Saturday, December 30, 2023

Climate scientists hail 2023 as ‘beginning of the end’ for fossil fuel era

Jillian Ambrose Energy correspondent
THE GUARDIAN
Fri, 29 December 2023 

Photograph: Alexisaj/Alamy

Global efforts to slow a runaway climate catastrophe may have reached a critical milestone in the last year with the peak of global carbon emissions from energy use, according to experts.

A growing number of climate analysts believe that 2023 may be recorded as the year in which annual emissions reached a pinnacle before the global fossil fuel economy begins a terminal decline.

The milestone is considered a crucial tipping point in the race to drive emissions to net zero. But for many climate experts it’s an inflexion point that was due years ago and which, although encouraging, falls far short of the rapid reduction the world needs.


The world’s leading climate scientists have consistently warned that the buildup of carbon dioxide in the Earth’s atmosphere means it is critical to drive down emissions before 2030 if leaders hope to keep global heating to a maximum of 1.5C above pre-industrialised levels. The rate at which emissions would need to be reduced will require, most experts agree, global transformation on a scale not yet in the pipeline.

“We can take a small pause to celebrate this tipping point,” said Dave Jones, a director at the climate thinktank Ember. “But in a way it’s worrying that we are still talking about when emissions might peak. The reality of the situation is that we need deep and fast reductions in emissions if we hope to stay within the vanishingly small budget for carbon which remains.”

The International Energy Agency (IEA) raised hopes earlier this year of an end to the fossil fuel era when it predicted for the first time that the consumption of oil, gas and coal would peak before 2030 and begin to fall as climate policies took effect.

“It’s not a question of ‘if’, it’s just a matter of ‘how soon’ – and the sooner the better for all of us,” said Fatih Birol, the head of the IEA.Interactive

To understand how the world may have already reached an end to rising global emissions, just two years after one of the steepest emissions hikes in history, it helps to look at the global electricity sector.

“The world is teetering at the peak of power sector emissions,” said Malgorzata Wiatros-Motyka, the lead author of a report by Ember. Earlier this year the report found that emissions from generating electricity had plateaued over the first half of 2023 and could be poised to fall from next year.

The report studied power generation across 78 countries representing 92% of global electricity demand. It found a 16% rise in the amount of solar power generated and a 10% jump in global wind power output.

In the IEA’s flagship report, widely considered to be one of the most influential in the climate and energy debate, it found that the steady rise of wind and solar power was on track to outpace the world’s growing demand for energy – meaning renewables will start to displace fossil fuels on a global scale.

Related: The year the world labelled fossil fuels as the problem – podcast

At the same time the rollout of electric vehicles globally is expected to start eroding the demand for road fuels, which makes up about 50% of the oil demand in developed countries.

These trends have accelerated since Russia’s invasion of Ukraine, which triggered a surge in the commodity price for gas and oil in 2022 and incentivised a renewed focus on securing domestic sources of clean energy instead.

In one scenario put forward by the IEA, based on the stated policies of global governments, it found that emissions may peak as soon as this year before beginning a slow decline. The IEA is careful to say that none of its scenarios should be considered a forecast. The “stated policies” scenario is one of the more reliable barometers of what the future may hold because it is based on “a detailed review of the current policy landscape”, or in other words, what governments are doing rather than what they are say they will do.

The findings are backed up by a number of separate studies, all from well-regarded energy authorities, which paint a picture of a world at the beginning of the end of the fossil fuel era.Interactive

An analysis of China’s carbon emissions – the highest in the world and more than the emissions of the US, India and Russia combined – found that they may reach a peak this year before falling into a structural decline by 2024. The study by the Centre for Research on Energy and Clean Air, undertaken for Carbon Brief, found that China’s rollout of wind and solar power had been faster than expected this year and could eclipse the country’s growing energy appetite.

A peak in China’s emissions this year was also found by Climate Analytics, a climate policy institute, which predicted that an emissions peak for the world’s most energy-hungry nation could drive the world to an emissions “tipping point” in 2023.

