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Tuesday, January 13, 2026


Big Data Is a Bad Idea: Why AI Factory Farms Will Not Save Rural America

AI data centers have been added to the limited menu for economic development in marginalized US communities, but people in those communities have good reason to oppose them.


A sign on a rural Michigan road opposes a planned $7 billion data center on southeast Michigan farm land in Saline, Michigan on December 1, 2025.
(Photo by Jim West/UCG/Universal Images Group via Getty Images)

John Peck
Jan 12, 2026
Common Dreams


One word—plastics. That was the golden grail that Dustin Hoffman learned about from some well-wisher in the movie The Graduate. I remember watching the film as a farm kid and thinking about the updated version I was being told by my guidance counselors—one word: computers. We are now in the midst of the “Fourth Industrial Revolution” and the latest mantra is: artificial intelligence. Such free advice, though, could really be a costly warning in disguise.

Granted, there is a lot of poverty in the “richest” nation on Earth, and marginalized US communities often have few choices for economic (mal) development. It becomes a twisted game of pick your own poison: supermax prison, toxic waste dump, ethanol facility, tar sands pipeline… Now, AI data centers have been added to the limited menu. Someone recently shared a map of looming AI data centers across the world. It reminded me of how a tumor spreads and Edward Abbey’s quote that “growth for the sake of growth is the ideology of the cancer cell.”



Big Tech Ramps Up Propaganda Blitz As AI Data Centers Become Toxic With Voters



US Electric Grid Heading Toward ‘Crisis’ Thanks to AI Data Centers

The fact that Big Data has targeted Rural America for its latest mastitis should be no surprise. We have lots of available land to grab, thanks to the legacy of settler colonialism and family-farm foreclosure. Back in August I remember driving past Beaver Dam, Wisconsin and watching bulldozers flattening over 800 acres along Hwy 151 and my first hunch was: data center. Sure enough, the secretive $1 billion deal with Meta was finally revealed in a November press release. Just north of Madison in the town of DeForest, Blackstone subsidiary QTS Realty Trust is aiming to build another $12 billion data center on close to 1,600 acres. And if we need to free up more land for AI, we quaint rural folks could just abandon growing real Xmas trees and force people to buy plastic ones instead, as one Fox News “expert” suggested over the holidays. Former President Joe Biden visited Mt. Pleasant, Wisconsin in May 2024 to promote Microsoft’s new $3.3 billion 300+ acre AI campus on the former site of flat screen maker, Foxconn, that welcomed President Donald Trump for its groundbreaking back in 2018. Foxconn abandoned that $10 billion project and its 13,000 job promise, after getting millions in state subsidies and local tax deferrals.

The Microsoft AI complex in Mt. Pleasant will also require over 8 million gallons of water per year from Lake Michigan. We still have some clean water, though that may not last long thanks to agrochemical monocultures, CAFO manure dumping, and PFAS-laden sludge spreading. And AI certainly is thirsty—the Alliance for the Great Lakes noted in its August 2025 report that a hyperscale AI data center needs up to 365 million gallons of water to keep itself cool—that is as much water as is needed by 12,000 people! A recent investigative report by Bloomberg News found that over two-thirds of the AI data centers built since 2022 are in parts of the country already facing water stress. And it is really hard to drink data.

But is all the AI hype just another bubble about to burst? Rural communities (and public taxpayers) have been offered many “amazing” schemes in the past that ended up being just a “bait and switch”—another hollow promise.

In the Midwest we also have potential access to vast electricity (fracked natural gas, wind and solar farms, methane digesters), and relatively under-stressed high voltage grids (unlike California or Texas), though the loss of “cheaper” imported Canadian hydropower with the latest trade war could be a serious challenge. In 2023 the US had over a $2 billion electricity trade deficit vis-a-vis Canada. According to a recent Clean Wisconsin report, just two of our proposed AI data centers will require 3.9 gigawatts—1.5 times the current power demand of all 4.3 million homes in the state.

