Showing posts sorted by date for query SMOKING. Sort by relevance Show all posts
Showing posts sorted by date for query SMOKING. Sort by relevance Show all posts

Monday, June 10, 2024

New pathways for treating never-smoker lung cancer revealed


Precision medicine characterization through integration of genomic, transcriptomic, proteomic, and clinical data



NATIONAL RESEARCH COUNCIL OF SCIENCE & TECHNOLOGY

Overview of Genomic and Proteomic Analysis in Never-Smoking Lung Cancer Patients 

IMAGE: 

(LEFT) DISTRIBUTION OF GENDER AMONG NEVER-SMOKING LUNG CANCER PATIENTS ANALYZED IN THIS STUDY WITH PREDOMINANCE OF FEMALES.
(MIDDLE) SCREENING RESULTS FOR GENETIC MUTATIONS IN NEVER-SMOKING LUNG CANCER PATIENTS, SHOWING 15% OF PATIENTS WITH UNIDENTIFIED MUTATIONS IN LUNG TISSUE. A TOTAL OF 101 TISSUE SAMPLES UNDERWENT GENOMIC AND PROTEOMIC ANALYSIS.
(RIGHT) MOLECULAR CHARACTERIZATION OF KOREAN NEVER-SMOKING LUNG ADENOCARCINOMA USING MULTI-OMICS ANALYSIS.

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CREDIT: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY(KIST)




The primary cause of lung cancer is smoking. However, the incidence of lung cancer among never-smokers has been steadily increasing, especially among women. While approximately 80% of never-smoking lung cancer patients are prescribed targeted therapies that focus on mutations in proteins such as EGFR and ALK, the remaining patients often receive cytotoxic chemotherapy with high side effects and relatively low response rates, highlighting the urgent need for targeted therapies.

Dr. Lee Cheolju's team at the Chemical Life Convergence Research Center at the Korea Institute of Science and Technology (KIST), along with Dr. Kim Seon-Young's team at the Korea Research Institute of Bioscience and Biotechnology and Dr. Han Ji-Youn's team at the National Cancer Center, have elucidated the overexpression of estrogen signaling pathways in specific Korean never-smoking lung cancer cases using multi-omics analysis and proposed the anti-cancer drug saracatinib as a targeted therapeutic agent. Multi-omics integrates various molecular information, with proteomics presenting a particular challenge due to the need to analyze small amounts of proteins without loss, typically microgram-scale.

The research team obtained tissue samples from 101 Korean never-smoking lung cancer patients without identified treatment targets among 1,597 patients who visited the National Cancer Center over the past decade and distributed clinical information, genomic, transcriptomic, proteomic, and phosphoproteomic data to each omics analysis method for mutual referencing. Particularly, proteomic analysis measured an average of over 9,000 proteins and 5,000 phosphorylated proteins per sample using only 100 μg of protein, which is 10% of the amount required for conventional protein analysis, using isotopic labeling techniques.

Analysis of genetic mutations and cellular signaling pathways revealed that driver mutations of genes known to be associated with cancer, such as STK11 and ERBB2, were observed in the tissues of never-smoking lung cancer patients. Additionally, while the estrogen signaling pathway was found to be overexpressed, there were no significant changes in estrogen hormone receptors. Based on this, saracatinib, a sub estrogen signaling transduction protein inhibitor, showed statistically significant (p<0.01) cell death effects when applied to cells with mutations in STK11 and ERBB2 compared to the control group without such mutations.

Building on this, the research team is developing a molecular diagnostic technique for discriminating patients with specific expression of estrogen signaling pathways among never-smoking lung cancer patients. Additionally, they plan to conduct preclinical trials of saracatinib's therapeutic effects on never-smoking lung cancer animal models in collaboration with the National Cancer Center.

Dr. Lee Cheolju of KIST stated, "This successful case of discovering new therapeutic targets for refractory cancer through multi-omics analysis is based on purely domestic research and the collaborative efforts of hospitals and research institutions, which holds significant meaning. Building on this experience, we will lead the expansion of multi-omics research on human diseases."


