Sunday, July 05, 2020

Showing pro-diversity feelings are the norm makes individuals more tolerant

UNIVERSITY OF WISCONSIN-MADISON
Drawing on strategies that have worked in anti-smoking, safe-sex and energy-saving campaigns, University of Wisconsin-Madison researchers decided to try to change behavior by showing people that positive feelings about diversity are the norm.
"In any other domain of public health -- saving for retirement, sustainability, eating healthy -- it's the key thing to communicate: It's the right thing to do, your peers do it, and your peers would actually approve of you doing it as well," says Markus Brauer, the UW-Madison psychology professor whose lab designed the pro-diversity intervention.
It's an effect that's reflected in attitudes about ongoing protests over Black people killed by police officers. Exposed to larger crowds, more frequent news coverage and the opinions of friends and neighbors, more people have expressed support for Black Lives Matter groups and activities.
"People are heavily influenced by finding out what their peers have done," Brauer says. "But in the diversity domain, we haven't been trying this."
The researchers, who published their findings today in the journal Nature Human Behaviour, conducted extensive focus groups with UW-Madison students.
"We asked them -- students of color and white students, students of the LGBT+ community: What actually is it that decreases your sense of belonging? What are the kinds of behaviors that hurt your feelings, that make you feel excluded?" Brauer says. "And then please tell us, what are the behaviors that would make you feel welcome?"
The non-white students felt like they were kept at a distance from white students -- not included in class groups or projects, not included in activities, not invited to participate in simple interactions.
"When we asked about what decreased their sense of belonging, they didn't complain so much about racial slurs or explicit forms of discrimination," says Brauer. "It was the distance, the lack of interest, the lack of caring that affected them."
Brauer, graduate student Mitchell Campbell, and Sohad Murrar, a former graduate student of Brauer's who is now a psychology professor at Governors State University in Illinois, used what they learned to choose their messages.
"We used a social marketing approach, where we identify a target audience, we decide what our target behavior is, and then we show people how their peers support that behavior," Brauer says.
They designed a relatively simple poster, covered in students' faces and reporting actual survey results -- that 93 percent of students say they "embrace diversity and welcome people from all backgrounds into our UW-Madison community," and that 84 percent of them agreed to be pictured on the poster. They also produced a five-minute video, which described the pro-diversity opinions reported by large majorities in other campus surveys and showed real students answering questions about tolerance and inclusion.
In a series of experiments over several years, hundreds of students were exposed passively to the posters in brief encounters in study waiting rooms or hung day after day on the walls of their classrooms. In other experiments, the video was shown to an entire class during their first meeting. Control groups came and went from waiting rooms and classroom with no posters, or watched videos about cranberry production, or other alternatives to the study materials.
Then the researchers surveyed subjects to assess their attitudes about appreciation for diversity, attitudes toward people of color, intergroup anxiety, their peers' behaviors and other measures.
"When we measured 10 or 12 weeks later, the students who were exposed to the interventions report more positive attitudes towards members of other groups and stronger endorsement of diversity," Brauer says.
The differences for students from marginalized groups went further.
"The students belonging to marginalized groups tell us that they have an enhanced sense of belonging. They are less anxious in interactions with students from other ethnic groups. They tell us that they're less and less the target of discrimination," Brauer says. "They evaluate the classroom climate more positively, and feel that they are treated more respectfully by their classmates."
The researchers tested the effectiveness of their diversity intervention in a series of UW-Madison courses in which white students have historically received better grades than their non-white peers. In course sections that viewed the 5-minute video during their first meeting -- classes including more than 300 students -- the privileged and marginalized students' grades were equal in the end.
"We know the marginalized students experience discrimination; we know their feelings are valid. But we know, too, from the campus climate surveys and our own extensive surveys, that their fellow students report real appreciation for diversity, and tell us that they want to be inclusive," Brauer says. "They stay socially distant, though, because they worry about putting themselves out there. Our experience is that this intervention is changing those perceptions and experiences, and possibly the behavior, of both groups."
It may be the first result of its kind for such a long-running study with so many participants, and the researchers are hopeful that future work will help better reveal whether students actually change the way they treat each other.
"Promoting inclusion and dismantling systemic racism is one of the most important issues of our times. And yet, it turns out that many pro-diversity initiatives are not being evaluated," says Brauer, whose work was supported in part by funding from the office of UW-Madison's vice provost and chief diversity officer. "We really need evidence-based practices, but for a long time we've had no idea whether the things we do in the diversity domain actually have a beneficial effect. We're hoping to change that."
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--Chris Barncard, barncard@wisc.edu
DOWNLOAD IMAGE AND VIDEO LINK: https://uwmadison.box.com/v/diversity-feelings

