Tuesday, November 17, 2020

Greenland's largest glaciers likely to melt faster than feared: study

Issued on: 17/11/2020 - 
Over the last two decades, the world's ice sheets atop Greenland and Antarctica have become the single largest source of sea level rise
Jonathan NACKSTRAND AFP

Paris (AFP)

The three largest glaciers in Greenland -- which hold enough frozen water to lift global sea levels some 1.3 metres -- could melt faster than even the worst-case warming predictions, research published Tuesday showed.

Until 2000, the main driver of sea level rise was melting glaciers and the expansion of ocean water as it warms.

But over the last two decades, the world's ice sheets atop Greenland and Antarctica have become the single largest source of sea level rise.

A team of researchers based in Denmark and Britain used historical images and a host of other data to estimate how much ice had been lost from Greenland's Jakobshavn Isbrae, Kangerlussuaq Glacier and Helheim Glaciers in the 20th century.

They found that Jakobshavn Isbrae lost more than 1.5 trillion tonnes of ice between 1880-2012, while Kangerlussuaq and Helheim lost 1.4 trillion and 31 billion tonnes from 1900–2012, respectively.

The ice melt has already contributed more than eight millimetres to global sea levels, the researchers wrote.

Shfaqat Abbas Khan, a researcher at the Technical University of Denmark, said using photographs taken before the satellite era was another tool to help recreate the last century's ice loss.

"Historical measurements over the 19th and 20th century may hide important information that can significantly improve our future projections," he told AFP.

The UN's climate science advisory panel, the IPCC, has forecast sea level rise from all sources of between 30-110 centimetres by 2100, depending on emissions.

Under the IPCC's high emissions pathway, known as RCP8.5, nothing is done to curb carbon pollution throughout the 21st century, leading to a climate more than 3C hotter than pre-Industrial levels.

Models ran under RCP8.5 for the three glaciers featured in Tuesday's study predict a sea-level rise of 9.1–14.9mm by 2100.

But the paper, published in Nature Communications, pointed out that the high-emissions pathway temperature increase was more than four times larger than during the 20th Century, when the three glaciers already added 8mm to seas.

"The worst-case scenario is underestimated. Ice loss may be anywhere from three or four times larger than previous predicted for the thee glaciers considered in this study," said Khan.

A Nature study published in September found that if greenhouse gas emissions continued unabated, ice sheets in Greenland will shed some 36 trillion tonnes this century, enough to lift the global waterline some 10 centimetres.

© 2020 AFP


Report names and shames countries cosy with Big Tobacco

Issued on: 17/11/2020 - 
Tobacco claims some eight million lives each year from cancer and other lung diseases, a million in China alone 

PRAKASH SINGH AFP/File

Paris (AFP)

The global tobacco industry has aggressively lobbied governments during the Covid-19 pandemic to expand markets and blunt measures designed to curb their business, a report from watchdog groups aligned with the World Health Organization claimed on Tuesday.

A ranking of 57 countries based on their willingness to keep Big Tobacco at bay puts Japan and Indonesia at the bottom of the list, with Romania, China and Lebanon among the 10 worst offenders.

The United States is the lowest-ranked Western nation, with Malaysia, Spain, Germany and India also seen as too accommodating, said the report by non-profit groups based in France, England and Thailand.

"The tobacco industry has a well-documented history of deception and of capitalising on humanitarian crises, and it is using the pandemic to attempt to improve its deteriorating public image," commented Adriana Blanco Marquizo, head of the secretariat for the World Health Organization Framework Convention on Tobacco Control.

Tobacco claims some eight million lives each year from cancer and other lung diseases, a million in China alone.

In several countries, stringent tobacco control measures were defeated or diluted.

Philip Morris International (PMI), for example, "lobbied for the promotion and sale of its heated tobacco product in a dozen countries", resulting in the lifting of bans, lower taxes, and a voice in government-led deliberations on regulating tobacco products, the report found.

Taxes on these new nicotine delivery devices are now lower than cigarettes in France, Germany and Japan.

Costa Rica, Zambia and Bangladesh also eased the tax burden for tobacco firms.

