Saturday, October 12, 2024

 

Research news from the Ecological Society of America’s journals



Ecological Society of America
Zoanthids covering dead coral 

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A new study in Ecosphere suggests that marine animals called zoanthids, seen here blanketing dead coral, can deter reef-eroding urchins (visible at lower right).

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Credit: Patrick Saldaña




The Ecological Society of America (ESA) presents a roundup of four research articles recently published across its esteemed journals. Widely recognized for fostering innovation and advancing ecological knowledge, ESA’s journals consistently feature illuminating and impactful studies. This compilation of papers explores the unique bai ecosystems of central Africa, a potential strategy for managing forests in a more flammable world, the protection of dead corals by secondary reef colonizers and a new approach to examining cause-and-effect relationships in ecology.

 

From Ecology:

Building a baseline for Africa’s bai ecosystems
Author contact: Evan G. Hockridge (evanhockridge@g.harvard.edu)  

Clearings known as “bais” dot the enormous expanse of rainforest extending across central Africa. Although they offer critical habitat for forest elephants, lowland gorillas and a host of other iconic African species, little is known about these canopy gaps. Remote sensing, field surveys and camera traps enabled researchers to document the distribution, abundance and physical properties of these ecosystems in the Congolese Odzala-Kokoua National Park, as well as the plants and animals that frequent them. While more numerous than expected, bais were also generally found to be small, highly clustered and restricted to low-lying areas, thus constituting a rare and unusual forest habitat. Moreover, two different types were identified based on distinguishing features like distinctive soil properties and ecological communities. Given their importance to the biodiversity of the dense forests of Central Africa, these unique ecosystems should be considered areas of high conservation priority, contend the authors.

Read the article: Spatial ecology, biodiversity, and abiotic determinants of Congo’s bai ecosystem

 

From Frontiers in Ecology and the Environment:

Defueling forests may help mitigate future fire
Author contact: Matthew D. Hurteau (mhurteau@unm.edu)  

More frequent applications of prescribed burns could help reduce the growing threat of fire for conifer forests in the western U.S. under a warmer and dryer climate, propose the authors of this study. A legacy of fire exclusion has left many western forests with denser stands than would have occurred historically. Moreover, climate change, pests and pathogens are killing trees in huge numbers, resulting in forests with increasing numbers of dead and stressed trees — woody material that can fuel intense wildfires. Analysis of data collected from prescribed burns in California’s Teakettle Experimental Forest following a 4-year drought suggested that boosting burn rates might help to alleviate the increasing flammability of forests by reducing the volume of accumulated dead fuels. The authors note that prescribed burns are not a silver bullet for forest managers, who will face additional challenges as the climate continues to warm. But the approach has global relevance for the management of forests experiencing similar changes in environmental conditions.

Read the article: Managing fire-prone forests in a time of decreasing carbon carrying capacity

 

From Ecosphere:

Living zoanthid blankets protect dead corals
Author contact: Patrick H. Saldaña (psaldana@ufl.edu)

Dead corals may not be as extravagantly vibrant as live corals, but these ghostly structures still benefit tropical reef inhabitants by serving as physical habitat for other organisms. Yet dead reefs are at greater risk of damage by grazers, including booming populations of urchins. Experiments conducted on reefs off Panama’s Caribbean coast suggested that mats of a species of zoanthid — relatives of sea anemones — can form a protective coating over dead reefs, shielding them from further urchin-induced ruin. Moreover, so effective are these zoanthids “carpets” at deterring urchins that erosion of dead reefs was reduced by up to 50% over a 2-year period in areas where they occurred. The results of their experiments lead the authors to conclude that, by helping to preserve the physical integrity of dead coral structures, coral-associated colonizers like zoanthids may play critical yet largely unrecognized roles in coral reef renewal and recovery.    

