Showing posts sorted by relevance for query SPAGYRIC HOMEOPATHY. Sort by date Show all posts
Showing posts sorted by relevance for query SPAGYRIC HOMEOPATHY. Sort by date Show all posts

Friday, April 10, 2020

ALCHEMY NOT QUACKERY

Does homeopathy work? 

Practitioners and patients on benefits of the alternative therapy and when you should consider it

Homeopathy, an alternative medical practice developed in the late 1700s, uses very dilute amounts of natural substances to treat ailments

Patients use it to treat problems such as irritable bowel syndrome, skin issues, allergies and nausea



Kate Whitehead Published:9 Apr, 2020


Homeopathy is a natural form of medicine that has been around since the late 1700s, and is recommended as an alternative therapy by some doctors to their patients. Photo: AFP via Getty Images

When Elkey Liu’s daughter was a toddler she suffered from a nasal allergy. She sneezed, had a runny nose and, when it was severe, her eyes became swollen. The allergens triggered eczema, so the doctor prescribed antihistamines as well as hydrocortisone cream for her body.

“I didn’t want my daughter to have too much Western medicine in her body because she was so little. I’d read about homeopathy and friends recommended a homeopath, Dr Sonal, so I took her,” says Liu.

Sonal Hattangdi-Haridas, who practices at the Maya Health Institute in Hong Kong’s Central business district, gave homeopathic drops to reduce the child’s response to the allergens and also recommended cutting down on dairy and gluten. Within three months her issues had cleared up – so when Liu’s son was born and had eczema, she took the homeopathic route again.

“I think homeopathy is good for kids and babies. It’s not good for them to have too much strong, Western medicine,” says Liu.

Sonal Hattangdi-Haridas practises at the Maya Health Institute in Central.

THE LEGACY OF PARACELSUS AKA DR. BOMBASTUS 

Homeopathy is an alternative medical practice that was developed in the late 1700s in Germany in which extremely dilute amounts of certain natural substances are used to treat various ailments. It is based on rigorous dilutions and mixing, called successions.

Homeopathic medicine is based on the belief that ‘like cures like’,” says Sonal, who has a doctorate in Homeopathy from The British Institute of Homeopathy in London as well as a master’s in nutritional medicine.

In other words, something that brings on symptoms in a healthy person can – in a very small dose – treat an illness with similar symptoms. This is meant to trigger the body’s natural defences.


“It’s an energetic medicine – the original molecules [of the remedy] exist, in a minute dose, and go through a series of dilutions in double-distilled water,” says homeopathic doctor Manisha Khiani, who is registered under India’s Maharashtra Council of Homeopathy and practises at a clinic in Central. “It’s the energy of the water which carries the expression of the medicine.”

(TODAY IT IS ALSO KNOWN AS SPAGYRIC CHEMISTRY, GOOGLE FRATER ALBERTUS )

Sonal’s youngest client was just three weeks old (treated for a rash) and her oldest patients are in their late 80s. She has found homeopathy to be especially effective for treating functional diseases, such as irritable bowel syndrome, skin issues and allergies, as well as
anxiety.

Manisha Khiani is registered under Maharashtra Council 
of Homeopathy and practices at a clinic in Central

Sonal recommends that patients seek advice as soon as something feels amiss, rather than waiting for it to become “a raging fire”.

Conventional medicine has its place, but it works on the basis of diagnosis; if there is no diagnosis it can’t do anything for you. But if something is bothering you – say, silent reflux or fluid in the middle ear which is making you feel dizzy but not bad – then homeopathy can help,” she says, adding that she has found it effective for women with pre-menopausal symptoms.

A consultation with a homeopath usually takes longer than with a doctor. They will usually ask you about any specific health conditions and also about your general well-being, emotional state, lifestyle and diet. Sonal says the first session with a client generally takes about 40 minutes; each appointment after that is usually no more than 20 to 25 minutes.

“I like to get a lot of background information. I want to build up a holistic picture,” she says.

I see more people coming to complementary systems of medicine here and more people wanting to try homeopathy Dr Manisha Khiani

Aromatherapist Emma Ross consulted her doctor just over a year ago for support with digestive issues – food intolerances and gut distress that gave her abdominal pain and almost constant nausea. Knowing that she was open to alternative therapies, her doctor recommended her to a homeopath.