Big Tobacco has a long track record of suing to block plain packaging for cigarettes, sponsoring cultural events or sports teams, and challenging the legality of smoke-free zones.

- $850 billion industry -

During the pandemic, tobacco firms have been handing out personal protective equipment, ventilators and hand sanitisers in countries across the world.

"While publicising its charitable acts to resuscitate its image as being part of the solution, the industry was simultaneously lobbying governments not to impose restrictions on its business," the report said.

In Kenya, the government listed tobacco products as "essential products" during the pandemic, and in Jordan cigarettes were delivered with bread and other foods directly to neighbourhoods.

By contrast, India and South Africa banned the sale of tobacco products during the pandemic.

More broadly, the countries seen as least susceptible to the influence of tobacco interests included France, Uganda, Britain, New Zealand and Iran.

Peru, The Netherlands, Kenya and Ethiopia also got good marks.

The report, releasee by the STOP partnership, was put together after former New York mayor Michael Bloomberg gave the researchers a three-year grant of $20 million to track how the industry markets its wares worldwide, especially in developing countries.

"This is the only product I know of where if you use it as advertised, it will kill you," Bloomberg told AFP in 2018, when he awarded the grant.

More than 80 percent of the world's 1.3 billion tobacco users live in low- and middle-income countries.

Smoking has plateaued in most rich nations, but in the developing world the total number of tobacco users -- overwhelmingly men, especially the young -- continues to climb.

The global tobacco market size was valued at nearly $850 billion in 2019.

The groups collaborating on the report included the Tobacco Research Group at the University of Bath, the Global Center for Good Governance in Tobacco Control and the International Union Against Tuberculosis and Lung Disease.

© 2020 AFP
Armenia looks to protect cultural artefacts amid conflict with Azerbaijan

Issued on: 17/11/2020 -
Armenian historians have secured hundreds of ancient manuscripts from Nagorno-Karabakh. © FRANCE 24 screengrab
Text by:FRANCE 

Video by:Luke SHRAGO|Romeo LANGLOIS|Mohamed FARHAT

Ever since rockets started falling over the disputed region of Nagorno-Karabakh, a team of historians has worked to bring hundreds of ancient Armenian manuscripts to safety for fear they might be destroyed by artillery or vandalism.

Behind a thick vault door at the Matenadaran-Gandzasar cultural centre in Armenia’s capital Yerevan, troves of Armenian manuscripts – some dating as far back as the 13th century – can be found. They have been moved there from their sister complex in the disputed region of Nagorno-Karabakh as Armenia’s reignited conflict with Azerbaijan threatens their existence.

“We saw the rocket fire fall on the Gandzasar cathedral in Shusha, since the Matendaran is located next to the monastery complex of Gandzasar. For reasons of security, we decided to temporarily move everything to the Matendaran in Yerevan,” explains Aram Torosyam, director of the centre.

But he is not just worried about rocket fire. “The manuscripts were removed, given how the destruction of monuments is an ongoing phenomenon for these terrorists – Azerbaijani, Turkish groups, they have this tendency to destroy monuments.”

The manuscripts are an important part of Armenia’s cultural heritage, many documenting its deep and often troubled relationship with its neighbours.
Burkina Faso: Thousands of internally displaced face disenfranchisement from presidential vote

Thousands of people in Burkina Faso remain internally displaced after having fled the unrest that prevails in some regions of the country. These Burkinabes are now at risk of being disenfranchised in the November 22 presidential election, in which national security is likely to be a primary issue.

Thousands of Burkinabes have fled villages targeted by terrorist attacks, often leaving behind their papers and other important belongings.

The independent electoral commission has admitted that nationwide voting will not be able to take place due to the tenuous security situation, with the residents of nearly 1,600 villages unable to be registered.

About a third of Burkina Faso citizens face being excluded from the vote, one civil society activist told FRANCE 24.

