Showing posts sorted by relevance for query PSYCHEDELIC SASKATCHEWAN. Sort by date Show all posts
Showing posts sorted by relevance for query PSYCHEDELIC SASKATCHEWAN. Sort by date Show all posts

Monday, January 16, 2023

Alberta’s new policy on psychedelic drug treatment for mental illness: Will Canada lead the psychedelic renaissance?


Erika Dyck, 
Professor and Canada Research Chair in the History of Health & Social Justice,
 University of Saskatchewan
THE CONVERSATION
Sun, January 15, 2023 

Psychedelics are being held up as a potential solution to the growing need for mental health treatment. But, magic mushrooms are not magic bullets.
 (AP Photo/Peter Dejong)

Patients in Alberta will now be able to legally consider adding psychedelic-assisted therapy to the list of treatment options available for mental illnesses.

Alberta psychiatrists and policymakers suggest that they are getting ahead of the curve by creating regulations to ensure the safe use of these hallucinogenic substances in a therapeutically supported environment. As of Jan. 16, the option is available only through registered and licensed psychiatrists in the province.

Alberta’s new policy may set a precedent that moves Canadians one step closer to accepting psychedelics as medicinal substances, but historically these drugs were widely sought out for recreational and non-clinical purposes. And, if cannabis has taught us anything, medicalizing may simply be a short stop before decriminalizing and commercializing.

Psychedelic drugs — including LSD, psilocybin (magic mushrooms), MDMA (ecstasy) and DMT (ayahuasca) — are criminalized substances in most jurisdictions around the world, but some people are suggesting it is time to re-imagine them as medicines. A few places are even considering decriminalizing psychedelics altogether, claiming that naturally occurring plants like mushrooms, even “magic” ones, should not be subject to legal restrictions.

In the wake of cannabis reforms, it appears that psychedelics may be the next target in the dismantling of the war on drugs. Canada made bold strides internationally with its widespread cannabis decriminalization, but are Canadians ready to lead the psychedelic renaissance?

Early psychedelic research


There is some precedent for taking the lead. In the 1950s and ‘60s, an earlier generation of researchers pioneered the first wave of psychedelic science, including Canadian-based psychiatrists who coined the word psychedelic and made headlines for dramatic breakthroughs using LSD to treat alcoholism.

Vancouver-based therapists also used LSD and psilocybin mushrooms to treat depression and homosexuality. While homosexuality was considered both illegal and a mental disorder until later in the 1970s, psychedelic therapists pushed back against these labels as patients treated for same-sex attraction more often experienced feelings of acceptance — reactions that aligned this particular approach in Vancouver with the gay rights movement.


Despite positive reports of clinical benefits, by the end of the 1960s psychedelics had earned a reputation for recreational use and clinical abuse. And, there was good reason to draw these connections, as psychedelic drugs had moved from pharmaceutical experimentation into mainstream culture, and some researchers had come under scrutiny for unethical practices.

Regulation and criminalization

Most legal psychedelics ground to a halt in the 1970s with a set of regulatory prohibitions and cultural backlash. In public health reports since the 1970s, psychedelics have been described as objects of unethical research, recreational abuse and personal risk including injury and even death.

Underground chemists and consumers tried to combat this image, suggesting that psychedelics provided intellectual and spiritual insights and enhanced creativity.

Most jurisdictions around the world criminalized psychedelics, whether for clinical research or personal experimentation. Indigenous and non-western uses of hallucinogenic plants of course stretch back even further in history, and these too came under legal scrutiny through a combination of colonial pressures to assimilate and a looming war on drugs that did not distinguish between religious practices and drug-seeking behaviours.

The return of psychedelics


At the moment, the next generation of scientific research on psychedelics still lags behind the popular enthusiasm that has catapulted these substances into the mainstream. 
(AP Photo/Peter Dejong)

In the last decade, regulations prohibiting psychedelics have started relaxing. The U.S. Food and Drug Administration has designated breakthrough therapy status to MDMA and psilocybin, based on their performance in clinical trials with post-traumatic stress disorder (PTSD) and treatment-resistant depression, respectively.

Health Canada has provided exemptions for the use of psilocybin for patients with end-of-life anxiety, and has started approving suppliers and therapists interested in working with psychedelic-assisted psychotherapy. Training programs for psychedelic therapists are popping up across Canada, perhaps anticipating a change in regulation and the current lack of trained professionals ready to deliver psychedelic medicine.