Read the article: Friend of the dead: Zoanthids enhance the persistence of dead coral reef framework under high consumer pressure

 

From Ecological Monographs:

A new framework for investigating cause-and-effect in ecological systems
Author contact: James B. Grace (gracej@usgs.gov)

Correlation does not imply causation, as the saying goes, and this is a particular problem in ecology. In many scientific disciplines, cause-and-effect is explored experimentally — alter a variable and see what happens. But when it comes to answering some ecological questions, such as temperature’s role in shaping a plant’s distribution across a continent, controlled manipulations can be impractical or even impossible. In these cases, ecologists often rely on data collected through observation. As the author of this study notes, however, conventional analytical methods are relatively ineffective in teasing out causality from observational data. To address this shortcoming, a novel framework is introduced that rigorously incorporates mechanistic understanding — for instance, the intensity of cold snaps and how much a hard freeze damages a tree’s leaves — to determine causality. The author proposes that adopting a multi-pronged approach to investigating cause-and-effect relationships will greatly enhance understanding of how ecological systems work.

Read the article: An integrative paradigm for building causal knowledge

 

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The Ecological Society of America, founded in 1915, is the world’s largest community of professional ecologists and a trusted source of ecological knowledge, committed to advancing the understanding of life on Earth. The 8,000 member Society publishes seven journals including a membership bulletin and broadly shares ecological information through policy, media outreach and education initiatives. Visit the ESA website at https://www.esa.org

 

The Society’s Annual Meeting attracts 4,000 attendees and features the most recent advances in ecological science. The program and recorded content from last month’s 2024 Meeting in Long Beach, California are available for viewing until summer 2025; members of the press and institutional press officers are invited to contact Public Affairs Manager Mayda Nathan mayda@esa.org for free access.

 

Follow ESA on social media:
Twitter/X – @esa_org
Instagram – @ecologicalsociety
Facebook – @esa.org

 

Novel research suggests quitting smoking may help alleviate opioid crisis



A trailblazing study in the American Journal of Preventive Medicine details the association between smoking and opioid use, emphasizing the need for integrated treatment programs



Peer-Reviewed Publication

Elsevier





Ann Arbor, October 9, 2024 – Smoking is recognized as a leading cause of preventable disability and death. New research shows that as smokers increase their daily number of cigarettes, they report higher rates of chronic pain, more prescription opioid use, severe work limitations due to pain, and poor mental health. A novel study in the American Journal of Preventive Medicine, published by Elsevier, details the results of an analysis of nationally representative data from the US Agency for Healthcare Research and Quality’s Medical Expenditure Panel Survey (MEPS), revealing a strong link between smoking and opioid use and emphasizing the need for integrated treatment programs.

Summarizing key findings, the study’s authors William Encinosa, PhD, Didem Bernard, PhD, and R. Burciaga Valdez, PhD, MHSA, Division of Research and Modeling, Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, and the McCourt School of Public Policy, Georgetown University, say, "Our research shows that adults who smoke 11-20 cigarettes per day use five times more prescription opioids than adults who never smoked. Adults who smoke more than a pack of cigarettes a day use almost three times as many opioids than adults who smoke 11-20 cigarettes per day. Thus, integrating smoking cessation programs into substance use treatments would be a prudent way of reducing prescription opioid use."

The team of researchers analyzed data from 2013 to 2021 from MEPS and the Centers for Disease Control and Prevention’s National Health Interview Survey. Findings show that although only 37% of the population has ever smoked, smokers account for 69% of annual prescription opioid use. Heavy smokers, just 12% of the population, use as many opioids as the 63% who have never smoked. Smokers also report higher rates of chronic pain, severe work limitations due to pain, and poor mental health.

This paper reports the first nationally representative estimates of the association between smoking, pain, and opioid use and how it has persisted from the height of opioid prescription use in 2013 to the recent low in 2021.

Opioid dispensing rates have declined from 81.3 prescriptions per 100 people in 2012 to 43.3 per 100 people in 2020. Many policy factors have led to this decline in opioid prescriptions, such as pill mill laws, state caps on the number of prescriptions per patient, state prescription drug monitoring systems, and the Centers for Disease Control and Prevention guidelines for chronic pain treatment, addressing the concern that high dosages and long-term use of opioids for chronic pain can lead to opioid use disorder and its adverse health outcomes. Despite this decline, there are still prescription opioid hotspots in the US.

