Showing posts sorted by relevance for query KOBE. Sort by date Show all posts
Showing posts sorted by relevance for query KOBE. Sort by date Show all posts

Saturday, December 23, 2023

 

Pancake stack of films on a balloon most accurate gamma-ray telescope


Peer-Reviewed Publication

KOBE UNIVERSITY

Aoki Vela Collage 

IMAGE: 

A SINGLE PANCAKE MAY CAPTURE WHERE YOU POKE A STRAW INTO IT, BUT IT TAKES A WHOLE STACK TO RECORD THE STRAW'S DIRECTION. SIMILARLY, KOBE UNIVERSITY RESEARCHERS COULD ACCURATELY IMAGE A GAMMA-RAY-EMITTING PULSAR (THE SKY’S LIGHTHOUSES) WITH A STACK OF RADIOACTIVITY-SENSITIVE FILMS ON A BALLOON. TO BE ABLE TO TELL THE ORIENTATION OF THE DANGLING GONDOLA RELATIVE TO THE STARS, THEY ADDED A STAR CAMERA AND A DEVICE TO TIMESTAMP THE GAMMA-RAYS’ IMPACTS.

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CREDIT: KOBE UNIVERSITY




A pancake stack of radioactivity-sensitive films carried through the sky by a balloon was able to take the world's most accurate picture of a neutron star's gamma ray beam. To achieve this, Kobe University researchers combined the oldest method of capturing radioactive radiation with the newest data capturing techniques and a clever time-recording device.

The stars shine their light on us in the full range of the spectrum of light, from infra-red to gamma rays. For each of these bands, different sensing equipment is needed. The most challenging one is gamma rays, famous for being a high-energy product of nuclear fission, because their very short wavelength means that they don't interact with matter in the same way as other forms of light and thus can't be deflected with lenses or detected by standard sensors. Thus, there is a gap in our ability to detect the light coming from fascinating stellar objects such as supernovae and their remnants.

To resolve this issue, Kobe University astrophysicist AOKI Shigeki and his team turned to the very first material that was used to detect radioactivity, photographic films. "Our group has been focusing on the excellent capability of emulsion film to trace gamma rays with high precision and proposed that it could become an excellent gamma-ray telescope by introducing several modern data capture and analysis features," explains Aoki. Based on the high sensitivity of these films and a novel, automated, high-speed process of extracting data from them, the physicists' idea was to stack up a few of them to accurately capture the trajectory of the particles that the gamma ray produces on impact, just like a single pancake may capture where you poke a straw into it, but it takes a whole stack to record the straw's direction.

To reduce atmospheric interference, they then mounted the stack of films onto a scientific observation balloon to lift it to a height between 35 and 40 kilometers. However, since a balloon is swaying and twisting in the wind, the direction of the "telescope" is not stable, so they added a set of cameras to record the gondola's orientation relative to the stars at any time. But this created another issue, because as anybody who has ever taken a photograph with long exposure knows, photographic film does not record the passage of time and so it is not directly possible to know at what time any given gamma ray impact occurred. To overcome this problem, they made the bottom three layers of film move back and forth at regular but different speeds, just like the hands of a clock. From the relative dislocation of the traces in those lower plates they could then calculate the precise time of the impact and thus correlate it with the cameras' footage.

They have now published the first image resulting from this setup in the journal The Astrophysical Journal. It is the most accurate image ever produced of the Vela pulsar, a fast-spinning neutron star that projects a beam of gamma rays into the sky like a lighthouse at night. "We captured a total of several trillion tracks with an accuracy of 1/10,000 millimeters. By adding time information and combining it with attitude monitoring information, we were able to determine ‘when’ and ‘where’ the events originated with such precision that the resulting resolution was more than 40 times higher than that of conventional gamma-ray telescopes," Aoki summarizes his group's achievements.

While these results are impressive already, the new technique opens the possibility of capturing more details in this frequency band of light than ever before. The Kobe University researcher explains, "By means of scientific balloon-borne experiments, we can attempt to contribute to many areas of astrophysics, and in particular to open up gamma-ray telescopy to 'multi-messenger astronomy' where simultaneous measurements of the same event captured through different techniques are required. Based on the success of the 2018 balloon experiment these data were generated with, we will expand the observation area and time in upcoming balloon flights and are looking forward to scientific breakthroughs in the field of gamma-ray astronomy."

This work was supported by JSPS KAKENHI grants 17H06132, 18H01228 and 18K13562. It was conducted in collaboration with researchers from Okayama University of Science, Aichi University of Education, Nagoya University and Gifu University.

