Friday, June 09, 2023

The first prehistoric wind instruments discovered in the Levant

Peer-Reviewed Publication

CNRS

The first prehistoric wind instruments discovered in the Levant 

IMAGE: THE SEVEN AEROPHONES DISCOVERED AT EYNAN-MALLAHA view more 

CREDIT: © LAURENT DAVIN


Although the prehistoric site of Eynan-Mallaha in northern Israel has been thoroughly examined since 1955, it still holds some surprises for scientists. Seven prehistoric wind instruments known as flutes, recently identified by a Franco-Israeli team1, are the subject of an article published on 9 June in Nature Scientific Reports. The discovery of these 12,000 -year-old aerophones is extremely rare – in fact, they are the first to be discovered in the Near East. The “flutes”, made from the bones of a small waterfowl, produce a sound similar to certain birds of prey (Eurasian sparrowhawk and common kestrel) when air is blown into them. The choice of bones used to make these instruments was no accident – larger birds, with bigger bones that produce deeper sounds, have also been found at the site. The Natufians, the Near Eastern civilisation that occupied this village between 13,000 and 9,700 BC, deliberately selected smaller bones in order to obtain the high-pitched sound needed to imitate these particular raptors. The instruments may have been used for hunting, music or to communicate with the birds themselves. Indeed, it is clear that the Natufians attributed birds with a special symbolic value, as attested by the many ornaments made of talons found at Eynan-Mallaha. The village, located on the shores of Lake Hula, was home to this civilisation throughout its 3,000 years of existence. It is therefore of vital importance in revealing the practices and habits of a culture at the crossroads between mobile and sedentary lifestyles, and the transition from a predatory economy to agriculture. This work2 was supported by the Fyssen Fondation and the ministère des Affaires étrangères.

 

Notes


  1. The team is co-directed by Laurent Davin (post-doctoral researcher at the Fyssen Fondation) and José-Miguel Tejero (University of Vienna, University of Barcelona) and includes scientists from the Centre de recherche français à Jérusalem (CNRS/Aix-Marseille Université/ministère de la Culture), the laboratoire Technologie et ethnologie des mondes préhistoriques (CNRS/Université Panthéon-Sorbonne/Université Paris Nanterre), The Hebrew University of Jerusalem (Institute of Archaeology), Israel Antiquities Authority, Virginia Commonwealth University (Department of Forensic Science), École Nationale Vétérinaire (Laboratoire d’Anatomie comparée, Nantes), the laboratoire Archéologies et sciences de l’Antiquité (CNRS/ministère de la Culture/Université Panthéon-Sorbonne/Université Paris Nanterre) and the l’Institut d’ethnologie méditerranéenne, européenne et comparative (CNRS/Université Aix-Marseille).
  2. Excavation of the Eynan-Mallaha site is still ongoing, under the direction of CNRS researcher Fanny Bocquentin and Israel Antiquities Authority researcher Lior Weisbrod.

Children in Chile saw 73% fewer TV ads for unhealthy foods and drinks following trailblazing marketing restrictions

Peer-Reviewed Publication

UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL



Chilean policies aimed at reining in unhealthy food marketing are succeeding in protecting children from the onslaught of television advertisements (TV ads) for these products, according to new research. The country’s multi-phased regulations, which began in 2016, have led to a 73% drop in children’s exposure to TV ads for regulated foods and drinks (those that exceed legal thresholds for calories, sugar, salt or saturated fat) by 2019. During this time, the number of ads for unhealthy foods dropped 64% on all TV programs and 77% during children’s programming. Researchers also found that 67% fewer unhealthy food ads used child-directed creative content such as cartoons, characters, toys or contests, which are also prohibited under the country’s laws.

These and other findings from researchers at the University of Chile, Diego Portales University and the University of North Carolina at Chapel Hill underscore both the potential and need for strict rules around marketing to build healthier eating habits. The study also highlights the importance of a key policy addition contributing to the regulations’ success: The initial Law of Food Labeling and Advertising in 2016 limited child-directed creative content in any marketing and prohibited companies from placing TV ads for regulated products during programs attracting a child audience. In 2018, Chile extended this prohibition to a full “daytime” ban across all TV from 6 a.m. to 10 p.m. While researchers saw a decline in advertising for unhealthy foods during earlier phases of the law (in 2017 and early 2018), the significantly greater drop following the full daytime ban is noteworthy.

