Showing posts sorted by date for query psychedelic. Sort by relevance Show all posts
Showing posts sorted by date for query psychedelic. Sort by relevance Show all posts

Sunday, September 08, 2024

UK
Why Grenfell survivor Edward Daffarn was right to sound the alarm

The council painted Daffarn as a left wing ‘troublemaker’


A protest outside Kensington and Chelsea council, who attacked Daffarn, the day of the inquiry 
(Photo: Guy Smallman)

By Arthur Townend
Sunday 08 September 2024
SOCIALIST WORKERS Issue

Edward Daffarn is a survivor of the fire and a vocal resident of Grenfell. The Inquiry’s portrayal of Daffarn doesn’t just reveal the vile attitude of the Tenancy Management Organisation (TMO), but also the Inquiry’s underlying ideology.

The Inquiry says that the TMO’s repression of residents speaking out “reflects a serious failure on its part to observe its basic responsibilities”. But the report treats Daffarn as a troublemaker who blocked constructive relations between the TMO and Grenfell residents.

It continues, “The TMO regarded some of the residents as militant troublemakers led on by a handful of vocal activists, principally Edward Daffarn, whose style they found offensive. The result was a toxic atmosphere fuelled by mistrust on both sides.”

“The Inquiry is reflecting this feeling of nervousness that the ruling class feels when they are challenged by working class people,” housing campaigner Paul Burnham argued. “The language that is used is the same language used against shop stewards.

“They stereotyped Daffarn as a left wing ‘troublemaker’ who breaks up and disrupts productive meetings.

“In reality he was speaking out against the developers, so they had to silence him. All this smeary language that ends up in the report—it vindicates landlords who behave exactly the same as the TMO.”

The report doesn’t “treat people like people”. “They don’t talk about anyone else—it’s just Daffarn.”

Paul said the danger of a report that attacks victims in this way is that it sets a precedent going forward. He detailed how the report made this tension personal, but in reality it was a symptom of tensions between the ruling and working class.

“It’s not about hatred—it’s about the class, it’s about the material interests of the ruling class and not allowing any obstacles for this pursuit of profit,” said Paul.

“He was an antagonism to ruling class interests, so they had to attack him. People organising is a terrible threat to the establishment, so this brings it back to class struggle—it’s not a personal issue.”

The report does not directly blame the victims of Grenfell. It says that the “responsibility for the maintenance of the relationship between the TMO and the Grenfell community fell not on the members of that community”.

Nevertheless, it singles out Daffarn, saying, “Mr Daffarn perhaps should have stood back and questioned whether his preferred methods were the only, or even the most effective, way in which the voice of the community could be heard.”

“The report claims that whether he ever spoke for the wider community is debatable and his approach to the TMO caused resentment,” Paul said.

“That’s unacceptable because Ed’s work was supported by 100 people from 55 flats. The council’s response to this was to stop holding engagement meetings entirely—a traditional management strategy.”

The report implies that, if Daffarn had acted through the “proper channels”, the TMO would have had less hostility towards him. Perhaps it might have been more inclined to listen.

It’s an excuse for the ruling class to hide behind, diverting any questions away from the class divisions and anger that existed. The attack on Daffarn arises because the report has to defend the system of profit to avoid challenging the wider capitalist system.

Grenfell: corruption, greed and social murder

The Grenfell Inquiry’s report points the finger at the government, the council and construction bosses. But housing campaigners told Arthur Townend it doesn’t go far enough


Grenfell Tower (Picture: Guy Smallman)

By Arthur Townend
Sunday 08 September 2024
SOCIALIST WORKERS Issue


The fire in the Grenfell Tower in 2017 that killed 72 residents was a social murder more than 30 years in the making. It came out of a system that puts profit above people.

The building bosses, councils and Tory government have blood on their hands. The Grenfell Tower Inquiry released its final report last Wednesday, which covered some of this.

It attacks the individual actors that killed the Grenfell residents and touches on the role of the government and deregulation in causing the deaths. But the report does not address the systemic issues and fails to get to the root causes of the Grenfell fire.

It leaves intact the structures and incentives responsible for the murder. Moyra Samuels, a housing activist in north Kensington, said, “There’s a whole issue about how council housing has been robbed by governments.


“They took funding for refurbishments out of budgets, which is why council blocks end up in states of disrepair and become dangerous. Following Grenfell, we were clear that at the heart of the fire was the question of privatisation, outsourcing and cost-cutting.

“In terms of systemic failures, all the outsourcing and privatisation was so symbolic of neoliberalism.” Deregulation is crucial to understanding Grenfell and the housing crisis in Britain.

Paul Burnham from Haringey Defend Council Housing highlighted two critical aspects of deregulation behind the murder at Grenfell. “The first is the deregulation of building control, which used to be the local authority’s responsibility.”

Building developers now pay the regulatory body to have their buildings regulated. “It has now become something that developers buy into so it means that a building never fails the inspection.

“Related to that is materials testing, which is a classic example of deregulation’s failure. The body used to be public, but it was privatised. Now, there is a private arrangement between the developer and the tester of the materials.”

This means that the results of the tests are not public. Paul said that this was a very weak point of the report, as it recommends that results should be available on request.

But this is insufficient because the report doesn’t “draw the obvious conclusion that it needs to be automatically in the public domain and there needs to be a testing authority that is not beholden to the contract with the private developers”. And the report found conclusively—the companies that produced the cladding and insulation that burst into flames on Grenfell lied.

Celotex, which produced some of the insulation, cheated the fire safety test to make its product more marketable. The other insulation manufacturer Kingspan knew for over a decade its insulation was combustible.

Arconic, which made the cladding on Grenfell, deliberately concealed the safety certification of its cladding panels to keep selling them. “If testing is done by a company trying to get money out of the product, this is the logical action,” Paul said.

But the report doesn’t properly expose this logic—of how the push for profit drove companies to make decisions that killed residents of Grenfell. “It’s an establishment report with neoliberal assumptions, so it is not prepared to draw the conclusions that would challenge the system behind these decisions,” Paul said.

One question entirely absent from the Inquiry is that of race. “On top of developers ripping through communities and building for profit, we also have the question of Islamophobia,” Moyra said.