Representative Features and Identification of Mutant Genes in Patients with Unidentified Mutations 

KIST was established in 1966 as the first government-funded research institute in Korea. KIST now strives to solve national and social challenges and secure growth engines through leading and innovative research. For more information, please visit KIST’s website at https://eng.kist.re.kr/

This research was supported by the Ministry of Science and ICT, Korea, under the KIST's main projects and the Bio-Medical Technology Development Program (2022M3H9A2096187). The research results have been published online in the latest issue of the international journal Cancer Research (IF 11.2, JCR field 10.6%).

 

Lung organoids unveil secret: How pathogens infect human lung tissue




UNIVERSITY OF BASEL

Pseudomonas aeruginosa 

IMAGE: 

THE PATHOGENIC BACTERIUM PSEUDOMONAS AERUGINOSA BREACHING THROUGH THE RESPIRATORY EPITHELIA OF A HUMAN LUNG MICROTISSUE MODEL, CAPTURED VIA SCANNING ELECTRON MICROSCOPY.

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CREDIT: BENOIT LAVENTIE, BIOZENTRUM, UNIVERSITY OF BASEL




How do pathogens invade the lungs? Using human lung microtissues, a team at the Biozentrum of the University of Basel has uncovered the strategy used by a dangerous pathogen. The bacterium targets specific lung cells and has developed a sophisticated strategy to break through the lungs’ line of defense.

Earlier this year, the WHO published a list of twelve of the world’s most dangerous bacterial pathogens that are resistant to multiple antibiotics and pose a grave threat to human health. This list includes Pseudomonas aeruginosa, a much-feared nosocomial pathogen that causes severe and life-threatening pneumonia. This pathogen is especially threatening to immunocompromised patients and those on mechanical ventilation, with mortality rates up to 50 percent.

The lung barrier is penetrable

Pseudomonas aeruginosa has developed a broad range of strategies to invade the lungs and the body. Researchers led by Prof. Urs Jenal at the Biozentrum, University of Basel, have now gained novel insights into the infection process using lab-grown lung microtissues generated from human stem cells. In the scientific journal “Nature Microbiology”, they describe how Pseudomonas breaches the top layer of lung tissue and invades deeper areas. This study was conducted as part of the National Center of Competence in Research (NCCR) “AntiResist”.

Our lungs are lined by a thin layer of tightly packed cells that protects the deeper layers of lung tissue. The surface is covered with mucus, which traps particles such as microorganisms and is removed from the airways by specialized cells. This layer serves as an effective almost impenetrable barrier against invading pathogens. However, Pseudomonas bacteria have found a way to breach it. But how the pathogen crosses the tissue barrier has remained a mystery until now.

Lung organoids provide new insight into infections in humans

“We have grown human lung microtissues that realistically mimic the infection process inside a patient’s body,” explains Jenal. “These lung models enabled us to uncover the pathogen’s infection strategy. It uses the mucus-producing goblet cells as Trojan horses to invade and cross the barrier tissue. By targeting the goblet cells, which make up only a small part of the lung mucosa, the bacteria can breach the defense line and open the gate.”

With a large arsenal of virulence factors, known as secretion systems, the pathogen specifically attacks and invades the goblet cells, replicates inside the cells and ultimately kills them. The burst of the dead cells leads to ruptures in the tissue layer, making the protective barrier leaky. The pathogens exploit this weak spot: They rapidly colonize the rupture sites and spread into deeper tissue regions.

New sensor for monitoring bacteria

Using human lung organoids, the scientists have been able to elucidate the sophisticated infection strategies of Pseudomonas. However, it remains unclear how the pathogens adapt their behavior during the infection process. For example, they must first be mobile to spread over the tissue surface, then quickly adhere to lung cells upon contact, and later activate their virulence factors. It is known that the bacteria can rapidly change their behavior thanks to small signaling molecules. Until now, however, the technology to study these correlations was not available.

