Wednesday, February 15, 2023

NIH scientists develop mouse model to study mpox virulence

Peer-Reviewed Publication

NIH/NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

mpox virus particles 

IMAGE: COLORIZED TRANSMISSION ELECTRON MICROGRAPH OF MPOX VIRUS PARTICLES (YELLOW) CULTIVATED AND PURIFIED FROM CELL CULTURE. IMAGE CAPTURED AT THE NIAID INTEGRATED RESEARCH FACILITY (IRF) IN FORT DETRICK, MARYLAND. view more 

CREDIT: NIAID

WHAT:
Scientists from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have removed a major roadblock to better understanding of mpox (formerly, monkeypox). They developed a mouse model of the disease and used it to demonstrate clear differences in virulence among the major genetic groups (clades) of mpox virus (MPXV). The research, appearing in Proceedings of the National Academy of Science, was led by Bernard Moss, M.D., Ph.D., chief of the Genetic Engineering Section of NIAID’s Laboratory of Viral Diseases.

Historically, mpox, a disease resembling smallpox, was only occasionally transmitted from rodents to non-human primates or people and was observed primarily in several African countries. Mpox rarely spread from person to person. That pattern changed in 2022 with an outbreak in which person-to-person mpox transmission occurred in more than 100 locations worldwide. To date, more than 80,000 cases of mpox have been diagnosed during this outbreak. Genome sequencing revealed that the strain causing the current outbreak, clade IIb, differs from two historic clades; clade I, which has a mortality rate of up to 10%, and clade IIa, which has a mortality rate of less than 1%. Mortality from clade IIb MPXV is lower than either of the historic clades. 

Standard inbred laboratory mice are resistant to MPXV infection, and the absence of a small animal model of mpox has made it difficult to study how genetic differences contribute to observed differences in virulence. Dr. Moss and his colleagues identified a strain of wild-derived, inbred lab mouse (CAST/EiJ) and determined that these mice can be infected with MPXV. As in people, clade I was the most virulent in CAST mice, followed by clade IIa, then clade IIb. Unexpectedly, clade IIb virus was 100 times less virulent than clade IIa virus in mice and led to very little viral replication and much lower virulence than either of the historic clades. No mice died of clade IIb infection, despite exposure to extremely large doses of virus. Together, the results suggest that clade IIb is evolving diminished virulence or adapting to other species, the researchers conclude.

ARTICLE:
JL Americo et al. Virulence differences of mpox (monkeypox) virus clades I, IIa, and IIb.1 in a small animal model. PNAS DOI: 10.1073/pnas.2220415120 (2023).


NIAID conducts and supports research—at NIH, throughout the United States, and worldwide—to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the NIAID website.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov/.

NIH...Turning Discovery Into Health®
 

Climate change portends wider malaria risk as mosquitos spread south and to higher elevations in Africa

Peer-Reviewed Publication

GEORGETOWN UNIVERSITY MEDICAL CENTER

WASHINGTON — Based on data that span the past 120 years, scientists at Georgetown University Medical Center have found that the mosquitoes responsible for transmitting malaria in Africa are spreading deeper into southern Africa and to higher elevations than previously recorded. The researchers estimate that Anopheles mosquito populations in sub-Saharan Africa have gained an average of 6.5 meters (21 feet) of elevation per year, and the southern limits of their ranges moved south of the equator by 4.7 kilometers (nearly 3 miles) per year.

The study appeared February 15, 2023, in Biology Letters. 

“This is exactly what we would expect to see if climate change is helping these species reach colder parts of the continent,” says Colin Carlson, PhD, an assistant research professor at the Center for Global Health Science and Security at Georgetown University Medical Center and lead author of the study. “If mosquitoes are spreading into these areas for the first time, it might help explain some recent changes in malaria transmission that have otherwise been hard to trace back to climate.”

The world is at least 1.2 degrees Celsius (about 2 degrees Fahrenheit) warmer than in the pre-industrial period. In 2011, scientists estimated that earth-bound species were moving uphill at a rate of 1.1 meters per year, and to more polar latitudes at 1.7 kilometers per year, making the movement of mosquitoes a relatively fast shift by comparison.

