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Monday, October 28, 2024

AMERIKA
‘Expect war’: leaked chats reveal influence of rightwing media on militia group

Jason Wilson
THE GUARDIAN
Mon 28 October 2024

A man in Washington DC holds leaflets falsely claiming that Trump won the 2020 presidential election, in November 2020.Photograph: NurPhoto/Getty Images

Leaked and public chats from Arizona-based “poll watching” activists aligned with a far-right militia group show how their election paranoia has been fueled by a steady drumbeat of conspiracy theories and disinformation from rightwing media outlets and influencers, including Elon Musk.

The materials come from two overlapping election-denial groups whose activists are mostly based in Arizona, one of seven key swing states that will decide the US election and possibly end up at the center of any disputed results in the post-election period.

Chat records from a public-facing channel for the America First Polling Project (AFPP) were made available to reporters by transparency group Distributed Denial of Secrets (DDOSecrets). The activist who leaked those materials to DDOSecrets provided the Guardian directly with an archive of the Arizona 2022 Mid-Term Election Watch (A22) chat channel.


Related: The far-right megadonor pouring over $10m into the US election to defeat ‘the woke regime’

The materials offer a window into the way in which the rightwing information environment – and the unverified, distorted or false information it proffers – erode faith in elections, and encourage those who would violently disrupt them.
From the media to far-right conspiracy

The materials underline previously reported links between poll watching groups and the American Patriots Three Percent (AP3) militia, such that the militia provided “paramilitary heft to ballot box monitoring operations”.

At least half a dozen pseudonymous activist accounts are present across all of the chats, and early posts in the AFPP chat show activists at “tailgate parties” that brought together election denial groups and militia members ahead of the 2022 midterms election.

They also show the broad cooperative effort among a range of election denial groups, whose activities were fueled by disinformation from high-profile conservative activists.

On 6 October 2022, in one of the first archived messages on the semi-private A22 chat, a user with the same name as the channel (Arizona 2022 Mid-Term Election Watch) announced to the group that they had “heard back from the cleanelectionsusa.org so I might try to coordinate between the two efforts”. They added: “In any case I will schedule a couple of zoom calls so we can connect.”

Two days later, the same account updated: “There are 13 drop box only locations in Maricopa county of which only 2 are 24 hour locations,” adding: “We will need help with getting these watched. I have also been able to connect with cleanelectionsusa and am coordinating with those folks.”

Clean Elections USA, founded by Oklahoman Melody Jennings, is one of a number of election denial groups that sprang up in the wake of the 2020 election, after Trump and his allies mounted a campaign to reverse that year’s election result on the basis of false claims that the vote was stolen.

During the 2022 election season, the organization was slapped with a restraining order over its ballot monitoring – some of it carried out by armed activists – that the federal Department of Justice described in its filing as “vigilante ballot security efforts” that may have violated the Voting Rights Act. That lawsuit was settled in 2023.

The organization’s website has shuttered; however, archived snapshots indicate that the organizers were motivated by discredited information from long-running election denial organization True the Vote and 2000 Mules, the title of a conspiracy-minded book and accompanying documentary by rightwing provocateur Dinesh D’Souza.

The book and film repeated True the Vote’s allegations that paid “mules” had carried illegal ballots to drop boxes in swing states in 2020. D’Souza’s publisher in June withdrew the book and film from distribution and apologized to a man whom D’Souza falsely accused of criminal election fraud.

The “mules” falsehoods were treated as baseline reality in the A22 chat. On 9 November, a user named “trooper” sought to account for Republicans’ unexpectedly poor showing with the claim “275k drop-off ballots – meaning the mules flooded the system on election day while the disaster distraction was in play”, adding that “they swarmed the election day drop boxes like fucking locusts”.

The pro-democracy Bridging Divides Initiative (BDI) at Princeton University recently published research indicating elevated worries about harassment on the part of local officials, including election officials. BDI’s research backed up findings from the Brennan Center indicating that 70% of election officials said that threats had increased in 2024, and 38% had personally experienced threats, up from 30% last year.

Shannon Hiller, BDI’s executive director, said: “We continue to face elevated threats and risk to local officials across the board,” however in 2024, “there’s been a lot more preparation and there’s a clearer understanding about how to address those threats now.”

Heidi Beirich, co-founder of the Global Project Against Hate and Extremism (GPAHE) said that talk of election fraud using drop boxes had returned in 2024. “I can’t think of an election-denying organization, whether it’s Mike Lindell, True the Vote, or more local outfits in various states that aren’t talking about patrolling drop boxes and watching voters while they’re voting”, she said.
From disinformation to violent threats

Beirich’s warnings are reflected in ongoing AFPP Telegram chats, where any prospect of a Harris victory is met with conspiracy theories, apocalyptic narratives, and sometimes threats.