“Focusing on child-directed ad content and child-directed programming to reduce children’s exposure to unhealthy food advertising does work to an extent, based on what we’ve seen in Chile, but children are simply exposed to much more than this,” said Francesca Dillman Carpentier, PhD, W. Horace Carter Distinguished Professor at the UNC Hussman School of Journalism and Media and the study’s first author. “To markedly reduce the amount of unhealthy food promotions children view, we see that it takes a bold move like Chile’s 6 a.m. to 10 p.m. ban to be effective. The number of unhealthy food ads on TV, as well as kids’ exposure to them, was greatly reduced after Chile added the daytime ban on these ads.”

This study’s findings underscores a weakness of nearly all governmental restrictions on TV advertising for unhealthy foods worldwide: Most focus on very narrow windows of time or programming, leaving children exposed most of the day and night to targeted ads for unhealthy foods and drinks. (See below.) This study provides evidence that countries could significantly strengthen existing policies by expanding TV restrictions to complete bans. Countries considering introducing policies to regulate food marketing can also learn from the Chilean experience to protect children more effectively from ad exposure.

Chile enacted marketing controls in 2016 as part of an ambitious, comprehensive policy package aimed at reducing childhood obesity and other health risks by creating a healthier food environment. The Law of Food Labeling and Advertising also mandated “stop sign” warning labels on packages for unhealthy foods and banned their sale or promotion in schools. This remains one of the most ambitious regulatory frameworks in the world aimed at tackling rising nutrition-related diseases and soaring health care costs, and many policymakers and public health advocates worldwide have been watching to gauge the policy package’s effectiveness.

Other studies evaluating the combined effects of Chile’s marketing restrictions, warning labels and school ban have yielded similarly promising results: A study of household grocery purchases found a 24% drop in calories purchased in the first year (during the most lax period of the law’s three-phased nutritional criteria) and a 37% reduction in sodium purchased. Focus groups indicate that parents are being encouraged by their children to avoid buying foods with warning labels. Students reduced their sugar, saturated fat and sodium intake in schools — albeit with some evidence of compensation outside of school settings. And marketing restrictions also led to the removal of child-directed marketing strategies from nearly 50% of breakfast cereals to just 15% in the first year of the law.

“The Chilean experience has shown us that rigorous food marketing regulations work to reduce kids’ exposure to TV food advertising,” said co-author Lindsey Smith Taillie, PhD, associate professor and associate chair of academics in the Department of Nutrition at UNC-Chapel Hill’s Gillings Global School of Public Health.

“Looking to the future, we need to figure out how to monitor and regulate the digital food marketing environment, as kids increasingly shift their attention to smartphones and other online content.”

Lingering effects of Neanderthal DNA found in modern humans


Peer-Reviewed Publication

CORNELL UNIVERSITY



Recent scientific discoveries have shown that Neanderthal genes comprise some 1 to 4% of the genome of present-day humans whose ancestors migrated out of Africa, but the question remained open on how much those genes are still actively influencing human traits — until now.

A multi-institution research team including Cornell University has developed a new suite of computational genetic tools to address the genetic effects of interbreeding between humans of non-African ancestry and Neanderthals that took place some 50,000 years ago. (The study applies only to descendants of those who migrated from Africa before Neanderthals died out, and in particular, those of European ancestry.)

In a study published in eLife, the researchers reported that some Neanderthal genes are responsible for certain traits in modern humans, including several with a significant influence on the immune system. Overall, however, the study shows that modern human genes are winning out over successive generations. 

“Interestingly, we found that several of the identified genes involved in modern human immune, metabolic and developmental systems might have influenced human evolution after the ancestors’ migration out of Africa,” said study co-lead author April (Xinzhu) Wei, an assistant professor of computational biology in the College of Arts and Sciences. “We have made our custom software available for free download and use by anyone interested in further research.”