The investigators focused on mosquitoes in the genus Anopheles both because of their ability to spread malaria, and because of a unique historical dataset tracking their movements. Carlson notes that other species are probably moving in similar ways, but that future research efforts will have to get a sense of what’s happening in different regions or with different diseases to gain the most comprehensive picture possible.

“We tend to assume that these shifts are happening all around us, but the evidence base is fairly limited,” says Carlson. “If we’re reimagining bio-surveillance for life on a hotter planet, a big part of that is going to have to be keeping an eye on animal movement.”

Carlson notes that his team has been learning a lot about long-term biodiversity change thanks to deep historical public health records. “We know so little about how climate change is affecting invertebrate biodiversity. Public health is giving us a rare window into how some insects might be thriving in a changing climate—even if it’s bad news for humans.”

###

All study authors are at Georgetown University and include Colin Carlson, Ellen Bannon, Emily Mendenhall, Timothy Newfield and Shweta Bansal.

The authors report having no personal financial interests related to the study. No original data was used in this study as the Anopheles dataset is freely available from previously published research.

About Georgetown University Medical Center

As a top academic health and science center, Georgetown University Medical Center  provides, in a synergistic fashion, excellence in education — training physicians, nurses, health administrators and other health professionals, as well as biomedical scientists — and cutting-edge interdisciplinary research collaboration, enhancing our basic science and translational biomedical research capacity in order to improve human health. Patient care, clinical research and education is conducted with our academic health system partner, MedStar Health. GUMC’s mission is carried out with a strong emphasis on social justice and a dedication to the Catholic, Jesuit principle of cura personalis -- or “care of the whole person.” GUMC comprises the School of Medicine, the School of Nursing, School of Health, Biomedical Graduate Education, and Georgetown Lombardi Comprehensive Cancer Center. Designated by the Carnegie Foundation as a doctoral university with "very high research activity,” Georgetown is home to a Clinical and Translational Science Award from the National Institutes of Health, and a Comprehensive Cancer Center designation from the National Cancer Institute. Connect with GUMC on Facebook (Facebook.com/GUMCUpdate) and on Twitter (@gumedcenter).

 

 

USC study: Concern about water driven more by concerns about severe weather than climate change


Outcome suggests warning people about water safety and other environmental threats is more effective when linked to extreme weather, not climate change.

Peer-Reviewed Publication

UNIVERSITY OF SOUTHERN CALIFORNIA

Climate change and worsening severe weather events pose increasing threats to global water safety, with limited access to safe water projected to impact approximately 5 billion people worldwide by the year 2050, according to the United Nations.

But researchers have found that people don’t always see the links between climate change and water safety, which may undermine efforts to implement behaviors that improve water safety.

In a new study published in Environmental Science & Technology, researchers with the USC Sol Price School of Public Policy, the USC Dornsife College of Letters, Arts and Sciences and WaterKeeper Alliance assessed the extent to which people’s concern for severe weather and climate change predict their concern for water safety, which refers to the quality of drinking water.

Using survey data from the 2019 Lloyd’s Register Foundation World Risk Poll, they found severe weather concern was significantly more predictive of concern for water safety than climate change concern, although both resulted in positive associations.

“It's easier for people to see that their water is being threatened by extreme weather than by the abstract notion of climate change,” said the corresponding author, Wändi Bruine de Bruin, Provost Professor of Public Policy, Psychology and Behavioral Science at the USC Price School and the USC Dornsife Department of Psychology. “Our study suggests if we want to warn people about water safety and other environmental threats, we should draw links to extreme weather.”

Previous studies on water safety risk perceptions have mostly been conducted in single-country contexts, limiting researchers’ ability to make comparisons across countries. The new analysis includes responses from 142 countries, including 21 low-income and 34 lower-middle-income countries.

Participants reported their concern that drinking water and severe weather could cause them serious harm, and the extent to which they perceived climate change as a serious threat to the people in their country in the next 20 years.

“If we want to do a better job of informing people about the risks to water safety from climate change with the ultimate goal of changing their attitudes and behaviors, we need to make it more personal for them,” said study co-author Dr. Joe Árvai, the Dana and David Dornsife Professor of Psychology and director of the Wrigley Institute for Environmental Studies at the USC Dornsife College. “As our study shows, that’s why talking about the important and real connections between local weather, climate and water is so important.”