Dr Neil Grant, an author of the report, said: “For years, energy demand growth has outstripped renewables deployment, despite record additions of wind and solar. We’re now approaching the tipping point, where renewables overtake demand growth and start displacing coal, oil and gas. This would mark the beginning of the end for the fossil economy.”

There is a note of caution in the prediction though. Claire Fyson, another author of the Climate Analytics report, warned that the existing trends seeing rising renewables and electric motoring would need to continue to allow emissions to begin falling.

“This won’t just happen by itself,” Fyson said. “Technologies often follow an ‘S’ curve where they really take off but over time their progress can slow. You need government policy to continue to incentivise renewables and [disincentivise] fossil fuels.”

Related: ‘The future is renewable’: How a huge gamble sealed Cop28 deal

Not everyone agrees that fossil fuels have reached the beginning of the end. Some of the biggest oil producers in the world have publicly stated that oil demand – and emissions – show no sign of falling.

The US Energy Information Administration’s (EIA) said earlier this year that energy-related carbon emissions would continue to rise, in line with growing global demand for oil, until 2050. The Organization of the Petroleum Exporting Countries (Opec) has also predicted that global oil demand will continue to grow out to 2045, albeit at a slower pace than in recent years.

“I think you have to think about the motives behind these projects,” said Fyson. “It’s in Opec’s best interest to forecast a rise in oil demand.”

Strong oil demand forecasts can create a self-fulfilling prophecy. They might encourage governments to back further oil and gas exploration to avoid a shortfall, which in turn can lead to lower oil commodity prices if there is more oil and gas than needed. This creates a disincentive to switch from a fossil fuel vehicle or heating system to an electric alternative if it’s cheaper to use gas or oil.

Opec has consistently underestimated the rollout of electric vehicles in its official forecasts, which are used by governments to inform their policies, according to experts. Its forecasts for the number of electric vehicles on the roads by 2022 were too low by an average of almost 60% over the period 2015-2021, according to a recent report by Zero Carbon Analytics. In 2021, the cartel’s forecasts for the global electric vehicles fleet just one year ahead were wrong by 49%, the report found.

Amy Kong, the author of the report, said the forecasts were “wildly wrong year after year” in what appears to be an “underhand attempt by oil producers to persuade investors and governments that fossil fuels have a future”.

Related: The Guardian view on Cop28’s final text: saying the right thing – and not a moment too soon | Editorial

Even in a world of declining fossil fuels and carbon emissions there is a clear risk of failing to move fast enough to reduce emissions in time to prevent global heating of 1.5C above pre-industrialised levels, according to climate experts.

The United Nations Environment Programme estimates that for the world to have a shot at keeping global heating below the 1.5C target set out in the Paris agreement emissions will need to fall by about 9% every year. For context, emissions fell 5.4% when the Covid-19 pandemic brought global economies to a standstill in 2020 before starting to rise again.

There will need to be great strides in addressing the world’s record high carbon emissions, but from next year there’s a strong chance that at least they will be moving in the right direction.

 

Self-reported frequency of adding salt to food and risk of incident chronic kidney disease

JAMA Network Open

Peer-Reviewed Publication

JAMA NETWORK



About The Study: In this study of 465,000 individuals, a higher self-reported frequency of adding salt to foods was associated with a higher risk of chronic kidney disease in the general population. These findings suggest that reducing the frequency of adding salt to foods at the table might be a valuable strategy to lower chronic kidney disease risk in the general population. 

Authors: Lu Qi, M.D., Ph.D., of Tulane University in New Orleans, is the corresponding author. 

 To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2023.49930)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2023.49930?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=122823

 

New agent regulates serotonin production


Berlin based Start-up aims to bring down high levels of Serotonin


Business Announcement

MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE IN THE HELMHOLTZ ASSOCIATION

Trypto Therapeutics 

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Radoslaw Wesolowski (left), Michael Bader (center) and Dr. Edgar Specker have teamed up to develop a potential therapeutic agent that influences serotonin levels.