Jenal’s team has now developed a biosensor to measure and track a small signaling molecule called c-di-GMP in individual bacteria. The method was recently described in Nature Communications. "This is a technological breakthrough," says Jenal. "Now we can monitor in real time and with high resolution how this signaling molecule is regulated during infection and how it controls the pathogen’s virulence. We now have a detailed view on when and where individual bacterial cells activate certain programs to regulate their behavior. This method enables us to investigate lung infections in more detail."

Organ models mimic conditions in patients

"Thanks to the development of human lung organoids, we now have a much better understanding of how the pathogens behave in human tissue and presumably in patients," emphasizes Jenal. "This brings us a big step closer to the goal of NCCR AntiResist." Organoids of the human lung and other organs like the bladder allow the researchers to study the effects of antibiotics in tissue, for example, identifying where and how bacteria survive during treatment. Such organ models will be indispensable in the future for developing new and effective strategies to combat pathogens.

Sunday, June 09, 2024


Why are tobacco firms targeting the poor?

By Dr. Tim Sandle
DIGITAL JOURNAL
Published June 7, 2024

Australia is about to introduce a raft of new restrictions on vaping - Copyright AFP Raul ARBOLEDA

Researchers have found that flavour restrictions affect tobacco buyers differently, depending on the socioeconomic status of the user. This differential suggests that tobacco firms are reaping greater profits by targetting those in lower socioeconomic groups. Consequently, the health impacts upon the working class are greater.

Restricting menthol flavour in cigarettes while making nicotine replacement therapy, such as a skin patch that can help ease withdrawal, more available and affordable has the potential to reduce socioeconomic disparities in tobacco use. This requires regulation in order to push tobacco companies to remove flavourings in their addictive products.
E-cigarette user blowing a cloud of aerosol (vapor). The activity is known as cloud-chasing. Image: micadew from US – Smoke Screen, CC 3.0

That was one of the key findings in a study published in an academic paper featured in the journal Nicotine and Tobacco Research. The illuminating study is titled “Selective Reduction of Socioeconomic Disparities in the Experimental Tobacco Marketplace: Effects of Cigarette and E-cigarette Flavor Restrictions.”

The study marks a new use of existing data, drawn from the Fralin Biomedical Research Institute at VTC’s Addiction Recovery Research Center.

For the study, the researchers analysed data from their Experimental Tobacco Marketplace to look beyond broad effects of tax and regulatory policies for the journal’s special issue on the health equity effects of restricting flavoured nicotine.
© Denis Charlet, AFP

Cigarette smoking is the leading cause of preventable death in the U.S., according to the U.S. Centers for Disease Control and Prevention. Smoking also accounts for more than 30 percent of the difference in life expectancy among socioeconomic groups, according to the study’s lead author, Assistant Professor Roberta Freitas-Lemos.

The tobacco industry has seemingly more heavily marketed flavoured tobacco products, such as menthol cigarettes, in communities with lower household incomes and educational attainment. This policy is contributing to increased adverse health outcomes in these communities and is creating a disparity in health outcomes based on social class.

Other factors leading to working class people being more likely to smoke are: reduced access to affordable smoking cessation, social factors such as greater tobacco use and reduced support for quitting among friends, and greater exposure to stress and adversity

Freitas-Lemos said the team saw an opportunity to use the marketplace to extend the Fralin Biomedical Research Institute’s work in addressing equity and inclusion in health research

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Vaping has become a new battleground between tobacco lobbyists and anti-smoking campaigners – Copyright AFP/File JOEL SAGET

Freitas-Lemos adds: “We realized we could use an existing data set, split the sample in two based on socioeconomic status, and compare how policies implemented affected purchase behaviours of different groups,” she said.

Furthermore, the academic states: “The study has shown us that flavour restrictions may decrease tobacco-related disease and death rates.”

The research also points to the need to evaluate tobacco restrictions in a broader context, as cigarette substitution is highly dependent on what other products are available.

