Saturday, April 15, 2023

A rechargeable battery made from food

It is the first ever-made rechargeable edible battery; described on Advanced materials it may be applied in health diagnostics, food quality monitoring and edible soft robotics. It has been realized at Istituto Italiano di Tecnologia.


Peer-Reviewed Publication

ISTITUTO ITALIANO DI TECNOLOGIA - IIT

A rechargeable battery made from food 

IMAGE: A TEAM OF RESEARCHERS AT THE ISTITUTO ITALIANO DI TECNOLOGIA (IIT-ITALIAN INSTITUTE OF TECHNOLOGY) HAS CREATED A TOTALLY EDIBLE AND RECHARGEABLE BATTERY, STARTING FROM MATERIALS THAT ARE NORMALLY CONSUMED AS PART OF OUR DAILY DIET. THE PROOF-OF-CONCEPT BATTERY CELL HAS BEEN DESCRIBED IN A PAPER PUBLISHED IN THE ADVANCED MATERIALS JOURNAL. THE POSSIBLE APPLICATIONS ARE IN HEALTH DIAGNOSTICS, FOOD QUALITY MONITORING AND EDIBLE SOFT ROBOTICS. view more 

CREDIT: IIT-ISTITUTO ITALIANO DI TECNOLOGIA

Milan (Italy), 13th April 2023 – A team of researchers at the Istituto Italiano di Tecnologia (IIT-Italian Institute of Technology) has created a totally edible and rechargeable battery, starting from materials that are normally consumed as part of our daily diet. The proof-of-concept battery cell has been described in a paper, recently published in the Advanced Materials journal. The possible applications are in health diagnostics, food quality monitoring and edible soft robotics.

The study has been realized by the group of Mario Caironi, coordinator of the Printed and Molecular Electronics laboratory of the IIT Center in Milan (Italy); Caironi has been focusing on the study of the electronical properties of food and its by-products, in order to unite them with edible materials and create new edible electronic materials. In 2019, Caironi won a 2-million-euro ERC consolidator grant for the ELFO Project, which explores the edible electronics field.

Edible electronics is a recently growing field that could have a great impact on the diagnosis and treatment of gastrointestinal tract diseases, as well as on the food quality monitoring. One of the most interesting challenges in the development of future edible electronic systems is to realize edible power sources.

The IIT’s research group took inspiration from the biochemical redox reactions that happens in all the living beings, and developed a battery that utilizes riboflavin (vitamin B2, found for example in almonds) as anode and quercetin (a food supplement and ingredient, present in capers, among others) as cathode. Activated charcoal (a widespread over-the-counter medication) was used to increase electrical conductivity, while the electrolyte was water-based. The separator, needed in every battery to avoid short circuits, was made from nori seaweed, the kind found in sushi. Then, electrodes were encapsulated in beeswax from which two food-grade gold contacts (the foil used by pastry chefs) on a cellulose derived support come out.

The battery cell operates at 0.65 V, a voltage low enough not to create problems in the human body when ingested. It can provide current of 48 μA for 12 minutes, or a few microamps for more than an hour, enough to supply power to small electronic devices, such as low-power LEDs, for a limited time.

This example of fully edible rechargeable battery, the first one ever made, would open the doors to new edible electronic applications.

“Future potential uses range from edible circuits and sensors that can monitor health conditions to the powering of sensors for monitoring food storage conditions. Moreover, given the level of safety of these batteries, they could be used in children toys, where there is a high risk of ingestion. Actually, we are already developing devices with greater capacity and reducing the overall size. These developments will be tested in future also for powering edible soft robots”, pointed out the research coordinator Mario Caironi.

This edible battery is also very interesting for energy storage community. Building safer batteries, without usage of toxic materials, is a challenge we face as battery demand soars. While our edible batteries won’t power electric cars, they are a proof that batteries can be made from safer materials than current Li-ion batteries. We believe they will inspire other scientists to build safer batteries for truly sustainable future”, added Ivan Ilic, coauthor of the study.

Researchers decode the secret of bears in pursuit of new treatment against blood clots


Researchers at Aarhus University have used unconventional methods and spent 13 years mapping the hibernating bear's defence against blood clots. This could be the first step towards a new type of medication without side effects.

