germans and West Germans, or any other two groups, the political divisiveness of border walls makes headlines around the globe.

Noting the strong reactions that many people have toward border walls, Penn researchers Diana Mutz and Beth Simmons wondered if walls carried a more universal meaning in the human mind, regardless of a person's nationality. And as it turns out, they do—with real implications for international influence and soft power.

Mutz, the Samuel A. Stouffer Professor of Political Science and Communication and director of the Institute for the Study of Citizens and Politics at the Annenberg School for Communication and in the Department of Political Science in the School of Arts & Sciences, was interested in the political psychology of distance and separation. Simmons, the Andrea Mitchell University Penn Integrates Knowledge Professor in Law, Political Science, and Business Ethics at Penn Carey Law, had an ongoing project involving the consequences of increased national border infrastructure around the world.

These related research interests converged as Mutz and Simmons developed an experiment to assess how border walls influence the way that individuals regard a foreign country—and crucially, in a way that steers clear of highly polarized political feelings about border policies where they live.

"It struck us both as intuitive and consistent with a lot of psychological research that walls connote unfriendliness, a desire to be separate from what is on the other side," Mutz says. "We thought the best way to untangle politics from perceptions would be to design an experiment that forces respondents to think beyond their own political context."

Their findings, "The psychology of separation: border walls, soft power, and international neighborliness," were recently published in the Proceedings of the National Academy of Sciences. The study revealed that the presence of walls lowered participants' evaluations of the bordering countries, and implied hostile international relationships.

The consistent negative impressions that participants had of countries with border infrastructure, the co-authors say, are important for policymakers to bear in mind. These findings speak directly to the potential impact of border security policies on a country's "soft power," the kind of influence, both on leaders and the public, that a country gains when seen favorably by those in other countries. Soft power is determined by foreign perceptions of the attractiveness of a society's culture, foreign policies, and values.

Working with a team of graduate students, the co-authors assembled found footage from the internet on Tajikistan and Kyrgyzstan, two countries that they felt respondents were likely to know very little about. Mutz and Simmons wanted participants to be unfamiliar with the locations involved, so their judgments wouldn't be swayed by prior knowledge of that country's reputation.

With the help of Waldo Aguirre and Anna Gamarnik from Annenberg's IT department, they created a short documentary about Tajikistan's culture and history. Respondents were shown one of three versions of the film, then asked to rate their impressions of the countries depicted. In one version, the narrator mentions that Tajikistan shares a border with Kyrgyzstan, shown as a valley between two mountains. In another version, the video refers to a "border wall," with an image of a wall presented. The third version also shows a wall, and explicitly mentions that neighboring Kyrgyzstan originally built it.

They conducted the experiment in three countries with varied recent experiences of border infrastructure: the United States, where border walls are extensive but partial and politically controversial; Ireland, where border barriers have been dismantled since the late 1990s; and Turkey, whose border abuts a civil war in Syria and who has almost fully sealed off its southern and eastern borders.

In addition to participants having negative perceptions of countries with border walls, the results showed that the government of the country responsible for erecting the wall was regarded especially unfavorably. And while walls increased perceptions of a country's border security, it lowered respondents' perceived security of the people who live there.

As the authors note, these reactions were consistent regardless of participants' political views, the political contexts of their home countries, and their distance from an international border.

"People in Ireland, the U.S., and Turkey all responded in the same way to the presence of a wall, and they all held the country that built it in lower esteem," Simmons says. "We had assumed that those who favored walls in their own domestic political context would be less likely to draw these same inferences. That's not at all what we found."

Positive feelings about a country's "soft" attributes can enhance a country's military influence and other sources of power. The potential damage that border walls may have on a nation's image can, subsequently, erode its soft power.

This doesn't mean that states should never erect border walls, the researchers say. "But it is important to appreciate the possibility that some symbolic security measures—of which walling may be one—may reduce a state's attractiveness more than they enhance national security."