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CREDIT: PETER HIMSEL / CAMPUS BERLIN-BUCH GMBH





Serotonin makes you feel good. This neurotransmitter known as the “happiness hormone” regulates mood, sleep, and appetite. It also plays a key role in the gastrointestinal tract, where it is involved in regulating intestinal movement and the release of fluids that are important for the digestion and absorption of nutrients.

But too much serotonin causes health problems. An oversupply of the hormone can disrupt normal bodily functions and trigger various diseases. Professor Michael Bader and Dr. Edgar Specker have developed a drug that specifically lowers serotonin levels. Bader leads the Molecular Biology of Peptide Hormones Lab at the Max Delbrück Center, while Specker heads the Compound Management Core Facility at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP). “We have now founded Trypto Therapeutics to bring our new therapeutic agent to the market,” says Bader. Along with the two scientists, biotech entrepreneurs Dirk Pleimes and Dr. Radoslaw Wesolowski are also involved in the new company. Max Delbrück Center and the FMP have an equity stake in the spin-off.

Stopped by the blood-brain barrier

Scientists don’t know exactly why serotonin production gets out of whack. An exception is carcinoid syndrome, a tumor disease in which hormone-producing cells release inordinate amounts of serotonin. Carcinoid syndrome is often associated with diseases like pulmonary hypertension, intestinal diseases, and heart valve fibrosis. However, they can also occur in patients without carcinoid syndrome. As different as these diseases are, elevated serotonin is involved in the development of all of them.

This is where the molecule that Bader and Specker discovered and further developed in the FMP’s compound library comes into play. It is called TPT-004 and inhibits an enzyme found in gastrointestinal tract cells, called tryptophan hydroxylase (TPH), that plays a role in serotonin synthesis. Lower TPH activity means less serotonin circulating through the body. The researchers showed that the administration of TPT-004 improves the health of rats with pulmonary hypertension. They were also able to prove that this molecule cannot cross the blood-brain barrier in mice. This is important because serotonin is also produced in the neurons – a process that should not be blocked because the brain requires the neurotransmitter to function properly.

Venture capital needed to move forward

A great deal of funding has gone into developing the TPH inhibitor so far – through the Max Delbrück Center’s Pre-GoBio funding scheme, through various lines of funding from the German Federal Ministry of Education and Research (BMBF) and, most recently, through the Max Delbrück Center’s SPOT spin-off support program. “We’ve received around €4.5 million in total,” says Bader. “But public third-party funding is not enough to take the next step. We need venture capital to do this. That’s why we founded Trypto Therapeutics.”

The scientists first plan to develop a method for producing their therapeutic agent in pure form in sufficient quantities so that it can be used in human clinical trials. They will also carry out a toxicity study in order to investigate the risks and possible side effects of the compound. Only then will it be possible to conduct a phase I clinical trial on a small group of healthy volunteers. “If we successfully complete the phase I trial, we will then decide whether to conduct a subsequent phase II study or sell the whole thing,” says Bader. The researchers initially want to test the drug on patients with pulmonary hypertension. If this works, they want to examine whether TPT-004 helps treat other diseases associated with elevated serotonin levels. Their development pipeline also includes new inhibitors for other enzymes.

Joint press release by Max Delbrück Center and FMP

 

Further information


Contacts

Professor Michael Bader
Head of the lab “Molecular Biology of Peptide Hormones”
Max Delbrück Center
+49 (0)30 9406 2193
mbader@mdc-berlin.de

Christina Anders
Editor, Communications Department
Max Delbrück Center
+49 (0)30 9406 2118
christina.anders@mdc-berlin.de or presse@mdc-berlin.de

 

Max Delbrück Center

The Max Delbrück Center for Molecular Medicine in the Helmholtz Association (Max Delbrück Center) is one of the world’s leading biomedical research institutions. Max Delbrück, a Berlin native, was a Nobel laureate and one of the founders of molecular biology. At the locations in Berlin-Buch and Mitte, researchers from some 70 countries study human biology – investigating the foundations of life from its most elementary building blocks to systems-wide mechanisms. By understanding what regulates or disrupts the dynamic equilibrium of a cell, an organ, or the entire body, we can prevent diseases, diagnose them earlier, and stop their progression with tailored therapies. Patients should be able to benefit as soon as possible from basic research discoveries. This is why the Max Delbrück Center supports spin-off creation and participates in collaborative networks. It works in close partnership with Charité – Universitätsmedizin Berlin in the jointly-run Experimental and Clinical Research Center (ECRC), the Berlin Institute of Health (BIH) at Charité, and the German Center for Cardiovascular Research (DZHK). Founded in 1992, the Max Delbrück Center today employs 1,800 people and is 90 percent funded by the German federal government and 10 percent by the State of Berlin.

