Saturday, October 28, 2023

Shape-shifting fiber can produce morphing fabrics


The low-cost FibeRobo, which is compatible with existing textile manufacturing techniques, could be used in adaptive performance wear or compression garments.


Peer-Reviewed Publication

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Actuating Fibers 

IMAGE: 

RESEARCHERS FROM MIT AND NORTHEASTERN UNIVERSITY DEVELOPED A LIQUID CRYSTAL ELASTOMER FIBER THAT CAN CHANGE ITS SHAPE IN RESPONSE TO THERMAL STIMULI. THE FIBER, WHICH IS FULLY COMPATIBLE WITH EXISTING TEXTILE MANUFACTURING MACHINERY, COULD BE USED TO MAKE MORPHING TEXTILES, LIKE A JACKET THAT BECOMES MORE INSULATING TO KEEP THE WEARER WARM WHEN TEMPERATURES DROP.

view more 

CREDIT: IMAGE COURTESY OF JACK FORMAN, ET AL




CAMBRIDGE, Mass. -- Instead of needing a coat for each season, imagine having a jacket that would dynamically change shape so it becomes more insulating to keep you warm as the temperature drops.

A programmable, actuating fiber developed by an interdisciplinary team of MIT researchers could someday make this vision a reality. Known as FibeRobo, the fiber contracts in response to an increase in temperature, then self-reverses when the temperature decreases, without any embedded sensors or other hard components. 

The low-cost fiber is fully compatible with textile manufacturing techniques, including weaving looms, embroidery, and industrial knitting machines, and can be produced continuously by the kilometer. This could enable designers to easily incorporate actuation and sensing capabilities into a wide range of fabrics for myriad applications, such as programmable compression garments that could aid in post-surgery recovery. 

The fibers can also be combined with conductive thread, which acts as a heating element when electric current runs through it. In this way, the fibers actuate using electricity, which offers a user digital control over a textile’s form. For instance, a fabric could change shape based on any piece of digital information, such as readings from a heart rate sensor.

“We use textiles for everything. We make planes with fiber-reinforced composites, we cover the International Space Station with a radiation-shielding fabric, we use them for personal expression and performance wear. So much of our environment is adaptive and responsive, but the one thing that needs to be the most adaptive and responsive — textiles — is completely inert,” says Jack Forman, a graduate student in the Tangible Media Group and the Center for Bits and Atoms in the MIT Media Lab, and lead author of a paper on the actuating fiber.

He is joined on the paper by 11 other researchers at MIT and Northeastern University, including his advisors, Professor Neil Gershenfeld, who leads the Center for Bits and Atoms, and Hiroshi Ishii, the Jerome B. Wiesner Professor of Media Arts and Sciences and director of the Tangible Media Group. The research will be presented at the ACM Symposium on User Interface Software and Technology.

Morphing materials

Current shape-changing fibers have pitfalls that have largely prevented them from being incorporated into textiles beyond laboratory settings. 

One fiber, known as a shape-changing alloy, only contracts by about 5 percent, doesn’t self-reverse, and often stops working after a handful of actuations. Another, called a McKibben actuator, is pneumatically driven and requires an air compressor to actuate.

The MIT researchers wanted a fiber that could actuate silently and change its shape dramatically, while being compatible with common textile manufacturing procedures. To achieve this, they used a material known as liquid crystal elastomer (LCE).

A liquid crystal is a series of molecules that can flow like liquid, but when they’re allowed to settle, they stack into a periodic crystal arrangement. The researchers incorporate these crystal structures into an elastomer network, which is stretchy like a rubber band.

As the LCE material heats up, the crystal molecules fall out of alignment and pull the elastomer network together, causing the fiber to contract. When the heat is removed, the molecules return to their original alignment, and the material to its original length, Forman explains.

By carefully mixing chemicals to synthesize the LCE, the researchers can control the final properties of the fiber, such as its thickness or the temperature at which it actuates. 