Because it was mostly Muslims living in social housing, activists argue that the council took their concerns less seriously. If rich white people were living there, it’s likely that the council would have acted sooner.

Instead, the council of the richest borough in Britain took a dismissive attitude towards working class people and ethnic minorities, which proved deadly. “It’s institutional discrimination from the council. People want to make the case the council was in breach of the 2010 Equalities Act.”

Leaving out the question of race and Islamophobia was not an accident, but a deliberate decision. “They wouldn’t allow racism and discrimination” in the Inquiry.

“Justice4Grenfell also asked for social housing to be included in our terms of reference in the Inquiry but they wouldn’t allow it,” Moyra said. “The fact that we are not allowed to bring social housing or the issue of race into the inquiry shows the systemic failures.

“They cannot talk about these issues because it points to the wider system”—not just regulation or bad actors in specific companies. The Inquiry calls for “fundamental change” in the construction industry.

It says a regulator should oversee all aspects of the construction industry and that a government department should take responsibility for fire safety. And it demands a mandatory strategy for fire safety in high-risk buildings.

But the recommendations don’t even begin to undo the decades of deregulation and privatisation—let alone the class and racist prejudices—which led to the murder at Grenfell.
Crime and no punishment for politicians and bosses

Council and corporate bosses involved in the fire are criminals—and should be treated as such. Here are some of the top criminals.

Elizabeth Campbell took over as Tory leader of Chelsea and Kensington council in the aftermath of the disaster. At the time of the Grenfell fire, Campbell refused to apologise for the council’s actions before the fire—the council had tried to sue residents for raising safety concerns.

She remains the leader of the council. Her predecessor, Nicholas Paget-Brown was forced to stand down in the aftermath of the fire.

The disgraced Tory landed on his feet. He set up NPB Consulting, a firm to advise companies that want to do business with councils.

Rock Feilding-Mellen was the former deputy leader of Kensington Council and responsible for housing. After Grenfell, he co-founded Beckley Waves, a psychedelic therapy company.

He said taking magic mushrooms during a therapy session in Jamaica “quite literally turned my life around”. He previously said, “My heart will always ache because of their pain and suffering”—that he helped cause and has disgustingly used for financial gain.

Arconic deliberately concealed the safety risks of its cladding. Tim Myers, chief executive from 2020-23, cashed in shares of £22.3 million on top of £23.9 million in pay since Grenfell.

Chief executives Erick Asmussen and Mark Vrablec made a further £9.2 million from share sales plus £9.2 million in pay, bringing the trio’s total to almost £65 million.

Kingspan knew since 2005 that its insulation was dangerous and combustible. Eugene Murtagh, Kingspan’s founder, banked £149.3million from share sales in the seven years since Grenfell.

His son Gene Murtagh, Kingspan’s chief executive, sold a £3 million block of shares just before the damning fire test evidence emerged at the Grenfell Inquiry.

Celotex cheated fire safety exams to make its insulation more marketable. Since the fire, chief executive Pierre-AndrĂ© de Chalendar has taken £11.7 million, while his successor Benoit Bazin has pocketed £15.8 million since 2021.

Rydon refurbished Grenfell in 2015. Of the blocks it has built like Grenfell, 56 percent have “life critical” fire safety issues.

Michael Gove claims Treasury blocked his efforts to punish Grenfell cladding firms


‘The task now falls to others to secure the justice I sought but failed to bring,’ Michael Gove says

Andy Gregory
THE INDEPENDENT
Sept. 8, 2024

Tory former housing secretary Michael Gove has claimed that the Treasury impeded his efforts to punish firms responsible for the flammable cladding on Grenfell Tower.

The damning final report of the seven-year inquiry into the blaze which killed 72 people on 14 June 2017 this week accused the three firmsArconic, Celotex and Kingspan – whose cladding products were installed at Grenfell of “systematic dishonesty”.


The firms “engaged in deliberate and sustained strategies to manipulate the [fire safety] testing processes, misrepresent test data and mislead the market”, the 1,600-page report by Sir Martin Moore-Bick found.

In the wake of the report’s publication, the bereaved relatives of those who died in what was the worst residential fire since the Second World War are demanding manslaughter charges for those responsible after seven years without justice.

With pressure growing on government figures over the lack of accountability for Grenfell, Mr Gove – who served as housing secretary for more than two years prior to the July election – claimed in an article forThe Sunday Times that his own efforts to punish the cladding firms were stymied.

“The task now falls to others to secure the justice I sought but failed to bring,” Mr Gove wrote. “I hope the Crown Prosecution Service and Metropolitan Police will do all they can to bring criminal prosecutions quickly.


“But pursuing a few of the most guilty individuals is not enough when these companies are still making vast profits without acknowledging their full responsibility.”

Accusing the three firms of having “willingly, knowingly, recklessly put greed ahead of decency”, Mr Gove alleged that his own attempts to restrict imports of their products ran up against the “commercial purism of Treasury Mandarin Brain”. The Treasury was approached for comment.

Former housing secretary Michael Gove apologised to the relatives and survivors of the Grenfell Tower fire (Aaron Chown/PA)

And the former Tory minister said there had been “insufficient action” from foreign governments on companies based overses.

“Because Kingspan is based in Ireland, and Arconic’s European operations and Celotex are in France, our jurisdiction was limited. But we were determined to go after them,” Mr Gove said.

He claimed to have “pressed the Irish government to act against Kingspan without success”, while receiving “only haughty froideur” from France.


Warning that “taking the necessary action will require toughness”, he wrote: “I worry that the new government may be dissuaded from doing everything necessary by those counselling caution.”

Grenfell United had called for Arconic witnesses in France to come to give evidence to the Grenfell Tower Inquiry (Kirsty O’Connor/PA)

Citing arguments in Whitehall that the cladding firms “can be partners in combating climate change”, that the UK “shouldn’t pick fights with EU neighbours when we want a closer commercial relationship” and that pursuing companies abroad could deter foreign investment, Mr Gove said: “I understand all those arguments.

“But you cannot purchase prosperity at the price of justice. You cannot build a safe home for the vulnerable on an unquiet grave. You cannot allow the unacceptable face of capitalism to be left smirking when the tears of victims are still wet. Those who are the guiltiest must pay, and pay the most.”