But, no worry, there are dilapidated US nuclear reactors with massive waste dumps that could be put back online such as Palisades in Michigan, despite opposition from environmental activists and family farmers. The Trump administration also just announced a $1 billion low-interest loan to reanimate Three Mile Island in Pennsylvania for the sake of AI. Until all that happens, though, regular ratepayers can expect a huge hike in their energy bills as Big Data has the market clout to siphon off what it needs first, especially as it colludes with utility monopolies. Many people in Wisconsin are already paying for $1+ billion in stranded assets—mostly defunct coal plants, as well as nuclear waste storage facilities—while utility investors continue to receive guaranteed dividends of 9-10%.

But is all the AI hype just another bubble about to burst? Rural communities (and public taxpayers) have been offered many “amazing” schemes in the past that ended up being just a “bait and switch”—another hollow promise. If we subsidize a massive data center, will the projected “market” for increasing algorithms actually come? Many within the AI industry don’t think so, and are now invoking the lessons we should have learned from the Enron scandal decades ago or the even worse sequel in the subprime mortgage-fueled financial meltdown. Corporate cheerleaders can be quite clever when it comes to inflating prices (and stocks) for goods and services that may not even exist, while hiding their massive debt obligations in a whole cascading series of shadowy shell subsidiaries and dishonest accounting shenanigans.

Many industry insiders are ringing alarm bells. “These models are being hyped up, and we’re investing more than we should,” said Daron Acemoglu, who won the 2024 Nobel Economics Prize, quoted in a recent NPR story about the current AI boom or bubble. OpenAI says it will spend $1.4 trillion on data centers over the next eight years, while Amazon, Google, Meta, and Microsoft are going to throw in another $400 billion. Meanwhile, just 3% of people who use AI now pay for it, and many are frantically trying to figure out how to turn off AI mode on their internet searches and to reject AI eavesdropping on their Zoom calls. Where is the real revenue going to come from to pay for all this AI speculation? The same NPR story notes that such a flood of leveraged capital is equal to every iPhone user on Earth forking over $250 to “enjoy” the benefits of AI—and “that’s not going to happen,” adds Paul Kedrosky, a venture capitalist who is now a research fellow at MIT’s Institute for the Digital Economy. Morgan Stanley estimates AI companies will shell out $3 trillion by 2028 for this data center buildout—but less than 50% of that money will come from them. Hmmm...

Special purpose vehicle (SPV) may sound like a fancy name for a retrofitted tractor, but that is how Big Data is creating a Potemkin Village to hide their Ponzi Scheme. Here is one example from Richland Parish, Louisiana where Meta is now building its Hyperion Data Center—a massive $27 billion project. A Wall Street outfit, Blue Owl, borrows $27 billion, using Meta’s future rent payments for a data center to back up its loan. Meta’s 20% “mortgage” on the facility gives them 100% control of the purported data crunching from the facility. This debt never shows up on Meta’s books and remains hidden from carefree investors and shallow analysts, but, like other synthetic financial instruments such as the now infamous mortgage backed security (MBS), the reality only comes home to roost when the house of cards collapses and Meta has to eventually pay off Blue Owl.

In the meantime, as the Louisiana Illuminator reports, the residents of Richland Parish (where 25% live below the poverty level) are bearing the brunt of all the real costs of having an AI factory farm. Dozens of crashes involving construction vehicles; damage to local roads; and massive future energy demands (three times that required for the entire city of New Orleans), which will entail new natural gas power plants to be built (subsidized by existing ratepayers even as fossil fuel-induced climate change floods the Louisiana delta). Beyond the initial building flurry, AI data centers are ultimately job poor. It just doesn’t take that many people to tend computers once they are built. As Meta’s VP, Brad Smith, admitted, the 250,000 square foot Hyperion data center may need 1,500 workers to build but barely 50 to operate. Beyond all the ballyhoo, the main reason a particular community is chosen to “host” one seems to be based upon the bought duplicity of elected officials and the excessive generosity of local taxpayers. Not a good cost-benefit analysis—unless you are Big Data.

And then there are the questionable kickback schemes between the suppliers of the technology and those owning the data centers. If you are maker of computer chips, would you not be tempted to fork over capital to a major buyer of your own products to ensure future demand? Nvidia just announced a $100 billion stake in OpenAI to help bankroll the data centers. In turn OpenAI signed a $300 billion deal with Oracle to actually build the AI data centers that will require Nvidia’s graphics processing units (GPUs). OpenAI also signed a separate $6+ billion deal with former BitCoin miner, CoreWeave, which rents out internet cloud access (using Nvidia’s chips once again). This type of incestuous circular financing should raise eyebrows to anyone who studies business ethics—and perhaps remind others of how a toilet operates.