They perfected a preparation technique that creates LCE fiber which can actuate at skin-safe temperatures, making it suitable for wearable fabrics. Researchers had been unable to accomplish this with other LCE fibers, Forman says.

“There are a lot of knobs we can turn. It was a lot of work to come up with this process from scratch, but ultimately it gives us a lot of freedom for the resulting fiber,” he adds. 

However, the researchers discovered that making fiber from LCE resin is a finicky process. Existing techniques often result in a fused mass that is impossible to unspool.

Researchers are also exploring other ways to make functional fibers, such as by incorporating hundreds of microscale digital chips into a polymer, utilizing an activated fluidic system, or including piezoelectric material that can convert sound vibrations into electrical signals.

Fiber fabrication

Forman built a machine using 3D-printed and laser-cut parts and basic electronics to overcome the fabrication challenges. He initially built the machine as part of the graduate-level course MAS.865 (Rapid-Prototyping of Rapid-Prototyping Machines: How to Make Something that Makes (almost) Anything).

To begin, the thick and viscous LCE resin is heated, and then slowly squeezed through a nozzle like that of a glue gun. As the resin comes out, it is cured carefully using UV lights that shine on both sides of the slowly extruding fiber.

If the light is too dim, the material will separate and drip out of the machine, but if it is too bright, clumps can form, which yields bumpy fibers.

Then the fiber is dipped in oil to give it a slippery coating and cured again, this time with UV lights turned up to full blast, creating a strong and smooth fiber. Finally, it is collected into a top spool and dipped in powder so it will slide easily into machines for textile manufacturing. 

From chemical synthesis to finished spool, the process takes about a day and produces approximately a kilometer of ready-to-use fiber. 

“At the end of the day, you don’t want a diva fiber. You want a fiber that, when you are working with it, falls into the ensemble of materials — one that you can work with just like any other fiber material, but then it has a lot of exciting new capabilities,” Forman says.

Creating such a fiber took a great deal of trial and error, as well as the collaboration of researchers with expertise in many disciplines, from chemistry to mechanical engineering to electronics to design. 

The resulting fiber, called FibeRobo, can contract up to 40 percent without bending, actuate at skin-safe temperatures, and be produced with a low-cost setup for 20 cents per meter, which is about 60 times cheaper than commercially available shape-changing fibers.

The fiber can be incorporated into industrial sewing and knitting machines, as well as nonindustrial processes like hand looms or manual crocheting, without the need for any process modifications.

The MIT researchers used FibeRobo to demonstrate several applications, including an adaptive sports bra made by embroidery that tightens when the user begins exercising. 

They also used an industrial knitting machine to create a compression jacket for Forman’s dog, whose name is Professor. The jacket would actuate and “hug” the dog based on a Bluetooth signal from Forman’s smartphone. Compression jackets are commonly used to alleviate the separation anxiety a dog can feel while its owner is away.

In the future, the researchers want to adjust the fiber’s chemical components so it can be recyclable or biodegradable. They also want to streamline the polymer synthesis process so users without wet lab expertise could make it on their own. 

Forman is excited to see the FibeRobo applications other research groups identify as they build on these early results. In the long run, he hopes FibeRobo can become something a maker could buy in a craft store, just like a ball of yarn, and use to easily produce morphing fabrics.

This research was supported, in part, by the William Asbjornsen Albert Memorial Fellowship, the Dr. Martin Luther King Jr. Visiting Professor Program, Toppan Printing Co., Honda Research, Chinese Scholarship Council, and Shima Seiki. The team included Ozgun Kilic Afsar, Sarah Nicita, Rosalie (Hsin-Ju) Lin, Liu Yang, Akshay Kothakonda, Zachary Gordon, and Cedric Honnet at MIT; and Megan Hofmann and Kristen Dorsey at Northeastern University.