Border walls could have unintended consequences on trade, study finds

More information: Diana C. Mutz et al, The psychology of separation: Border walls, soft power, and international neighborliness, Proceedings of the National Academy of Sciences (2022). DOI: 10.1073/pnas.2117797119

Journal information: Proceedings of the National Academy of Sciences

Provided by University of Pennsylvania

Geoscience researchers call for updated metaphor to help make field more inclusive and equitable

by Rylie Koester, University of Kansas

As a Black woman in geosciences, especially a full professor who holds an endowed chair position, Asmeret Asefaw Berhe has jokingly called herself a unicorn.

"That's how rare it is," said Berhe, professor of soil biogeochemistry and Ted and Jan Falasco chair in earth science and geology in the Department of Life and Environmental Sciences at the University of California Merced. "There is no reason why in 2022 that should be the case."

The geosciences are among the least diverse STEM fields, with about 90% of doctorates going to white people and less than 4% of tenured faculty positions in geoscience departments being held by people of color.

To help combat this problem, a group of geoscience researchers is reimagining the "leaky pipeline" metaphor traditionally used to describe the lack of diversity and inclusion in the academy. The authors, including Berhe and University of Kansas researcher Blair Schneider, have written a paper in Nature Geoscience describing the "hostile obstacle course" that Black, Indigenous and other people of color face as they attempt to advance their careers.

"The leaky pipeline implies that the attrition of white women, BIPOC and members of other minoritized communities is a passive process: nothing more than a 'drip, drip' from holes within an otherwise robust system," the authors wrote. "In reality, we (and others) argue that the imagery of a leaky pipeline fails to represent the exclusionary experiences of many."

The paper, officially published Jan. 21, has already received 14,000 online views and more than 1,600 tweets. It currently ranks in the top 1% of most-viewed articles tracked by Altmetric.

The hostile obstacle course metaphor puts emphasis on systemic problems instead of individuals and better represents the experiences of marginalized geoscience scholars, the authors said. The obstacle course recognizes that barriers are not experienced equally.

"Our hope is that this reframing of the conversation puts the responsibility to address it rightfully with the leaders in our academic institutions, scientific leaders and senior folks who should take the responsibility to fix the current climate," Berhe said, "so that when we actually recruit students from whatever background it might be, they actually find a safe place—a home—in our academic institutions in science, and they don't experience isolation, microaggression, harassment and discrimination."

The authors presented an image to describe the metaphor and accompany the paper. It shows a white man and a Black woman preparing to ascend a staircase. The stairs represent career progression and retention in the field, with the top being career achievement. Each person faces obstacles on their climb, but the woman of color has far more and different kinds of barriers—racism, sexism, sexual harassment, gender harassment and more—to overcome.

Schneider, associate researcher and science outreach manager at KU's Kansas Geological Survey, is one of the paper's seven authors. Like Berhe, she is a co-principal investigator for the ADVANCEGeo Partnership, the group that wrote the paper and an effort funded by the National Science Foundation to address sexual harassment and other exclusionary behaviors that lead to hostile workplaces in the earth, space and environmental sciences.

"I really do appreciate the people who originally brought forth the leaky pipeline metaphor," Schneider said. "They were starting a dialog that hadn't happened yet. But let's update this to actually include this intersectionality component and the different barriers people face based on their identities."

Growing up, Schneider said she never knew pursuing a career as a scientist was an option for someone like her.

"None of that was promoted to me," she said. "I do feel like it was kind of luck along the way that I ended up where I am."

As a white woman, Schneider said that even though she has faced sexism and harassment in her field, her experiences can't compare to her colleagues of color.

"I haven't dealt with any racism," Schneider said. "I haven't feared for my life in certain situations like other colleagues and friends have, and so it's also very eye-opening. I don't think I would still be here if I had gone through that."

Moving forward, the group hopes this metaphor will reframe conversations and inspire new policies to recruit and retain people with diverse identities and lived experiences.