What is all this AI doing? Promoters will point to many innovations—faster screening for cancer cells, closer connection to far-flung relatives, precision application of fertilizers and pesticides, elimination of drudgery in the workplace through automation. A bright future indeed—or perhaps not?

The real issue is whether or not AI data centers are economically viable, socially appropriate, environmentally sustainable, and actually serve the public interest.

In August 2025, ProPublica reported that the Food and Drug Administration (FDA) had lost 20% of its staff devoted to food safety thanks to DOGE cuts. Inspection of food import facilities is now at a historic low even as our dependence on the rest of the world to feed us grows. But not to worry, the FDA announced in May that AI was coming to the rescue thanks to a large language model (LLM)—dubbed Elsa—that would be deployed alongside what’s left of its human staff to expedite their oversight work. Hopefully, Elsa knows melamine when it sees it. AI chatbots are also growing in popularity and available 24-7 to “talk or advise” people on all sorts of pressing issues—how to win more friends, how to cheat on this exam, how to make up fake legal opinions, even encouraging a teenager to commit suicide and suggesting to someone else that they murder their own parents.

But there is an even dirtier AI underbelly. Some have dubbed these AI slop, AI smut, and AI stazi—three 21st-century horsemen of the digital apocalypse. What is this all about? Well, a lot of these accelerating AI algorithms are actually devoted to selling “products” that many people do not want and would find objectionable, as well as providing “services” that undermine our basic freedoms. Slop (Merriam Webster’s word of 2025) is used to describe when AI generates internet content that is only meant to make money through advertising. Right now there are thousands of wannabe internet “creatives” all over the globe, watching “how-to videos” to manufacture AI social media to grab the eyeballs of US consumers. That cute puppy video you see on Instagram or that shocking “news” story you read on Facebook is not by accident—the goal is to monetize clicks per thousand (cost per mille, or CPM) where advertisers pay for how much their ad is viewed online. This is also why online content is often overly long (where is the actual recipe in this cooking blog?), since that increases ad scrolling. The average US consumer is now subject to between 6,000 and 10,000 ads per day—70% of which are online. For more on AI slop, visit: https://www.visibrain.com/blog/ai-slop-social-media.

An even worse virtual commodity is AI smut—literally algorithms creating pornography. This perverted version of AI scraps the internet for images (high school yearbooks, red carpet fashion shows, popular music concerts, street cam footage, etc.) and then uses “face swap” programs to create personalized hardcore rubbish. There is little if any accountability for this theft of public images and violation of personal privacy—at best those involved are “shamed” into taking down their AI sites after being exposed due to fears of liability and prosecution for child abuse. But that has hardly stopped this seedy AI subsector. Can you imagine your face or image being put into such a lucrative sexploitative scenario without your permission? At this point, there are hardly any internet police walking the beat in the virtual AI world. We don’t even have the right to be forgotten on the internet.

Which brings us to AI stazi—the updated version of the Cold War-era East German secret police. University of Wisconsin Madison just announced the creation of a College of Computing and Artificial Intelligence (CAI), in part thanks to a $140 million donation from Cisco. Few Bucky Badger fans know that 30 years ago they were used as guinea pigs while cheering at Camp Randall Stadium to help create facial recognition technology through a UW-Madison grant from the Department of Defense Applied Research Agency (DARPA). Visitors to the UW campus today will no doubt “enjoy” the automated license plate readers (ALRPs) owned by Flock Safety. According to an August 2025 Wisconsin Examiner expose, there are hundreds of Flock cameras across the state in use by law enforcement agencies, including Wisconsin county sheriff departments with active 287(g) cooperation agreements with Immigration and Customs Enforcement. No warrant is needed for law enforcement agencies to browse the national Flock database. In fact, agents have used Flock to track peaceful protesters, spy on spouses, or just stalk people they don’t like. To see where Flock cameras are near you, visit: www.deflock.me. Of course, Flock Security has outsourced its AI programming to cheaper (and more secure?) Filipino contractors. Similar AI spying networks such as Pegasus have been widely exposed and have become “bread and butter” for authoritarian regimes from Israel to Saudi Arabia. China and Russia have their own versions (Skynet, SORM, etc.). Thanks to the cozy relationship between Trump and Peter Thiel, the US-based AI mercenary outfit, Palantir, is now being redeployed for domestic surveillance—first revealed by Edward Snowden back in 2017.