###

Written by Adam Zewe, MIT News

Paper: “FibeRobo: Fabricating 4D Fiber Interfaces by Continuous Drawing of Temperature Tunable Liquid Crystal Elastomers”

https://dl.acm.org/doi/10.1145/3586183.3606732

 

Interacting polarons


Physicists simulate interacting quasiparticles in ultracold quantum gas


Peer-Reviewed Publication

UNIVERSITY OF INNSBRUCK

Interacting polarons 

IMAGE: 

POTASSIUM ATOMS (YELLOW) SURROUNDED BY LITHIUM ATOMS (BLUE) FORM POLARONS THAT INTERACT WITH EACH OTHER.

view more 

CREDIT: IQOQI INNSBRUCK/HARALD RITSCH




An electron moving through a solid generates a polarization in its environment due to its electric charge. In his theoretical considerations, the Russian physicist Lev Landau extended the description of such particles by their interaction with the environment and spoke of quasiparticles. More than ten years ago, the team led by Rudolf Grimm at the Institute of Quantum Optics and Quantum Information (IQQOI) of the Austrian Academy of Sciences (ÖAW) and the Department of Experimental Physics of the University of Innsbruck succeeded in generating such quasiparticles for both attractive and repulsive interactions with the environment. For this purpose, the scientists use an ultracold quantum gas consisting of lithium and potassium atoms in a vacuum chamber. With the help of magnetic fields, they control the interactions between the particles, and by means of radio-frequency pulses push the potassium atoms into a state in which they attract or repel the lithium atoms surrounding them. In this way, the researchers simulate a complex state similar to the one produced in the solid state by a free electron.

A Closer Look at Solids

Now, the scientists led by Rudolf Grimm have been able to generate several such quasiparticles simultaneously in the quantum gas and observe their interactions with each other. „In a naive notion, one would assume that polarons always attract each other, regardless of whether their interaction with the environment is attractive or repulsive,” says the experimental physicist. „However, this is not the case. We see attractive interaction in bosonic polarons, repulsive interaction in fermionic polarons. Here, quantum statistics plays a crucial role.” The researchers have now been able to demonstrate this behavior, which in principle already follows as a consequence of Landau's theory, in an experiment for the first time. The theoretical calculations for this were done by colleagues from Mexico, Spain and Denmark. „High experimental skills were required to implement this in the laboratory”, explains Cosetta Baroni, first author of the study, “because even the smallest deviations could have skewed the measurements.”

“Such investigations provide us with insights into very fundamental mechanisms of nature and offer us excellent opportunities to study them in detail,” says Rudolf Grimm excitedly.

 

A large international study of migraine reveals new biological pathways for treatment


Peer-Reviewed Publication

DECODE GENETICS

Kari Stefansson and Gyda Bjornsdottir 

IMAGE: 

KARI STEFANSSON CEO OF DECODE GENETICS AND GYDA BJORNSDOTTIR LEADER OF THE PROJECT ON BEHALF OF DECODE GENETICS.

view more 

CREDIT: DECODE GENETICS




Reykjavik, 26. October 2023.

A large international study led by deCODE Genetics on the genetics of migraine provides novel insights into the biology of migraine enabling detection of rare variants protecting against migraine, opening an avenue for potential development of novel drug targets.
In a study published today in Nature Genetics  a group of international scientists led by deCODE Genetics in Iceland, a subsidiary of Amgen Inc, analyzed genetic data from over 1,3 million participants of which 80 thousand had migraine. The scientists focused on detecting sequence variants associated with the the two main subtypes of migraine: migraine with aura (often referred to as classical migraine) and migraine without aura. The results highlight several genes that affect one of these migraine subtypes over the other, and point to new biological pathways that could be targeted for therapeutic developments.