Kobe University is a national university with roots dating back to the Kobe Commercial School founded in 1902. It is now one of Japan's leading comprehensive research universities with nearly 16,000 students and nearly 1,700 faculty in 10 faculties and schools and 15 graduate schools. Combining the social and natural sciences to cultivate leaders with an interdisciplinary perspective, Kobe University creates knowledge and fosters innovation to address society’s challenges.

The balloon carrying the gondola with the telescope takes off from Alice Springs, Australia.

A section of the emulsion film after development. The traces of the particles produced by gamma ray impacts can be seen as tiny greyish dots throughout the plane.

The image of the Vela pulsar. The image has a resolution more than 40 times better than what could be achieved previously: The circle at the bottom left indicates the pulsar’s image spread for comparison with the image spread of the previously best gamma ray image (of a different stellar object), indicated by the dashed circle.

CREDIT

GRAINE collaboration

Wednesday, January 31, 2024

 

Structural color ink: Printable, non-iridescent and lightweight


Peer-Reviewed Publication

KOBE UNIVERSITY

Sugimoto Nanospheres Color Tilt 

VIDEO: 

A SINGLE LAYER OF SILICON NANOSPHERES PRODUCES BRIGHT STRUCTURAL COLORS THAT ARE INDEPENDENT OF THE VIEWING ANGLE. THE COLOR CAN BE CONTROLLED BY THE DIAMETER OF THE SPHERES, WHERE SMALLER PARTICLES ARE BLUER AND LARGER ONES REDDER.

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CREDIT: FUJII MINORU




A new way of creating color uses the scattering of light of specific wavelengths around tiny, almost perfectly round silicon crystals. This Kobe University development enables non-fading structural colors that do not depend on the viewing angle and can be printed. The material has a low environmental and biological impact and can be applied extremely thinly, promising significant weight improvements over conventional paints.

An object has color when light of a specific wavelength is reflected. With traditional pigments, this happens by molecules absorbing other colors from white light, but over time this interaction makes the molecules degrade and the color fades. Structural colors, on the other hand, usually arise when light is reflected from parallel nanostructures set apart at just the right distance so that only light of certain wavelengths will survive while others are cancelled out, reflecting only the color we see. This phenomenon can be seen in wings of butterflies or feathers of peacocks, and has the advantage that the colors don't degrade. But from an industrial point of view, neatly arranged nanostructures cannot be painted or printed easily, and the color depends on the viewing angle, making the material iridescent.

Kobe University material engineers FUJII Minoru and SUGIMOTO Hiroshi have been developing an entirely new approach to producing colors. They explain, “In previous work since 2020, we were the first to achieve precise particle size control and develop colloidal suspensions of spherical and crystalline silicon nanoparticles. These single silicon nanoparticles scatter light in bright colors by the phenomenon of ‘Mie resonance,’ which allows us to develop structural color inks.” With Mie resonance, spherical particles of a size comparable to the wavelength of light reflect specific wavelengths particularly strongly. This means that the color that mainly comes back from the suspension can be controlled simply by varying the size of the particles.

In their work now published in the journal ACS Applied Nano Materials, Fujii and Sugimoto demonstrate that the suspension can be applied to surfaces and will thus coat the underlying material in a form of structural color that does not depend on the viewing angle. This is because the color is not produced by the interaction of light reflected from neighboring structures as with “traditional” structural colors, but by its highly efficient scattering around individual nanospheres. Sugimoto explains another advantage: “A single layer of sparsely distributed silicon nanoparticles with a thickness of only 100-200 nanometers shows bright colors but weighs less than half a gram per square meter. This makes our silicon nanospheres one of the lightest color coats in the world.”

The Kobe University team used computational simulations to explore the properties of the ink under different circumstances, such as by varying the size of the particles and the distance between them, and then confirmed their results experimentally. They found that, contrary to intuition, the reflectance was highest when the individual particles were separated instead of when tightly packed. The authors explain, “This high reflectance despite small coverage of the surface by the nanospheres is due to the very large scattering efficiency. The requirement of a very small amount of silicon crystals for coloration is an advantage in the application as a color pigment.”

After further development and refinements, they are expecting interesting applications of their technology. Sugimoto explains, “We can apply it to the coating of, for example, airplanes. The pigments and coatings on an airplane have a weight of several hundreds of kilograms. If we use our nanosphere-based ink, we might be able to reduce the weight to less than 10% of that.”