“At the outset I was going once a week, and each time I went I got a different prescription of drops and [they] had me on a limited diet. It helped a lot with the nausea and the anxiety which I was feeling. I went from a place of being unwell to feeling normal,” says Ross.


Emma Ross consulted her GP just over a year ago, who recommended her to a homeopath. Photo: Edward Wong

Khiani’s response to those who see homeopathy as a pseudoscience is straightforward: “I say try it and see the results for yourself. The fact that it has been around for 200 years and is going strong speaks for itself.”

The World Health Organisation has acknowledged the role of homeopathy in health care. Last year, it issued a report on traditional and complementary medicine that highlighted the widespread use of homeopathy around the world and the increasing number of insurances policies that cover this alternative medicine.


How a naturopath made herself well, and how she helps others
10 Sep 2018


In Hong Kong, it is possible for a homeopath to practice even if they have no qualifications or experience, so choose your homeopath wisely. Sonal recommends choosing one who is medically aware.

“Homeopathic training is very different in different countries. In certain situations you can do an online course. There are three countries in the world where you need medical training to become a homeopath: India, France and Germany,” she says.

Although homeopathy is still fairly niche in Hong Kong, Khiani sees that slowly changing.

“I see more people coming to complementary systems of medicine here and more people wanting to try homeopathy. It’s about creating a greater awareness,” she says.

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Saturday, December 30, 2023

 SPAGYRIC  HOMEOPATHY

Angelica gigas extract inhibits acetylation of eNOS in vascular dysfunction


Peer-Reviewed Publication

IMPACT JOURNALS LLC

Figure 6 

IMAGE: 

FIGURE 6. AGE IMPROVES ENDOTHELIAL CELL FUNCTIONS IN OXLDL-TREATED HUVECS.

view more 

CREDIT: 2023 LEE ET AL.


“Angelica gigas Nakai (AG), a traditional medicinal herb, is garnering scientific attention for its potential in addressing a variety of health conditions.”

BUFFALO, NY- December 27, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 23, entitled, “Angelica gigas extract inhibits acetylation of eNOS via IRE1α sulfonation/RIDD-SIRT1-mediated posttranslational modification in vascular dysfunction.”

Angelica gigas NAKAI (AG) is a popular traditional medicinal herb widely used to treat dyslipidemia owing to its antioxidant activity.

https://en.wikipedia.org/wiki/Angelica_gigas

Angelica gigas ... Angelica gigas, also called Korean angelica, giant angelica, purple parsnip, and dangquai, is a monocarpic biennial or short lived perennial ...


Vascular disease is intimately linked to obesity-induced metabolic syndrome, and AG extract (AGE) shows beneficial effects on obesity-associated vascular dysfunction. However, the effectiveness of AGE against obesity and its underlying mechanisms have not yet been extensively investigated. In this new study, researchers Geum-Hwa Lee, Hwa-Young Lee, Young-Je Lim, Ji-Hyun Kim, Su-Jin Jung, Eun-Soo Jung, Soo-Wan Chae, Juwon Lee, Junghyun Lim, Mohammad Mamun Ur Rashid, Kyung Hyun Min, and Han-Jung Chae from Jeonbuk National University and Jeonbuk National University Hospital supplemented 40 high fat diet (HFD) rats with 100–300 mg/kg/day of AGE to determine its efficacy in regulating vascular dysfunction. 

“[...] the primary aim of this study is to examine the inhibitory effects of AGE on dyslipidemia-associated vascular dysfunction, with a focus on its potential mechanisms of action.”

The vascular relaxation responses to acetylcholine were impaired in HFD rats, while the administration of AGE restored the diminished relaxation pattern. Endothelial dysfunction, including increased plaque area, accumulated reactive oxygen species, and decreased nitric oxide (NO) and endothelial nitric oxide synthase (eNOS) Ser1177 phosphorylation, were observed in HFD rats, whereas AGE reversed endothelial dysfunction and its associated biochemical signaling. Furthermore, AGE regulated endoplasmic reticulum (ER) stress and IRE1α sulfonation and its subsequent sirt1 RNA decay through controlling regulated IRE1α-dependent decay (RIDD) signaling, ultimately promoting NO bioavailability via the SIRT1-eNOS axis in aorta and endothelial cells.