Migraine is among the most common chronic pain disorders worldwide, with up to 20% of adults affected. Although recent advances have been made in studies of the genetics and underlying biology of migraine and new treatments recently developed that are effective for many migraine sufferers, they do not work for all types of migraine

The study revealed associations with 44 variants, 12 of which are novel. Four novel migraine with aura associations were revealed and 13 variants associated primarily with migraine without aura. Of particular interest were three rare variants with large effects pointing to distinct pathologies underlying different types of migraine. Thus, a rare frameshift variant in the PRRT2 gene confers a large risk of migraine with aura and with another brain disease, epilepsy, but not of migraine without aura. In SCN11A, a gene known to play a key role in pain sensation, the scientists detected several rare loss-of-function variants associated with protection effects against migraine, while a common missense variant in the same gene is associated with modest risk of migraine. Finally, a rare variant pointing to the KCNK5 gene, confers large protection against severe migraine and brain aneurysms, either identifying a common pathway between the two diseases or suggesting that some cases of early brain aneuryisms may be misclassified as migraine.  „What makes our study unique is that it includes large datasets from sequenced individuals enabling detection of rare variants protecting against migraine, potentially opening an avenue for development of novel drug targets,“ says Kari Stefansson CEO of deCODE genetics..

The joint effort of the international research team was led by scientists at deCODE genetics in Iceland and included collaborating scientists from the Copenhagen Hospital Biobank and Danish Blood Bank Study, the HUSK study in Norway, the Intermountain Health study in the US, and data generated by the large population-based studies from the UK Biobank and FinnGen.

--------

Based in Reykjavik, Iceland, deCODE is a global leader in analyzing and understanding the human genome. Using its unique expertise and population resources, deCODE has discovered genetic risk factors for dozens of common diseases. The purpose of understanding the genetics of disease is to use that information to create new means of diagnosing, treating and preventing disease. deCODE is a wholly-owned subsidiary of Amgen (NASDAQ:AMGN).

 

To navigate the world, we all shimmy like these electric fish


Peer-Reviewed Publication

JOHNS HOPKINS UNIVERSITY

Electric Knifefish in Observation Tank 

VIDEO: 

AN OBSERVATION TANK ILLUMINATED BY INFRARED SHOWS ELECTRIC KNIFEFISH BEHAVIOR WITH THE LIGHTS ON (TOP) AND LIGHTS OFF (BOTTOM).

view more 

CREDIT: JOHNS HOPKINS UNIVERSITY.




An electric knifefish shimmies in the water for the same reason a dog sniffs or a human glances around a new place — to make sense of their surroundings. For the first time, scientists demonstrate that a wide range of organisms, even microbes, perform the same pattern of movements in order to sense the world.

“Amoeba don’t even have a nervous system, and yet they adopt behavior that has a lot in common with a human’s postural balance or fish hiding in a tube,” said author Noah Cowan, a professor of mechanical engineering at Johns Hopkins. “These organisms are quite far apart from each other in the tree of life, suggesting that evolution converged on the same solution through very different underlying mechanisms.”

The research, which has implications for cognition and robotics, is published in Nature Machine Intelligence.

The findings stem from the team’s efforts to figure out what the nervous system does when animals move to improve their perception of the world, and whether that behavior could be translated to robotic control systems.

While watching electric knifefish in an observation tank, the researchers noticed how when it was dark, the fish shimmied back and forth significantly more frequently. When lights were on, the fish swayed gently with only occasional bursts of rapid movement.

Knifefish in the wild are hardwired to find refuge to avoid predators. They emit weak electric discharges to sense their location and find shelter. Wiggling rapidly allows them to actively sense their surroundings, especially in dark water. In the light, they still make such rapid movements, just far less frequently.

“We found that the best strategy is to briefly switch into explore mode when uncertainty is too high, and then switch back to exploit mode when uncertainty is back down,” said first author Debojyoti Biswas, a Johns Hopkins postdoctoral researcher.

This is the first time scientists deciphered this mode-switching strategy in fish. It’s also the first time anyone has linked this behavior across species.