The researchers conclude, "Combining smoking cessation with substance abuse treatment could be crucial in addressing the opioid epidemic. Many states and localities are attempting to ban various types of cigarettes. Our research shows that any resulting smoking cessation from these bans may also contribute to easing the opioid crisis."

 

 

 

 WAIT, WHAT?!

Zika virus as a treatment for brain cancer: A systematic review



“Despite limited human evidence, it shows potential benefits.



Impact Journals LLC

Zika virus and brain cancer: Can Zika be an effective treatment for brain cancer? A systematic review 

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Figure 2: Risk of bias for in vivo studies (Robins-I tool).

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Credit: 2024 de Sena Barbosa et al.




“Despite limited human evidence, it shows potential benefits.”

BUFFALO, NY- October 9, 2024 – A new review was published in Oncotarget's Volume 15 on September 30, 2024, entitled, “Zika virus and brain cancer: Can Zika be an effective treatment for brain cancer? A systematic review.”

As highlighted in the introduction of this review, many studies have identified oncolytic viruses as a promising new class of therapeutic agents for central nervous system (CNS) tumors, particularly glioblastomas (GBM). Zika virus (ZIKV) proteins, specifically targeting certain stem cells, have shown promising results in both in vitro and animal model studies.

In their review, researchers Mateus Gonçalves de Sena Barbosa, Beatriz Rodrigues Messias, Rafael Trindade Tatit, Maycon Cristian Gomes de Paula, Valdecir Boeno Spenazato Júnior, Maria Gabriella Borges Braga, Caio Vinícius Marcolino Santos, Luiza D'Ottaviano Cobos, Vinícius Otávio da Silva, Eberval Gadelha Figueiredo, Nicollas Nunes Rabelo, and Bipin Chaurasia from Atenas University Center, PassosUniversity of Israelita de Ciências da Saúde Albert EinsteinUniversity of Sapucaí ValleyAtenas University Center, Sete LagoasNove de Julho University, Campus VergueiroJosé do Rosário Vellano University, AlfenasSchool of Medicine-University of São Paulo (FMUSP), Hospital das Clínicas/FMUSP; and Neurosurgery Clinic in Birgunj, evaluated the efficacy and safety of using ZIKV for treating CNS tumors. Data from in vivo studies were extracted and assessed for bias using the Robins-I tool, evaluating factors such as selection, performance, detection, attrition, and reporting bias.

The 14 studies demonstrated that ZIKV reduced cell viability, inhibited the growth and proliferation of glioma stem cells (GSCs), and decreased Bcl2 expression, potentially enhancing chemotherapy and radiotherapy effects. ZIKV caused cytopathic effects, induced tumor cell damage, showed oncolytic properties, and selectively killed GSCs safely. This ultimately led to significant tumor remission and improved long-term survival through an enhanced T-cell response.

Although current evidence suggests ZIKV as a promising treatment for CNS tumors and may improve survival when combined with surgery and radiotherapy.

Continue reading: DOI: https://doi.org/10.18632/oncotarget.28647

Correspondence to: Bipin Chaurasia - trozexa@gmail.com

Video short: https://www.youtube.com/watch?v=JINORGdqAO4

Keywords: cancer, Zika, neurotropism, glioblastoma, glioma, brain tumor

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About Oncotarget:

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

To learn more about Oncotarget, visit Oncotarget.com and connect with us on social media:

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For media inquiries, please contact media@impactjournals.com.

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Parenting programs help kids, but provide insufficient support for parents, study finds


Research offers insights into how better to support families with young children


McGill University





Parenting programs that address both mental health and parenting skills can improve children’s development, but often fall short when it comes to offering effective mental-health support for parents, new research suggests.