The latest executive bluster from Trump is that states’ rights are out the window when it comes to regulating AI data centers—such federal preemption of local democratic control is part of the larger neoliberal “race to the bottom” forced-trade agenda. But the cat is already out of the bag as dozens of communities have successfully blocked AI data center projects and others are poised to do the same based upon their winning strategies. Better yet, this is a bipartisan grassroots organizing issue!

What is the best way to keep out an AI factory farm? No non-disclosure agreements (NDAs)! These are massive development schemes that could not exist without the approval and support of elected officials, so any agreement should not be secret. They can hardly claim to be providing a public good if they are not subject to transparency and oversight. No sweetheart deals! Big Data is among the wealthiest sectors of our current economy and does not need or deserve subsidies, discounted electric rates, tax increment financing, property tax holidays, or other incentives. It is a classic move of crony capitalism to privatize the benefits and socialize the costs. No regulatory loopholes! Given their huge demands for land, water, and energy, Big Data should not be allowed to cut legal corners and needs to follow all the rules of any other normal enterprise—full liability coverage, no special economic zones, consideration of cumulative impacts, protections for ratepayers, no unregulated toxic pollution or illegal water transfer in violation of the Clean Water Act or the Great Lakes Compact, etc. How much water your data center demands is hardly a “trade secret.”

And most important, don’t let Big Data boosters belittle your legitimate concerns as “neo-Luddite!” Everyone uses technology—even the Amish. The real issue is whether or not AI data centers are economically viable, socially appropriate, environmentally sustainable, and actually serve the public interest. People have good reasons to be wary and oppose them on all those fronts.

For more info, checkout: Big Tech Unchecked: A Toolkit for Community Action

As well as the North Star Data Center Policy Toolkit


Our work is licensed under Creative Commons (CC BY-NC-ND 3.0). Feel free to republish and share widely.


John Peck
John E. Peck is the executive director of Family Farm Defenders.

Sunday, January 11, 2026

 

Forest biomass becomes surprise carbon hero—if industry can cut costs and scale up



Chemicals and long-lived timber could deliver up to 750 Gt CO₂ removal by 2050



Journal of Bioresources and Bioproducts

Forest Biomass Becomes Surprise Carbon Hero—If Industry Can Cut Costs and Scale Up 

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In the first quantitative roadmap covering the entire forest-biomass value chain, researchers show that integrating selective harvesting, residue valorisation and advanced catalytic refining could raise carbon-use efficiency above 85 % and generate an annual mitigation wedge of 2.2 Gt CO₂—comparable to eliminating global aviation emissions twice over. The study, published today in Journal of Bioresources and Bioproducts, pinpoints lignin recalcitrance and volatile bio-chemical prices as the twin barriers preventing the sector from moving from pilot glory to gigatonne scale, and calls for an international “carbon-smart biorefinery” programme modelled on semiconductor R&D alliances.

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Credit: Key Laboratory of Songliao Aquatic Environment, Ministry of Education, Jilin Jianzhu University, Changchun 130118