Peer-Reviewed Publication

AARHUS UNIVERSITY

Bear analysis 

IMAGE: RESEARCHERS FROM AARHUS UNIVERSITY, TOGETHER WITH GERMAN COLLEAGUES, HAVE SPENT 13 YEARS FIGURING OUT WHY BEARS DON'T GET BLOOD CLOTS AND LOSE MUSCLE MASS DURING HIBERNATION. THE RESULT COULD LEAD TO NEW GROUNDBREAKING DRUGS. view more 

CREDIT: OLE FRØBERT, AARHUS UNIVERSITY

For most people, prolonged inactivity is associated with an increased risk of developing blood clots due to limited blood flow in the veins. But why doesn't the same apply to bears that, with a resting heart rate of ten beats per minute, sleep through the winter months without moving at all?

This wonder more than 13 years ago led a team of researchers from Aarhus University, Aarhus University Hospital, and a group of German researchers to embark on an unusual research project - the goal was to decode the bear's secret.

Now, they have finally succeeded, and it turns out that the answer lies in a particular protein that normally helps fight inflammatory conditions in the body and ensures that blood clots when bleeding occurs.

"This protein is the key to a natural mechanism to protect the body against blood clots when it cannot move. This finding is very exciting as it has the potential to be of great importance for people at risk of developing blood clots due to inactivity," explains Professor Ole Frøbert of the Department of Clinical Medicine at Aarhus University.

Clotting blood platelets

Together with the team of researchers, he has previously demonstrated that the bear's blood platelets, which are essential for the development of blood clots, are less likely to stick together in the winter. To find the explanation for the less sticky blood platelets, the researchers took blood samples from wild bears in Sweden and compared the results between summer and winter.

"By meticulous examination of proteins from blood platelets, we discovered that the protein HSP47 was almost absent in the winter. And when we examined mice in which the gene that produces HSP47 was removed, we saw that the mice were hardly able to form blood clots," explains Ole Frøbert.

All bears have been sedated in connection with the studies, which are approved by the animal ethics authorities.

Treatment without side effects?

The question is whether it is possible to transfer the bear's natural mechanism to human physiology and, for example, activate it in patients who are forced to prolonged inactivity - e.g. people who are paralyzed due to spinal cord injuries.

There are already several drugs that are widely used to prevent blood clots. The common feature of all of them is that they are associated with the risk of bleeding, which can be life-threatening.

Therefore, Ole Frøbert sees great prospects for the development of new drugs against blood clots based on the findings of the study.

"There are many mechanisms that regulate blood coagulation, and we have demonstrated yet another. Since we have succeeded in downregulating HSP47 with gene manipulation in mice, we believe that the new mechanism may open up the development of a new type of gentle, preventive treatment with significantly lower risk of bleeding and other side effects," he says.

Further research in the field will include, among other things, studies of whether certain patients spontaneously activate downregulation of the HSP47 protein, as these will not require blood-thinning medication, for example, after a stroke.

"We are also continuing our research on the bear model, as it may potentially prove to be a Swiss Army knife with solutions to a wide range of major challenges. Currently, we are working to understand why bears - unlike inactive humans - do not lose muscle mass during hibernation," explains Ole Frøbert.

You can read more about the study, which has just been published in the journal Sciencehere:

About the study

  • Study type: Basic research. Translational research.
  • Collaborators: Department of Cardiology, LMU Munich; Max Planck Institute Munich; Örebro University Hospital; Scandinavian Brown Bear Research Project; Norwegian Institute for Nature Research. Funding: German Research Foundation; German Excellence Initiative; European Research Council; NASA; Norwegian Environment Agency; and the Swedish Environmental Protection Agency.
  • Conflicts of interest: None.
  • Link to publication: https://www.science.org/doi/10.1126/science.abo5044

Benefits of “zombie” cells: Senescent cells aid regeneration in salamanders

Scientists show that so called senescent cells, i.e., cells that have permanently stopped dividing, boost production of new muscle cells to enhance regeneration of lost limbs in salamanders.