At the moment, the next generation of scientific research on psychedelics still lags behind the popular enthusiasm that has catapulted these substances into the mainstream. Celebrity testimonials and compelling patient accounts are competing for our attention.

Meanwhile, the growing burden of mental illness continues to overwhelm our health-care systems. Psychedelics are being held up as a potential solution. But, magic mushrooms are not magic bullets.
Beyond the medical marketplace

Historically hallucinogenic substances have defied simple categorization as medicines, spiritual enhancers, toxins, sacred substances, rave drugs, etc. Whether or not Health Canada, or the province of Alberta, reclassifies psychedelics as a bona fide therapeutic option, these psychoactive substances will continue to attract consumers outside of clinical settings.

Canada has an opportunity to take the lead once more in this so-called psychedelic renaissance. But, it might be our chance to invest in more sustainable solutions to harm reduction and ways of including Indigenous perspectives, rather than racing to push psychedelics into the medical marketplace.

Indigenous approaches to sacred plants are not only about consuming substances, but involve preparation, intention and integration, often structured in ritualistic settings that are as much about spiritual health as physical or mental health.

This cosmology and approach does not easily fit under the Canada Health Act, nor is it obvious who should be responsible for regulating or administering rituals that sit outside of our health-care system. These differences in how we might imagine the value of psychedelics is an opportunity to rethink the place of Indigenous knowledge in health systems.

We are well positioned to take a sober approach to the psychedelic hype, which has been driven in large part by financial interests, and consider what aspects of the psychedelic experience we want to preserve.

Now may be a good time to reinvest in our public institutions to ensure that psychedelics don’t simply become another pharmaceutical option that profits private investors. Instead, we have an opportunity with psychedelics to rethink how a war on drugs has harmed individuals and communities and how we might want to build a better relationship with pharmaceuticals.

This article is republished from The Conversation, an independent nonprofit news site dedicated to sharing ideas from academic experts. It was written by: Erika Dyck, University of Saskatchewan

Read more:

The real promise of LSD, MDMA and mushrooms for medical science

Psychedelic experiences disrupt routine thinking — and so has the coronavirus pandemic

Erika Dyck receives funding from Social Sciences and Humanities Research Council. She is a board member of the US not-for-profit Chacruna Institute for Psychedelic Plant Medicines.

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Tuesday, October 03, 2023

BETTER LIVING THROUGH CHEMISTRY
Psychedelics plus psychotherapy can trigger rapid changes in the brain − new research at the level of neurons is untangling how

The Conversation
October 2, 2023 


Psychedelic art (Shutterstock)

The human brain can change – but usually only slowly and with great effort, such as when learning a new sport or foreign language, or recovering from a stroke. Learning new skills correlates with changes in the brain, as evidenced by neuroscience research with animals and functional brain scans in people. Presumably, if you master Calculus 1, something is now different in your brain. Furthermore, motor neurons in the brain expand and contract depending on how often they are exercised – a neuronal reflection of “use it or lose it.”

People may wish their brains could change faster – not just when learning new skills, but also when overcoming problems like anxiety, depression and addictions.

Clinicians and scientists know there are times the brain can make rapid, enduring changes. Most often, these occur in the context of traumatic experiences, leaving an indelible imprint on the brain.

But positive experiences, which alter one’s life for the better, can occur equally as fast. Think of a spiritual awakening, a near-death experience or a feeling of awe in nature.


A transformative experience can be like a fork in the road, changing the path you are on.
Westend61 via Getty Images

Social scientists call events like these psychologically transformative experiences or pivotal mental states. For the rest of us, they’re forks in the road. Presumably, these positive experiences quickly change some “wiring” in the brain.

How do these rapid, positive transformations happen? It seems the brain has a way to facilitate accelerated change. And here’s where it gets really interesting: Psychedelic-assisted psychotherapy appears to tap into this natural neural mechanism.
Psychedelic-assisted psychotherapy

Those who’ve had a psychedelic experience usually describe it as a mental journey that’s impossible to put into words. However, it can be conceptualized as an altered state of consciousness with distortions of perception, modified sense of self and rapidly changing emotions. Presumably there is a relaxation of the higher brain control, which allows deeper brain thoughts and feelings to emerge into conscious awareness.


Psychedelic-assisted psychotherapy combines the psychology of talk therapy with the power of a psychedelic experience. Researchers have described cases in which subjects report profound, personally transformative experiences after one six-hour session with the psychedelic substance psilocybin, taken in conjunction with psychotherapy. For example, patients distressed about advancing cancer have quickly experienced relief and an unexpected acceptance of the approaching end. How does this happen?


