Wednesday, January 18, 2023

Oxford’s giants of science announce new collaboration to accelerate pandemic preparedness, structure-based drug discovery and vaccine design

A new Memorandum of Understanding (MoU) to facilitate collaboration and to promote further cooperation between the University of Oxford and Diamond Light Source, the UK’s national synchrotron, was announced today

Business Announcement

DIAMOND LIGHT SOURCE

A new Memorandum of Understanding (MoU) to facilitate collaboration in the field of pandemic preparedness and to promote further cooperation between the University of Oxford and Diamond Light Source, the UK’s national synchrotron, was announced today (12 January).

Oxford and Diamond already have many strong links but now intend to develop their collaborative work to address multiple aspects of anti-viral drug discovery in particular structure-based drug discovery, development of immuno-therapeutics and vaccine design.

Richard Cornall, Nuffield Professor of Clinical Medicine and Head of Department of the Nuffield Department of Medicine (NDM) at the University of Oxford said: “Over the years we have had many research collaborations with Diamond including its Electron Bio-Imaging Centre (eBIC). This has been reinforced by a number of high-level joint appointments and secondments of principal investigators between Diamond and NDM. This agreement recognises that our strengths continue to be highly complementary and that by working together we will have the best chance of developing life-saving ways to prevent and treat our most significant pandemic threats .”

Prof Sir Dave Stuart, Life Sciences Director at Diamond and Joint Head of Structural Biology at University of Oxford adds: “This new agreement will enable us to identify collaborative research opportunities for joint research and development both of mutual or individual interest and to coherently address multiple aspects of therapy development from anti-viral drug discovery to vaccine design.”

Oxford and Diamond intend to develop their collaborative work in the following project areas:

Structure-based drug discovery and development of immuno-therapeutics. Both facilities will look for ways to bring their assets and partnerships to bear on a joint cross disciplinary platform to develop novel class-specific anti-viral drugs and immuno therapeutics. One major shared goal is rapid generation of small molecule and protein hits, refinement to potent leads and in vitro assessment. They may also identify ways to use their shared resources to create a pipeline comprising structure-based drug discovery, in vitro and in vivo assay development, innovative and automated approaches to drug design, advanced enzymology/protein science synthesis and development.

A second shared aim is focused on structural characterisation of the mode of action of neutralising antibodies or nanobodies and the use of such information in the development of new immuno-therapeutic entities.

Vaccine design. The facilities will look to identify ways to bring their assets and partnerships to bear on the generation of high-resolution structural data, and appropriate cellular imaging data, to feed into the design of novel vaccines and the refinement and optimisation of vaccination strategies.

In 2021, Oxford established the Pandemic Sciences Institute, hosted by NDM, as a multi-disciplinary, university-wide initiative to build upon the model of innovation, collaboration and agility that yielded critical breakthroughs for COVID-19, and to identify and counter future pandemic threats.

Diamond, the UK’s national synchrotron, co-founded the COVID Moonshot , a spontaneous global collaboration that started in March 2020, triggered by data from Diamond’s XChem platform for fragment screening, and rapidly identified potent antivirals targeting the main protease of the SARS-CoV-2 virus. These antivirals are now undergoing a preclinical programme funded by the Wellcome Trust; and data openly shared by Moonshot additionally enabled the identification of another promising COVID-19 drug developed by the Japanese pharmaceutical company Shionogi that is now in late-stage clinical trials.

ENDS

For further information: please contact Diamond Communications: Lorna Campbell +44 7836 625999 or Isabelle Boscaro-Clarke +44 1235 778130

Diamond Light Source: www.diamond.ac.uk Twitter: @DiamondLightSou

Notes to Editors

University of Oxford, Nuffield Department of Medicine

The Nuffield Department of Medicine (NDM) at the University of Oxford has a global reach and significant breadth in terms of capabilities and capacity. Its research and innovations have had many positive impacts on human health, including in infectious diseases, cancer, immunology, gastroenterology, respiratory and renal medicine, vaccinology, pathology and general medicine. Over the last fifty years, NDM has pioneered the use of genetics, structural and cellular biology to understand susceptibility to human disease, while maintaining a focus on clinical medicine. NDM has over 1,200 staff in the UK and 2,000 overseas, with over 20 major research institutes, centres and units in Oxford as well as Kenya, Thailand, Vietnam and several other countries. For more information, visit https://www.ndm.ox.ac.uk/

