Monday, April 14, 2025

 

Learning about social interaction by studying dancing



Brain activity that enables people to align their movements with others is present only when dancers move to the beat of the same song and can see each other.


Society for Neuroscience




Dancing fluidly with another involves social coordination. This skill entails aligning movements with others while also processing dynamic sensory information, like sounds and visuals. In a new JNeurosci paper, Félix Bigand and Giacomo Novembre, from the Italian Institute of Technology, Rome, and colleagues report their findings on how the brain drives social coordination during dance.  

The researchers recruited pairs of inexperienced dancers and recorded their brain activity, whole-body movements, and muscle activity as they danced to the same or different songs. The researchers also manipulated whether dancers could or could not see each other. These methods unveiled distinct neural signals for music processing, self-generated movements, movements generated by following a partner, and social coordination. Neural signals for social coordination that enabled synchronized movements between people occurred only when dancers were moving to the same song and could see each other. Says Bigand, “What was perhaps most peculiar was we found that out of the 15 different movements we recorded, the brain was most sensitive to bouncing or flexing of the knees [during social coordination]. This was strange because bouncing had relatively weak amplitudes [or strength] compared to most of the other movements. For the brain to respond more to a weaker movement, like bounce, suggests it has a unique role in social coordination.”  

According to the authors, this work advances our understanding of social interaction beyond dancing because it sheds light on how the brain supports socially engaging activities while integrating dynamic sensory information. Bigand also emphasizes that the methods used to unravel distinct neural signals for different kinds of sensory information processing may improve the applicability of future preclinical work to reality. 

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Please contact media@sfn.org for full-text PDF. 

About JNeurosci 

JNeurosci was launched in 1981 as a means to communicate the findings of the highest quality neuroscience research to the growing field. Today, the journal remains committed to publishing cutting-edge neuroscience that will have an immediate and lasting scientific impact, while responding to authors' changing publishing needs, representing breadth of the field and diversity in authorship. 

About The Society for Neuroscience 

The Society for Neuroscience is the world's largest organization of scientists and physicians devoted to understanding the brain and nervous system. The nonprofit organization, founded in 1969, now has nearly 35,000 members in more than 95 countries. 

 

 

New study finds surprising way to curb college-aged drinking harms—without cutting alcohol



A complementary approach called Counter-Attitudinal Advocacy has been found to help young adults reduce the harms related to heavy drinking by shifting how they think—not how much they drink



Brown University




Young adults—particularly college students—are more likely than any other group in the U.S. to engage in heavy drinking and experience alcohol-related consequences.

The consequences of heavy drinking—which is defined as four or more drinks per occasion for women and five or more for men—are felt throughout the college community. These include blackouts, academic underperformance and interpersonal problems. Then there are the secondhand consequences for students who don’t drink, such as interrupted study, aggression, assault and having to care for intoxicated peers.

In a new study, researchers from the Brown University School of Public Health developed and tested an intervention called Counter-Attitudinal Advocacy (CAA). CAA involves advocating for a position that contradicts a personally held attitude or behavior. In this context, CAA targets positive perceptions of heavy drinking and the belief that alcohol is an essential part of college life.

In randomized controlled trials at two sites with 585 college students, researchers compared CAA to the well-established Personalized Normative Feedback (PNF) to evaluate their effectiveness in decreasing drinks per week, peak blood alcohol concentration and alcohol-related consequences relative to a control group. Researchers focused on drinks per week, a standard measure given the irregular drinking patterns of college students, who often veer between heavy drinking and alcohol-free days.

Ultimately, they worked on answering two main questions:

  • Does CAA effectively reduce alcohol-related risk compared to our control?
  • How does CAA compare to PNF, which has proven to be an effective low-cost way of reducing alcohol consumption among high-risk students?

Here’s what they found: Participants who received PNF reported significantly fewer drinks per week than the control group, while those who received CAA reported significantly fewer consequences. CAA had a harm reduction effect on consequences—its intended focus—but not on consumption of alcohol, which it did not target.

“Both interventions take just 5–10 minutes, making them ideal for broad prevention efforts,” said Kate Carey, co-lead investigator of the study and professor of behavioral and social sciences at Brown. “Our results showed that PNF did reduce alcohol consumption, as expected. But CAA specifically reduced the number of problems participants reported due to drinking. So, while they had different effects, they were complementary—giving us another useful tool for harm reduction.”

Carey explained that PNFs show participants how their drinking habits stack up against those of their peers, often exposing a common misconception that others drink more than they actually do: an insight that can help them adjust their own behavior. In contrast, CAA encourages participants to reflect on why it is a good idea to avoid alcohol-related problems, such as passing out or taking excessive risks, and to identify specific actions they can take to minimize these risks.