The next time you buy a wooden table or burn a wood pellet, you may unwittingly be part of the largest untapped carbon-removal experiment on Earth. A data-rich review released 31 December in Journal of Bioresources and Bioproducts argues that forest biological resources—everything from sawdust to resin—could offset up to 750 gigatonnes of CO₂ by mid-century if processing efficiency rises and green premiums fall.
Drawing on 200 peer-reviewed studies and FAO trade statistics, the paper tracks carbon from nursery to nail. Photosynthesis already pulls roughly 20 t CO₂ per hectare from the atmosphere in fast-growing poplar plantations; the trick is keeping that carbon locked in society rather than returning it via slash burning or short-lived paper towels. The authors calculate that engineered beams can store carbon for 50–100 years, biochar for centuries, while bioethanol distilled from logging slash offers a 74 % lifecycle GHG cut versus gasoline.
Yet the economic maths is brutal. Lignocellulose-to-ethanol plants yield only 40–55 % of theoretical output, and advanced bio-based chemicals sell for 1.3–3.0 times the price of their petro-counterparts. “We are paying Porsche prices for a technology that still behaves like a hand-built car,” said lead author Yingying Xu.
The review sketches a two-stage escape route. By 2030, hybrid organosolv-steam explosion pretreatments and two-step catalysis could push furfural and ethanol yields above 70 % while trimming capital costs 25 %. Longer term, AI-driven biorefineries that co-produce aviation fuel, lignin-based graphene and renewable natural gas could turn wood into a “dynamic carbon-regulation asset” whose output flexes with real-time grid intensity and carbon prices.
Geography matters. North America and Europe together control 54 % of global industrial round-wood but face saturated paper markets; Asia, led by China, already imports 8 % of world supply and could become the test-bed for residue-based refining. Finland’s national heating network gets 39 % of its energy from wood pellets, proving district-scale viability, while China’s 9-million-hectare afforestation reserve could anchor a 170-million-tonne bioproduct stream under selective-logging rules.
Policy, however, remains fragmented. Only 30 % of countries apply uniform carbon-accounting rules for harvested wood products, and subsidy schemes oscillate with oil prices. The paper urges governments to embed forest biorefineries in upcoming carbon-trading clauses, offer reverse auctions for negative emissions, and standardise life-cycle metrics so that a tonne of CO₂ removed in Sweden can be compared with one stored in a Canadian 2×4.
Without such moves, the climate opportunity is “a warehouse full of timber with no buyer,” the authors warn. Scale up the technology, stabilise demand, and forests could supply one-third of the cumulative CO₂ removals needed for 1.5 °C—while keeping the planet both housed and heated.

Thursday, January 08, 2026

  

Sub-iethal water disinfection may accelerate the spread of antibiotic resistance




Maximum Academic Press





The study reveals that environmental stressors do not merely kill bacteria; they can also prime surviving cells to take up resistance genes more efficiently, raising concerns about how antibiotic-resistant bacteria may spread in aquatic environments.

Antibiotic resistance genes and antibiotic-resistant bacteria are now recognized as emerging environmental contaminants, widely detected in rivers, lakes, wastewater, and even oceans. Aquatic systems provide ideal conditions for resistance genes to persist, interact, and spread among microorganisms. Bacteria exchange genetic material through horizontal gene transfer, including transformation, a process in which cells directly absorb free DNA from their surroundings. While transformation is known to contribute to resistance dissemination, its behavior under realistic environmental stress—such as incomplete disinfection—has remained poorly understood. Modern water treatment increasingly relies on advanced oxidation and light-based technologies, yet fluctuations in treatment efficiency can leave bacteria alive but stressed rather than fully inactivated. Understanding how these sub-lethal conditions influence ARG transfer is critical for public health protection.

study (DOI:10.48130/biocontam-0025-0017) published in Biocontaminant on 08 December 2025 by Taicheng An’s team, Guangdong University of Technology, reveals that sub-lethal water disinfection can unintentionally accelerate the spread of antibiotic resistance by promoting stress-induced uptake of resistance genes in surviving bacteria.

Using a sub-lethal photocatalysis (sub-PC) system to simulate incomplete water disinfection, this study systematically evaluated how oxidative stress influences the transformation of ARGs. Two antibiotic-sensitive recipient strains, Escherichia coli DH5α and E. coli HB101, were exposed to sub-PC conditions and assessed for bacterial inactivation, physiological stress responses, and ARG uptake using a plasmid carrying the ampicillin resistance gene (amp). Under identical sub-PC exposure, bacterial abundances declined gradually by approximately 2 log after 120 min, yet nearly 10% of cells remained viable, providing a sufficient pool for horizontal gene transfer via transformation. Correspondingly, intracellular reactive oxygen species (ROS) levels increased markedly during the early phase (0–60 min), reaching three- to fourfold higher than baseline, while antioxidant enzymes catalase (CAT) and superoxide dismutase (SOD) were strongly induced, indicating activation of oxidative stress defenses. As treatment progressed, excessive damage led to declining ROS, CAT, and SOD levels, consistent with cell lysis and leakage. Following plasmid uptake, ampicillin-resistant transformants exhibited enhanced persistence under sub-PC, showing only a ~1 log reduction in abundance, supporting the notion that ARG acquisition improves stress tolerance. Optimization experiments revealed that transformation was most efficient at 37 °C and required high recipient densities; maximal transformant yields occurred at 10⁸–10⁹ CFU·mL⁻¹, with 10⁸ CFU·mL⁻¹ selected for robust quantification. Under these optimal conditions, transformation frequencies increased three- to four-and-a-half-fold, peaking at 50–60 min before declining as cellular damage accumulated. Mechanistic analyses showed that ROS scavengers significantly weakened, but did not abolish, the enhancement effect, confirming ROS as a key driver. Sub-PC also increased membrane permeability, elevated intracellular Ca²⁺ nearly fourfold, and depleted ATP, limiting Ca²⁺ efflux and reinforcing its accumulation. Gene expression profiling corroborated these trends, showing early upregulation of stress response, antioxidant, membrane transport, and DNA uptake genes, alongside repression of energy metabolism pathways.

