Wednesday, February 15, 2023

Higher ed institutions, STEMM organizations should act to change cultures to support inclusive excellence and dismantle barriers created by systemic racism and implicit bias


Reports and Proceedings

NATIONAL ACADEMIES OF SCIENCES, ENGINEERING, AND MEDICINE

Feb. 14, 2023

Higher Ed Institutions, STEMM Organizations Should Act to Change Cultures to Support Inclusive Excellence and Dismantle Barriers Created by Systemic Racism and Implicit Bias

WASHINGTON – To increase diversity, equity, and inclusion in STEMM fields, higher education institutions and STEMM organizations should go beyond a focus on simply increasing the numeric participation of minoritized racial and ethnic groups and act to change their organizational cultures and environments, says a new report from the National Academies of Sciences, Engineering, and Medicine.

Removing barriers to entry and participation, while also implementing practices that convey belonging, will allow organizations to move from broadening participation by the numbers to fostering a culture of inclusion, thriving, and success, the report says. Organizations should take active, intentional steps to dismantle policies, practices, and cultures that confer power and privilege to White people over others.

“The concepts of antiracism, diversity, equity, and inclusion are not goals for which a simple checklist will indicate success,” said Gilda Barabino, president of Olin College of Engineering and professor of biomedical and chemical engineering, and co-chair of the committee that wrote the report. “Rather, the goal is to create environments that focus on inclusive excellence, where all participants have access to educational and professional opportunities, feel included, and have the resources to actualize their full potential. STEMM organizations will require ongoing leadership, resources, and commitment to ensure that these values become part of an intentionally maintained organizational culture.”

The report recommends that organizations follow a multitiered approach – at the leadership, team, and individual levels – and identifies policies and practices that can be implemented at each level.

While people from minoritized groups comprise a growing part of the U.S. population, that growth has not been mirrored by similar increases in STEMM education and careers among these groups, the report notes. The root cause of these gaps does not reflect the abilities or interests of individuals; rather, evidence shows that minoritized individuals have faced numerous systemic barriers, including macro-level policies and practices that have negatively impacted their access, representation, and ability to thrive in STEMM careers.  Racial bias at the individual and interpersonal levels also impedes STEMM careers for people from minoritized groups.

“The history of systemic racism in the United States -- both written laws and policies and a culture of practices and beliefs -- has harmed Black people, Indigenous people, Latine, Asian American, and other people from minoritized racial and ethnic groups, ingrained patterns that continue to this day,” said committee co-chair Susan Fiske, Eugene Higgins Professor of Psychology and Public Affairs at Princeton University. “STEMM organizations operate within that broader national history, which provides critical context for understanding the unequal representation of minoritized populations in STEMM higher education and workplaces.”

“The committee has identified strong and needed actions that all STEMM organizations – including our own – could take to fight racism and embrace antiracism strategies that expand our focus beyond increasing numeric diversity to ensuring that everyone has the support and resources they need to succeed and thrive,” National Academy of Sciences President Marcia McNutt, National Academy of Engineering President John L. Anderson, and National Academy of Medicine President Victor J. Dzau said jointly. “We hope this report will spark a decisive turning point for advancing diversity, equity, inclusion, and antiracism in science, engineering, and medicine.  We look forward to joining forces with other STEMM leaders to foster effective, meaningful change across the research enterprise.”

Organizations need multitiered strategies

The report recommends that organizations implement changes to policies and practices at the individual, team, and organization levels.  

Individual level. Gatekeepers — individuals in institutions or organizations who are in a position to permit or prevent access to resources — play an important role in determining who is and who is not included in STEMM by defining the skills, identities, and values necessary for individuals to persevere in these fields. Research indicates that most often in STEMM, non-Hispanic White males occupy the gatekeeper role.

Like other people, gatekeepers often have attitudinal biases, cognitive mechanisms, and social motives that keep the White status quo intact, the report says. Racial bias is not only more automatic but also more ambivalent and ambiguous than most people think; this means that individuals, including gatekeepers, may not be able to monitor their own bias impartially, and may unwittingly perpetuate it.

The report recommends generating systems of accountability that can help identify behavioral patterns of individual gatekeepers. For example, leaders of STEMM organizations and human resources directors can create organization-level or unit-level information systems to collect data on the decisions of gatekeepers related to hiring, admissions, promotion, tenure, advancement, and awards, and other factors. Data should be examined in the aggregate to identify patterns of bias exhibited by gatekeepers based on race and ethnicity.