However, Grenfell Next of Kin – a group whose immediate family members died at Grenfell – accused Mr Gove of “historical revisionism”.

In a statement to The Independent, the group said: “Has he forgotten he was in cabinet almost continuously from 2010 onwards, and the coalition government of David Cameron with his policy of ‘bonfire of regulations’ which launched a deregulation of planning standards? The political and policy decisions that embraced the ‘unacceptable face of capitalism’ he speaks of?

“He nudges us with emotive language of ‘purchasing prosperity at the price of justice’ and ‘our wet tears’ when it was precisely these policies that created the wild west conditions that allow these manufacturers to do harm.

“It is the ashes of his government’s ‘bonfire of regulation’ that were returned to us, the ashes of our kin to be buried. Thanks for championing our justice, but we think we got this from here on.”

Members of a support group for the next of kin and families of some the 72 people killed in the Grenfell Tower fire (Yi Mok/PA)

Warning that all those to blame for Grenfell need to be punished, the group added: “The deliberate deflection of the responsibility of the state in our tragedy by Michael Gove ignoring the role of the Royal Borough of Kensington and Chelsea, a Tory jewel in the crown where he and half the Tory cabinet lived at the time of the fire, and the Tory government at the time of the refurbishment of the tower, is historical revisionism at best.”

Apologising in The Times for the government’s failures, Mr Gove criticised the “many others who failed the victims of Grenfell”, including tenant managers, Kensington and Chelsea Borough Council, the Building Research Establishment, and developers


Speaking to the BBC’s Sunday With Laura Kuenssberg, Sir Keir Starmer said “appropriate cases should go through to court”, with the prime minister adding: “The worst we could do is say or do anything which would prejudice the outcome of any proceedings.”

Additional reporting by PA

Wednesday, September 04, 2024


Psychedelics show promise for treating PTSD by suppressing learned fear responses



New research reveals how psychedelic drugs like psilocybin acutely reduce fear by altering activity in the amygdala, a key brain region involved in processing fear and anxiety




Genomic Press




MILWAUKEE, WI - Ongoing research is revealing how psychedelic drugs like psilocybin (the active ingredient in "magic mushrooms") and LSD may help treat post-traumatic stress disorder (PTSD) by suppressing learned fear responses. In a new Bench to Bedside peer-reviewed article published in the journal Psychedelics (ISSN: 2997-2671, Genomic Press, New York), researchers from the Medical College of Wisconsin provide an in-depth look at the neural mechanisms underlying psychedelics' acute fear-reducing effects in rodent models of PTSD.

The amygdala, an almond-shaped structure deep within the brain, plays a central role in fear learning and expression. Excitatory neurons in the lateral amygdala are activated by fearful stimuli, leading to a cascade of activity that drives fear responses. The new research proposes that psychedelic drugs suppress this fear-related activity by enhancing inhibitory signaling from GABAergic interneurons onto the excitatory neurons.

"Our hypothesis is that psychedelics acutely suppress learned fear responses by activating serotonin 2A receptors on inhibitory neurons in the amygdala," said the lead author Thomas Kelly, an MD/PhD candidate. "This leads to increased release of the inhibitory neurotransmitter GABA, which quiets the activity of excitatory neurons that normally drive fearful behaviors."

The finding that psychedelics' acute effects on fear require activation of serotonin 2A receptors aligns with the receptor's established role in the drugs' hallucinogenic effects. However, the authors emphasize the importance of considering the broader pharmacological profile and duration of action of different psychedelic compounds.

For example, the drug MDMA, which has shown promise for treating PTSD in late-stage clinical trials, does not directly activate serotonin 2A receptors. Instead, MDMA increases the release of serotonin, which then activates various serotonin receptor subtypes. The research suggests that psychedelics with faster onset and shorter duration of acute effects may be advantageous for PTSD treatment compared to longer-acting drugs like LSD.

"The insights from preclinical studies can help guide the design of clinical trials and treatment protocols that optimize the therapeutic potential of psychedelics for PTSD," said senior author Dr. Qing-song Liu. "By understanding the mechanisms and time-course of psychedelics' effects on fear circuitry, we can better harness these compounds in a clinical setting."

Several clinical trials are currently investigating psilocybin-assisted therapy for PTSD, with some protocols incorporating drug administration in combination with exposure therapy to promote fear extinction learning. As this research progresses, the amygdala is emerging as a key locus of interest for understanding how psychedelics may extinguish fearful memories and provide a novel treatment approach for PTSD and other fear-related disorders.

The full article, titled “Exploring the therapeutic potential of psychedelics: Fear extinction mechanisms and amygdala modulation,” was published online on 09 August 2024 and is freely available online at the website of Psychedelics (Genomic Press, New York): https://pp.genomicpress.com/aop/

Contact: Thomas J. Kelly Medical College of Wisconsin tjkelly@mcw.edu 1-920-427-6177

Wednesday, August 28, 2024

 

National Institutes of Health awards $2.4 million grant to cross-disciplinary team of researchers to study psychedelics for methamphetamine addiction



Research project led by Drs. John McCorvy, Adam Halberstadt, and Kevin Murnane selected by NIDA for first-ever funding opportunity to investigate the therapeutic potential of psychedelics to combat methamphetamine addiction.



Medical College of Wisconsin





 

Milwaukee, Wis., August 27, 2024 – John McCorvy, PhD, Assistant Professor in the Department of Cell Biology, Neurobiology, and Anatomy at the Medical College of Wisconsin (MCW); Adam Halberstadt, PhD, Professor of Psychiatry at the University of California San Diego (UCSD) and Director of the UCSD Center for Psychedelic Research; and Kevin Murnane, PhD, Associate Professor of Pharmacology, Toxicology, and Neuroscience and Director of Basic Science Research for the Louisiana Addiction Research Center at LSU Health Shreveport, were recently awarded a five-year, $2.4 million research grant from the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), to uncover critical insights into how psychedelics could be used as a therapeutic to treat methamphetamine addiction.