A single layer of silicon nanospheres produces bright structural colors that are independent of the viewing angle. The color can be controlled by the diameter of the spheres, where smaller particles are bluer and larger ones redder.

A scanning electron micrograph of the nanosphere monolayer shows almost perfectly round particles of uniform size and only small regions of voids or agglomerates.

The nanospheres in a methanol suspension have different colors than when applied to a surface as a monolayer. The Kobe University researchers explain, “This is due to the multiple scattering, i.e., blue light subsides during consecutive scattering by absorption, while red light survives.”

CREDIT

FUJII Minoru

This work was partially supported by JSPS KAKENHI grants 18KK0141, 21H01748, 21H01782 and 22K18949, the JST FOREST Program grant JPMJFR213L and the JST START University Promotion Type grant JPMJST2051 (Kobe University GAP fund).

Kobe University is a national university with roots dating back to the Kobe Commercial School founded in 1902. It is now one of Japan's leading comprehensive research universities with nearly 16,000 students and nearly 1,700 faculty in 10 faculties and schools and 15 graduate schools. Combining the social and natural sciences to cultivate leaders with an interdisciplinary perspective, Kobe University creates knowledge and fosters innovation to address society’s challenges.

Monday, December 18, 2023

WAIT, WHAT?!

Mice with humanized immune systems to test cancer immunotherapies



Peer-Reviewed Publication

KOBE UNIVERSITY

Saito Humanized Mouse Visual Abstract 

IMAGE: 

CURRENTLY DEVELOPED CANCER IMMUNOTHERAPIES MODIFY THE INTERACTION OF CANCER CELLS AND THE IMMUNE SYSTEM, MAKING DRUG TESTING TARGETING HUMAN CANCER OUTSIDE OF CLINICAL TRIALS DIFFICULT. KOBE UNIVERSITY IMMUNO-ONCOLOGIST SAITO YASUYUKI AND HIS TEAM DEVELOPED A MOUSE MODEL WITH A HUMANIZED IMMUNE SYSTEM. WITH THIS THEY SUCCESSFULLY TESTED A NEW THERAPEUTIC APPROACH IN WHICH IMMUNE CELLS THAT PROTECT CANCER CELLS GET ACTIVATED TO ATTACK THEM, BY DISABLING THE IMMUNE CELLS’ RECOGNITION SYSTEM FOR CELLS BELONGING TO THE OWN BODY.

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CREDIT: SAITO YASUYUKI (ILLUSTRATION CREATED WITH BIORENDER.COM)




Mice with human immune cells are a new way of testing anti-cancer drugs targeting the immune system in pre-clinical studies. Using their new model, the Kobe University research team successfully tested a new therapeutic approach that blindfolds immune cells to the body’s self-recognition system and so makes them attack tumor cells.

Cancer cells display structures on their surface that identify them as part of the self and thus prevent them from being ingested by macrophages, a type of immune cell. Cancer immunotherapy aims at disrupting these recognition systems. Previous studies showed that a substance that blinds macrophages to one of these identifiers, called “CD47,” by disabling their CD47-scanning structure, “SIRPα,” can activate the cells to fight the tumor when given in combination with therapeutic cancer-targeting antibodies such as Rituximab. However, because this approach is so specific to the self-identification of human cells, until now it could only be tested in humans or monkeys, making pre-clinical studies in mice impossible.

To overcome this, Kobe University immuno-oncologist SAITO Yasuyuki and his team built on their experience with creating mouse immunological models and transplanted parts of the human immune system into mice. Saito says, "Studies using mouse models with humanized immune systems have focused on lymphocytes, a type of immune cell relevant to infectious diseases.

The special aspect of our approach is that our new mouse model focuses on macrophages because we want to target them for the development of new cancer immunotherapies." This enabled the researchers to both create a more fully functioning mouse model of human cancer and test the effectiveness of the blindfolding approach for the first time in this environment.

Their results, published in the journal Frontiers in Immunology, showed that the macrophage-targeted therapy indeed induced an effective cancer response. However, Saito explains, "The most exciting aspect of this result is that this approach not only promotes the engulfment (ingestion) of tumor cells by macrophages but also reprograms tumor-associated macrophages, one of the current topics of cancer immunotherapy."

The immune system has an ambiguous role in the development of and fight against cancer. On the one hand, it can recognize cancer cells and fight them. On the other hand, macrophages also associate with tumors, both supporting their growth and suppressing other anti-tumor immune responses. To turn these cells against cancer is the novel approach that the Kobe University researchers could now help propel forward with their new humanized mouse model.