Peer-Reviewed Publication

TECHNISCHE UNIVERSITÄT DRESDEN

Salamander 

IMAGE: THE SALAMANDER SPECIES STUDIED BY THE YUN GROUP: A RED SPOTTED NEWT NOTOPHTHALMUS VIRIDESCENS. view more 

CREDIT: MAXIMINA YUN

Senescent cells are cells that have permanently stopped dividing in response to cellular stress but have not died. As organisms age, the number of senescent cells in the body increases. This accumulation is currently considered one of the hallmarks of aging and has been linked to a variety of diseases, including cancer. However, the true nature of these cells may be more complex and context-dependent.

A growing body of evidence suggests that senescent cells may also have beneficial effects, such as wound healing or preventing tissue scarring. “A few years ago, our group found that senescent cells were present at key stages of salamander limb regeneration. Interestingly, other groups subsequently found these cells in other regeneration contexts, including in mammals. We therefore wanted to find out whether these cells contribute in any way to regeneration itself,” explains Dr. Maximina Yun, research group leader at the Center for Regenerative Therapies Dresden (CRTD) and the Cluster of Excellence Physics of Life (PoL) at TU Dresden and the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG).

Senescent Cells Promote Regeneration

The researchers in the Yun’s group study salamanders. These animals have unique regeneration abilities and are able to re-grow many organs of their bodies, including lost limbs. “Salamander limb regeneration is a fascinating process. In a matter of weeks, they re-grow a fully functional limb,” explains Dr. Yun.

To check if the presence of senescent cells influences the limb regeneration process, researchers in the Yun group found a way to modulate the number of senescent cells in the wound. The team observed that the presence of senescent cells enhanced the regeneration process.

“When more senescent cells were present in the wound, the animals developed a larger regeneration bud, or - as we call it – blastema. This is a collection of cells that are going to form all the needed tissues in the new limb. The larger the blastema, the more cells are there to regrow the limb and the quicker the regeneration process. The presence of senescent cells seemed to ‘fuel’ the regeneration process,” Dr. Yun says.

“Zombie” Signaling Promotes New Muscle Cells

Looking more closely at the blastema with and without the influence of the senescent cells, the Yun team uncovered a new mechanism that enhances the regeneration process and found that the presence of senescent cells increased the number of regenerating muscle cells. They showed that senescent cells secrete factors that stimulate nearby muscle tissue to take a developmental step back and produce new muscle.

“Our results show that senescent cells use cell-cell communication to influence the regeneration process. They secrete molecules that signal to mature muscle fibers to dedifferentiate into muscle progenitor cells. These cells can multiply themselves as well as differentiate into new muscle cells, thereby enhancing the regeneration process. This signaling appears to be an important part of promoting regeneration,” says Dr. Yun.

For now, the group focused on muscle, one of the most important tissues in the regenerating limb. However, the team is already investigating whether senescent cell signaling also contributes to the regeneration of other tissues.

Lessons From the Salamanders

Yun’s group is working with the salamanders to study regeneration and aging processes. “Salamanders are one of the few animal species that seem to defy the natural aging process. They do not develop typical signs of aging and do not accumulate age-related diseases such as cancer. They also have extraordinary healing abilities,” says Dr. Yun. The animals can regenerate almost any organ in their body.

Studying salamanders is helping Dr. Yun and her colleagues at the CRTD understand the principles of the regeneration process and, in the long run, may help solve the puzzle of why humans have very limited regenerative abilities.

Original Publication
Hannah E. Walters, Konstantin E. Troyanovskiy, Alwin M. Graf and Maximina H. Yun: Senescent cells enhance newt limb regeneration by promoting muscle dedifferentiation. Aging Cell (April 2023) Link: http://doi.org/10.1111/acel.13826

Resources:
Website of Dr. Yun’s group: https://tud.de/crtd/yun
Full resolution pictures: https://tud.link/2bx0

Assisted reproduction kids grow up just fine – but it may be better to tell them early about biological origins, twenty-year study suggests

Landmark study finds no difference in psychological wellbeing or quality of family relationships between children born by assisted reproduction (egg or sperm donation or surrogacy) and those born naturally at age 20