Stimulant use disorder and methamphetamine-related overdose deaths are escalating at an alarming rate. According to data from NIDA, the number of overdose deaths in the United States involving psychostimulants (primarily methamphetamine) has grown significantly since 2015 when there were 5,716 attributed deaths. In 2022, NIDA reported 34,022 overdose deaths involving psychostimulants – a nearly 500% increase from 2015 to 2022.

Psychedelic substances, like psilocybin, have shown promise in treating a wide range of behavioral health conditions, including anxiety, depression, alcoholism, and nicotine dependence. However, these substances interact with multiple receptors and are not specifically selective for the serotonin 5-HT2A receptor, which is vital for their psychoactive effects. The research spearheaded by Drs. McCorvy (MCW), Halberstadt (UCSD), and Murnane (LSU) seeks to understand the specific role of 5-HT2A receptor signaling in mitigating the effects of methamphetamine use.

“There are currently no pharmacological treatments for methamphetamine addiction. Our research aims to unravel the precise mechanisms through which psychedelics influence the 5-HT2A receptor – understanding that could lead to lessening their psychoactive effect and open the door to new treatments,” said Dr. McCorvy. “This project’s findings could ultimately pave the way for new therapeutic approaches to treat stimulant use disorder, impacting the lives of so many who are coping with addiction.”

The significance of this research extends beyond the immediate goal of finding new treatments for methamphetamine addiction. Understanding which serotonin receptors facilitate the beneficial effects of psychedelics can pave the way for developing targeted therapies that minimize psychedelic effects, potentially allowing for daily or regular use without impairing the patient’s daily life.

As Dr. Halberstadt noted, “Psychedelics appear to have significant therapeutic activity against different types of substance abuse and other psychiatric disorders. However, existing psychedelics induce intensive psychoactive effects and can also induce side-effects in some individuals, complicating the clinical use of these substances and restricting their widespread application. Our project seeks to understand the mechanism for the therapeutic effects of psychedelics against methamphetamine addition, potentially enabling development of a new generation of molecules with effects that are much more manageable and better tolerated.”

As Dr. Murnane noted, “For methamphetamine addiction, the current standard of care involves behavioral treatments with limited success rates over multiple cycles of therapy. This creates a public health imperative to research new and deliver effective therapies for methamphetamine addiction. This research project will advance psychedelics as a promising new treatment option based on reported data in initial clinical studies, as well as our own preliminary research. It will also unlock understanding into key physiological mechanisms that drive methamphetamine addiction, as well as therapeutic response mechanisms, allowing the development of second-generation serotonin agents with improved profiles.”

NIDA recently solicited grant applications for innovative research projects that employ psychedelics for drug addiction. This project – Investigations into 5-HT2A signaling mechanisms of psychedelic drugs for the treatment of stimulant use disorder – was one of only two non-clinical trial grant applications selected for funding by NIDA.

“We’re thrilled to receive this first-of-its-kind funding from NIDA to conduct such unique and innovative research. It not only validates our approach to studying psychedelics but highlights the urgent need for new treatments for methamphetamine addiction,” said Dr. McCorvy. “Our goal is to leverage cutting-edge chemical biology tools to unravel the specific mechanisms by which psychedelics exert their effects, potentially leading to novel therapies that can significantly impact public health.”

This research is timely and crucial given the alarming rates of methamphetamine overdoses, especially in the southern and western United States where methamphetamine was the most common drug in overdose deaths in 2017, surpassing those from opioid overdoses. The study’s findings could lead to novel, effective treatments for a problem that has long lacked viable medical solutions.

 

NOTE: Drs. McCorvy, Halberstadt, and Murnane are available for interviews. Please contact the press office for their respective institutions to schedule: MCW – media@mcw.edu; UCSD – k3hendrickson@ucsd.edu; LSUHS – lisa.babin@lsuhs.edu.

#             #             #

About the Medical College of Wisconsin

With a history dating back to 1893, the Medical College of Wisconsin is dedicated to leadership and excellence in education, patient care, research and community engagement. More than 1,600 students are enrolled in MCW’s medical, graduate and pharmacy schools at campuses in Milwaukee, Green Bay and Central Wisconsin. MCW’s School of Pharmacy opened in 2017. A major national research center, MCW ranks in the top 1% of U.S. research institutions (National Science Foundation), is the largest research institution in the Milwaukee metro area and is the largest private research institution in Wisconsin. Annually, our faculty direct or collaborate on more than 3,500 research studies, including clinical trials. In the last 10 years, MCW faculty have received nearly $2 billion in external support for research, teaching, training and related purposes. Additionally, our more than 1,700 physicians provide care in virtually every specialty of medicine, annually fulfilling more than 4 million patient visits.

 

About the University of California San Diego 

UC San Diego is recognized as one of the top 20 research universities in the world and received more than $460 million in NIH grants in 2023. UCSD includes six undergraduate residential colleges, two professional medical schools (UCSD School of Medicine and Skaggs School of Pharmacy and Pharmaceutical Sciences), the Scripps Institution of Oceanography, the Qualcomm Institute, the San Diego Supercomputer Center, and the Kavli Institute for Brain and Mind. It offers over 200 undergraduate and graduate degree programs, enrolling more than 20,000 undergraduate students and more than 6,000 graduate and professional students.

 

About Louisiana State University Health Shreveport

LSU Health Shreveport is one of two health sciences centers of the Louisiana State University (LSU) System and home to the only academic medical center in a 150-mile radius. The primary mission of LSU Health Shreveport is to teach, heal, and discover in order to advance the well-being of the state, region and beyond. LSU Health Shreveport encompasses the School of MedicineSchool of Graduate Studies and School of Allied Health ProfessionsGraduate Medical Education (GME), and a robust research enterprise. For more information, visit www.lsuhs.edu.

Sunday, August 25, 2024

UK

Bristol man was recalled to prison after visiting an anarchist social centre

From The Bristol Cable by Tom Anderson

Original title: Under surveillance: how a Bristol man was recalled to prison after visiting an anarchist social centre

Toby Shone’s arrest by counter-terrorism police surveilling the BASE centre in Easton shows the state’s escalating clampdown on political dissent.

Members of Easton-based anarchist social centre BASE recently discovered that they’re being monitored by counter-terrorist police, after a man was recalled to prison after attending one of its events.

