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Thursday, April 22, 2021

MAGIC MUSHROOM THERAPY IN CANADA

In February of 2018, Laurie Brooks, a 51-year-old nurse in Abbotsford, B.C., learned she had colon cancer. Next came radiation, chemotherapy and a surgery that removed an eight-centimetre-long tumour. But at her one-year surgery follow-up, her oncologist found that the cancer had metastasized. She had anywhere between six months and a year to live
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© Photo: Jackie Dives Laurie Brooks claims magic mushrooms helped with her anxiety.

Brooks and her husband, Glenn, who runs a home-renovation business, have four kids in their 20s. After the check-up news, she couldn’t sleep and cried constantly. She became withdrawn and felt anger at both the situation and at herself. At times she was gripped by an unshakable feeling that she had personally done something wrong. She feared having to inform her kids, for the second time, that their mother was dying. Soon she found that she couldn’t move her left arm—a psychosomatic side effect of her emotional distress. “I didn’t deal with any of the emotional stuff,” she says. “I just shoved that down inside while I got through the physical challenges of cancer.”


Then a family friend suggested a way she could find a measure of peace and deal with all that emotional stuff: take magic mushrooms.

In the last few years, an underground network of Canadian psychotherapists and medical practitioners, inspired by successful clinical trials, has helped patients gain access to psychedelics such as magic mushrooms, the gnarled fungi containing the naturally occurring chemical psilocybin. Many of those patients are terminally ill or are suffering from chronic depression or anxiety. They believe that psychedelics alleviate their suffering and help them get more in touch with their emotions. Psychedelics have been called the new cannabis—at least in Canada.

Brooks contacted a B.C. therapist who has helped other cancer patients experience magic-mushroom trips. Although she had never dabbled in mind-expanding drugs before, and was nervous, she wanted to spend what may be her final months living “authentically,” finding the self that was so often lost in her identification as a wife and mother and cancer patient.

Lying in a comfy bed and flanked by the therapist and a close friend, Laurie took three grams of magic mushrooms—a high dose guaranteed to send her on a trip. She’d prepared a mantra to guide her through the psychedelic experience. “Trust, be open and let go,” she told herself.

Before long, her mind opened into a realm of kaleidoscopic colours that she first found entertaining and then just a bit annoying. She next found herself pitched into a cold darkness. As she wrote in the notes she compiled post-trip, “It was like I was floating around in space but there weren’t any stars. It was just pitch black.”

At one point during her trip, while her hallucinations were peaking, Laurie visualized herself as a prisoner. “I saw myself in jail, with shackles on my wrists, and the shackles fell off, and the jail door slid open.” Brooks was free.

As the hallucinations subsided and she settled back into our shared, everyday reality, she realized she could move her left arm again. She swung it in wide circles.

In the recreational culture of psychedelics, users often talk about the “afterglow.” It’s a feeling of clarity or emotional well-being that persists after the drugs themselves have worn off. It’s like the opposite of a hangover. The sun seems warmer. You notice dew on each blade of grass glistening anew. Many patients only need to experience a magic-mushroom trip once to feel like the treatment was a success.

A year after her trip, Brooks was still glowing. “Everybody looks at me and says, ‘You don’t look sick at all!’” she reflects. “I don’t have all the fear and anxiety anymore.”
A long and controversial history

Before psychedelics like magic mushrooms gained notoriety in the 1960s as the preferred drugs of the Woodstock generation, ancient and Indigenous cultures prized them for millennia for the experiences they produced. Psychedelics induced states of consciousness with deep mystical and spiritual dimensions.

So-called “classical psychedelics”—a category that includes psilocybin, LSD, mescaline and a few configurations of dimethyltryptamine, or DMT—are psychologically powerful and spiritually potent. At the same time, they pose no real risk of addiction. Medical researchers believe that these drugs function by affecting the serotonin, a neurotransmitter that affects everything from mood to memory. The ceremonial and prehistorical use of these compounds has much to do with them being readily available in nature. That includes the bulbous and prickly peyote cactus, to DMT-containing “pink carpet” perennials native to South Africa, to the formidable Psilocybe azurescens mushrooms that peek up from the fertile soil of Oregon’s Columbia River Delta. LSD, meanwhile, is a chemical derivative of ergot, itself a fungal growth common on rye plants.

Scientists are now reassessing psychedelics as a promising therapeutic. In 2006, a team at Baltimore’s Johns Hopkins University led by neuropharmacologist Roland Griffiths demonstrated that psilocybin stimulated spiritual and deeply emotional experiences (comparable to the birth of a child or the death of a parent) in 30 volunteers. The resulting paper gave scientific heft to what generations of recreational users already knew: that psychedelics could facilitate profound (or “mystical-type”) experiences and lead to a shift in a user’s perception of themselves and their place in the world.

The therapeutic potential of such a revelation seemed limitless. Subsequent Hopkins research revealed that psilocybin could produce “substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer.”

This research spurred a psychedelic renaissance: a period of renewed clinical and recreational interest in these compounds. Writer Michael Pollan, prompted both by the Hopkins research and a nagging sense of emptiness in his own life, experimented with a range of psychedelics, which he wrote about in his 2018 bestseller How to Change Your Mind.

In the first episode of her Netflix series The Goop Lab, actor and wellness guru Gwyneth Paltrow dispatched her staff to a magic-mushroom ceremony at a Jamaican beach resort. And in late 2019, Canadian businessman Kevin O’Leary announced his investment in MindMed, a start-up using psychedelics to treat addiction. It’s one of several Canadian businesses trying to capitalize on the hype.
Therapy and bad trips

Canada has long played a central role in psychedelics research. The field of psychedelic therapy was pioneered at Weyburn Mental Hospital in the 1950s, under Dr. Humphry Osmond and Dr. Abram Hoffer. It was Osmond who, in a correspondence with novelist and mind-expansion aficionado Aldous Huxley, coined the word psychedelic, meaning, roughly, “mind-manifesting.”

In their earliest medical applications, psychedelics like psilocybin and LSD were used to induce states of temporary psychosis—in order to observe and understand those states.

These applications were not always well-intentioned, or even consensual. In the 1950s and ’60s, Montreal’s Allan Memorial Institute was the site of countless psychedelic trials that were overseen by Scottish psychiatrist Ewen Cameron, funded by the CIA and partially underwritten by the Canadian government as a means of exploring the potential of mind control.

In one case, the wife of a Manitoba MP sought Cameron’s help in treating postpartum depression, only to be unwittingly dosed with LSD and subjected to brainwashing tapes. (A group of these victims sued the CIA in the 1980s and won.)

Osmond and Hoffer’s work led to the idea that these potent hallucinogens could also be powerful therapeutic tools. Clinicians analyzed the effects of psychedelic drugs in treating everything from alcoholism to schizophrenia and arrived at a crucial conclusion: that a positive psychedelic experience, one that facilitated a profound and lasting change in the patient, relied significantly on a positive mental outlook and an encouraging environment. Treat patients like they’re mad and they’ll behave accordingly. Treat them like they’re sick, in need of healing, and that healing is more likely to occur.