Different tracks, same dinosaurs: Brown researchers dig deeper into dinosaur movements

BROWN UNIVERSITY

PROVIDENCE, R.I. [Brown University] -- When picturing dinosaur tracks, most people imagine a perfectly preserved mold of a foot on firm layer of earth. But what if that dinosaur was running through mud, sinking several inches -- or even up to their ankles -- into the ground as it moved?
Using sophisticated X-ray-based technology, a team of Brown University researchers tracked the movements of guineafowl to investigate how their feet move below ground through various substrates and what those findings could mean for understanding fossil records left behind by dinosaurs.
They found that regardless of the variability in substrates, or the guineafowl moving at different speeds, sinking at different depths or engaging in different behaviors, the birds' overall foot movement remained the same: The toes spread as they stepped onto the substrate surface, remained spread as the foot sank, collapsed and drew back as they were lifted from the substrate, and exited the substrate in front of the point of entry, creating a looping pattern as they walked.
And part of what that means is that fossilized dinosaur tracks that look distinct from each other, and appear to be from different species, might instead come from the same dinosaurs.
"This is the first study that's really shown how the bird foot is moving below ground, showing the patterns of this subsurface foot motion and allowing us to break down the patterns that we're seeing in a living animal that has feet similar to those of a dinosaur," said Morgan Turner, a Ph.D. candidate at Brown in ecology and evolutionary biology and lead author of the research. "Below ground, or even above ground, they're responding to these soft substrates in a very similar way, which has potentially important implications for our ability to study the movement of these animals that we can't observe directly anymore."
The findings were published on Wednesday, July 1, in the Royal Society journal Biology Letters.
To make the observations, Turner and her colleagues, Professor of Biology and Medical Science Stephen Gatesy and Peter Falkingham, now at Liverpool John Moores University, used a 3D-imaging technology developed at Brown called X-ray Reconstruction of Moving Morphology (XROMM). The technology combines CT scans of a skeleton with high-speed X-ray video, aided by tiny implanted metal markers, to create visualizations of how bones and muscles move inside humans and animals. In the study, the team used XROMM to watch guineafowl move through substrates of different hydration and compactness, analyzing how their feet moved underground and the tracks left behind.
Sand, typically a dense combination of quartz and silica, does not lend itself well to X-ray imaging, so the team used poppy seeds to emulate sand. Muds were made using small glass bubbles, adding various amount of clay and water across 107 trials to achieve different consistencies and realistic tracks.
They added metal markers underneath the claws of the guineafowl to allow for tracking in 3D space. It's these claw tips that the researchers think are least disturbed by mud flow and other variables that can impact and distort the form of the track.
Despite the variation, the researchers observed a consistent looping pattern.
"The loops by themselves I don't think are that interesting," Gatesy said. "People are like, 'That's nice. Birds do this underground. So what?' It was only when [Turner] went back into it and said, 'What if we slice those motion trails at different depths as if they were footprints?' Then we made the nice connection to the fossils."
By "slicing" through the 3D images of the movement patterns at different depths, the researchers found similarities between the guineafowl tracks and fossilized dinosaur tracks.
"We don't know what these dinosaurs were doing, we don't know what they were walking through exactly, we don't know how big they were or how deep they were sinking, but we can make this really strong connection between how they were moving and some level of context for where this track is being sampled from within that movement," Turner said.
By recognizing the movement patterns, as well as the entry and exit point of the foot through various substrates, the team says they're able to gain a better understanding of what a dinosaur track could look like.
"You end up generating this big diversity of track shapes from a very simple foot shape because you're sampling at different depths and it's moving in complicated ways," Gatesy said. "Do we really have 40 different kinds of creatures, each with a differently shaped foot, or are we looking at some more complicated interaction that leaves behind these remnants that are partly anatomical and partly motion and partly depth?"
To further their research, the team spent time at the Beneski Museum of Natural History at Amherst College in Massachusetts, which is home to an expansive collection of penetrative tracks discovered in the 1800s by geologist Edward Hitchcock.
Hitchcock originally believed that his collection housed fossil tracks from over 100 distinct animals. Because of the team's work with XROMM, Gatesy now thinks it's possible that at least half of those tracks are actually from the same dinosaurs, just moving their feet in slightly different ways or sampled at slightly different depths.
"Going to museum together and being able to pick out these features and say, 'We think this track is low in the loop and we think this one is high,' that was the biggest moment of insight for me," Turner said.
Turner says she hopes their research can lead to a greater interest in penetrative tracks, even if they seem a little less pretty or polished than the tracks people are used to seeing in museums.
"They have so much information in them," Turner said, "and I hope that this gives people a lens, a new way to view these footprints and appreciate the movement preserved within in them."
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This work was supported by the US National Science Foundation (EAR 1452119 to SMG and PLF; IOS 0925077 to SMG), a Marie Curie International Outgoing Fellowship within the 7th European Framework Programme to PLF, and the Bushnell Research and Education Fund to MLT.