Peer-Reviewed Publication

UNIVERSITY OF CAMBRIDGE

Paper available at: https://drive.google.com/drive/folders/1y9GfgYkRdUtwyq6nBhySePTUHZYP6iAj?usp=share_link

  • Landmark study finds no difference in psychological wellbeing or quality of family relationships between children born by assisted reproduction (egg or sperm donation or surrogacy) and those born naturally at age 20.
  • However, findings suggest that telling children about their biological origins early – before they start school  can be advantageous for family relationships and healthy adjustment. 
  • THIS ALSO APPLIES TO ADOPTED CHILDREN

The study, by University of Cambridge researchers, is the first to examine the long-term effects of different types of third-party assisted reproduction on parenting and child adjustment, as well as the first to investigate prospectively the effect of the age at which children were told that they were conceived by egg donation, sperm donation or surrogacy.

The results, published today in Developmental Psychology, suggest that the absence of a biological connection between children and parents in assisted reproduction families does not interfere with the development of positive relationships between them or psychological adjustment in adulthood. These findings are consistent with previous assessments at age one, two, three, seven, ten and 14.

The findings overturn previous widely held assumptions that children born by third-party assisted reproduction are at a disadvantage when it comes to wellbeing and family relationships because they lack a biological connection to their parents.

“Despite people's concerns, families with children born through third-party assisted reproduction – whether that be an egg donor, sperm donor or a surrogate – are doing well right up to adulthood,” said Susan Golombok, Professor Emerita of Family Research and former Director of the Centre for Family Research, University of Cambridge, who led the study.

However, they found that mothers who began to tell their children about their biological origins in their preschool years had more positive relationships with them as assessed by interview at age 20, and the mothers showed lower levels of anxiety and depression. Most of the parents who had disclosed did so by age four and found that the child took the news well. This suggests that being open with children about their origins when they are young is advantageous.

In addition, in the final stage of this 20-year study, mothers who had disclosed their child’s origins by seven years old obtained slightly more positive scores on questionnaire measures of quality of family relationships, parental acceptance (mother’s feelings towards young adult), and family communication. For example, only 7% of mothers who had disclosed by age 7 reported problems in family relationships, compared with 22% of those who disclosed after age 7.

The young adults who had been told about their origins before seven obtained slightly more positive scores on questionnaire measures of parental acceptance (young adult’s perception of mother’s feelings towards them), communication (the extent to which they feel listened to, know what’s happening in their family and receive honest answers to questions), and psychological wellbeing. They were also less likely to report problems on the family relationships questionnaire; whereas 50% of young adults told after age 7 reported such problems, this was true of only 12.5% of those told before age 7.

“There does seem to be a positive effect of being open with children when they’re young – before they go to school – about their conception. It’s something that’s been shown by studies of adoptive families too,” said Golmobok.

Researchers from the University of Cambridge followed 65 UK families with children born by assisted reproduction ­– 22 by surrogacy, 17 by egg donation and 26 by sperm donation – from infancy through to early adulthood (20 years old). They compared these families with 52 UK unassisted conception families over the same period.

“The assisted reproduction families were functioning well, but where we did see differences, these were slightly more positive for families who had disclosed,” said Golombok.

Reflecting on their feelings about their biological origins, the young adults were generally unconcerned. As one young adult born through surrogacy put it, “It doesn’t faze me really, people are born in all different ways and if I was born a little bit differently - that’s OK, I understand.”

Another young adult born through sperm donation said, “My dad’s my dad, my mum’s my mum, I've never really thought about how anything’s different so, it's hard to put, I don’t really care.”

Some young adults actively embraced the method of their conception as it made them feel special, “I think it was amazing, I think the whole thing is absolutely incredible. Erm…I don’t have anything negative to say about it at all.”

Researchers found that egg donation mothers reported less positive family relationships than sperm donation mothers. They suggest that this could be due to some mothers’ insecurities about the absence of a genetic connection to their child. This was not reflected in the young adults’ perceptions of the quality of family relationships.

The team also found that young adults conceived by sperm donation reported poorer family communication than those conceived by egg donation. This could be explained by the greater secrecy around sperm donation than egg donation, sometimes driven by greater reluctance of fathers than mothers to disclose to their child that they are not their genetic parent, and a greater reluctance to talk about it once they have disclosed.