The Guardian’s review of the materials found many instances in which disinformation or exaggerated claims in the media or from rightwing public figures led directly to violent rhetoric from members of the chat.

On 13 March, a user linked to a story in the Federalist which uncritically covered a claim by the Mississippi secretary of state, Michael Watson, that the Department of Justice was “using taxpayer dollars to have jails and the US Marshals Service encourage incarcerated felons and noncitizens to register to vote” on the basis of Biden’s March 2021 executive order aimed at expanding access to voting.

A user, “@Wilbo17AZ”, replied: “If we don’t fight this with our every waking breath, we are done. Expect war.”

On 24 June, a user posted an article from conspiracy-minded, Falun Gong-linked news website Epoch Times, which reported on the supreme court’s rejection of appeals from a Robert F Kennedy-founded anti-vaccine non-profit,

The court declined to hear the appeals over lower court’s determinations that the non-profit had no standing to sue the Food and Drug Administration over its emergency authorization of Covid-19 vaccines during the pandemic.

In response, another user, “cybercav”, wrote: “I do not see any path forward for our Republic that doesn’t include ‘Purge and Eradicate’ being the general orders for both sides of the next civil war.”

In January, the @AFPP_US account posted a link to an opinion column on the Gateway Pundit by conspiracy theorist Wayne Allyn Root. Root characterized cross-border immigration as an invasion in the piece, and concluded by telling readers to “Pray to God. Pray for a miracle. Pray for the election in November of President Donald J Trump.”
Fueling paranoia

Over the summer, overseas events fueled the paranoia of chat members.

On 6 August the @AFPP_US account posted a link to Guardian reporting on anti-immigrant riots that took place in the UK over the summer.

The article described the riots as “far-right violence”; @AFPP_US captioned the link “‘Far Right’ = ‘Stop raping women and stabbing children’”.

The next day, the same account apparently attempted to link the riots to UK gun laws, which are more restrictive than the US.

The stimulus was a story on the riots by conspiracy broadcaster Owen Shroyer, an employee of Alex Jones who was sentenced to two months in prison for entering a restricted area at the US Capitol on 6 January 2021.

@AFPP_US wrote: “UK is a failed state and possession of the Calaphite [sic]. The imperialists have become the Imperiled. This is what just a few generations of disarmament and pussification hath wrought.”

One major vector of bad information in the A22 chats is the Gateway Pundit, a pro-Maga website operated by Jim Hoft. That website has been a noted source of election disinformation for years. Earlier this month Hoft’s organization settled a defamation suit with two election workers that it had falsely accused of election fraud. Accountability non-profit Advance Democracy Inc reported in August that in the first nine months of 2024 Hoft had published at least 128 articles referencing election fraud and election workers.

Gateway Pundit articles were shared many times in the chat.

On 21 January, the @AFPP_US account shared a Gateway Pundit story by Hoft in which he claimed that liberal philanthropist and chair of the Open Society Foundation, Alexander Soros, had posted a coded message advocating the assassination of a re-elected President Trump.

The basis was that Soros’s post carried a picture of a bullet hole and a hand holding $47. But those pictures came from a story in the Atlantic, about falling crime rates, that Soros was linking to in the post.
‘Millions of illegals’

On at least one occasion, the Gateway Pundit was quoted in the group because it was amplifying the claims of another major source of disinformation for A22: Elon Musk.

The Gateway Pundit article posted to the chat in January was titled “JUST IN … Elon Musk Rips Mark Zuckerberg for Funding Illegal Voting Vans in 2020 Election”. It highlighted Musk’s false claim that Zuckerberg’s funding of county-level voting apparatuses in 2020 was illegal.

As elections approached, AFPP members added more of Musk’s pronouncements into the stew of disinformation on the site, with a particular emphasis on anti-immigrant material.

On 7 September, as rightwing actors stoked panic about Haitian immigrants, @AFPP_US posted a link to a Musk post quote-posting a video of Harris addressing the need to support Haitian migrants with the comment: “Vote for Kamala if you want this to happen to your neighborhood!”

On 29 September, the AFPP lead account linked to a Musk post that claimed “Millions of illegals being provided by the government with money for housing using your tax dollars is a major part of what’s driving up costs”.

On 1 October, the @AFPP_US account shared an X post in which Musk asserted that “if Trump is NOT elected, this will be the last election”, and wove that claim into a narrative resembling the “great replacement” conspiracy theory, claiming that “Democrats are expediting” the conversion of “illegals” to citizens in an attempt to make America a “one-party state”.