The team created a model that simulates the key sensing behaviors, and using work from other labs, spotted the same sensory dependent movements in other organisms. Creatures that shared the behavior with the fish included amoeba, moths, cockroaches, moles, bats, mice, and humans.

“Not a single study that we found in the literature violated the rules we discovered in the electric fish, not even single-celled organisms like amoeba sensing an electric field,” Cowan said.

Scientists are just beginning to understand how animals control sensing movements unconsciously. The team suspects all organisms have a brain computations that manage uncertainty.

“If you go to a grocery store, you’ll notice people standing in line will change between being stationary and moving around while waiting,” Cowan said. “We think that’s the same thing going on, that to maintain a stable balance you actually have to occasionally move around and excite your sensors like the knifefish. We found the statistical characteristics of those movements are ubiquitous across a wide range of animals, including humans.”

The team expects the findings can be used to improve search and rescue drones, space rovers, and other autonomous robots.

Next they will test whether their insights hold true for other living things — even plants.

Authors include Andrew Lamperski of University of Minnesota Minneapolis; Yu Yang of Johns Hopkins; Kathleen Hoffman of University of Maryland, Baltimore County; John Guckenheimer of Cornell University; and Eric S. Fortune of New Jersey Institute of Technology.

 

How do animals know it’s lunchtime?


Scientists discover molecular pathways that fix mealtimes and how they sync to days


Peer-Reviewed Publication

TOKYO METROPOLITAN UNIVERSITY

Molecular mechanisms behind regular feeding cycles in fruit flies. 

IMAGE: 

THE TEAM FOUND THAT QSM REGULATED SYNCING TO LIGHT/DARK CYCLES WHILE MOLECULAR CLOCKS IN NEURONS TOOK OVER THE ROLE IN CONSTANT DARKNESS. ON THE OTHER HAND, CLK/CYC GENES HELPED KEEP FEEDING/FASTING CYCLES.

view more 

CREDIT: TOKYO METROPOLITAN UNIVERSITY




Tokyo, Japan – Researchers from Tokyo Metropolitan University have used fruit flies to study how daily eating patterns are regulated. They found that the quasimodo (qsm) gene helped sync feeding to light/dark cycles, but not in constant darkness: instead, the genes clock (clk) and cycle (cyc) keep eating/fasting cycles, while other “clocks” in nerve cells help sync it to days. Deciphering the molecular mechanism behind eating cycles helps us understand animal behavior, including our own.

Many members of the animal kingdom eat at roughly the same times each day. This is born out of the need to adapt to aspects of the environment, including how much light there is, temperature, the availability of food, the chance that predators are around, all of which are vital for survival. It is also important for efficient digestion and metabolism, thus for our general wellbeing.

But how do such a wide range of organisms know when to eat? An important factor is circadian rhythm, an approximately daily physiological cycle shared by organisms as diverse as animals, plants, bacteria and algae. It serves as a “master clock” which regulates rhythmic behavior. But animals are full of other timing mechanisms, known as “peripheral clocks,” each with its own different biochemical pathways. These can be reset by external factors, such as feeding. But the specific way in which these clocks govern animal feeding behavior is not yet clear.

Now a team led by Associate Professor Kanae Ando of Tokyo Metropolitan University have addressed this problem using fruit flies, a model organism that mirrors many of the features of more complex animals, including humans. They used a method known as a CAFE assay, where flies are fed through a microcapillary to measure exactly how much individual flies eat at different times. Firstly, they looked at how flies synced their eating habits to light. Studying flies feeding in a light/dark cycle, previous work already showed that flies feed more during the daytime even when mutations were introduced to core circadian clock genes, period (per) and timeless (tim). Instead, the team looked at quasimodo (qsm), a gene that encodes for a light-responsive protein that controls the firing of clock neurons. By knocking down qsm, they found that flies had their daytime feeding pattern significantly affected. For the first time, we know that the syncing of feeding to a light-mediated rhythm is affected by qsm.