But the result has a broader relevance, too. Saito says, "There were no suitable preclinical in vivo models to develop therapeutics targeting human macrophages surrounding tumors, so new approaches had to be tested directly on patients. I believe our model perfectly fills the gap and may help in the selection of the most effective treatment from several candidates for therapeutics targeting human immune cells. The long-term goal of my project is to develop a humanized immune system mouse model that faithfully represents the immune response against the tumor."

The new treatment approach is effective in combating cancer. 14 days after the onset of the treatment, the mice having received the treatment (right) have much smaller tumors (shown through bioluminescence intensities) than those who received only a control (left).

CREDIT

SAITO Yasuyuki

This study was supported by the Ministry of Education, Culture, Sports, Science, and Technology of Japan Grant-in-Aids 20K21547, 21H04807 and 20K16358; by Japan Agency for Medical Research and Development (AMED) grants 21cm0106308h0006 and 22674074; by Japan Science and Technology Agency (JST) grant JPMJPF2018; by the Bristol-Myers Squibb Foundation, the Takeda Science Foundation, and by the Japanese Society of Hematology. It was conducted in collaboration with researchers from the University and University Hospital Zurich and the Comprehensive Cancer Center Zurich.

Kobe University is a national university with roots dating back to the Kobe Commercial School founded in 1902. It is now one of Japan's leading comprehensive research universities with nearly 16,000 students and nearly 1,700 faculty in 10 faculties and schools and 15 graduate schools. Combining the social and natural sciences to cultivate leaders with an interdisciplinary perspective, Kobe University creates knowledge and fosters innovation to address society’s challenges.

 


Not to go on all-fours; that is the Law. Are we not men? Not to suck up Drink; that is the Law. Are we not men? Not to eat Fish or Flesh; that is the Law. Are we not men? Not to claw the Bark of Trees; that is the Law. Are we not men? Not to chase other Men; that is the Law. Are we not men?


ISLAND OF LOST SOULS, BW, 1921

Tuesday, June 07, 2022

The link between temperature, dehydration and tectonic tremors in Alaska

The link between temperature, dehydration and tectonic tremors in Alaska
Figure 1: Tectonic map of the Alaska subduction zone.The thick blue solid line outlines the 
Yakutat terrane. The white circle indicates the epicentre of the low-frequency tectonic
 tremors, and the light blue dashed line shows the area where the tectonic tremors 
occurred, which is used in Figures 2 to 4. The area inside the pink dashed box is the
 model region used in this study, and the pink dashed line down the center of the box
 divides the model region into northeast and southwest areas, and represents the 
boundary between the subducted Yakutat terrane and the subducted Pacific plate in the
 model. The black lines indicate the isodepth contours of the upper surface of the subducted
 oceanic plate (with a contour interval of 20 km), red arrows show the plate motion velocity
 in the Aleutian Trench, and the red triangles indicate volcanoes. Credit: Kobe University

A Kobe University research group has shed light on how low-frequency tectonic tremors occur; these findings will contribute towards better predictions of future megathrust earthquakes.

In addition to the subducting Pacific plate, the Alaska  zone is also characterized by a subducting oceanic plateau called the Yakutat terrane. Low-frequency tectonic tremors, which are a type of slow , have only been detected in the subducted Yakutat terrane area. However, the mechanism by which these events occur is not well understood.

Researchers at Kobe University performed a 3D numerical thermomechanical simulation of thermal convection in the Alaska subduction zone with the aim of revealing the mechanism behind these low-frequency tremors. Based on the 3D thermal structure obtained from the simulation, and the indications of hydrous minerals contained in the slab, the researchers calculated the water content distribution and compared the results of these calculations in the area where the tremors occur.

The results revealed high levels of  in the marine sediment layers and  in the earthquake region. The researchers believe that the reason the tremors only occur in the Yakutat terrane is because the marine sediment layers and ocean crust are thicker there, which means that the level of dehydration is higher than in the western adjacent Pacific plate (where tectonic tremors don't occur).

The link between temperature, dehydration and tectonic tremors in Alaska
Figure 2: Temperature distribution in the slab.The temperature distribution is only plotted in
 the region where the depth of the slab surface is shallower than the bottom of the model
 (200 km), with a contour interval of 100 °C. The white line indicates the area where 
low-frequency tectonic tremors occur, as shown in Figure 1. (a) The slab surface (0 km). 
(b) 6 km depth from the slab surface. (c) 10 km depth from the slab surface.
 Credit: Kobe University

The Kobe University research group consisted of second-year master's student Iwamoto Kaya (Department of Planetology, Graduate School of Science), Academic Researcher Suenaga Nobuaki and Professor Yoshida Shoichi (both of the Research Center for Urban Safety and Security).