Toby Shone was initially arrested on terrorism and drugs charges in November 2020, as part of a wider police operation named Op Adream. Police believed Toby was the editor of the 325nostate.net anarchist website, which they said contained material that encouraged terrorism.

The Crown Prosecution Service (CPS) also found psychedelic drugs during the raid on his home and charged Toby with terrorism and drugs offences. He denied all charges, and on the eve of Toby’s court case, the CPS indicated it was dropping the terrorism allegations against him. It offered no explanation for the sudden change of heart.

Toby was convicted of possession and intent to supply Class A and B drugs, and sentenced to three years and nine months in prison. Despite not being convicted of any terror offences, Toby’s supporters say he was – and is being – treated like a terrorist in prison. When he was released, in December 2022, it was under heavy restrictions and monitoring by the multi-agency National Security Division (NSD), which manages terror cases.

Last September he was recalled to prison after being arrested by armed police acting on the orders of Counter Terrorism Policing South West (CTPSW). The grounds for the 46-year-old’s arrest were that he hadn’t complied with his probation licence conditions when he was released part way through his prison sentence.

Police say he breached his conditions by attending a letter-writing event at BASE, and using a phone that wasn’t registered with his probation officer. Toby said he did not submit details of the phone he was using as many of his comrades had already been spied on by undercover police and didn’t want them to be subject to further surveillance.

Legal papers served to Toby showed BASE was under ongoing surveillance and monitoring by CTPSW, and that police officers had compiled ‘evidence’ about events being held at the Easton social centre.

BASE members, in a collective statement, said they were shocked to hear of Toby’s recall to prison and to find out that they were being monitored:

“There is a suggestion that there is some shadowy criminal anarchist group behind BASE so that the cops can expand their fantasy of ‘anarchist terror’ where a social centre is somewhere that people become groomed and radicalised and where glorification and funding of terrorism are rampant,” it said.

“Back in the real world, BASE is a much-loved and long-standing autonomous social centre that hosts community dinners, bike workshops, [and] talks on a diverse range of topics from social justice and prisoner solidarity to environmental and cultural topics.”

BASE also ran a community mutual-aid project during the Covid pandemic.
Treated like a terrorist

Toby’s case is one of the only prosecutions of anarchists under modern terrorism legislation in the UK, and he’s been hounded by counter-terrorism police for over four years. How and why he was sent back to jail, at HMP Garth, 170 miles from his home, is a story campaigners say highlights the British state’s attempts to silence people with oppositional political views.

The 325 website and publication publishes reports of direct action, discusses anarchist political thought, and makes calls for solidarity with anarchist prisoners, and the anarchist movement more broadly.

In an interview with a US-based anarchist radio station, Toby explained that the case against him hinged on the idea that 325 encouraged terrorism, and made a tenuous link between content on 325 and a Greek armed Marxist-Leninist group called November 17th, which is proscribed as a terrorist group here in the UK. This enabled them to utilise terrorism legislation.

In an era of ever-increasing state surveillance and a renewed crackdown on our right to protest, Toby’s case shows how far the state is willing to go to silence dissent

Kat Hobbs, Netpol

Toby’s supporters say he has been persistently treated like a terrorist in prison. He spent the first year on remand, before his court case, in Category A prisons in Wandsworth and Belmarsh. He was denied visits by his lawyers for the first six weeks of his imprisonment, and he wasn’t shown the evidence against him for many months.

Prior to his release, police tried to impose a Serious Crime Prevention Order (SCPO) on him. If granted, the SCPO would have imposed tight restrictions on his freedom for five years after his release, and could be renewed indefinitely. It would have restricted who he could meet, as well as his use of tech security tools like encrypted messaging and virtual private networks (VPNs).

Toby’s lawyers, however, were able to successfully contest these restrictions at a court hearing in May 2022.

Prison authorities have, for a long time, been restricting Toby’s communication with the outside world. Letters and emails sent to and from prison are routinely censored.

He has been unable to receive several books and other publications through the post, despite the fact that the right for prisoners to be sent books has been hard fought for. In autumn 2022, anarchists held a noisy demonstration outside HMP Parc near Bridgend over the restrictions, and the prison moved Toby to a segregation cell as a result.

We spoke to Sarah*, a friend of Toby’s, about the effects this censoring of mail and isolation is having on Toby and those close to him.

She said prison authorities had even stopped a birthday card that Toby had sent to his elderly parents from getting out during his sentence. Sarah said the intention was to “demoralise him and disable Toby’s perception of support” from his family, friends, comrades and the anarchist movement in general. According to Sarah, “this is a stated goal in probation paperwork”.

“This is a politically motivated decision that extends beyond Toby and reveals the authoritarian nature of the state we are living in at this time. His recall for attending an anarchist social centre makes it clear that somewhere like BASE is considered a threat to ‘national security’,” Sarah added.

Sarah has been stopped at UK borders under Schedule 7 of the Terrorism Act as part of the ongoing Operation Adream and interrogated about her ideas, relationships and personal life. She said the restrictions and surveillance on Toby’s communications mean she “censors her language, ideas and feelings” to avoid being removed from his agreed contact list and having her written communications censored by the prison authorities. She told us that everything she says to Toby is “being analysed, which feels intrusive and uncomfortable”.
Silencing dissent

Kat Hobbs is part of the Network for Police monitoring (Netpol), an organisation monitoring the escalation of police powers in the UK. She told the Cable the use of terror charges against Toby for holding anarchist beliefs could be a harbinger of things to come.

“In an era of ever-increasing state surveillance and a renewed crackdown on our right to protest, [Toby’s case shows] how far the state is willing to go to silence dissent,” she said.

The use of repressive charges against anarchists is nothing new. In 1997 three editors of Green Anarchist and two people linked to the Animal Liberation Front were prosecuted and jailed for three years for the publication allegedly having incited others to commit criminal damage. They were later released and their convictions overturned. In Toby’s case, prosecutors dialled things up significantly by making allegations of terrorism.

And in 2017 Joshua Walker was charged with possessing terrorist information for downloading the Anarchist Cookbook, a manual with instructions for making weapons. He was later cleared.