“Communications need to make environmental issues concrete and personally relevant,” said Joshua Inwald, who is a USC Psychology PhD student and first author of the study. “Scientists and policy makers will be more effective if they keep this in mind.”

About the study

This research was supported by the Lloyd’s Register Foundation.

 

Canada’s first zero-carbon, net-positive energy building is on track to propel Ontario’s energy transition

Research shows how data and staff expertise play a vital role in ensuring sustainable buildings deliver on their promise to put clean energy back into the grid

Peer-Reviewed Publication

UNIVERSITY OF WATERLOO

Office buildings are typically not energy efficient, and globally they contribute to nearly a third of greenhouse gas emissions from construction to end of life. A new study out of the University of Waterloo analyzes data-driven improvements in Canada’s first zero-carbon, net-positive energy building showing how they play a vital role in that building generating more energy than it consumes.

In the first case study of its kind in Canada, researchers found that the net-positive building used more energy than originally predicted during the first nine months of operation while the operators were still learning about building systems. In 2019, the building failed to deliver on its promise to make enough solar power for its operations and some for the community. However, through continuous monitoring and implementing improvements, operations staff were able to reduce the building’s energy consumption by approximately 15 percent without compromising the comfort of people working in the space.

“The case study demonstrates that all buildings can experience operational inefficiencies – including environmentally friendly models,” said Monika Mikhail, a graduate student in the School of Environment, Enterprise and Development and lead researcher on this work. “Implementing data-driven improvements to finetune operations can help sustainably designed buildings achieve their promise to create clean energy for society.”

To address the performance gaps, operations staff upgraded selected equipment like pumps to distribute heat efficiently throughout the building. They also trialled new measures, such as adjusting the heating, ventilation, and air conditioning schedules for improvements. Adopting a mindset of continuous improvement paid off as the energy used to perform those tasks decreased. Now the net-positive building is on track to achieve its target in 2022, producing five percent more clean energy than its consumption and adding it to the Ontario grid. 

“We have the technology and tools to adapt to climate change, but they alone are not enough,” said Mikhail. “Leveraging the experience and expertise of building operations professionals and data analysis are critical to ensuring sustainability targets are met.” 

In the future, the researchers hope that the findings will inspire other building owners to go beyond producing just their energy quota (net-zero energy) and aim to reach net-positive energy.

“The surplus clean energy can offset the embedded carbon from construction and thus achieve zero-carbon performance, an essential step toward achieving our national carbon targets,” said Paul Parker, professor at the School of Environment, Enterprise and Development. “This effort will require strong collaboration between many stakeholder groups, including designers, operators and funding bodies.” 

The study, Net-positive office commissioning and performance gap assessment: Empirical insights, appears in the journal Energy & Buildings

Decades of conflict in Iraq have fuelled “catastrophic” rise in antibiotic resistance

Serious implications for the entire region and the world, warn experts. Destroyed healthcare infrastructure, medicine shortages, limited resources, heavy metal contamination, poor sanitation likely to blame

Peer-Reviewed Publication

BMJ

Decades of wars and conflict in Iraq have led to a “catastrophic” rise in antibiotic resistance in the country, with serious implications for the entire region and the world, warn international experts in the open access journal BMJ Global Health.

The combination of destroyed healthcare infrastructure, medicine shortages, limited resources, high levels of heavy metal contamination, and poor sanitation is likely to blame, they argue.

Antibiotic resistance, or AMR for short, is rising globally at an alarming rate and is expected to cause 10 million deaths a year by 2050, if nothing is done about it, point out the authors.

Largely attributed to the overuse and misuse of antibiotics, attention is now turning to other factors, such as heavy metals and disinfectants containing quaternary ammonium compounds (QACs), which are widely used in the healthcare and hospitality sectors.

War has been implicated in the emergence of AMR as far back as the 1940s, but has received little attention, say the authors.

Iraq is a stellar example of this neglect, as the country has experienced a sequence of conflicts since the 1980s that have coincided with the emergence and spread of pathogens with specific patterns of antibiotic resistance, they highlight.

These conflicts include the Iran-Iraq war (1980–88); the First Gulf War in 1991; United Nations economic sanctions following the Iraqi invasion of Kuwait (1990- 2003); the US invasion and occupation (2003–11), including a period of militarised violence (2005-07); and Iraqi state conflicts with ISIS (Islamic State of Iraq and Syria) in 2014–17.