In fact, researchers found that only 42% of sperm donor parents disclosed by age 20, compared to 88% of egg donation parents and 100% of surrogate parents.

“Today there are so many more families created by assisted reproduction that it just seems quite ordinary,” said Golombok. “But twenty years ago, when we started this study, attitudes were very different. It was thought that having a genetic link was very important and without one, relationships wouldn’t work well.

“What this research means is that having children in different or new ways doesn’t actually interfere with how families function. Really wanting children seems to trump everything – that’s what really matters.”

This research was funded by a Wellcome Trust Collaborative Award.

The Centre for Family Research is collaborating with the Fitzwilliam Museum on a new exhibition, Real Families: Stories of Change (October – 7 January 2024), curated by Professor Golombok. The exhibition will explore the intricacies of families and family relationships through the eyes of artists including Paula Rego, Chantal Joffe, JJ Levine, Lucian Freud and Tracey Emin.

Professor Susan Golombok is author of We Are Family: What Really Matters for Parents and Children (Scribe) which describes researching new family forms from the 1970s to the present day.

ENDS.

Reference:

Golombok, S., Jones, C., Hall, P., Foley, S., Imrie, S., &  Jadva, V. A longitudinal study of families formed through third-party assisted reproduction: Mother-child relationships and child adjustment from infancy to adulthood. Developmental Psychology DOI: 10.1037/dev0001526

Jadva, V., Jones, C. M., Hall, P., Imrie, S., & Golombok, S. “I know it’s not normal but it’s normal to me and that’s all that matters”: The experiences of young adults conceived through egg donation, sperm donation and surrogacy. Human Reproduction DOI: 10.1093/humrep/dead048

Contact details:

Charis Goodyear, University of Cambridge Charis.Goodyear@admin.cam.ac.uk

Professor Susan Golombok, University of Cambridge seg42@cam.ac.uk

About the University of Cambridge

The University of Cambridge is one of the world’s leading universities, with a rich history of radical thinking dating back to 1209. Its mission is to contribute to society through the pursuit of education, learning and research at the highest international levels of excellence.

Cambridge was second in the influential 2023 QS World University Rankings, the highest rated institution in the UK.

The University comprises 31 autonomous Colleges and over 100 departments, faculties and institutions. Its 20,000 students include around 9,000 international students from 147 countries. In 2022, 72.5% of its new undergraduate students were from state schools and more than 25% from economically disadvantaged backgrounds.

Cambridge research spans almost every discipline, from science, technology, engineering and medicine through to the arts, humanities and social sciences, with multi-disciplinary teams working to address major global challenges. In the Times Higher Education’s rankings based on the UK Research Excellence Framework, the University was rated as the highest scoring institution covering all the major disciplines.

The University sits at the heart of the ‘Cambridge cluster’, in which more than 5,200 knowledge-intensive firms employ more than 71,000 people and generate £19 billion in turnover. Cambridge has the highest number of patent applications per 100,000 residents in the UK.

www.cam.ac.uk

Real Families: Stories of Change

6 October – 7 January 2024

Real Families is a major exhibition exploring the intricacies of families and family relationships through the eyes of artists. The theme of the family has been interpreted and represented for centuries, but, especially during the last fifty years, Western ideas of what makes a family and how family life is experienced have been transformed by advances in science and by changes in social attitudes and law. Developed in collaboration with the world-leading Centre for Family Research at the University of Cambridge, the exhibition shows how the joys, tensions and transitions in families have little to do with conforming to traditional structures. Instead, acceptance, rejection, conflict and comfort arise from relationships within family groups of all kinds, and through connections with the outside world. Painting, photography, video, sculpture and installations by artists including Paula Rego, Chantal Joffe, JJ Levine, Lucian Freud and Tracey Emin tell moving and enduring stories of intimacy, alienation and everything in between.