Independently, AGE enhanced AMPK phosphorylation, additionally stimulating SIRT1 and eNOS deacetylation and its associated NO bioavailability. Decursin, a prominent constituent of AGE, exhibited a similar effect in alleviating endothelial dysfunctions. These data suggest that AGE regulates dyslipidemia-associated vascular dysfunction by controlling ROS-associated ER stress responses, especially IRE1α-RIDD/sirt1 decay and the AMPK-SIRT1 axis.

“Ultimately, this study presents clearly evidence that AGE is a promising natural product-based functional food/herbal medicine candidate for preventing or regulating hyperlipidemic cardiovascular complications.”

 

Read the full paper: DOI: https://doi.org/10.18632/aging.205343 

Corresponding Authors: Kyung Hyun Min, Han-Jung Chae

Corresponding Emails: khmin1492@jbnu.ac.krhjchae@jbnu.ac.kr 

Keywords: Angelica gigas, decursin, IRE1α, sulfonation, RIDD, SIRT1, vascular dysfunction

Sign up for free Altmetric alerts about this article: https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.https://doi.org/10.18632/aging.205343

 

About Aging:

Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at www.Aging-US.com​​ and connect with us:

 

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For media inquiries, please contact media@impactjournals.com.

 

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Friday, July 28, 2023

POSTMODERN SPAGYRIC HOMEOPATHY

Study highlights importance of quality and potency of saw palmetto extracts in prostate health supplements


7 out of 28 popular products studied contain the amount of authentic saw palmetto extract shown to be clinically effective in relieving lower urinary tract symptoms affecting millions of men


Peer-Reviewed Publication

VALENSA INTERNATIONAL




A new study published in the Journal of Urology Open Plus reveals that 7 saw palmetto products met the identity and potency standards to effectively address urinary tract symptoms associated with an enlarged prostate. According to the lead author of the study, Dr. Bilal Chughtai, who is a board-certified urologist, of the 28 supplements included in the study, only six of the lipid extracts and one multi-active product were found to have the appropriate dosage of 320 milligrams of saw palmetto extract and the minimum 80% fatty acids clinically shown to address inflammation and improve symptoms that nearly all men will experience in their lifetime, like increased urination, sudden urgency, weak stream and disrupted sleep. 

The study included some of the popular saw palmetto retail products, which consumers find in stores and online platforms like Amazon, including berry powders, extracts, blends and multi-actives. The blinded study was performed at Eurofins Food Chemistry Testing, Inc., Madison, WI. Total fatty acid content ranged from 0.796% for a berry powder product to 89.923% for a lipid extract product. None of the berry powders met the criteria for clinical efficacy. Lab tests confirmed that Valensa USPlus® was unique in meeting the criteria established in the US Pharmacopeia monograph for standardized saw palmetto extracts (min. 80% total fatty acids), met the lipid profile for an authentic product, and was found to contain the clinically effective dose of 320 mg.

“Only concentrated extract of mature saw palmetto berries has been found to inhibit the biological process by which testosterone gets converted to DHT, which leads to benign prostate enlargement,” said Dr. Bilal Chughtai. “This study not only confirms the rampant variability of saw palmetto products, but also highlights the need for physicians and industry to verify the quality of the supplements they’re recommending to patients and consumers to ensure the best results possible.”

Saw palmetto is a wildcraft plant native to remote areas of the southeastern U.S. Among increased demand of saw palmetto, there has been widespread misrepresentation, blending and dilution of saw palmetto extracts with less expensive plant oils like coconut, canola, olive and sunflower or use unripened berries that do not provide clinical benefit. 

Valensa’s USPlus® is the first and only USP verified ingredient that is a lipidosterolic extract of  saw palmetto berry, also known as Serenoa repens. As per the newly-published study, only one of the 28 products met United States Pharmacopeia criteria for a standardized lipidosterolic extract, defined as total fatty acid content ≥80% and a fatty acid profile indicative of authentic Serenoa repens based on the ratios of the lauric acid concentration to 9 other individual fatty acid concentrations.