The Guardian reported in 2021 that a separate AP3 website leak, which exposed the paramilitary organization’s membership list, showed that at that time members included serving military and law enforcement officers.

In August, ProPublica reported on an earlier leak of AP3 materials from the same source, showing that AP3 had carried out vigilante operations on the Texas border, and had forged close ties with law enforcement officers around the country.

Beirich said that chatter monitored by the organization has obsessively focused on the narrative of illegal immigrants voting in a “rigged” election. “Non-citizens voting is the big fraud that they’re talking up,” she said.

Earlier this month, Wired reported that the current leak showed evidence of plans to carry out operations “coordinated with election denial groups as part of a plan to conduct paramilitary surveillance of ballot boxes during the midterm elections in 2022”.

Wednesday, September 18, 2024

 

US confirms release of American pastor David Lin from China prison
US confirms release of American pastor David Lin from China prison

The US State Department confirmed in a press conference on Monday that David Lin, an American pastor the US alleges was wrongfully detained since 2009, has been released. US State Department Spokesperson Matthew Miller stated that Lin returned to the US for the first time in almost 20 years after he was released from prison in China.

Lin’s release comes after Jake Sullivan, the current US State representative, wrapped up a three-day trip to Beijing, China to meet with top Beijing officials. While Miller did not confirm if the release was a result of negotiations during the trip, he stated that the US Secretary raised David Lin’s case whenever he met with Chinese officials. Miller also said that the US State Department would “continue to push for the release of other Americans.”

Lin was originally arrested in 2009 after he attempted to create a Christian training center in Beijing, where he was then arrested and sentenced to life on the charge of “contract fraud”. According to rights organization Dui Hua Foundation, contract fraud charges are “frequently used against Church house leaders who raise funds to support their work”. The foundation previously wrote:

Dui Hua found that the 1997 revision to the criminal law placed “cult” trials into the purview of district courts, resulting in less transparency and attention [to] such cases. By 1999, trials of Article 300 cases—for those accused of organizing and using superstitious sects, secret societies [] and religious organizations to undermine the law—soared, largely due to the ban on Falun Gong.

Friday, September 13, 2024

How the humble capybara became a spirit animal for Asia's youth

By Iris Zhao and Jenny Cai
ABC.NET.AU


Li Jing said she fell in love with capybaras for their relaxed and friendly temperament. (Supplied)
abc.net.au/news/how-capybaras-became-asia-s-spirit-animal/104335784Link copied
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After years of following them online, Li Jing finally met her spirit animal – the capybara — at Sydney's Taronga Zoo.

"I first fell in love with capybaras when I saw their videos online. They were taking a bath in a Japanese zoo," Ms Li said.

The 31-year-old, who works in the pet industry, said she adored them because they were "so cute, so quiet, and so chill".

@fierceanimalss

Capybara🤣 #capybara #capibara #funnyanimals #animalesgraciosos #capybaratiktok♬ Capybara - Сто-Личный Она-Нас & Betsy

"When I realised Taronga Zoo had them, I got really excited and immediately went to see them.

"Only four people can interact with the capybaras every day. People were lining up half an hour before tickets started to sell.

"Luckily, we got in. I fed them bamboo and they are just as cute as they are on video!"

The rodent species is a herbivore and can be found across most of South America, living in both wetlands and forests.

Semi-aquatic, they live partly on land and partly in water.

And they've won hearts all across the world in recent years.

Their rise to global stardom started in 2023, when a Russian blogger released a song called Capybara that went viral on TikTok and received millions of likes.

In parts of Asia, the animal's popularity took off years earlier, with an active fandom developing in Japan in the early 2010s, followed by China.

There are many cute animals around, but there is something special about capybaras, according to Ms Li.

"They have the vibe of being able face everything with a relaxed attitude … walking slowly, eating slowly and standing very still.

"They are also so friendly and can live harmoniously with other animals without conflict.


"Many people nowadays feel a lot of anxiety, and these qualities of capybaras are healing and release the pressure."

How did capybaras become Asia's favourite rodent?

A spiritual totem in a post-pandemic world

Like Ms Li, many young people on social media are increasingly using capybara content as a form of self-expression.

Its emojis are widely used and translated into different languages.

And in China, an online community of capybara lovers have identified themselves with the phrase "túnmén", which carries the connotation of piously following the capybara way of life as if it were a religious teaching.

Qian Gong, a researcher of Chinese popular culture at Curtin University, said the "highly volatile and super competitive" environment of the post-COVID era was one reason why the animal had become so popular among young people in Asia.