Click on the video player to watch the full FRANCE 24 report

French security law: government crackdown on filming the police causes outrage

2020-11-17 14:44 

 

French bill banning images of police worries activists and journalists

Issued on: 17/11/2020 -
French Interior Minister Gérald Darmanin has said the controversial clause in the new bill is needed to “protect those who protect us”. © Thomas Coex, AFP / file picture

Text by:FRANCE 24

French lawmakers will begin debating a controversial bill on Tuesday that proposes a ban on the publication of images showing law enforcement officers. The bill has drawn sharp criticism from media outlets and activist groups who say it would violate principles of press freedom and the public’s right to be informed.

The bill's Article 24, which has been dubbed the “guerre des images” (war of images) in France, is aimed at “protecting those who protect us” by banning anyone – journalists and civilians alike – from publishing or broadcasting images in which on-duty police officers or gendarmes can be clearly identified for what the bill calls "malicious purposes".

The clause was first proposed by an MP for President Emmanuel Macron’s La République En Marche (LREM) party after police unions lobbied for it. The purpose of the bill "is to forbid any calls for violence or reprisals against officers and their families" in videos on social media, another LREM MP, Alice Thourot, told France Inter radio.

Critics, however, say the ban would essentially censor journalists by outlawing an activity that could be essential to their work. Images documenting police brutality or misconduct could also fall under the rubric of the ban. 

The January death of Cédric Chouviat, a delivery driver in Paris who suffered a heart attack and died after police put him in a chokehold, shined a spotlight on France's own demons. In the wake of George Floyd protests in the United States, France faced unprecedented protests against police brutality and racism over the summer. 

According to international NGO Reporters Without Borders (Reporters sans frontières or RSF), the clause “clearly violates the principles of press freedom and the public’s right to be informed”.

Read more: As George Floyd protests spread, France confronts its own demons

Civilians would also be prevented from sharing such images on social media. A Change.org petition protesting the ban had on Tuesday garnered more than 80,000 signatures.

Should the proposal – which will require approval from both France’s upper and lower houses – go through, offenders would face up to one year in prison and a €45,000 fine.

(FRANCE 24 with AFP)

French MPs tackle controversial clampdown on filming police

Issued on: 17/11/2020 - 
French police have long been accused of using heavy-handed tactics. A protestor in lawyer's garb holds a sign reading "Police, who will protect us when you misbehave ?" during a rally against the comprehensive security bill debated in parliament. 

STEPHANE DE SAKUTIN AFP

Paris (AFP)

The publication of police officers' faces unless blurred could become illegal in France, under legislation debated in parliament Tuesday and which critics say risks discouraging attempts to document abuses of authority.

France's security forces have long faced accusations of using brutal tactics when dealing with protesters, but also when confronting or arresting individuals, in particular from black or Arab minorities.

A series of incidents caught on video and spread on social media have spurred calls for reform, which gained momentum this year with the "Black Lives Matter" movement in the US following the death of George Floyd.

But police say they are increasingly under personal threat as they struggle to carry out President Emmanuel Macron's promise to reduce crime and insecurity, especially in the rough housing blocks surrounding Paris and other cities.

An attack on a police station outside Paris last month, by dozens of people armed with fireworks and steel bars, galvanised the government to vow concrete measures to protect officers and improve working conditions.

A new "comprehensive security" law from Macron's centrist government proposes reforms such as giving more autonomy to local police -- and potentially arming more of them -- and expanding the use of surveillance drones in high-crime areas.

But last month, his rightwing Interior Minister Gerald Darmanin supported a measure long sought by police unions, making it a crime to show images of an officer's face unless it has been made blurry.

Publication on social media or elsewhere with the intent of undermining an officer's "physical or psychological integrity" could be punished by a year in prison or fines of up to 45,000 euros ($53,000).

- 'War of images' -

Darmanin says the measure would "protect those who are protecting us," especially in poor neighbourhoods where tensions often run high between law enforcement and immigrant communities.

The law's co-author Jean-Michel Fauvergue, a former head of France's elite RAID police unit, rejected claims that police were getting new protections from criticism.

"In no way does this stop journalists from working," Fauvergue said at a press conference Tuesday.

He said the law would only punish publication of an officer's face "with messages calling for hate or violence".

Journalists and rights activists are not convinced, saying the stricter rules would effectively work as a "gag law," similar to a measure in force in Spain since 2015, that would hinder attempts to hold police accountable.