Alarming long-term effects of insecticides weaken ant colonies

UNIVERSITY OF BERN
IMAGE
IMAGE: YOUNG COLONY OF THE BLACK GARDEN ANT (LASIUS NIGER) WITH QUEEN, WORKERS AND BROOD (EGGS, LARVAE AND PUPAE) IN A NESTING TUBE. view more 
CREDIT: © DANIEL SCHLAEPPI
"Ants are one of the most important animal groups on our planet. However, they are also affected by the recently observed global declines in abundance and diversity of insects", says Daniel Schläppi of the Institute of Bee Health of the University of Bern, main author of the study. Evidence suggests that pesticides are among the factors responsible for the observed declines. "One problem of these substances is their persistence and the potential to contaminate soils and water, even in areas in which they are not applied", says co-author Gaétan Glauser from the University of Neuchâtel.
But so far, no data existed to show how exposure to low concentrations, which do not induce direct mortality, affect ants in the long run. The data, collected at the University of Bern in cooperation with Agroscope and the University of Neuchâtel, clearly demonstrate previously overlooked long-term effects, which are not detectable during the first year of colony development. The results are published in "Communications Biology", an Open-Access Journal of Nature. According to the authors, this study highlights the importance to develop sustainable agricultural practices that incorporate reduced use of agro-chemicals to prevent irreparable damages to natural ecosystems.
Worrying long-term impacts
Thiamethoxam has a clear negative impact on the health of ants. Thiamethoxam is a neonicotinoid insecticide used to combat pest insects that threaten our harvest. Unfortunately, there is more and more evidence showing that thiamethoxam and similar agro-chemicals have negative consequences for other beneficial insects, including ants and honey bees.
"With our study we show that ants, which play a very important roles in our ecosystems and provide valuable ecosystem services such as natural pest control, are negatively affected by neonicotinoids too", says Schläppi.
In the present work, colonies of black garden ants were chronically exposed to field realistic concentrations of thiamethoxam over 64 weeks. Colonies were raised in the laboratory from queens that were captured in the field. Before the first overwintering of the colonies no effect of neonicotinoid exposure on colony strength was visible. However, until the second overwintering it became apparent that colonies exposed to thiamethoxam were significantly smaller than control colonies. Because the number of workers is a very important factor for the success of an ant colony, the observed effects are most likely to compromise colony survivorship. Considering the important role of ants in natural ecosystems, our results indicate that neonicotinoids impose a threat to ecosystem functioning.
The call for sustainable solutions
"Accumulating long-term impact of neonicotinoids on ants is alarming", says Prof. Peter Neumann of the Institute of Bee Health at the University of Bern. "This is an exemplary study showing how negative effects of an environmental contaminant only become visible after long monitoring, but with potentially far reaching consequences". Therefore, the authors stress the importance to include ants as model organisms and to fully incorporate long-term effects in future risk assessment schemes for more sustainable agriculture.
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This study was financially supported by the Béatrice Ederer-Weber Foundation, the Vinetum Foundation and the Swiss Federal Office for the Environment (FOEN). The research was conducted by scientist working at the University of Bern (Institute of Bee Health, Vetsuisse Faculty), Agroscope (Swiss Bee Research Centre) as well as University of Neuchâtel (Neuchâtel Platform of Analytical Chemistry).