“Contemporary conflicts, waged in urban and industrialised landscapes, pressure microbes with selective environments that contain unique combinations and concentrations of toxic heavy metals and antibiotics, while simultaneously providing niches and dissemination routes for microbial pathogens,” the authors write. 

“These can include the high number of wounded, the nature of wounds, refugee displacement, collapse of sanitation controls, loss of diagnostics and skilled healthcare personnel, the dismantlement of healthcare infrastructures and the placement of often under-resourced and improvised field hospitals where both injured combatants and civilians are exposed to harmful pathogens with limited care and resources to properly recover.”

Such outcomes have occurred in Iraq, say the authors.

Heavy metals used in weapons persist in the environment, with explosives harbouring huge amounts of lead and mercury. Chromium, copper, lead nickel and zinc are used to coat bullets, missiles, gun barrels and military vehicles, while antimony, barium, and boron are weapon-priming compounds. And many bacterial species have been shown to have evolved resistance to combat heavy metals’ toxicity. 

“Taken together, a destroyed healthcare infrastructure, inappropriate microbial therapies, limited resources, high heavy metal contamination in humans and the environment,and lack of [proper water, sanitation and hygiene], combined, likely play instrumental roles in the catastrophic rise of AMR in Iraq and, by extension, regionally and globally,” the authors write.

Research is urgently needed to understand the direct and indirect roles of armed conflict on the rise of AMR if it is to be stopped and millions of needless deaths prevented, they insist.

“Understanding these linkages between AMR and conflict, especially across time, is essential for a global response to AMR, especially as there is little indication that conflict, worldwide, will abate in years to come.”

 

Urban gardens are good for ecosystems and humans

Peer-Reviewed Publication

UNIVERSITY OF TEXAS AT AUSTIN

Urban Garden 

IMAGE: URBAN GARDENS, LIKE THIS ONE IN CALIFORNIA, HAVE BEEN FOUND TO BENEFIT LOCAL ECOSYSTEMS AS WELL AS HUMANS. view more 

CREDIT: UNIVERSITY OF CALIFORNIA

Traditionally, it has been assumed that cultivating food leads to a loss of biodiversity and negative impacts on an ecosystem. A new study from researchers at multiple universities, including The University of Texas at Austin, defies this assumption, showing that community gardens and urban farms positively affect biodiversity, local ecosystems and the well-being of humans that work in them.

The study, published in Ecology Letters, looked at 28 urban community gardens across California over five years and quantified biodiversity in plant and animal life, as well as ecosystem functions such as pollination, carbon sequestration, food production, pest control and human well-being.

“We wanted to determine if there were any tradeoffs in terms of biodiversity or impacts on ecosystem function,” said Shalene Jha, an associate professor of integrative biology who was lead author on the paper. “What we found is that these gardens, which are providing tremendous nutritional resources and increasing well-being for gardeners, are also supporting incredibly high levels of plant and animal biodiversity. It’s a win-win.”

Previous assumptions by scientists about the negative effect of food production on biodiversity have been almost entirely based on intensive rural agriculture enterprises that tend to grow only one or two types of crops, often at a massive scale. Urban community gardens, private gardens, and urban farms and orchards tend to grow more types of plants in smaller areas. This new study is the first to explore the effects of urban gardens across a wide range of biodiversity measures and ecological services.

“It’s estimated that by 2030, about 60% of the world’s population will live in cities,” Jha said. “And urban farms and gardens currently provide about 15%-20% of our food supply, so they are essential in addressing food inequality challenges. What we’re seeing is that urban gardens present a critical opportunity to both support biodiversity and local food production.”

The study also found that the choices that gardeners make can have a large impact on their local ecosystem. For instance, planting trees outside crop beds could increase carbon sequestration without limiting pollinators or decreasing food production from too much shade. And mulching only within crop beds could help improve soil carbon services, while avoiding negative effects on pest control and pollinators.

The research was funded by the U.S. Department of Agriculture’s National Institute of Food and Agriculture, the National Science Foundation, and grants from the University of California. Monika Egerer, Peter Bichier, Hamutahl Cohen, Stacy M. Philpott and Azucena Lucatero of UC Santa Cruz, Heidi Liere of Seattle University and Brenda Lin of CSIRO Land and Water Flagship in Australia were co-authors of the study.