An open letter this month signed by journalists across France, including some from Agence France-Presse, urged lawmakers to reject the new image limits, and protests have been called for outside parliament on Tuesday.

"There's reason to fear that officers who already often try to prevent filming or photographs of their interventions in public areas, including through the use of force -- despite it being perfectly legal -- will feel even more empowered to do so," they wrote.

A letter from The UN Human Rights Council this month also warned French authorities the proposal "could discourage, even punish those who could supply elements of potential human rights violations by law enforcement, and provide a sort of immunity."

Critics point in particular to the hundreds of violence complaints filed against officers during the "yellow vest" anti-government rallies that erupted in 2018, which saw fierce clashes between protesters and police that made headlines worldwide.

In July, three officers were charged with manslaughter over the death of a delivery man, Cedric Chouviat, who was filmed by bystanders as officers had him in a chokehold after his arrest for a traffic offence in Paris.

Chouviat said "I'm suffocating" seven times before his body went limp.

"Black Lives Matter" also fuelled mass protests this summer against alleged police violence in France, particularly over the 2016 death in custody of a 24-year-old black man, Adama Traore.

Medical experts have exonerated the officers who arrested Traore, but his family has contested the findings, saying he was a victim of choking.

France's human rights auditor has also warned of "considerable risks" from the new law, saying it "must not impede on freedom of the press, nor on freedom of information."

"The publication of images regarding police interventions are legitimate and necessary for a democracy to function," the Defenseur des Droits said.

© 2020 AFP


MEXIQUE
Police open fire on femicide protest in Mexico

AMLO IS A MACHO NEOLIBERAL 
Issued on: 11/11/2020 - 
  
Screengrab of one of the videos below. This was filmed during a protest against femicides in Cancún, Mexico on November 9. © Facebook

Text by:Chloé Lauvergnier
VIDEOS AT THE END

Several people were injured when police opened fire during a protest against femicide in Cancun, Mexico on November 9. People across the globe expressed shock and horror as news of the crackdown spread across social media.

The protest was called after three femicides in Quintana Roo: One woman was killed in the town of Jose Maria Morelos and two others in Cancun. Their bodies all showed signs of torture. The protesters, rallied by the Quintana Roo Feminist Network, demanded justice for the victims and denounced violence against women in general.

This protest against femicides took place in Cancún on November 9.

"I saw police officers about 20 or 30 metres from me and then I started to hear shots being fired”

Nadia, a member of a group called DAS (which stands for Rights, Autonomy and Sexuality in Spanish) and Pride Cancun (Fierte Cancun) took part in the protest.

I went to the protest because I was really affected by these three femicides and because Mexico isn’t a safe place for women in general. Feminist organizations have been working with the authorities on these issues since the large protest held in Cancún on March 8 [Editor’s note: on International Women’s Day], but unfortunately, nothing is happening quickly.

We gathered around 5pm in front of the building of the Public Ministry, because that is the government body responsible for investigating femicides. Members of women’s rights organizations were there as well as the family members of Alexis [Editor’s note: 20-year-old Alexis was one of the women killed in Cancún that weekend] and her friends and teachers. There were a lot of teenagers who attended. I think that there were about 600 of us in total [Editor’s note: the media reported around 2,000 people]. Some carried photos of the victims. There were speeches. We stayed there for about two hours.

Nadia filmed this video showing people gathered in front of the Public Ministry in Cancún on November 9.


Nadia took these photos during the rally against femicides in Cancún on November 9.

Some people wanted to go to City Hall. But en route, certain people started destroying traffic signs. By the time we got there, I think there were only about a hundred of us left. We were yelling “Justice for Alexis!” but then some people started damaging City Hall, breaking windows and throwing rocks. Some people even went into the building and came out carrying things.

Nadio filmed this video in front of City Hall in Cancún on November 9. You can hear women calling out for justice for Alexis and the sound of windows breaking.

That’s when a group of police descended on us. I saw them about 20 or 30 metres away from me and then I heard shots being fired. I started running, along with everyone else, to hide in a nearby park. I don’t know if they were firing real bullets or rubber bullets but, later, real bullets were found at the site. The police beat some people and carried out numerous arrests. It’s the first time I’ve seen this kind of crackdown on a protest in Cancún. We are wondering who gave the order for the police to act in that way.