“It’s a surprising contradiction,” said the study’s lead author, Marilyn Ahun, Assistant Professor in the Department of Medicine at McGill University. “Our findings show the potential of multi-component programs, while revealing gaps that need to be addressed.”

The research team reviewed and analysed 25 studies from around the world, in collaboration with colleagues from Harvard, Kuwait and Emory universities.

The researchers, who published their study in The Lancet Child & Adolescent Health, found that children under three whose parents joined integrated programs developed better emotional and cognitive skills, compared to those who received no supports. However, mothers saw little to no relief from their depression symptoms. The authors noted that there are not enough studies assessing depression in fathers to know how programs impact their symptoms.

The insights could help inform the design of programs that better support parents and their young children during a period when children’s brains are most sensitive to experiences, said the researchers. They noted that even if children still benefitted when their parents received support on child-rearing, parental mental health has a strong influence on parenting practices and the outcomes for children.

Gap in mental health support for parents

Programs for parents of young children often address either child-rearing skills or mental health support. In integrated programs that cover both, the primary emphasis is on child-rearing skills, said the authors.

“Many of these programs only dedicate one or two sessions to mental health, which isn’t enough to help parents who are struggling,” said Ahun, who is also a Junior Scientist at the Research Institute of the McGill University Health Centre.

“This is particularly concerning, as about one-in-four mothers and one-in-10 fathers experience depression during the perinatal period, making it difficult for them to provide the nurturing support their children need,” she added.

With more than 250 million children worldwide falling short of their developmental potential, the researchers say their findings offer insights into how best to improve family support during a critical phase of early-childhood development. 

 

Study probes how eating less can extend lifespan



Researchers at The Jackson Laboratory conduct pivotal study into aging and lifespan to uncover new details about how diets might make people live longer — but also their negative side effects.



Jackson Laboratory

Genetic diversity key to The Jackson Laboratory longevity study. 

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A graphic representing the power of genetic diversity in mice to study longevity and healthspan.

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Credit: The Jackson Laboratory




For nearly a century, laboratory studies have shown consistent results: eat less food, or eat less often, and an animal will live longer. But scientists have struggled to understand why these kinds of restrictive diets work to extend lifespan, and how to best implement them in humans. Now, in a long-awaited study to appear in the Oct. 9 issue of Nature, scientists at The Jackson Laboratory (JAX) and collaborators tracked the health of nearly one thousand mice on a variety of diets to make new inroads into these questions.

The study was designed to ensure that each mouse was genetically distinct, which allowed the team to better represent the genetic diversity of the human population. By doing so, the results are made more clinically relevant, elevating the study to one of the most significant investigations into aging and lifespan to date.

The study concluded that eating fewer calories had a greater impact on lifespan than periodic fasting, revealing that very-low-calorie diets generally extended the mice’s lifespan regardless of their body fat or glucose levels — both typically seen as markers of metabolic health and aging. Surprisingly, the mice that lived the longest on the restrictive diets were those that lost the least weight despite eating less. Animals that lost the most weight on these diets tended to have low energy, compromised immune and reproductive systems, and shorter lives.

“Our study really points to the importance of resilience,” said Gary Churchill, Karl Gunnar Johansson Chair and professor at JAX who led the study. “The most robust animals keep their weight on even in the face of stress and caloric restriction, and they are the ones that live the longest. It also suggests that a more moderate level of calorie restriction might be the way to balance long-term health and lifespan.”

Churchill and his colleagues assigned female mice to any of five different diets: one in which the animals could freely eat any amount of food at any time, two in which the animals were provided only 60% or 80% of their baseline calories each day, and two in which the animals were not given any food for either one or two consecutive days each week but could eat as much as they wanted on the other days. Then, the mice were studied for the rest of their lives with periodic blood tests and extensive evaluation of their overall health.

Overall, mice on unrestricted diets lived for an average of 25 months, those on the intermittent fasting diets lived for an average of 28 months, those eating 80% of baseline lived for an average of 30 months, and those eating 60% of baseline lived for 34 months. But within each group, the range of lifespans was wide; mice eating the fewest calories, for example, had lifespans ranging from a few months to four and a half years.