Neuronal spines are the little bumps along the spreading branches of a neuron.
Patrick Pla via Wikimedia Commons, CC BY-SA


Research suggests that new skills, memories and attitudes are encoded in the brain by new connections between neurons – sort of like branches of trees growing toward each other. Neuroscientists even call the pattern of growth arborization.

Researchers using a technique called two-photon microscopy can observe this process in living cells by following the formation and regression of spines on the neurons. The spines are one half of the synapses that allow for communication between one neuron and another.

Scientists have thought that enduring spine formation could be established only with focused, repetitive mental energy. However, a lab at Yale recently documented rapid spine formation in the frontal cortex of mice after one dose of psilocybin. Researchers found that mice given the mushroom-derived drug had about a 10% increase in spine formation. These changes had occurred when examined one day after treatment and endured for over a month.




Tiny spines along a neuron’s branches are a crucial part of how one neuron receives a message from another. Edmund S. Higgins



A mechanism for psychedelic-induced change


Psychoactive molecules primarily change brain function through the receptors on the neural cells. The serotonin receptor 5HT, the one famously tweaked by antidepressants, comes in a variety of subtypes. Psychedelics such as DMT, the active chemical in the plant-based psychedelic ayahuasca, stimulate a receptor cell type, called 5-HT2A. This receptor also appears to mediate the hyperplastic states when a brain is changing quickly.

These 5-HT2A receptors that DMT activates are not only on the neuron cell surface but also inside the neuron. It’s only the 5-HT2A receptor inside the cell that facilitates rapid change in neuronal structure. Serotonin can’t get through the cell membrane, which is why people don’t hallucinate when taking antidepressants like Prozac or Zoloft. The psychedelics, on the other hand, slip through the cell’s exterior and tweak the 5-HT2A receptor, stimulating dendritic growth and increased spine formation.

Here’s where this story all comes together. In addition to being the active ingredient in ayahuasca, DMT is an endogenous molecule synthesized naturally in mammalian brains. As such, human neurons are capable of producing their own “psychedelic” molecule, although likely in tiny quantities. It’s possible the brain uses its own endogenous DMT as a tool for change – as when forming dendritic spines on neurons – to encode pivotal mental states. And it’s possible psychedelic-assisted psychotherapy uses this naturally occurring neural mechanism to facilitate healing.

A word of caution


In her essay collection “These Precious Days,” author Ann Patchett describes taking mushrooms with a friend who was struggling with pancreatic cancer. The friend had a mystical experience and came away feeling deeper connections to her family and friends. Patchett, on the other hand, said she spent eight hours “hacking up snakes in some pitch-black cauldron of lava at the center of the Earth.” It felt like death to her.

Psychedelics are powerful, and none of the classic psychedelic drugs, such as LSD, are approved yet for treatment. The U.S. Food and Drug Administration in 2019 did approve ketamine, in conjunction with an antidepressant, to treat depression in adults. Psychedelic-assisted psychotherapy with MDMA (often called ecstasy or molly) for PTSD and psilocybin for depression are in Phase 3 trials.


Edmund S. Higgins, Affiliate Associate Professor of Psychiatry & Family Medicine, Medical University of South Carolina

This article is republished from The Conversation under a Creative Commons license. Read the original article.


Friday, October 13, 2023

How the religiously unaffiliated are finding purpose and spirituality in psychedelic churches

Are psychedelics the answer to addiction and depression?

October 11, 2023

More and more surveys point to decreasing membership in religious institutions and a corresponding rise of “nones.” Many people might assume that this indicates the absence of belief or a lack of spirituality.

Particularly in the West, people tend to think about religion in terms of belief in a higher power, such as God. For many nones, however, spirituality does not need a god or the supernatural to address questions of purpose, meaning, belonging and well-being.

While abandoning mainstream religious affiliation, many turn to alternative expressions, including secular, atheist and psychedelic churches.

For about a decade, as a scholar who studies alternative expressions of spirituality, I have tracked these groups online, visited churches and interacted with attendees. At times, I have been able to attend services or simply visit locations. At other times, out of respect for participants, I have met members – but not during services and rituals.

These churches demonstrate not a rejection of religion, as surveys suggest, but continued interest in spiritual community, rituals and virtues.