A green sweat bee on a native wildflower.

CREDIT

University of California

Coral reefs in the Eastern Pacific could survive into the 2060s, new study finds

Some reefs increase their resilience to elevated temperatures by being built by corals that shuffle algal partners following ocean heatwaves

Peer-Reviewed Publication

UNIVERSITY OF MIAMI ROSENSTIEL SCHOOL OF MARINE, ATMOSPHERIC, AND EARTH SCIENCE

Coral Reefs in the Eastern Pacific Could Survive into the 2060s, New Study Finds 

IMAGE: ANA PALACIO, PH.D., LEAN AUTHOR OF THE STUDY. SURVEYS A CORAL REEF IN THE EASTERN PACIFIC DOMINATED BY POCILLOPORA CORALS. view more 

CREDIT: VIKTOR BRANDTNERIS

Scientists at the University of Miami Rosenstiel School of Marine, Atmospheric, and Earth Science found that some reefs in the tropical Pacific Ocean could maintain high coral cover into the second half of this century by shuffling the symbiotic algae they host. The findings offer a ray of hope in an often-dire picture of the future of coral reefs worldwide.

While global warming is causing the loss of coral reefs globally, scientists believe that some corals are increasing their tolerance to heat by changing the symbiotic algae communities they host, which through photosynthesis provide them with the energy they need to live.

“Our results suggest that some reefs in the eastern tropical Pacific, which includes the Pacific coasts of Panama, Costa Rica, Mexico, and Colombia, might be able to maintain high coral cover through the 2060s,” said coral biologist Ana Palacio-Castro, lead author of the study, alumna of the Rosenstiel School, and a postdoctoral associate at the school’s Cooperative Institute for Marine and Atmospheric Studies. “However, while this may be seen as good news for these reefs, their survival may not continue past that date unless we reduce global greenhouse gas emissions and curtail global warming on a larger scale.”

Shallow coral reefs in the eastern tropical Pacific Ocean are predominantly built by branching corals in the genus Pocillopora, which are extremely important for the reefs in the region. The microscopic algae they host in their tissue harvest light to help the coral produce energy to grow. The loss of these symbiotic algae causes the coral to turn white, or bleach, and the coral struggles to meet their energy needs, which can often prove fatal. 

To better understand how corals improved their tolerance to heat stress, the researchers examined over 40 years’ worth of coral reef-monitoring data from Panama, one of the longest datasets of its kind in the world. They analyzed temperature, coral cover, bleaching and mortality data spanning three ocean heatwaves – in 1982–1983, 1997–1998, and 2015–2016 – along with data on algal symbiont community data during the last two.

The analysis showed that the 1982-83 heatwave significantly reduced coral cover on the reef, but the effects of the 1997-98 and 2015-16 El Niño were milder, especially for corals in the genus Pocillopora — sometimes known as cauliflower coral — the predominant reef-building coral in the eastern tropical Pacific. They also confirmed that during strong ocean heatwaves, the heat-tolerant alga Durusdinium glynnii becomes increasingly common in this particular lineage of corals, allowing them to better withstand periods of elevated temperatures. When combined with climate projections of future heat stress, the reefs that were predominantly composed of Pocillopora corals and that hosted this heat-tolerant alga were found to be better equipped to survive and maintain high levels of coral cover well into the second half of the current century, indicating that some reef systems may be more resilient to warming than previously thought.

“This study shows that there are some unusual reefs that may be able to survive for several decades as a result of their ability to shuffle symbionts,” said Andrew Baker, professor of marine biology and ecology at the Rosenstiel School, and senior author of the study. “While we don’t think that most reefs will be able to survive in this way, it does suggest that vestiges of our current reefs may persist for longer than we previously thought, although potentially with many fewer species. Coral reefs are incredibly valuable natural assets, providing coastal protection and fisheries benefits, and supporting many local communities. We can still make a difference by protecting them.”