Team level. Most science today relies on scientists training or working together in teams of varying sizes. While a common narrative is that diverse teams perform better, simply having a numerically diverse team does not automatically result in positive performance outcomes, the report says. Numerous challenges can threaten performance, including anxiety about working with people from other racial and ethnic groups, and prevalent mistreatment targeting minoritized individuals.

Conditions that foster inclusion are essential, the report says. Gatekeepers who manage teams, such as principal investigators and heads of research groups, should be intentional about creating team norms that centralize a positive climate in which all team members, including minoritized individuals, are supported, heard, and respected. They should develop interdependent teams in which everyone is cooperating and working toward an established common goal. They should ensure that team members feel psychologically safe on the team, and work to promote equal status among team members.  

Organizational and leadership level.  Leaders, notably those at the very top of the organization such as presidents and chief executive officers, have the unique opportunity to shape organizational culture and climate by (re)shaping the norms, values, policies, and practices that comprise that culture and climate.  To make large-scale change, leaders need to set an agenda that addresses the organization at multiple levels, including gatekeepers, leaders, midlevel management, and administration, with the appropriate resources in terms of person hours and funds.

Leaders should review evaluation criteria and decision-making practices at critical points of access and advancement – such as in admissions, hiring and wages, start-up resource-setting, and promotion -- and take action to redress both individual bias and discrimination and organizational processes that reproduce harm and negative outcomes for people from minoritized racial and ethnic groups. For example:

  • Admissions offices at the undergraduate and graduate levels should assess the alignment or divergence between their current admissions policies and the criteria and values of antiracism, diversity, equity, and inclusion. They should develop holistic admissions strategies that offer a systematic, contextualized evaluation of applicants on multiple dimensions.
  • Hiring managers, directors of human resources, and supervisors should measure and review the application, offer, and acceptance rates in their organization, as well as the salaries, resource packages, and academic tracks and titles of new hires, for instances of racial and ethnic discrimination in the hiring process. These leaders should implement, as appropriate, proactive outreach and recruitment to increase applications from people from minoritized racial and ethnic groups; training and resources to eliminate bias in the hiring process for managers; and updated policies to reduce bias and discrimination in setting wages.
  • Directors of human resources and supervisors should measure, evaluate, and address the presence of bias and discrimination in rewards and promotion; the proportion of people from historically minoritized backgrounds leaving their positions and their reasons for doing so; and access to culturally relevant mentorship for students and employees.

The report urges predominantly White institutions of higher education and other STEMM organizations to look to historically Black colleges and universities (HBCUs) and tribal colleges and universities (TCUs) as guides and adopt systems to increase support for people from minoritized racial and ethnic groups; they should also seek sustainable partnerships with minority serving institutions.  Federal funding agencies, private philanthropies, and other grant-making organizations should provide increased opportunities for grants, awards, and other forms of support to increase understanding of how the policies, programs, and practices of HBCUs and TCUs support students and faculty.

The study – undertaken by the Committee on Advancing Antiracism, Diversity, Equity, and Inclusion in STEMM Organizations – was sponsored by the Alfred P. Sloan Foundation, Fred Kavli Endowment Fund, Gordon and Betty Moore Foundation, Heising-Simons Foundation, National Institutes of Health, National Science Foundation, Ralph J. Cicerone and Carol M. Cicerone Endowment for NAS Missions, Rita Allen Foundation, and the Shanahan Family Charitable Foundation.

The National Academies of Sciences, Engineering, and Medicine are private, nonprofit institutions that provide independent, objective analysis and advice to the nation to solve complex problems and inform public policy decisions related to science, technology, and medicine. They operate under an 1863 congressional charter to the National Academy of Sciences, signed by President Lincoln.