Psychedelic churches

One such church is The Divine Assembly, or TDA, in Salt Lake City, Utah. Founded in 2020 as “a magic mushroom church” by Steve Urquhart, a former member of The Church of Jesus Christ of Latter-day Saints, TDA conducts worship that connects people without dogma or intermediaries. TDA is not atheistic but maintains an inclusive notion of belief regarding God or a higher power.

Where members depart from traditional notions of religion and church, however, is within their practices and aims. Through psychedelic drugs, members believe they can directly experience the divine – as they define it – while gaining insight into their own and others’ well-being. Within the church, members participate in collective meaning-making rituals that fortify their everyday lives.

Distinctly, using psilocybin is not part of these activities, nor are instructions provided on conducting mushroom ceremonies. This is done on one’s own time, according to individual practices.

Through the church, members participate in practices to help cultivate the value of psychedelic exploration. These include a range of activities, from ice baths to meditation in a room with flashing lights. TDA also offers courses on growing psilocybin through its educational initiative “shroomiversity.”

To borrow from its stated mission, TDA works to connect “people to self, others and the Divine.” It also seeks to “protect responsible and religious use of psilocybin, and cultivate health and healing.” This mission does not deny the place of belief but highlights broader therapeutic concerns.

Through shared rituals, members cultivate community while enhancing their total well-being.


The Magic Mushroom Church.


Mushroom churches: an American tradition

Louisville, Kentucky’s Psanctuary Church brings “people together for healing and connection to divine revelation through communion with sacred mushrooms.” Nondenominational, Psanctuary defines itself as a “Constitutional Church.”

Indicating their legal status as a a nonprofit, tax-exempt, faith-based organization, Psanctuary situates itself as a uniquely American religion. For Psanctuary and other psychedelic churches, the use of psychedelics is simultaneously a sacred right and an expression of political freedom.

As with many psychedelic churches, Psanctuary is not atheistic. It understands divinity as “pure consciousness” that “permeates all being.” Positioned this way, religion moves away from monotheistic understandings of God.

Instead, it follows non-Western, indigenous and New Age understandings that view divinity as within everyone. It also reorients people from seeking salvation in a world to come by encouraging focus on the present.

Like TDA, religion for Psanctuary expresses the pursuit of “pure consciousness” as “the origin of health and well-being.” By experiencing this origin through psychedelics, members are “empowered to discover our own divinity.”

This dual emphasis on self-divinity and healing reflects common themes across psychedelic churches.

The Church of Ambrosia and Zide Door

Inspired by The Church of Ambrosia, a nondenominational, interfaith religion, Zide Door in Oakland, California, supports “the safe access and use of Entheogenic Plants.” Founded in 2019 by Dave Hodges, Zide Door affords space for members to “explore their spirituality.”

Commonly, mainstream religion requires believers to interact with the sacred through designated leaders or texts. At Zide Door and other psychedelic churches, the emphasis is on self-realization and interconnection through direct experience.

Psychedelics offer members firsthand access to religious understanding. Church, accordingly, becomes a place to support individual awakening.

Sacred Garden Community captures this shift. Also located in Oakland, SGC – as it announces on its website – is a “post-modern church” based on “faith of least dogma.” Through psychedelic sacraments, SGC claims to facilitate “direct experience of and relationship to Divine presence for individuals and community.”

Beyond the experience, SGC helps members integrate “the benefits” the “experience and relationship can bring” into everyday life. Like other psychedelic churches, SGC highlights how rejection of conventional religion is often accompanied by new avenues to pursue spirituality.

Ayahuasca churches and healing



A participant at an ayahuasca ceremony at a Hummingbird Church retreat in Hildale, Utah, in October 2022.  AP Photo/Jessie Wardarski

Ayahuasca churches rely on indigenous understandings of ayahuasca, a plant-based psychedelic brew. For Indigenous people of South America, ayahuasca is a sacred rite based on local knowledge. They argue that removing ayahuasca from that context takes away its power and impact.

Indigenous practitioners and scholars thus warn about both the appropriation and commodification of indigenous practices. While such concerns should not be ignored, ayahuasca churches tell us much about contemporary religion.

The turn to ayahuasca rituals highlights the growing connection between spiritual needs and healing. The emergence of ayahuasca churches in the U.S. suggests that such healing requires the support of community.

California-based Hummingbird Church, for example, draws from ayahuasca rituals to provide “participants with opportunities to recharge their body, mind and soul with positive energy and reconnect with themselves.” Its “Statement of Faith” emphasizes this commitment to holistic healing.

It also situates the divine in “earthly” terms. Members, they believe, “should seek within Nature that which is contributory to our health and well-being.”