Much of the ’60s-era panic around these substances centred on “bad trips,” in which a powerful drug produced a state of mental frenzy resembling psychosis. In one famous 1969 case, Saskatchewan-born radio host Art Linkletter’s 20-year-old daughter, Diane, jumped out a window—a death her dad attributed to LSD.

The association of psychedelics with the ’60s counterculture had a blowback effect on serious-minded clinical research. Erika Dyck, Canada Research Chair in the History of Medicine at the University of Saskatchewan, notes in her book Psychedelic Psychiatry how, as mind expansion moved from the clinic to the campus, “Medical authorities promoting psychedelic psychiatry were perceived as indirectly endorsing a cultural revolution.”
In 1968, LSD was added to Canada’s Narcotic Control Act, rendering both recreational and medical use illegal. In 1974, psilocybin was outlawed. Both LSD and psilocybin are now listed under Schedule III of Canada’s Controlled Drugs and Substances Act.


The doctor who believes magic mushrooms can help

More than anyone, Dr. Bruce Tobin is responsible for legitimizing psychedelics therapy in Canada today. He’s worked as a private psychotherapist for the last 35 years and is a former professor of child and youth care at the University of Victoria. He’s 73 years old, lanky and friendly, with a white beard and a wide smile framed by a messy mop of hair.

© Photo: Nik West Psychotherapist Bruce Tobin is leading experiments with psychedelic therapy in Canada.

Tobin was drawn to the field by the results of studies and clinical trials, especially those at Johns Hopkins. He struck up an informal alliance—a friendship, really—with some of the top researchers at the university. In January 2017, he filed a class-action exemption application with Health Canada for access to psilocybin for people who met specific criteria, in order to provide therapeutic treatments. He founded TheraPsil—a non-profit with five employees—in the fall of 2019 while waiting for that application’s results.

After that first application was denied, Tobin and his staff focused on bulking up scientific, evidence-based arguments for psilocybin. Then, they reapplied with individual applications focused on granting compassionate access to specific patients suffering from intractable end-of-life anxiety. Tobin was ready to take the case to the Supreme Court, and failing that, practise a little civil disobedience himself by joining the ranks of on-the-sly psychedelic therapists.

Then, to his surprise, the government approved the first batch of his patient applications last August. “My sense is that, initially, Health Canada hoped that by more or less ignoring my application, I’d go away,” Tobin says, speaking from his home just north of Victoria, in North Saanich. “I’m not going away.”

Tobin’s mission is personal. In his career, he’s watched as various pharmaceutical cure-alls passed in and out of fashion. He also saw his own mother struggle with depression and anxiety—pharmaceuticals only numbed or exacerbated the root causes of her pain. He calls psilocybin an “existential threat” to Big Pharma and daily regimens of prescription drugs. The treatment is safe, relatively inexpensive (versus a lifetime of pricey prescription drug renewals), the outcomes are better, and, in many cases, it need only be undertaken once. New studies from Johns Hopkins show that patients who took the treatment four years ago are still reporting the positive effects—the benefits of a long, long afterglow.

Tobin recommends psilocybin should only be taken after establishing a rapport between the patient and the therapist. “This isn’t an easy process, where you simply take a pill and the heavens open and you’ll have transcendent, mystical experiences,” he says. “In many sessions there is difficult emotional work to be done.”

Like any therapy, these sessions hinge on confronting repressed, buried or otherwise uncomfortable feelings. The hallucinations, in many cases, function as metaphorical mini-movies. Imagine being confronted by some terrifying monster, then defeating it. Or think of Laurie Brooks busting herself out of the prison of her own inhibitions.

While fanciful and conjured in the mind, such experiences feel deeply real to the patient. And with proper therapeutic guidance (often termed “integration”), these profound lessons can be carried over into waking life when the drug’s effect subsides.

The power of the experience is further attributed to its ability to stir these feelings in a relatively compact session. Psychedelic enthusiasts describe the experience as being like years of therapy condensed into six or eight hours. Tobin is quick to dismiss such hyperbole, but he admits there is a measure of truth in such proclamations. “The effect of the medicine,” he explains, “makes it such that a person is able to process a lot more material than is normally accessible to them in any ordinary state of consciousness.”

The exemptions granted by Health Canada allow select patients to possess and consume psilocybin. As with cannabis—which began its route to medical decriminalization and, eventually, legality, with a similar exemption—these end-of-life therapy applications are the thin end of the wedge.

Other research companies in Canada are already squeezing through the door Tobin cracked open, seeking exemptions to study the effects of psychedelics in treating everything from obesity to cluster headaches to treatment-resistant depression. Health Canada has recently granted further exemptions to clinical researchers and biotechnology companies, plus 17 licences to psilocybin producers that supply clinics and researchers. Therapists are also seeking exemptions to take the drug in their training, in order to gain a more robust understanding of the psychedelic experience they hope to one day administer.

“The science is swiftly moving,” says Tobin. “The therapeutic merits of psilocybin don’t just pertain to end-of-life issues.”

Tobin believes his scientific credibility helped his application in the eyes of the government. And it’s the continued provability of psilocybin’s benefits that seems likely to shape its expanded legal framework. For now, however, psychedelics are primarily used for one noble end: easing the fear of death in people with terminal diagnoses.
Making the last days better

On August 12, 2020, in Saskatoon, about a four-hour drive from the now-demolished Weyburn Mental Hospital, Thomas Hartle became the first Canadian since 1974 to legally consume magic mushrooms.

Hartle, a 52 year-old father of two who works as an IT technician, was diagnosed with stage four colon cancer in 2016. Treatments put the cancer in remission for a couple years, but it returned in the summer of 2019, along with emotional distress, anxiety and crippling panic attacks.

The chemotherapy also led to neuropathy, a form of nerve damage that can cause numbness and weakness in the extremities. Researching Hericium erinaceus, a stringy mushroom used in some Eastern medicine practices to treat nerve damage, Hartle stumbled across the Johns Hopkins research on psilocybin and end-of-life distress. His interest was piqued, though he remained a little incredulous. “My experience with psychedelics was strictly through books and the media,” he explains. “To me, psychedelics were a party drug that people used in the ’60s.”

Hartle’s exploratory googling also led him to TheraPsil. Last spring, he reached out, and they added him to their exemption applications. After a few lengthy phone calls and some introductory screening, Tobin flew to Saskatoon to spend some time with Hartle and his family and build the sort of trusting relationship that is integral to the success of any therapeutic process. While Hartle tripped behind an eye mask, safely ensconced in his bed and listening to calming music, Tobin kept watch, making sure everything was going smoothly and offering words of encouragement.

“Less is kind of more,” Tobin explains. “We don’t want to put ourselves into the picture. The more invisible I become, the better, so the patient can focus exclusively on their inner experience.”

I spoke to Hartle a few weeks after the trip, and just a day after he began a new round of chemotherapy. He remained irrepressibly chipper. Before Hartle’s psilocybin trip, Tobin administered a Hamilton assessment—a scale that rates anxiety. A score of 25 to 30 would mean moderate to severe anxiety. Hartle ranked 36. During the treatment, Tobin asked him to rate his anxiety again. Hartle reported a zero. No anxiety. The day after the trip, he scored a mere six points: mild anxiety, verging on nonexistence.