Valensa’s USPlus® rigorous quality-control process ensures the product contains only mature, wild-harvested, Fresh from Florida® saw palmetto berries that are sourced using sustainable harvesting practices. Valensa USPlus is able to provide this uncompromising quality through a proprietary ultrahigh pressure extraction process that delivers a standardized lipidosterolic extract of saw palmetto for clinical effectiveness. 

“Without studies like this to bring quality issues to light, it’s very difficult for consumers to know if they’re taking a supplement full of ‘sawdust’ that doesn’t do anything or a quality saw palmetto product that promotes your prostate health,” said Stephen Hill, Vice President of Quality and Regulatory of Valensa International. “By understanding the role that high-quality saw palmetto extract can play in men’s health, millions of men can benefit from this safe and natural solution to maintaining prostate health and possibly prevent or delay the need for more serious medical interventions down the line.”

Benign prostatic hyperplasia, or an enlarged prostate, affects about 50 percent of men between the ages of 51 and 60 and up to 90 percent of men older than 80. Valensa USPlus is the first and only USP Verified saw palmetto extract ingredient available to men to support lower urinary tract symptoms with no sexual side effects.*^ 

USP, the United States Pharmacopeia, is a 200 year old non-profit scientific organization that sets standards for drugs and dietary supplements. USP helps protect patient safety and improve the health of people around the world.

Learn more about Valensa USPlus’s harvest to bottle quality control standards and patented extraction process here: https://www.youtube.com/watch?v=JGddboRQdjk 

*Adapted from: Carraro JC, et al. Prostate. 1996;29:231-240; Debruyne F, et al. Eur Urol. 2002;41:497-506; Latil A, et al. Prostate. 2015;75:1857-1867; Pytel YA, et al. Adv Ther. 2002;19:297-306; Zlotta AR, et al. Eur Urol. 2005;48:269-276

^These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

About Valensa International USPlus®
Located in Eustis, FL, Valensa International USPlus is the first and only USP Verified saw palmetto oil extract in the world. Learn more at www.Valensa.com/USPlus/.

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Friday, July 14, 2023

 21ST CENTURY SPAGYRIC HOMEOPATHY

New study using human fibroid cells supports use of green tea compound as treatment for uterine fibroids


Fibroids are the most common benign uterine tumors and about 25% of patients experience significant symptoms, driving the need for preventative measures


Peer-Reviewed Publication

JOHNS HOPKINS MEDICINE




In a pre-clinical, proof-of-concept study from Johns Hopkins Medicine, researchers found that epigallocatechin gallate (EGCG), a green tea compound with powerful antioxidant properties, could be promising for both treating and preventing uterine fibroids. Results of the study, first posted online May 25 in Scientific Reports, add to growing evidence that EGCG may reduce fibroid cell growth. The study was specifically designed to identify the biochemical mechanisms responsible for EGCG action in fibroid cells.

The investigators emphasize that their study involves human fibroid cells grown in the laboratory and treated with EGCG extract to explore the possibility of oral EGCG supplementation as a therapy, rather than just drinking cups of green tea as a preventative measure for uterine fibroids.

“The purpose of this study was to examine how EGCG works to treat and prevent uterine fibroids,” says James Segars Jr., M.D., professor of gynecology and obstetrics at the Johns Hopkins University School of Medicine. “There is no standard protocol for uterine fibroid disease management or prevention, no tools to prevent their growth, so finding a safe nonsurgical therapy is important.”

Uterine fibroids are the most common benign tumors of the uterus. Made up of smooth muscle cells and a large matrix of connective tissue, the fibroids range in size from nearly microscopic to bulky masses that can enlarge and distort the uterus.

An estimated 77% of women will develop fibroids in their lifetime, most of them by age 50. Black and Hispanic women develop them at 1.5 to two times the rate of white women. 

While many people with uterine fibroids are without symptoms, about 25% experience significant symptoms including heavy uterine bleeding, pelvic pain and infertility. Uterine fibroids are the leading cause of hospitalizationhysterectomy in the United States, according to the U.S. Department of Health and Human Services. In addition to complete removal of the uterus, surgical treatment may include various means of removing fibroid tumors from the uterine wall.