Using a vast dataset from the UK Biobank consisting of genetic and trait information of nearly 300,000 Brits of non-African ancestry, the researchers analyzed more than 235,000 genetic variants likely to have originated from Neanderthals. They found that 4,303 of those differences in DNA are playing a substantial role in modern humans and influencing 47 distinct genetic traits, such as how fast someone can burn calories or a person’s natural immune resistance to certain diseases.

Unlike previous studies that could not fully exclude genes from modern human variants, the new study leveraged more precise statistical methods to focus on the variants attributable to Neanderthal genes.

While the study used a dataset of almost exclusively white individuals living in the United Kingdom, the new computational methods developed by the team could offer a path forward in gleaning evolutionary insights from other large databases to delve deeper into archaic humans’ genetic influences on modern humans. 

“For scientists studying human evolution interested in understanding how interbreeding with archaic humans tens of thousands of years ago still shapes the biology of many present-day humans, this study can fill in some of those blanks,” said senior investigator Sriram Sankararaman, an associate professor at the University of California, Los Angeles. “More broadly, our findings can also provide new insights for evolutionary biologists looking at how the echoes of these types of events may have both beneficial and detrimental consequences.”

The other co-lead author on the study is Christopher Robles, postdoctoral researcher at UCLA. Additional authors are UCLA doctoral student Ali Pazokitoroudi; Andrea Ganna of Massachusetts General Hospital and the Broad Institute of MIT and Harvard; Alexander Gusev and Arun Durvasula of Harvard Medical School; Steven Gazal of USC; Po-Ru Loh of the Broad Institute of MIT and Harvard; and David Reich of Harvard University. 

The research was supported by grants from the National Institutes of Health and the National Science Foundation, with additional funding from an Alfred P Sloan Research Fellowship and a gift from the Okawa Foundation. Other authors received funding support from the Paul G. Allen Frontiers Group, the John Templeton Foundation, the Howard Hughes Medical Institute, the Burroughs Wellcome Fund and the Next Generation Fund at the Broad Institute of MIT and Harvard.

Why certain fish are left off the hook


New study finds that rhetoric about ‘underfishing’ in US waters may be misguided

Peer-Reviewed Publication

UNIVERSITY OF DELAWARE

Underfishing 

IMAGE: A NEW STUDY LED BY THE UNIVERSITY OF DELAWARE’S KIMBERLY OREMUS FOUND THAT WHILE THE MAGNUSON-STEVENS ACT — WHICH WAS MODERNIZED IN 1996 TO FOSTER THE LONG-TERM BIOLOGICAL AND ECONOMIC SUSTAINABILITY OF MARINE FISHERIES — IS SOMETIMES BLAMED FOR BEING TOO STRINGENT, LEADING TO WHAT SOME POLITICIANS CALL "UNDERFISHING," THE ACT IS NOT CONSTRAINING MOST FISHERIES, AND THERE ARE VARIOUS OTHER REASONS THAT LEAD TO CERTAIN FISH SPECIES BEING LESS FISHED. view more 

CREDIT: UNIVERSITY OF DELAWARE


As warming waters threaten fish populations and disrupt fisheries around the world, it is critical to find ways to sustain fisheries while at the same time allowing those fisheries to remain economically viable to those who depend on them for their livelihoods. In the United States, commercial fishing employs 1.2 million Americans and generates more than $165 billion annually. 

The primary way that the United States has protected its fisheries is through the Magnuson-Stevens Act, which was modernized in 1996 to foster the long-term biological and economic sustainability of marine fisheries. However, the reauthorization of this act has been stalled in Congress for a decade, as some politicians blame the law for being too stringent, leading to what they call
"underfishing."

The University of Delaware’s Kimberly Oremus recently served as a lead author on a paper published in Science that examined U.S. fishing policy. The paper found that the Magnuson-Stevens Act is not constraining most fisheries, and that there are various other reasons that lead to certain fish species being less fished. 

Oremus, assistant professor in the School of Marine Science and Policy, and Eyal Frank, an assistant professor at the University of Chicago Harris School of Public Policy, served as the lead authors on the paper. 

The researchers examined two decades of data on 170 U.S. fish stocks. These 170 managed fish stocks represent 85% of the U.S. marine commercial fish landings. 