Located in Orlando, Florida, members of Soul Quest Ayahuasca Church of Mother Earth believe likewise. As members contend, “What is of the Earth is our holy sacrament.” Like others, they position psychedelics “as tools” that benefit “physical health, spiritual growth, and personal evolution.”

Through ayahuasca, members of both churches see psychedelic rituals as aiding in individual rejuvenation. Once rejuvenated, members believe they help restore nature or assist in another’s healing.


Well-being as spirituality

Collectively, these churches demonstrate not a rejection of religion, as the term “none” might suggest, but an embrace of well-being as spirituality.

And while they are distinct in many ways, they also share some common goals: They seek to provide members and practitioners ways to heal emotionally, psychologically and spiritually.

A key lesson members connect to psychedelics is the intrinsic sacredness of each person: The divine is not elsewhere but within everyone.

To be a none might reflect one’s total rejection of supernatural belief. But as psychedelic churches illustrate, identifying that way can also indicate spiritual pursuits that refuse to fit nicely within traditional religious categories.

Morgan Shipley, Foglio Endowed Chair of Spirituality & Associate Chair of Religious Studies, Michigan State University

This article is republished from The Conversation under a Creative Commons license. Read the original article.

Sunday, November 12, 2006

Psychedelic Saskatchewan


There are series of new academic papers and a documentary film published by U of A researcher Erika Dyck on the Weyburn Saskatchewan LSD experiments done in the fifties and sixties.

LSD finds new respectability

Old research on LSD treatment for alcoholism gets new look ...

LSD & Alcoholism Treatment: Saskatchewan Alcoholism Treatment with LSD

'Hitting Highs at Rock Bottom': LSD Treatment for Alcoholism

Long-forgotten LSD treatment might aid alcoholics start a trip to recovery



The Weyburn experiments along with later research by Leary, Albert, etc. proved LSD was a useful and safe drug.

It had to be safe or of course the CIA would never have used it. However the CIA planted stories in the press about LSD suicides, LSD users going blind staring at the sun, all of which were fictions like WMD in Iraq.

In Canada and the US counter studies were used to 'prove' LSD was harmful. Of course as most LSD users and researchers know it is all about the 'setting'. If you are in a secure comfortable setting you have a good trip. Being strapped down and tortured of course would create a bad trip.

The Saskatchewan results were soon attacked by institutions including the Toronto-based Addiction Research Foundation. It argued Osmond's research, in which subjects were given LSD in comfy surroundings and stimulated with art or music, was poorly designed and proved nothing. In contrast, the foundation sometimes blindfolded or restrained its LSD test subjects to isolate the effect of the drug. It failed to reproduce the Saskatchewan results, a finding that, combined with growing social concern about LSD, eventually led to the end of research into such therapy.

Well of course they failed, they deliberately did not use empirical research to 'duplicate' the experiment. They used a different technique, one closely resembling torture, to disprove the Weyburn experiments. They of course had an agenda, one that was anti-LSD and thus anti-scientific.



See:

LSD





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Monday, August 07, 2023

 

Exploring what happens in the brain under the influence of psychedelics, while meditating and during hypnosis

Exploring what happens in the brain under the influence of psychedelics, while meditating and during hypnosis
Psilocybin, LSD, hypnosis, and meditation each induce distinct changes in 
rs-fcMRI. Paired t-tests were conducted to compare intervention vs. control for
 each ASC intervention method: (A) psilocybin (N=23), (B) LSD (N=25), 
(C) hypnosis (N=30), and (D) meditation (N=29). (A-D) Center shows the cluster 
pairs that survived connection thresholding (p<0.05 TFCE type I error protected).
 Red = increased connection between cluster pairs induced by intervention vs. 
control, blue = decreased connection between cluster pairs induced by
 intervention vs. control. Opacity of the connections is scaled according to the 
TFCE statistics for visual clarity. For further details about each cluster see
 Table S6, Table S7, Table S8, Table S9. The three brain images at the bottom of
 each panel depict the same ROI-to-ROI results in the sagittal, coronal, and axial 
planes. Network abbreviations: DAN = dorsal attention, sLOC = superior lateral 
occipital cortex, Cereb Crus = cerebellar crus, FPN = fronto parietal, Lang = 
language, ITG = inferior temporal gyrus, l/a/p DMN = lateral/anterior/posterior 
default mode, aPaHC = anterior parahippocampal cortex, STG = superior 
temporal gyrus, Som. Motor = somatormotor. r/l denotes both the left and right 
hemispheres. 
Credit: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging (2023). 
DOI: 10.1016/j.bpsc.2023.07.003

Changes in a person's "normal" mental state after taking drugs, while meditating, during hypnosis or due to specific medical conditions have been a topic of study for several years now. Some of these mental changes, which are known as altered states of consciousness, have been found to have potentially beneficial effects, reducing stress and fostering greater well-being.