Nadia sent our team this video. It was filmed by someone who was near her when the police opened fire in front of Cancún City Hall on November 9.

This video, filmed in front of Cancún’s City Hall on November 9, shows police violently cracking down on protesters, starting at 0’30. The man filming the video yells out, “I’m here with them! Calm down, those are my students!” At 2’05, he says to a police officer: "Are you aware that you are firing bullets during a peaceful protest?” You can hear shots being fired during most of the video.

⚠️Vean una de las arbitrarias detenciones por las que no responden @CarlosJoaquin, @MaraLezama ni @kpya.
La policía que se mandó solita en Cancún, flanqueada por la gloriosa Guardia Nacional.
¿Qué carajos con este país?
🎥: Guadalupe Villarreal pic.twitter.com/Fm54CnXnWS Alfredo Lecona (@AlfredoLecona) November 10, 2020

Police officers violently push a protester during a demonstration in Cancún on November 9.

At least four people were wounded during the demonstration, according to the Mexican media. Two journalists were shot – one in the shoulder and another in the leg.


Cancún’s Director of Public Security removed from his post

No local officials have yet taken responsibility for what happened. The governor of Quintana Roo, Carlos Joaquín Gonzalez, said he gave "precise instructions" that there should be "no physical violence and no weapons during the protests on this day". The secretary of Public Security in Quintana Roo, Alberto Capella, said he had called for an “internal investigation”. The mayor of Cancun, Mara Lezama, also claimed that she had "given specific instructions for investigations to be opened [into the incident]".

She also demanded that the city’s Director of Public Security, Eduardo Santamaría, "be removed immediately from his post".

Numerous human rights organisations, including the office of the UN High Commissioner for Human Rights in Mexico, Amnesty International and Human Rights Watch, condemned "the excessive use of force” and “lethal weapons” during the protest.

Last year, a total of 34,608 intentional homicides and 1,012 femicides – cases where a woman or girl was killed by someone, usually a man because of her gender – were reported in Mexico, according to official statistics. The figures represent
s the highest number of femicides since officials began collecting data on these crimes.

Ethnic minorities face rising disparity in homicide risk across England and Wales

UNIVERSITY OF CAMBRIDGE

Research News

New research analysing racial disparities among murder victims across most of Britain over the last two decades shows that people of Asian ethnicity are on average twice as likely as White British people to be killed.

For Black people, however, the risk of homicide has been over five and a half times (5.6) higher than for White British people - on average - during the current century, and this disparity has been on the rise since 2015.

Researchers from the University of Cambridge's Institute of Criminology were surprised to find that official UK data did not include relative risk statistics by ethnicity, as is common in countries such as the US and Australia.

They argue that the UK's Office for National Statistics (ONS) should publish "relevant denominators with raw numerators" to help with public understanding of crime risk and police resourcing. The work is published as a research note in the Cambridge Journal of Evidence-Based Policing.

"Through a series of straightforward calculations, we found substantial racial inequality in the risks of being murdered in England and Wales," said co-author Professor Lawrence Sherman of the University of Cambridge's Institute of Criminology.

"The pandemic has given the public a crash course in statistics. It provides an opportunity to present all kinds of data in ways that have more meaning for the population as well as those on the front line of prevention," Sherman said.

Billy Gazard, a crime statistician for the ONS, said: "We have outlined our plans for improving crime statistics for England and Wales in our July 2020 progress update. Within this update we committed to better addressing inequalities in victimisation and highlighting those groups in society that are at most risk of experiencing crime. We plan to carry out further analysis over the coming year, which will include looking at homicide victimisation rates by ethnicity."

Cambridge criminologists went back over the last 20 years of annual figures using an approach now familiar to many through coronavirus statistics: rates of cases per 100,000 people. This provided a risk ratio for homicide rates by ethnicity in England and Wales.

The researchers say that, to the best of their knowledge, theirs is the first comparison of ethnic group trends in UK homicide victimisation rates per 100,000 to be published in recent decades, if ever.