Algae as living biocatalysts for a green industry

RUHR-UNIVERSITY BOCHUM
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IMAGE: ALGAE HOLD GREAT POTENTIAL FOR ENVIRONMENTALLY FRIENDLY ENERGY PRODUCTION. view more 
CREDIT: RUB, MARQUARD
Better still: living algae can be used as biocatalysts for certain substances, and they bring the co-substrate along, producing it in an environmentally friendly manner through photosynthesis. The team published its report in Algal Research on 17. June 2020.
It's a question of 3D structure
Many chemical substances in cosmetics, food or medicines can assume slightly different three-dimensional structures, with only one of them generating the desired fragrance or medical effect. The chemical production of the right substances is often not environmentally friendly, as it requires high temperatures or special solvents. In nature, however, certain proteins do exist that produce the required product at mild temperatures and in water. In the process, they often generate exactly the 3D structure of the substance that is needed by the industry.
These so-called old yellow enzymes, OYEs for short, owe their name to their naturally yellow colour. They occur in bacteria, fungi and plants, are in part well studied and offer considerable potential for a bio-based economy. However, they have one disadvantage: in order to carry out their reaction, they need the co-substrate NADPH (nicotinamide adenine dinucleotide phosphate). In living cells, this small molecule is generated through metabolic processes, whereas its chemical production is very expensive; as a result, the commercial use of OYEs is thwarted.
OYEs from unicellular green algae: two birds with one stone
The research team from Bochum has discovered several OYEs in unicellular green algae. "For a broad application, industry needs OYEs that can also produce unusual molecules," explains Professor Thomas Happe, Head of the Photobiotechnology research group at RUB. "Algae possess very complex metabolic pathways and are therefore ideal sources for novel biocatalysts." The researchers analysed algal OYEs in the test tube and showed that they are able to convert many commercially viable substances. "The exciting thing is that living algae can also carry out the reactions needed in the industry," points out PhD student Stefanie Böhmer, lead author of the study. "Since algae produce NADPH using photosynthesis, i.e. with sunlight, the co-substrate of the OYEs is supplied in an environmentally friendly and cost-effective way."
Promising collaboration
The authors point out that the study demonstrates the importance of the collaboration between researchers from different disciplines, and that the industry can be a valuable partner who initiates basic research. Four researches from the Research Training Group "Micon - Microbial substrate conversion", which is funded by the German Research Foundation, contributed their expertise to the study. The project was the brainchild of Solarbioproducts Ruhr, a spin-off established by Wirtschaftsförderungsgesellschaft Herne and Thomas Happe with the aim of developing concepts for environmentally friendly algae biotechnologies. "We have taken a big step towards a green industry," concludes Happe. "This would not have been possible without collaboration."
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Funding
The study was funded by the German Research Foundation in the Research Training Group GRK 2341 Microbial Substrate Conversion Micon, the Chembiocat project funded by the Ministry of Innovation, Science and Research NRW, and Wirtschaftsförderungsgesellschaft Herne.
Original publication
Stefanie Böhmer, Christina Marx, Álvaro Gómez-Baraibar, Marc M. Nowaczyk, Dirk Tischler, Anja Hemschemeier, Thomas Happe: Evolutionary diverse Chlamydomonas reinhardtii old yellow enzymes reveal distinctive catalytic properties and potential for whole-cell biotransformations, in: Algal Research, 2020, DOI: 10.1016/j.algal.2020.101970