"Capybaras seem to be favoured particularly for their temperament — emotionally stable and having a calm attitude," Dr Gong said.

"Young people have been struggling to cope with pressure and many could not see the point of trying hard and joining the rat race.



A capybara in a hot spring at a zoo in Ito, Japan. (Reuters: Sakura Murakami )

Dr Gong added that internet neologisms like "lying-flat" and "quiet quitting" reflects the same kind of sentiment — but in comparison, a capybara's temperament carried a more positive connotation than these terms.

The idea of "lying flat" refers to working just enough to get by in China.

And instead of the rat race, it turns out young people have embraced a very different rodent.


"The capybara's personality is described by fans as 'buddha-like', suggesting a desire to seek peacefulness and tranquillity," Dr Gong explained.
The rise of a 'capybara economy'


The online popularity of capybara has created business opportunities as well. (ABC News: Iris Zhao )

Beyond the internet craze, capybaras have also found their way into people's lives and created new business opportunities.

Pinyu Chen is the manager of a capybara-themed cafe called Mogu Kabi in the Taiwanese city of Tainan.

It opened in January 2022 and is home to five of the animals.

"At the time, capybaras weren't as popular in Taiwan as they were in Japan," Ms Chen said.

"We started doing this after seeing them on a Japanese tourist show. We imported baby capybaras from the United States.


"But today, almost every city has a capybara farm."



Capybaras at the Mogu Kabi cafe in Taiwan are adored by locals and tourists from around the world. (Supplied: Mogu Kabi)

According to Ms Chen, the cafe immediately became popular, attracting customers from all over the world.

"We are really surprised about the level of enthusiasm people have for capybaras."

But, she said, capybaras have a "timid and sensitive nature", so are often nervous around strangers.

"Therefore we limit the number of customers allowed to interact with them."

Fans have sometimes lined up at the cafe for more than two hours just to get a chance to see them.

Capybara-themed merchandise can also be found almost anywhere in Asia in the form of soft toys, key chains, backpacks and blankets.

These kind of products have been relatively rare in Australia, but recently a variety of capybara toys made their debut in several Melbourne stores.


Polly Zeng is the owner of a store that sells capybara toys in Melbourne.
 (ABC News: Iris Zhao)

Shop owner Polly Zeng, 28, said her capybara products sold out in under three weeks.

"I brought them here because I personally really love capybaras," she said.

"I had no idea whether they would appeal to Australian consumers.


"It turns out that they sell so well.

"The younger generations are more focused on their own wellbeing and want to reject overthinking."
Animal rights concerns

The popularity of capybaras has prompted some people overseas to keep them as household pets.

However, many owners have lacked the necessary expertise in caring for them, prompting animal welfare concerns from advocates.

Under federal and state law it is illegal to have a capybara as a pet in Australia. Whereas it is legal in some parts of Asia.

Huang Yuan, a vet from China's central city of Wuhan, said he once treated a capybara which was found abandoned.



What kind of dog is this?🤣 pic.twitter.com/hn3Ibwk3gJ— Nature is Amazing ☘️ (@AMAZlNGNATURE) July 22, 2024


"A zookeeper sent [the animal] to me and told me it was rescued by a resident," he said.

"The capybara got septicaemia. It stopped eating and its stomach bloated.

"It died soon after the surgery," the vet added.

Ms Chen said although many of her cafe's patrons had expressed the desire to have a pet capybara, it wouldn't be right for the welfare of these tranquil animals.

"It is an aquatic animal, it likes to play with water," she explained.

"You also need to have at least two capybaras at a time, because they are social."

Therefore, she said, they are "not suited for the conventional home environment".



Capybaras are particularly adored for their calm temperament. 
 ( Reuters: Sakura Murakami)

Ms Li shared a similar sentiment.

"The better way is to watch them at a distance, rather than getting too close," she said.


"We need to try our best to create the environment that can maximise their happiness.

"I will just go to Taronga Zoo to see them once in a while."

Wednesday, August 21, 2024

Digital Apartheid in Gaza: Big Tech Must Reveal Their Roles in Tech Used in Human Rights Abuses
August 18, 2024
Source: EFF


Image via EFF



This is part two of an ongoing series. Part one on unjust content moderation is here.

Since the start of the Israeli military response to Hamas’ deadly October 7 attack, U.S.-based companies like Google and Amazon have been under pressure to reveal more about the services they provide and the nature of their relationships with the Israeli forces engaging in the military response.

