Pennington Biomedical study to explore effects of soy on blood sugar levels

Recruiting is underway for adults and seniors in MOTIVATE study

Pennington Biomedical Research Center

Pennington Biomedical Research Center’s Dr. Candida Rebello wants to know more about the intersection of blood sugar levels and a diet rich in soy. This intersection is the primary focus of her new study, “Lifestyle Intervention for Improving Metabolic and Motivational Outcomes,” or MOTIVATE, which explores how specific diets can impact blood sugar, and potentially improve mood and energy levels.  

When soy seeds are cut, they produce the anti-microbial compound known as glyceollin, which has been shown to improve insulin sensitivity and cognition. The cut soy seeds will be milled into flour and will be included in the diets of some of the participants. The MOTIVATE study is open to adults aged 50 to 75 years who feel that they have low energy levels, lack motivation, and have a body mass index of 30 or greater. The study will last approximately 12 weeks, and meals are provided to participants at no cost. 

“Soy is widely recognized for its health benefits, and my research is focused on studying the effects of soybeans that have been activated to produce a component that the plant uses to protect itself,” said Dr. Rebello, who is the Director of the Nutrition and Chronic Disease Program at Pennington Biomedical. “I’m particularly interested in understanding how this form of soy, when integrated into a healthy diet, influences blood sugar. The MOTIVATE study will examine the impact of a healthy eating plan and exercise on blood sugar, mood, and energy levels.” 

Qualified participants will undergo a screening process before being enrolled in the study. Once in the study, participants will be provided with a diet and exercise regimen and will be required to visit the Center three days per week for exercise and to collect their meals over the study’s duration. Study participants will be segmented into groups, with some receiving the meals that do contain soy, and others receiving meals that do not contain soy.  

During these visits, participants will provide test administrators with their medical histories, height and weight measurements, and vital signs. The study also includes physical examination, insulin sensitivity test, electrocardiogram and a DXA scan to measure bone density, muscle, and body fat. 

"At Pennington Biomedical, we are putting science to work for a healthier Louisiana, and as we age, healthier can mean being more alert, energetic and motivated,” said Dr. John Kirwan, Executive Director of Pennington Biomedical. “Dr. Rebello’s MOTIVATE study will explore the hidden benefits of soy on mood and energy levels, and we are counting on Louisiana residents to join the study and help us uncover new insights.” 

In addition to being provided with all meals, MOTIVATE study participants will receive compensation of up to $660 for the study. To confirm eligibility, or to apply to participate, visit www.pbrc.edu/motivate, call 225-763-3000, or email clinicaltrials@pbrc.edu. This research is supported by the National Institute on Aging under award number R00AG065419. 

About the Pennington Biomedical Research Center

The Pennington Biomedical Research Center is at the forefront of medical discovery as it relates to understanding the triggers of obesity, diabetes, cardiovascular disease, cancer and dementia. The Center conducts basic, clinical, and population research, and is a campus of the LSU System. The research enterprise at Pennington Biomedical includes over 530 employees within a network of 44 clinics and research laboratories, and 13 highly specialized core service facilities. Its scientists and physician/scientists are supported by research trainees, lab technicians, nurses, dietitians, and other support personnel. Pennington Biomedical is a state-of-the-art research facility on a 222-acre campus in Baton Rouge. For more information, see www.pbrc.edu.