When the researchers analyzed the rest of their data to try to explain this wide range, they found that genetic factors had a far greater impact on lifespan than diets, highlighting how underlying genetic features, yet to be identified, play a major role in how these diets would affect an individual person’s health trajectory. Moreover, they pinpointed genetically-encoded resilience as a critical factor in lifespan; mice that naturally maintained their body weight, body fat percentage and immune cell health during periods of stress or low food intake, as well as those that did not lose body fat late in life, survived the longest.

“If you want to live a long time, there are things you can control within your lifetime such as diet, but really what you want is a very old grandmother,” Churchill said.

The study also cast doubt on traditional ideas about why certain diets can extend life in the first place. For example, factors like weight, body fat percentages, blood glucose levels and body temperature did not explain the link between cutting calories and living a longer life.  Instead, the study found that immune system health and traits related to red blood cells were more clearly connected to lifespan. Importantly, those findings mean that human studies of longevity – which often use metabolic measurements as markers for aging or youthfulness – may be overlooking more important aspects of healthy aging.

“While caloric restriction is generally good for lifespan, our data show that losing weight on caloric restriction is actually bad for lifespan,” Churchill explained. “So when we look at human trials of longevity drugs and see that people are losing weight and have better metabolic profiles, it turns out that might not be a good marker of their future lifespan at all.”

 

 

Consumer Food Insights Report highlights increasing use of food-ordering apps



Survey shows food spending per person has increased 15% since January 2022



Purdue University

Purdue agricultural economist Joseph Balagtas 

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In the latest Consumer Food Insights Report, Joseph Balagtas, professor of agricultural economics at Purdue University and director of the Center for Food Demand Analysis and Sustainability, explored consumers’ online food ordering app usage. (Purdue Agricultural Communications photo/Kate Jacobson)

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Credit: Purdue Agricultural Communications photo/Kate Jacobson






WEST LAFAYETTE, Ind. — Around two-thirds of consumers have used a food-ordering app at least once for takeout, delivery or both, according to the September 2024 Consumer Food Insights Report (CFI). Over half have used an app for a delivery order. Of those who say they have used an app to order food, nearly half report using one for either delivery or takeout at least once a week.

The survey-based report out of Purdue University’s Center for Food Demand Analysis and Sustainability(CFDAS) assesses food spending, consumer satisfaction and values, support of agricultural and food policies, and trust in information sources. Purdue experts conducted and evaluated the survey, which included 1,200 consumers across the U.S.

“The COVID-19 pandemic changed the economy in many ways, particularly in the service economy,” said the report’s lead author, Joseph Balagtas, professor of agricultural economics at Purdue and director of CFDAS. 

Earlier this year, the U.S. Department of Agriculture (USDA) reported that spending on food-ordering apps for deliveries from full-service restaurants quadrupled between prepandemic months and 2022. The trend prompted the CFDAS team to partner with Valerie Kilders, assistant professor of agribusiness marketing at Purdue, to measure and evaluate consumer usage of the apps.

When ordering food online, 68% of consumers say they “sometimes,” “often” or “always” use discounts or promo codes.

Food purchased away from home is typically more costly than food prepared at home with groceries. Understandably, many consumers seek cost reductions when paying for the convenience of a prepared meal, Balagtas said. This is particularly true for consumers who spend the least on food. Half of them used discounts and promo codes “often” or “always” when ordering food online. 

The report breaks down per-person weekly food expenditure [BDS1] [EHB2] into three groups: thrifty (less than $50 a week), moderate ($50 to $85 a week) and liberal (more than $85 a week) spenders. “Consumers who spend the most on food tend to seek out discounts less frequently,” Balagtas said.

The CFI survey also asked consumers about the additional fees associated with many food-ordering apps. Many attribute the fee to operating expenses of the service, whether it’s to cover fuel and time for delivery services or administration and maintenance of the app itself.