Contacts:
Megan Lowry, Media Relations Manager
Hannah Fuller, Media Relations Officer
Office of News and Public Information
202-334-2138; e-mail news@nas.edu

Instagram can be a positive force for women with mental illness, according to Concordia researcher

Fanny Gravel-Patry says that some users find relief, comfort and validation on the much-maligned app

Peer-Reviewed Publication

CONCORDIA UNIVERSITY

Fanny Gravel-Patry 

IMAGE: FANNY GRAVEL-PATRY: “I WAS INTERESTED IN WHY WOMEN ARE TURNING TO THE PLATFORM, WHAT KIND OF CONTENT THEY CONSUME AND CREATE AND WHAT THEY FIND THERE THEY CAN’T FIND ELSEWHERE.” view more 

CREDIT: CONCORDIA UNIVERSITY

The image-based social media app Instagram has come under repeated and sustained attacks over the negative mental-health effects it has on its users, in particular young women and girls, over the past few years. The extent of Instagram’s potential for harm is still being widely debated, but a Concordia researcher argues in a new paper that regular use of the app is not necessarily a bad thing. And it can in some instances be beneficial to women with mental-health issues, including eating disorders and anxiety.

In a paper published in the journal Feminist Media Studies, Concordia PhD candidate and 2021 Public Scholar Fanny Gravel-Patry conducts an in-depth study of women’s use of Instagram in their daily lives. The study follows the social media habits of three Quebec women living with mental illness who have incorporated Instagram use into their daily habits and found that it has positive effects on their mental health. She notes that they use the app in a variety of ways depending on their personalities, whether creating and finding mental-health resources, sharing their healing journeys or capturing screen shots of inspirational posts. Gravel-Patry says Instagram has a soothing effect on these women that helps them cope with limited access to mental-health resources.

“I was interested in why they are turning to the platform, what kind of content they consume and create and what they find there they can’t find elsewhere,” Gravel-Patry notes.

Healing digital habits

She says there are good reasons to focus on women's digital habits. First, adopting regular habits is often the first step people living with mental illness can do to improve their mental health, whether it is taking up exercise, going to therapy, crafting, writing in a journal or spending constructive time online. Second, she was interested in seeing how the women she interviewed were able to break away from the pattern of repetitive images portraying women as hysterical or prone to insanity to create new, more positive discourses. And third, she wanted to see if social media habits can produce a healing transformation in the long run.

“I was trying to put all of this together to see how social media fits here as something that assists in recovery and not as something that hinders it,” she says. “I also wanted to consider it not as the best tool necessarily, but because it is a tool that is available to them.”

All three women Gravel-Patry focuses on for her study are Quebec graduate students. One suffers from an eating disorder, another is dealing with generalized anxiety and an eating disorder and the third lives with anxiety, body image issues and traumas related to her childhood experiences of racism.

All of them use Instagram regularly as a way of coping with their mental illness but in different ways. One decided to share her recovery process through her account, while the other two preferred a more anonymous approach, such as taking screenshots of positive memes or following accounts with content that allays feelings of anxiety.

Mental health meets platform capitalism

She notes that Instagram is not inherently beneficial. As a company operating in the platform-capitalism paradigm, it bears its share of responsibility for contributing to an economic system that profits off women and girls who can be negatively impacted by it. This takes on added relevance at a time when mental health–care funding is targeted to self-care initiatives such as developing digital mental-health tools.

“Because there are limited resources, people do not have the choice but to take care of their own mental health and go on apps like Instagram,” she says. “But these are apps that ultimately encourage the structure of individualized commodification.”

Read the cited paper: “A series of little high fives”: mental health and digital habituation in women’s Instagram practices.”

New report exposes steep declines in data science skills among fourth- and eighth-graders nationwide

Reports and Proceedings

UNIVERSITY OF CHICAGO

CHICAGO – A new report from the Data Science 4 Everyone coalition reveals that data literacy skills among fourth and eighth-grade students have declined significantly over the last decade even as these skills have become increasingly essential in our modern, data-driven society.

Based on data from the latest National Assessment of Educational Progress results, the report uncovered several trends that raise concerns about whether the nation’s educational system is sufficiently preparing young people for a world reshaped by the rise of big data and artificial intelligence.