“We have known for a long time that intrusive police surveillance targets left movements, and the ongoing ‘spy cops’ inquiry keeps exposing how far the police are willing to go,” said Kat. “BASE social centre will not be the only place under surveillance for sharing leaflets and serving vegan food. For someone to face prison time for joining a letter-writing session with friends is chilling. Netpol stands in solidarity with Toby Shone.”

BASE said Toby’s treatment shows that state repression of our movements will only increase, and that Toby is likely to not be the “last of us to be locked up for our politics. As long as places like BASE are used by people engaged in shared radical politics, they will continue to be sites of surveillance, repression and draconian policing. We stand with Toby not only for the sake of his freedom, but for the sake of all of ours as well!”

“Toby’s case shows us clearly that we in the UK do not have the right to freely organise with others”.

The Cable contacted the Ministry of Justice for comment on Toby’s case. A spokesperson said: “Offenders released on licence are kept under close supervision and will be recalled to prison if they break the rules”. They declined to comment on the disruption to Toby’s mail into and out of the prison. We also contacted CTPSW, but received no response.

This lack of a substantial comment from either authority is indicative of a lack of transparency over the actions of the police and prison service.

Visit the BASE site to learn more about the centre, or for further information on Tony’s case and prisoner solidarity check out Brighton ABC or Bristol ABC.

Wednesday, August 21, 2024

New study provides further support for psilocybin’s potential to treat depressive symptoms


High dose psilocybin was the only psychedelic treatment to reduce depressive symptoms by more than placebo in antidepressant trials



BMJ Group


High doses of psilocybin - the active ingredient in magic mushrooms - appears to have a similar effect on depressive symptoms as the selective serotonin reuptake inhibitor (SSRI) drug escitalopram, suggests a systematic review and meta-analysis published in The BMJ today.

The findings show that patients treated with high dose psilocybin showed better responses than those treated with placebo in antidepressant trials, although the effect size was small.

The researchers point out that flaws in study designs may have overestimated the effectiveness of psychedelics, but say high dose psilocybin “appeared to have the potential to treat depressive symptoms.”

Psychedelic treatment has shown promise in reducing depressive symptoms. However, only one randomised controlled trial has so far directly compared a psychedelic drug (psilocybin) with an antidepressant drug (escitalopram) for patients with major depressive disorder.

What’s more, the subjective effects of psychedelic substances can compromise blinding, leading to overestimation of treatment effects compared with placebo. Psychedelic treatment is also usually given with psychological support which makes isolating the direct effects of psychedelics difficult.

To try and address these issues, the researchers trawled scientific databases to identify randomised controlled trials published up to 12 October 2023 that assessed the effects of psychedelics or escitalopram in adults with acute depressive symptoms.

To be eligible, psychedelic treatment (including MDMA, LSD, psilocybin, or ayahuasca) had to be given orally with no additional use of antidepressants, while escitalopram trials had to compare at least two different oral doses (maximum 20 mg/day) with placebo. Trials comparing psychedelic therapy directly with escitalopram were also included. 

Overall, 811 people (average age 42; 54% women) were included in 15 psychedelic trials and 1,968 people (average age 39; 63% women) were included in five escitalopram trials.

Effect size was expressed as standardised mean difference (0.2-0.5 indicates a small effect, 0.5-0.8 a moderate effect, and 0.8 or more a large effect).

The researchers found that placebo responses in psychedelic trials were lower than in escitalopram trials. As a result, while most psychedelics performed better than placebo in psychedelic trials on the 17 item Hamilton depression rating scale (HAMD-17), only high dose psilocybin performed better than placebo in escitalopram trials on the HAMD-17 scale, showing a small effect size (standardised mean difference 0.3), which is similar to that of current antidepressant drugs.

None of the interventions was associated with a higher rate of severe adverse events (including death, admission to hospital, or suicide attempt) or discontinuation than placebo.

The authors acknowledge several study limitations, including that only acute effects of the interventions were assessed and that the long term effects of psychedelics and escitalopram remain unclear. The sample size of the psychedelic trials was small, they add, and the effects of high dose psilocybin may have been slightly overestimated compared with other treatments.

Nevertheless, they conclude: “Serotonergic psychedelics, especially high dose psilocybin, appeared to have the potential to treat depressive symptoms. Our analysis suggested that the standardised mean difference of high dose psilocybin was similar to that of current antidepressant drugs, showing a small effect size.”

They add: “Improved blinding methods and standardised psychotherapies can help researchers to better estimate the efficacy of psychedelics for depressive symptoms and other psychiatric conditions.”

[Ends]

Monday, August 19, 2024

What is microdosing? An introduction to the psychedelic wellness trend and why it’s so popular

Microdosing with drugs like psilocybin has become so popular that advocates want to bring it above ground


A jar of freeze-dried Jack Frost mushrooms at the combined booth of Fruity Spores and Sacred Three Mushrooms during the inaugural Shroom Fest Sunday, June 9, 2024 at ReelWorks Denver. (Photo by Daniel Brenner/Special to The Denver Post)


By Tiney Ricciardi | cricciardi@denverpost.com | The Denver Post
UPDATED: August 19, 2024 

In late 2023, Crystal Peterson was feeling desperate.

The 44-year-old Cortez resident had long suffered from panic attacks that awoke her in the middle of the night. As the nights grew longer with the onset of winter, her mental anguish worsened.

Peterson had tried taking medication to help her sleep. She also experimented with mindfulness techniques like meditation and yoga. She even tried equine therapy, exercising more and changing her diet – nothing alleviated the feelings of overwhelm and distress.

Last December, Peterson decided to try microdosing psychedelic mushrooms after attending an informational session about the practice. She began working with a coach to determine a regimen that suited her needs, and within days, Peterson said she noticed improvement.

“The mushrooms helped me compartmentalize my stresses,” she said. “The things that are usually overwhelming and, ‘Oh my god!’ in my head are like, ‘No, you got this. We’re going to do this one step at a time.’ … I’ve really, really liked having less stress.”

As research into psychedelics has expanded, many Americans have turned to microdosing as a holistic alternative to improve their mental health. The practice involves taking a small dose of psychedelics as a supplement to enhance mood and cognitive function. While there’s limited scientific data to support how well – or if – microdosing works, anecdotal reports like Peterson’s number in the tens of thousands of people who say it’s helped them manage a wide variety of conditions, from chronic pain to creativity.