Hartle hasn’t suffered a panic attack since the treatment. He has become more open with people around him and even learned to view his chemo treatments with grace. “To be fair,” he confesses, “everything about chemotherapy does kind of suck. But as opposed to dwelling on it, I have just experienced it and let it go.”

It’s too soon to speculate on how the rush of investors will shape the next phase of this psychedelic renaissance. What’s becoming clear, through all the hype and hallucinatory reveries, is that for patients suffering from acute anxiety and end-of-life distress, psilocybin offers serious, long-lasting relief, making those last days more livable. For patients like Brooks and Hartle, there are still bad days. But, as Hartle himself puts it, in what could stand as a tag line for a whole new wave in psychiatric medicines, “The bad days are better.”

The post Magic Mushrooms May Help People with Terminal Cancer appeared first on Reader's Digest.

Monday, July 17, 2023

DECRIMINALIZE DRUGS
AOC and Crenshaw form unlikely team in bid to give troops access to psychedelic drugs

Michael Lee
FAUX NEWS
Sun, July 16, 2023

Reps. Alexandria Ocasio-Cortez, D-N.Y. and Dan Crenshaw, R-Texas, are forming an unlikely alliance, teaming up in a bid to allow troops access to psychedelic drugs.

"Psychedelics have shown so much promise," Ocasio-Cortez said of the effort, according to a report from the New York Daily News. "We desperately need the resources to treat PTSD, traumatic brain injury and depression. At least one in two PTSD patients cannot tolerate or do not respond adequately to existing treatments."

The progressive lawmaker's comments come as the military and Department of Veterans Affairs grapple with the growth of post-traumatic stress disorder in the ranks, an ailment that has doubled among veterans of Iraq and Afghanistan compared to Vietnam-era veterans. According to the VA and the Centers for Disease Control and Prevention, over 450,000 combat veterans have suffered from a some sort of traumatic brain injury between 2000 and 2021.


Rep. Dan Crenshaw and Rep. Alexandria Ocasio-Cortez

But new data suggest that unorthodox treatments with psychedelics help, leading Crenshaw and Ocasio-Cortez to form an unlikely alliance.

"This is a real wild coalition," Crenshaw, a Navy SEAL veteran who lost an eye in Afghanistan, said of his partnership with Ocasio-Cortez, according to the New York Daily News.

Crenshaw said the issue has personally touched him, recounting the stories of friends who have returned from war and were not cured of their aliments until they gained access to psychedelics, which are typically illegal in the United States.


Rep. Dan Crenshaw

"I was turned on to this issue because I had so many friends… who were going down to a specific clinic and doing ibogaine – one treatment of ibogaine would cure them," Crenshaw said.

The duo targeted this year's National Defense Authorization Act to introduce their proposal, managing to get a "watered-down version" of the bill they authored into the massive yearly legislation.

Crenshaw said House Speaker Kevin McCarthy, R-Calif., has promised the lawmakers to get a comprehensive version of the bill, which will include funding and clinical trials, in the legislation during meetings with the Senate to combine the two chamber's versions of the bill.


Rep. Alexandria Ocasio-Cortez

Meanwhile, Ocasio-Cortez called on veterans to apply pressure to the Senate to make sure the provision gains approval.

"I know the power of this community to rise up and make itself heard," Ocasio-Cortez said.


Saturday, January 20, 2024


New Jersey bill would legalize ‘magic mushrooms’ for medical, recreational use

2024/01/18
Psilocybin mushrooms stand ready for harvest in a humidified "fruiting chamber" in the basement of a private home on July 28, 2023, in Fairfield County, Connecticut. 
- John Moore/Getty Images North America/TNS

New Jersey lawmakers have introduced a bill that would make it the third state to legalize “magic mushrooms.”

Under the legislation, anyone 21 and older could consume or grow the mushrooms for medical or recreational purposes.

The bill would also expunge past and pending offenses involving the psychedelic drug.

The bill comes as Hackensack Meridian, one of the state’s largest healthcare providers, and U.K. biotechnology company Compass Pathways partnered to research a synthetic psilocybin treatment, according to NorthJersey.com.

The state health department would oversee licenses for facilities for production and sales. Those sites would not be allowed in residential neighborhoods or within 1,000 feet of a school.

Residents would also be allowed to grow their supplies own at home in limited amounts for personal use.

New Jersey’s state senate mulled over a similar bill last year, before it was pulled for revisions.

In 2020, Oregon used a ballot measure to become the first state to decriminalize psilocybin. Colorado followed suit in 2022. California lawmakers advanced legislation to do the same in 2023. The cities of Denver, Oakland, Seattle and Detroit have legalized the drug, too.

New Jersey previously legalized marijuana for recreational use in 2021 and sports betting in 2018.

Studies have shown that psilocybin — the naturally occurring chemical in psychedelic mushrooms that causes hallucinations — improves cognitive behavioral therapy for disorders like depression, anxiety, obsessive-compulsive disorder, post-traumatic stress disorder and even alcoholism.

© New York Daily News



Monday, October 23, 2023

Single dose of psilocybin reduces depression in phase 2 trial

Credit: Cannabis_Pic / Adobe Stock

OCTOBER 22, 2023

Can psilocybin serve as a uniquely powerful and long-lasting treatment for depression? Since the renaissance of psychedelic research emerged in the 2000s, a growing body of studies suggests that psilocybin can reduce symptoms of conditions like major depressive disorder, anxiety, and end-of-life distress.

The most intriguing findings center on dosage: Some studies suggest that a single dose of psilocybin can yield therapeutic benefits that last long after the drug’s hallucinogenic effects wear off, possibly even months after ingesting one dose.

A study recently published in JAMA sheds new light on the therapeutic potential of psilocybin for depression. The randomized, double-blind phase 2 trial, conducted between 2019 and 2022, investigated the effects of a single dose of synthetic psilocybin on people with major depressive disorder.

The researchers found that “a 25-mg dose of psilocybin administered with psychological support was associated with a rapid and sustained antidepressant effect, measured as change in depressive symptom scores, compared with active placebo.”

Here are some of the key takeaways:The recent study featured a sample size of 104 people and a longer follow-up period than many previous studies on psilocybin and depression.
The participants who received psilocybin showed significantly reduced depressive symptoms compared to those who received a placebo, though they also experienced more adverse events.

The improvements in depression were sustained over a six-week follow-up period.

“These findings add to evidence that psilocybin—when administered with psychological support—may hold promise as a novel intervention for [major depressive disorder],” the researchers noted.

The results are promising, though they come with a couple of caveats.
A closer look at psilocybin and depression

For the study, the researchers recruited a total of 104 adult participants with moderate to severe major depressive disorder. After participants were given time, if needed, to stop psychotherapy and taper off any antidepressant medications they were taking, the researchers randomly sorted them into two groups.