Key findings include:

  • The pandemic decline is part of a much longer-term trend. Between 2019 and 2022, scores in the data analysis, statistics, and probability section of the NAEP math exam fell by 10 points for eighth-graders and by four points for fourth-graders. Declining scores are part of a longer-term trend, with scores down 17 points for eighth-graders and down 10 points for fourth-graders over the last decade. That means today’s eighth-graders have the data literacy of sixth-graders from a decade ago, and today’s fourth-graders have the data literacy of third-graders from a decade ago. 
  • There are large racial gaps in scores. These gaps exist across all grade levels but are at times most dramatic in the middle and high school levels. For instance, fourth-grade Black students scored 28 points lower – the equivalent of nearly three grade levels – than their white peers in data analysis, statistics, and probability. 
  • Data-related instruction is in decline. Every state except Alabama reported a decline or stagnant trend in data-related instruction, with some states – like Maryland and Iowa – seeing double-digit drops. The national share of fourth-grade math teachers reporting “moderate” or “heavy” emphasis on data analysis dropped five percentage points between 2019 and 2022. 

“The ability to interpret, understand, and work with data is central to so many aspects of our lives and careers today. Data literacy is a must-have for every employee, every business owner, and every participant in our democracy,” said Zarek Drozda, the director of Data Science 4 Everyone, and author of the report. “Schools that prioritize teaching these skills are setting their students up for success in the modern economy, opening doors to a wider variety of options post-graduation, and building confidence for students to pursue these disciplines in higher education, including in STEM.”

Beyond STEM, the report recommends that schools build data literacy connections within subjects across the curriculum, such as social studies or English. “Digital Humanities” is an emerging field that uses data to reveal new insights into literature and history, for example. Data Science 4 Everyone is similarly encouraging cross-disciplinary collaboration via their lesson plan challenge, which provides cash prizes to teachers working together to teach data science principles.

To download a copy of the full report, visit Data Science 4 Everyone’s website, or https://tinyurl.com/3ud9mfay.


About Data Science 4 Everyone

Data Science 4 Everyone (DS4E) is a coalition and national initiative advancing data science education so that every K-12 student is equipped with the data literacy skills needed to succeed in our modern world. Equitable access to data science education is an opportunity to open doors to higher education, high-paying careers, and an engaged community. DS4E is based at the University of Chicago.

Hospitality and real estate sectors have highest rates of common mental health problems, study finds

Peer-Reviewed Publication

UNIVERSITY OF CAMBRIDGE

Mental health problems such as depression are most common in the hospitality and real estate sectors, but – at least prior to the COVID-19 pandemic – were on the increase across the board, according to new research.

Researchers from the University of Cambridge and University College London found significant gender disparities of common mental health problems against females in over half of the twenty industries studied, with the smallest gap being in the transport and storage industry and the highest gap being in the arts, entertainment and recreation industry.

In the UK, around one in seven people in the workplace experiences mental health problems, and women are nearly twice as likely to have mental health problems as men. More than half of all sickness absence days can be attributed to mental health conditions. It is estimated that economic losses caused by mental health problems account for about 4.1% of UK GDP, and that better mental health support in the workplace can save UK businesses up to £8 billion per year.

The researchers analysed data from almost 20,000 people aged between 16 and 65 across 20 industries. This data was collected as part of the Health Survey for England, a representative repeated cross-sectional survey of people in England, looking at changes in the health and lifestyles of people all over the country. The results are published in Frontiers in Public Health.

The team found an overall increase in the proportion of people reporting mental health problems, up from 16.0% in 2012-14 to 18.8% in 2016-2018. None of the industries studied experienced significant decreases in prevalence, but three industries – wholesale and retail trade, repair of motor vehicles and motorcycles; construction; and other service activities – saw significant increases.

Common mental health problems were most prevalent among those who were not working, with around one in three (33.7%) people reporting problems. In the hospitality sector (accommodation and food services) and real estate, just under one in four people (23.8% and 23.6, respectively) reported mental health problems.

The lowest prevalence was seen among professional, scientific and technical activities (15.0%), agriculture, forestry and fishing (9.6%) and mining and quarrying (6.2%).

Dr Shanquan Chen from the Department of Psychiatry, University of Cambridge, said: “Jobs that involve working face to face with the public, particularly where the employee has a degree of responsibility, and those that involve working irregular and long hours can all be emotionally demanding or even expose employees to violence and verbal aggression. This in turn could contribute to higher rates of mental health problems.”

“Nevertheless, we would still strongly encourage industry leaders – particularly in those sectors that fare worst, such as the hospitality and real estate sectors – to take an urgent look and try to identify and address the underlying issues.”