The survey further revealed that on average, consumers say they tip between 10% and 19% for a food delivery order. “Interestingly, 15% say they tip less than 10% of the total order, and 14% say they do not tip at all for this service,” Balagtas said. “We see little difference in the tipping percentages when disaggregating the responses by per-person weekly food spending.”

The sustainable food purchasing index remained unchanged from the CFI survey’s last assessment in June 2024. 

“Consumers continue to purchase food that they feel is safe and fits their tastes, budgets and nutritional needs,” said Elijah Bryant, a survey research analyst at CFDAS and a co-author of the report. And fewer of them currently buy or plan to buy foods with environmental and social sustainability in mind.

“Even though consumers may value the environmental impact and social responsibility of their food, when it comes to purchasing factors, more immediate priorities like food security, taste, economic factors and nutrition drive their decisions,” he said.

Since its inception in January 2022, the CFI survey has documented a gradual positive trend in per-person weekly food expenditures. In January 2022, the figure was around $72. Last month, consumers reported an average per-person weekly spending total of $83, a 15% increase.

“Consumers are having to adjust their budgets to accommodate higher food prices to purchase the same groceries,” Bryant said. “Wage growth will be a key determinant in food purchasing behavior changes as food prices remain higher after inflation spiked in 2022.”

Based on the USDA’s questionnaire for measuring food insecurity, the CFDAS researchers estimate the national food insecurity rate to be 13%, unchanged from last month. The rate of food insecurity is highest among households that spend less than $50 on food per person per week.

“We have seen a clear correlation between income and food security in the past and see that many households that spend less on food are likely doing so due to income constraints,” Bryant said. Around 29% said they use free food resources, such as food banks, to supplement their diets. This shows the importance of these resources for people who struggle with food insecurity due to a lower food budget, he said.

Around 14% of thrifty food spenders adhere to either a vegetarian or vegan diet, relative to just 6% of moderate and liberal food spenders. Thrifty spenders also report growing their own food in either a home or community garden at a higher rate (32%) than moderate (24%) and liberal (21%) food spenders.

“We do not observe many substantial differences in the frequency of a variety of surveyed food behaviors between the spending groups,” Bryant said.

“However, we do observe thrifty food spenders choosing generic foods over brand-name foods more frequently than moderate and liberal spenders,” he said. In line with the larger share of vegans and vegetarians in the thrifty group, they are also more likely to choose plant-based proteins over animal proteins.

The Center for Food Demand Analysis and Sustainability is part of Purdue’s Next Moves in agriculture and food systems and uses innovative data analysis shared through user-friendly platforms to improve the food system. In addition to the Consumer Food Insights Report, the center offers a portfolio of online dashboards.

Writer: Steve Koppes

 

About Purdue Agriculture
Purdue University’s College of Agriculture is one of the world’s leading colleges of agricultural, food, life and natural resource sciences. The College is committed to: preparing students to make a difference in whatever careers they pursue; stretching the frontiers of science to discover solutions to some of our most pressing global, regional and local challenges; and, through Purdue Extension and other engagement programs, educating the people of Indiana, the nation and the world to improve their lives and livelihoods. To learn more about Purdue Agriculture, visit this site.

 

About Purdue University

Purdue University is a public research institution demonstrating excellence at scale. Ranked among top 10 public universities and with two colleges in the top four in the United States, Purdue discovers and disseminates knowledge with a quality and at a scale second to none. More than 105,000 students study at Purdue across modalities and locations, including nearly 50,000 in person on the West Lafayette campus. Committed to affordability and accessibility, Purdue’s main campus has frozen tuition 13 years in a row. See how Purdue never stops in the persistent pursuit of the next giant leap — including its first comprehensive urban campus in Indianapolis, the Mitch Daniels School of Business, Purdue Computes and the One Health initiative — at https://www.purdue.edu/president/strategic-initiatives

 

How do Americans use food-ordering applications? 

How do consumers interact with food ordering applications?