Researchers at University of Zurich's Psychiatric Hospital have recently been exploring the potential of  drugs, such as psilocybin and  (LSD) for treating depression and other . In a recent paper published in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, they compared the brains of people who had taken psychedelics to those of others who were meditating or were hypnotized.

"Our group has plenty of experience studying altered states," Nathalie Rieser, one of the researchers who carried out the study, told Medical Xpress. "We have been investigating the effects of psychedelics on the brain in , given that altered states of consciousness are becoming increasingly relevant in the treatment of psychiatric disorders. Anecdotally, people often report similarities in experiences induced by hypnosis, meditation, or psychedelics. However, our neurobiological understanding of these states is only just evolving."

While many studies looked at individual altered states of consciousness and how they manifest in the brain, comparisons between these states remain scarce. Rieser and her colleagues wished to fill this gap in the literature, by comparing the neural correlates of psychedelics, meditation and hypnosis.

"We did not know if the same neurobiological alterations give rise to the experience of all altered states or whether these states are different on a brain-level," Rieser said.

Rather than conducting a single experiment that collectively involved psychedelics, meditation and hypnosis, the researchers analyzed datasets conducted during four distinct experimental trials. The first two trials examined the effects of two different psychedelic drugs on the brain, namely psilocybin and LSD, while the last two focused on hypnosis and meditation.

Exploring what happens in the brain under the influence of psychedelics, while meditating and during hypnosis
Pharmacological vs. Non-Pharmacological ASC Interventions. (A) A 2x2 mixed ANOVA with 
a between-subjects factor of ASC intervention method (pharmacological (Ph) vs. 
non-pharmacological (N-Ph)) and a within-subjects factor State (intervention vs. control) 
was conducted. Pharmacological interventions (N=48) include psilocybin and LSD; 
non-pharmacological interventions (N=59) include hypnosis and meditation. Center shows
 the 22 cluster pairs that survived connection thresholding (p<0.05 TFCE type I error 
protected). Red = increased connection between cluster pairs induced by pharmacological 
vs. non-pharmacological interventions, blue = decreased connection between cluster pairs
 induced by pharmacological vs. non-pharmacological interventions. Opacity of the 
connections is scaled according to the TFCE statistic for visual clarity. The 132 ROIs used 
are arranged into 22 networks, and the relevant networks are displayed on the outer ring. 
The three brain images in the right column depict the same ROI-to-ROI connectivity results
 in the sagittal, coronal, and axial planes. For further details about each cluster see Table 
S10. (B) Confusion matrix showing the predicted vs. the true classifications of subjects'
 intervention vs. control ROI-to-ROI connectivity matrices into either pharmacological or 
non-pharmacological interventions. Green = correct predictions, red = incorrect predictions. 
(C) Model predictions per subject (as we used a leave-one-subject out cross-validation
 scheme each fold represents an individual subject). The y-axis shows each subject grouped 
by ASC intervention method. The x-axis shows whether the subjects were classified as havin
g undergone the pharmacological intervention (negative function value), or 
non-pharmacological condition (positive function value). 
Credit: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging (2023).
 DOI: 10.1016/j.bpsc.2023.07.003

"We combined four different datasets that were collected at the Psychiatric University Hospital in Zurich using the same MRI-scanner," Rieser explained. "For the psychedelic studies, we included healthy participants who subsequently received psilocybin, LSD, or a placebo, whereas the meditation and hypnosis studies were conducted with participants who were experts in the respective field to make sure they can reach the state in an MR environment."

During the team's four experimental trials, all participants were asked to simply lay inside an MRI scanner without completing any task or engaging in any activity. The MRI scanner recorded their brain activity both while they were in a normal state of consciousness and under the altered state of consciousness relevant to that trial (i.e., after taking psychedelics, while meditating or while under hypnosis).

"We analyzed the participants' brain activity throughout the whole brain and investigated whether different brain areas work together in a distinct way compared to the baseline scan," Rieser said. "Our findings showed that even though psilocybin, LSD, meditation and hypnosis induce overlapping subjective effects, the underlying brain changes are distinct."