Diamond Light Source: works like a giant microscope, harnessing the power of electrons to produce bright light that scientists can use to study anything from fossils to jet engines to viruses and vaccines. The machine accelerates electrons to near light speeds so that they give off light 10 billion times brighter than the sun. These bright beams are then directed off into laboratories known as ‘beamlines’. Here, scientists use the light to study a vast range of subject matter, from new medicines and treatments for disease to innovative engineering and cutting-edge technology. Whether it’s fragments of ancient paintings or unknown virus structures, at the synchrotron, scientists can study their samples using a machine that is 10,000 times more powerful than a traditional microscope.

(Molecular) view of a key component of the SARS-CoV-2 virus called MPro (Green Grey) with drug site targets identified (yellow)

CREDIT

New research shows pandemic's toll on frontline healthcare workers

Much of the attention on the mental toll suffered by frontline workers has focused on post-traumatic stress disorder (PTSD). New research from a collaboration between Syracuse University and the University of Pittsburgh reveals that even those who are not

Peer-Reviewed Publication

SYRACUSE UNIVERSITY

For frontline healthcare workers, the mental health impact from the pandemic is extending beyond career burnout. Much of the attention on the mental toll suffered by frontline workers has focused on post-traumatic stress disorder (PTSD). New research from a collaboration between Syracuse University and the University of Pittsburgh reveals that even those who are not formally diagnosed as suffering from PTSD still experience critical health symptoms that could lead to other overall health problems.

“While there has been a lot of attention paid to elevated symptom levels indicative of a clinical diagnosis, little attention has been paid to subclinical symptom levels,” said Bryce Hruska, assistant professor of public health at Syracuse University’s Falk College and lead author of the publication reporting this research.

Subclinical (or subthreshold) symptoms refer to psychiatric symptoms – PTSD symptoms in the case of this study – that are not severe enough to be considered indicative of a clinical diagnosis. Hruska and his collaborator Dr. Maria Pacella-LaBarbara at the University of Pittsburgh examined the prevalence and significance of subthreshold PTSD symptom levels (known as PTSS) in frontline healthcare workers responding to the pandemic nearly one year after it started, from December 2020 through February 2021. Data from this study were collected from emergency healthcare workers located primarily in Western Pennsylvania and surrounding areas.

“This is an important study that captures what frontline healthcare workers were experiencing during the pandemic’s second wave and continue to experience as COVID approaches the start of its fourth year in the U.S . It could not have been possible without the work of many people including other researchers and medical personnel who assisted with ensuring that these workers’ experiences were represented,” said Hruska.

“In fact, we found that while 5.5% of the healthcare workers in our sample met criteria for probable PTSD, over half (55.3%) experienced subthreshold symptoms,” said Hruska. So, even though they weren’t reporting symptoms indicative of a clinical diagnosis of PTSD, these workers were still feeling its effects.

Researchers found that workers experiencing these symptoms levels reported:

88% more physical health symptoms (e.g., constant fatigue, weight change, low energy, headache).
36% more sleep problems (e.g., daytime sleepiness, difficulty getting things done) than healthcare workers not experiencing any PTSD symptoms.

“This is a big oversight because these subthreshold symptom levels are common and often confer risk for other health problems,” according to Hruska, who explains that these subthreshold symptoms are often overlooked. That in turn leads to an increase in the risk for subsequently experiencing clinical symptom levels when another significant trauma, such as the current rise in COVID cases, is experienced.

“Thus, while the world tries to move on from the pandemic, our healthcare workers continue to face a significant mental health risk with every surge in cases as is happening now,” said Hruska.

The research was published in January’s edition of the Journal of Psychiatric Research.