One group of 51 people were assigned to get a single dose of psilocybin. The other group of 54 participants were given a placebo: niacin, a B vitamin that causes your face to “flush.” (The idea is that this reaction might make it harder for people to tell whether they got the drug or the placebo.) At the start of the study, neither the researchers nor the participants were told who received the psilocybin. Also, participants were given multiple sessions of psychological support, including during the psilocybin (or niacin) experience.

The main goal of the study was not to see whether depression decreased while people were experiencing the effects of psilocybin but rather to track changes in depressive symptoms in both groups at various timeframes over a six-week follow-up period. To do that, the researchers measured participants’ scores on the Montgomery-Asberg Depression Rating Scale (MADRS), which assesses the severity of depressive episodes. The researchers also had participants complete the Sheehan Disability Scale (SDS), which measures how symptoms impair functioning in daily life.

Participants completed both scales before taking either the psilocybin or the placebo, referred to as their baseline score, and also at follow-up periods: 2, 8, 15, 29, and 43 days after dosing.

The results revealed a statistically significant difference between the two groups in terms of reduced depressive symptoms over the six-week period. The group that got psilocybin saw their MADRS scores decline by an average of 19.1 points, vs. 6.8 points in the placebo group

.
A chart from the study showing changes in depression symptoms over time in the psilocybin and placebo groups. Credit: Raison CL, Sanacora G, Woolley J, et al. Single-Dose Psilocybin Treatment for Major Depressive Disorder: A Randomized Clinical Trial. JAMA. 2023;330(9):843–853. doi:10.1001/jama.2023.14530

By day 43, 58% of participants in the psilocybin group demonstrated a sustained response (defined as a 50% reduction from their baseline score), compared to 20% of the placebo group.

Although a sustained response is a good sign that an antidepressant is effective, it’s not the same as sustained remission, where depressive symptoms drop into the “normal” range. (While a greater share of the psilocybin group did go into remission compared to placebo, the difference wasn’t statistically significant.)

When it came to safety and tolerability, the researchers wrote, “Psilocybin was generally well-tolerated, with most AEs [adverse events] being of mild or moderate severity and generally limited to the acute dosing period.” However: “psilocybin treatment was associated with a higher rate of overall AEs and a higher rate of severe AEs compared with niacin, with these severe AEs being known effects of psilocybin.”
Caveats and cautious optimism

It’s worth noting that not all participants stuck with the follow-ups. The placebo group had a higher dropout rate, with 44 of the initial 53 participants ultimately making it to the 43-day check-up. Meanwhile, all but one participant in the psilocybin group completed the study (one withdrew from the study due to a death in their family).

What explains the difference in dropout rates? It’s hard to say for sure, but one possibility is that people in the placebo group became less motivated to participate in the study because they knew they received niacin instead of psilocybin. This underscores what’s arguably the biggest problem with psychedelic research: complications with blinding.

To validate the therapeutic potential of any drug, researchers use randomized placebo-controlled trials, where some participants receive the drug while others receive a placebo. Ideally, this process is double blinded, meaning neither the participants nor the researchers know who received the drug until the study concludes. The goal is to minimize bias and ensure that any recorded effects are likely due to the drug itself and not participants’ or researchers’ expectations.

But psychedelics make blinding nearly impossible: If you take psilocybin — a hallucinogenic drug that radically alters your subjective experience of reality — you’re unlikely to mistake it for a B vitamin.

Expectation biases — whether in the participants, the researchers, or both — can also complicate psychedelic research. For example, people who agree to participate in studies on drugs like psilocybin, MDMA, or LSD might already have a strong belief that psychedelics can effectively treat mental health conditions.

“This is likely to lead to positive expectation (consciously, subconsciously or both) which is in turn likely to lead to improvements in symptoms after enrollment, regardless of the specific effects of the psychedelics,” noted a 2022 paper published in Psychopharmacology. “This effect also works conversely, in that positive expectations can fuel disappointment in trials of novel psychoactive medication when participants believe that they have been allocated to the placebo arm.”

Still, the results of the recent study are promising, and they add to a growing body of research showing that psilocybin and other psychedelics might possess therapeutic effects that can far outlast the trip experience itself. Considering that 29% of U.S. adults report having been diagnosed with depression at some point in their lives, it’s arguably well worth exploring how psychedelics might help ease the burden of mental health problems.

So far, Oregon and Colorado are the only US states that have legalized psychedelic-assisted therapy, though initiatives in a handful of other states — California, Connecticut, and New Jersey — have aimed to pass similar legislation. Earlier in 2023, Australia became the first country to legalize the prescription of psychedelics, including psilocybin, for mental health conditions.

This article was originally published by our sister site, Freethink.


Thursday, June 01, 2023

My grandfather hid the emotional toll of World War II from his family for decades

ALCOHOLISM RATES ROSE WITH THE RETURN OF WWII AND KOREA WAR VETS

Story by Chloe Melas • Yesterday - CNN

For decades after returning home from World War II, my grandfather did not talk about his wartime experiences.

Frank Murphy flew 21 perilous missions as a navigator of a B-17 for the Eighth Air Force’s 100th Bomb Group, nicknamed “the Bloody Hundredth.” The day his plane was shot down in 1943, two of the men in his crew died, and my grandfather considered himself lucky to have parachuted out of his burning aircraft and be captured by the Nazis.


My grandfather hid the emotional toll of World War II from his family for decades© Provided by CNNFrank Murphy, the grandfather of CNN's Chloe Melas, after he was captured and taken a prisoner of war by the Nazis in 1943. - Courtesy Murphy Collection

For the next 18 months, he would endure deplorable conditions as a German prisoner of war, take part in a harrowing death march in subzero temperatures and by the time US Gen. George S. Patton’s troops liberated him, he had lost over 50 pounds and was riddled with dysentery, pneumonia and lice.

Everyone could see the physical toll of war on his body, but we didn’t know about his invisible wounds.

That is until 2001, more than 50 years after returning home, when my grandfather wrote a memoir, “Luck of the Draw: My Story of the Air War in Europe,” for our family. He originally self-published the book for our family but as I got older, I felt his story needed to reach a wider audience. After several years of gathering his original materials and photographs, I partnered with St. Martin’s Press to release the book in February and it is now a New York Times bestseller.

In his book, he wrote, “I often wonder why Providence allowed me to survive when so many others did not.”

My mother and his other three children said that their dad never spoke about the war during their childhood. It wasn’t until my mom read his book that she truly knew what he had gone through.

Even my grandmother Ann, his wife of 50 years, told me that she did not even know that her soon-to-be-husband had been a prisoner of war until right before they were married.

What is PTSD?


Researching my grandfather’s time during the war, I’ve often wondered if he had post-traumatic stress disorder. I may never know whether he had PTSD or not — but in the 78 years since World War II ended, it’s so vital that the national conversation around this important topic is moving forward.


My grandfather hid the emotional toll of World War II from his family for decades© Provided by CNNFrank Murphy was shot down on his 21st mission while flying over Munster, Germany. Two of the men on his crew died that day.
- Courtesy Murphy Collection

It’s had different names throughout history. After World War I, it was “shell shock”; post-World War II it was known as “combat fatigue,” and after Vietnam it was called “post-Vietnam syndrome.” In 1980, the American Psychiatric Association officially recognized it as post-traumatic stress disorder, or PTSD.