They found that homicide risk for White and Asian people has stayed relatively consistent since the turn of the millennium - around one in 100,000 for White people and a little over two in 100,000 for Asian people, consisting primarily of persons of South Asian descent. For Black people, however, risks have fluctuated dramatically over the last 20 years.

The homicide victimisation rate for Black people was highest in the early noughties: almost 10 in 100,000 in 2001. It dropped by 69% between 2001 and 2012 to a low of 3 in 100,000 around 2013. Rates then began to climb again, rising seven times faster than for White people to reach over 5 in 100,000 last year.

When accounting for age, the disparity is starker still: for those aged 16 to 24, the 21st century average puts young Black people over ten and a half times (10.6) more likely than White people to be victims of homicide in England and Wales.

In fact, researchers point out that - per 100,000 people - the most recent data from 2018-19 puts the murder risk of young Black people 24 times higher than that of young White people.

The criminologists found no correlation between changes in homicide risk for different ethnicities. As an example, they point to the last three years of data: the homicide rate for White people aged between 16-24 dropped by 57%, while for young Black people it increased by 31%.

"Policing requires reliable evidence, and changing levels of risk are a vital part of preventative policing," said Sherman. "Our initial findings reveal risk inequalities at a national level, but they may be far greater or lower in local areas. We would encourage police forces to produce their own calculations of murder rates per 100,000."

Sherman has long advocated for a more "meaningful" approach to crime data. He has led on the development of the Cambridge Crime Harm Index: a classification system weighted by the impact of an offence on victims, rather than just counting crime numbers.

"Simple statistics show us that the risks of becoming a murder victim are far from equal," added Sherman. "We need more data analysis of this nature to inform police resource allocation, and promote a more fact-informed dialogue with communities across the country."

Exercised over nothing: Masks don't impair lung function during physical activity

While they might feel uncomfortable, researchers report facemasks do not significantly change the actual work of breathing or the flow of oxygen and carbon dioxide when worn while exercising

UNIVERSITY OF CALIFORNIA - SAN DIEGO

Research News

Wearing a facemask helps limit the spread of COVID-19 by reducing respiratory droplets and aerosols spewed into the air when people breathe, talk, laugh, sneeze or cough. But the physical barrier created by masks has prompted concerns that they might impair the cardiopulmonary system by making it harder to breathe, by altering the flow of inhaled oxygen and exhaled carbon dioxide and by increasing dyspnea -- a medical term that describe shortness of breath or difficulty breathing, especially during physical activity.

In a new study, published November 16, 2020 in the Annals of the American Thoracic Society, a team of American and Canadian researchers concluded that while sensations of dyspnea might increase, there is little empirical evidence that wearing a facemask significantly diminishes lung function, even when worn during heavy exercise.

"There might be a perceived greater effort with activity, but the effects of wearing a mask on the work of breathing, on gases like oxygen and CO2 in blood or other physiological parameters are small, often too small to be detected," said the study's first author Susan Hopkins, MD, PhD, professor of medicine and radiology at University of California San Diego School of Medicine.

"There's also no evidence to support any differences by sex or age in physiological responses to exercise while wearing a facemask," added Hopkins, who specializes in exercise physiology and the study of lungs under stress.

The single exception, the authors note, may be persons with severe cardiopulmonary disease in which any added resistance to breathing or minor changes in blood gases could prompt dyspnea great enough to affect exercise capacity.

"In such cases, these individuals might feel too uncomfortable to exercise, and that should be discussed with their doctor," Hopkins said. "However, the fact that these individuals are at great risk should they contract COVID-19 must also be considered"

The researchers came to their conclusions following a review of all known scientific literature published that examined the effects of various facemasks and respiratory loading devices on physiological and perceptual responses to physical activity. These studies assessed multiple factors, such as work of breathing (the quantified energy expended to inhale and exhale), arterial blood gases, effects on muscle blood flow and fatigue, cardiac function and flow of blood to the brain.

For healthy persons, the effects of wearing a mask on these physiological markers were minimal, no matter what type of mask was worn or the degree of exercise. The authors also said age played no significant influencing role among adults. Gender differences were deemed inconsequential.