The study, titled “Increased dominance of heat-tolerant symbionts creates resilient coral reefs in near-term ocean warming,” was published on Feb.13, 2023, in the journal PNAS. The study’s authors include: Ana M. Palacio-Castro, University of Miami Rosenstiel School of Marine, Atmospheric, and Earth Science, Cooperative Institute for Marine and Atmospheric Studies and NOAA Atlantic Oceanographic and Meteorological Laboratory; Andrew C. Baker, Grace A. Snyder and Peter W. Glynn, University of Miami Rosenstiel School; Tyler B. Smith and Viktor Brandtneris, Center for Marine and Environmental Studies, University of the Virgin Islands; Ruben van Hooidonk, Cooperative Institute for Marine and Atmospheric Studies and NOAA Atlantic Oceanographic and Meteorological Laboratory; Juan L. Maté, Smithsonian Tropical Research Institute; Derek Manzello, Coral Reef Watch, NOAA and Peggy Fong, University of California Los Angeles.

The study was supported by National Science Foundation (NSF) grants (OCE 1447306 and OCE-1358699) and COLCIENCIAS Scholarship for doctoral studies abroad (#529).

 

About the University of Miami

The University of Miami is a private research university and academic health system with a distinct geographic capacity to connect institutions, individuals, and ideas across the hemisphere and around the world. The University’s vibrant and diverse academic community comprises 12 schools and colleges serving more than 17,000 undergraduate and graduate students in more than 180 majors and programs. Located within one of the most dynamic and multicultural cities in the world, the University is building new bridges across geographic, cultural, and intellectual borders, bringing a passion for scholarly excellence, a spirit of innovation, a respect for including and elevating diverse voices, and a commitment to tackling the challenges facing our world. Founded in the 1940’s, the Rosenstiel School of Marine, Atmospheric, and Earth Science is one of the world’s premier marine and atmospheric research institutions. Offering dynamic interdisciplinary academics, the Rosenstiel School is dedicated to helping communities to better understand the planet, participating in the establishment of environmental policies, and aiding in the improvement of society and quality of life. www.earth.miami.edu.

Survivors of Utah’s eugenic sterilization program still alive in 2023

New study reveals scale of coerced sterilization in Utah

Peer-Reviewed Publication

UNIVERSITY OF UTAH

At least 830 men, women and children were coercively sterilized in Utah, approximately 54 of whom may still be alive. They were victims of a sterilization program that lasted for fifty years in the state and targeted people confined to state institutions. Many were teenagers or younger when operated upon; at least one child was under the age of ten.

“For the first time, we have a sense of the human scale of the eugenic assault here in Utah, as well as the lasting legacy of that assault in the form of survivors still living in 2023,” said James Tabery, a professor in the Department of Philosophy at the University of Utah and lead author of the paper reporting the results, which appeared today in The Lancet Regional Health - Americas.

Eugenics in America and in Utah

Utah was one of 32 states that passed legislation permitting the sterilization of people on eugenic grounds. The eugenic movement was popular across the United States in the early-20th century. It mixed pseudoscientific ideas about the existence of genes for complex traits like criminality and poverty with racist and ableist biases about what lives were worth living to make judgments about who in society was “fit” and worthy of bearing children and who was “unfit” and unworthy. All told, more than 60,000 people were sterilized across America as part of the effort to mold human populations into the eugenic ideal. 

Utah’s sterilization law was first passed in 1925, authorizing the sterilization of people institutionalized at the Utah State Hospital, Utah State Prison and Utah State Industrial School and deemed to be “habitually sexually criminal, insane, idiotic, imbecile, feeble-minded or epileptic, and by the laws of heredity is the probable parent of socially inadequate off-spring likewise afflicted.” When the Utah State Training School (now Utah State Developmental Center) opened in the early 1930s to care for the “feebleminded,” the law was revised to include patients there too.  

The Victims of Eugenic Sterilization

Tabery and his coauthors – Nicole Novak, assistant professor at the University of Iowa, as well as Lida Sarafraz and Aubrey Mansfield, two graduate students at the University of Utah – provide several examples of the terrible harm done by Utah’s sterilization program. In one case, when a teenage girl, in 1928, told her local religious leader that she’d been repeatedly raped by a family member, the man did not believe her. Instead, she was admitted to the Utah State Hospital, diagnosed as a “moron” and sterilized. After her release, that same man admitted she was probably being sold as a sex worker by another family member. In another case, in the 1970s, a teenage boy at the Utah State Training School learned that he was scheduled for sterilization. His initial reaction was violent objection, motivated by his desire to have children. As time went on, however, he resigned himself to the fact that there was little he could do to prevent the operation.