This was not the case for flies feeding in constant darkness. Flies with mutations in their core circadian clock genes suffered severe disruption to their daily feeding patterns. Of the four genes involved, period (per), timeless (tim), cycle (cyc) and clock (clk), loss of cyc and clk was far more severe. In fact, it was found that clk/cyc was necessary in creating bimodal feeding patterns i.e. eating and fasting periods, particularly those in metabolic tissues. But how did these cycles sync up with days? Instead of metabolic tissues, molecular clock genes in the nerve cells played the dominant role.

The team’s discoveries give us a first glimpse into how different clocks in different parts of an organism regulate feeding/fasting cycles as well as how they match up with diurnal rhythms. An understanding of the mechanisms behind feeding habits promises new insights into animal behavior, as well as novel treatments for eating disorders.

This work was supported by the Farber Institute for Neurosciences and Thomas Jefferson University, the National Institutes of Health [R01AG032279-A1], a Takeda Foundation Grant, and the TMU Strategic Research Fund.

 

Study shows simple diet swaps can cut carbon emissions and improve your health


Making one small diet change -- chicken instead of beef, plant milk instead of cow's milk -- could significantly curb carbon emissions and increase the healthfulness of your diet.


Peer-Reviewed Publication

TULANE UNIVERSITY




Curbing carbon emissions and eating healthier may both start at the dinner table.

According to a new study co-authored by a Tulane University researcher and published in the journal Nature Food, making simple substitutions like switching from beef to chicken or drinking plant-based milk instead of cow’s milk could reduce the average American’s carbon footprint from food by 35%, while also boosting diet quality by between 4-10%, according to the study.

These findings highlight the potential of a “small changes” approach that researchers believe could encourage more consumers to adopt climate-friendly eating habits. Food production accounts for 25-33% of the nation’s greenhouse gas emissions with beef production being a primary contributor.

“This study shows that cutting dietary carbon emissions is accessible and doesn’t have to be a whole lifestyle change,” said Diego Rose, senior author and nutrition program director at Tulane University School of Public Health and Tropical Medicine. “It can be as simple as ordering a chicken burrito instead of a beef burrito when you go out to eat. When you’re at the grocery store, move your hand one foot over to grab soy or almond milk instead of cow’s milk. That one small change can have a significant impact.”

 

The study, which analyzed diet data from over 7,700 Americans, identified commonly eaten foods with the highest climate impact and simulated replacing them with nutritionally similar, lower-emission options.

“For us, substitutes included swapping a beef burger for a turkey burger, not replacing your steak with a tofu hotdog,” said Anna Grummon, lead author and assistant professor of pediatrics and health policy at Stanford University. “We looked for substitutes that were as similar as possible.”

The largest projected reductions in emissions were seen in mixed dishes: burritos, pastas and similar popular dishes where it’s easy to substitute a lower-impact protein instead of beef.

The study expanded on past research by including dietary data for children. Whereas it may be more effective for an adult to focus on protein swaps, Grummon said switching children to plant-based milk can have a “meaningful impact on the carbon footprint” and help start positive habits earlier.

Identifying healthy alternatives to high-carbon foods was not the intent of the study. And yet, swapping to lower carbon foods showed “sizable improvements in how healthy the diets were.”

While these substitutes are not intended as a cure-all for climate objectives or personal health goals, they are evidence that small changes can have a large impact.

“There is overlap between sustainable diets and healthy diets,” Grummon said. “Our study shows that changing just one ingredient, making one swap, can be a win-win, resulting in meaningful changes in both climate outcomes and how healthy our diets are.”

Other co-authors of the study included Cristina Lee and Thomas Robinson of Stanford University and Eric Rimm of Harvard University.

 

Stunting in infancy linked to differences in cognitive and brain function


Peer-Reviewed Publication

UNIVERSITY OF EAST ANGLIA




Children who are too short for their age can suffer reduced cognitive ability arising from differences in brain function as early as six months of age, according to new research from the University of East Anglia.