"Wearing a facemask can be uncomfortable," said Hopkins. "There can be tiny increases in breathing resistance. You may re-inhale warmer, slightly enriched CO2 air. And if you're exercising, the mask can cause your face to become hot and sweaty.

"But these are sensory perceptions. They do not impact cardiopulmonary function in healthy people. So while dyspnea might be increased with a mask, you have to weigh that against the reduced risk of contracting COVID-19, knowing that the physiology is essentially unchanged."

###

Co-authors include: Paolo B. Dominelli, University of Waterloo, Ontario, Canada; Christopher K. Davis, UC San Diego and Rady Children's Hospital-San Diego; Jordan Guenette and William Sheel, University of British Columbia; Andrew M. Luks and Erik R. Swenson, University of Washington; Yannick Molgat-Seon, University of Winnipeg, Manitoba, Canada; Rui Carlos Sá, UC San Diego; and Michael K. Stickland, University of Alberta, Edmonton, Canada.

Field research has changed, and so should ethical guidelines, Brown professor says

BROWN UNIVERSITY

Research News

PROVIDENCE, R.I. [Brown University] -- The old ethics rules are no longer offering adequate protection to field research subjects, according to two leading social scientists from Brown and Pennsylvania State Universities -- and as a result, individual people and even entire societies are being left vulnerable to financial ruin, emotional manipulation and more.

In a peer-reviewed essay, Rose McDermott, a professor of international relations at Brown, and Peter K. Hatemi, a professor of political science at Pennsylvania State, argue that the advent of computers, the internet and social media have yielded massive change in the design and execution of certain types of large field experiments -- change that traditional ethics guidelines couldn't have anticipated.

Equipped with no widespread formal guidelines on securing voluntary consent in the internet age, scientists are designing big experiments that can, and often do, cause harm, McDermott and Hatemi say. But if research institutions, leading journals and scientific professional organizations were to publish and enforce updated ethical standards, scientists might better understand how to gather important insights without unintentionally damaging people and societies.

"The concern we're voicing is that early ethical guidance doesn't account for field experiments on huge numbers of people, because these experiments weren't common or even possible before the 1990s," McDermott said. "There's evidence that some of these recent experiments have stoked racial resentment, changed election outcomes and caused huge societal divisions. We're not saying these kinds of big field experiments aren't valuable -- we're saying we need to come up with ways to do it ethically."

McDermott's and Hatemi's essay was published as a "Perspective" piece on Monday, Nov. 15 in the journal Proceedings of the National Academy of Sciences. Perspective pieces undergo the same submission and review processes as research reports, but rather than describing the results of original research, they present a balanced, objective and thoroughly researched viewpoint on a specific field.

McDermott said that when today's scientists design experiments, they most often refer to ethical guidelines written decades ago, such as the Declaration of Helsinki -- a much-revised medical ethics guide first written in 1964 -- and the 1979 report "Ethical Principles and Guidelines for the Protection of Human Subjects of Research," now commonly known as the Belmont Report. But those guidelines, she said, were not created with computers, the internet and social media in mind.

"You've had a rise in the ability to do massive computing projects and analyze lots of data very quickly," McDermott said. "With social media platforms, you can have all kinds of access to huge populations. Combine with that the immense pressure on academics to publish high-impact research quickly and frequently, and you've got a world that looks very different than it did when the Belmont Report was published."

As a result, McDermott said, researchers have recently undertaken studies that made important discoveries but also changed people's behaviors, caused them trauma or even financially endangered them.

For example, several studies that have sought to identify what increases or depresses voter turnout have unintentionally altered election outcomes by influencing voters with racially-charged mailers and phone calls and door-to-door visits from fake political candidates. Scientists seeking to understand how social media alters people's moods and political affiliations have inadvertently engaged in the emotional manipulation of hundreds of thousands of people by pushing certain types of posts to their feeds. And many studies investigating the benefits and drawbacks of financial assistance have purposely given or withheld money from research subjects, causing them to become homeless or suffer from increased domestic violence.