Typhoon changed earthquake patterns

Intensive erosion influenced seismicity
GFZ GEOFORSCHUNGSZENTRUM POTSDAM, HELMHOLTZ CENTRE
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IMAGE: IMAGES FROM A SATELLITE (LANDSAT) SHOW MASSIVE EROSION AFTER THE TYPHOON MORAKOT HIT TAIWAN. THIS INFLUENCED SEISMICITY IN THE AFFECTED REGIONS. view more 
CREDIT: NASA/LANDSAT
The Earth's crust is under constant stress. Every now and then this stress is discharged in heavy earthquakes, mostly caused by the slow movement of Earth's crustal plates. There is, however, another influencing factor that has received little attention so far: intensive erosion can temporarily change the earthquake activity (seismicity) of a region significantly. This has now been shown for Taiwan by researchers from the GFZ German Research Centre for Geosciences in cooperation with international colleagues. They report on this in the journal Scientific Reports.
The island in the western Pacific Ocean is ah the edge of the Asian continent. 11 years ago, Typhoon Morakot reached the coast of Taiwan. This trnyway one of the most tectonically active regions in the world, as the Philippine Sea Plate collides witopical cyclone is considered the one of the worst in Taiwan's recorded history.
Within only three days in August 2009, three thousand litres of rain fell per square metre. As a comparison, Berlin and Brandenburg receive an average of around 550 liters per square meter in one year. The water masses caused catastrophic flooding and widespread landsliding. More than 600 people died and the immediate economic damage amounted to the equivalent of around 3 billion euros.
The international team led by Philippe Steer of the University of Rennes, France, evaluated the earthquakes following this erosion event statistically. They showed that there were significantly more small-magnitude and shallow earthquakes during the 2.5 years after typhoon Morakot than before, and that this change occurred only in the area showing extensive erosion. GFZ researcher and senior author Niels Hovius says: "We explain this change in seismicity by an increase in crustal stresses at shallow depth, less than 15 kilometres, in conjunction with surface erosion". The numerous landslides have moved enormous loads, rivers transported the material from the devastated regions. "The progressive removal of these loads changes the state of the stress in the upper part of the Earth's crust to such an extent that there are more earthquakes on thrust faults," explains Hovius.
So-called active mountain ranges, such as those found in Taiwan, are characterized by "thrust faults" in the underground, where one unit of rocks moves up and over another unit. The rock breaks when the stress becomes too great. Usually it is the continuous pressure of the moving and interlocking crustal plates that causes faults to move. The resulting earthquakes in turn often cause landslides and massively increased erosion. The work of the GFZ researchers and their colleagues now shows for the first time that the reverse is also possible: massive erosion influences seismicity - and does so in a geological instant. Niels Hovius: "Surface processes and tectonics are connected in the blink of an eye." The researcher continues: "Earthquakes are among the most dangerous and destructive natural hazards. Better understanding earthquake triggering by tectonics and by external processes is crucial for a more realistic assessment of earthquake hazards, especially in densely populated regions."
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Original study: Steer, P. et al. "Earthquake statistics changed by typhoon-driven erosion"; Scientific Reports; DOI: 10.1038/s41598-020-67865-y

Science fiction becomes fact -- Teleportation helps to create live musical performance

UNIVERSITY OF PLYMOUTH


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IMAGE: DR ALEXIS KIRKE (RIGHT) AND SOPRANO JULIETTE POCHIN DURING THE FIRST DUET BETWEEN A LIVE SINGER AND A QUANTUM SUPERCOMPUTER view more 
CREDIT: UNIVERSITY OF PLYMOUTH