“Instead of directly telling students what to do, we prompt them to generate their own strategies,” Carey said. “This makes the intervention personalized and non-confrontational. Unlike some interventions that make people feel defensive about their drinking, CAA frames the discussion more broadly: ‘Why is it good for young people to avoid problems?’ rather than ‘You personally need to change.’”

As participants responded to these prompts, a research assistant or peer asked them to explain their written responses. Carey noted that this act of verbal reinforcement likely strengthened the intervention’s effect, since we tend to feel more committed to our viewpoints when we share them publicly.

It’s important to have a variety of brief interventions, since no single approach works for everyone, Carey stressed. Offering multiple evidence-based options increases the chances of reaching more people who are undergoing a period of heightened risk. 

The research team, which includes co-primary investigators Angelo DiBello associate professor of applied and professional psychology at Rutgers University and Clayton Neighbors, professor of social psychology at the University of Houston, are encouraged that CAA provides another effective tool—especially for those who may not respond to PNF.

 

Understanding vicarious trauma in research assistant roles


Rutgers Health study emphasizes the importance of building in breaks and fostering supportive, flexible team environments




Rutgers University




Research assistants often face unique challenges when working on emotionally intense topics, particularly if they lack established support systems outside the research team or have not yet learned effective coping strategies, according to a Rutgers Health study.

The study, published in the Journal of Gender-Based Violence, surveyed 27 research assistants involved in a multistate firearm violence research project. While working on the project, research assistants read and coded graphic descriptions of gun violence.

According to the findings, 26% of research assistants lacked reliable emotional support outside of their research teams. Among the coping strategies reported, the most common were taking short breaks (89%) and engaging in informal peer interactions (41%), with 83% and 91% of research assistants, respectively, finding these strategies helpful.

The study emphasizes the importance of building emotional breaks and fostering supportive, flexible team environments.

“Gun violence prevention work can involve emotionally difficult topics such as suicide, intimate partner abuse and more,” said Jennifer Paruk, a postdoctoral fellow at the New Jersey Gun Violence Research Center at the Rutgers School of Public Health.

Paruk, the lead author of the study, said some research assistants “may be encountering these issues for the first time – and in an intense way – through their research roles. Many are also living away from home and without their usual support systems, which can make coping even more difficult.”

The study highlighted that taking short breaks between Extreme Risk Protection Order cases helped research assistants reset and regain focus. Informal peer interactions also were a key coping tool, providing opportunities for shared strategies and emotional connection. These conversations created a space for mutual validation and support, helping research assistants process the emotional weight of their work.

“There are many ways that study teams can support their research assistants, regardless of the team’s structure or needs,” Paruk said.

Explore more of the ways Rutgers research is shaping the future.

 

Researchers develop an LSD analogue with potential for treating schizophrenia




University of California - Davis
Researchers Develop an LSD Analogue with Potential for Treating Schizophrenia 

image: 

A cortical neuron treated with JRT, a synthetic molecule similar to the psychedelic drug LSD. Drugs like JRT might enable new treatments for conditions such as schizophrenia, without the hallucinations and other side effects of psychedelics. 

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Credit: Lee Dunlap, UC Davis Institute for Psychedelics and Neurotherapeutics




University of California, Davis researchers have developed a new, neuroplasticity-promoting drug closely related to LSD that harnesses the psychedelic’s therapeutic power with reduced hallucinogenic potential.

The research, published in Proceedings of the National Academy of Sciences, highlights the new drug’s potential as a treatment option for conditions like schizophrenia, where psychedelics are not prescribed for safety reasons. The compound also may be useful for treating other neuropsychiatric and neurodegenerative diseases characterized by synaptic loss and brain atrophy.

To design the drug, dubbed JRT, researchers flipped the position of just two atoms in LSD’s molecular structure. The chemical flip reduced JRT’s hallucinogenic potential while maintaining its neurotherapeutic properties, including its ability to spur neuronal growth and repair damaged neuronal connections that are often observed in the brains of those with neuropsychiatric and neurodegenerative diseases.

“Basically, what we did here is a tire rotation,” said corresponding author David E. Olson, director of the Institute for Psychedelics and Neurotherapeutics and a professor of chemistry, and biochemistry and molecular medicine at UC Davis. “By just transposing two atoms in LSD, we significantly improved JRT’s selectivity profile and reduced its hallucinogenic potential.”

JRT exhibited powerful neuroplastic effects and improved measures in mice relevant to the negative and cognitive symptoms of schizophrenia, without exacerbating behaviors and gene expression associated with psychosis.

“No one really wants to give a hallucinogenic molecule like LSD to a patient with schizophrenia,” said Olson, who is also co-founder and chief innovation officer of Delix Therapeutics, a company that aims to bring neuroplastogens to the market. “The development of JRT emphasizes that we can use psychedelics like LSD as starting points to make better medicines. We may be able to create medications that can be used in patient populations where psychedelic use is precluded.”