For the new study, researchers used laboratory cultures of uterine fibroids collected from living patients. Because uterine fibroid cells have a large extracellular matrix (the network of macromolecules and minerals in tissues that support, but are not part of, cells) compared to normal cells, researchers designed their experiments to see if treatment of cells with EGCG affects protein expression associated with this matrix. Specifically, they studied fibronectin, a matrix protein; cyclin D1, a protein involved with cell division; and connective tissue growth factor (CTGF) protein.

Cells were dosed with 100 micromoles (a micromole is 1 millionth of a mole) per liter of EGCG in growth media for 24 hours, and then a Western blot — a laboratory technique used to detect a specific protein in a blood or tissue sample — was performed. In this study, researchers looked for levels of cyclin D1 and CTGF proteins in EGCG-treated fibroid cells compared to untreated cell.

They found that EGCG reduced protein levels of fibronectin by 46% to 52%, compared with an untreated control group of fibroid cells. They also found that EGCG disrupted pathways involved in fibroid tumor cell growth, movement, signaling and metabolism, and they saw up to an 86% decrease in CTGF proteins compared with the control group.

“The results from this study show that EGCG targets many signaling pathways involved in fibroid growth, particularly the extracellular matrix,” says study lead author Md Soriful Islam, Ph.D., M.Sc., a postdoctoral fellow at the Johns Hopkins University School of Medicine. “EGCG supplements could be an easily accessible and natural way to relieve symptoms and slow fibroid growth.”

These results lend support to the FRIEND (Fibroids and Unexplained Infertility Treatment With Epigallocatechin Gallate; A Natural Compound in Green Tea) study (ClinicalTrials.gov identifier NCT05364008), an ongoing clinical trial of EGCG in women with fibroids who are seeking pregnancy. While results from this study show promise, researchers caution that more studies need to be done, and consumers should not try to self-dose with green tea supplements. Future research on EGCG will include clinical trials with large and diverse patient groups to determine optimal doses as well as possible side effects of EGCG supplementation.

Other scientists at the Johns Hopkins University School of Medicine who contributed to this research are Maclaine Parish, Joshua Brennan and Briana Winer. 

Segars has been a primary investigator on research sponsored by Bayer, Abbvie, BioSpecifics Technologies Corp., Allergan and Myovant Sciences. All other authors have no conflicts to disclose.  

This research was partly supported by the National Institutes of Health’s Eunice Kennedy Shriver National Institute of Child Health and Human Development, and the Howard W. and Georgeanna Seegar Jones Endowment.

Disclaimer: AAAS and Eure

Thursday, July 06, 2023

POSTMODERN SPAGYRIC HOMEOPATHY

Scientists make common pain killers from pine trees instead of crude oil


Common drugs such as paracetamol and ibuprofen can be made from a chemical from pine trees instead of crude oil products.

Peer-Reviewed Publication

UNIVERSITY OF BATH

Conversion of β-pinene into paracetamol and ibuprofen 

IMAGE: CONVERSION OF Β-PINENE INTO PARACETAMOL AND IBUPROFEN view more 

CREDIT: UNIVERSITY OF BATH




Common drugs such as paracetamol and ibuprofen can be made from a chemical from pine trees instead of crude oil products.

  • Turpentine is a waste product from the paper industry and is usually burned to generate energy.
  • Around 350,000 tonnes of turpentine is generated in the world – enough to supply the global demand for paracetamol and ibuprofen (~100,000 tonnes).
  • New method converts one of the components of turpentine (β-pinene) into a range of valuable chemical starting blocks for perfumes, plastics and pharmaceuticals including paracetamol and ibuprofen.
  • Turpentine is a biorenewable, sustainable starting material that could replace crude oil products, and is not subject to price fluctuations of crude oil.

A team of scientists, from the University of Bath’s Department of Chemistry and Institute for Sustainability have found a way to create two of the world’s most common painkillers, paracetamol and ibuprofen, out of a compound found in pine trees, which is also a waste product from the paper industry.

It is perhaps not widely known that many common pharmaceuticals are manufactured using chemical precursors derived from crude oil, presenting a niche sustainability challenge as the world targets Net Zero.