JOURNAL

Journal of Psychiatric Research

ARTICLE TITLE

Examining the prevalence and health impairment associated with subthreshold PTSD symptoms (PTSS) among frontline healthcare workers during the COVID-19 pandemic

Survey reveals physical and mental problems among health workers during pandemic

Stress, burnout, pain and poor sleep were some of the most frequent symptoms reported by nursing and other staff who care for patients in a study conducted by researchers at the Federal University of São Carlos in São Paulo state, Brazil
Peer-Reviewed Publication
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO
Poor physical and mental health was frequent among Brazilian health workers employed in the public sector during the COVID-19 pandemic, according to a study by researchers at the Federal University of São Carlos (UFSCar) in São Paulo state, Brazil. The study showed that 86% reported burnout and 81% suffered from stress. They slept badly, experienced depression and complained of aches and pains. On the other hand, most said they were happy to provide meaningful services to society.
The study is still in progress. An analysis of the initial findings is reported in an article published in the journal Healthcare. The initiative as a whole is supported by FAPESP and is now in the final stage of data collection and analysis.
“The paper offers a snapshot of the situation, and we can’t blame the pandemic for all the problems we found, but we believe the particularly heavy effects of COVID-19 in Brazil contributed to these very negative results,” said Tatiana de Oliveira Sato, a professor of physical therapy at UFSCar’s School of Biological and Health Sciences (CCBS).
“Overwork, tough decisions and dramatic experiences all intensified because of the pandemic, affecting all health workers but especially those on the front line,” Sato said. Brazil has had more deaths of healthcare professionals from COVID-19 than any other country, according to the article.
“The original idea for the survey arose just before the pandemic. Even outside the context of the pandemic, health workers have to deal with a heavy schedule and burden of responsibility. We wanted to assess the effects of all this on their physical and mental health. However, when the pandemic arrived, we decided to measure the impact of the public health emergency on the well-being of these workers,” Sato said.
Change of course
The researchers initially planned to interview volunteers on the job. They would all be health workers for the SUS, Brazil’s public health service, in São Carlos. However, the formalities required to prepare for the survey (permits, questionnaires, etc.) became irrelevant between late 2020 and early 2021, when the pandemic was raging across Brazil and vaccine rollout was still incipient.
“Instead, we created an online form and widened the search for respondents throughout the country,” Sato explained. “The criteria for inclusion were working for the SUS, being over 18, and being directly involved in patient care.”
The form was publicized via social media, emails and newspapers. It contained five questionnaires, each designed to quantify an aspect of the respondent’s life. They included the Copenhagen Psychosocial Questionnaire, the Pittsburgh Sleep Quality Index, the Nordic Musculoskeletal Questionnaire, and the Beck Depression Inventory.
The form was 10 pages long. “We reckoned it took 20-30 minutes to answer all the questions. The questionnaires were only included in the analysis if they were completely filled out,” Sato said. Local respondents also used equipment to measure the amount of physical activity for inclusion in the survey.
Eventually, 125 health workers took part in the study. The first stage of data collection lasted from June 2021 to April 2022. The data published so far constitutes a baseline and does not yet cover physical activity, but the project calls for four more steps to take place three, six, nine and 12 months after the first collection.
“We called this cohort HEROES. We thought a lot about the name because we didn’t want it to be taken as implying that health workers are superhuman and never get tired or dejected. The name is intended as a homage. We also wanted to call attention to the need to valorize health workers, who were disproportionately affected by the pandemic,” Sato said. Some 60 respondents participated in all stages.
Initial findings
The data presented in the article show a high prevalence of musculoskeletal symptoms: 64% reported neck pain, 62% shoulder pain, 58% upper back pain and 61% lower back pain.
For Sato, all this was certainly due largely to long hours, being on their feet most of the time, lifting patients and working flat out. “But mental stress can also trigger these kinds of pain because of the tension it creates in the body,” she noted.
The frequency of psychosocial problems is striking, according to the authors, with stress affecting 81% of the participants and 86% suffering burnout. Symptoms of mild depression were detected in 22%, moderate depression in 16% and severe depression in 8%. In addition, 74.4% said they slept badly.
It is still necessary to analyze the evolution of the indicators over time, however. According to Sato, prevalence levels tend to be lower in studies of other populations. For example, five meta-analyses mentioned in the article found burnout rates ranging from 25% to 37%, while nine such studies found that between 17% and 57% of the respective samples suffered from stress. These proportions are far lower than those reported in the study by the researchers at UFSCar.
Workplace climate
Other psychosocial factors were assessed via the Copenhagen questionnaire, with a large majority of respondents giving negative scores to the emotional demands of their work (75%), its pace and intensity (61%), and its unpredictability (47%). These were the psychosocial factors with the worst ratings in the survey.
The proportions who reported offensive behavior were also strikingly high: 15% said they had been the object of unwanted sexual attention or harassment, while 26% had been threatened, 17% bullied, and 9% physically assaulted.
“This is deplorable. All these numbers should be zero. Occurrences of this kind in any workplace are unacceptable,” Sato said. Sexual harassment was reported most by younger women, she noted. Threats of violence came mainly from patients and their relatives, while fellow workers were more often bullies than supervisors.
On the positive side, more than 90% said they believed their work was very meaningful and some 80% said they were committed to their work despite the stress.
Limitations and implications
For Sato, the relatively small number of respondents to the first form (125) and the even smaller number (about 60) remaining in the last stage of the survey were a limitation because they prevented extrapolation and analysis of data for other regions. “Nevertheless, the survey was valuable because of its depth,” she said.
The information obtained, she added, is sufficient to lobby top management of the SUS and the authorities for improvements to working conditions. Physically and mentally distressed professionals cannot always provide the best patient care.
“This has to lead to increased staffing, better pay, less exhausting hours and proper training,” Sato said. Simple matters such as providing training for staff on the best ways to lift and carry patients without injuring themselves could lead to significant improvements in musculoskeletal terms. Similarly, creation of support networks would help nursing and other staff cope with the emotional impact. “Health workers need a lot of support. They’re people, too,” she said.
About São Paulo Research Foundation (FAPESP)
The São Paulo Research Foundation (FAPESP) is a public institution with the mission of supporting scientific research in all fields of knowledge by awarding scholarships, fellowships and grants to investigators linked with higher education and research institutions in the State of São Paulo, Brazil. FAPESP is aware that the very best research can only be done by working with the best researchers internationally. Therefore, it has established partnerships with funding agencies, higher education, private companies, and research organizations in other countries known for the quality of their research and has been encouraging scientists funded by its grants to further develop their international collaboration. You can learn more about FAPESP at www.fapesp.br/en and visit FAPESP news agency at www.agencia.fapesp.br/en to keep updated with the latest scientific breakthroughs FAPESP helps achieve through its many programs, awards and research centers. You may also subscribe to FAPESP news agency at http://agencia.fapesp.br/subscribe