Researchers compared the ‘visual working memory’ – the memory capacity that holds visual cues for processing – in children who had stunted growth with those having typical growth.

Published today in the journal Nature Human Behaviour, the study found that the visual working memory of infants with poor physical growth was disrupted, making them more easily distracted and setting the stage for poorer cognitive ability one year later.

Stunted growth had previously been linked with poor cognitive outcomes later in life, but this is the first time that this association has been found in infancy. It is also the first time stunted growth has been linked to functional differences in how the brain works in early development.

Led by Prof John Spencer of UEA’s School of Psychology, the team of researchers studied more than 200 children in the first ever brain imaging study of its kind.

“We expected that poor growth might impact cognition in early development, but it was striking to see this at the level of brain function,” said Prof Spencer.

“Typically-developing infants in our study showed engagement of a working memory brain network - and this brain activity predicted cognitive outcomes one year later. But the stunted infants showed a very different pattern suggesting that they were quite distractable.”

“This distractability was associated with a brain network typically involved in the allocation of attention to objects or tasks, suppressing distraction, and maintaining items in working memory” said Dr Sobana Wijeakumar, first author of the study. Dr. Wijeakumar is an Assistant Professor in the School of Psychology at the University of Nottingham.

The brain activity and cognitive abilities of the infants were assessed at six to nine months, and cognitive ability was followed up one year later. The results showed that infants with so-called ‘stunted growth’, often caused by poor nutrition or ill-health, had significantly poorer cognitive abilities at both stages than their typically-developing counterparts.

Interestingly, the children who bucked the trend and did well in their second year of cognitive testing despite having restricted growth were those whose visual memory had been unexpectedly strong at the six to nine months stage.  

The discovery suggests that efforts to improve working memory and tackle distractibility in children during their crucial early months may reduce or prevent cognitive disadvantages later in life. This research also highlights the importance of studying brain function in early development.

The research was led by the University of East Anglia in collaboration with the University of Nottingham, the Community Empowerment Lab, Durham University, University of Iowa, Rhode Island Hospital, Brown University, and the Bill & Melinda Gates Foundation.

‘Stunting in infancy is associated with atypical activation of working memory and attention networks’ is published by Nature Human Behaviour.

This publication is based on research funded in part by the Bill & Melinda Gates Foundation. The findings and conclusions contained within are those of the authors and do not necessarily reflect positions or policies of the Bill & Melinda Gates Foundation.

Further funding came from the US National Institutes of Health and the Leverhulme Trust.

ENDS

EDITOR’S NOTES

1/ For more information or to request an interview, please contact the UEA communications office at communications@uea.ac.uk.

Prof John Spencer: j.spencer@uea.ac.uk

2/ A copy of the paper can be downloaded from the following Dropbox link: https://www.dropbox.com/scl/fo/x25r6jbwrpn853872xtkw/h?rlkey=0sbx2in5igaamnmub0ut6lc2l&dl=0

The DOI number for this paper will be 10.1038/s41562-023-01725-3. Once the paper has been published online, it will be available at the following URL: https://www.nature.com/articles/s41562-023-01725-3. This link will go live after the embargo ends.

3/ The University of East Anglia (UEA) is a UK Top 25 university (Complete University Guide and HESA Graduate Outcomes Survey) and a UK Top 30 university in the Sunday Times Good University Guide. It also ranks in the UK Top 20 for research quality (Times Higher Education REF2021 Analysis) and the UK Top 10 for impact on Sustainable Development Goals. Known for its world-leading research and good student experience, its 360-acre campus has won seven Green Flag awards in a row for its high environmental standards. The University is a leading member of Norwich Research Park, one of Europe’s biggest concentrations of researchers in the fields of environment, health and plant science. www.uea.ac.uk.