The paper, “Victims of Eugenic Sterilisation in Utah” documents how those tragic cases evolved over time. When the state-sanctioned sterilizations began in 1925, they occurred almost exclusively at the Utah State Hospital in Provo, UT and more often targeted men than women. When the Utah State Training School opened several years later, the vast majority of the sterilizations shifted to that institution in American Fork, UT, where the program captured a younger population and shifted to sterilizing more females than males. The institutionalized program peaked in Utah in the 1940s and didn’t end until 1974. 

Utah had a particularly aggressive sterilization program. Eugenics leaders, in fact, hailed Utah for sterilizing a far greater proportion of its residents than any other state in 1947 as an “important achievement in public health.”

The “Stubborn Persistence” of Sterilizations in Utah

“One striking feature of Utah’s sterilization program,” according to Tabery, “is just how long it lasted.” Many states ramped down their sterilization programs in the 1940s and 1950s. This was partly in response to the horrific revelations that came at the conclusion of World War II. Nazis in Germany eagerly embraced American eugenics, taking it to its grisly zenith by declaring entire racial and ethnic groups “unfit.” As concentration camps were uncovered across Europe, the shocking culmination of that eugenic vision became plain for all to see. There were also scientific forces working against eugenics. Human geneticists, by the mid-20th century, made it clear that there were no simple genes for criminality or poverty, and so no amount of sterilization would eliminate those problems from society.                              

The Utah legislature worked around those developments by changing the rationale for its sterilization program in 1961. With no biological support for the program, the lawmakers swapped out the genetic justification with a new rationale for sterilization, arguing that institutionalized people could be sterilized if they were deemed “unlikely to be able to perform properly the functions of parenthood.” As one Utah newspaper from the era summarized the legislative shift, “Instead of having to prove a genetic defect, it is now necessary only to show that a person is not and has no chance of becoming a fit parent.” 

Tabery and his co-authors describe the “stubborn persistence” of the sterilization program in Utah as particularly egregious. Intentionally seeking a lower scientific threshold for sterilizations allowed the program to continue well into the 1970s, long after many other states shuttered their eugenic initiatives.

A Nearly Complete Picture of Eugenic Sterilization in Utah

The publication includes demographic information (e.g. sex, race/ethnicity, year of birth) on almost every documented case of eugenic sterilization that took place in Utah. Of all the known cases that occurred, only about two dozen are missing from the data set, providing a nearly complete picture of who the eugenic program targeted over the years. 

This is particularly noteworthy because there was no single eugenics board overseeing the sterilizations in Utah. Instead, they were controlled by administrative staff at the state hospital, state prison and state training school. (The Utah State Industrial School, formerly of Ogden, UT, was authorized to perform sterilizations, but no procedures were recorded there.) 

Data for the study was derived from a deidentified database compiled by staff at the Utah State Developmental Center, as well as a masters thesis written by a University of Utah graduate student from 1932 which reported on cases of eugenic sterilization from that time. The research was funded by grants from the National Human Genome Research Institute at the U.S. National Institutes of Health. Neither the Utah state institutions nor the funder played any role in the design or administration of the study. 

Estimating the Number of Survivors Living in 2023

With information about sex, year of birth and age at sterilization, the research team was able to estimate the number of sterilizations survivors still living in 2023: approximately 54 (36 women and 18 men), with an average age of 78. 

Other states, when faced with their own abhorrent history of eugenics, have begun reckoning with that awful past. Governors and legislators have issued official apologies. Historical markers have been installed. Several states have even created compensation programs for the survivors of their programs. Utah, on the other hand, has expressed no such regret, lacking even an official acknowledgement of the history. 

Given the advanced age of potential survivors in Utah, Tabery and his co-authors conclude that “time is running out for a reconciliation that can be experienced by those who were most harmed by the medical practice.”