"Policies that you put in place for white women aren't necessarily going to help women of color," Schneider said. "Policies that you put in place to help women in general don't necessarily help those who have disabilities."

"It's important to me to make sure that the next generation of scholars who are coming behind me don't have to go through the same stuff," Berhe added. "There are plenty of people who are still starting to climb on that staircase, and I really want us to remove those obstacles because we have an obligation to provide everyone with a safe learning and work environment."How scientific leaders can enact anti-racist action in their labs

More information: Asmeret Asefaw Berhe et al, Scientists from historically excluded groups face a hostile obstacle course, Nature Geoscience (2021). DOI: 10.1038/s41561-021-00868-0

Journal information: Nature Geoscience

Provided by University of Kansas

Where mathematics and a social perspective meet data

by Kim McGrath, Wake Forest University

Community structure, including relationships between and within groups, is foundational to our understanding of the world around us. New research by mathematics and statistics professor Kenneth Berenhaut, along with former postdoctoral fellow Katherine Moore and graduate student Ryan Melvin, sheds new light on some fundamental statistical questions.

"When we encounter complex data in areas such as public health, economics or elsewhere, it can be valuable to address questions regarding the presence of discernable groups, and the inherent "cohesion" or glue that holds these groups together. In considering such concepts, socially, the terms "communities," "networks" and "relationships" may come to mind," said Berenhaut.

The research leverages abstracted social ideas of conflict, alignment, prominence and support, to tap into the mathematical interplay between distance and cohesiveness—the sort evident when, say, comparing urban and rural settings. This enables adaptations to varied local perspectives.

"For example, we considered psychological survey-based data reflecting differences and similarities in cultural values between regions around the world—in the U.S., China, India and the EU," Berenhaut said. "We observed distinct cultural groups, with rich internal network structure, despite the analytical challenges caused by the fact that some cohesive groups (such as India and the EU) are far more culturally diverse than others. Mark Twain once referred to India as 'the country of a hundred nations and a hundred tongues, of a thousand religions and two million gods." Regions (such as the Southeast and California in the U.S.) can be perceived as locally distinct, despite their relative similarity in a global context. It is these sorts of characteristics that we are attempting to detect and understand."

The paper, "A social perspective on perceived distances reveals deep community structure," is published in the Proceedings of the National Academy of Sciences.

"I am excited by the manner in which a social perspective, along with a probabilistic approach, can illuminate aspects of communities inherent in data from a variety of fields," said Berenhaut. "The concept of data communities proposed in the paper is derived from and aligns with a shared human social perspective. The work crosses areas with connections to ideas in sociology, psychology, mathematics, physics, statistics and elsewhere."

Leveraging our experiences and perspectives can lead to valuable mathematical and statistical insights.Childhood exposure to diversity is best chance for community cohesion in immigration

More information: Kenneth S. Berenhaut et al, A social perspective on perceived distances reveals deep community structure, Proceedings of the National Academy of Sciences (2022). DOI: 10.1073/pnas.2003634119

Journal information: Proceedings of the National Academy of Sciences

Provided by Wake Forest University

What wintering squirrels can teach astronauts

by University of Montreal

Microbes help hibernating animals recycle nutrients, maintain muscle through winter — Thirteen-lined ground squirrels curled up for seasonal hibernation can slow their metabolic

When bears and ground squirrels hibernate in winter, they stop eating, lasting until spring simply on the fat reserves they've stored up in their bodies. Usually, this sort of prolonged fasting and inactivity would significantly reduce the mass and function of muscle, but hibernators don't suffer this fate. How they avoid it, however, has been a mystery.

Now, in research published in Science, an Université de Montréal biologist has figured out why, and his findings could have implications for, of all things, the future of space travel . By studying a variety called the 13-lined ground squirrel that is common in North America, Matthew Regan has confirmed a theory known as "urea nitrogen salvage" dating back to the 1980s.