The research team from Bath has developed a method of creating a range of pharmaceutical  precursors from biorenewable β-pinene, a component of turpentine which is a waste by-product from the paper industry (annual production >350,000 tonnes).

They successfully converted β-pinene into two everyday painkillers, paracetamol and ibuprofen, which are produced on ~100,000 tonne scales annually.

They also successfully synthesised a range of other precursor chemicals from turpentine, including 4-HAP (4-hydroxyacetophenone), which is the precursor of drugs including beta-blockers and the asthma inhaler drug, salbutamol, as well as others widely used for perfumes and in cleaning products.

They hope that this more sustainable “biorefinery” approach could replace the need for crude oil products in the chemical industry.

Dr Josh Tibbetts, Research Associate in the University’s Department of Chemistry, said: “Using oil to make pharmaceuticals is unsustainable – not only is it contributing to rising CO2 emissions, but the price fluctuates dramatically as we are greatly dependent on the geopolitical stability of countries with large oil-reserves, and it is only going to get more expensive.

“Instead of extracting more oil from the ground, we want to replace this in the future with a ‘bio-refinery’ model.

“Our turpentine-based biorefinery model uses waste chemical by-products from the paper industry to produce a spectrum of valuable, sustainable chemicals that can be used in a wide range of applications from perfumes to paracetamol.”

Instead of putting chemicals in a large reactor to create separate batches of product, the method uses continuous flow reactors, meaning production can be uninterrupted and easier to scale up.

Whilst the process in its current form may be more expensive than using oil-based feedstocks, consumers may be prepared to pay a slightly higher price for more sustainable pharmaceuticals that are completely plant-derived.

The research, funded by the Engineering and Physical Sciences Research Council, is published in the journal ChemSusChemhttps://doi.org/10.1002/cssc.202300670

Biorenewable paracetamol produced by the team.

CREDIT

University of Bath

Flow reactor used in the synthesis of paracetamol where starting materials are flowed through in a continuous process to give a constant stream of products.

CREDIT

University of Bath

Tuesday, August 01, 2023

SPAGYRIC HOMEOPATHY 

New research shows potential role for mangos in supporting vascular health and antioxidant activities


Posters presented at Nutrition 2023 advance the role of mangos in improving public health


Reports and Proceedings

WILD HIVE




Boston - July 27, 2023 - Mangos are one of the most popular fruits1 in the world, grown in more than 100 countries2 globally and consumed by an extremely diverse population. Now, two new studies funded by the National Mango Board and presented as posters during the American Society for Nutrition’s Annual Conference (Nutrition 2023) show mangos may play a role in risk reductions for vascular issues while helping to improve antioxidant levels among relatively healthy adult men and women who are overweight or obese.

“Mangos contribute a variety of nutrients, phytochemicals and bioactive compounds to the diet—including 50 percent of the daily value (DV) for vitamin C, 15 percent of the DV for folate and 15 percent of the DV for copper, and mangoes are also a predominant source of the bioactive compound mangiferin,” says Mee Young Hong, Ph.D., the primary investigator for both studies and professor at the School of Exercise and Nutritional Sciences in the College of Health and Human Services at San Diego State University. “It’s likely the unique matrix of vitamins and bioactive compounds synergistically working together that resulted in our findings,” says Young Hong.

Both crossover interventions followed the same 27 overweight or obese participants (16 males, 11 females; BMI 31.8 +/- 4.1 kg/m2) that were between the ages of 18-55 for 28 weeks. The participants were separated into two groups and instructed to eat either a 100-calorie snack of mangos (1 cup) or a 100-calorie snack of low-fat cookies for 12 weeks, as part of their normal lifestyle and eating patterns. Following the first 12 weeks, participants took a 4-week washout break then switched groups and consumed the alternate snack for another 12 weeks. During each 12-week period, participants provided fasting blood samples three times: at baseline, week 4 and week 12.

When the mango snack was eaten versus the low-fat cookie snack, following the12-week intervention, findings from the first study show significant health-positive changes to two markers of oxidative stress, reduced vascular cell adhesion molecule-1 (VCAM-1) and increased superoxide dismutase (SOD). Findings from the second study show a significant increase of glutathione peroxidase (GPX), a powerful antioxidant enzyme. Other biomarker and biochemical analyses performed across the two studies, which tested additional vascular, inflammatory, and immune risk factors and mediators, did not yield significant results.