In the study, Oremus, Frank, and their other co-authors examined the assertion of critics of U.S. fishing law that it is too stringent and unnecessarily leaves too many fish in the water. 

They found that the main reason about half of the fish stocks in the U.S. are considered "underfished" is due to pure economics — fishers are not harvesting the fish because there is not enough demand for them.

Just four fish species — the Eastern Bering Sea walleye pollock, Atlantic sea scallop, Gulf of Mexico brown shrimp and Gulf of Mexico white shrimp — make up the majority of the revenue of those stocks that the researchers characterized as potentially less utilized and fished. Of those, the majority of the revenue came from just one species: the walleye pollock, the catch of which is not constrained by the Magnuson-Stevens Act.

Other, healthy fish stocks are being left in the water because they could not be profitably caught without also catching other fish species that are depleted. 

“Some healthy stocks are constrained by the Magnuson-Stevens Act because they are often caught with other stocks that are depleted,” Oremus said. “Some stocks are constrained by other laws such as the Marine Mammal Protection Act or the Pacific Halibut Treaty with Canada. Some stocks are constrained by both market forces and policies, such as our Gulf of Mexico shrimp stocks that are struggling to compete with the price of imported shrimp coming from less regulated countries.”  

While political rhetoric has focused on laws that protect fisheries — such as the Magnuson-Stevens Act — as the main culprit in underfishing, the researchers said it is important to take a nuanced view of the picture and view fisheries on a case-by-case basis. 

“Targeting the Magnuson-Stevens Act will not change some of these outcomes,” Frank said. “It is important to understand the multitude of factors involved. Simply relaxing fishery management targets under the law will most likely fail to increase utilization in many of the marine fisheries that appear to be underutilized at face value.”

With changes to the environment and overfishing still a big concern in other parts of the world, it is critical to have science-based fisheries laws in place in order to sustain fish stocks moving forward, Oremus said. 

“On average, we find that less fished stocks were less fished six years before the law was passed in 1996, and their share of revenue has remained steady from 1990-2015,” Oremus said. “Though no law is perfect, the law appears to be attempting to balance the needs of fishers, other stakeholders, and the long-term conservation of the resource.”

For pet dogs, ‘running with the pack’ may be the best prevention to promote healthier living


Dog Aging Project survey of 21,000 dogs reveals more social support tied to healthier outcomes

Peer-Reviewed Publication

ARIZONA STATE UNIVERSITY

Getting to the heart of what makes 'dog years' 

IMAGE: THE DOG AGING PROJECT AIMS TO BETTER UNDERSTAND HEALTHIER AGING FOR PEOPLE’S BELOVED CANINE COMPANIONS. MORE THAN 45,000 DOGS OF ALL BREEDS AND SIZES HAVE ENROLLED IN THE STUDY. view more 

CREDIT: DOG AGING PROJECT, UNIVERSITY OF WASHINGTON


What exactly makes for a fit Fido? And how does a dog’s environment factor into their dog years?

 

“People love their dogs,” said ASU School of Life Sciences assistant professor Noah Snyder-Mackler.  “But what people may not know, is that this love and care, combined with their relatively shorter lifespans, make our companion dogs a great model for studying how and when aspects of the social and physical environment may alter aging, health and survival.”

 

Now, the largest survey and data compilation of its kind--- from more than 21,000 dog owners--- has revealed the social determinants that may be tied to healthier aging for people’s beloved canine companions. Among them, a measurement of the amount of a dog’s social support network proved to have the greatest influence and association on better health outcomes–5 times the effect of financial factors, household stability or the age of the owner.

 

Led by Snyder-Mackler, PhD student Bri McCoy, and MSc student Layla Brassington, they carried out a comprehensive analysis of a detailed survey of dog owners, which totaled a breathtaking number, 21,410 dogs. The study attempted to find key social aspects for healthy lifestyles to help explore the science behind dog years in a large, community-science endeavor called the Dog Aging Project. The Dog Aging Project is a partnership led by the University of Washington and Texas A&M schools of medicine that includes more than a dozen member institutions–including ASU–around the nation.

 

The main goal of the Dog Aging Project is to understand how genes, lifestyle, and the environment influence aging and disease outcomes. More than 45,000 dogs are now enrolled in the project across the U.S.