The theory posits that hibernators harness a metabolic trick of their gut microbes to recycle the nitrogen present in urea, a waste compound that is usually excreted as urine, and use it to build new tissue proteins.

How could this discovery be of use in space? Theoretically, Regan posits, by helping astronauts minimize their own muscle-loss problems caused by microgravity-induced suppression of protein synthesis and which they now try to reduce by intensively exercising.

If a way could be found to augment the astronauts' muscle protein synthesis processes using urea nitrogen salvage, they could be able to achieve better muscle health during long voyages into deep space in spacecraft too small for the usual exercise equipment, the argument goes.

"Because we know which muscle proteins are suppressed during spaceflight, we can compare these proteins with those that are enhanced by urea nitrogen salvage during hibernation," said Regan, who carried out this research while a postdoc at the University of Wisconsin-Madison.

He is now continuing his work through a Canadian Space Agency research grant at UdeM, where he last year took up a position as assistant professor of animal physiology in the Department of Biological Sciences.

"If," Regan continued, "there is an overlap between the proteins in spaceflight and the ones from hibernation, then it suggests this process may have benefits to muscle health during spaceflight."

A model hibernator

In his study, Regan designed a series of techniques and experiments to investigate the major steps in the urea salvage process and provide evidence for whether or not they occur in the 13-lined ground squirrel when it hibernates.

To do that, in their lab they injected their test squirrels' blood with "double-labeled" urea, meaning the urea's carbon atom was 13C instead of the usual 12C, and its nitrogen atoms were 15N instead of the usual 14N. These labels allowed them to track the urea-sourced carbon and nitrogen through the different steps of the urea nitrogen salvage process.

That process, they found, led from the initial transport of urea from the blood into the gut, to the breakdown of urea into its component parts by gut microbes, to the flow of substances—called metabolites—containing urea nitrogen back into the animal, and finally to the eventual appearance of this urea nitrogen in tissue protein.

"Essentially, seeing 13C and/or 15N in metabolites at these various steps indicated that they originated from urea, and thus, that the hibernator was using urea nitrogen salvage," said Regan.

He did his experiments on squirrels with and without gut microbiomes at three times of the year: summer, when they were active and not hibernating; early winter, when they were one month into fasting and hibernation; and late winter, when they were four months into fasting and hibernation.

'Clear evidence of nitrogen salvage'

What they found was definitive: at each step of the process, there was clear evidence of urea nitrogen salvage by the squirrels with intact gut microbiomes.

Importantly, the squirrels with depleted gut microbiomes displayed no evidence of urea nitrogen salvage at any step, confirming this process was wholly dependent on the gut microbes' ability to degrade urea, something the squirrels themselves cannot do.

Regan and his team also made two other important findings:

First, the incorporation of urea nitrogen into the tissue protein of the squirrels was highest during late winter, suggesting that urea nitrogen salvage becomes more active as the hibernation season proceeds. This is unlike most physiological processes during hibernation, when tend to be significantly reduced.
Second, there was evidence the microbes themselves were using the urea nitrogen to build their own new proteins, which is useful for them because they, like the squirrel, are under conditions of fasting hibernation. Thus, both the squirrel and its microbes benefit from urea nitrogen salvage, which makes this process a true symbiosis.

What this means, Regan said, is that the squirrels emerge from hibernation in the spring in good shape. This is important because the year's only mating season, which is a time of intense physical activity for both males and females, occurs directly after they emerge from hibernation. Tissue function—particularly muscle tissue function—is therefore highly important for a successful mating season.

"By facilitating muscle protein synthesis late in the hibernation season, urea nitrogen salvage may help optimize the emerging squirrels' muscle function and contribute to their reproductive success during the mating season," said Regan. "Urea nitrogen salvage may therefore enhance the animals' overall biological fitness."

Starving masses and the elderly

Beyond the implications for space travel and the health of astronauts, Regan's discovery could have more immediate impacts now right here on Earth—in the starving masses of the underdeveloped world, and in the elderly.