Teleportation is most commonly the stuff of science fiction and, for many, would conjure up the immortal phrase "Beam me up Scotty".
However, a new study has described how its status in science fact could actually be employed as another, and perhaps unlikely, form of entertainment - live music.
Dr Alexis Kirke, Senior Research Fellow in the Interdisciplinary Centre for Computer Music Research at the University of Plymouth (UK), has for the first time shown that a human musician can communicate directly with a quantum computer via teleportation.
The result is a high-tech jamming session, through which a blend of live human and computer-generated sounds come together to create a unique performance piece.
Speaking about the study, published in the current issue of the Journal of New Music Research, Dr Kirke said: "The world is racing to build the first practical and powerful quantum computers, and whoever succeeds first will have a scientific and military advantage because of the extreme computing power of these machines. This research shows for the first time that this much-vaunted advantage can also be helpful in the world of making and performing music. No other work has shown this previously in the arts, and it demonstrates that quantum power is something everyone can appreciate and enjoy."
Quantum teleportation is the ability to instantaneously transmit quantum information over vast distances, with scientists having previously used it to send information from Earth to an orbiting satellite over 870 miles away.
In the current study, Dr Kirke describes how he used a system called MIq (Multi-Agent Interactive qgMuse), in which an IBM quantum computer executes a methodology called Grover's Algorithm.
Discovered by Lov Grover at Bell Labs in 1996, it was the second main quantum algorithm (after Shor's algorithm) and gave a huge advantage over traditional computing.
In this instance, it allows the dynamic solving of musical logical rules which, for example, could prevent dissonance or keep to ¾ instead of common time.
It is significantly faster than any classical computer algorithm, and Dr Kirke said that speed was essential because there is actually no way to transmit quantum information other than through teleportation.
The result was that when played the theme from Game of Thrones on the piano, the computer - a 14-qubit machine housed at IBM in Melbourne - rapidly generated accompanying music that was transmitted back in response.
Dr Kirke, who in 2016 staged the first ever duet between a live singer and a quantum supercomputer, said: "At the moment there are limits to how complex a real-time computer jamming system can be. The number of musical rules that a human improviser knows intuitively would simply take a computer too long to solve to real-time music. Shortcuts have been invented to speed up this process in rule-based AI music, but using the quantum computer speed-up has not be tried before. So while teleportation cannot move information faster than the speed of light, if remote collaborators want to connect up their quantum computers - which they are using to increase the speed of their musical AIs - it is 100% necessary. Quantum information simply cannot be transmitted using normal digital transmission systems."
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Prospective teachers misperceive Black children as angry

Study findings suggest ramifications for Black youth
AMERICAN PSYCHOLOGICAL ASSOCIATION
Prospective teachers appear more likely to misperceive Black children as angry than white children, which may undermine the education of Black youth, according to new research published by the American Psychological Association.
While previous research has documented this effect in adults, this is the first study to show how anger bias based on race may extend to teachers and Black elementary and middle-school children, said lead researcher Amy G. Halberstadt, PhD, a professor of psychology at North Carolina State University. The study was published online in the APA journal Emotion.
"This anger bias can have huge consequences by increasing Black children's experience of not being 'seen' or understood by their teachers and then feeling like school is not for them," she said. "It might also lead to Black children being disciplined unfairly and suspended more often from school, which can have long-term ramifications."
In the study, 178 prospective teachers from education programs at three Southeastern universities viewed short video clips of 72 children ages 9 to 13 years old. The children's faces expressed one of six basic emotions: happiness, sadness, anger, fear, surprise or disgust. The clips were evenly divided among boys or girls and Black children or white children. The sample was not large enough to determine whether the race or ethnicity of the teachers made a difference in how they perceived the children.
The prospective teachers were somewhat accurate at detecting the children's emotions, but they also made some mistakes that revealed patterns. Boys of both races were misperceived as angry more often than Black or white girls. Black boys and girls also were misperceived as angry at higher rates than white children, with Black boys eliciting the most anger bias.
Anger bias against Black children can have many negative consequences. While controlling for other factors, previous research has found that Black children are three times more likely to be suspended or expelled from school than white children. Black children's negative experiences at school also could contribute to the disparate achievement gap between Black and white youth that has been documented across the United States, Halberstadt said.
Those in the study also completed questionnaires relating to their implicit and explicit racial bias, but their scores on those tests didn't affect the findings relating to Black children. However, those who displayed greater racial bias were less likely to misperceive white children as angry.
"Even when people are motivated to be anti-racist, we need to know the specific pathways by which racism travels, and that can include false assumptions that Black people are angry or threatening," Halberstadt said. "Those common racist misperceptions can extend from school into adulthood and potentially have fatal consequences, such as when police officers kill unarmed Black people on the street or in their own homes."
Previous research with adults in the United States has found that anger is perceived more quickly than happiness in Black faces, while the opposite effect was found for white faces. Anger also is perceived more quickly and for a longer time in young Black men's faces than young white men's faces.
"Over the last few weeks, many people are waking up to the pervasive extent of systemic racism in American culture, not just in police practices but in our health, banking and education systems," Halberstadt said. "Learning more about how these problems become embedded in our thought processes is an important first step."
Participants in the study were predominantly female (89%) and white (70%), mirroring the gender and race of most public-school teachers across the country. The study didn't include enough people of color from any single race or ethnicity (Hispanic 9%, Asian 8%, Black 6%, Biracial 5%, Native American 1%, and Middle Eastern 1%) to analyze separate findings based on the race or ethnicity of the participants.
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Article: "Racialized Emotion Recognition Accuracy and Anger Bias of Children's Faces," by Amy G. Halberstadt, PhD, Alison N. Cooke, PhD, Dejah Oertwig, MA, and Shevaun D. Neupert, PhD, North Carolina State University; Sherick Hughes, PhD, University of North Carolina-Chapel Hill; and Pamela W. Garner, PhD, George Mason University, Emotion, published online July 2, 2020.
Full text of the article can be found online at https://www.apa.org/pubs/journals/releases/emo-emo0000756.pdf.
Contact: Amy G. Halberstadt, PhD, may be contacted at Amy_Halberstadt@ncsu.edu.
The American Psychological Association, in Washington, D.C., is the largest scientific and professional organization representing psychology in the United States. APA's membership includes nearly 121,000 researchers, educators, clinicians, consultants and students. Through its divisions in 54 subfields of psychology and affiliations with 60 state, territorial and Canadian provincial associations, APA works to advance the creation, communication and application of psychological knowledge to benefit society and improve people's lives.
HERBALISM