We agree. Without greater transparency, the public cannot tell whether these companies are complying with human rights standards—both those set by the United Nations and those they have publicly set for themselves. We know that this conflict has resulted in alleged war crimes and has involved massive, ongoing surveillance of civilians and refugees living under what international law recognizes as an illegal occupation. That kind of surveillance requires significant technical support and it seems unlikely that it could occur without any ongoing involvement by the companies providing the platforms.

Google’s Human Rights statement claims that “In everything we do, including launching new products and expanding our operations around the globe, we are guided by internationally recognized human rights standards. We are committed to respecting the rights enshrined in the Universal Declaration of Human Rights and its implementing treaties, as well as upholding the standards established in the United Nations Guiding Principles on Business and Human Rights (UNGPs) and in the Global Network Initiative Principles (GNI Principles). Google goes further in the case of AI technologies, promising not to design or deploy AI in technologies that are likely to facilitate injuries to people, gather or use information for surveillance or be used in violation of human rights, or even where the use is likely to cause overall harm.”

Amazon states that it is “Guided by the United Nations Guiding Principles on Business and Human Rights,” and that their “approach on human rights is informed by international standards; we respect and support the Core Conventions of the International Labour Organization (ILO), the ILO Declaration on Fundamental Principles and Rights at Work, and the UN Universal Declaration of Human Rights.”

It is time for Google and Amazon to tell the truth about use of their technologies in Gaza so that everyone can see whether their human rights commitments were real or simply empty promises.
Concerns about Google and Amazon Facilitating Human Rights Abuses

The Israeli government has long procured surveillance technologies from corporations based in the United States. Most recently, an investigation in August by +972 and Local Call revealed that the Israeli military has been storing intelligence information on Amazon’s Web Services (AWS) cloud after the scale of data collected through mass surveillance on Palestinians in Gaza was too large for military servers alone. The same article reported that the commander of Israel’s Center of Computing and Information Systems unit—responsible for providing data processing for the military—confirmed in an address to military and industry personnel that the Israeli army had been using cloud storage and AI services provided by civilian tech companies, with the logos of AWS, Google Cloud, and Microsoft Azure appearing in the presentation.

This is not the first time Google and Amazon have been involved in providing civilian tech services to the Israeli military, nor is it the first time that questions have been raised about whether that technology is being used to facilitate human rights abuses. In 2021, Google and Amazon Web Services signed a $1.2 billion joint contract with the Israeli military called Project Nimbus to provide cloud services and machine learning tools located within Israel. In an official announcement for the partnership, the Israeli Finance Ministry said that the project sought to “provide the government, the defense establishment and others with an all-encompassing cloud solution.” Under the contract, Google and Amazon reportedly cannot prevent particular agencies of the Israeli government, including the military, from using its services.

Not much is known about the specifics of Nimbus. Google has publicly stated that the project is not aimed at military uses; the Israeli military publicly credits Nimbus with assisting the military in conducting the war. Reports note that the project involves Google establishing a secure instance of the Google Cloud in Israel. According to Google documents from 2022, Google’s Cloud services include object tracking, AI-enabled face recognition and detection, and automated image categorization. Google signed a new consulting deal with the Israeli Ministry of Defense based around the Nimbus platform in March 2024, so Google can’t claim it’s simply caught up in the changed circumstances since 2021.

Alongside Project Nimbus, an anonymous Israeli official reported that the Israeli military deploys face recognition dragnets across the Gaza Strip using two tools that have facial recognition/clustering capabilities: one from Corsight, which is a “facial intelligence company,” and the other built into the platform offered through Google Photos.
Clarity Needed

Based on the sketchy information available, there is clearly cause for concern and a need for the companies to clarify their roles.

For instance, Google Photos is a general-purpose service and some of the pieces of Project Nimbus are non-specific cloud computing platforms. EFF has long maintained that the misuse of general-purpose technologies alone should not be a basis for liability. But, as with Cisco’s development of a specific module of China’s Golden Shield aimed at identifying the Falun Gong (currently pending in litigation in the U.S. Court of Appeals for the Ninth Circuit), companies should not intentionally provide specific services that facilitate human rights abuses. They must also not willfully blind themselves to how their technologies are being used.

In short, if their technologies are being used to facilitate human rights abuses, whether in Gaza or elsewhere, these tech companies need to publicly demonstrate how they are adhering to their own Human Rights and AI Principles, which are based in international standards.

We (and the whole world) are waiting, Google and Amazon.



Paige Collings is the Senior Speech and Privacy Activist at EFF. As a lawyer, digital policy activist and community organiser, she works to dismantle systems of oppression and advance collective liberation. Paige focuses on highlighting how state surveillance and corporate restrictions stifle marginalized communities and perpetuate historic injustices and harm. She has worked with activists across the globe to facilitate systemic change by speaking truth to power and creating spaces for alternative imaginations for justice for all. Paige is a board member of the European Digital Rights (EDRi) network. Paige holds a Master’s degree in Law, Master’s degree in Political Science, and a Bachelor’s degree in Politics and History.