JOURNAL

Healthcare

DOI

10.3390/healthcare10102096

SUBJECT OF RESEARCH

People

ARTICLE TITLE

Poor Health Conditions among Brazilian Healthcare Workers: The Study Design and Baseline Characteristics of the HEROES Cohort

Family dynamics and doctors' emotions drive useless end-of-life care

Peer-Reviewed Publication

RUTGERS UNIVERSITY

Researchers from Rutgers and other universities have developed a behavioral model that explains a long-standing healthcare mystery: Why do so many terminally ill patients undergo intense last-ditch treatments with little chance of meaningful life extension?

Surveys repeatedly indicate that nearly all people would rather die peacefully at home, yet painful, long-shot treatments remain common, and efforts to reduce usage have failed.

Previous analyses have mostly emphasized patients’ treatment preferences at the end of life. The new model, which its creators named the Transtheoretical Model of Irrational Biomedical Exuberance (TRIBE), focuses squarely on clinician psychology and family dynamics.

“Old models tended to assume that clinicians were purely rational agents, leading patients toward logical choices,” said Paul R. Duberstein, lead author of the study and chair of the Department of Health Behavior, Society and Policy at the Rutgers School of Public Health. “Once doctors have recommended a treatment or procedure, there’s enormous pressure on patients to undergo it.”

The TRIBE model combines two older theories – Socioemotional Selectivity Theory and Terror Management Theory – to explain why this happens. The model shows how emotional pressures on doctors and complex family dynamics provoke excessive efforts to cure incurable conditions.

“This model incorporates research showing that clinicians are emotional beings, like all people, and these emotions strongly impact their patients’ choices,” Duberstein said. “Doctors hate to ‘give up’ on patients, so they often recommend treatments with very little chance of success. That won’t change until we improve medical education and the culture of irrational biomedical exuberance.”