Post-traumatic stress disorder “is a psychiatric disorder that may occur in people who have experienced or witnessed a traumatic event, series of events or set of circumstances. An individual may experience this as emotionally or physically harmful or life-threatening and may affect mental, physical, social, and/or spiritual well-being,” according to the American Psychiatric Association’s website. “Examples include natural disasters, serious accidents, terrorist acts, war/combat, rape/sexual assault, historical trauma, intimate partner violence and bullying.”

Do veterans have a brain injury?

Now professionals such as psychologist Shauna Springer and psychiatrist Frank Ochberg are advocating calling it post-traumatic brain injury.

“I refer to it as an injury because I’ve seen that there’s a biological component to being exposed to trauma as well as a psychological component that has always been with us,” Springer, chief psychologist at the Stella Center, told me. “And now I think we’re on the cusp of evolving the term further.”

Post-traumatic brain injury has always existed, Springer said, and people are finally talking about it.

“It’s kind of like saying that because the divorce rate was so much lower in previous generations that everybody had these great marriages,” she said, “but actually that was a factor of how much stigma there was about divorce and how dependent women were financially at that time without their own career options.”

Forty percent of medical discharges during WWII were for psychiatric conditions, most for combat stress, according to the National World War II Museum In New Orleans.

Veterans keep quiet about trauma

But veterans didn’t always mention their trauma when they came home from the war.

“When your grandfather and my grandfather served in World War II, they didn’t talk about it,” Paul Rieckhoff, founder and CEO of Iraq and Afghanistan Veterans of America, told me.

“They came home and too often, you know, their therapy was drinking,” he said. “There was a generation of folks who had tremendous trauma and pain, and that overflowed into their families in ways that we still can’t even quantify.”


My grandfather was in the infamous Stalag Luft III prison camp, where “The Great Escape” took place. In his memoir, he writes about going to bed hungry, freezing and terrified of never knowing when the war would end.

“A prisoner of war experiences real-time feelings of helplessness and you’re on-your-own that cannot be imagined unless you have been there,” my grandpa relates in “Luck of the Draw.”



Inside Stalag 7A where Frank Murphy was a prisoner of war during WWII
. - Courtesy Murphy Collection

“It is difficult to put into words the sense of powerlessness and vulnerability one experiences when standing completely defenseless before a formidable armed wartime enemy of your country, knowing that the entire might of the United States is of no benefit to you.”

I have his book to remind me, but it’s hard to imagine what else he must have gone through, and the struggles he went through alone, once he was back home.

How are veterans today?

With so many US troops fighting abroad in Iraq and Afghanistan over the past 20 years, the problems my grandpa faced haven’t gone away.

About 16 veterans commit suicide each day in the United States, according to a report by the US Department of Veterans Affairs. Asked for comment by CNN, the VA did not specify how many of those suicides were related to post-traumatic stress.

I became active in the fight for our veterans when I joined the board of directors for the National Museum of the Mighty Eighth Air Force near Savannah, Georgia, in 2015 in honor of my grandfather’s service.

I found allies in the cause when I joined the board, including former Texas Gov. Rick Perry. Perry, who has been a vocal supporter of our nation’s veterans, was a pilot in the Air Force before entering politics and eventually becoming the US secretary of energy. His father, like my grandfather, served in the Eighth Air during WWII.

“My instinct here is warriors are very proud, and showing weakness in any form has historically been frowned upon,” he told me.

Perry’s attention to the emotional toll of war became heightened when he met Navy SEAL Marcus Luttrell. Luttrell had just returned home from a harrowing experience participating in Operation Red Wings in Afghanistan in 2005. (It went on to become a best-selling book and a 2013 film starring Mark Wahlberg called “Lone Survivor.”) Perry and his wife took Luttrell into their home and got him the psychological support he needed.


Chloe Melas is shown with her grandparents, Ann and Frank Murphy, in Atlanta in1989.
(Courtesy Melas Family Collection) - Courtesy Melas Family Collection

Do psychedelic-assisted therapies help?


At same time, Perry was introduced to Amber and Marcus Capone, a couple who had started an organization called Veterans Exploring Treatment Solutions, or VETS, which provides resources, research and advocacy for US military veterans seeking treatment with psychedelic-assisted therapies.

They started the group after Marcus Capone returned home from multiple combat deployments in Iraq and Afghanistan and was having suicidal thoughts.

“He didn’t understand why he couldn’t get better,” Amber Capone said. “He was trying so hard. I just thought of our kids and them living the rest of their lives without a father and how this would impact generations to come, and I just thought, I can’t stop fighting for him.”

Six years later, VETS says it has provided funding for more than 700 veterans to get access to psychedelic treatments at centers outside the country due to issues with legalization.

This is one of the reasons Perry has devoted years to supporting veterans and bipartisan legislation for psychedelic therapy for veterans.

“I know this whole concept, Rick Perry’s name and psychedelics in the same sentence, five years ago I would’ve kind of looked at you and said, ‘What are you talking about?’ ” Perry told me. “But I know kids that were really sick that are now about as close to normal as you can get.”

The legalization of psychedelic treatments varies in the United States. Only a handful of states such as New York, California and Arizona have active legislation proposed to decriminalize plant-based hallucinogens, such as psilocybin, the active ingredient in “magic mushrooms,” and dimethyltryptamine, which is found in some plants used to brew ayahuasca.

While Oregon and Colorado are the only two US states to have decriminalized psychedelic mushrooms for those over 21, other states such as Texas and Maryland are conducting clinical trials with MDMA and ibogaine for those suffering from issues such as PTSD and depression.

Dr. David Rabin, a neuroscientist and board-certified psychiatrist, has been studying the effects of chronic stress on mental and physical health for nearly 20 years.

“We know that hugs feel good. We know that music makes us feel good if we like listening to our favorite songs, right? That is intuitive, but we don’t necessarily remember to breathe when we’re stressed out,” Rabin said.

“Psychedelic medicine is interesting because it works when it’s used properly,” he said. “It works as a therapy amplifier because it molecularly seems to do something in the brain that amplifies the neural pathways of safety that are set up by the therapeutic environment.”

Springer cofounded the Stella Center, a network of clinics that offer ketamine infusion therapy and dual sympathetic reset for those suffering from post-traumatic stress. Dual sympathetic reset is a procedure involving a local anesthetic injected next to a mass of sympathetic nerves in the neck called the stellate ganglion to help regulate an overactive sympathetic nervous system, according to Stella’s website.

“For some, it’s medication; for some, it’s a service dog,” said Rieckhoff of Iraq and Afghanistan Veterans of America. “And I think everybody’s got to figure out what their right prescription is to meet their unique situation.”

Another individual bringing resources to veterans and their families is ABC News journalist Bob Woodruff.

While reporting in the field in Iraq in 2006, Woodruff had a near-death experience that changed the course of his life. An improvised explosive device struck him and his cameraman, and Woodruff was subsequently kept in a medically induced coma for 36 days.