 

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)

What keeps us healthy, what makes us sick? How does a drug reach the right site of action in the body and thus spare patients from side effects? And how can viruses and bacteria be prevented from entering cells? To answer these questions, researchers at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) investigate biochemical processes in the body and study the molecular causes of diseases. Based on these findings, scientists can also specifically search for active substances and thus develop the basis for the medicine of tomorrow. Interdisciplinary teams from the fields of biochemistry, chemistry, physics, and medicine work together in a unique working environment on the Campus Berlin-Buch. The FMP is part of the Forschungsverbund Berlin e.V. (FVB), which legally represents seven non-university research institutes - members of the Leibniz Association - in Berlin.


 

AI

Machine learning methods to protect banks from the risks of complex investment products


Peer-Reviewed Publication

KEAI COMMUNICATIONS CO., LTD.

Performances of the proposed method compared to optimal strategy 

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PERFORMANCES OF THE PROPOSED METHOD COMPARED TO OPTIMAL STRATEGY

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CREDIT: CANNELLI, L., NUTI, G., SALA, M., AND SZEHR, O.




Artificial Intelligence (AI) is frequently touted as a silver bullet to solve complex modeling problems. Among its many applications, it has been investigated as a tool to manage risks of complex investment products—so-called derivative contracts—in the investment banking area. Despite the multiple positive reports in this area, concerns have been raised about their practical applicability.

In a new study published in The Journal of Finance and Data Science, a team of researchers from Switzerland and the US explored whether reinforcement learning RL agents can be trained to hedge derivative contracts.

"It should come as no surprise that if you train an AI on simulated market data, it will work well on markets that are reflective of the simulation, and the data consumption of many AI systems is outrageous," explains Loris Cannelli, first author of the study and a researcher at IDSIA in Switzerland.

To overcome the lack of training data, researchers tend to assume an accurate market simulator to train their AI agents. However, setting up such a simulator leads to a classical financial engineering problem: choosing a model to simulate from and its calibration, and making the AI-based approach much like the standard Monte Carlo methods in use for decades.

“Such an AI can also be hardly considered model-free: this would apply only if enough market data was available for training, and this is rarely the case in realistic derivative markets,” says Cannelli.

The study, a collaboration between IDSIA and investment bank of UBS, was based on so-called Deep Contextual Bandits, which are well-known in RL for their data-efficiency and robustness. Motivated by operational realities of real-world investment firms, it incorporates end of day reporting requirements and is characterized by a significantly lower training data requirement compared to conventional models, and adaptability to the changing markets.

"In practice, it's the availability of data and operational realities, such as requirements to report end-of-day risk figures, that are the main drivers that dictate the real work at the bank, instead of ideal agent training," clarifies senior author Oleg Szehr, whom, prior to his appointment at IDSIA, was a staff member at several investment banks. “One of the strengths of the newly developed model is that it conceptually resembles business operations at an investment firm and thus is applicable from a practical perspective.”

Although the new method is simple, rigorous assessment of model performance demonstrated that the new method outperforms benchmark systems in terms of efficiency, adaptability and accuracy under realistic conditions. “As often the case in real life, less is more—the same applies to risk management too,” concludes Cannelli.

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Contact the author: Oleg Szehr, Dalle Molle Institute for Artificial Intelligence (IDSIA) – SUPSI/USI, oleg.szehr@supsi.ch

The publisher KeAi was established by Elsevier and China Science Publishing & Media Ltd to unfold quality research globally. In 2013, our focus shifted to open access publishing. We now proudly publish more than 100 world-class, open access, English language journals, spanning all scientific disciplines. Many of these are titles we publish in partnership with prestigious societies and academic institutions, such as the National Natural Science Foundation of China (NSFC).