“Irrational exuberance” is a term that economist Alan Greenspan famously used to describe investor sentiment in the lead-up to the dot-com crash, but Duberstein and his colleagues said it has long affected doctors and patients as much as it has affected Wall Street. They read of one-in-a-million cures and irrationally believe that they or their patients will be that one in a million – just as people who purchase lottery tickets think they’ll be the lucky winners.

Pointing out the irrationality of the choice doesn’t affect doctors any more than it affects lottery players. Indeed, the researchers believe, it affects doctors less because, unlike gambling, which is often portrayed as a vice, the struggle to preserve life is typically portrayed as a virtue. Motives to prescribe long-shot treatments are noble – to avoid death, save a life, “do all we can,” “fight a battle” and “never give up.” In this view, failing to prescribe long-shot treatments is tantamount to abandoning patients and, for patients, failing to try these treatments is tantamount to abandoning loved ones.

The authors, who also hail from Tulane, Rochester and Rowan, call for new approaches to clinical care and public education that will address the emotions that fuel useless treatments at the end of life. “At some level, every patient death is a potential source of shame for doctors and a source of guilt for surviving family members,” Duberstein said. “By changing the culture of medical education and broader cultural attitudes toward death, we can address the emotions and family dynamics that have prevented too many patients from receiving quality care in their final days and weeks of life.”

JOURNAL

Social Science & Medicine

DOI

10.1016/j.socscimed.2022.115546

METHOD OF RESEARCH

Survey

SUBJECT OF RESEARCH

Not applicable

ARTICLE TITLE

The TRIBE model: How socioemotional processes fuel end-of-life treatment in the United States

New roundtable on health equity in communities of color

Peer-Reviewed Publication

MARY ANN LIEBERT, INC./GENETIC ENGINEERING NEWS

A new Roundtable focusing on health equity in communities of color features the expertise and insights of five distinguished academic and social justice leaders. Moderated by Gail Christopher, DN, Executive Director of the National Collaborative for Health Equity (NCHE), the Roundtable was published today on the National Day of Racial Healing in the peer-reviewed journal Health Equity. Click here to read the roundtable now.

"At this unique moment in our nation's history, we have collectively endured the most devastating health crisis in our history, the COVID-19 pandemic," says Christopher. "Its harmful effects have been disproportionately experienced by communities of color. Within every crisis, there is an opportunity for healing and growth. The National Collaborative for Health Equity is pleased to offer this roundtable and the accompanying articles as a contribution to our healing journey."

Participants in the Roundtable represent the inaugural group of NCHE Senior Scholars. They include Charmaine Royal, PhD, MS, Robert O. Keohane Professor of African & African American Studies, Biology, Global Health, and Family Medicine & Community Health at Duke University; Lisa Sockabasin, MS, a Citizen of the Passamaquoddy Tribe at Motahkomikum and co-CEO of Wabanaki Public Health and Wellness; Mindy Thompson Fullilove, MD, LFAPA, a Social Psychiatrist and Professor of Urban Policy and Health at The New School; Alan Jenkins, JD, MA, Professor of Practice at Harvard Law School; and Algernon Austin, PhD, Director for Race and Economic Justice at the Center for Economic and Policy Research

Also included in the issue of Health Equity to be published on January 20, 2023, are comprehensive articles by each of the Roundtable participants that align with the pillars of the Truth, Racial Healing & Transformation™ (TRHT™) Framework, a national and community-based effort established by the W.K. Kellogg Foundation to engage communities, organizations, and individuals from multiple sectors across the United States in racial healing and addressing present-day inequities linked to historic and contemporary beliefs in a hierarchy of human value.

About the Journal
Health Equity is the Official Journal of the National Collaborative for Health Equity. The peer-reviewed open-access journal meets the urgent need for authoritative information about health disparities and health equity among vulnerable populations. With coverage ranging from translational research to prevention, diagnosis, treatment, and management of disease and illness, the Journal serves as a primary resource for organizations and individuals who serve these populations at the community, state, regional, tribal, and national levels.