In mouse study, black raspberries show promise for reducing skin inflammation

Early findings indicate eating the fruit could help with skin allergies
OHIO STATE UNIVERSITY
COLUMBUS, Ohio - Eating black raspberries might reduce inflammation associated with skin allergies, a new study indicates.
In a study done with mice and published earlier this month in the journal Nutrients, researchers found that a diet high in black raspberries reduced inflammation from contact hypersensitivity - a condition that causes redness and inflammation in the skin.
"A lot of times, treatments are directly applied to the skin - things like steroids," said Steve Oghumu, senior author on the paper and an assistant professor of pathology at The Ohio State University.
"And it was interesting that the mere consumption of a fruit can achieve the same effects."
The researchers put a group of mice on a diet that incorporated black raspberries - equivalent to a single serving per day for humans. They also kept a control group, where mice were fed the same diet, but without black raspberries.
Three weeks after the diets began, the researchers exposed one of each mouse's ears to irritants that caused contact hypersensitivity. Then, they measured the reductions in swelling, comparing the ears of each mouse.
They found that in mice fed a diet that included black raspberries, swelling went down compared to the mice that did not eat black raspberries.
The researchers found that the black raspberries appear to modulate dendritic cells, which act as messengers to the body's immune system, telling the immune system to kick in or not - essentially whether to create inflammation or not.
"The immune system is very complex, with multiple players, and so once you begin to identify the unique cells that are being affected by the berries then it helps us to see how berries are inhibiting inflammation," Oghumu said. "A lot of the bad effects that we see are not always due to the pathogens or allergens themselves, but are due to the way our body responds to these triggers."
In the case of contact hypersensitivity, for example, a person's skin encounters an allergen and the body responds by flooding the area with cells that cause inflammation and itchiness.
"And so one way to manage these types of diseases is controlling that response, and that is one of the things black raspberries appear to be able to do," he said.
Oghumu and colleagues in his lab have been studying the effects of black raspberries on inflammation for years. A diet rich in black raspberries has shown promise in reducing inflammation associated with some types of cancer, and Oghumu and his team have wondered if fruit might also help reduce inflammation in other conditions.
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This study is an early indication that those benefits might exist, Oghumu said. He noted that more work needs to be done to determine what specific properties of black raspberries lead to a decrease in inflammation.
This work was funded by an internal grant from the Ohio State Foods for Health initiative. Other Ohio State researchers on this study include Kelvin Anderson, Nathan Ryan, Arham Siddiqui, Travis Pero, Greta Volpedo and Jessica L. Cooperstone.