The findings highlight a critical but underappreciated risk in water treatment systems: partially effective disinfection may promote, rather than prevent, the spread of antibiotic resistance. Sub-lethal stress not only allows bacteria to survive but actively enhances their capacity to acquire resistance genes from the environment. This mechanism could contribute to the persistence and amplification of antibiotic resistance in wastewater effluents, surface waters, and downstream ecosystems.

###

References

DOI

10.48130/biocontam-0025-0017

Original Source URL

https://doi.org/10.48130/biocontam-0025-0017

Funding information

This work was supported by NSFC (42330702 and 42077333), and the Introduction Innovative and Research Teams Project of Guangdong Pearl River Talents Program (2023ZT10L102).

About Biocontaminant

Biocontaminant is a multidisciplinary platform dedicated to advancing fundamental and applied research on biological contaminants across diverse environments and systems. The journal serves as an innovative, efficient, and professional forum for global researchers to disseminate findings in this rapidly evolving field.

Ushikuvirus: A newly discovered giant virus may offer clues to the origin of life


Ushikuvirus, an amoeba-infecting giant virus, joins the family of giant viruses that may have driven the evolution of complex cells



Tokyo University of Science

Ushikuvirus: A newly discovered giant virus may offer clues to the evolutionary relationships 

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Researchers discover a new virus called the “ushikuvirus” that provide evidence for the viral eukaryogenesis hypothesis and reveal virus–host interactions, shaping the evolution of eukaryotic cells.

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Credit: Professor Masaharu Takemura from Tokyo University of Science, Japan





The origin of life on Earth becomes even more fascinating and complex as we peer into the mysterious world of viruses. Said to have existed since living cells first appeared, these microscopic entities differ greatly from other forms of life. Composed of only genetic material, they lack the ability to synthesize proteins, which are essential for carrying out cellular activity and, ultimately, for life by itself.

As a result, scientists have long sought to unravel virus origins, how they evolve, and how they fit into the conventional tree of life. Professor Masaharu Takemura from the Graduate School of Science, Tokyo University of Science (TUS), Japan, has been at the forefront of this search. In 2001, he, along with Dr. Philip Bell, from the Department of Biological Sciences, Macquarie University, Sydney, independently proposed the cell nuclear virus origin theory, also known as viral eukaryogenesis (term coined by Dr. Bell). According to this hypothesis, the nucleus of eukaryotic cells (cells whose nucleus is bound by a membrane) originated from a large DNA virus such as poxvirus that infected an archaeal ancestor (single-celled microorganisms). Instead of killing the host, the virus set up a long-term presence inside the cytoplasm, and over time acquired essential genes from the host, and became what we now recognize as the nucleus of eukaryotic cells. This suggests that viruses may have played a foundational role in the emergence of life.

Nowadays, central to this idea are giant viruses that contain DNA, which were found in 2003. When they infect cells, they form specialized structures called virus factories inside the host. Some of these factories are enclosed within a membrane, much like a cell nucleus, where DNA replication takes place, hinting at an evolutionary connection between viruses and complex cells.

In recent years, new types of DNA viruses have been discovered, including members of the family Mamonoviridae, which infect acanthamoeba (a type of amoeba, which is a single-celled microorganism), and the closely related clandestinovirus, which infects vermamoeba (another type of amoeba from a different family).