About the National Collaborative
Officially launched in 2014, National Collaborative for Health Equity builds on 18-years of comprehensive efforts to advance health equity. The National Collaborative was established to promote health and racial equity through action, leadership, and collaboration. Health equity, in our view, requires creating the conditions that foster the best possible health for all populations, regardless of race, ethnicity, socioeconomic status, or nativity.

About the Publisher
Mary Ann Liebert, Inc., publishers is known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research. A complete list of the firm's 90 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.

JOURNAL

Health Equity

DOI

10.1089/heq.2022.29019.rtd

METHOD OF RESEARCH

Commentary/editorial

SUBJECT OF RESEARCH

People

ARTICLE TITLE

Addressing Racism and Its Deeply Entrenched Dynamics: A 21st Century Imperative

New research furthers case for exercise promoting youthfulness

Evidence shows that exercise promotes a molecular profile in muscle that is consistent with expression of youthfulness-promoting Yamanaka factors

Peer-Reviewed Publication

UNIVERSITY OF ARKANSAS

Kevin Murach — IMAGE: KEVIN MURACH view more
CREDIT: UNIVERSITY RELATIONS

A recent paper published in the Journal of Physiology deepened the case for the youthfulness-promoting effects of exercise on aging organisms, building on previous work done with lab mice nearing the end of their natural lifespan that had access to a weighted exercise wheel.

The densely detailed paper, “A molecular signature defining exercise adaptation with ageing and in vivo partial reprogramming in skeletal muscle,” lists a whopping 16 co-authors, six of whom are affiliated with the U of A. The corresponding author is Kevin Murach, an assistant professor in the U of A’s Department of Health, Human Performance and Recreation, and the first author is Ronald G. Jones III, a Ph.D. student in Murach’s Molecular Muscle Mass Regulation Laboratory.

For this paper, the researchers compared aging mice that had access to a weighted exercise wheel with mice that had undergone epigenetic reprogramming via the expression of Yamanaka factors.

The Yamanaka factors are four protein transcription factors (identified as Oct3/4, Sox2, Klf4 and c-Myc, often abbreviated to OKSM) that can revert highly specified cells (such as a skin cell) back to a stem cell, which is a younger and more adaptable state. The Nobel Prize in Physiology or Medicine was awarded to Dr. Shinya Yamanaka for this discovery in 2012. In the correct dosages, inducing the Yamanaka factors throughout the body in rodents can ameliorate the hallmarks of aging by mimicking the adaptability that is common to more youthful cells.

Of the four factors, Myc is induced by exercising skeletal muscle. Myc may serve as a naturally induced reprogramming stimulus in muscle, making it a useful point of comparison between cells that have been reprogrammed via over expression of the Yamanaka factors and cells that have been reprogrammed through exercise — “reprogramming” in the latter case reflecting how an environmental stimulus can alter the accessibility and expression of genes.

The researchers compared the skeletal muscle of mice who had been allowed to exercise late in life to the skeletal muscle of mice that overexpressed OKSM in their muscles, as well as to genetically modified mice limited to the overexpression of just Myc in their muscles.

Ultimately, the team determined that exercise promotes a molecular profile consistent with epigenetic partial programming. That is to say: exercise can mimic aspects of the molecular profile of muscles that have been exposed to Yamanaka factors (thus displaying molecular characteristics of more youthful cells). This beneficial effect of exercise may in part be attributed to the specific actions of Myc in muscle.

While it would be easy to hypothesize that someday we might be able to manipulate Myc in muscle to achieve the effects of exercise, thus sparing us the actual hard work, Murach cautions that would be the wrong conclusion to draw.

First, Myc would never be able to replicate all the downstream effects exercise has throughout the body. It is also the cause of tumors and cancers, so there are inherent dangers to manipulating its expression. Instead, Murach thinks manipulating Myc might best be employed as an experimental strategy to understand how to restore exercise adaptation to old muscles showing declining responsiveness. Possibly it could also be a means of supercharging the exercise response of astronauts in zero gravity or people confined to bed rest who only have a limited capacity for exercise. Myc has many effects, both good and bad, so defining the beneficial ones could lead to a safe therapeutic that could be effective for humans down the road.

Murach sees their research as further validation of exercise as a polypill. “Exercise is the most powerful drug we have,” he says, and should be considered a health-enhancing — and potentially life-extending — treatment along with medications and a healthy diet.