These results were published in Scientific Reports.

Main points

Elucidating the mechanism by which low-frequency tremors occur is important for understanding the plate subduction process. It is believed that this will also help illuminate how shallower megathrust earthquakes occur.

In this study, the research group constructed a 3D thermomechanical model of the Alaska subduction zone and calculated the subducting plate's maximum water content and level of dehydration.

The dehydration levels from the subducting plate's marine sediment layers and ocean crust were highest in the region where low-frequency tremors occur. Therefore, it is thought that the water expelled from the subducted plate contributes towards the occurrence of these tectonic tremors.

The link between temperature, dehydration and tectonic tremors in Alaska
Figure 3: The distribution of the slab’s dehydration gradient.The dehydration gradient 
refers to the water content per unit length in the subduction direction of the plate. 
The dehydration gradient distribution is plotted only in the region where the depth of the 
slab surface is shallower than the bottom of the model (200 km) and where the temperature
 is higher than 200 °C (for which phase diagram data exists). The white line indicates the 
area where low- frequency tectonic tremors occur, as shown in Figure 1. (a) The slab 
surface (0 km). (b) 6 km depth from the slab surface. (c) 10 km depth from the slab 
surface. Credit: Kobe University

Research background

An oceanic plateau called the Yakutat terrane is subducting in the Alaska subduction zone. Low-frequency tectonic tremors occur at this subducting plateau. The region where slow earthquakes (such as low-frequency tectonic tremors) occur is deeper and adjacent to the area where megathrust earthquakes occur, which suggests a connection between the two. Revealing the mechanism behind how low-frequency tectonic tremors occur is therefore important for understanding the occurrence of various earthquake events in subduction zones. This research group constructed a 3D thermomechanical model of the Alaska subduction zone so that they could investigate the temperature and level of dehydration in the areas near where low- frequency tremors occur.

Research methodology

The researchers performed a 3D numerical thermomechanical simulation in accordance with the subduction of the Yakutat terrane and Pacific plate in the Alaska subduction zone. It is thought that as the Pacific plate subducts, it brings the hydrous minerals in the slab into the deep high temperature and high pressure regions, and these conditions cause a dehydration reaction where water is expelled from the hydrous minerals.

Based on the 3D thermal structure obtained from the numerical simulation, the researchers determined dehydration levels of the hydrous minerals in the slab. From these results, it was understood that in the region where low- frequency tremors occur, a large amount of water is expelled due to the high temperature and high pressure conditions that cause the dehydration degradation reactions. It is thought that low frequency earthquakes don't occur in the Pacific plate because it has thin layers and therefore experiences little dehydration. On the other hand, the Yakutat terrane's ocean crust and marine sediment layers are comparatively thicker, meaning that it experiences high levels of dehydration. The researchers concluded that this is why low-frequency tectonic tremors only occur in the Yakutat terrane.

The link between temperature, dehydration and tectonic tremors in Alaska
Figure 4: The total sum of the dehydration gradient from the marine sediment layers and 
 ocean crust.The black box indicates the modelled area. The vertical sum of the dehydration
 gradient is only plotted for the region where the depth of the slab surface is shallower than
 the bottom of the model (200 km) and where the temperature is higher than 200 °C 
(for which phase diagram data exists). The white line indicates the area where
 low-frequency tectonic tremors occur, as shown in Figure 1. Credit: Kobe University

Further research

In 1964, a megathrust earthquake occurred in Alaska. This is the biggest earthquake that has occurred in the Alaska subduction zone and the second most powerful earthquake recorded in world history. The low-frequency tectonic tremors that were the subject of this research occur close to the epicenter of the 1964 earthquake, at the downdip of the plate interface.

Next, the research group will continue to make thermomechanical models of various  to search for universal and regional characteristics of the causal mechanisms behind undersea megathrust earthquakes and slow earthquakes. This research will contribute towards improving understanding of how earthquakes occur and our ability to predict future megathrust earthquakes.Weird earthquake reveals hidden mechanism

More information: Kaya Iwamoto et al, Relationship between tectonic tremors and 3-D distributions of thermal structure and dehydration in the Alaska subduction zone, Scientific Reports (2022). DOI: 10.1038/s41598-022-10113-2

Journal information: Scientific Reports 

Provided by Kobe University