The findings gathered by this team of researchers suggest that while some might report having similar experiences or feelings under these different states of consciousness, what is happening in their brain is actually very different. While psilocybin and LSD appeared to produce similar , the changes they induced were markedly different from those observed during meditation or hypnosis. This suggests that psychedelics,  and  have distinct underlying mechanisms of action and overall different effects on the brain.

Overall, these results suggest that these three distinct states may have synergistic therapeutic effects and may not therapeutically substitute each other. In the future, they could pave the way for further investigations of their unique strengths and benefits, potentially informing the development of new promising therapeutic strategies for psychiatric disorders.

"We are now simultaneously working on investigating mechanisms of action of psychedelics in healthy controls as well as their  in the treatment of patients with alcohol use disorder and major depressive disorder," Rieser added. "We are assessing their efficacy and exploring , behavioral, and cognitive changes in response to psychedelic-assisted therapy. The current study is informing future investigations on optimizing psychedelic-assisted therapy."

More information: Flora F. Moujaes et al, Comparing neural correlates of consciousness: from psychedelics to hypnosis and meditation, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging (2023). DOI: 10.1016/j.bpsc.2023.07.003


© 2023 Science X NetworkPersonal psychedelic use may be common among psychedelic therapists


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Wednesday, May 31, 2023

Using psychedelics for depression is exciting area, says UK ex-vaccines chief


Kate Bingham, who chaired UK’s Covid vaccine taskforce, tells Hay festival she hopes mind-altering drugs could treat mental illness

Kate Bingham says data about the therapeutic use of psychedelic drugs has improved. 
Photograph: David Levenson/Getty Images

Lucy Knight
THE GUARDIAN
Mon 29 May 2023 

The former chair of the UK’s Covid vaccine taskforce has described the use of psychedelics to treat depression as an “area of real excitement” in a talk at the Hay literary festival in Wales.

Speaking at a panel event alongside the UK government’s former chief scientific adviser Sir Patrick Vallance, Kate Bingham said she was hopeful that the drugs could have a positive impact on mental ill health.

When asked by an audience member whether his 107-year-old grandmother, who has had depression for the last seven years, would benefit from psychedelic drugs or ecstasy, Bingham responded that “there is strong data now showing that different interventions can have effects on depression and mental health”.


The challenge so far when it comes to psychedelics, she said, is that “it’s been quite difficult to disassociate the trip from the actual reset of your mental health”. If such drugs were to be prescribed for depression, it would therefore be difficult to regulate, she added.

“How do you regulate psychedelics so they can be given safely to the over-85s or the young adolescents who are in a really bad way?” asked Bingham, though she added that she thought the research would “come through”.

Vallance said: “I don’t think you can slip your grandmother an ecstasy tablet. We’ve got to test these things.

“One of the really shocking things is how few people are in clinical trials,” he added. The Covid Recovery trial, which Vallance said was “the best study in the world for looking at interventions at its peak”, had about 11% of all Covid patients in UK hospitals on a clinical trial. “That is about 12 times more than you have for most diseases, when you have about 1%.”


Will psychedelic drugs transform mental health treatment? – podcast

“That can’t be right,” he said. Whatever you are testing he added, whether it is the possibility of treating depression with psychedelics or anything else, “the healthcare system needs to be much more geared towards testing these things properly, gaining answers as quickly as possible”.


Earlier this month, a number of psychiatrists and mental health charities wrote to the government calling for a change in legislation regarding psilocybin, the active compound in magic mushrooms.

The campaigners, which included the charity Campaign Against Living Miserably (Calm), think it should be legal for the drug to be used on the NHS and in medical research.

According to research published in April 2022, psilocybin could be helpful for those with treatment-resistant depression. Professor David Nutt, the head of the Imperial Centre for Psychedelic Research, said at the time that the findings showed that psilocybin “works differently from conventional antidepressants, making the brain more flexible and fluid, and less entrenched in the negative thinking patterns associated with depression”.


The big idea: should doctors be able to prescribe psychedelics?

However, since psilocybin is both a class A drug and a schedule 1 drug (it is classed as having no therapeutic value) it is difficult for researchers and medical professionals to access it.

The call to reduce restrictions was backed by a cross-party group of MPs and was debated in the House of Commons on 18 May. MPs agreed that “an evidence-based approach is required in order for parliament and the government to pursue the most effective drugs policy in the future” and called on the government “to conduct an authoritative and independent cost-benefit analysis and impact assessment of the Misuse of Drugs Act 1971 and to publish the results of those studies within the next 12 months.”