Murach and Jones’ co-authors at the U of A included exercise science professor Nicholas Greene, as well as contributing researchers Francielly Morena Da Silva, Seongkyun Lim and Sabin Khadgi.

JOURNAL

The Journal of Physiology

DOI

10.1113/JP283836

METHOD OF RESEARCH

Experimental study

SUBJECT OF RESEARCH

Animals

ARTICLE TITLE

A molecular signature defining exercise adaptation with ageing and in vivo partial reprogramming in skeletal muscle

Body Dissatisfaction Can Lead to Eating Disorders at Any Age

New study suggests that perimenopause may be an especially risky time for women who are trying to overcome a poor body image

Peer-Reviewed Publication

THE NORTH AMERICAN MENOPAUSE SOCIETY (NAMS)

CLEVELAND, Ohio (Jan 18, 2023)—Eating disorders are stereotypically associated with adolescents and young adults. Growing evidence, however, suggests that these conditions can occur at any time during a woman’s lifespan, including at midlife. A new study finds that body dissatisfaction is a primary cause of eating disorders, especially during perimenopause. Study results are published online today in Menopause, the journal of The North American Menopause Society (NAMS).

Eating disorders are serious mental health conditions characterized by disturbances in eating behavior and body image that occur in approximately 13.1% of women across the lifespan. The prevalence of any eating disorder specifically for women aged older than 40 years is roughly 3.5%, with specific symptoms such as dissatisfaction with eating patterns being documented as high as 29.3%.

Serious complications such as high mortality and morbidity are associated with eating disorders. These adverse health events are likely to be magnified when present at older ages. However, few studies on eating disorders have included participants at midlife, including premenopause, perimenopause, and postmenopause.

There is some evidence that supports the idea that perimenopausal women have the highest rates of dysregulated eating behaviors (eg, weight-control behaviors such as regular counting of calories or consumption of diet foods) of any reproductive stage at midlife and are significantly different from premenopausal women with regard to body dissatisfaction and feelings of fatness. Although findings such as these remain scant; the association between eating disorders and symptoms of perimenopause (eg, negative mood, depression, and fatigue) confirm that perimenopause may be a particularly risky time for eating pathology.

In this new small study, which sought to investigate the structure of eating disorder symptoms specifically during perimenopause and early postmenopause, the researchers used network analysis statistical models to compare the structure and importance of specific eating disorder symptoms across reproductive stages. Although they admit that larger studies are necessary with this underrepresented female population, the researchers believe that the study confirms that dissatisfaction with body image is a key risk factor for eating disorders across the lifespan, especially at midlife.

Study results are published in the article “Network analysis of eating disorder symptoms in women in perimenopause and early postmenopause.”

“This study shows that, similar to studies in young adults, dissatisfaction with body image remains a core feature of eating disorder pathology in midlife women. Specifically, fear of gaining weight and fear of losing control over eating habits are central symptoms of eating disorders in perimenopause and early postmenopause. These findings may help direct more targeted treatment strategies in women during midlife,” says Dr. Stephanie Faubion, NAMS medical director.

For more information about menopause and healthy aging, visit www.menopause.org. Founded in 1989, The North American Menopause Society (NAMS) is North America’s leading nonprofit organization dedicated to promoting the health and quality of life of all women during midlife and beyond through an understanding of menopause and healthy aging. Its multidisciplinary membership of 2,000 leaders in the field—including clinical and basic science experts from medicine, nursing, sociology, psychology, nutrition, anthropology, epidemiology, pharmacy, and education—makes NAMS uniquely qualified to serve as the definitive resource for health professionals and the public for accurate, unbiased information about menopause and healthy aging. To learn more about NAMS, visit www.menopause.org.