Saturday, August 17, 2024

 

Knocking out one key gene leads to autistic traits


RFK JR. WAS WRONG, AGAIN!

Rockefeller University
Purkinje cells 

image: 

Purkinje cells in the cerebellum, stained and magnified 63 times, revealing fine details of the dendritic spines.

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Credit: Laboratory of Developmental Neurobiology at The Rockefeller University




More than 70 genes have been linked to autism spectrum disorder (ASD), a developmental condition in which differences in the brain lead to a host of altered behaviors, including issues with language, social communication, hyperactivity, and repetitive movements. Scientists are attempting to tease out those specific associations gene by gene, neuron by neuron.

One such gene is Astrotactin 2 (ASTN2). In 2018, researchers from the Laboratory of Developmental Neurobiology at Rockefeller University discovered how defects in the protein produced by the gene disrupted circuitry in the cerebellum in children with neurodevelopmental conditions.

Now the same lab has found that knocking out the gene entirely leads to several hallmark behaviors of autism. As they describe in a new paper in PNAS, mice that lacked ASTN2 showed distinctly different behaviors from their wild-type nestmates in four key ways: they vocalized and socialized less but were more hyperactive and repetitive in their behavior.

“All of these traits have parallels in people with ASD,” says Michalina Hanzel, first author of the paper. “Alongside these behaviors, we also found structural and physiological changes in the cerebellum.”

“It’s a big finding in the field of neuroscience,” says lab lead Mary E. Hatten, whose work has focused on this brain region for decades. “It also underscores this emerging story that the cerebellum has cognitive functions that are quite independent of its motor functions.”

An unexpected role

In 2010, Hatten’s lab discovered that proteins produced by the ASTN2 gene help guide neurons as they migrate during the development of cerebellum and form its structure. In the 2018 study, they examined a family in which three children had both neurodevelopmental disorders and ASTN2 mutations. They found that in a developed brain, the proteins have a similar guiding role: they keep the chemical conversation between neurons going by ushering receptors off the neural surfaces to make room for new receptors to rotate in. In a mutated gene, the proteins fail to act and the receptors pile up, resulting in a traffic jam that hinders neuronal connections and communication. This impact could be seen in the children’s afflictions, which included intellectual disability, language delays, ADHD, and autism.

The find was part of a growing body of evidence that the cerebellum—the oldest cortical structure in the brain—is important not just for motor control but also for language, cognition, and social behavior.

For the current study, Hanzel wanted to see what effects a total absence of the ASTN2 gene might have on cerebellar structure and on behavior. Collaborating with study co-authors Zachi Horn, a former postdoc in the Hatten lab, and with assistance from Shiaoching Gong, of Weill Cornell Medicine, Hanzel spent two years creating a knockout mouse that lacked ASTN2, and then studied the brains and activity of both infant and adult mice.

Behavioral parallels

The knockout mice participated in several noninvasive behavioral experiments to see how they compared to their wild-type nestmates. The knockout mice showed distinctly different characteristics in all of them.

In one study, the researchers briefly isolated baby mice, then measured how frequently they called out for their mothers using ultrasonic vocalizations. These sounds are a key part of a mouse’s social behavior and communication, and they’re one of the best proxies researchers have for assessing parallels to human language skills.

The wild-type pups were quick to call for their mothers using complex, pitch-shifting sounds, while the knockout pups gave fewer, shorter calls within a limited pitch range.

Similar communication issues are common in people with ASD, Hanzel says. “It’s one of the most telling characteristics, but it exists along a spectrum,” she says. “Some autistic people don’t understand metaphor, while others echo language they’ve overheard, and still others do not speak at all.”

In another experiment, the researchers tested how ASTN2 mice interacted with both familiar and unfamiliar mice. They preferred to interact with a mouse they knew rather than one they didn’t. In contrast, wild-type mice always choose the social novelty of a new face.

This, too, has parallels in human ASD behavior, with a reluctance towards unfamiliar environments and people being common, Hanzel adds. “That’s a very important result, because it shows that mice with the knockout mutation do not like social novelty and prefer to spend time with mice they know, which corresponds to people with ASD, who tend to like new social interactions less than familiar ones.”

In a third experiment, both types of mice were given free rein to explore an open space for an hour. The ASTN2 mice traveled a significantly longer distance than the other mice, and engaged in repetitive behaviors, such as circling in place, 40% more. Both hyperactivity and repetitive behaviors are well-known hallmarks of ASD.