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DOI

SUBJECT OF RESEARCH

ARTICLE TITLE

ARTICLE PUBLICATION DATE

Friday, April 14, 2023

SFU professor unearths the ancient fossil plant history of Burnaby Mountain


Peer-Reviewed Publication

SIMON FRASER UNIVERSITY

Plant fossils 

IMAGE: FIG. 4. REPRODUCTIVE PLANT MACROFOSSILS FROM THE SIMON FRASER UNIVERSITY EXPOSURE. A, PARTIAL TRILOBED FRUITING BRACT OF PALAEOCARYA CF. P. WOLFEI, SIMILAR TO BRACTS OF LIVING ENGELHARDIA. B, FRUIT VALVE OF THE MALVACEOUS CRAIGIA. C, LIQUIDAMBAR FRUIT CLUSTER SHOWING THE WOODY ELONGATED STYLES OF THE EMBEDDED CAPSULES. D, STERILE FLOWER OF HYDRANGEA. E, FLORAL CALYX OF FLORISSANTIA CF. F. SPEIRII. THE SPECIES IS UNCERTAIN BUT BASED ON THE LARGE SIZE OF THE CALYX (DIAMETER = 51 MM), WHICH IS MOST SIMILAR TO F. SPEIRII. ALL SCALES ARE IN MILLIMETERS. view more 

CREDIT: SIMON FRASER UNIVERSITY

New research led by Simon Fraser University paleobotanist Rolf Mathewes provides clues about what plants existed in the Burnaby Mountain area (British Columbia, Canada) 40 million years ago during the late Eocene, when the climate was much warmer than it is today. The results of their plant fossil analysis were recently published in the International Journal of Plant Sciences.

Mathewes as an undergraduate, and his supervisor at the time, professor Robert C. Brooke, found and collected plant fossils from a deposit exposed during the construction of the university in the late 1960s. The fossils were kept at SFU but remained locked away in cabinets for many years until Mathewes returned to the collection as a professor. He dedicates the paper to the memory of Brooke, his late supervisor and mentor.

One of the fossils identified by their colleague David Greenwood, from Brandon University, is of a palm leaf fragment. The team also identified a hydrangea flower and the flower of an extinct plant from the same family as the basswood, a tree native to Eastern North America. A microscopic analysis of fossil pollen extracted from the fine shale also reveals the presence of alders, ferns, elms, sweetgum, and many other plants.

 “These plant fossils tell us the climate was warm temperate to subtropical because of the presence of palms,” says Mathewes, study lead and SFU professor of paleoecology & palynology. “If you wanted an analogue for what the climate was like compared to today, the conditions would be similar to the East Coast of the United States somewhere around Wilmington, North Carolina, where palms are still native today.”  

Study co-author Tammo Reichgelt (University of Connecticut) used new climate modelling techniques to confirm the warmer conditions.

Although planted palms can be found growing in the Lower Mainland today, Mathewes notes that these plants would not survive here on their own as they did in the distant past.

“Even if they flowered and produced seeds, their young seedlings would never be able to compete with the seedlings of Douglas fir and hemlocks and alders that are our native vegetation and probably would die in the first hard frost of winter,” he says.

He explains that most of Burnaby Mountain is comprised of sandstone and gravel but the fossils are only preserved on shale or mudstone. In the late Eocene, Burnaby Mountain had not yet formed and was a floodplain, like the Fraser River Delta, with ponds and river channels with vegetation growing near sea level.

The plants and trees growing on the floodplain deposited their leaves, flowers and pollen into the fine sediment of a shallow lake or pond. Their fossils formed through a process of being compressed under layers of sediment for millions of years.

One of the fossil leaves clearly displays round feeding marks made by an insect, and Mathewes says there is still much to be discovered, identified and studied from the pollen samples and a second fossil deposit site.

Fig. 7. A, Large leaf of cf. Anacardites franklinensis, a species defined by Wolfe from the Eocene Puget Group. B, One of several leaf fragments of an uncertain Myrtaceae (Syzgoides), based on an entire-margined leaf with a strong midvein and thin, closely spaced eucamptodromous secondaries that connect to an intramarginal vein (arrow). C, Unidentified cordate leaf with actinodromous venation, entire margin, and fimbrial vein visible along lower margin, suggestive of Menispermaceae. D, Insect body fossils have not been found in the Burnaby Mountain sediments, but some examples of insect leaf damage are present, like this unidentified dicot leaf with rounded skeletonized feeding spots. All scales are in millimeters.