During his recovery, he and his wife, Lee Woodruff, were inspired to launch their nonprofit, the Bob Woodruff Foundation, after getting to know veterans who were dealing with the impact of hidden injuries such as traumatic brain injuries.

“I would say almost every American wants to do something for veterans who served, but many don’t really know exactly where that support should go because it’s very complicated,” Bob Woodruff said. “We just kind of help people who want to do something, find the right direction to help people.”

To date, the foundation says it’s invested over $124 million in these programs and has given over 585 grants to veterans and their families

As for the future, Perry said it’s about continuing the conversation.

“I think mental health is the most undiagnosed and unknown malady that we have in modern society, potentially,” he said. “It was there all along.”

Correction: An earlier version of this story misstated how long Bob Woodruff was in a medically induced coma and misstated the term “dual sympathetic reset.”


SEE




Sunday, July 29, 2007

Summer of Love


It is the fortieth anniversary of the Summer of Love, which led to a social revolution around the world. One that we are still experiencing and which the Right Wing loves to blame for all of modern societies ills.

Summer love-in summer -in

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Events nationwide mark the 40th anniversary of 'Summer of Love'

Events are being held around the country this summer to mark the 40th anniversary of the Summer of Love, when thousands of young people descended on San Francisco to experience the hippie counterculture in 1967. Here are some highlights.

Ongoing: ''Summer of Love: Art of the Psychedelic Era'' at the Whitney Museum of American Art in New York through Sept. 16. Through light shows, album covers, posters and music, the show explores the era's cultural impact. http://www.whitney.org .

Ongoing: Rock and Roll Hall of Fame and Museum exhibit dedicated to the 40th anniversary of the Monterey International Pop Festival. Highlights include telegrams from Jemi Hendrix, the Grateful Dead and The Who regarding their attendance at the festival; Paul Simon's guitar; the dress worn by Michelle Phillips of the Mamas and the Papas,and many pohotographs. The museum is in Cleveland, Ohio. http://www.rockhall.com .

Various dates: Jefferson Starship, Quicksilver Messenger Service, Big Brother and the Holding Company and other bands reunite for a Summer of Love 40th anniversary tour, including the Monterey Pop 40th anniversary festival at Monterey Fairgrounds, Monterey, Calif. http://www.genxentertainment.us .

Concludes today: Monterey Summer of Love Festival, featuring dozens of bands performing from the same exact stage as the 1967 Monterey Pop Festival. On stage: Riders on the Storm, Robbie Krieger's & Ray Manzarek's latest version of The Doors; Electric Flag; tributes to The Mamas and the Papas, and The Who. http://www.summer67.com .

American soldiers are fighting an unpopular war halfway around the world; peace groups protest and Congress is embroiled in a bitter, divisive debate.

At home, radios play the Doors, the Beatles, the Who and the Moody Blues. People flock to open-air concerts to see Eric Burdon and the Animals, Jefferson Airplane and Big Brother and the Holding Company. Concern grows for the environment and people feel good when they can buy organic food directly from growers.

It’s cool to get in touch with your feelings. Fashionable women wear flower power minidresses and empire-waisted tops. Jeans, of course, are everywhere. Is it 1967 or 2007? It’s both.

Forty years after the Summer of Love that signaled a seismic shift in our culture, many of the concerns and issues – even the looks – are back again.

And as for the areas where we’re not re-experiencing 1967 – the sexual revolution, the drug culture, the civil rights movement, the civil unrest – that’s because the subculture has now become the culture, says Robert J. Thompson, founding director of the Bleier Center for Television and Popular Culture at Syracuse University.

“Our entire lifestyle in the early 21st century significantly carries the genetic code of the revolutions and cultural and social changes in the late 1960s. And we don’t consider them at all revolutionary,” says Thompson.


Nineteen sixty-seven was when the journey began, but where, and when, did it end? Or has it? What really happened during those portentous few months of the Summer of Love that caused many of us to mutate physically, emotionally and spiritually? Did it really cause a seismic shift in the values, sensibilities and moralities of our culture, as many suggest? And are we still living in the afterglow of it intense culture-transforming heat?

Critics on the right would also like to deep-six the buzz about a better, happier time. A psychedelic Shangri-La. As the Chicago Tribune recently noted:

"In the nation's culture wars, the 1960s are a rallying cry for conservatives who view the decade as the source of social trends they oppose, such as a high divorce rate, legalized abortion and, more recently, the drive for same-sex marriage." (Strange, you make that sound like it's a bad thing.) For Jason Fine, deputy managing editor of Rolling Stone, "A lot of what happened in the summer of '67 wasn't about politics, or even antiwar, it was much more personal. And those kinds of developments have certainly stuck around. Our attitudes about sex, drugs and spirituality are all rooted in that time. That wasn't a blip."

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SEE:


A Little Eros For Valentine's Day


CIA Conspiracies Are Real


Psychedelic Saskatchewan


RAW RIP


420


Marx on Bigamy


Passover Song


Year of the Pig


Black and Redmonton


Celebrating Capitalism


Soul of a City


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Friday, February 04, 2022

Fish on acid? Microdosing zebrafish with LSD shows its potential benefits for humans
The Conversation
February 03, 2022

Zebrafish (Screen Grab)

Microdosing — regularly ingesting small amounts of a psychedelic substance 
— has gone mainstream.

Believed to increase productivity, spark creativity or improve open-mindedness, the microdosing of psychedelic drugs is gaining popularity with both academic researchers and those interested in experimenting.

But microdosing may offer more beyond its mood-boosting abilities.

Using zebrafish and our new method for precise and repeated drug administration, my colleagues and I are studying LSD and terpenes (chemicals in plants responsible for their scent, among other things) in a series of projects exploring potential novel treatments for mental illness and alcohol use disorder.

Zebrafish might seem an odd choice in studying human health, but they share 70 per cent of their genes with us and are a popular nonhuman organism used by scientists to study biological processes. They are also incredibly social, making them well-suited for behavioural studies into psychiatric disorders and drug discovery.

However, past drug research using zebrafish has studied “chronic” administration — putting fish in a drug solution for weeks. Since humans require (at the very least) some sleep, this administration can’t accurately reflect human consumption patterns.

Dose control


To address this limitation, we developed a new method to dose multiple fish accurately and efficiently for exact exposure times. By placing an insert into the housing tank, we can move groups of fish from their housing tank into a dosing tank for a precise dosing period, more closely mimicking the way that a person might consume drugs or alcohol.

To verify that this new dosing procedure could have behavioural and neurochemical effects, we completed a series of projects using our new method to examine the effects of alcohol and nicotine.

First, we tested the zebrafish with a daily moderate dose or a weekly binge-level dose of ethanol for three weeks. We found a significant difference in location preference in the daily moderate group compared to controls during a withdrawal period, which implies there were neurological changes.

Then we followed up with a study using lower doses for shorter periods of time. Here, we saw decreased boldness and increased anxiety-like behaviour during withdrawal from the highest dose (opposite to what is seen after an acute single-dose).