Now, in a joint study published online in the Journal of Virology on November 24, 2025, Prof. Takemura along with researchers at the National Institute of Natural Sciences (NINS), Japan, report yet another of these giant DNA viruses that infect amoeba. Named ushikuvirus after Lake Ushiku in the Ibaraki Prefecture of Japan, where it was isolated. This discovery offers further support for the nuclear virus origin hypothesis.

The team included Mr. Jiwan Bae and Mrs. Narumi Hantori, Master’s degree students at the Graduate School of Science, TUS, along with Dr. Raymond Burton-Smith and Professor Kazuyoshi Murata from NINS.

“Giant viruses can be said to be a treasure trove whose world has yet to be fully understood. One of the future possibilities of this research is to provide humanity with a new view that connects the world of living organisms with the world of viruses,” says Prof. Takemura.

Giant viruses are ubiquitously present in the environment. However, their isolation remains a challenge. These viruses are highly diverse and the discovery of ushikuvirus is extremely valuable. The newly discovered ushikuvirus infects vermamoeba, like clandestinovirus, and is morphologically similar to members of the Mamonoviridae family, particularly Medusavirus, a genus characterized by its icosahedral shape and numerous short spikes on the capsid surface. However, ushikuvirus also shows distinct features: it induces a specific cytopathic effect that causes its vermamoeba hosts to grow into unusually large cells, and it possesses multiple spike structures with unique caps on the capsid surface, some with filamentous extensions, not seen in medusaviruses.

Additionally, unlike medusaviruses and clandestinovirus, which replicate within the intact host nucleus, ushikuvirus disrupts the nuclear membrane to produce viral particles. This suggests a phylogenetic link between Mamonoviridae family that utilizes intact nucleus as viral factory and giant viruses like pandoravirus that disrupt the nuclear membrane for replication. Researchers believe that these variations between viruses may have evolved as adaptations to their hosts.

By comparing these structural and functional differences, researchers are beginning to piece together how giant viruses have diversified over time and how their interactions with host cells may have shaped the evolution of complex eukaryotic life. 

“The discovery of a new Mamonoviridae-related virus, ‘ushikuvirus,’ which has a different host, is expected to increase knowledge and stimulate discussion regarding the evolution and phylogeny of the Mamonoviridae family.  As a result, it is believed that we will be able to get closer to the mysteries of the evolution of eukaryotic organisms and the mysteries of giant viruses,” says Prof. Takemura.

The discovery of these amoeba-infecting viruses could have practical implications for healthcare. Because certain Acanthamoeba species can cause diseases such as amoebic encephalitis, understanding how giant viruses infect and destroy amoebae may one day help scientists develop new strategies to prevent or treat such infections.

 

***

 

Reference                     
DOI: 10.1128/jvi.01206-25

 

About The Tokyo University of Science
Tokyo University of Science (TUS) is a well-known and respected university, and the largest science-specialized private research university in Japan, with four campuses in central Tokyo and its suburbs and in Hokkaido. Established in 1881, the university has continually contributed to Japan's development in science through inculcating the love for science in researchers, technicians, and educators.

With a mission of “Creating science and technology for the harmonious development of nature, human beings, and society," TUS has undertaken a wide range of research from basic to applied science. TUS has embraced a multidisciplinary approach to research and undertaken intensive study in some of today's most vital fields. TUS is a meritocracy where the best in science is recognized and nurtured. It is the only private university in Japan that has produced a Nobel Prize winner and the only private university in Asia to produce Nobel Prize winners within the natural sciences field.

Website: https://www.tus.ac.jp/en/mediarelations/

 

About Professor Masaharu Takemura from Tokyo University of Science
Dr. Masaharu Takemura is a Professor in the Department of Mathematics and Science Education, Graduate School of Science at the Tokyo University of Science, Japan. His research interests include giant virus biology, viral eukaryogenesis, and virus education. Over his career, he has published more than 120 papers, amassing over 2,500 citations for his work. His research goal is to elucidate the evolution of giant viruses and eukaryotes and develop teaching materials for virus education.

 

Funding information
This research was supported by JSPS/KAKENHI grant number 20H03078 and Joint Research of the Exploratory Research Center on Life and Living Systems (ExCELLS) (ExCELLS program No, 22EXC601-4).