Saturday, June 08, 2024

Britain’s Century Long Opium Trafficking and China’s Century of Humiliation (1839-1949)


For the Chinese, the trauma of the Century of Humiliation continues as a blunt reminder of their past defeat and neo-colonial servitude, as well as a reminder of the West’s self-righteous hypocrisy and arrogance.

In 1500, India and China were the world’s most advanced civilizations. Then came the Europeans. They eventually looted and wreaked havoc on both, just as they were to on the Americas and Africa. For India and China, Britain was the chief culprit, relying on state-sponsored drug-running backed by industrialized military power. The British Empire was the world’s largest producer and exporter of opium—the main product of global trade after the gradual decline of the slave trade from Africa. Their “civilization” brought the Century of Humiliation to China, which only ended with the popular revolution led by Mao Zedong. This historic trauma and the struggle to overcome it and re-establish their country is etched in the minds of the Chinese today.

Before the British brought their “culture,” 25% of the world trade originated in India. By the time they left it was less than 1%. British India’s opium dealing was for the large part of the 19th Century the second-most important source of revenue for colonial India. Their “opium industry was one of the largest enterprises on the subcontinent, producing a few thousand tons of the drug every year – a similar output to Afghanistan’s notorious opium industry [during the US occupation], which supplies the global market for heroin.” Opium accounted for about 17-20% of British India revenues.

In the early 1700s, China produced 35% of the world GDP. Until 1800 half the books in the world were printed in Chinese. The country considered itself self-sufficient, not seeking any products from other countries. Foreign countries bought Chinese tea, silk, and porcelain, having to pay in gold and silver. Consequently, the balance of trade was unfavorable to the British for almost two centuries, like the situation the US and Europe face with China today.

This trade slowly depleted Western reserves. Eventually, 30,865 tons of silver flowed into China, mostly from Britain. Britain turned to state sponsored drug smuggling as a solution, and by 1826 the smuggling from India had reversed the flow of silver. Thus began one of the longest and continuous international crimes of modern times, second to the African slave trade, under the supervision of the British crown.

(The just formed United States was already smuggling opium into China by 1784. The US first multi-millionaire John Jacob Astor grew rich dealing opium to China, as did FDR’s grandfather, Warren Delano, Jr.)

The British East India Company was key to this opium smuggling. Soon after Britain conquered Bengal in 1757, George III granted the East India Company a monopoly on producing and exporting Indian opium. Eventually its Opium Agency employed some 2500 clerks working in 100 offices around India.

Britain taxed away 50% of the value of Indian peasants’ food crops to push them out of agriculture into growing opium. This soon led to the Bengal famine of 1770, when ten million, a third of the Bengali population, starved to death. Britain took no action to aid them, as they did almost a century later with their orchestrated famine in Ireland. Another famine hit India in 1783, and again Britain did nothing as 11 million starved. Between 1760-1943, “As per British sources, more than 85 million Indians died in these famines which were in reality genocides done by the British Raj.”

At its peak in the mid-19th century, the British state-sponsored export of opium accounted for roughly 15% of total colonial revenue in India and 31% of India’s exports. The massive revenues from this drug money solidified India as a substantial financial base for England’s later world conquests.

In 1729, the Chinese emperor declared the import of opium illegal. At the time it amounted to 200 chests a year, each 135 pounds, a total of 14 tons. The emperor in 1799 reissued the prohibition in harsher terms, given imports had leaped to 4,500 chests (320 tons). Yet by 1830 it rose to 1100 tons, and by 1838, just before the British provoked the First Opium War (1839-1842), it climbed to 40,000 chests (2800 tons).

chest of opium cost only £2 to produce in India but it sold for £10 [over $1,000 in today’s prices] in China, nearly an £8 profit per chest.

About 40,000 chests supplied 2.1 million addicts in a Chinese population of 350 million. China was losing over 4000 tons of silver annually. Addicts were mostly men, twenty to fifty-five years old, which should have been their most productive years. Smoking opium gradually spread to different groups of people: government officials, merchants, intelligentsia, women, servants, soldiers, and monks.