Similarly, testing the model using nicotine, we found again that acute doses decreased anxiety-like behaviour while repeated dosing led to an increase of anxiety-like behaviour during withdrawal.

For humans, having an alcoholic drink or a cigarette can decrease anxiety, and the inverse is observed in withdrawal. Our zebrafish model is consistent with this, which has given us confidence that we can test novel compounds with potential therapeutic effects in humans.


Researchers have been finding that cigarette and alcohol consumption has increased during the pandemic. These substances can reduce anxiety, but withdrawal from them can increase it.
(Shutterstock)

Potential therapies


Terpenes are a large and diverse group of aromatic compounds. They are responsible for the smell, taste and pigmentation of plants. Many terpenes — like those found in tea, lemongrass, cannabis and citrus fruits — have medical benefits.

We found that zebrafish acutely dosed with the terpene limonene (found in citrus fruit peels and cannabis) and myrcene (found in cannabis and hops), showed a significant reduction in anxiety-like behaviour. One observation that may be clinically significant is that — contrary to nicotine or alcohol — no negative effects were seen after repeated dosing for seven days, suggesting minimal to no addictive potential.

This study, alongside previous research, suggests that the terpenes limonene and beta-myrcene possess sedative and anti-anxiety effects that have potential as valuable therapeutic compounds for the treatment of a variety of mental health conditions.


There is a growing interest in microdosing psychedelics to increase productivity and spark creativity.
(Shutterstock)

Prairie psychedelic research

Some of the most influential research into psychedelics began in Saskatchewan in the 1950s. British-born psychiatrist Humphry Osmond used LSD and mescaline to treat alcoholism, with single doses showing a 50 to 90 per cent recovery rate over two years.

However, while Osmond saw success in large single-dose treatments, the acute administrations required continuous monitoring of the patient over the seven- to 15-hour “trip” to prevent any harm arising from impaired judgment. From a therapeutic perspective, this would be very time-intensive for clinicians, and is not feasible.

This is where microdosing comes in. With the potential to be easy and safe, we believe this pattern of exposure to be more therapeutically relevant, as doses are small enough to be safely self-administered with the proper guidance of a clinician.

Future knowledge


In our first study, we repeatedly microdosed our zebrafish with LSD. Using behavioural neuroscience tests to quantify locomotion, boldness and anxiety-like behaviour, we observed no impact on behaviour after 10 days of repeated dosing. Like with terpenes, this may suggest a lack of withdrawal symptoms or addictive potential, which is encouraging for clinically viability for use in humans.

Our current study examines the effects of LSD microdosing on the symptoms of alcohol withdrawal, which is a growing issue in Canadian health care.

In Canada, the negative effects of alcohol are widely felt. Fetal alcohol spectrum disorder remains the leading developmental disability in Canada, and alcohol harm is a top cause of injury and death. It costs Canadians billions of dollars in lost productivity, and is a burden on the health-care and judicial systems. Treatment and rehabilitation can be costly, time consuming and bogged down in lengthy wait times — if accessible at all.

Further research into other psychedelics, like psilocin (the psychoactive compound in psilocybin, or “magic mushrooms”), are also planned with the goal of providing scientific evidence to help determine whether these substances should be used in larger clinical trials in humans.

Psychedelics may provide assistance, but despite increasing evidence that LSD and psilocin are non-addictive and low risk, they remain highly restricted. Perhaps with more research and the continuing shift in public perception, we might yet again see LSD being used as a radical treatment for mental health and addiction.

Trevor James Hamilton, Associate Professor in Neuroscience (Department of Psychology), MacEwan University

This article is republished from The Conversation under a Creative Commons license. Read the original article.

SEE

Tuesday, January 31, 2006

Tune In, Turn On, Drop Out


This month marked the 100th birthday day of Albert Hoffman the discoverer of LSD.

Father of LSD recalls his famous bicycle trip


LSD inventor keeps on truckin' at 100 The drug was popularized by Timothy Leary, the one-time Harvard lecturer known as the “high priest of LSD,” whose “turn on, tune in, drop out” advice to students in the 1960s glamorized the hallucinogen. The film star Cary Grant and numerous rock musicians extolled its virtues in achieving true self-discovery and enlightenment.

But away from the psychedelic trips and flower children, stories emerged of people going on murder sprees or jumping out of windows while hallucinating. Heavy users suffered permanent psychological damage.

The United States banned LSD in 1966 and other countries followed suit.

Mr. Hofmann maintains that was unfair, arguing the drug was not addictive. He has repeatedly said the ban should be lifted so LSD can be used in medical research, and he took the drug himself, purportedly on an occasional basis and out of scientific interest, for several decades.

And it has been 58 years since LSD was discovered and applied to scientific and psychiatric assessment. LSD - My Problem Child by Albert Hofmann

LSD was studied extensively by Dr. Oswald from Weyburn, Saskatchewan. Boing Boing: Midcentury LSD Experiments at Canadian mental hospital Yep little old Saskatchwan.

Dr. Oswald had done earlier experimentations with mescaline which he had administered to the author Aldous Huxely.

Mescaline, LSD, Psilocybin and Personality Change

Oswald was a pioneer in LSD investigations, he was the originator of the term 'psychedelic'. The experiments conducted in Saskatchewan were the more positive aspect of LSD experimentation during the late fifties and early sixties.

Flashback: Psychiatric Experimentation With LSD in Historical Perspective

In the popular mind, d-lysergic acid diethylamide (LSD) research in psychiatry has long been associated with the CIA-funded experiments conducted by Ewen Cameron at the Allen Memorial Institute in Montreal, Quebec. Despite this reputation, a host of medical researchers in the post–World War II era explored LSD for its potential therapeutic value. Some of the most widespread trials in the Western world occurred in Saskatchewan, under the direction of psychiatrists Humphry Osmond (in Weyburn) and Abram Hoffer (in Saskatoon). These medical researchers were first drawn to LSD because of its ability to produce a “model psychosis.” Their experiments with the drug that Osmond was to famously describe as a “psychedelic” led them to hypothesize and promote the biochemical nature of schizophrenia. This brief paper examines the early trials in Saskatchewan, drawing on hospital records, interviews with former research subjects, and the private papers of Hoffer and Osmond. It demonstrates that, far from being fringe medical research, these LSD trials represented a fruitful, and indeed encouraging, branch of psychiatric research occurring alongside more famous and successful trials of the first generation of psychopharmacological agents, such as chlropromazine and imipramine.

During the 1950's and 1960's the Canadian Defense Department, and the American Defense department and the CIA funded LSD research on unsuspecting Canadian subjects. They also did joint secret studies of Biological Chemical warfare weapons on the citizens of Winnipeg, and as we are finding out now, Agent Orange tests on unsuspecting Canadian troops and citizens in Gagetown NB.

Bio-Chemical Warfare and You

The most infamous of the CIA LSD mindcontrol experiments was the work of Dr. Ewan Cameron, but he was not alone. McGill university was also implicated in the illegal and unethical treatment of prisoners and unsuspecting patients by psychiatrists using LSD as well as other behavioral modification drugs and techniques.