 

“This study illustrates the incredibly broad reach of the Dog Aging Project,” said Daniel Promislow, project co-director and principal investigator. “Here, we see how dogs can help us to better understand how the environment around us influences health, and the many ways in which dogs mirror the human experience. Just as with people, dogs in lower resource environments are more likely to have health challenges. Thanks to the richness of the data the Dog Aging Project is collecting, follow-up studies will have the potential to help us understand how and why environmental factors affect health in dogs.”

 

McCoy, Brassington, Snyder-Mackler, and team drew on a large survey that asked each owner questions about themselves and their pup: ranging from physical activity, environment, dog behavior, diet, medications and preventatives, health status, and owner demographics. Using these questions, they identified 5 key factors (neighborhood stability, total household income, social time with children, social time with animals, and owner age) that together, helped explained the makeup of a dog's social environment and were associated with dog wellbeing.

 

They found that the dog’s lived and built environment predicted their health, disease diagnoses, and physical mobility–even after controlling for the dog’s age and weight. More specifically: Financial and household adversity was linked to poorer health and reduced physical mobility, while ore social companionship, such as living with other dogs, was associated with better health. These effects of each environmental component were not equal: the effect of social support was 5 times stronger than financial factors.

 

“This does show that, like many social animals–including humans, having more social companions can be really important for the dog’s health,” said ASU graduate student McCoy.

 

Among the more surprising results were: 1) a negative association of the number of children in the household and dog health, and 2) that dogs from higher income households were diagnosed with more diseases.

 

“We found that time with children actually had a detrimental effect on dog health,” said Brassington. “The more children or time that owners dedicate to their children, likely leads to less time with their furry children.”

 

“You can think of it as a resource allocation issue, rather than kids being bad for dogs,” said McCoy.

 

The second counterintuitive finding points to the role that finance plays in the opportunities for disease diagnosis. Dogs from wealthier households have better access to medical care, leading inadvertantly to more disease diagnosis. Because the dogs who live in households with wealthier owners might seek veterinary care more frequently, and their owners have the funds to pay for additional tests, this leads to more diseases identified.

 

Their results remained largely consistent when accounting for health and diseases differences between pure and mixed breed dogs, as well as among specific breeds.

 

One important caveat and cautionary note on the data is due to the nature of surveys. Since these are owner-reported, there may be some error, bias, and/or misinterpretation of survey questions.

 

Their next steps will begin to explore if there are any links between the survey and underlying physiology.

“We now want to understand how these external factors are getting under the skin to affect the dog’s health–how is the environment altering their bodies and cells?,” said Snyder-Mackler.

 

A subset of the dogs, about 1,000 are part of a more focused cohort where Snyder-Mackler and his collaborators are collecting blood and other biological samples over many years to uncover these clues.

 

“In future research, we will look at electronic veterinary medical records, molecular and immunological measures, and at-home physical tests to generate more accurate measures of health and frailty in the companion dog,” said Snyder-Mackler.

 

“But the take home message is: Having a good network, having a good social connectedness is good for the dogs that are living with us,” said McCoy. “But the structure and equities that are in our society also have a detrimental effect on our companion animals as well. And they are not the ones thinking about their next paycheck or their health care.”

 

And what is good for dogs may just echo what may be a good prescription for people to live healthier lives.

“Overall, our study provides further evidence for the strong link between the social environment and health outcomes that reflects what is known for humans,” said Snyder-Mackler.  “We need to focus more attention to the role of the social environment on health and disease, and continued investigation of how each environmental factor can contribute to more years of healthy living (i.e., “healthspan”) in both companion dogs and humans.”

 

The study was published in the advanced online early edition of the journal Evolution, Medicine & Public Health.

Arizona State University School of Life Sciences MSc student Layla Brassington (left) and PhD student Bri McCoy (right), helped carry out a comprehensive analysis of a detailed survey of dog owners, which totaled a breathtaking number, 21,410 dogs. The study attempted to find key social aspects for healthy lifestyles to help explore the science behind dog years in a large, community-science endeavor called the Dog Aging Project.

CREDIT

Dr. Noah Snyder-Mackler, ASU School of Life Sciences