 

Extremes of mobility: Lessons from Los Angeles' transportation policy unveiled in new book


Book Announcement

WORLD SCIENTIFIC

Extremes of Mobility: Development and Consequences of Transport Policy in Los Angeles 

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COVER FOR "EXTREMES OF MOBILITY: DEVELOPMENT AND CONSEQUENCES OF TRANSPORT POLICY IN LOS ANGELES"

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CREDIT: WORLD SCIENTIFIC




The development of transportation policy in Los Angeles is a story of extremes. New book by director and founder of the independent Center of Automotive Management (CAM) at the University of Applied Sciences in Bergisch Gladbach, sheds light on the city’s extreme shifts in mobility policies and their enduring consequences. From boasting the world's largest regional rail network in the 1920s to its current status as a symbol of car-oriented mobility, the city's journey reflects global trends, offering invaluable insights for policymakers worldwide.

The book, tracing the history of transportation policy in Los Angeles up to the present day, reveals the pitfalls of supply- and infrastructure-oriented approaches. Despite massive investments in a local public transport system since the 1990s, traffic problems persist, exemplifying the self-reinforcing cycle of increasing demand and worsening congestion. The findings underscore the need for a nuanced understanding of the spatial, social, and economic interdependencies inherent in transport policy.

One crucial revelation from the analysis is the counterintuitive impact of road expansion. Contrary to expectations, Extremes of Mobility: Development and Consequences of Transport Policy in Los Angeles demonstrates that the supply-oriented expansion of expressways and motorways exacerbates traffic congestion rather than alleviating it. Los Angeles serves as a cautionary tale for other cities globally, as similar trends of spatial separation between living and working unfold, leading to increased commuting distances and traffic woes.

The global relevance of Los Angeles' experience is underscored by comparisons with Germany, where commuter numbers have surged to a new high of 20.3 million in 2022. The challenges faced by major German cities, such as Munich, mirror those of Los Angeles, emphasizing the universal applicability of the lessons drawn from the extreme case study. The book concludes that a sustainable solution to metropolitan region problems demands a holistic understanding of transport's origins, spatial dynamics, and social and economic impacts. Policies emphasizing infrastructure expansion or commuter incentives without considering these factors risk perpetuating ecologically and socially detrimental patterns that are challenging to reverse.

Extremes of Mobility: Development and Consequences of Transport Policy in Los Angeles retails for US$88 / £80 (hardcover) and is also available in electronic formats. To order or know more about the book, visit http://www.worldscientific.com/worldscibooks/10.1142/13474.

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About the Author

Stefan Bratzel is director and founder of the independent Center of Automotive Management (CAM) at the University of Applied Sciences in Bergisch Gladbach. After completing his studies in political science and later earning his doctorate, Bratzel worked in and around the auto industry. Among other positions, he has held posts as a project manager at the Daimler subsidiary smart, as program manager Automotive at the Telefonica/Sonera subsidiary Group3G, and as the head of Business Development Automotive at PTV AG. Since April 2004, he has worked as a senior lecturer and course program director for automotive management at the University of Applied Sciences in Bergisch Gladbach (Cologne area). In his research, Stefan Bratzel deals with the conditions for success and survival of automobile manufacturers and suppliers as well as future questions of mobility. Based on empirical studies, he examines the innovation trends in the automotive industry and the evolving mobility ecosystem. As a well-known industry expert, he is one of the most cited automobile economists in Germany in the press, radio and television.

About World Scientific Publishing Co.

World Scientific Publishing is a leading international independent publisher of books and journals for the scholarly, research and professional communities. World Scientific collaborates with prestigious organisations like the Nobel Foundation and US National Academies Press to bring high quality academic and professional content to researchers and academics worldwide. The company publishes about 600 books and over 170 journals in various fields annually. To find out more about World Scientific, please visit www.worldscientific.com.

For more information, contact WSPC Communications at communications@wspc.com.