In the majority of industries (11 out of 20), mental health problems were more common among females than they were among males. This was highest in the arts, entertainment and recreation sector, where more than one in four women (26.0%) reported problems compared to around one in 20 (5.6%) of men. Not working also appeared to have a much bigger impact on females (45.0%) compared to males (21.7%).

From 2012-2014 to 2016-2018, gender disparities had widened in all but two sectors - human health and social work activities, and transport storage.

Previous studies have identified some risk factors that have gender-specific impacts on mental health. For example, working full-time decreases the risk of mental problems among males, but not among females; fixed-term contract only increases the risk of mental problems among females; males are more affected by changes in tasks at work, while lack of training, low motivation and weak social support are drivers of mental problems among females. However, the researchers say that the existing evidence cannot explain why there were disparities in some industries but not others.

The study was supported by the Medical Research Council and the NIHR Cambridge Biomedical Research Centre.

Reference
Chen, S & Wang, Y. Industry-specific prevalence and gender disparity of common mental health problems in the UK: A national repetitive cross-sectional study. Frontiers in Public Health; 9 Feb 2023; DOI: 10.3389/fpubh.2023.1054964

When it comes to financial uncertainty, men go out on a limb

Research finds men take more risks on spending decisions when the prospects of financial returns are unknown

Peer-Reviewed Publication

UNIVERSITY OF CALIFORNIA - SAN DIEGO

In everyday life, people have to make decisions in uncertain situations in which they have incomplete information, but how individuals behave in such instances is influenced by their gender. Men are more likely to interpret any information about an investment opportunity “optimistically” and can more easily be persuaded into making risky financial decisions, suggests new research from the Rady School of Management at the University of California San Diego.

The study, which is forthcoming in the journal Cognitive, Affective, and Behavioral Neuroscience, builds on existing research that shows women are more risk averse than men. However, “risk” in previous research is most usually defined as situations in which people know the specific probabilities involved, like a 50% chance of winning a coin flip.

“The uncertainty we encounter in everyday life rarely includes such precise odds – usually people have to make a decision with partial or incomplete information,” said Uma Karmarkar, study author and assistant professor of marketing and innovation at UC San Diego’s Rady School of Management and School of Global Policy and Strategy. “This research finds that men and women actually show very similar responses in low-information, uncertain financial decisions. However, it also shows a key difference: as information is added, men tend to interpret it favorably, which in turn convinces them to increase the amount of money they’re willing to invest.”

The more information you give men – good or bad – the more they pay compared to women

The research has implications for how men and women might make decisions in a range of professional settings, such as women’s likelihood to compete for leadership roles or their financial investing performance.

The primary findings were shown in two specific experiments conducted in person and online with almost 500 participants.

The experiments in the study were modeled after real-world investment decision-making, in which participants had to make spending choices using real money.

Participants in the in-person experiments were asked to play games involving actual cash stakes. For each game, they considered a bag filled with 100 red and blue poker chips. Participants had to choose how much they were willing to pay – up to $10 for a “ticket” to play a game where a single chip would be drawn from the bag. If a red chip was drawn, they would win $20. If a blue chip was drawn, they’d win nothing. However, players did not know how much of each color was in the bag. In each game, they were given a little bit of information about the colors of some of the chips, which left them overall uncertain. And each player had the option not to bet at all and pocket the $10.

“The information we added was intentionally kept ambiguous,” Karmarkar said. “We would give them some good information, some bad information and we kept some information missing. For example, we would tell them that the bag has at least 17 red chips and at least 20 blue chips, so that information on the rest of the chips is still clearly missing, with participants having to ‘gamble’ on the probability that a red chip would be pulled from the bag.”

The results revealed that when there is little information overall, both men and women are wary about spending, but the more information you give men – good or bad – the more they pay compared to women. As the total amount of information increases, the gap in behavior continues to widen.

“Missing information clearly bothers women more than men in this experiment,” Karmarkar said. “As such, this research implies that men can be more easily persuaded to spend, but this is significantly related to the availability of relevant information about the situation.”

The in-person experiment was conducted on the UC San Diego campus and included over 200 participants, mostly students, with about 58% women and about 42% men whose average age was 20. The results were replicated online with 274 participants. These individuals ranged in age from 19 to 77 (with an average age of 42), and they did not play the games with real money. The online participants consisted of about 48% women and 52% men. The replication included basic controls for factors like education, age and income and still found significant differences in decisions between genders.