Miscommunication between brain regions

When they analyzed the brains of the ASTN2 mice, they found a few small but apparently potent structural and physiological changes in the cerebellum. One was that large neurons called Purkinje cells had a higher density of dendritic spines, structures that are spotted with the synapses that send neural signals. But they only detected this change in distinct areas of the cerebellum. “For example, we found the biggest difference in the posterior vermis region, where repetitive and inflexible behaviors are controlled,” Hanzel says.

The scientists also found a decrease in the number of immature dendritic spines known as filopodia and the volume of Bergmann glial fibers, which help with cell migration.

“The differences are quite subtle, but they are clearly affecting how the mice are behaving,” Hatten says. “The changes are probably altering the communication between the cerebellum and the rest of the brain.”

In the future, the researchers plan to study human cerebellar cells, which they’ve been developing for a half-dozen years from stem cells, as well as cells with ASTN2 mutations that were donated by the family in the 2018 study.

“We’d like to see if we can find parallel differences to what we found in mice in human cells,” Hatten says.

She continues, “We also want to look at the detailed biology of other genes that are associated with autism. There are dozens of them, but there’s no agreed-upon commonality that binds them together. We’re very excited that we’ve been able to show in detail what ASTN2 does, but there are a lot more genes to investigate.”

Friday, August 09, 2024

 

A ‘thank you’ goes a long way in family relationships




University of Illinois College of Agricultural, Consumer and Environmental Sciences




URBANA, Ill. – You’ve probably heard that cultivating gratitude can boost your happiness. But in marriage and families, it’s not just about being more grateful for your loved ones — it’s also important to feel appreciated by them. Researchers at the University of Illinois Urbana-Champaign have previously explored the positive impact of perceived gratitude from romantic partners for couples’ relationship quality. In a new study, they show the benefits of perceived gratitude also apply to parent-child relationships and can promote individuals’ mental health.

“Some of my previous research has looked at gratitude in an interpersonal context, particularly between couples, and we’ve found that it’s a pretty influential factor for various aspects of the relationship. Individuals who feel more appreciated by their partners are more confident, satisfied, and committed and less concerned about instability,” said lead author Allen BartonIllinois Extension specialist and assistant professor in the Department of Human Development and Family Studies, part of the College of Agricultural, Consumer and Environmental Sciences at Illinois. 

“In this study we wanted to explore perceived gratitude in the broader family context, and whether it makes a difference for individual and relationship well-being, and for parenting outcomes.”

The study included data from a nationwide sample of 593 parents who were married or in a romantic relationship and had at least one child between the ages of 4 and 17. Participants answered questions about perceived gratitude from their spouse or partner and from their children, as well as items assessing psychological distress, parenting stress, and relationship satisfaction.

The researchers divided children into two age ranges — 4 to 12 and 13 to 18 — to account for developmental differences. Barton says teenagers might be expected to have more awareness of what's going on in the family and what parents are contributing to their well-being. He notes that young children can still show gratitude, although they may express it differently.

Barton and co-author Qiujie Gong, a doctoral student in HDFS when the research was conducted, found that perceived gratitude from romantic partners resulted in better couple outcomes, but did not affect levels of parenting stress. In contrast, perceived gratitude from children — both older and younger — resulted in lower parenting stress but had no impact on couple relationship satisfaction. In addition to influencing family outcomes, they found that gratitude from romantic partners and older (but not younger) children was positively associated with individuals’ psychological well-being.

Women, compared to men, reported lower levels of perceived gratitude from romantic partners and from older children. Furthermore, higher levels of perceived gratitude from children provided beneficial effects for women only. That’s consistent with prior research showing that women's contributions to the family are often less acknowledged by men than vice versa, Barton said.

“It's never 50/50 in any relationship and parents are going to be doing more than their kids, but nevertheless, our results highlight that making sure individuals’ efforts for the family are acknowledged and appreciated by other family members is important. And conversely, there is clear evidence that a lack of feeling appreciated by the family members you're trying to help leads to negative outcomes for the family,” he noted. 

Barton said parents can foster an overall climate of gratitude in the family.

“As spouses and partners, we can express and show our gratitude for the other person, and we can teach children to express appreciation in developmentally appropriate ways. If you see your partner doing something really helpful for a child, you can remind that child to say ‘thank you, mom’ or ‘thanks, dad’ for what they just did. You can develop an ongoing way of thinking and a pattern of interaction that promotes gratitude — both giving and receiving — within the home,” he said.