Friday, February 04, 2022

The struggle to define psychedelics

Psychedelics
Credit: Wikipedia

Psychoactive drugs include all manner of hallucinogens, deliriants, hypnotics and psychedelics. But what is a psychedelic, really? Insofar as many in the field are now moving toward bringing new molecules with presumably desirable introspective properties into a larger, potentially druggable populace, there is a palpable need for increased clarity.

There is a curious push to define psychedelics as compounds that alter consciousness by acting on serotonin  in the brain, most notably 5-HT2A receptors. However, that is a terribly parochial definition that clearly suffers from a narrow perspective—surely, many receptors, and likely many non-receptor effects, can create what is already commonly understood as a  effect.

A timely attempt to bring further order to the world of psychedelic molecules was recently put forward in the journal Current Biology. The authors offer a divide-and-conquer approach that assigns psychedelics to one of three classes based on their : tryptamines, ergolines and phenethylamines. The tryptamines, to which 5Ht (serotonin) belongs, yield familiar molecules including psilocybin, psilocin, DMT and 5-MeO-DMT via the addition of methyl groups to the ethylamine chain, as well as the addition of other critical side groups, to the core fused indole benzene-pyrrole ring system.

Psychedelics
Credit: B. Kelmendi et. al. 2022

The ergolines were initially isolated from the ergot fungus, and can be further processed into more familiar derivatives like LSD. Finally, the phenethylamines are based on a scaffold of a benzene ring with an amino group attached through two-carbon. This group includes 2C-B, mescaline, amphetamine analogs such as DOI and DOM, and derivatives such as 25I-NBOMe. This division is handy, hardly exhaustive. some phenethylamines such as MDMA, act through entirely different mechanisms, while deliriants such as muscimol and scopolamine, and dissociatives such as salvinorin A, ibogaine, , phencyclidine (PCP), and ketamine have entirely unique structures.

All this, and much more was actually laid out many years ago by the late "godfather of psychedelics," Alexander Shulgin, who, together with his wife, penned two famous books on the topic based on his direct experiences with hundreds of compounds he invented and synthesized. These two still unmatched treatises, PiHKAL and TiHKAL (standing for "Phenethylamines I Have Known And Loved" and "Tryptamines I Have Known And Loved"), methodically lay out the first exhaustive rational drug design approach to designer psychedelics. Each instruction synthesis account is typically accompanied by thorough dosing recommendations, comparative routes of administration, bioassays, method of metabolism, and detailed commentary on the time course of effects.

So what has science been able to offer since Shulgin? There have been at least two contributions to the field: The first is the structural determination of a psychedelic-bound 5-HT2A receptors at near-atomic resolution. These reconstructions have enabled detailed computer simulations to identify thousands of candidate compounds which can be tested to evaluate their kinetic binding properties. The second has been major advances in tracing the  that are activated by receptor binding. In this case, the established canonical pathway involves the G-protein Gαq, which dissociates from the receptor and from its Gβγ partners and activates other downstream effector proteins upon receptor activation.

But there is also another parallel, G-protein-independent pathway mediated by β-arrestins that has come to be viewed with increasing relevance for these drugs. "Some psychedelics appear to be biased ligands such that they preferentially engage 5-HT2A receptors in conformations that favor β-arrestin signaling over the G-protein pathway. In contrast to 5-HT2A receptors, the 5-HT1A receptors are Gi/o-protein coupled and activate other signaling proteins." These kinds of observations now form the basis of more recent and sometimes dubious efforts to deconvolve desirable antidepressant effects of receptor activation from any of the undesirable hallucinogenic effects.

For example,  comparing receptor-bound serotonin with similarly non-hallucinogenic ligands like lisuride reveal a bias toward arrestin recruitment. Based on these analyses, researchers were able to design arrestin-biased ligands that displayed antidepressant-like activity in mice without hallucination effects. They note that arrestin recruitment alone is insufficient for antidepressant effects, but the low G-protein signaling of the arrestin-biased ligands appears to allow antidepressant effects without causing hallucination.

Sleep deprivation increases serotonin 2a receptor response in brain
More information: Benjamin Kelmendi et al, Psychedelics, Current Biology (2022). DOI: 10.1016/j.cub.2021.12.009
Dongmei Cao et al, Structure-based discovery of nonhallucinogenic psychedelic analogs, Science (2022). DOI: 10.1126/science.abl8615Journal information: Current Biology , Science 
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