A scientific measure of dog years

CELL PRESS NEWS RELEASE 
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IMAGE: THIS GRAPHIC DEPICTS THE EPIGENETIC TRANSLATION FROM DOG AGE TO HUMAN AGE. view more 
CREDIT: IDEKER LAB, UC SAN DIEGO
How old is your tail-wagging bundle of joy in human years? According to the well-known "rule of paw," one dog year is the equivalent of 7 years. Now, in a study published July 2, in the journal Cell Systems, scientists say it's wrong. Dogs are much older than we think, and researchers devised a more accurate formula to calculate a dog's age based on the chemical changes in the DNA as organisms grow old.
Dogs share the same environment as their owners and receive almost the same standard of health care as humans, providing a unique opportunity for scientists to understand aging across species. Like humans, dogs follow similar developmental trajectories that lead them to grey and become more susceptible to age-related diseases over time. However, how they age on a molecular level is more complicated--aging rapidly at first and slowing down later in life.
"In terms of how physiologically mature a 1-year-old dog is, a 9-month-old dog can have puppies. Right away, you know that if you do the math, you don't just times seven," says senior author Trey Ideker (@TreyIdeker) of the University of California, San Diego. "What's surprising is exactly how old that one-year-old dog is--it's like a 30-year old human."
Human and dog DNA, which codes who we are, doesn't change much throughout the course of life, but chemical marks on the DNA, called methylation marks, do. Ideker considers these marks like wrinkles in the genome. "I tend to think of it very much like when you look at someone's face and guess their age based on their wrinkles, gray hair, and other features," he says. "These are just similar kinds of features on the molecular level."
The researchers studied 104 Labrador retrievers spanning from few-week-old puppies to 16-year-old dogs with the help of two canine experts, Danika Bannasch of the University of California, Davis, and Elaine Ostrander of the National Institutes of Health. They compared the changes in the methylation pattern to humans.
The comparison revealed a new formula that better matches the canine-human life stages: human age = 16 ln(dog age) + 31. Based on the new function, an 8-week-old dog is approximately the age of a 9-month-old baby, both being in the infant stage where puppies and babies develop teeth. The average 12-year lifespan of Labrador retrievers also corresponds to the worldwide life expectancy of humans, 70 years.
"I like to take my dogs on runs, and so I'm a little bit more sympathetic to the 6-year-old now," says Ideker, who realized that his dog is pushing 60 according to the new calculation.
In both species, they found that the age-driven methylation largely happens in developmental genes that are hotly fired up to create body plans in utero and regulating childhood development. By the time one becomes an adult and stops growing, "you've largely shut off these genes, but they're still smoldering," says Ideker. "If you look at the methylation marks on those developmental genes, they're still changing."
Focusing on the smoldering developmental genes, the team developed a clock that can measure age and physiological states across different species, while other methylation-quantifying age-predicting methods only do well in one species. Ideker also noted that future investigation in different dog breeds with various lifespans could provide more insight into the new clock. The clock may not only serve as a tool to understand cross-species aging but also apply as clinical practice for veterinarians to take proactive steps to treat animals.
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This work is supported by the following: the California Institute for Regenerative Medicine, the National Institute for Environmental Health Sciences, the National Institute of General Medical Sciences, the National Institute on Aging, the National Institute of Dental and Craniofacial Research, the Maxine Adler Endowed Chair Funds, and the Intramural Program of the National Human Genome Research Institute.
Cell Systems, Wang et al.: "Quantitative Translation of Dog-to-Human Aging by Conserved Remodeling of the DNA Methylome" https://www.cell.com/cell-systems/fulltext/S2405-4712(20)30203-9
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