Just before the First Opium War the Chinese “drug czar,” Lin Zexu, wrote to Queen Victoria, “Where is your conscience? I have heard that the smoking of opium is very strictly forbidden by your country; this is because the harm caused by opium is clearly understood. Since it is not permitted to do harm to your own country, then even less should you let it be passed on to the harm of other countries.” In standard imperialist arrogance, Britain ignored the letter and challenged the very legality of China’s sovereign decision to prohibit opium imports.

Britain provoked this First Opium War in retaliation for China seizing and destroying 1300 tons of opium held by British drug dealers off Canton (now Guangzhou). This had a value equal to one-sixth of the British empire’s military budget. British Foreign Secretary Palmerston demanded an apology, compensation for the opium, a treaty to prevent Chinese action against British drug-running, and opening additional ports to “foreign trade,” their euphemism for drug dealing.

The British India Gazette reported on the sack of one Chinese city during the war:

A more complete pillage could not be conceived than took place. Every house was broken open, every drawer and box ransacked, the streets strewn with fragments of furniture, pictures, tables, chairs, grain of all sorts — the whole set off by the dead or the living bodies of those who had been unable to leave the city from the wounds received from our merciless guns… The plunder ceased only when there was nothing to take or destroy.

Once Britain defeated China, the Treaty of Nanking gave Hong Kong to the British, which quickly became the center of opium drug-dealing, soon providing the colony most of its revenue. The treaty also allowed the British to export unlimited amounts of opium.

In 1844, France and the US forced China to sign similar unequal and unjust treaties, with the same unrestricted trading rights.

In the wake of the First Opium War, a devastating famine hit southern China, causing mass starvation among millions of poor Chinese peasants. Soon the Taiping Rebellion against Chinese imperial rule broke out, claiming 20 million Chinese lives between 1850 and 1864. As with many later civil wars, as in Syria a decade ago, the European states financed the rebels to undermine the national government.

Karl Marx detailed how Britain provoked the Second Opium War (1856-1860). France joined in the looting. The Times of London, propagandists for their state-sponsored drug mafia, declared, “England, with France . . . shall teach such a lesson to these perfidious hordes that the name of Europe will hereafter be a passport of fear, if it cannot be of love, throughout their land.”

In October 1860 the British and French military attacked Beijing. Despite French protests, British commander Lord Elgin destroyed Yuanming Yuan, the emperor’s summer palace, in a show of contempt for the Chinese.

The Summer Palace was the quintessential treasure house of China. No such collection of wealth and beauty had ever existed anywhere on earth. Nor would it ever again.…in some 200 fabulously decorated buildings, thirty of them imperial residences, lay riches beyond all dreams of avarice. Jewels, jade, ceremonial robes, the court treasures, bales of silk, and countless priceless artifacts represented the years of accumulated tribute placed before the Chinese emperors. There were splendid galleries of paintings and irreplaceable libraries…For three days British and French troops rampaged through the palace’s marble corridors and glittering apartments, smashing with clubs and rifle butts what they were unable to carry away.

When the robbery and destruction was finished, they burned Yuanming Yuan to the ground. An estimated 1.5 million Chinese relics were taken away, many still filling museums and the homes of the wealthy in the West today.

Britain and France forced China to legalize the import of opium, which reached 5000 tons by 1858, an amount surpassing global opium production in 1995. China had to agree that no Westerner could be tried in Chinese courts for crimes committed in the country, and, ironically, to legalize Christian missionary work.

The 1881 pamphlet, Opium: England’s Coercive Policy and Its Disastrous Results in China and India, stated:

As a specimen of how both wars were carried on, we quote the following from an English writer on the bombardment of Canton: ‘Field pieces loaded with grape were planted at the end of long, narrow streets crowded with innocent men, women and children, to mow them down like grass till the gutters flowed with their blood.’ In one scene of carnage, the Times correspondent recorded that half an army of 10,000 men were in ten minutes destroyed by the sword, or forced into the broad river. The Morning Herald asserted that ‘a more horrible or revolting crime than this bombardment of Canton has never been committed in the worst ages of barbaric darkness.’