Hundreds of millions of people globally experience muscle wasting as a consequence of various conditions—undernourishment, for instance, affects over 805 million people globally. More prevalent in Canada is sarcopenia, an age-related decline in muscle mass stemming from anabolic insensitivity that affects all humans, leading to a 30- to 50-per-cent decline in skeletal muscle mass between the ages 40 and 80.

"The mechanisms that mammals like the 13-lined ground squirrel have naturally evolved to maintain protein balance in their own nitrogen-limited situations may inform strategies for maximizing the health of other nitrogen-limited animals, including humans," said Regan. One solution might be to develop a pre- or probiotic pill that people could take to promote a gut microbiome of the kind that hibernators like squirrels have.

"To be clear, these applications, though theoretically possible, are a long way from delivery, and a lot of additional work is needed to translate this naturally evolved mechanism safely and effectively to humans," Regan said.

"But one thing I find encouraging is that a study from the early 1990s provided some evidence that humans are capable of recycling small amounts of urea nitrogen via this same process. This suggests that the necessary machinery is in place. It just needs to be optimized."Arctic ground squirrels recycle nutrients to endure deep hibernation

More information: Matthew D. Regan et al, Urea nitrogen recycling via gut symbionts increases in hibernating ground squirrels over the winter, Science (2022). DOI: 10.1126/science.abh2950. www.science.org/doi/10.1126/science.abh2950

Journal information: Science

Provided by University of Montreal

Morocco starts construction of anti-Covid vaccine plant

Morocco's King Mohammed VI (C) chairs a ceremony to launch

the construction of a Covid-19 vaccine manufacturing plant in the region of Benslimane

Thu, January 27, 2022

Morocco on Thursday inaugurated construction of an anti-Covid vaccine manufacturing plant in partnership with Swedish firm Recipharm, the official news agency MAP reported.

The factory to be known as Sensyo Pharmatech will produce vaccines against coronavirus and other diseases, with production expected to reach 116 million units in 2024, MAP said.

It was launched in Benslimane, a region of Morocco's economic hub Casablanca during a ceremony attended by King Mohammed VI, it said.

The plant will need investments of between 400-500 million euros ($445 million-$557 million).

It is aimed at ensuring vaccine "self-sufficiency" for the North African kingdom, MAP said.

Its goal is to make, between 2022 and 2025, "active substances for more than 20 vaccines, three of which would be against coronavirus... to cover 70 percent of the kingdom's needs and more than 60 percent of needs across Africa", the agency said.

Morocco is already producing the Chinese anti-Covid Sinopharm vaccine, with more than three million doses being made per month.

By next month it plans on producing five million doses and more than 20 million by the end of the year.

Home to 36 million inhabitants, Morocco is hoping that its vaccination drive will help eradicate Covid-19. More than 23 million people have already received a second dose against coronavirus, according to the health ministry.

Authorities hope to vaccinate 80 percent of the population with either Sinopharm or Pfizer-BioNTech.

In July, Recipharm said it had signed a memorandum of understanding with Morocco and a consortium of the country's leading banks to build a factory to produce vaccines and biotherapeutics in the kingdom.

As part of the deal, it said in a statement at the time, $500 million would be invested into the project by the Moroccan government and consortium.

"The investment is primarily to supply the African continent and help it gain vaccine sovereignty and access to future biotherapeutics," it said.

ko-agr/hkb/it

Your State Probably Still Allows Forced Sterilizations

California’s reparations program for forced sterilization survivors is an important step—but it's one of 31 states where this can still legally happen.

By Kylie Cheung

JEZEBEL

Last November, a California judge finally freed Britney Spears from her 13-year-old conservatorship, which was originally put in place because she was deemed mentally unfit to care for herself. Spears testified that during her conservatorship, overseen by her father, she had been forced to keep an IUD in despite wanting to have more children.