JOURNAL

Menopause

DOI

10.1097/GME.0000000000002141

METHOD OF RESEARCH

Data/statistical analysis

SUBJECT OF RESEARCH

People

ARTICLE TITLE

Network analysis of eating disorder symptoms in women in perimenopause and early postmenopause

ARTICLE PUBLICATION DATE

18-Jan-2023

New study showed how people interacted with chatbots during COVID-19 pandemic

Conversation with AI chatbot was found to reduce negative moods during COVID-19 lockdowns

Peer-Reviewed Publication

INSTITUTE FOR BASIC SCIENCE

IMAGE: TOPICS DISCUSSED BY USERS WITH THE CHATBOT IDENTIFIED BY THE LATENT DIRICHLET ALLOCATION TOPIC MODEL AND THEIR PREVALENCE. view more
CREDIT: INSTITUTE FOR BASIC SCIENCE

The COVID-19 pandemic has increased people's reliance on digital platforms, such as social media, to obtain information and communicate their thoughts and emotions with their peers. The sudden shift from offline to online interactions due to the COVID-19 pandemic has fueled the popularity of chatbots in many fields, including the medical domain. The World Health Organization (WHO) has even used a chatbot to fight against false information, and they are still looking into how this new technology can help them prepare for future pandemics.

A new study has shown the potential of AI chatbots to relieve users' anxiety and quickly deliver information during major social upheavals. Led by Chief Investigator CHA Meeyoung of the Data Science Group within the Institute for Basic Science (IBS) and Dr. CHA Chiyoung from Ewha Woman's University's College of Nursing, the researchers analyzed nearly 20,000 conversations between online users and a chatbot called SimSimi. This commercial chatbot has served over 400 million users worldwide in 81 languages. The joint research team investigated how users from the United States, United Kingdom, Canada, Malaysia, and the Philippines used the chatbot during the COVID-19 pandemic.

This study is one of the first to analyze large-scale data on conversations related to COVID-19 between chatbots and humans.

Dr. CHIN Hyojin, the lead author of the study said, “Chatbots are a promising tool to fulfill people's informational needs in challenging times. While health institutions such as the Korea Center for Disease Control and Prevention and the World Health Organization (WHO) have used chatbots to provide the most up-to-date information on the spread and symptoms of COVID-19 to billions of people, it was unclear how users interacted with such systems in times of crisis.”

The researchers employed natural language processing (NLP) techniques to identify a series of topics discussed by online users when talking to the chatbot. The results show that users use the chatbot to ask questions about the disease and have a small talk during periods of social isolation due to the pandemic.

During the pandemic's lockdowns, the chatbot frequently served as a conversation companion for obtaining information and expressing emotions. The researchers found 18 COVID-19-related topics that people conversed with the chatbot using topic modeling, a machine learning technique that discovers conversation topics from large-scale text data, and classified them into overarching themes.

Some of these themes included the outbreak of COVID-19, preventative behaviors, the physical and psychological impact of COVID-19, people and life in the pandemic, and questions about COVID-19. This showed that many users sought information and queried the chatbot about the pandemic, even though the particular chatbot under study was not designed to deliver specific information on COVID-19.

In terms of how people felt, the team employed computational tools to compare how each of these themes made them feel. Although some topics, such as masks, lockdowns, and disease dread elicited negative emotions, it was discovered that daily chatter with the chatbot mostly led to positive emotions. There were also regional differences based on geographics. For example, U.S.-based users were found to more frequently use negative keywords in comparison to users from Asia.

Chief Investigator Cha said, “This study is unique because it is the first to use commercial chatbot conversations that are not dedicated to mental support during the pandemic. Because individuals are sharing their concerns and seeking assistance from social chatbots, they can be an essential tool for healthcare during crises like the COVID-19 pandemic. The next stage is understanding individuals' intentions and utilizing the knowledge to create systems that better respond to user demands during difficult times.”

The study was published in the Journal of Medical Internet Research (JMIR) as part of a series called "Chatbots and COVID-19," which was organized by the WHO.

The average percentage of positive and negative-related words in COVID-19–related conversations by country according to the Linguistic Inquiry and Word Count dictionary.

During the Covid-19 pandemic, users sought health-related information and shared emotional messages with the chatbot, indicating the potential use of chatbots to provide accurate health information and emotional support.

CREDIT

Institute for Basic Science

JOURNAL

Journal of Medical Internet Research

DOI

10.2196/40922

METHOD OF RESEARCH

Data/statistical analysis

SUBJECT OF RESEARCH

People

ARTICLE TITLE

User-Chatbot Conversations During the COVID-19 Pandemic: Study Based on Topic Modeling and Sentiment Analysis