Canadian experiments

The experiments were even exported to Canada when the CIA recruited Albany, New York doctor Ewan Cameron, author of the psychic driving concept which the CIA found particularly interesting. In it he described his theory on correcting madness, which consisted of erasing existing memories and rebuilding the psyche completely. He commuted to Montreal every week to work at the Allan Memorial Institute and was paid $69,000 from 1957 to 1964 to carry out MKULTRA experiments there. The CIA appears to have given him the potentially deadly experiments to carry out since they would be used on non-U.S. citizens.

In addition to LSD, Cameron also experimented with various paralytic drugs as well as electroshock "therapy" at 30 to 40 times the normal power. His "driving" experiments consisted of putting subjects into drug-induced coma for months on end (up to three in one case) while playing tape loops of noise or simple repetitive statements. His experiments were typically carried out on patients who had entered the institute for minor problems such as anxiety disorders and postpartum depression, many of whom suffered permanently from his actions.

It was during this era that Cameron became known worldwide as the first chairman of the World Psychiatric Association as well as president of the American and Canadian psychiatric associations. Cameron had also been a member of the Nuremberg medical tribunal only a decade earlier.

Resources on Drug Experiments Performed by the US Government


Letter re: LSD experiments at Prison for Women, Kingston

bioethics

LSD TESTS KINGSTON PRISON FOR WOMEN 1960'S

The Canadian military funded LSD experiments on students and musicians in Montreal


Canada was the one country that was extensively doing scientific and psychiatric studies on LSD, and would later influence the American studies such as those Ken Kesey went through and documented in his novel One Flew Over the Cuckoo's Nest.

THE USE OF LSD IN THE TREATMENT OF ALCOHOLISM


In fact it was the CIA which popularized LSD in the research community and can be thanked for its becoming the popular hippie drug it would become. The Original Captain Trips

The CIA aghast at the result of its 'experiment' getting out of control later would plant phony LSD fear stories in the press of the day, Time Magazine in partiuclar, about how LSD caused people to stare at the sun and go blind or leap off buildings because they thought they could fly. The incidents may have occured, not during hippie Timothy Leary style 'trips', but when unsuspecting CIA agents had been drugged without their knowing it.

The CIA dropped LSD but continued to practice narcopolitics with guns and weapons for heroin exchanges begining with the Vietnam war and it still continues today. As well as later connections between the CIA and the Cocaine cartels in Latin America. The War on Drugs was really about the war on drugs NOT supplied by the CIA. Always has been.

The CIA and The Politics of Heroin

CIA Hawking Heroin in Baghdad?

And while Dr. Hoffman blames LSD's wayward travels as the popular Tune In , Turn On, Drop Out drug of the Leary hippie era, its scientific banishment was orchestrated deliberately by the U.S. government after MKULTRA and other CIA experiments on mind control proved failures, and the popularity of the drug was getting out of their control.

Scientific research using LSD had to be restricted if not outright banned to cover up the covert studies done by CIA funded psychiatrists or else the scientific community would find out that results of so called benign studies were something more sinister.

The effect of lysergic acid diethylamide(LSD-25) on perception with stabilized images


The Guardian reports on one of the original British scientists who studied LSD prior to the famous Timothy Leary psychedlic revolution, who wants to return to studying its impact on mental illness.

Re-opening doors of perception
Sarah Boseley reports on the psychiatrist who wants to reverse the taboo against using LSD to help troubled patients


The revival of the idea of studying the impact of LSD is because the British Home Secretary has called for an extensive review of the drug legislation in Britain.

Will Clarke go soft on LSD and Ecstasy?

Charles Clarke has ordered a sweeping review of drug laws which could lead to the effective downgrading of Ecstasy and LSD.

The Home Secretary, who caused fury by resisting demands to toughen the rules on cannabis, said the current system of classifying drugs could be torn up.

He is considering a new system which would take into account the 'social' consequences of each drug, including links to muggings and burglaries. Drugs are currently split into Class A, B and C.


In 1972 Canada like Britain plans to do today, did a comprehensive Royal Commission into the use of drugs. The Ledain commission is noted for its work around cannibis and the controversial reccomendation at the time, one that remains controversial, for the decriminalization of cannibis and recreational drugs. The study also included research on LSD.

Canada was the soul source of scientific experimentation on LSD and for access to LSD even after the U.S. banned it.

BC's Acid Flashback

Long before Timothy Leary and the Summer of Love, patients at Hollywood Hospital in New Westminster were being treated with LSD.

To Rick Doblin, New Westminster's Hollywood Hospital was a far-off place of myth and legend. It was 1972, and being a college student in Florida, he was keen to expand his mind. So he wrote to the hospital to see whether he could undergo its most famous treatment; a 12-hour trip into his consciousness, under the influence of pure Sandoz LSD.

"It was the only place left where you could have a guided LSD experience in a controlled setting," Doblin says. But the hospital told him it would cost $600, more than an 18-year-old could afford, and the trip never happened.

He never forgot about that hospital, though. After doing a PhD in public policy at Harvard, he became director of the Multidisciplinary Association for Psychedelic Studies, a Florida-based research group that designs experiments using mind-altering drugs in psychiatric therapy. Last month Doblin was in the news because the U.S. Food and Drug Administration had approved a MAPS-designed study using MDMA (better known as Ecstasy) for post-traumatic stress disorder. Now Doblin is helping create an experiment using LSD - which, like MDMA, was successfully used by therapists for years before it was outlawed. So he's set his sights once again on Hollywood Hospital - or at least the files for the thousands of patients who were treated there with LSD between 1957 and 1975

Canada remained a source of LSD for drug studies conducted in the late 1970's all were done on animals none on humans after the US Administration banned the scientific use of LSD.

DISAGGREGATION OF BRAIN POLYSOMES AFTER LSD IN VIVO Involvement of LSD-Induced Hyperthermia

RNA Synthesis in Isolated Brain Nuclei after Administration of d-Lysergic Acid Diethylamide (LSD) In Vivo



Today a new age of mind explorers, working in the computer enhanced virtual reality of the wired culture have re-discovered the positive uses of LSD. LSD: The Geek's Wonder Drug?

The earlier researchers like Dr. Timothy Leary and Richard Albert (Baba Ram Dass) who used LSD to open the doors of perception ( as Aldous Huxely refered to his experiences on a similar hallucinogen; mescaline) this generation of mind explorers has their work to build on and Dr. Leary's later interest in computers. What goes around comes around and goes around and comes around.

Todd Brendan Fahey made the Digital Leap at the close of 1994.

The synthesis of psychedelic drugs and the Internet has not been widely written of by the mainstream media, but Fahey and others believe the relationship to run deep.

John Perry Barlow remarked to Fahey, in an as-yet unpublished interview: "I'll go so far as to say, if the government succeeds in its War On (some) Drugs--if everyone who used marjiuana and LSD were to really be put in jails--America would not have an operational computer left."

This remark mirrors Timothy Leary's assertion, to Fahey in 1992, that "Steve Jobs and Steve Wozniak were barefoot, long-haired acid freaks" and that Bill Gates was known to use LSD while at Harvard.

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