“Britney’s experience shocked a lot of people, but the horrible reality is it’s not unusual for guardians to have this power over disabled people’s bodily autonomy and reproductive rights,” Ma’ayan Anafi, senior counsel at the National Women’s Law Center, told Jezebel. “What’s unusual was her platform to share this. Most disabled people don’t get to share their stories of experiences like that, and they go under the radar, not recognized as as a major issue.”

According to a new study from NWLC and Autistic Women and Nonbinary Network (AWN), California is one of 31 states and the District of Columbia that continue to allow nonconsensual sterilizations, particularly targeting disabled and incarcerated people and migrants. At the height of the eugenics movement between 1909 and 1979, there were an estimated 20,000 forced sterilizations in California. During roughly this same period, at least 70,000 people in 32 states were subjected to involuntary sterilizations, primarily targeting Black, Indigenous, Latinx, and disabled people, as well as poor people and migrants.

All of this was legal due to the 1927 Supreme Court case Buck v. Bell, which ruled that the forced sterilization of a young disabled woman was constitutional. For decades, states and the federal government allocated thousands of dollars in public funding toward nonconsensually sterilizing populations deemed “undesirable” by the white supremacist eugenics movement.

Starting Jan. 1, survivors of forced sterilizations in California can apply for compensation from a $4.5 million state fund. California’s reparations program for survivors is an important step in the right direction, but it erroneously implies that involuntary sterilizations can no longer happen in the state. Between 2006 and 2010, doctors in California sterilized almost 150 incarcerated women.

Spears’ conservatorship ended just two months ago. Reports about an ICE doctor performing unwanted hysterectomies on migrant women came out in 2020. Still, we often discuss forced sterilizations as if they’re a relic of the past; this distant framing obscures how they remain legal in most states to this day.

“When you look at ways judges, guardians, and others talk about disabled people today, you see narratives persisting from the eugenics era—that disabled people can’t or shouldn’t make their own decisions about their bodies, that the state needs to make these decisions for their own good, that they’re a burden or threat or drain on the public,” Anafi said.

“Far too many disabled people have survived forced sterilization, which is part of a long, sordid history of forcibly sterilizing disproportionate numbers of Black, Native, Mexican/Chicanx, Japanese and Borikén/Puerto Rican women,” Lydia X. Z. Brown, director of policy, advocacy, and external affairs at AWN, said in a statement. “Unfortunately, not enough people know that forced sterilization is still widespread and completely legal.”

Most states threw out their original sterilization laws from the early 20th century shortly after World War II led to public rejection of Nazi ideas like eugenics. But this only paved the way for “a new type of forced sterilization law” that lets a judge decide whether to sterilize someone who can’t give consent, NWLC and AWN’s report says. These laws were passed relatively recently: California’s current law allowing forced sterilizations approved by judges passed in the 1990s, while the most recent laws took effect in Iowa and Nevada in 2019. Only two states—Alaska and North Carolina—explicitly ban forced sterilizations, while all other states are ambiguous on the issue.

Like Spears, people with or perceived to have disabilities can be legally assigned a conservator or guardian, and lose many of their basic rights and bodily autonomy in the process. NWLC and AWN note that conservators often “decide where they live, who they can be friends with, how to spend their money,” and even “what health care they can get”—they can prohibit someone from having an abortion, and seek the approval of a judge to have someone nonconsensually sterilized.

Despite the popularization of the term “marriage equality,” Anafi says disabled people under conservatorships can lose their right to marry (and vote, and care for their own children, for that matter). Disabled people who do get married can lose government support and other life-saving benefits, which can render them dependent on abusive partners. According to the CDC, disabled people are up to 10 times more likely than non-disabled people to face abuse.