For a copy of the full study, “Gender Differences in ‘Optimistic’ Information Processing in Uncertain Decisions,” please email Christine Clark at ceclark@ucsd.edu. 

Smart contact lens with navigation function, made with 3D printer!

Micro-pattern printing even on curved non-conductors without applying voltage

Peer-Reviewed Publication

NATIONAL RESEARCH COUNCIL OF SCIENCE & TECHNOLOGY

[Figure1] Meniscus phenomenon 

IMAGE: IMAGE SHOWING MENISCUS PHENOMENON view more 

CREDIT: KOREA ELECTROTECHNOLOGY RESEARCH INSTITUTE

Dr. Seol Seung-Kwon's Smart 3D Printing Research Team at KERI and Professor Lim-Doo Jeong's team at Ulsan National Institute of Science and Technology (UNIST) developed core technology for smart contact lenses that can implement augmented reality (AR)-based navigation, with a 3D printing process.

A smart contact lens is a product attached to the human eye like a normal lens and provides various information. Research on the lens is being conducted mainly on diagnosing and treating health. Recently, Google and others are developing smart contact lenses for displays that can implement AR. Still, many obstacles to commercialization exist due to severe technical challenges.

In implementing AR with smart contact lenses, electrochromic1) displays that can be driven with low power are suitable, and "Pure Prussian Blue" color, with high price competitiveness and quick contrast and transition between colors, is attracting attention as the lens’ material. However, in the past, the color was coated on the substrate in the form of a film using the electric plating method2), which limited the production of advanced displays that can express various information (letters, numbers, images)."

The achievement of KERI-UNIST lies in the fact that it is a technology that can realize AR by printing micro-patterns on a lens display using a 3D printer without applying voltage. The key is the Meniscus of used ink. The Meniscus is a phenomenon in which a curved surface is formed on the outer wall without water droplets bursting due to capillary action when water droplets are gently pressed or pulled with a certain pressure.

Prussian blue is crystallized through solvent evaporation in the Meniscus formed between the micronozzle and the substrate. The meniscus of the acidic-ferric-ferricyanide ink is formed on the substrate when the ink-filled micronozzle and substrate come in contact. Heterogeneous crystallization of FeFe(CN)6 occurs on the substrate within the meniscus via spontaneous reactions of the precursor ions (Fe3+ and Fe(CN)3−) at room temperature. Simultaneously, the solvent evaporation is occurred at the meniscus surface. When water evaporates from the meniscus, the water molecules and precursor ions move toward the meniscus surface by convective flow, generating a preferential accumulation of the precursor ions in the outer part of the meniscus. This phenomenon induces the edge-enhanced crystallization of FeFe(CN)6; this is crucial for controlling the factors that influence the crystallization of FeFe(CN)6 in the printing step to obtain uniformly printed PB patterns on a substrate. As with conventional electroplating, the substrate used to have to be a conductor when voltage was applied, but a great advantage of using the meniscus phenomenon is that there is no restriction on the substrate that can be used because crystallization occurs by natural evaporation of the solvent.

Through the precise movement of the nozzle, the crystallization of Prussian blue is continuously performed, thereby forming micro-patterns. Patterns can be formed not only on flat surfaces but also on curved surfaces. The research team's micro-pattern technology is very fine (7.2 micrometers) that can be applied to smart contact lens displays for AR, and the color is continuous and uniform.

The main expected application area is navigation. Simply by wearing a lens, navigation unfolds in front of a person's eyes through AR. Games such as the popular 'Pokemon Go' can also be enjoyed with smart contact lenses, not smartphones.

Dr. Seol Seung-Kwon's of KERI said, "Our achievement is a development of 3D printing technology that can print functional micro-patterns on non-planner substrate that can commercialize advanced smart contact lenses to implement AR." He added, "It will greatly contribute to the miniaturization and versatility of AR devices."

The related research results were recently published as a cover articler in Advanced Science (IF 17.521/JCR 4.71%), a world-renowned academic journal in the field of materials science, in recognition of its excellence.

The research team believes that this achievement will attract a lot of attention from companies related to batteries and biosensors that require micro-patterning of Prussian blue as well as the AR field, and plans to find related demand companies and promote technology transfer.