Psilocybin, one of the most commonly used drugs for microdosing, is now decriminalized in Colorado, though it remains a federally scheduled substance. Fueled by their personal experiences, advocates aim to bring microdosing above ground and make it more accessible. That includes one biotechnology company in Colorado that’s developing a full-spectrum psilocybin formula it hopes to put through clinical trials and get approved by the U.S. Food and Drug Administration. (The company, AJNA BioSciences, has a license from the Drug Enforcement Administration to conduct research.)

“When it’s used correctly with the right education and support, it can have a massive impact in people’s lives,” said Alli Schaper, co-founder of the advocacy organization Microdosing Collective. “We estimate there’s thousands of illicit market brands shipping microdosing supplements across the U.S. We might as well legalize it and make it safer.”
Displays illustrating psychedelic mushrooms are seen at the MAPS conference at the Colorado Convention Center in Denver on June 21, 2023. MAPS stands for Multidisciplinary Association For Psychedelic Studies.
 (Photo by Helen H. Richardson/The Denver Post)


Guidelines for getting started

Because microdosing isn’t standardized like traditional medicine, there are few hard and fast rules about how to do it. Over time, however, the underground community has developed general guidelines.

For example, a microdose is supposed to be “sub-perceptual,” meaning an amount small enough that the drug does not cause a trip or significant impairment. Most say the sweet spot is between .1 and .4 grams of dried psilocybin mushrooms. But exactly how much requires personal experimentation since no two mushrooms are identical and each individual’s sensitivity to the substance is unique.

People often grind up dried mushrooms and put them in capsules for consumption, and sometimes they add non-psychoactive fungi like lion’s mane or reishi. There is an abundance of illegal microdosing products available to buy online, but because they are unregulated it’s impossible to know if the dosages and ingredients are as advertised without lab testing.

A widely cited rule of thumb: Start low and go slow.

Jayme Ely, a microdosing mentor based near Telluride, advises trying your first dose on a day with few or no obligations. Start at the low end of the spectrum – somewhere around .1 or .2 grams of mushrooms – to get a baseline understanding of the effects.

“Do it on Sunday when you’re just at home, see if you feel anything,” Ely suggested. “With microdosing you don’t feel anything. The effects are so subtle you don’t even notice it.”

If you want to up the dosage, do so incrementally, Ely said, or you could become nauseous or experience a mild trip, which are both common effects of ingesting psilocybin. The goal is to find a threshold, but not cross it to the point of hallucinating or impairment.

“If you take a microdose and you find you’re going through your day and everything is wonderful, fine. Drive yourself to work the next day, or lunch or whatever. If you go beyond the recommendations, you might have some experiences… like not feeling in control or not feeling comfortable, feeling nauseous or out of my zone a little bit,” she said.

After determining a dosage, it’s time to decide how often to microdose. Regimens vary widely, though once again there are some templates.

Famed mycologist Paul Stamets has advocated for microdosing four days in a row and then abstaining for the rest of the week. The Fadiman Protocol, named for researcher James Fadiman, calls for microdosing once every three days. Still, some people do it every other day or even just as needed.

For those just starting out, Ely recommends following Stamets’ schedule – four days on, three days off – to set a baseline.

“I always tell people, stick with the four days, even if you think you’re healed and the world has changed the next day. Stay consistent for four days at least,” she said.
Surge in popularity

Even though psilocybin was decriminalized in Colorado in 2022, there are no prescription formulas approved by the FDA that doctors can prescribe to patients who want to try microdosing. Complicating matters further is the fact psilocybin remains a federally scheduled substance alongside LSD or acid, another popular microdosing drug.

Without guidance from healthcare professionals, people have turned to online communities to fill in the information gaps. According to a recent study, internet searches for microdosing have skyrocketed by 1,240% since 2015. About 275,000 people share and seek advice about it in the /microdosing subreddit.


Tracey Tee, founder of Moms on Mushrooms, in the woods near her home in Franktown, Colorado on July 16, 2024. Moms on Mushrooms is a virtual community where women can go to learn about microdosing with psychedelics and connect over their experiences as parents. (Photo by Helen H. Richardson/The Denver Post)

Coloradan Tracey Tee recognized the need for a safe space where women could learn about microdosing and connect over their shared experiences as parents. In 2022, she founded a virtual group called Moms on Mushrooms, which has grown to about 3,000 members. Tee said the popularity of microdosing reflects the need for alternative avenues to address mental health in an increasingly stressful world.

“Moms feel all of that, not only for themselves but also the humans they’re raising,” she said. “We’ve reached a point where we need a reset and I think a lot of people are discovering taking more and more pills passively over any number of years isn’t solving the problem.”

To that end, Tee said microdosing is unlike conventional medicine: “It’s not Advil, you don’t swallow it back and wait for it to change your life.”

It often requires introspection, reflection and a commitment to working through challenges that may arise, a process commonly called “integration.” For Montrose mom Bri Taylor, that included a lifestyle change. She stopped drinking alcohol and said microdosing makes her a more present parent for her two young sons.

For Monique Alvarez in Cortez, many of the benefits appeared in retrospect. After several months of microdosing consistently, she said she was able to tap into new sources of creativity.

“It’s easier to access better ideas, better solutions, and more innovative ideas. I’m able to see things from different perspectives. The dots are connecting in ways they haven’t before,” Alvarez said.
Up from the underground

Given the interest in microdosing, advocates see one important issue that still needs to be addressed: access.

When Colorado rolls out a legal industry around psychedelic therapy in 2025, microdosing won’t fit into that model, which focuses on giving people large quantities of psilocybin mushrooms for a guided trip. So right now and for the foreseeable future, the only legal ways to source microdoses are to grow your own mushrooms or find someone willing to share their stash.

Sharing and gifting have become more commonplace in Colorado since certain psychedelics were decriminalized. Ely, for example, frequently hosts informational sessions for small groups and sends attendees home with complimentary microdosing starter kits. She grows the mushrooms and makes microdosing capsules herself under the moniker Love On Telluride. She also offers mentorship to people who want it throughout their microdosing practice.