An abusive spouse or partner can notably become a disabled person’s conservator, and ask a judge to approve their disabled partner’s forced sterilization. Reproductive coercion, a form of intimate partner violence, is already more prevalent than many realize in general: 15% of women experiencing physical violence from a male partner also reported birth control sabotage. A quarter of adolescent girls have reported that an abusive male partner attempted to nonconsensually impregnate them by interfering with their contraception. And disabled people are even more vulnerable to reproductive coercion from an intimate partner, especially as they’re often infantilized and denied comprehensive sexual health education and resources.

NWLC and AWN’s research shows traditionally “red” and “blue” states alike still have laws allowing forced sterilizations. Yet the issue slips under the radar at least in part because people of color, disabled people, incarcerated people, migrants, and other marginalized groups who are more likely to be targeted by forced sterilizations aren’t always centered in the reproductive rights movement. Anafi notes that widespread forced sterilization laws and the legal war on abortion rights that’s currently front and center at the Supreme Court “both stem from the same culture and policy landscape of reproductive coercion.”

That policy landscape notably includes abortion bans and restrictions supposedly passed out of concern for people with disabilities or people of color, via so-called sex, race, and disability-selective abortion bans. These laws, in addition to anti-abortion politicians’ racist talking points that call abortion “Black genocide,” allow them to “claim they’re acting on behalf of disabled people, of people of color,” Anafi says, “but they’re really attacking the reproductive rights of disabled people and people of color” by policing their reasons for seeking care.

Following 2020 reports about forced sterilizations at ICE facilities, some anti-abortion politicians and leaders offered hollow condemnations. But their movement draws many of its talking points and racist concerns—like its obsession with perceived threats to the white, American birth rate—from the eugenics movement, which regarded the pregnancies and birth rates of people of color and other “undesirable” populations as an existential threat to white civilization. The white nationalist group Patriot Front attended last week’s March for Life rally, echoing its usual “strong families make strong nations” dog whistle.

Across the country, state and federal lawmakers regularly attempt to write reproductive coercion into the law via abortion restrictions, normalizing similar coercive, abusive behaviors among intimate partners, and among conservators and disabled people. So long as the systematic control of marginalized people’s reproductive lives remains as widely accepted as it is, forced sterilization laws will continue to exist in most states with minimal public awareness or protest.

Since Spears first testified about her conservatorship last summer, her testimony that she was prohibited from having children was a wake-up call for many. Anafi hopes now that Spears is free, the vigilant activism and dedication to disability justice issues that #FreeBritney inspired will continue. “It’s really important we take this moment where people are becoming aware of the issues that those under conservatorships face, and turn it into large-scale change, rethinking all the systems and assumptions that allow disabled people to have their rights taken away.”

Gates Foundation adds more members to its board after the billionaires' divorce

Photo by: Elaine Thompson/AP
In this photo taken Feb. 1, 2019, Bill and Melinda Gates are interviewed in Kirkland, Wash.

By: The Associated Press & Scripps National
Posted Jan 26, 2022

The Bill and Melinda Gates Foundation announced Wednesday that it will add four new members to its board of trustees. It's a first for the Seattle-based philanthropic giant, whose decision making has been guided by very few hands since its incorporation in 2000.

Wednesday's announcement means the global charitable group will now have six people to guide its work and its $50 billion endowment. The new additions include Gates Foundation CEO Mark Suzman and Zimbabwean telecoms billionaire Strive Masiyiwa. Also, the African Union's COVID-19 vaccine envoy, economist Minouche Shafik and Thomas J. Tierney, the co-founder and co-chair of the influential philanthropic consulting firm The Bridgespan Group.

As the Wall Street Journal reports, the changes will allow the organization to add more governance, as well as independence, to the foundation, considered one of the world's largest philanthropic organizations. The Bill and Melinda Gates Foundation has an endowment of over $50 billion.

After their divorce, Bill Gates and Melinda French Gates remained co-chairs, but the foundation has not had additional trustees after the death of Bill Gates Sr. in 2020, and another major donor, Warren Buffett. He resigned in 2021, the Wall Street Journal reported.

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