"Science is a process of trial and error, and I think in the early days of large field experiments, people couldn't anticipate what might happen to the subjects," McDermott said. "But now we do know what can happen if we're not careful. We need to stop, take a breath and take stock of the damage some of these experiments have done so that we can learn from those mistakes and implement changes."

Those changes, McDermott and Hatemi argue, must come primarily from the top down. In their essay, the two scholars called on academic professional associations, journals and research institutions to update their policies to not only adhere to existing ethical norms but also formulate new requirements to address potential harm in large-scale field experiments that impact entire populations.

McDermott said she hopes the PNAS essay helps spur the kind of systemic change Henry Knowles Beecher kickstarted with his famous 1966 essay exposing unethical practices in the field of medical experimentation. Beecher's investigation eventually led to the passage of federal rules requiring scientists to obtain informed consent from study participants.

"While we would be happy to see individual scholars and individual universities addressing issues of informed consent in their field research, real change can only happen if it's systemic," McDermott said. "It's just like reversing climate change: Yes, it's good that you bought a Prius, but really what we need is for governments to shut down coal-fired plants. All of the institutions that hold power in science need to work in concert."

###

New study could help predict which individuals are more susceptible to cancer-causing agent

UNIVERSITY OF BIRMINGHAM

Research News

New insights into the mechanisms behind how cancer-causing agents in the environment activate genetic recombination in DNA could help to explain some of the effects of exposure as well as predicting which individuals may be more susceptible to developing the disease, a new UK study has suggested.

Everyone is exposed to low levels of carcinogens (substances or radiation that promote the formation of cancer) in the environment. One of the most widely found is benzopyrene - a general chemical pollutant found in smoke from stoves such as wood burners, exhaust fumes and barbequed meat and fish. One active ingredient of benzopyrene, BPDE, directly damages the DNA sequence forming what is known as adducts which in turn promote cancer-causing mutations.

While models exist showing how BPDE causes these mutations, some of the pathways are still not understood. It is currently believed that a BPDE adducts cause mutations during DNA synthesis because they activate a process called translesion synthesis - where cells copy the DNA despite the presence of unrepaired damage to allow progression of the replication fork - and this induces mutations. However, evidence also suggests the involvement of another process called homologous recombination (HR) which works by copying other undamaged parts of the genome. HR proteins repair complex DNA damage such as breaks in the DNA strands and interstrand cross-links, and protect and recover stalled or broken replication forks.

This latest study treated human cell lines with BPDE before using molecular biology methods, such as microscopy, to characterise the homologous recombination pathway in detail. Results have offered new insights showing that HR proceeds by an unusual mechanism at BPDE adducts and the process can be activated even when there are no stalled or collapsed replication forks. Instead, it is activated at single-stranded gaps in the DNA that are generated by the re-priming activity of PrimPol - a protein encoded by the PRIMPOL gene in humans.

The findings also address longstanding questions by showing that at bulky DNA adducts, the exchanges between the sister chromatids (the identical copies formed by the DNA replication of a chromosome), products of HR that have been traditionally connected with replication fork collapse and DSB repair, are associated with the repair of post-replicative gaps. Furthermore, these post-replicative gaps are produced by PrimPol, shedding light on the function of PrimPol during DNA damage tolerance.

Corresponding author Dr Eva Petermann from the University of Birmingham's Institute of Cancer and Genomic Sciences, says: "Our study has revealed new insights into the effects of benzopyrene exposure in cells, which is important for understanding environmental causes of cancer and cancer development in general. Understanding this mechanism could help to better predict and detect negative effects of pollution as well as allowing for better interpretation of cancer genomics. For example, genetic variants in the HR genes BRCA2 and RAD52 have been liked to lung cancer susceptibility meaning that understanding how HR helps cell deal with benzopyrene could help us to predict individuals who may be more susceptible to the disease

"Moving forwards it will be important to investigate the impact of such genetic variants on HR at ssDNA gaps. A PRIMPOL variant has also been suggested to play a potential role in cancer. It could also help predict which individuals will be more sensitive to carcinogen exposure."

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The paper 'PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts' was published today (17 November) in Nature Communications.r