Denver was a leader in 2019 when the city effectively decriminalized “magic mushrooms,” inspiring a wave of similar efforts around the country. Oregon and Colorado are the only states to legalize psychedelic-assisted therapy so far, though several others are considering following suit.

As legalization has become a political talking point, Schaper at Microdosing Collective said regulators often fail to recognize the full scope of psychedelics’ potential by focusing on healing through large, so-called “macro-doses,” which have also attracted the bulk of research.

The organization, launched in 2022, is now concentrated on finding a way to offer more Americans safe access to microdosing. It’s starting in California, where lawmakers have attempted – and so far failed – multiple times to approve regulated psychedelic-assisted therapy programs.

Schaper said while models like those in Oregon and Colorado represent important progress, they are cost-prohibitive and do not reflect how Americans currently use or want to use psychedelics. The Microdosing Collective recently hired a lobbyist intent on educating policymakers in hopes one day anyone can buy microdoses like they would any other supplement.

“There’s a huge opportunity to help people with their mental health with microdosing psychedelics and making sure it’s not trapped in big pharma and also not trapped at the service centers,” she said.

Related Articles

Originally Published: August 19, 2024 

Wednesday, August 07, 2024

 August 7, 2024

Fake Jesus and Free Buffalo

 

Cover art for the book Prairie Edge by Conor Kerr

Despair and desperation. A history denied and misrepresented. A colonial legacy that still stains the lives and landscape. These describe the setting of Conor Kerr’s new novel Prairie Edge. Set in the Edmonton, Alberta area of Canada, its two primary protagonists are indigenous MetĂ­s young people angry and frustrated with a world that gives them little to no credit and even less hope. Cousins somewhat separated, they find themselves living in a single-wide trailer when the book begins. The young man in the story, nicknamed Ezzy, has lived a life moving from foster home to foster home. It is obviously not a life that excels at providing its inmates much of a future beyond the one that Ezzy is living. It is a life defined by drinking Lucky Lager and playing cribbage with his housemate and cousin Grey, a young woman dedicated to fighting for Native rights and against fossil fuel company destruction.

That is, until one night when the two steal a truck and move a small herd of bison from a park outside of town and let them loose in a down park in the city of Edmonton. The motivation behind the action seems straightforward: give the bison and what they represent a chance to thrive again in a world ever more rapidly dying. The results of the action are considerably more complicated. The media does its usual worst in defining the spectacle while the police fumble through their motions of asserting control. Protestsdefending the bison and opposing fossil fuel extraction and the denial of indigenous rights grow in size in the city. Neither results is much of anything. Meanwhile, Grey and Ezzy find another herd and attempt a similar release. This one doesn’t go as well. The bison are moved, but evidence is left behind. A boyfriend of Grey’s from the past appears and, just like he did earlier in Grey’s life, spins her head slightly and makes the protest his own. Not because he necessarily cares about the bison or the issues, but because he sees the protests as an opportunity for ego gratification. Grey seems to know better, but walks back down the path this man Tyler led her down once. Ezzy goes back to his old ways of drinking and drifting.

The story takes a series of brutal turns that result in Ezzy in the hospital with multiple fractures, Grey killing a man who tried to rape her and, ultimately, Ezzy strung out on painkillers given to him by the doctors at the hospital. The story ends on a low but honest note. 

Then there’s the idea that the modern world is merely a hyper-drive version of the madness inherent in the human condition. Religion and government, law and economics. It’s all nonsense designed to convince us that we have a purpose both as individuals and as a species. Ancient Babylon to Manhattan, animism to Catholicism; the show goes on only because we believe it must. Jesus was a savior for some when B.C. crossed over into A.D. For others, he was blasphemy. Today, it could be argued that his name is spoken more in vain than in any other conversational form. Cardinals and con men all claim to know his word while they turn that word into cash dollars and other coin. Men whose lives mirror the suppositions we have about Satan claim the mantle of the Lord Jesus Christ while lost souls blindly attach themselves to these men’s words and give them their votes and their bank accounts. In other words, religious faith is just another transfer of wealth from the working class to the wealthy.

This is the situation one discovers as they began John O’Kane’s hilariously hallucinatory new novel titled The Accidental Jesus. A man who looks like the white Jesus we’ve all been sold as the real thing arrives in the city of San Pedro for his high school reunion. At one time a Jock for Jesus, the fellow has let his hair grow, continued his interest in seeking spiritual wholeness and lives on a commune dedicated to that search with several others. After leaving the reunion festivities somewhat disillusioned—not unexpectedly—he decides to leave town, but not before checking out a couple old haunts. That’s when things get weird.

The escapades he describes are as innocent as a conversation about spirituality with a man living in an RV near a camp of the unhoused and as wild as an orgy of spiritual revolutionaries in a church. Bikers in a bar compete with bible-thumpers determined to crown the protagonist’s presence as the Second Coming just because he looks remarkably like the Jesus they’ve been sold. All the while, police and their military cohorts rain chemical from their copters and block off streets in an attempt to control the insanity unfolding all around them. O’Kane’s descriptions of the fictional events are simultaneously hilarious and crazed; I was reminded of the pages of a Watchman comic. Utterly unbelievable and quite believable all at once. This reader found the book humorous, beyond belief and wishing it was real, The Accidental Jesus is a psychedelic carousel ride fiddling with, ridiculing and challenging the concepts of religion, perhaps as part of a search for genuine meaning.

The current state of the US can perhaps be considered to be the sum of madness and tragedy. Trump’s involvement in US politics has turned a sideshow into a shit show. As noted before, religion is an obvious joke and the rich have those who make their profits convinced that the wealth of the wealthy is a benefit for them. Children look up to human mutations like Elon Musk because he’s rich and national armies commit genocide in slow and fast motion. These two new novels do a damn good job of portraying this state of affairs. Prairie Edge captures the state of depression too many humans consider normal. The Accidental Jesus reveals the madness that we know resides barely underneath the surface.

Ron Jacobs is the author of Daydream Sunset: Sixties Counterculture in the Seventies published by CounterPunch Books. He has a new book, titled Nowhere Land: Journeys Through a Broken Nation coming out in Spring 2024.   He lives in Vermont. He can be reached at: ronj1955@gmail.com