By the mid-1860s, Britain was in control of seven eighths of the vastly expanded opium trade into China. Opium imports from India skyrocketed to 150,000 chests (10,700 tons) in 1880. British opium earnings amounted to $2 billion a year in today’s money and accounted for nearly 15% of the British Exchequer’s tax revenue. The London Times (October 22, 1880) outrageously claimed that “the Chinese government admitted opium as a legal article of import, not under constraint, but of their own free will.” Lord Curzon, later Under Secretary for India, “denied that England had ever forced opium upon China; no historian of any repute, and no diplomatist who knew anything of the matter, would support the proposition that England coerced China in this respect.”

China began domestic production to curtail losing more silver to imported opium. After 1858, large tracts of land were given over to opium production, and provinces turned from growing food and other necessities to opium. Eventually the Chinese were producing 35,000 tons, about 85% of the world’s supply, with 15 million addicts consuming 43,000 tons annually.

China, now greatly weakened by the British narco state, surrendered territory to Russia equal to the combined size of France, Germany, and Spain. In 1885 France seized Chinese Southeast Asia. In 1895, Japan seized Taiwan and Chinese-controlled Korea.

The Eight-Nation Alliance (Japan, Russia, Britain, France, the United States, Germany, Italy, and Austria-Hungary) invaded again in 1900 to crush the nationalist Boxer Rebellion. An indemnity of 20,000 tons of silver was extracted, and China reduced to a neo-colony.

By 1906, besides British India, opium dealing also provided 16% of taxes for French Indochina, 16% for the Netherlands Indies, 20% for Siam, and 53% for British Malaya.

That year, the British, still exporting 3500 tons to China, finally agreed to end the dirty business within ten years. The British crown had the distinction of being the biggest opium smuggler in history – a central factor in their wrecking Chinese and Indian civilizations.

World opium production by 1995 was down to 4,200 metric tons (4,630 tons), mostly from Burma and Afghanistan. The Taliban banned it in 2000, and production fell from 3400 to only 204 tons. The 2001 US invasion of Afghanistan reversed this, and by 2008, US occupied Afghanistan was producing 90% of the world’s opium, reaching 10,000 tons in 2017. After the US was driven out in 2021, the Taliban quickly stopped opium production. The United States Institute of Peace, possibly revealing US support for narco-trafficking, pronounced, “the Taliban’s successful opium ban is bad for Afghans and the world” and “will have negative economic and humanitarian consequences.”

The blight of opium on China was not resolved until the revolutionary victory in 1949 – though it continued in British Hong Kong. Mao proclaimed “China has stood up,” ending its Century of Humiliation during which at least 100 million Chinese were killed in wars and famines, with up to 35 million during the Japanese invasion from 1931-1945.

By 1949, China had been reduced to one of the world’s poorest countries. Just 75 years ago four out of five Chinese could not read or write. But since 1981, China has lifted 853 million of its people out of poverty, has become an upper middle income country according to the World Bank, and regained its stature in the world. The West now views China as a renewed threat, again seeking to economically disable it and chop it into pieces. However, this time, the Chinese people are much better prepared to combat imperialist designs to impose a new era of humiliation on them.


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Stansfield Smith, ChicagoALBASolidarity.com, stansfieldsmith100@gmail.com. Stan has been involved in anti-war organizing for 45 years, and has written a number of articles about Venezuela, Bolivia, Cuba, Nicaragua, as well as previous articles related to the subject here. They have appeared in Monthly Review online, Orinoco Tribune, Dissident Voice, Counterpunch, Popular Resistance, and others. Read other articles by Stansfield.