Meanwhile, KERI is a government-funded research institute under the Ministry of Science and ICT's National Research Council for Science and Technology. Dr. Seol Seung-Kwon is also a professor at the KERI campus of the University of Science and Technology (UST). <KERI>

1) Electrochromism: a phenomenon where the color of a substance changes reversibly due to an electrochemical reaction.

2) Plating is the process of applying a thin layer of another metal to improve the surface condition of an object. In this process, if electrical energy is used, it is called 'electroplating,' and if chemical reactions are utilized without electricity, it is referred to as 'electroless plating.' Particularly electroplating is mainly used in the production of jewelry such as rings.

Image presents a schematic of the PB-based EC display with a navigation function in an AR smart contact lens that shows directions to the destination to a user on the EC display by receiving GPS coordinates in real time.


Cocaine addiction makes the brain age faster, suggests study

Scientists find differences in DNA methylation inside brain region important for inhibitory control in people with cocaine use disorder

Peer-Reviewed Publication

FRONTIERS

Scientists tend to view substance addiction as primarily a disease of the brain. When we enjoy sex, food, music, or hobbies, regions of our brain within the reward pathway are flooded with pleasure-inducing dopamine. Drugs like cocaine copy this effect, except up to ten times more strongly. Healthy brains aren’t at the mercy of such dopamine rushes, however: there, the prefrontal cortex weighs options and can decide to forego pleasurable activities when it’s not the time or place. In contrast, such ‘inhibitory control’ is impaired in the addicted brain, making it hard to resist. But what are the biochemical changes in the prefrontal cortex that cause this impairment?

Now, scientists from Germany and Canada have shown in Frontiers in Psychiatry that in humans, cocaine use disorder (CUD) leads to changes in the ‘methylome’ of a subregion within the prefrontal cortex, Brodmann Area 9, thought to be important for self-awareness and inhibitory control. Typically, a greater degree of DNA methylation leads to the ‘dialing down’ of nearby genes.

“As DNA methylation is an important regulatory mechanism for gene expression, the identified DNA methylation alterations might contribute to functional changes in the human brain and thereby to the associated behavioral aspects of addiction,” said first author Eric Poisel, a PhD student at the Central Institute of Mental Health in Mannheim, Germany.

Because the study of the brain methylome is invasive, the study was done on the cryo-preserved brains of 42 deceased male donors, of whom half had had CUD while the other half had not. This is important, because most earlier studies in this field were done on the brains of rats.

Brain cells may age faster in people addicted to cocaine

The researchers found evidence that cells in Brodmann Area 9 appear biologically ‘older’ in people with CUD, evidence that these cells age faster than in people without substance use disorders. Here, they used patterns of DNA methylation as a measure of the biological age of cells in Brodmann Area 9. The biological age of cells, tissues, and organs can be greater or less than their chronological age, depending on diet, lifestyle, and exposure to disease or harmful environmental factors. Scientists can thus estimate the biological age from methylome data with established mathematical algorithms.

“We detected a trend towards stronger biological aging of the brain in individuals with cocaine use disorder compared to individuals without cocaine use disorder. This could be caused by cocaine-related disease processes in the brain, such as inflammation or cell death,” said lead author Dr Stephanie Witt, a researcher at the same institute.

“As biological age estimation is a very recent concept in addiction research and is influenced by many factors, further studies are required to investigate this phenomenon, with larger sample sizes than were possible here.”

Associations between CUD and methylated genes

Poisel and colleagues also looked at differences in the degree of methylation at 654,448 sites in the human genome, and looked for associations with the presence or absence of CUD in the life of each donor. They corrected for differences in the donor’s age, the time since death, the brain pH, and further diseases such as depressive disorder and alcohol use disorder.

They found 17 genomic regions that were more methylated in donors with CUD than in donors without CUD, and three regions that were less methylated in donors with CUD than in donors without CUD.

“We were surprised that in our network analysis changes in DNA methylation were especially prominent among genes that regulate the activity of neurons and the connectivity between them. Interestingly, differential DNA methylation was related to several transcription factors and proteins with DNA binding domains, which implies direct effects of these DNA methylation changes on gene expression. This needs to be followed up in further studies,” said Poisel.

“Also, it was fascinating that among those genes that showed the strongest changes in DNA methylation levels in our study, two genes were previously reported to regulate behavioral aspects of cocaine intake in rodent experiments,” said Witt.