Testing JRT’s potential

Olson said that it took his team nearly five years to complete the 12-step synthesis process to produce JRT. The molecule was named after Jeremy R. Tuck, a former graduate student in Olson’s laboratory, who was the first to synthesize it and is a co-first author of the study along with Lee E. Dunlap, another former graduate student in Olson’s laboratory.

Following JRT’s successful synthesis, the researchers conducted a battery of cellular and mouse assays that demonstrated the drug’s neuroplastic effects and improved safety profile relative to LSD.

Key findings included:

  • JRT and LSD have the exact same molecular weight and overall shape, but distinct pharmacological properties.
  • JRT is very potent and highly selective for binding to serotonin receptors, specifically 5-HT2A receptors, the activation of which are key to promoting cortical neuron growth.
  • JRT promoted neuroplasticity, or growth between cellular connections in the brain, leading to a 46% increase in dendritic spine density and an 18% increase in synapse density in the prefrontal cortex.
  • JRT did not produce hallucinogenic-like behaviors that are typically seen when mice are dosed with LSD.
  • JRT did not promote gene expression associated with schizophrenia. Such gene expression is typically amplified with LSD use.
  • JRT produced robust anti-depressant effects, with it being around 100-fold more potent than ketamine, the state-of-the-art fast-acting anti-depressant.
  • JRT promoted cognitive flexibility, successfully addressing deficits in reversal learning that are associated with schizophrenia.

“JRT has extremely high therapeutic potential. Right now, we are testing it in other disease models, improving its synthesis, and creating new analogues of JRT that might be even better,” Olson said.

A more effective treatment for schizophrenia

Olson emphasized JRT’s potential for treating the negative and cognitive symptoms of schizophrenia, as most current treatments produce limited effects on anhedonia — the inability to feel pleasure — and cognitive function. Clozapine is the one exception, but it has side effects, and is not first-line drug of choice for people severely afflicted with schizophrenia.

Olson and his team are currently testing JRT’s potential against other neurodegenerative and neuropsychiatric diseases.

Additional coauthors include Yara A. Khatib, Cassandra J. Hatzipantelis, Sammy Weiser Novak, Rachel M. Rahn, Alexis R. Davis, Adam Mosswood, Anna M. M. Vernier, Ethan M. Fenton, Isak K. Aarrestad, Robert J. Tombari, Samuel J. Carter, Zachary Deane, Yuning Wang, Arlo Sheridan, Monica A. Gonzalez, Arabo A. Avanes, Noel A. Powell, Milan Chytil, Sharon Engel, James C. Fettinger, Amaya R. Jenkins, William A. Carlezon Jr., Alex S. Nord, Brian D. Kangas, Kurt Rasmussen, Conor Liston and Uri Manor.

The research reported on here was funded by grants from the National Institutes of Health, the UC Davis Provost’s Undergraduate Fellowship, the Camille and Henry Dreyfus Foundation, the Dr. Mohsen Najafi Research Award in Medicinal Chemistry, the Boone Family Foundation, Hope for Depression Research Foundation, the Pritzker Neuropsychiatric Disorders Research Consortium, the L.I.F.E. Foundation, the Chan-Zuckerberg Initiative Imaging Scientist Award, and a National Science Foundation NeuroNex Award.


A cortical neuron treated with JRT, a synthetic molecule similar to the psychedelic drug LSD. Drugs like JRT might enable new treatments for conditions such as schizophrenia, without the hallucinations and other side effects of psychedelics. 

Credit

Lee E. Dunlap, UC Davis Institute for Psychedelics and Neurotherapeutics

 

Archaeologists discover historical link between inequality and sustainability




Durham University




The study lead by Professor Dan Lawrence, of Durham University in the UK, found that across ten millennia, more unequal distributions of wealth correlated with longer-term human settlement. 

However, the team are keen to stress that one factor is not causally dependent on the other, giving hope that humankind’s survival is not linked to ever increasing inequality.

The research is part of a Special Feature of the Proceedings of the National Academy of Sciences (PNAS), entitled Global Dynamics of Wealth Inequality.

Sustainability is defined by the UN as ‘meeting the needs of the present without compromising the ability of future generations to meet their own needs’. The study investigated the relationship the two key aspects of this definition, continuity and equality.

The team used data on house size from across the world, covering the last 10,000 years, analysing records of over 47,500 homes across over 2,990 archaeological sites.

Differences in house size were used as a measure of inequality during different time periods. This data was then analysed alongside information on the duration of occupation, in simple terms how long people lived in a settlement before it was abandoned.