“SOD and VCAM-1 play opposite roles as risk factors for vascular issues,” says Young Hong. “While the SOD enzyme reduces risk by breaking down charged oxygen molecules called superoxide radicals,3 which are toxic, the VCAM-1 gene causes cells to stick together along the vascular lining, leading to increased risk for issues.4 To achieve good vascular health, we want to see these two compounds move in opposite directions—SOD up and VCAM-1 down—which is what happened in the study. Additionally, GPX acts by converting hydrogen peroxide to water in the body, thus reducing the harmful oxidative effects of hydrogen peroxide,”5 says Young Hong.

“The totality of findings across both studies continues to add to a growing body of fresh mango research and can help to further advance the scientific understanding of the role mangos can play in helping all Americans achieve their health and wellness goals,” says Leonardo Ortega, Director of Research, National Mango Board.

“Vascular diseases include strokes, which are the third leading cause of death in the United States. Helping Americans find food-first solutions for reducing risks, like including more fruits, such as mangos, in the diet, is critical to reverse these trends and improve public health,” says Young Hong.

With only 70 calories and over 20 different vitamins and minerals, a 3/4-cup serving of mango is nutrient-dense, making it a superfood. Because mangos are widely consumed in cultures around the world including the United States, research into their health benefits contributes to a better understanding of their place in a healthy diet.

For more information, please visit www.mango.orgClick here for mango photography.

 

  1. National Mango Board (2023) Mango Facts. Available at: https://www.mango.org/mango-facts/  
  2. Mitra, S.K. (2016). Mango production in the world – present situation and future prospect. Acta Hortic. 1111, 287-296 DOI: 10.17660/ActaHortic.2016.1111.41 https://doi.org/10.17660/ActaHortic.2016.1111.41
  3. MedlinePlus, Bethesda (MD): National Library of Medicine (US); [updated 2020 Jun 24]. SOD1 gene. Available at: https://medlineplus.gov/genetics/condition/noonan-syndrome/.
  4. National Library of Medicine (2023) VCAM1 vascular cell adhesion molecule 1 [Homo sapiens (human)]. Available at: https://www.ncbi.nlm.nih.gov/gene/7412#bibliography
  5. Lubos E, Loscalzo J, Handy DE. Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal. 2011 Oct 1;15(7):1957-97. doi: 10.1089/ars.2010.3586. Epub 2011 Apr 10. PMID: 21087145; PMCID: PMC3159114.

 

Drinking kombucha may reduce blood sugar levels in people with type-two diabetes


Small pilot study suggests larger trials warranted to confirm potential benefit of fermented tea


Peer-Reviewed Publication

GEORGETOWN UNIVERSITY MEDICAL CENTER



WASHINGTON — People with type-II diabetes who drank the fermented tea drink kombucha for four weeks had lower fasting blood glucose levels compared to when they consumed a similar-tasting placebo beverage, according to results from a clinical trial conducted by researchers at Georgetown University's School of Health, the University of Nebraska-Lincoln and MedStar Health. This finding, from a pilot 12-person feasibility trial, points to the potential for a dietary intervention that could help lower blood sugar levels in people with diabetes and also establishes the basis for a larger trial to confirm and expand upon these results.

This finding was reported in Frontiers in Nutrition on August 1, 2023.

Kombucha is a tea fermented with bacteria and yeasts and was consumed as early as 200 B.C. in China, but it did not become popular in the U.S. until the 1990s. Its popularity has been bolstered by anecdotal claims of improved immunity and energy and reductions in food cravings and inflammation, but proof of these benefits has been limited.

“Some laboratory and rodent studies of kombucha have shown promise and one small study in people without diabetes showed kombucha lowered blood sugar, but to our knowledge this is the first clinical trial examining effects of kombucha in people with diabetes,” says study author Dan Merenstein, M.D., professor of Human Sciences in Georgetown’s School of Health and professor of family medicine at Georgetown University School of Medicine. “A lot more research needs to be done but this is very promising.”