Sunday, June 02, 2024

How Prehistoric Humans Discovered Fire Making 


 

 MAY 31, 2024

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José Clemente Orozco’s fresco mural Prometeo del Pomona College (1930)

In ancient Greek myth tells the story of Prometheus, who, after molding humans out of clay and teaching them the fine arts of civilization, defied the Olympian Gods by stealing the secret of fire and offering it to humans. Prometheus paid dearly for this act of transgression that doted humankind with unprecedented technological know-how ultimately transforming their condition into one of great power.

The moral behind the Promethean archetype is a cautionary one, intended to warn us about the risks attached to the unbridled pursuit of technology that can inadvertently result in catastrophic scenarios. The Prometheus myth underscores not only the formidable power that individuals may come to possess by defying authority in the quest to develop science and technology but also suggests that anyone who does so will suffer the consequences.

It is significant that the Greeks chose fire as the subject to deliver this warning. Without a doubt, the capacity to produce and control fire stands out among the most transformative technological feats achieved by our prehistoric ancestors; one that ultimately consolidated human planetary domination. But how, when, and where did early humans harness the technologies necessary to master fire making? What does the archeological record tell us about how they finally obtained the Promethean secret of fire making?

Like other milestones marking the human evolutionary pathway (like perfecting stone axes or mastering advanced hunting practices), the know-how required to make, use, and control fire evolved progressively, encouraged by human ingenuity and, probably also, by trial and error. Fire making techniques were perfected over time and transmitted socially, while different human groups explored the multifaceted revolutionary potential offered by controlling it. Before truly mastering fire making, early humans may have experienced a precedent phase during which they used fire passively, gathering, preserving and even transporting brazes ignited by natural causes (lightning, spontaneous combustion, etc.), prior to learning how to actively generate and control it. In the meantime, curiosity led them to explore the mysterious properties of fire, while also inspiring them to seek ways to master its secrets.

While looking back in time, it is difficult to pinpoint exactly when our ancestors began to control fire-making technologies. Recognizing intentionally ignited and sustained fires in archeological contexts poses challenges since the simple presence of burned bones and stones or localized areas of charred soils are not sufficient to prove that hominins were actively producing fire. Before 1 million years ago, sparse evidence from some African sites could suggest that hominins were opportunistically harvesting fire from naturally kindled blazes; rather than practicing truly operative fire making. However, a multidisciplinary study from the Wonderwerk Cave in South Africa reports convincing evidence for intentional burning in a controlled archeological context dated to 1 million years old.

While such early signals of fire making are rare and difficult to recognize and interpret, globally, the ability to set fire at will is heralded as a major groundbreaking accomplishment attributed to the Homo erectus lineage who lived during the Lower Paleolithic period. This group of hominins is known to have produced an impressive array of tools belonging to the so-called Acheulian industrial complex that emerged in Africa 1.75 million years ago. Fire making is not the only groundbreaking achievement marking the 1.4 million-year-long reign of the Acheulian peoples. Throughout this time, hominins invented and came to master highly complex technological achievements, documented archeologically in the form of stone and (sometimes) bone tools. These technologies facilitated the expansion of H. erectus populations into Eurasia, where they continued to perfect and diversify the toolkits that afforded them adaptive advantages; improving their ability to multiply and flourish.

Aside from their broadening cultural repertoire, parallel processes of social development (more difficult to recognize in the archeological record) were also taking place. Rising demography is manifest in both Africa and Eurasia from the exponential increases in the number, density, and variety of archeological sites: a phenomenon that must in turn have generated more frequent interpopulational encounters, assuring reproductive viability and offering opportunities for cultural transmission at various levels. Acheulian hominins began to organize themselves into functional collective units that allowed them to more effectively share and exchange their newfound skills: a strategy that would ultimately favor their survival.