The findings revealed a correlation between the two measures – with more unequal settlements (as measured through house sizes) tending to persist for longer. However, this relationship was not found to be causal, and instead both factors rose with the increased scale and complexity of human systems. 

The research team believe the findings could help inform interventions to improve future sustainability.

Speaking about the research, Professor Dan Lawrence, Department of Archaeology at Durham University said: “The UN definition of sustainability references our societies not only continuing to exist but becoming more equal.

“We wanted to understand the relationship between those two aspects and ask whether equality or inequality is historically more sustainable.

“What we found is that, as humankind’s systems become larger and more complex, inequality has tended to increase alongside longer persistence. But the two are not mutually dependant, showing that humankind might be able to achieve sustainable persistence without the need for increased inequality.

“It is not the case that inequality is simply a necessary by-product of building complex, sustainable societies.

“We need to be aware of, and attentive to the historical interplay between inequality and sustainability.

“At a time of ever-increasing wealth inequality and sustainability challenges including climate change, the lessons from the past 10,000 years could be invaluable for helping us to achieve a more equal, truly sustainable future.”

The study was authored by researchers from across Europe and the USA, drawing on a database collected by archaeologists from across the world. It is published as part of a special feature of PNAS, which has examined the origins and drivers of inequality from multiple angles.

Each of the studies has utilised a specially compiled data set on house sizes across the world from the last 10,000 years, as well as information on societies across time, such as structures, hierarchies, agriculture etc.

Professor Dan Lawrence, Department of Archaeology, Durham, has also been co-author on eight other papers as part of this special feature.

ENDS

New study reveals wealth inequality’s deep roots in human prehistory




Washington State University





PULLMAN, Wash. — Wealth inequality began shaping human societies more than 10,000 years ago, long before the rise of ancient empires or the invention of writing.

That’s according to a new study led by Washington State University archaeologist Tim Kohler that challenges traditional views that disparities in wealth emerged suddenly with large civilizations like Egypt or Mesopotamia. The research is part of a special issue of the Proceedings of the National Academy of Sciences, co-edited by Kohler and Amy Bogaard, an archaeologist at Oxford University in England.

Drawing on data from over 47,000 residential structures across 1,100 archaeological sites worldwide, the researchers used house sizes as a measure of wealth. Their analysis shows that wealth inequality started to increase roughly 1,500 years after the advent of agriculture in different civilizations across the world. This effect was driven by population growth, competition for land and the development of hierarchical settlements.

“Many people imagine early societies as egalitarian, but our research shows wealth inequality took root surprisingly early,” said Kohler. “The shift wasn’t instantaneous. It grew gradually as societies expanded, populations increased and resources became more constrained.”

The study highlights several key factors contributing to inequality. As farming communities grew, land became a finite resource, leading to competition and innovations like terracing and irrigation to boost productivity. Over time, larger settlements emerged as hubs of economic and political activity, where wealth began to concentrate in the hands of a few households. These wealth disparities were particularly evident in high population settlements, which exhibited greater inequality than smaller communities.

Tim Kohler

One of the study’s significant revelations is that wealth inequality predates written records, with evidence showing disparities existed even in the earliest agricultural societies. By applying the Gini coefficient—a standard measure of inequality—to ancient house sizes, researchers discovered that early farming villages were relatively egalitarian. However, as settlements became larger and more complex, economic disparities grew.

The study also challenges the idea that preindustrial societies lived in a “Malthusian world” of subsistence-level existence. Instead, Kohler and his team found evidence of steady wealth accumulation and technological advancements over millennia. The researchers point out that early agricultural societies often modified their landscapes—building terraces, draining wetlands, or creating irrigation systems—to intensify production. These innovations increased productivity but also widened the gap between those who controlled resources and those who did not.

Interestingly, the research revealed that some innovations, like iron smelting, often reduced inequality by increasing access to tools and resources for lower social strata. This finding challenges the assumption that technological advances always benefit elites. Kohler also noted that other factors, like the presence of large governing systems or collaborative social networks, played a role in mitigating or amplifying inequality over time.

“This isn’t just a modern problem,” Kohler said. “Understanding the origins of wealth inequality helps us see it as a persistent challenge that societies have been grappling with for thousands of years. The past has much to teach us about navigating these issues today.”

The study was a collaborative effort involving 27 researchers from institutions worldwide and was coordinated by the Coalition for Archaeological Synthesis, a not-for-profit organization dedicated to synthesizing the archaeological record to advance science and benefit society. By focusing on the period before written records, the researchers hope to fill a critical gap in understanding how human societies evolved, from egalitarian hunter-gatherer groups to complex, hierarchical communities.

“These patterns are deeply embedded in our history,” Kohler said. “But by studying them, we can better address their implications for the future. If we can understand how inequality emerged and evolved, perhaps we can learn how to mitigate its impact today.”