Leonardo da Vinci’s forgotten experiments explored gravity as a form of acceleration

Peer-Reviewed Publication

CALIFORNIA INSTITUTE OF TECHNOLOGY

Experiment recreation 

IMAGE: ENGINEERS AT CALTECH RECREATED THE EXPERIMENT DEPICTED IN LEONARDO DA VINCI'S JOURNAL, SHOWING THAT IF THE MOTION OF A PITCHER POURING OUT WATER OR GRANULAR MATERIAL IS ACCELERATED AT THE SAME RATE THAT GRAVITY ACCELERATES THE FALLING MATERIAL, IT CREATES AN EQUILATERAL TRIANGLE. view more 

CREDIT: CALTECH

Engineers from Caltech have discovered that Leonardo da Vinci’s understanding of gravity—though not wholly accurate—was centuries ahead of his time.

In an article published in the journal Leonardo, the researchers draw upon a fresh look at one of da Vinci’s notebooks to show that the famed polymath had devised experiments to demonstrate that gravity is a form of acceleration—and that he further modeled the gravitational constant to around 97 percent accuracy.

Da Vinci, who lived from 1452 to 1519, was well ahead of the curve in exploring these concepts. It wasn’t until 1604 that Galileo Galilei would theorize that the distance covered by a falling object was proportional to the square of time elapsed and not until the late 17th century that Sir Isaac Newton would expand on that to develop a law of universal gravitation, describing how objects are attracted to one another. Da Vinci’s primary hurdle was being limited by the tools at his disposal. For example, he lacked a means of precisely measuring time as objects fell.

Da Vinci’s experiments were first spotted by Mory Gharib, the Hans W. Liepmann Professor of Aeronautics and Medical Engineering, in the Codex Arundel, a collection of papers written by da Vinci that cover science, art, and personal topics. In early 2017, Gharib was exploring da Vinci’s techniques of flow visualization to discuss with students he was teaching in a graduate course when he noticed a series of sketches showing triangles generated by sand-like particles pouring out from a jar in the newly released Codex Arundel, which can be viewed online courtesy of the British Library

“What caught my eye was when he wrote ‘Equatione di Moti’ on the hypotenuse of one of his sketched triangles—the one that was an isosceles right triangle,” says Gharib, lead author of the Leonardo paper. “I became interested to see what Leonardo meant by that phrase.” 

To analyze the notes, Gharib worked with colleagues Chris Roh, at the time a postdoctoral researcher at Caltech and now an assistant professor at Cornell University, as well as Flavio Noca of the University of Applied Sciences and Arts Western Switzerland in Geneva. Noca provided translations of da Vinci’s Italian notes (written in his famous left-handed mirror writing that reads from right to left) as the trio pored over the manuscript’s diagrams.

In the papers, da Vinci describes an experiment in which a water pitcher would be moved along a straight path parallel to the ground, dumping out either water or a granular material (most likely sand) along the way. His notes make it clear that he was aware that the water or sand would not fall at a constant velocity but rather would accelerate—also that the material stops accelerating horizontally, as it is no longer influenced by the pitcher, and that its acceleration is purely downward due to gravity.

 

If the pitcher moves at a constant speed, the line created by falling material is vertical, so no triangle forms. If the pitcher accelerates at a constant rate, the line created by the collection of falling material makes a straight but slanted line, which then forms a triangle. And, as da Vinci pointed out in a key diagram, if the pitcher’s motion is accelerated at the same rate that gravity accelerates the falling material, it creates an equilateral triangle—which is what Gharib originally noticed that da Vinci had highlighted with the note “Equatione di Moti,” or “equalization (equivalence) of motions.” 

Da Vinci sought to mathematically describe that acceleration. It is here, according to the study’s authors, that he didn’t quite hit the mark. To explore da Vinci’s process, the team used computer modeling to run his water vase experiment. Doing so yielded da Vinci’s error.

“What we saw is that Leonardo wrestled with this, but he modeled it as the falling object’s distance was proportional to 2 to the t power [with t representing time] instead proportional to t squared,” Roh says. “It’s wrong, but we later found out that he used this sort of wrong equation in the correct way.” In his notes, da Vinci illustrated an object falling for up to four intervals of time—a period through which graphs of both types of equations line up closely.

“We don’t know if da Vinci did further experiments or probed this question more deeply,” Gharib says. “But the fact that he was grappling with this problem in this way—in the early 1500s—demonstrates just how far ahead his thinking was.”

The paper is titled “Leonardo da Vinci’s Visualization of Gravity as a Form of Acceleration.”