The researchers did not find any differences in terms of socio-demographic factors predicting perceived gratitude in various family relationships, indicating it appears at similar levels across a wide range of family types.

“As someone who studies family-based prevention programming, I am always trying to find research-based ways to build strong families, and expressing gratitude appears as one important means of doing that,” Barton stated.

“There's a lot of work that goes into making ‘family’ happen — parenting, marriage, couple relationships, and so on — for any and every family. And when those efforts go unacknowledged or underappreciated, it takes a toll on individuals and families. We know the power of thank you for couples, and this research shows it also matters for parent-child relationships.”

The paper, “A ‘Thank You’ really would be nice: Perceived gratitude in family relationships,” is published in The Journal of Positive Psychology [DOI: 10.1080/17439760.2024.2365472].

Tuesday, July 16, 2024

This 2024 Election and the Metastatic Entrails of America


 
 JULY 16, 2024
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Image by Timon Studler.

It is as if we all synchronized our nightmares—or, rather, in a world of neoliberal austerity, we have run out of night-time horror tales and need to all share the same moth-eaten, unraveling, tedious bad dream. We have a tsunami of infected shit pouring mightily through our paper mache sea wall—a fierce, eternal heat wave, wars and genocides, fires, storms, poisons, plastics, and perverts oh my, and to make matters worse, our so called Democratic party has just discovered that the refrigerator went down in a blackout and the carton of milk turned as dank, sour, and foul as raw sewage. I am talking about Joe “I-supply-weapons-for-genocide” Biden, who just yesterday was as vibrant and clever as, uh… a normal person… and now, in a snap of the fingers, stares blankly into eternity like the two knotholes in your attic wall.

This sour milk emergency has provoked the Democratic Party big wigs—the people who could not possibly have known that Joe Biden’s wits had taken the uptown A-Train to oblivion without so much as leaving a note—to run in every direction at once in a frantic search for a warm, corporate friendly body to stuff into the empty ballot. I swear that if Curly of Three Stooges fame had gotten Ilse Koch pregnant, she might have given birth to the Democratic Party. The admixture of evil and slapstick ineptitude defies imagination. How do you not fucking know that your standard bearer, your champion of freedom and apple pie, has been stumbling into walls and wandering naked in the woods at night?

It appears as though the Democrats will finally put the gong show hook around grandpa’s waist, and call Kamala, or Pete Buttigieg, or Ronald MacDonald out of the storage bin to save our democracy. Fortunately, we live in the greatest country ever created and have so much freedom that we can’t figure out what to do with it all. We are free to vote for the Democratic clown car ticket, or the alternative, Night-of-the-Living-Dead party that just nominated Darth Vader and Heinrich Himmler as their candidates. Forgive me for my metaphoric extravagance—not the Vader/Himmler ticket, but Donald Trump and whatever evil fuckwit he bites in the throat to be his VP.And the beautiful thing about a Donald Trump/Joseph Goebbels ticket is that your vote automatically brings forth Clarence Thomas, Sam Alito, Stephen Miller, and Ted Bundy… oops, I mean Ted Cruz.

That is the lovely thing about democratic freedom and your choice to be yourself and vote for whomever the fuck you want, so long as it is a Democrat or Republican. We get to vote Clown Car or Nazi wannabe in a free and fair election. You get to “drill baby drill” or bomb Gaza into the sea of Armageddon.

We have free will and free choice: you get to live happily ever after in the stupor of our surrealistic dystopia, or you can (if you wish) bang your head against the padded walls of the insane asylum that is America. If this was some other country, some other planet, some other dimension of being, we might be out in the streets shutting it all down, but there are Amazon orders to wait for and TikTok videos to watch. We live in our perfectly ordered reality where nothing can shake us up. If a giant lobster from Andromeda landed in Wyoming wielding inter-galactic death rays in either pincer—so what?

The U.S. has an honorable history of mass protest. We all recall that Abbie Hoffman nominated a pig for president in 1968 Chicago, and that the mighty U.S. army turned tail in Vietnam and left Henry Kissinger with a mouthful of blood and guts looking for new outlets for his cannibalism. We have stopped wars and kicked scoundrels out of office. But those were simpler times. A mere four years ago we had millions in the streets over the police murder of George Floyd. How did that fizzle out and leave us all washed up—a nation of beached whales? The big question is this: how passively can we watch the planet burn to a crisp and remain as fatalistic about our political perpetrators as we all appear to be?

Phil Wilson is a retired mental health worker who has written for Common Dreams, CounterPunch, Resilience, Current Affairs, The Future Fire and The Hampshire Gazette. Phil’s writings are posted regularly at Nobody’s Voice.