It is only after the 1-million-year mark that the global repercussions of the consolidation of fire-making technologies become more clearly visible in some archeological contexts outside of Africa. At the Acheulian site of Gesher Benot Ya’aqov, in the Jordan Valley, for example, compelling evidence some 780,000 years old confirms that hominins were not only making fire at willbut were also deliberately cooking fish. Meanwhile, as far away as China, but in a similar timeframe (800,000 to 600,000 years ago), there is proof in the famous multi-leveled Acheulian cave site of Zhoukoudian that individuals belonging to an Asian strain of H. erectus were also successfully experimenting with controlled burning in occupational settings.

Despite these rare and ancient occurrences, indications that hominins were actively generating and controlling fire became more ubiquitous only thousands of years later, toward the end of the Acheulian phase (after around 400,000 years ago), and then even more frequent as we move into the Eurasian Middle Paleolithic and African Middle Stone Age. Technological and behavioral diversity multiplies exponentially from this time forward, as toolkits differentiate to form complex formal manifestations of culture. Importantly, dwellings (often in caves) become recognizable provisioned home bases, where hominins returned regularly (or seasonally) over many generations. For the first time, organized living spaces can be identified within base camp settings that were structured around easily recognizable combustion structures, or hearths.

So, while H. erectus is credited with initiating the fire-making revolution sometime during the early phases of the Acheulian, it is only much later that the Pre-Neandertals and other forms of pre-modern and modern Homothriving in Eurasia at the end of this period began to more intensively experiment with the enormous potential offered by the Promethean gift of fire. Around 350,000 years ago, on the eve of the shift from the Lower to the Middle Paleolithic, the prevalence of hearths within prehistoric living spaces signals important changes taking place in hominin lifestyles.

Making fire was interwoven with many social, technological, and behavioral developments that triggered major changes that would shape humanity from that point onward. While (rather surprisingly) fire does not seem to have been a requirement for hominins expanding to territories situated in higher latitudes, it would have helped facilitate their capacity to take root in areas dominated by harsh or unstable climatic conditions. In terms of hunting, fire-wielding hominins would have had huge advantages over other kinds of carnivores with whom they competed for resources; fire also guaranteed the safety and protection of their own communities.

Besides taking advantage of these benefits, our ancestors experimented extensively with fire over thousands of years and grasped the significance of its power to transform the properties of other materials available in the landscape. They eventually learned to use fire to improve their weaponry (like heating flint to improve its knapping quality) and to assemble composite implements by hafting pointed stone tools onto branches using adhesives prepared with heat—such as tar and ocher. In addition, cooking food must radically have transformed the hominin diet, reducing the likelihood of contracting bacterial diseases and parasites from meat and other foodstuffs, while opening up innovative pathways toward enlarging the paleo diet (boiling, smoking, drying, etc.).

But among all of the spectacular changes afforded to prehistoric humans by the mastery of fire perhaps the most important and most difficult to assess archeologically is the social impact it must have had. With fire, humans were finally able to dompt the darkness and linger with confidence into the night, gathered together in proximity to hearths that afforded them warmth, light, and comfort. This leads us to postulate a variety of socially related activities, like storytelling or other communal rituals. While it is impossible to measure the impact of this complex series of events that so indelibly affected human evolution, we can still discern how technology and culture were interwoven to catalyze the advancement of symbolic communication within the developing brains of our ancestors, finally grouped into distinct territorial social units.

Later still, during the Middle and Upper Paleolithic periods, our human predecessors used firelight to venture into deep cave systems to perform ritual activities and create art on the cave walls, bringing it to life with the play of torchlight. Toward the end of the Paleolithic, humans continued to explore the powerful transformative qualities of fire, eventually learning to obtain and maintain the high temperatures necessary to transform clay into pottery and, later, to melt metal ores into usable items that would, once again, revolutionize the human story.

Even today, fire remains a powerful force whose symbolic meaning is deeply rooted within our collective unconsciousness. Though Prometheus was eventually delivered from his torment, his transgression still resonates as a lesson to humankind’s defiant striving to master transformative technologies without heeding the looming dangers posed by the unforeseen consequences of such actions.

This article was produced by Human Bridges.