Merenstein continued, “A strength of our trial was that we didn't tell people what to eat because we used a crossover design that limited the effects of any variability in a person’s diet.”

The crossover design had one group of people drinking about eight ounces of kombucha or placebo beverage daily for four weeks and then after a two-month period to ‘wash out’ the biological effects of the beverages, the kombucha and placebo were swapped between groups with another four weeks of drinking the beverages. Neither group was told which drink they were receiving at the time.

Kombucha appeared to lower average fasting blood glucose levels after four weeks from 164 to 116 milligrams per deciliter while the difference after four weeks with the placebo was not statistically significant. Guidelines from the American Diabetes Association recommended blood sugar levels before meals should be between 70 to 130 milligrams per deciliter.

The researchers also looked at the makeup of fermenting micro-organisms in kombucha to determine which ingredients might be the most active. They found that the beverage was mainly comprised of lactic acid bacteria, acetic acid bacteria, and a form of yeast called Dekkera, with each microbe present in about equal measure; the finding was confirmed with RNA gene sequencing.

The kombucha used in this study was produced by Craft Kombucha, a commercial manufacturer in the Washington, DC, area. It has been re-branded as Brindle Boxer Kombucha.

“Different studies of different brands of kombucha by different manufacturers reveal slightly different microbial mixtures and abundances,” says Robert Hutkins, Ph.D., University of Nebraska-Lincoln and the study’s senior author. “However, the major bacteria and yeasts are highly reproducible and likely to be functionally similar between brands and batches, which was reassuring for our trial.”

“An estimated 96 million Americans have pre-diabetes -- and diabetes itself is the eighth leading cause of death in the U.S. as well as being a major risk factor for heart disease, stroke and kidney failure,” says Chagai Mendelson, M.D., lead author who was working in Merenstein’s lab at Georgetown while completing his residency at MedStar Health. “We were able to provide preliminary evidence that a common drink could have an effect on diabetes. We hope that a much larger trial, using the lessons we learned in this trial, could be undertaken to give a more definitive answer to the effectiveness of kombucha in reducing blood glucose levels, and hence prevent or help treat type-II diabetes.”

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Additional study authors at Georgetown University are Sabrina Sparkes, a student in the School of Health, Varun Sharma and Sameer Desale. In addition to Hutkins, Chloe Christensen, Jennifer M. Auchtung, Car Reen Kok and Heather E. Hallen-Adams are at the University of Nebraska-Lincoln.

The authors wish to express their gratitude to Tanya Maynigo, founder of Craft Kombucha for providing the kombucha and placebo kombucha for this study. She teaches kombucha classes in Washington, DC, and this year is launching a new brand of her favorite drink called Brindle Boxer Kombucha.

The study received no external funding.

Hutkins is a co-founder of Synbiotic Health. Auchtung has a financial interest in Synbiotic Health. Merenstein is president of the International Scientific Association for Probiotics and Prebiotics board, a non-paid position. All other authors have no competing interests to declare. All kombucha and placebo drinks were donated by Craft Kombucha. Craft Kombucha did not have any access to data reported in this study. No author has any financial ties with Craft Kombucha.

About Georgetown University Medical Center
As a top academic health and science center, Georgetown University Medical Center  provides, in a synergistic fashion, excellence in education — training physicians, nurses, health administrators and other health professionals, as well as biomedical scientists — and cutting-edge interdisciplinary research collaboration, enhancing our basic science and translational biomedical research capacity in order to improve human health. Patient care, clinical research and education is conducted with our academic health system partner, MedStar Health. GUMC’s mission is carried out with a strong emphasis on social justice and a dedication to the Catholic, Jesuit principle of cura personalis -- or “care of the whole person.” GUMC comprises the School of Medicine, the School of Nursing, School of Health, Biomedical Graduate Education, and Georgetown Lombardi Comprehensive Cancer Center. Designated by the Carnegie Foundation as a doctoral university with "very high research activity,” Georgetown is home to a Clinical and Translational Science Award from the National Institutes of Health, and a Comprehensive Cancer Center designation from the National Cancer Institute. Connect with GUMC on Facebook (Facebook.com/GUMCUpdate) and on Twitter (@gumedcenter).